Multi-channel experimental box for mouse oblique abdominal muscle electromyography detection

Abstract

The utility model relates to the field of medical experiment equipment, in particular to a multi-channel experiment box for mouse oblique abdominal muscle electromyography detection, which comprises a box body and a box cover, the top surface of the box body is opened, and the box cover is buckled on the box body; the front section of the box body is provided with a box body front end, the box body front end is transparent, the box body, the box cover and the tail plate are made of black semitransparent materials, a partition plate is arranged in the box body, the partition plate is a black coating, and the box body, the box cover and the partition plate are all made of acrylic materials. The length * width * height of the cuboid in the middle section of the box body is 3cm * 3cm * 10cm, the length * width * height of the front end of the box body is 3cm * 3cm * 3cm, and the front end part of the box body is a hollow rectangular pyramid which is used for fixing the head of an experimental mouse. Compared with the prior art, the mouse mood optimization experiment device has the advantages that mouse mood optimization experiment results can be pacified, and the device can be repeatedly used to improve economic benefits.

Description

Technical Field

[0001] The utility model relates to the technical field of medical experimental equipment, in particular to a multi-channel experimental box for myoelectric detection of external oblique muscles of mice. Background Art

[0002] The electromyography of the external oblique muscles is to monitor the electromyographic activity of animals by dilating the intestines. It is currently the most widely used method for evaluating the sensitivity of animal viscera. The experiment was conducted without food or water for 24 hours. Electrodes were pre-implanted into the external oblique muscles of both sides of the mouse under anesthesia. The air bag and catheter were coated with liquid paraffin and carefully inserted through the anus. The catheter was fixed outside the anus at the root of the mouse tail. The end of the air bag was about 2 cm away from the anal verge. The mouse was placed in a fixed cage, and the activity was observed and the data was recorded. The formal experiment began after the mouse woke up and adapted for 30 minutes. The electromyogram of the external oblique muscles of the mouse in a stable state of 30 seconds was first intercepted as the baseline and the basic integral was calculated. Then, the air bag in the mouse colon was pressurized by 20, 40, 60 and 80 mmHg in stages, with each pressurization time of 30 seconds and an interval of 180 seconds between each pressurization. The electromyographic activity of the external oblique muscles of the mouse during pressurization was monitored and recorded.

[0003] There is a utility model patent with the announcement number CN211213676U, "A fixed tube for experimental mice for electromyography of the rectus abdominis", which provides a fixed tube for various sizes of mice to perform electromyography of the rectus abdominis. It includes the front end of the fixed tube, the body of the fixed tube and the tail baffle. The front end of the fixed tube is a hollow semi-elliptical cone for fixing the head of the experimental mouse. The body of the fixed tube is a hollow semi-cylinder for fixing the torso of the experimental mouse. The body of the fixed tube also includes two adjustable arc plates. The disadvantage is that it does not solve the problem of mice being irritable during the experiment and the experiment taking a long time.

[0004] The existing device is used to conduct rectus abdominis electromyography experiments on mice at a certain stage. According to existing literature, each mouse needs to be measured at four gradient pressure values, with an interval of 180 seconds each. It is very time-consuming to conduct four measurements on a single mouse. The entire experimental process needs to be carried out when the mouse is quiet, and the environment in the fully transparent fixed tube will make the mouse irritable and interfere with the experimental progress. Utility Model Content

[0005] In view of this, the purpose of the utility model is to propose a multi-channel experimental box for electromyographic detection of the external oblique muscles of mice, which can calm the emotions of mice and can be used repeatedly at the same time.

[0006] Based on the above purpose, the utility model provides a multi-channel experimental box for electromyographic detection of the external oblique muscles of mice, comprising a box body and a box cover, the top surface of the box body is open, and the box cover is buckled on the box body; the front end of the box body is provided with a box front end, the box front end is transparent, the rectangular body in the middle section of the box body and the box cover are made of black translucent material, and a partition is provided in the box body.

[0007] Preferably, the box body, box cover and partition are all made of acrylic.

[0008] Preferably, the size of the rectangular parallelepiped in the middle section of the box body is 3cm×3cm×10cm in length×width×height.

[0009] Preferably, the dimensions of the front end of the box body are 3cm×3cm×3cm in length×width×height.

[0010] Preferably, the front end portion of the box body is a hollow quadrangular pyramid for fixing the head of the experimental mouse, and the middle portion of the box body is a hollow rectangular parallelepiped for fixing the torso of the experimental mouse.

[0011] Preferably, the partition is coated with black, and there are three partitions.

[0012] Preferably, the front end of the box body is made of transparent material, and a tail plate is provided at one end of the box body.

[0013] Preferably, the box body, box cover and tail plate are made of black translucent material.

