Application of thalia dealbata in inhibiting PI3K / Akt / mTOR signaling pathway to slow down animal cell senescence

By inhibiting the PI3K/Akt/mTOR and S6Kl signaling pathways, the application of *Heliotropium indicum* in formulations has solved the problem of insufficient antioxidant and anti-inflammatory effects in existing technologies, achieving an effective slowing down of animal cell aging and enhancing its application in drug development.

CN122440705APending Publication Date: 2026-07-24GUANGXI UNIV OF CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGXI UNIV OF CHINESE MEDICINE
Filing Date
2026-06-29
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

In existing technologies, the application of *Heliotropium indicum* is limited to its antioxidant and anti-inflammatory effects, failing to specifically regulate related biological factors to effectively slow down aging, thus limiting its application in drug development.

Method used

By inhibiting the activity of the PI3K/Akt/mTOR and S6K1 signaling pathways, *Euphorbia hirta* is used in formulations or pharmaceutical compositions to slow down animal cell aging. The crude drug content is 3.75 g/kg to 15 g/kg, and it is administered orally.

Benefits of technology

Yellow water lily significantly delays the aging process of animal cells by inhibiting the activity of these signaling pathways, improving its efficiency in anti-aging drugs and exhibiting antioxidant, anti-inflammatory and anti-apoptotic effects.

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Abstract

The application relates to the technical field of pharmaceutical preparations, in particular to application of Thalia dealbata in inhibiting a PI3K / Akt / mTOR signal path to slow down animal cell aging, which finds that Thalia dealbata can delay body aging after being applied to an aging model, and can slow down the animal cell aging process by inhibiting the activity of the PI3K / Akt / mTOR signal path, and effectively improves the efficiency of Thalia dealbata in slowing down aging.
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