A dimethomorph- chlorothalonil inhibitory fungicidal composition
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- BENGBU GERUN BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-02-28
- Publication Date
- 2026-06-26
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Abstract
Description
Technical Field
[0001] This invention relates to the field of pesticides, specifically to a cyprodinil-chlorfluazol inhibitory and bactericidal composition. Background Technology
[0002] In agricultural production, crop diseases severely impact crop yield and quality. Currently, a wide variety of fungicides are available for controlling crop diseases; however, long-term use of a single fungicide can easily lead to drug resistance in pathogens, resulting in a gradual decline in control effectiveness. Furthermore, some fungicides have a narrow spectrum of control, making them ineffective against situations where multiple diseases occur simultaneously.
[0003] Cyprodinil or cyprodinil acetate is an organic amine fungicide. Its mechanism of action is to disrupt the cell membrane of pathogens, causing the cell contents to leak out, thereby leading to the death of the pathogens. Cyprodinil has broad-spectrum fungicidal activity, with certain control effects against diseases caused by various fungi, bacteria, and viruses. It also has systemic and translocative properties, allowing it to be absorbed by plants and translocated within them, thus providing both preventative and curative effects against plant diseases. However, long-term use of cyprodinil can lead to drug resistance in pathogens, and its control effect on certain stubborn diseases is limited.
[0004] Chlorfluazuron is a novel triazole fungicide with excellent fungicidal activity and good control effects against a variety of fungal diseases. As a novel succinate dehydrogenase inhibitor, chlorfluazuron has excellent control efficacy against ascomycete diseases such as powdery mildew and rust. However, long-term use as a single agent can lead to mutations in the SDH gene of some strains (such as Fusarium graminearum, the causal agent of wheat blight).
[0005] However, the use of cyprodinil or clofibrazole alone still has certain limitations, such as higher dosage and shorter duration of effect.
[0006] Therefore, developing a fungicide composition with synergistic effects, broad spectrum of prevention and control, long duration of effect, and the ability to delay the development of drug resistance in pathogens is of great practical significance. Summary of the Invention
[0007] In order to overcome the above-mentioned technical problems, the present invention aims to provide a fungicide composition containing cymoxanil or cymoxanil acetate and chlorfluazuron and its application, which solves the problems that existing fungicides have limited fungicide activity and that long-term single use can easily lead to the development of drug resistance in pathogens, resulting in a decline in the control effect.
[0008] The objective of this invention can be achieved through the following technical solutions:
[0009] A bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising 10-90% by weight of the active ingredient, with the remainder being excipients;
[0010] The active ingredients include a first active ingredient and a second active ingredient;
[0011] The first active ingredient is octochlor or octochlor acetate;
[0012] The second active ingredient is chlorfluazuron;
[0013] The mass ratio of the first active ingredient to the second active ingredient is (10-60):(5-30).
[0014] As a further aspect of the present invention: the mass ratio of the first effective component to the second effective component is (20-40):(10-20).
[0015] As a further aspect of the present invention, the mass ratio of the first effective component to the second effective component is 20:10.
[0016] As a further aspect of the present invention, the dosage form of the bactericidal composition includes, but is not limited to, aqueous suspension, wettable powder, microemulsion, soluble liquid, emulsifiable concentrate, water emulsion, suspension emulsion, microcapsule suspension, and water-dispersible granules.
[0017] As a further aspect of the present invention: the bactericidal composition is a wettable powder, wherein the excipients in the wettable powder include a dispersant, a wetting agent, a binder, and a filler; the dispersant is one of sodium dodecylbenzene sulfonate and sodium lignosulfonate; the wetting agent is one of a spreading powder and sodium dodecylbenzene sulfonate; the binder is starch; and the filler is one of diatomaceous earth and kaolin.
[0018] As a further aspect of the present invention: the dosage form of the composition is a suspension, and the excipients include a dispersant, a wetting agent, an antifoaming agent, a thickener, an antifreeze agent, and deionized water; the dispersant is one of naphthalene sulfonate dispersant SP-2818 and polycarboxylate dispersant SP-2836; the wetting agent is one of sodium dodecyl sulfate and sodium dodecylbenzene sulfonate; the antifoaming agent is defoaming agent DF-520; the thickener is one of xanthan gum and methylcellulose; and the antifreeze agent is glycerin.
