High-activity pharmacokinetics experiment pollution prevention operation equipment

Abstract

The application relates to the technical field of pharmacokinetic experiment equipment, in particular to a high-activity pharmacokinetic experiment anti-pollution operation equipment, which comprises a negative pressure dosing chamber, a main pipe, a branch pipe, an air suction machine, an air purification device shell and a water storage tank. The main pipe is divided into a No. 1 pipe and a No. 2 pipe, the No. 1 pipe and the No. 2 pipe are connected through a hollow box, the inside and the end of the No. 1 pipe are provided with an anti-backflow structure, the anti-backflow structure is linked with a backflow reminding structure, and a cleaning structure is arranged in the inside of the No. 1 pipe. When the air suction machine fails, stops or abnormally generates negative pressure to cause airflow backflow, the baffle can quickly block the pipe opening, the double blocking is formed by cooperating with the conical block and the flow blocking groove, the contaminated gas containing drugs can be completely blocked from backflowing to the negative pressure dosing chamber, the cross contamination of high-activity drugs is avoided from the root, and the pharmacokinetic experiment data is ensured to be accurate and reliable.

Description

Technical Field

[0001] This invention relates to the field of pharmacokinetic experimental equipment technology, and in particular to a contamination-proof operating device for high-activity pharmacokinetic experiments. Background Technology

[0002] This invention relates to a specialized negative pressure drug delivery system adapted for pharmacokinetic experiments of highly active drugs, such as the "Negative Pressure Drug Delivery Chamber for Pharmacokinetic and Bioequivalence Studies of Inhaled Formulations" disclosed in patent number CN214232337U. This chamber includes a negative pressure drug delivery chamber, an inhalation pre-purification device, an inhaler, an air purification device, a water tank, a water pump, and hoses. Through directional negative pressure circulation, multi-stage filtration, and water mist dissolution, highly active drug residues are efficiently removed, ensuring no cross-contamination in highly active pharmacokinetic experiments. Specifically, the inhaler draws in drug-containing residual air from the chamber, filters out drug dust using the pre-purification device, and then sends it to the air purification device; the water pump drives water mist to dissolve fine drug particles, the drug-containing liquid is filtered and recycled, and the purified air returns to the chamber, forming a unidirectional airflow and preventing cross-contamination of drugs.

[0003] The main pipe in the aforementioned patent only allows for normal gas flow and does not have any anti-backflow structure. When the core equipment such as the inhaler suddenly malfunctions, stops, or experiences negative pressure abnormalities, the airflow in the pipeline is very likely to reverse and backflow, causing the drug-containing contaminated gas that has been drawn in to flow directly back into the negative pressure drug delivery chamber, resulting in cross-contamination of highly active drugs and affecting the accuracy of pharmacokinetic experimental data.

[0004] In addition, during the delivery of highly active drugs, particulate impurities such as drug dust can easily adhere to the inner wall of the main pipe and form deposits. Over time, these deposited impurities will not only cause the inner diameter of the pipe to narrow, the airflow channel to be blocked, and the resistance to increase, but will also contaminate subsequent batches of experimental samples, leading to data deviations and affecting the stability and continuity of equipment operation. Summary of the Invention

[0005] The purpose of this invention is to address the shortcomings of the prior art by proposing a pollution-proof operating device for highly active pharmacokinetic experiments.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a high-activity pharmacokinetic experimental anti-contamination operating device, comprising: a negative pressure drug administration chamber, a main pipe, branch pipes, an inhaler, an air purification device housing, and a water storage tank. The main pipe is divided into a No. 1 pipe and a No. 2 pipe, which are connected by a hollow box. The No. 1 pipe has an anti-backflow structure at its interior and end, and the anti-backflow structure is linked to a backflow reminder structure. A cleaning structure is also provided inside the No. 1 pipe, distributed inside the No. 1 pipe and the hollow box. The anti-backflow structure includes a torsion spring hinge and a baffle installed at the port of the No. 1 pipe. The upper plate of the torsion spring hinge is fixedly connected to the baffle, and the baffle seals the port of the No. 1 pipe. The No. 1 pipe is divided into a gas flow channel and a hollow channel. A conical block is fixed inside the gas flow channel. The conical block has a wide opening and a narrow opening, and a flow-blocking groove is formed between the conical block and the inner wall of the No. 1 pipe.

[0007] As a further embodiment of the present invention, the backflow warning structure includes a display tube, which is a bent design. The lower end of the display tube is located in the flow-blocking groove. A fine grid is fixed inside the display tube. An adhesive layer is provided on the inner wall of the display tube, and the adhesive layer is located above the fine grid. The display tube is transparent.

