A method for detecting the content of chlorpheniramine maleate in compound amiphenazone granules
By using acetonitrile-water mixed solvent and specific HPLC conditions, the problem of inaccurate determination of chlorpheniramine maleate content in compound acetaminophen granules was solved, achieving higher detection accuracy and quality control, and simplifying the operation process.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HEBEI CHANGTIAN PHARM CO LTD
- Filing Date
- 2026-05-13
- Publication Date
- 2026-07-17
AI Technical Summary
In the existing technology, the method for determining the content of chlorpheniramine maleate in compound acetaminophen and chlorpheniramine granules has the problem of incomplete extraction, which leads to the test results being significantly lower than the actual content and cannot accurately reflect the quality of the drug.
An acetonitrile-water (3:7, v/v) mixed solvent was used instead of pure acetonitrile as the solvent for the test sample to ensure complete dissolution of sucrose and chlorpheniramine maleate. An HPLC detection method using octadecylsilane-bonded silica gel as the packing material, combined with a specific mobile phase and detection wavelength, was used to achieve accurate extraction and detection of the active ingredients.
It improves the accuracy and reliability of test results, making the measured results close to the true content, with a recovery rate of 99.1%-99.8%, simplifies the operation steps, and enhances the level of quality control.
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