[0019] As a further aspect of the present invention: the dosage form of the composition is a microemulsion, and the excipients in the microemulsion include a surfactant, a disintegrant, an oil phase solvent, and water; the surfactant is one of agricultural emulsion No. 600 and agricultural emulsion No. 700; the disintegrant is one of ammonium sulfate and sodium bicarbonate; and the oil phase solvent is one of xylene and ethyl acetate.
[0020] As a further aspect of the present invention: the application of the fungicidal composition containing octochlor or octochlor acetate and chlorfluazuron in the prevention and control of crop diseases.
[0021] As a further aspect of the present invention: the diseases are powdery mildew, rust, leaf spot, wilt, verticillium wilt, rot, rice blast, gray mold, root rot, and canker.
[0022] The beneficial effects of this invention are:
[0023] This invention discloses a fungicidal composition containing cyprodinil or cyprodinil acetate and chlorfluazuron, and its application. The fungicidal effect is achieved by utilizing the different mechanisms of action of cyprodinil or cyprodinil acetate and chlorfluazuron. When combined in a specific ratio, their different mechanisms of action result in a significant synergistic effect, improving the fungicidal efficacy, reducing the dosage, and decreasing pesticide residues. The composition of this invention has good systemic and penetrating properties, enabling it to maintain its efficacy within the crop for a prolonged period, extending the duration of action, and reducing the frequency of application and costs.
[0024] Cyprodinil is a broad-spectrum antibacterial agent that effectively inhibits the growth of various fungi and bacteria, showing particularly good results in treating fungal diseases. Chlorfenapyr is a novel systemic fungicide that specifically inhibits the growth of pathogens, especially showing significant inhibitory effects against certain resistant pathogens. Combining these two agents not only enhances the fungicidal effect but also effectively prevents the development of drug resistance in pathogens. The working principle is that cyprodinil interferes with the growth and metabolism of pathogens, blocking their reproduction; while chlorfenapyr, through its unique pesticide mechanism, penetrates deeper into the pathogen's body, disrupting its physiological structure. The synergistic effect of the two agents achieves a more efficient fungicidal effect. Detailed Implementation
[0025] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.
[0026] Example 1:
[0027] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0028] Weigh the following components according to the following mass ratio: 40% active ingredient, 4% dispersant, 3% wetting agent, 2% binder, and filler to make up to 100%; wherein, the mass ratio of cymoxanil and chlorfluazuron in the active ingredient is 20:10; the dispersant is sodium dodecylbenzenesulfonate; the wetting agent is a separating powder; the binder is starch; and the filler is diatomaceous earth.
[0029] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤45μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and chlorfenapyr in the form of a wettable powder.
[0030] Example 2:
[0031] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0032] Weigh the following components according to the following mass ratio: 50% active ingredient, 5% dispersant, 4% wetting agent, 3% binder, and filler to make up to 100%; wherein, the mass ratio of octenylamine and chlorfluazuron in the active ingredient is 30:15; the dispersant is sodium dodecylbenzenesulfonate; the wetting agent is a separating powder; the binder is starch; and the filler is kaolin.
[0033] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤45μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and chlorfenapyr in the form of a wettable powder.
[0034] Example 3:
[0035] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0036] The following components are weighed according to the following mass ratio: 55% active ingredient, 4% dispersant, 5% wetting agent, 1% binder, and filler to make up to 100%; wherein, the mass ratio of octochlor acetate and chlorfluazuron in the active ingredient is 40:20; the dispersant is sodium lignosulfonate; the wetting agent is sodium dodecylbenzenesulfonate; the binder is starch; and the filler is kaolin.
[0037] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤45μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and chlorfenapyr in the form of a wettable powder.
[0038] Example 4:
[0039] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0040] Weigh the following components according to the following mass ratio: 30% active ingredient, 5% dispersant, 4% wetting agent, 3% defoamer, 2% thickener, 1% antifreeze agent, and deionized water to bring the total to 100%; wherein, the mass ratio of octenylamine and chlorfluazuron in the active ingredient is 20:10; the dispersant is naphthalene sulfonate dispersant SP-2818; the wetting agent is sodium dodecyl sulfate; the defoamer is defoamer DF-520; the thickener is xanthan gum; and the antifreeze agent is glycerin.
[0041] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤60μm to obtain a bactericidal composition containing octenamide or octenamide acetate and chlorfenapyr in the form of a suspension.
