Vacuum concentration system suitable for extract containing unstable components

Abstract

The utility model discloses a vacuum concentration system suitable for an extract containing unstable components. The vacuum concentration system comprises a nitrogen generator, a nitrogen buffer tank, a vacuum drying box and a vacuum pump, the vacuum drying box comprises a box body, a heating structure arranged in the box body, a hollow storage rack, a sample storage tank, a switch door arranged on the box body, an air inlet A formed in the upper part of the box body and an air outlet A formed in the lower part of the box body; a hygrothermograph is further installed in the box body, and a temperature controller in signal connection with the heating structure and the hygrothermograph and a vacuum display meter used for displaying the vacuum degree in the box body are further arranged on one side of the box body. According to the utility model, through circulating vacuum and nitrogen treatment, the volatilization temperature point of moisture or solvent is reduced by utilizing vacuum, and the volatilized moisture or solvent is taken away by utilizing nitrogen purging treatment, so that the time for concentrating and drying the sample is greatly shortened, and the property of the sample is prevented from changing.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the vacuum concentration equipment field of extract, specifically relates to a vacuum concentration system suitable for containing unstable component extract. BACKGROUND

[0002] At present, for the vacuum concentration of containing unstable component extract, the temperature-controllable vacuum drying box is adopted. The water content or solvent boiling point in the material is reduced by using the vacuum environment, so that the high-efficiency drying equipment is realized. In addition, in order to shorten the vacuum drying time, the temperature is increased to 50-100 DEG C. Although the drying time is shortened by increasing the temperature, the concentration and drying of containing unstable component extract cannot be met. The structure of unstable component is changed after contacting with oxygen under the high temperature. And the vacuum concentration time is too long without increasing the temperature. SUMMARY

[0003] The utility model discloses a vacuum concentration system suitable for containing unstable component extract to solve the deficiency of the prior art.

[0004] In order to realize the above-mentioned purpose, the utility model provides the following technical scheme: a vacuum concentration system suitable for containing unstable component extract, including nitrogen generator, nitrogen buffer tank, vacuum drying box and vacuum pump, wherein,

[0005] The vacuum drying box includes a box body, a heating structure arranged in the box body, a hollow storage rack installed in the box body, a sample storage tank freely taken out of the box body and arranged on the hollow storage rack, a switch door arranged on the box body, an air inlet A arranged on the upper part of the box body and an air outlet A arranged on the lower part of the box body. A hygrometer is also installed in the box body. A temperature controller connected with the heating structure and the hygrometer and a vacuum display table for displaying the vacuum degree in the box body are arranged on one side of the box body.

[0006] The air outlet C of the nitrogen generator is communicated with the air inlet B of the nitrogen buffer tank through a pipeline. The air outlet B of the nitrogen buffer tank is communicated with the air inlet A of the vacuum drying box through a pipeline. The air outlet A of the vacuum drying box is communicated with the vacuum pump through a pipeline.

[0007] Further, a storage groove is arranged on the upper part and the lower part of the box body respectively, and an adsorbent is arranged in the storage groove.

[0008] Further, the number of the hollow storage racks installed in the box body is at least three, and the hollow storage racks are arranged longitudinally. The sample storage tank is of a rectangular structure, and the height of the baffle around the sample storage tank is 3cm.

[0009] Further, a valve is installed on the pipeline connecting the nitrogen generator with the nitrogen buffer tank, on the pipeline connecting the nitrogen buffer tank with the vacuum drying box, and on the pipeline connecting the vacuum drying box with the vacuum pump.

[0010] Further, the heating structure is arranged along the inner wall of the box body.

[0011] The present application has the following beneficial effects:

[0012] (1) The volatile water or solvent is taken away while the volatile water or solvent is accelerated to volatilize, and the concentration or drying time is shortened;

[0013] (2) The volatile gas in the vacuum drying box is treated by inputting nitrogen, so that the property of the sample is prevented from changing;

[0014] (3) The temperature of the present application is controlled at 20-50 DEG C to assist the volatilization of water or solvent, so that the unstable components in the sample are protected after treatment, and the volatile effect is also achieved. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 The present application has the following beneficial effects: DETAILED DESCRIPTION

[0016] The embodiments of the present application will be described below with reference to the accompanying drawings, and those skilled in the art will understand that the following embodiments are only used to illustrate the present application, and should not be regarded as limiting the scope of the present application. In the embodiments, the specific technology, connection relationship or condition not mentioned is described according to the technology, connection relationship, condition described in the literature in the art or according to the product instruction. The materials, instruments or equipment not mentioned by the manufacturer are all conventional products that can be obtained by purchase.