[0008] As a further embodiment of the present invention, the cleaning structure includes a conical cylinder fixed inside a gas flow channel, the conical cylinder having a spiral groove inside, a conductive block fixed to the outer wall of the gas flow channel, a horizontal plate slidably connected inside a hollow channel, the horizontal plate having a through hole, a vibration spring fixed to the inner wall of the hollow channel, one end of the vibration spring being fixed to the outer wall of the gas flow channel and passing through the through hole, an impact block fixed to the horizontal plate, and the conical cylinder also having a wide opening and a narrow opening.

[0009] As a further embodiment of the present invention, the cleaning structure also includes an iron plate, one end of which is located inside the hollow box and fixed to the iron plate.

[0010] As a further embodiment of the invention, the cleaning structure also includes a sliding groove at the bottom of the hollow box cavity, along which a rod-shaped magnet is slidably connected and fitted with a telescopic spring. The magnet is externally coated with a metal layer to enhance its hardness and prevent breakage.

[0011] As a further embodiment of the present invention, the hollow box is further provided with a collection structure inside. The collection structure includes a baffle fixed inside the hollow box, the baffle being provided with air holes, and a collection box being provided at the bottom of the hollow box and below the baffle. The side wall of the hollow box is provided with a slot for taking out and putting in the collection box, and a sealing ring is provided at the connection between the slot and the collection box to prevent gas passing through the hollow box from flowing out.

[0012] As a further embodiment of the present invention, the hollow box is provided with a cleaning component for the baffle. The cleaning component includes a threaded rod rotatably connected inside the hollow box, a vertical groove is provided on the side wall of the hollow box, and a scraper is slidably connected inside the hollow box along the vertical groove. The threaded rod passes through the scraper and is rotatably connected to the scraper.

[0013] As a further embodiment of the present invention, a motor is installed on the top of the hollow box, and the output end of the motor is fixedly connected to the top end of the threaded rod.

[0014] As a further embodiment of the present invention, the scraper is integrally provided with a wedge-shaped block, which presses against the magnet when it descends.

[0015] As a further embodiment of the present invention, the cleaning assembly further includes a solid area on the baffle, the scraper is provided with a circular groove, a return spring and a top block are installed inside the circular groove, and one end of the return spring is fixedly connected to the top block.

[0016] The present invention provides a contamination-proof operating device for high-activity pharmacokinetic experiments, the advantages of which are: 1. The present invention has an anti-backflow structure at the end and inside of the main pipe No. 1. When the inhaler malfunctions, stops, or the negative pressure is abnormal and causes backflow of airflow, the baffle can quickly block the pipe opening. Together with the conical block and the flow-blocking groove, it forms a double interception, which can completely block the backflow of drug-containing contaminated gas into the negative pressure drug delivery chamber, avoid cross-contamination of highly active drugs from the source, and ensure the accuracy and reliability of pharmacokinetic experimental data.

[0017] 2. The present invention is equipped with a cleaning structure inside the main tube and the hollow box. It can reduce the adhesion of drug dust through swirling airflow and remove the drug dust deposited on the tube wall by means of vibration and impact. Combined with the collection structure and cleaning components, it can realize the centralized collection of drug dust and the clearing of baffles and air holes, avoiding pipe blockage, airflow obstruction and sample contamination, and significantly improving the stability of equipment operation and experimental continuity. Attached Figure Description

[0018] Figure 1 This is an external view of the negative pressure drug delivery device proposed in this invention; Figure 2 This is a schematic diagram of the appearance of the main tube and the hollow box proposed in this invention; Figure 3 This is a schematic diagram of the interior of the hollow box proposed in this invention; Figure 4 This is a schematic diagram of the interior of the hollow box proposed in this invention; Figure 5 The present invention proposes Figure 4 Schematic diagram of a partial structure; Figure 6 This is a schematic diagram of the scraper proposed in this invention; Figure 7 The present invention proposes Figure 6 Enlarged view of point A; Figure 8 This is a schematic diagram of the main pipe end proposed in this invention; Figure 9 This is a cross-sectional view of the main tube proposed in this invention; Figure 10 This is a schematic diagram showing the internal structure of the hollow groove in a cross-section of the main pipe proposed in this invention. Figure 11 The present invention proposes Figure 10 Top view; Figure 12 This is a schematic diagram showing the conical block and conical cylinder exposed in a cross-sectional view of the main tube proposed in this invention; Figure 13 This is a cross-sectional view of the display tube proposed in this invention.

