Leukocyte-depleted blood bag combined bag

Abstract

The utility model belongs to the field of blood component separation, and particularly relates to a leukocyte-depleted blood bag combined bag. The blood bag connecting bag comprises a blood sampling bag, the top of the blood sampling bag is connected with a first transfer bag through a first transfer pipe, the top of the blood sampling bag is sequentially connected with a second transfer bag and a third transfer bag through a second transfer pipe, and a leukocyte-depleting filter is arranged on the first transfer pipe and located between the blood sampling bag and the first transfer bag. According to the application, the transfer tube is arranged at the top to realize the transfer of the plasma, the albuginea layer and the red blood cells, the plasma and the albuginea layer share one transfer tube and are transferred to the corresponding transfer bag for storage, the transfer tube corresponding to the red blood cells is provided with the leukocyte-depleting filter, the albuginea layer contains platelets, and subsequent component preparation of the platelets can be carried out; the red blood cells are transferred into the first transfer bag through the first transfer tube to be stored, so that blood platelets are effectively prepared and reserved, and blood components are prevented from being lost.

Description

Technical Field

[0001] The present application belongs to the field of blood component separation, and specifically relates to a leukocyte-removed blood bag combination bag. Background Art

[0002] Blood transfusion remains an essential and irreplaceable clinical treatment. Leukoreduction of blood components can improve their shelf life, reduce febrile non-hemolytic reaction (FNHTR), prevent or delay HLA alloimmunization, and reduce numerous adverse reactions, including post-transfusion graft-versus-host disease (GVHD). Therefore, leukoreduction is the preferred method for blood component transfusion.

[0003] Currently, when blood bags are used for leukocyte filtration, whole blood is directly passed through a leukocyte removal filter to remove leukocytes. Since platelets have strong adhesion, they can evenly adhere to the filter screen and are first retained, resulting in a large loss of platelets after leukocyte filtration.

[0004] Therefore, there is an urgent need for a leukocyte-reduced blood bag combination bag that can effectively prepare and retain platelets. Utility Model Content

[0005] The purpose of the present application is to provide a leukocyte-reduced blood bag combination bag for effectively preparing and retaining platelets.

[0006] The embodiments of the present application can be implemented through the following technical solutions:

[0007] A leukocyte-reduced blood bag combination bag includes a blood collection bag, the top of the blood collection bag is connected to a first transfer bag via a first transfer tube, and the top is sequentially connected to a second transfer bag and a third transfer bag via a second transfer tube, a leukocyte-reduced filter is provided on the first transfer tube, and the leukocyte-reduced filter is located between the blood collection bag and the first transfer bag.

[0008] Preferably, a dripping bucket is further included, which is located between the blood collection bag and the first transfer bag, and its two ends are respectively connected to the first transfer tube.

[0009] Preferably, it further comprises an exhaust pipeline, and the axial ends of the exhaust pipeline are connected to the two ends of the leukocyte removal filter through a tee pipe.

[0010] Furthermore, a flow-stop clamp is provided on the exhaust pipe.

[0011] Furthermore, a second blocking device is provided between the blood collection bag and the first transfer tube.

[0012] Furthermore, a blood transfusion port is provided on the top of the first transfer bag.

[0013] Preferably, a fourth transfer bag is further included, and the fourth transfer bag is arranged in parallel with the third transfer bag.

[0014] Furthermore, the second transfer bag and the third transfer bag are respectively connected to the second transfer pipe through a tee pipe.

[0015] Furthermore, the top of the blood collection bag is connected to the sampling device and the puncture needle through a blood collection tube, and a pipe tee is provided between the blood collection tube, the sampling device and the puncture needle.

[0016] Furthermore, the blood collection tube is provided with a flow-stop clamp and / or a first blocking device.

[0017] The embodiment of the present application provides a leukocyte-reduced blood bag combination bag having at least the following beneficial effects:

[0018] The present application realizes the transfer of plasma, buffy coat layer and red blood cells by setting a transfer tube at the top, and the plasma and buffy coat layer share a transfer tube and are transferred to corresponding transfer bags for storage. The transfer tube corresponding to the red blood cells is provided with a leukocyte removal filter. The buffy coat layer contains platelets, which can be used for subsequent platelet component preparation. The red blood cells are transferred to the first transfer bag for storage through the first transfer tube, thereby achieving effective preparation and retention of platelets and preventing the loss of blood components.

[0019] The drip bucket in this application can filter impurities, blood clots and other impurities in the red blood cells after centrifugation to ensure the preparation effect of leukocyte-reduced red blood cells;

[0020] The exhaust pipe in the present application can allow the red blood cells after centrifugation to be filtered smoothly through the leukocyte removal filter and enter the first transfer bag, while exhausting the excess gas in the first transfer bag;

[0021] In the present application, secondary preparation of plasma or buffy coat can also be achieved, and the fourth transfer bag can be used to store plasma cryoprecipitated coagulation factors or platelet-rich plasma for a short period of time. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the structure of the leukocyte-reduced blood bag combination bag in this application.