[0042] Example 5:
[0043] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0044] Weigh the following components according to the following mass ratio: 40% active ingredient, 4% dispersant, 5% wetting agent, 2% defoamer, 1% thickener, 2% antifreeze agent, and deionized water to bring the total to 100%; wherein, the mass ratio of octenylamine and chlorfluazuron in the active ingredient is 30:15; the dispersant is naphthalene sulfonate dispersant SP-2818; the wetting agent is sodium dodecyl sulfate; the defoamer is defoamer DF-520; the thickener is carboxymethyl cellulose; and the antifreeze agent is glycerin.
[0045] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤60μm to obtain a bactericidal composition containing octenamide or octenamide acetate and chlorfenapyr in the form of a suspension.
[0046] Example 6:
[0047] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0048] Weigh the following components according to the following mass ratio: 20% active ingredient, 6% dispersant, 6% wetting agent, 1% defoamer, 3% thickener, 2% antifreeze agent, and deionized water to bring the total to 100%; wherein, the mass ratio of octochlor acetate and chlorfluazuron in the active ingredient is 40:20; the dispersant is polycarboxylate dispersant SP-2836; the wetting agent is sodium dodecylbenzenesulfonate; the defoamer is defoamer DF-520; the thickener is xanthan gum; and the antifreeze agent is glycerin.
[0049] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤60μm to obtain a bactericidal composition containing octenamide or octenamide acetate and chlorfenapyr in the form of a suspension.
[0050] Example 7:
[0051] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0052] Weigh the following components according to the following mass ratio: 50% active ingredient, 5% surfactant, 4% disintegrant, 3% oil phase solvent, and water to make up to 100%; wherein, the mass ratio of octochlor and chlorfluazuron in the active ingredient is 20:10; the surfactant is agricultural emulsion 600; the disintegrant is ammonium sulfate; and the oil phase solvent is xylene.
[0053] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤35μm to obtain a bactericidal composition containing octenamide or octenamide acetate and chlorfenapyr in the form of a microemulsion.
[0054] Example 8:
[0055] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0056] Weigh the following components according to the following mass ratio: 40% active ingredient, 4% surfactant, 3% disintegrant, 2% oil phase solvent, and water to make up to 100%; wherein, the mass ratio of octochlor and chlorfluazuron in the active ingredient is 30:15; the surfactant is agricultural emulsion 600; the disintegrant is ammonium sulfate; and the oil phase solvent is ethyl acetate.
[0057] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤35μm to obtain a bactericidal composition containing octenamide or octenamide acetate and chlorfenapyr in the form of a microemulsion.
[0058] Example 9:
[0059] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0060] Weigh the following components according to the following mass ratio: 30% active ingredient, 3% surfactant, 2% disintegrant, 1% oil phase solvent, and water to make up to 100%; wherein, the mass ratio of octochlor acetate and chlorfluazuron in the active ingredient is 40:20; the surfactant is agricultural emulsion 700; the disintegrant is sodium bicarbonate; and the oil phase solvent is xylene.
[0061] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤35μm to obtain a bactericidal composition containing octenamide or octenamide acetate and chlorfenapyr in the form of a microemulsion.
[0062] Comparative Example 1:
[0063] This comparative example illustrates a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0064] Weigh the following components according to the following mass ratio: 40% active ingredient, 4% dispersant, 3% wetting agent, 2% binder, and filler to make up to 100%; wherein, the active ingredient is octochlor; the dispersant is sodium dodecylbenzenesulfonate; the wetting agent is a separating agent; the binder is starch; and the filler is diatomaceous earth.
[0065] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤45μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and chlorfenapyr in the form of a wettable powder.
[0066] Comparative Example 2:
[0067] This comparative example illustrates a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0068] Weigh the following components according to the following mass ratio: 40% active ingredient, 4% dispersant, 3% wetting agent, 2% binder, and filler to make up to 100%; wherein, the active ingredient is octochlor acetate; the dispersant is sodium dodecylbenzenesulfonate; the wetting agent is a separating powder; the binder is starch; and the filler is diatomaceous earth.
[0069] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤45μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and chlorfenapyr in the form of a wettable powder.
[0070] Comparative Example 3:
[0071] This comparative example illustrates a method for preparing a bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron, comprising the following steps:
[0072] Weigh the following components according to the following mass ratio: 40% active ingredient, 4% dispersant, 3% wetting agent, 2% binder, and filler to make up to 100%; wherein, the active ingredient is chlorfluazuron; the dispersant is sodium dodecylbenzenesulfonate; the wetting agent is a separating agent; the binder is starch; and the filler is diatomaceous earth.