[0019] The components include: 1. Negative pressure drug delivery chamber; 2. Main pipe; 3. Branch pipe; 4. Inhaler; 5. Air purification device housing; 6. Water tank; 7. Pipe No. 1; 8. Pipe No. 2; 9. Hollow box; 10. Torsion spring hinge; 11. Baffle; 12. Conical block; 13. Wide opening; 15. Narrow opening; 16. Flow channel; 17. Gas flow channel; 18. Display tube; 19. Fine grid; 20. Adhesive layer; 21. Conical cylinder; 22. Spiral groove; 23. 24. Conducting block; 25. Hollow groove; 26. Through hole; 27. Vibration spring; 28. Impact block; 29. ​​Iron plate; 20. Slide groove; 31. Telescopic spring; 32. Magnet; 33. Baffle; 34. Air hole; 35. Collection box; 36. Groove opening; 37. Threaded rod; 38. Vertical groove; 39. Scraper; 40. Motor; 41. Wedge block; 42. Solid area; 43. Circular groove; 44. Return spring; 45. Top block; 46. Horizontal plate. Detailed Implementation

[0020] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance. In the description of this invention, it should be noted that unless otherwise explicitly specified and limited, the terms "installed," "connected," "linked," and "set up" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal communication of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances. The following describes embodiments of the invention based on its overall structure.

[0022] The present invention proposes a pollution-proof operating device for a high-activity pharmacokinetic experiment, comprising: a negative pressure administration chamber 1, a main pipe 2, a branch pipe 3, an inhaler 4, an air purification device housing 5, and a water storage tank 6. This part has been disclosed in patent CN214232337U and will not be described again here.

[0023] The innovative features of this invention are as follows: the main pipe 2 is divided into a first pipe 7 and a second pipe 8, which are connected by a hollow box 9. The inside and end of the first pipe 7 are provided with an anti-backflow structure, and the anti-backflow structure is linked to a backflow reminder structure. Furthermore, a cleaning structure is provided inside the first pipe 7, and the cleaning structure is distributed inside the first pipe 7 and the hollow box 9.

[0024] Specifically, the anti-backflow structure includes a torsion spring hinge 10 and a baffle 11 installed at the port of the first pipe 7. The upper plate of the torsion spring hinge 10 is fixedly connected to the baffle 11, and the baffle 11 blocks the port of the first pipe 7. The first pipe 7 is divided into a gas flow channel 17 and a hollow channel 24. A conical block 12 is fixed inside the gas flow channel 17. The conical block 12 is provided with a wide opening 13 and a narrow opening 15. A flow-blocking groove 16 is formed between the conical block 12 and the inner wall of the first pipe 7.

[0025] The working principle of the above-mentioned anti-backflow structure is as follows: when not in operation, the baffle 11 is closed. When the suction machine 4 is working, it generates suction, and then the baffle 11 rotates to open the first pipe 7 so that the equipment can work normally.

[0026] When gas flows backward, under the combined action of the resetting action of the torsion spring hinge 10 and the thrust of the backward-flowing gas, the baffle 11 will quickly return to its original position and tightly seal the port of tube 7, effectively blocking the backflow of drug-containing contaminated gas into the negative pressure drug delivery chamber 1, and avoiding cross-contamination of the experiment caused by the residue of highly active drugs.

[0027] The conical block 12 is fixed in the gas flow channel 17 with the wide opening 13 facing the baffle 11 and the narrow opening 15 facing the hollow box 9. The tapered structure of the wide opening 13 and the narrow opening 15 allows the airflow to enter from the wide opening 13 and exit smoothly through the narrow opening 15 when the airflow is flowing normally. This design can gradually contract the airflow and improve the airflow velocity and directionality when the airflow passes through, ensuring that the suction machine 4 can draw air smoothly and efficiently. It can also form a significant cross-sectional sudden contraction resistance when the backflow occurs.

[0028] The main manifestation is that the countercurrent gas rushes back from the narrow opening 15 towards the conical block 12, and is intercepted by the flow-blocking groove 16 formed by the conical block 12 and the inner wall of the first pipe 7. At the same time, a vortex buffer is formed between the outer wall of the cone and the inner wall of the pipe. Combined with the tapered structure, the countercurrent airflow is continuously compressed and the resistance is superimposed, which greatly weakens the countercurrent power and completely blocks the pollution caused by the backflow of polluting gas from the airflow channel morphology.

