Planar chiral boric acid compound based on cycloarane skeleton as well as synthesis method and application of planar chiral boric acid compound

By designing and synthesizing planar chiral boric acid compounds based on cycloaryl skeletons, the problem of limited types of chiral boric acid catalysts in the prior art has been solved, achieving efficient synthesis and high activity for application in diol desymmetry reactions.

CN122103173APending Publication Date: 2026-05-29DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
0 Cites 0 Cited by

Patent Information

Application Number
CN202411709797.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-27
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

There are few types of chiral boric acid catalysts in the current technology, and it is impossible to synthesize a series of chiral boric acids through a universal method. In addition, traditional transition metal catalysts have problems such as high cost, harsh reaction conditions and heavy metal toxicity.

Method used

A series of planar chiral borate compounds based on cycloaryl skeletons were designed. Various chiral cycloaryl skeleton borate compounds were prepared by multiple synthetic methods such as substitution reaction and lithiation boronization reaction, and applied to the desymmetry reaction of diols.

Benefits of technology

A novel chiral cycloaryl skeletal borate compound was synthesized with high yield, exhibiting excellent catalytic activity and enantioselectivity control, and is suitable for the desymmetry reaction of diols.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention provides a planar chiral boric acid compound based on a cycloarane skeleton as well as a synthesis method and application thereof. The planar chiral compound has a structure as shown in a formula I; in the formula I, R1 is selected from one of alkyl groups of C1 to C8, alkoxy groups of C1 to C8 and aryloxy groups of C1 to C20. R2 is selected from one of hydrogen, fluorine, methyl, ethyl, methoxyl, ester group, nitryl, phenyl, benzyl, tert-butyl and isopropyl. According to the invention, the planar chiral boric acid catalyst based on the cycloarane skeleton can be effectively synthesized, and the planar chiral boric acid catalyst based on the cycloarane skeleton can realize the desymmetry reaction of diol.
Need to check novelty before this filing date? Find Prior Art