[0073] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤45μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and chlorfenapyr in the form of a wettable powder.
[0074] The fungicidal compositions of Examples 1-9 and Comparative Examples 1-3 were tested to assess their inhibitory effect on strawberry powdery mildew. The fungicide was sprayed at the early stage of powdery mildew in greenhouse strawberries. Before spraying, any sporadic powdery mildew-infected fruits in each experimental plot were removed. The experimental strawberry variety was Hongyan. A Delixi backpack-mounted intelligent electric sprayer (MH-D16-3) was used to carefully and comprehensively spray the upper and lower surfaces of the strawberry leaves, inflorescences, and young fruits to ensure efficacy. No other pest or disease control agents were used during the experiment. Two treatments were conducted, with the second treatment 7 days after the first. The incidence of disease on young fruits was assessed 7 and 14 days after the second treatment. The fungicidal composition was diluted 1000 times. A randomized block design was used with four replicates. The experimental plots were 20m². 2 The experiment used a uniform spraying method on the stems and leaves of the plants for pesticide application, with a spray volume of 675L per hectare. The blank control was sprayed with 675L of clean water per hectare.
[0075] The test results are shown in the table below:
[0076]
[0077]
[0078] Referring to the data in the table above, and based on the comparison between Examples 1-9 and Comparative Examples 1-3, it can be seen that the compound bactericidal composition of this application, when rationally combined with cymoxanil or cymoxanil acetate and chlorfluazuron, has excellent control effects.
[0079] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0080] The above description is merely an example and illustration of the present invention. Those skilled in the art can make various modifications or additions to the specific embodiments described or use similar methods to replace them, as long as they do not deviate from the invention or exceed the scope defined in this application, they should all fall within the protection scope of the present invention.
Claims
1. A bactericidal composition containing octenylamine or octenylamine acetate and chlorfenapyr, characterized in that, It contains 10-90% active ingredients by weight, with the remainder being excipients; The active ingredients include a first active ingredient and a second active ingredient; The first active ingredient is octochlor or octochlor acetate; The second active ingredient is chlorfluazuron; The mass ratio of the first active ingredient to the second active ingredient is (10-60):(5-30).
2. The bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron according to claim 1, characterized in that, The mass ratio of the first active ingredient to the second active ingredient is (20-40):(10-20).
3. The bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron according to claim 2, characterized in that, The mass ratio of the first active ingredient to the second active ingredient is 20:
10.
4. The bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron according to claim 1, characterized in that, The formulations of the bactericidal composition include aqueous suspensions, wettable powders, microemulsions, soluble liquids, emulsifiable concentrates, water emulsions, suspensions, microcapsule suspensions, and water-dispersible granules.
5. The bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron according to claim 4, characterized in that, The bactericidal composition is a wettable powder, and the excipients in the wettable powder include a dispersant, a wetting agent, a binder, and a filler; the dispersant is one of sodium dodecylbenzene sulfonate and sodium lignosulfonate; the wetting agent is one of a spreading powder and sodium dodecylbenzene sulfonate; the binder is starch; and the filler is one of diatomaceous earth and kaolin.
6. The bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron according to claim 4, characterized in that, The composition is in the form of a suspension, and the excipients include a dispersant, a wetting agent, an antifoaming agent, a thickener, an antifreeze agent, and deionized water; the dispersant is one of naphthalene sulfonate dispersant SP-2818 and polycarboxylate dispersant SP-2836; the wetting agent is one of sodium dodecyl sulfate and sodium dodecylbenzene sulfonate; the antifoaming agent is defoaming agent DF-520; the thickener is one of xanthan gum and methylcellulose; and the antifreeze agent is glycerin.
7. The bactericidal composition containing octochlor or octochlor acetate and chlorfluazuron according to claim 4, characterized in that, The composition is in the form of a microemulsion, and the excipients in the microemulsion include a surfactant, a disintegrant, an oil phase solvent, and water; the surfactant is one of agricultural emulsion No. 600 and agricultural emulsion No. 700; the disintegrant is one of ammonium sulfate and sodium bicarbonate; and the oil phase solvent is one of xylene and ethyl acetate.
8. The application of the fungicidal composition containing octochlor or octochlor acetate and chlorfluazuron according to claim 1 in the prevention and control of crop diseases.
9. The application according to claim 8, characterized in that, The diseases mentioned are powdery mildew, rust, leaf spot, wilt, verticillium wilt, rot, rice blast, gray mold, root rot, and canker.