[0014] Preferably, a hollowed-out external oblique muscle electromyographic opening is provided at the top front end of the box cover.

[0015] Preferably, a tail groove for the rat tail to pass through is provided in the middle of the seam edge between the tail plate and the middle section of the box body.

[0016] Preferably, the tail plate and the box cover are integrally constructed and directly mounted on the box body, and the second hole and the third hole, the first hole and the fourth hole are formed on both sides of the outer wall of the partition plate and the tail plate.

[0017] Beneficial effects of the utility model:

[0018] 1. This is a multi-channel experimental box for myoelectric detection of external oblique muscles of mice. The lid and tail plate of the utility model are made of black translucent material, which can reduce light while allowing the experimenter to clearly observe the body reaction of the mouse when it is subjected to colon pressure expansion.

[0019] 2. This is a multi-channel experimental box for electromyographic detection of the external oblique muscles of mice. The utility model overcomes the time-consuming problem of electromyographic detection experiments of the external oblique muscles of mice. Using the multi-channel experimental box, multiple mice can be experimented at the same time, and the partition is coated with black, so the mice do not interfere with each other.

[0020] 3. This is a multi-channel experimental box for electromyographic detection of the external oblique muscles of mice. The utility model overcomes the problem of mice being irritable during the experiment. According to the habit of mice to move toward darkness, the body of the experimental box is designed to be black, which conforms to the instinct of mice to move toward darkness and makes them quiet down quickly. The front end of the box is designed to be transparent to utilize the phototaxis of mice to prevent them from retreating backwards out of the experimental box.

[0021] 4. This is a multi-channel experimental box for electromyographic detection of the external oblique muscles of mice. The front end of the experimental box is a hollow quadrangular pyramid and the end is provided with small air holes, which conform to the shape of the head of the experimental mouse, ensuring that the experimental mouse breathes steadily in the fixing device, and can have a certain fixing effect on the experimental mouse. The fixing method is relatively comfortable and suitable for intervention treatment of experimental mice.

[0022] 5. This is a multi-channel experimental box for external oblique muscle electromyography detection in mice. The external oblique muscle electromyography detection opening at the front end of the top of the box body is convenient for exposing the electrode wires on the neck of the experimental mouse and connecting the recording wires of the measuring instrument. The fixing device can reduce the stress response of the experimental mouse and has the advantages of being economical, widely adaptable, and easy to operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only for the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 It is a schematic diagram of the overall three-dimensional structure of the utility model;

[0025] Figure 2 This is a schematic diagram of the three-dimensional structure of the box cover and the box body of the utility model;

[0026] Figure 3 This is a schematic diagram of the three-dimensional structure of the box body and the front end of the box body of the utility model;

[0027] Figure 4 This is a schematic diagram of the three-dimensional structure of the myoelectric opening and tail plate of the utility model;

[0028] Figure 5 For this utility model Figure 3 Schematic diagram of the structure at A in the middle;

[0029] Figure 6 For this utility model Figure 4 Schematic diagram of the structure at point B in the middle.

[0030] The markings in the figure are:

[0031] 1. Box cover; 2. EMG opening; 3. Tail slot; 4. First hole; 5. Second hole; 6. Partition; 7. Box body; 8. Third hole; 9. Front end of box body; 10. Fourth hole; 11. Tail plate. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with specific embodiments.

[0033] It should be noted that, unless otherwise defined, the technical terms or scientific terms used in the present invention should be understood by people with ordinary skills in the field to which the present invention belongs. The words "first", "second" and similar words used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. "Include" or "comprise" and similar words mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, without excluding other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0034] like Figures 1 to 6 As shown, a multi-channel experimental box for electromyographic detection of external oblique muscles of mice comprises a box body 7 and a box cover 1. The top surface of the box body 7 is open, and the box cover 1 is buckled on the box body 7; the quadrangular pyramid at the front end of the box body 7 is transparent, and the quadrangular pyramid is designed to be transparent to utilize the phototaxis of mice to prevent the mice from exiting the experimental box backwards; the rectangular parallelepiped, the box cover and the tail plate in the middle section of the box body 7 are made of black translucent material, and the size of the rectangular parallelepiped in the middle section of the box body 7 is 3cm×3cm×10cm in length×width×height, and a partition 6 is provided in the box body 7, and the box body 7, the box cover 1 and the partition 6 are all made of acrylic, and the partition 6 is black coated. There are three partitions 6, so that multiple mice can be experimented at the same time without interfering with each other;

[0035] In actual use, after placing the mouse into the box, isolate it with a partition 6, take the mouse tail out of the tail groove 3 and place it outside the box, pass the muscle electrode wire of the external oblique muscle of the neck of the exposed experimental mouse through the electromyographic opening 2, and connect it to the conductive clip of the measuring instrument. The experimental box can accommodate 4 mice for experiments at the same time.