[0029] Furthermore, the backflow warning structure includes a display tube 18, which has a bent design. The lower end of the display tube 18 is located in the flow-blocking groove 16. A fine mesh 19 is fixed inside the display tube 18. An adhesive layer 20 is provided on the inner wall of the display tube 18, and the adhesive layer 20 is located above the fine mesh 19. The display tube 18 has a transparent design.

[0030] The working principle of the above-mentioned backflow warning structure is as follows: Red powder is placed above the fine grid 19. When the gas flows back, the backflowing gas comes into the baffle groove 16, then enters from the bottom of the display tube 18 and flows upward, impacting the red powder above the fine grid 19. The red powder is then blown up and adheres to the adhesive layer 20. When red powder is seen adhering to the wall of the display tube 18 from bottom to top, it indicates that backflow is occurring and the equipment needs to be inspected, thus serving as a reminder.

[0031] Specifically, the cleaning structure includes a conical cylinder 21 fixed inside the gas flow channel 17. The conical cylinder 21 has a spiral groove 22 inside and also has a wide opening and a narrow opening.

[0032] In addition, a conductive block 23 is fixed to the outer wall of the gas flow channel 17, and a horizontal plate 45 is slidably connected inside the hollow channel 24. The horizontal plate 45 is provided with a through hole 25. A vibration spring 26 is fixed to the inner wall of the hollow channel 24. One end of the vibration spring 26 is fixed to the outer wall of the gas flow channel 17, and the vibration spring 26 passes through the through hole 25. An impact block 27 is fixed to the horizontal plate 45. One end of the horizontal plate 45 is located inside the hollow box 9 and is fixed to the iron plate 28.

[0033] Furthermore, the cleaning structure also includes a groove 29 at the bottom of the hollow box 9's inner cavity. A rod-shaped magnet 31 is slidably connected to the bottom of the hollow box 9's inner cavity along the groove 29 and is equipped with a telescopic spring 30. The magnet 31 is covered with a metal coating to enhance its hardness and prevent breakage. The scraper 38 is integrally equipped with a wedge-shaped block 40, which presses against the magnet 31 when it descends.

[0034] The working principle of the above-mentioned cleaning structure is as follows: When the equipment is working, the gas flows from the wide opening of the conical cylinder 21 to the narrow opening. With the help of the spiral groove 22, the airflow is guided to form a spiral swirling state. The tapered structure of the conical cylinder 21 can increase the airflow velocity, and the spiral groove 22 can enhance the airflow disturbance and propulsion force, allowing the drug-containing residual gas to pass through the gas flow channel 17 faster and more smoothly. This effectively avoids drug dust adhering and accumulating on the pipe wall, while improving the suction efficiency and gas delivery stability of the inhaler 4.

[0035] When the scraper 38 descends, it presses the magnet 31 through the wedge block 40. Then the magnet 31 moves along the slide 29 toward the iron plate 28 and compresses the telescopic spring 30. The function of the telescopic spring 30 is to reset the iron plate 28. After the magnet 31 moves, the distance between it and the iron plate 28 is close. Then the magnet 31 can attract the iron plate 28 (it cannot attract at a distance). After that, the impact block 27 on the horizontal plate 45 separates from the conduction block 23, and the horizontal plate 45 moves to bend the vibration spring 26.

[0036] When scraper 38 rises to the initial position ( Figure 5 The restoring force of the telescopic spring 30 is greater than the magnetic attraction force, and then the magnet 31 separates from the iron plate 28. After that, the bent vibration spring 26 returns to its original position and moves the horizontal plate 45 and the impact block 27 back to their original position. Then the impact block 27 impacts the conduction block 23, and the impact vibration is transmitted to the main pipe 2, which facilitates the falling of the drug dust on the inner wall of the gas flow channel 17, preventing adhesion and achieving the purpose of cleaning. At the same time, the rebound vibration of the telescopic spring 30 further causes the drug dust to fall. After that, the falling drug dust flows along the gas flow into the interior of the hollow box 9, and then this part of the drug dust is collected by the collection structure inside the hollow box 9.

[0037] Next, a collection structure is also provided inside the hollow box 9. The collection structure includes a baffle 32 fixed inside the hollow box 9, the baffle 32 is provided with air holes 33, and a collection box 34 is provided at the bottom of the hollow box 9 and below the baffle 32. A slot 35 is provided on the side wall of the hollow box 9 for taking out and putting in the collection box 34. A sealing ring is provided at the connection between the slot 35 and the collection box 34 to prevent the gas passing through the hollow box 9 from flowing out. The collection box 34 is taken out from the slot 35 to pour out the collected medicine dust and other impurities.

