A synthesis process of methylprednisolone intermediate reduction product
By optimizing the reaction conditions using haloalkane solvents and Lewis acid catalysts in the preparation process of methylprednisolone intermediates, the problems of high solvent toxicity and harsh reaction conditions in existing technologies have been solved, achieving high-yield and high-quality production of methylprednisolone intermediates suitable for industrial applications.
CN122404459APending Publication Date: 2026-07-17YUNNAN ZEWEI PHARM CO LTD
View PDF 0 Cites 0 Cited by
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- YUNNAN ZEWEI PHARM CO LTD
- Filing Date
- 2026-01-21
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing processes for preparing methylprednisolone intermediates have problems such as high solvent toxicity, harsh reaction conditions, high cost, unsuitability for industrial production, and unstable product quality.
Method used
The ketalization and reduction reactions were optimized by using haloalkanes as solvents and Lewis acid catalysts, and the reaction temperature and time were controlled to improve product quality and yield.
Benefits of technology
It has achieved high-yield, high-quality production of methylprednisolone intermediates, reduced costs, simplified operating procedures, and is suitable for industrial production.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure SMS_1 
Figure SMS_2 
Figure SMS_3
Abstract
本发明提供一种甲泼尼龙中间体还原物的合成工艺，涉及原料药中间体的合成工艺技术领域，包括以下步骤（1）缩酮反应：以甲泼尼龙中间体氧化物为原料，在卤代烷烃类溶剂中与乙二醇、原甲酸酯和酸催化剂进行反应，制得缩酮物；（2）还原反应：将缩酮物溶于四氢呋喃、甲醇溶剂中，在路易斯酸类催化剂存在下，与硼氢化物还原剂进行还原反应，经后处理得到甲泼尼龙中间体还原物；本发明通过在缩酮工序引入卤代烷烃类溶剂，在还原工序通过添加路易斯酸类催化剂，降低反应温度，缩短反应时间，并降低异构体杂质比例，该工艺收率高、产品质量好、成本低、操作简便。
Need to check novelty before this filing date? Find Prior Art