[0036] For further information, see Attachment Figure 2 and Figure 3 as well as Figure 5As shown, the front end 9 of the box body is a hollow quadrangular pyramid for fixing the head of the experimental mouse, and the middle part of the box body 7 is a hollow rectangular parallelepiped for fixing the torso of the experimental mouse. The dimensions of the front end quadrangular pyramid of the box body 7 are 3cm×3cm×3cm in length×width×height.

[0037] For further information, see Attachment Figure 2 As shown, the top front end of the box cover 1 is provided with a hollow external oblique muscle electromyographic opening 2, and the experiment is carried out by passing the electrode wire of the external oblique muscle of the neck of the experimental mouse through the electromyographic opening 2 and connecting it to the conductive clip of the measuring instrument.

[0038] For further information, see Attachment Figure 1 and Figure 2 , Figure 6 A tail groove 3 for the mouse's tail to pass through is provided in the middle of the seam edge of the tail plate 11 and the middle part of the box body 7. The tail groove 3 is provided to facilitate the placement of the mouse's tail, thereby preventing the mouse's tail from being placed improperly and causing struggles that affect the progress of the experiment.

[0039] For further information, see Attachment Figure 2 As shown, the tail plate 11 is integrally constructed with the box cover 1 and is directly buckled onto the box body 7. The second hole 5 and the third hole 8, the first hole 4 and the fourth hole 10 are fixed with wires. The second hole 5 and the third hole 8, the first hole 4 and the fourth hole 10 are fixed with wires to prevent the mouse from struggling during the experiment and lifting the box cover 1 and running out of the box body 7.

[0040] Those skilled in the art should understand that the discussion of any of the above embodiments is merely illustrative and is not intended to imply that the scope of the present invention (including the claims) is limited to these examples. Under the concept of the present invention, the technical features in the above embodiments or different embodiments may be combined, the steps may be implemented in any order, and there are many other variations of the different aspects of the present invention as described above, which are not provided in detail for the sake of simplicity.

[0041] The utility model is intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the utility model should be included in the scope of protection of the utility model.

Claims

1. A multi-channel experimental box for myoelectric detection of external oblique muscles of mice, characterized in that: The box body (7) comprises a box body (7) and a box cover (1); the top surface of the box body (7) is open, and the box cover (1) is buckled onto the box body (7); a box body front end (9) is provided at the front end of the box body (7); the box body front end (9) is transparent; the box body (7) and the box cover (1) are made of black translucent material; and a partition (6) is provided inside the box body (7).

2. A multi-channel experimental box for myoelectric detection of mouse external oblique muscles according to claim 1, characterized in that: The box body (7), the box cover (1) and the partition (6) are all made of acrylic.

3. A multi-channel experimental box for myoelectric detection of mouse external oblique muscles according to claim 2, characterized in that: The rectangular parallelepiped size of the middle section of the box body (7) is 3 cm in length × 3 cm in width × 10 cm in height.

4. A multi-channel experimental box for myoelectric detection of mouse external oblique muscles according to claim 1, characterized in that: The dimensions of the front end (9) of the box body are 3 cm in length × 3 cm in width × 3 cm in height.

5. A multi-channel experimental box for myoelectric detection of mouse external oblique muscles according to claim 4, characterized in that: The front end (9) of the box body is a hollow quadrangular pyramid for fixing the head of the experimental mouse, and the middle section of the box body is a hollow rectangular parallelepiped for fixing the torso of the experimental mouse.

6. A multi-channel experimental box for myoelectric detection of external oblique muscles of mice according to claim 1, characterized in that: The partition (6) is coated with a black coating, and there are three partitions (6).

7. A multi-channel experimental box for myoelectric detection of external oblique muscles of mice according to claim 1, characterized in that: The front end (9) of the box body is made of a transparent material, and one end of the box cover (1) is provided with a tail plate (11), which is made of a black translucent material.

8. A multi-channel experimental box for myoelectric detection of external oblique muscles of mice according to claim 1, characterized in that: The top front end of the box cover (1) is provided with a hollowed-out external oblique muscle electromyographic opening (2).

9. A multi-channel experimental box for myoelectric detection of external oblique muscles of mice according to claim 7, characterized in that: A tail groove (3) for the rat's tail to pass through is provided in the middle of the seam edge between the tail plate (11) and the middle section of the box body.

10. A multi-channel experimental box for myoelectric detection of external oblique muscles of mice according to claim 7, characterized in that: The tail plate (11) and the box cover (1) are integrally constructed and directly mounted on the box body (7). The second hole (5) and the third hole (8), the first hole (4) and the fourth hole (10) are formed on both sides of the outer wall of the partition plate (6) and the tail plate (11).

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