[0038] The working principle of the above collection structure is as follows: the drug dust (particulate) cleaned from the inner wall of the gas flow channel 17 comes into the interior of the hollow box 9. At this time, the gas can flow normally through the air hole 33 on the baffle 32, but the drug dust in the gas is blocked by the baffle 32. Some of the drug dust falls directly into the interior of the collection box 34, and the other part will remain on the surface of the baffle 32. At this time, the baffle 32 is processed by the cleaning component.

[0039] As an example, the hollow box 9 is provided with a cleaning assembly for the baffle 32. The cleaning assembly includes a threaded rod 36 rotatably connected inside the hollow box 9, a vertical groove 37 provided on the side wall of the hollow box 9, a scraper 38 slidably connected inside the hollow box 9 along the vertical groove 37, the threaded rod 36 passing through the scraper 38 and rotatably connected to the scraper 38, and a motor 39 is installed on the top of the hollow box 9. The output end of the motor 39 is fixedly connected to the top end of the threaded rod 36.

[0040] Meanwhile, the cleaning assembly also includes a solid area 41 on the baffle 32, and a circular groove 42 is provided on the scraper 38. A reset spring 43 and a top block 44 are installed inside the circular groove 42, and one end of the reset spring 43 is fixedly connected to the top block 44.

[0041] The working principle of the above-mentioned cleaning components is as follows: the motor 39 starts and drives the threaded rod 36 to rotate in both directions. Then the scraper 38 moves up and down along the vertical groove 37. When the scraper 38 descends, the wedge block 40 on the scraper 38 presses the magnet 31 to move it toward the iron plate 28. When the scraper 38 descends, the medicine dust on the surface of the baffle 32 will be scraped off and fall into the collection box 34, thereby achieving the cleaning of the baffle 32 and further collection of medicine dust.

[0042] In the initial state, the top block 44 (made of a weakly elastic material, including but not limited to rubber) is held in place by the solid area of ​​the baffle 32, so the top block 44 is completely retracted inside the circular groove 42. When the scraper 38 moves the top block 44 to the air hole 33, the compressed return spring 43 pops the top block 44 out, and then the top block 44 rushes towards the air hole 33, pushing out the impurities inside and falling into the collection box 34. This helps to clear the air hole 33, prevent blockage, and ensure that the baffle 32 works stably for a long time.

[0043] Because the top block 44 has weak elasticity, it can impact the air hole 33, and can also be pulled away from the air hole 33 by means of weak elasticity.

[0044] When the scraper 38 moves to the solid area 41, it will pull the top block 44 away from the air hole 33. Then the top block 44 will be pressed back by the solid area 33, causing the top block 44 to retract into the circular groove 42 and compress the return spring 43. Repeating this operation can clear the air holes 33 at different heights.

[0045] The workflow of this invention is as follows: When the equipment is working normally, the suction machine 4 starts to generate negative pressure suction, which opens the baffle 11 at the port of the first pipe 7. The drug-containing gas in the negative pressure drug delivery chamber 1 enters the branch pipe 3 and the main pipe 2 in sequence, and flows in the forward direction along the gas flow groove 17 of the first pipe 7. The airflow increases the flow rate through the tapered block 12 gradually narrowing channel, and then forms a vortex through the tapered cylinder 21 and the spiral groove 22, reducing the adhesion of drug dust on the pipe wall. Then, it enters the air purification device housing 5 through the hollow box 9 and the second pipe 8 for treatment. The purified air is circulated back, forming a stable anti-pollution airflow. When backflow occurs, the baffle 11 quickly seals the pipe opening under the action of the torsion spring hinge 10 and the backflow thrust. Combined with the vortex buffer and resistance blocking of the cone block 12 and the flow-blocking groove 16, it doubles the prevention of backflow of polluted gas. At the same time, the backflow gas enters the display tube 18, blows up red powder and adheres to the adhesive layer 20, visually indicating the backflow abnormality and facilitating timely maintenance. When cleaning pipe 7 of main pipe 2, motor 39 drives threaded rod 36 to drive scraper 38 to move up and down along baffle 32, scraping off the dust on the surface of baffle 32 and clearing the air hole 33 through top block 44. When scraper 38 descends, wedge block 40 presses magnet 31 close to iron plate 28, pulling horizontal plate 45 and vibration spring 26 to deform. After scraper 38 returns to its original position, magnet 31 separates from iron plate 28 under the action of extension spring 30. Vibration spring 26 rebounds and drives impact block 27 to impact conduction block 23. The vibration causes the dust on the pipe wall to fall off. The fallen dust is intercepted by baffle 32 and falls into collection box 34 for centralized storage, realizing automatic cleaning and ensuring long-term stable operation of equipment.

