A method for synthesizing a small molecule polyethylene glycol
By using a living polymerization system initiated by 2-methoxyethanol and aluminum alkoxide oxygen coordination, combined with tubular microreactors and cooling crystallization technology, the problems of low end group functionality and difficulty in removing dihydroxyl impurities in the synthesis of small molecule monomethoxy polyethylene glycol were solved, and the synthesis of polyethylene glycol with narrow molecular weight distribution and high purity was achieved.
Patent Information
- Authority / Receiving Office
- CN Β· China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- FUSHUN XIULIN CHEM CO LTD
- Filing Date
- 2026-06-23
- Publication Date
- 2026-07-24
AI Technical Summary
Existing technologies for the synthesis of small molecule monomethoxy polyethylene glycol suffer from problems such as low end-group functionality, difficulty in removing dihydroxyl impurities, and poor batch-to-batch product consistency. In particular, during industrial scale-up, insufficient heat dissipation and uneven mass transfer lead to high dispersion index and insufficient end-group purity.
2-Methoxyethanol was used instead of methanol as the initiator, and an aluminum alcohol oxygen coordination initiation system was used for living polymerization. Impurities were removed by cooling crystallization in a tubular microreactor and post-processing steps. Combined with the stabilization treatment of the aluminum alcohol oxygen coordination initiator and precise control of reaction conditions, living polymerization and the synthesis of high-purity products were achieved.
This technology achieves a narrow molecular weight distribution and high purity of monomethoxy end groups, solving the problems of high dispersion index and insufficient end group purity in existing technologies, and improving the consistency and purity of the product.
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Figure CN122444981A_ABST