[0023] Figure numerals: 1. sampling device, 3. first blocking device, 5. puncture needle, 6. blood collection tube, 7. second blocking device, 8. first transfer tube, 9. second transfer tube, 11. drip bucket, 13. leukocyte removal filter, 14. exhaust pipe, 16. blood transfusion port, 17. first transfer bag, 18. fourth transfer bag, 19. third transfer bag, 20. second transfer bag, 21. blood collection bag, 22. third blocking device. DETAILED DESCRIPTION

[0024] Hereinafter, the present application will be further described based on preferred embodiments with reference to the accompanying drawings.

[0025] The terms used in this specification are intended to illustrate the embodiments of this application and are not intended to limit this application. Unless otherwise specified or limited, the terms "disposed," "connected," and "connected" should be understood broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections, direct connections, indirect connections through an intermediate medium, or internal connections between two components. Those skilled in the art will have a clear understanding of the specific meanings of the above terms in this application.

[0026] In addition, in the description of the embodiments of the present application, various components on the drawings are enlarged or reduced in size for ease of understanding, but this practice is not intended to limit the scope of protection of the present application.

[0027] The present application provides a leukocyte-reduced blood bag combination bag, Figure 1 The schematic diagram of the structure of the leukocyte-reduced blood bag combination bag in this application is shown as follows: Figure 1 As shown, the blood bag combination bag includes a blood collection bag 21, the top of the blood collection bag 21 is connected to the first transfer bag 17 through the first transfer tube 8, and the top is connected to the second transfer bag 20 and the third transfer bag 19 in sequence through the second transfer tube 9. The blood collection bag 21 containing whole blood is placed in a centrifuge for centrifugation. According to the different specific gravities of each blood component, stratification will occur, which includes plasma, buffy coat layer and red blood cells from top to bottom. The plasma in the upper layer is transferred to the second transfer bag 20 or the third transfer bag 19 through the second transfer tube 9 for storage, and the buffy coat layer is transferred to the third transfer bag 19 or the second transfer bag 20 for storage through the second transfer tube 9. The buffy coat layer contains platelets, which can be used for subsequent platelet component preparation. The red blood cells are transferred to the first transfer bag 17 through the first transfer tube 8 for storage, thereby achieving effective preparation and retention of platelets and preventing the loss of blood components.

[0028] Furthermore, a leukocyte-removing filter 13 is provided on the first transfer tube 8. The leukocyte-removing filter 13 is located between the blood collection bag 21 and the first transfer bag 17, which can effectively filter the white blood cells in the red blood cells, ensuring that the red blood cells prepared in the first transfer bag 17 are leukocyte-removed suspended red blood cells.

[0029] In some preferred embodiments of the present application, a flow-stop clamp is provided on the connecting pipeline between the leukocyte depletion filter 13 and the first transfer bag 17 .

[0030] In some preferred embodiments of the present application, the blood bag connection bag also includes a dripping bucket 11, which is located between the blood collection bag 21 and the first transfer bag 17. Its two ends are respectively connected to the first transfer tube 8, which can filter impurities, blood clots and other impurities in the red blood cells after centrifugation to ensure the preparation effect of leukocyte-reduced red blood cells.

[0031] In some specific embodiments of the present application, the drip chamber 11 includes a blood filter to filter out impurities.

[0032] In some preferred embodiments of the present application, the blood bag connection bag also includes an exhaust pipe 14, and the axial ends of the exhaust pipe 14 are connected to the two ends of the leukocyte removal filter 13 through a tee pipe fitting, so that the red blood cells after centrifugation can be smoothly filtered through the leukocyte removal filter 13 and enter the first transfer bag 17, while exhausting excess gas in the first transfer bag 17.

[0033] In some preferred embodiments of the present application, a flow-stop clamp is provided on the exhaust pipe 14 to control the on-off of the exhaust pipe 14 .

[0034] In some preferred embodiments of the present application, the blood collection bag 21 is filled with a blood preservation solution, which can prevent blood coagulation, maintain the pH value of the blood, ensure the respiration and metabolism of blood cells in the whole blood, and achieve short-term preservation.

[0035] In some preferred embodiments of the present application, the first transfer bag 17 contains red blood cell preservation solution, which is beneficial to the metabolism and short-term preservation of red blood cells.

[0036] In some preferred embodiments of the present application, a second blocking device 7 is provided between the blood collection bag 21 and the first transfer tube 8 for controlling the passage of red blood cells to ensure the controllability and efficiency of the preparation.

[0037] In some preferred embodiments of the present application, a liquid filling pipeline is provided on the top of the blood collection bag 21 .

[0038] In some preferred embodiments of the present application, a blood transfusion port 16 is provided on the top of the first transfer bag 17 .

[0039] In some preferred embodiments of the present application, a liquid filling pipeline is provided on the top of the first transfer bag 17 .