[0046] The above are merely preferred embodiments of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A contamination-proof operating device for a high-activity pharmacokinetic experiment, comprising: The negative pressure drug delivery chamber (1), main pipe (2), branch pipe (3), inhaler (4), air purification device housing (5), and water tank (6) are characterized in that the main pipe (2) is divided into a first pipe (7) and a second pipe (8), the first pipe (7) and the second pipe (8) are connected by a hollow box (9), the first pipe (7) is provided with an anti-backflow structure at its interior and end, and the anti-backflow structure is linked to a backflow reminder structure, and a cleaning structure is provided inside the first pipe (7), the cleaning structure being distributed inside the first pipe (7) and the hollow box (9). The anti-backflow structure includes a torsion spring hinge (10) and a baffle (11) installed at the port of the first pipe (7). The upper plate of the torsion spring hinge (10) is fixedly connected to the baffle (11). The baffle (11) blocks the port of the first pipe (7). The first pipe (7) is divided into a gas flow channel (17) and a hollow channel (24). A conical block (12) is fixed inside the gas flow channel (17). The conical block (12) is provided with a wide opening (13) and a narrow opening (15). A flow-blocking groove (16) is formed between the conical block (12) and the inner wall of the first pipe (7).

2. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 1, characterized in that, The backflow warning structure includes a display tube (18), which is a bent design. The lower end of the display tube (18) is located in the flow-blocking groove (16). A fine grid (19) is fixed inside the display tube (18). An adhesive layer (20) is provided on the inner wall of the display tube (18), and the adhesive layer (20) is located above the fine grid (19). The display tube (18) is a transparent design.

3. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 1, characterized in that, The cleaning structure includes a conical cylinder (21) fixed inside a gas flow channel (17), a spiral groove (22) inside the conical cylinder (21), a conductive block (23) fixed to the outer wall of the gas flow channel (17), a horizontal plate (45) slidably connected inside the hollow channel (24), a through hole (25) provided in the horizontal plate (45), a vibration spring (26) fixed to the inner wall of the hollow channel (24), one end of the vibration spring (26) being fixed to the outer wall of the gas flow channel (17), and the vibration spring (26) penetrating through the through hole (25), and an impact block (27) fixed to the horizontal plate (45).

4. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 3, characterized in that, The cleaning structure also includes an iron plate (28), one end of which is located inside the hollow box (9) and fixed to the iron plate (28).

5. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 4, characterized in that, The cleaning structure also includes a groove (29) provided at the bottom of the inner cavity of the hollow box (9), and a rod-shaped magnet (31) is slidably connected along the groove (29) at the bottom of the inner cavity of the hollow box (9) and a telescopic spring (30) is provided.

6. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 5, characterized in that, The hollow box (9) is also provided with a collection structure inside. The collection structure includes a baffle (32) fixed inside the hollow box (9). The baffle (32) is provided with air holes (33). A collection box (34) is provided at the bottom of the hollow box (9) and below the baffle (32). A slot (35) is provided on the side wall of the hollow box (9) for taking out and putting in the collection box (34).

7. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 6, characterized in that, The hollow box (9) is provided with a cleaning component for the baffle (32). The cleaning component includes a threaded rod (36) rotatably connected inside the hollow box (9). The side wall of the hollow box (9) is provided with a vertical groove (37). A scraper (38) is slidably connected inside the hollow box (9) along the vertical groove (37). The threaded rod (36) passes through the scraper (38) and is rotatably connected to the scraper (38).

8. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 7, characterized in that, A motor (39) is installed on the top of the hollow box (9), and the output end of the motor (39) is fixedly connected to the top end of the threaded rod (36).

9. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 7, characterized in that, The scraper (38) is integrally provided with a wedge block (40), which presses against the magnet (31) when it descends.

10. The anti-contamination operating equipment for a high-activity pharmacokinetic experiment according to claim 7, characterized in that, The cleaning assembly also includes a solid area (41) on the baffle (32), and the scraper (38) is provided with a circular groove (42). A reset spring (43) and a top block (44) are installed inside the circular groove (42), and one end of the reset spring (43) is fixedly connected to the top block (44).

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