[0040] In some preferred embodiments of the present application, the blood bag chain further includes a fourth transfer bag 18, which is arranged in parallel with the third transfer bag 19 and the second transfer bag 20. The fourth transfer bag 18 can be used for secondary preparation of plasma or buffy coat, and can be used for short-term storage of plasma cryoprecipitated coagulation factors or platelet-rich plasma. It is conceivable that multiple transfer bags can be provided to facilitate the transfer of multiple blood components.

[0041] Furthermore, the second transfer bag 20 and the third transfer bag 19 are respectively connected to the second transfer tube 9 through the pipe tees to achieve smooth transfer of blood components.

[0042] In some specific embodiments of the present application, the second transfer bag 20 and the third transfer bag 19 are connected to the tee pipe through a connecting pipeline, and a liquid stop clamp is provided on the connecting pipeline to control the flow of liquid.

[0043] In some specific embodiments of the present application, a blood transfusion port 16 is provided on the top of the second transfer bag 20 and the third transfer bag 19 .

[0044] Furthermore, the top of the blood collection bag 21 is connected to the sampling device 1 and the puncture needle 5 through the blood collection tube 6, and a pipe tee is provided between the blood collection tube 6 and the sampling device 1 and the puncture needle 5.

[0045] In some specific embodiments of the present application, the sampling device 1 includes a sampling needle tube, a protective sleeve, a hand-held sheath, a needle seat, a needle handle, a connecting pipeline, a sampling bag and a flow-stop clamp, etc.

[0046] Furthermore, the blood collection tube 6 is provided with a flow-stop clamp and / or a first blocking device 3 .

[0047] During blood collection, the venipuncture needle 5 punctures the human body, the stopcock and first blocking device 3 of the sampling device 1 are opened, and the whole blood is sampled and stored in the sampling device 1. The whole blood then flows through the blood collection tube 6 into the blood collection bag 21 for storage. The blood collection bag 21 containing the whole blood is then placed in a centrifuge for centrifugation, and the plasma, buffy coat, and red blood cells are separated from the blood in a centrifuge. The upper plasma is transferred to the second transfer bag 20 or the third transfer bag 19 for storage via the second transfer tube 9, and the buffy coat is transferred to the third transfer bag 19 or the second transfer bag 20 for storage via the second transfer tube 9. The buffy coat contains platelets, which can be used for subsequent platelet component preparation. The remaining concentrated red blood cells in the blood collection bag 21 will flow through the first transfer tube 8 through the drip chamber 11 and the leukocyte removal filter 13, where the corresponding impurities, blood clots, and leukocytes are removed. The leukocyte-removed concentrated red blood cells then enter the first transfer bag 17, which contains a red blood cell preservation solution that facilitates the metabolism and short-term storage of the red blood cells. In addition, the blood bag-linked structure can also realize secondary preparation of plasma or buffy coat, and the fourth transfer bag 18 can store plasma cryoprecipitated coagulation factors or platelet-rich plasma for a short period of time.

[0048] The above is a detailed introduction to the specific implementation methods of the present application. For those skilled in the art, several improvements and modifications can be made to the present application without departing from the principles of the present application. These improvements and modifications also fall within the scope of protection of the claims of the present application.

Claims

1. A leukocyte-reduced blood bag combination, comprising a blood collection bag, characterized in that: The top of the blood collection bag is connected to the first transfer bag through a first transfer tube, and the top is connected to the second transfer bag and the third transfer bag in sequence through a second transfer tube. A leukocyte removal filter is provided on the first transfer tube, and the leukocyte removal filter is located between the blood collection bag and the first transfer bag.

2. The leukocyte-reduced blood bag combination according to claim 1, characterized in that: It also includes a dripping bucket, which is located between the blood collection bag and the first transfer bag, and its two ends are respectively connected to the first transfer tube.

3. The leukocyte-reduced blood bag combination according to claim 1, characterized in that: It also includes an exhaust pipeline, and the axial ends of the exhaust pipeline are connected to the two ends of the leukocyte removal filter through a tee pipe.

4. The leukocyte-reduced blood bag combination according to claim 3, characterized in that: A flow-stop clamp is provided on the exhaust pipe.

5. The leukocyte-reduced blood bag combination according to claim 1, characterized in that: A second blocking device is provided between the blood collection bag and the first transfer tube.

6. The leukocyte-reduced blood bag combination according to claim 1, characterized in that: A blood transfusion socket is provided on the top of the first transfer bag.

7. The leukocyte-reduced blood bag combination according to claim 1, characterized in that: It also includes a fourth transfer bag, which is arranged in parallel with the third transfer bag.

8. The leukocyte-reduced blood bag combination according to claim 1, characterized in that: The second transfer bag and the third transfer bag are respectively connected to the second transfer pipe through a tee pipe.

9. The leukocyte-reduced blood bag combination according to claim 1, characterized in that: The top of the blood collection bag is connected to the sampling device and the puncture needle through a blood collection tube, and a pipe tee is provided between the blood collection tube, the sampling device and the puncture needle.

10. The leukocyte-reduced blood bag combination according to claim 9, characterized in that: The blood collection tube is provided with a flow-stop clamp and / or a first blocking device.

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