[0017] In the description of the present application, it should be pointed out that, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "provided with" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium. For those skilled in the art, the specific meaning of the above terms in the present application should be understood according to the specific circumstances.

[0018] As shown in Figure 1 The present application provides a vacuum concentration system suitable for extract containing unstable components, which comprises a nitrogen generator 1, a nitrogen buffer tank 2, a vacuum drying box 3 and a vacuum pump 4.

[0019] The vacuum drying oven 3 comprises a box body 301, a heating structure 302 arranged in the box body 301, a hollow storage rack 303 arranged in the box body 301, a sample storage tank 304 freely taken out of the box body and arranged on the hollow storage rack 303, an opening and closing door 305 arranged on the box body 301, an air inlet A 306 arranged on the upper part of the box body 301, and an air outlet A 307 arranged on the lower part of the box body 301; the air inlet A 306 is located at the right rear upper part of the box body 301, and the air outlet A 307 is located at the left rear lower part of the box body 301; a temperature and humidity meter 308 is further arranged in the box body 301, and a temperature controller 309 connected with the heating structure 302 and the temperature and humidity meter 308 in signal and a vacuum display table 310 used for displaying the vacuum degree in the box body 301 are further arranged on one side of the box body; the heating structure 302 is arranged along the inner wall of the box body; the opening and closing door 305 is tightly connected with the box body 301 through a door buckle 312; during the sample processing, the temperature can be adjusted by the heating structure 302 controlled by the temperature controller 309, so as to shorten the processing time.

[0020] The air outlet C 15 of the nitrogen generator 1 is communicated with the air inlet B 201 of the nitrogen buffer tank 2 through a pipeline, the air outlet B 202 of the nitrogen buffer tank 2 is communicated with the air inlet A 306 of the vacuum drying oven 3 through a pipeline, and the air outlet A 307 of the vacuum drying oven 3 is communicated with the vacuum pump 4 through a pipeline; the pipelines connected with the nitrogen generator 1, the nitrogen buffer tank 2 and the vacuum drying oven 3 are respectively provided with a valve, i.e., a first valve 5, a second valve 6 and a third valve 7.

[0021] Specifically, the number of the hollow storage racks 303 arranged in the box body 301 is at least three and arranged in longitudinal direction; the number of the sample storage tanks 304 freely taken out is also at least three; the sample storage tank 304 has a rectangular structure, the height of the baffle around the sample storage tank 304 is 3 cm, the sample is placed in the sample storage tank 304, and the laying thickness is 0.2-1 cm, so that the sample vacuum foaming overflow can be prevented; a storage groove 311 containing an adsorbent is further arranged at the upper and lower parts of the box body 301, the adsorbent can be selected according to the sample dissolving agent, if the water is volatilized in the sample, the color-changing silica gel or zeolite molecular sieve or activated alumina can be put in; if the organic matter is volatilized in the sample, the activated carbon or zeolite molecular sieve can be put in; the sample storage tank 304 is arranged between the two storage grooves 311.

[0022] The nitrogen generator is a very mature device in the market, and its working principle is that air enters into a compression and pretreatment system 11 through an air inlet C14, the air is pressurized and moisture and oil are removed, then enters into a nitrogen separation system 12 through an internal pipeline, nitrogen is separated out by using internal molecular sieve, then enters into a nitrogen separation and purification system 13 through an internal pipeline, residual impurities are removed through a precision filter, and finally high-purity nitrogen is obtained. The high-purity nitrogen is discharged from a gas outlet C15 and stored in a nitrogen buffer tank 2.

[0023] The utility model discloses a vacuum concentration or vacuum drying is carried out to sample, and the superfluous moisture or solvent is removed, and the sample is handled to be called vacuum drying if powder, and it is called vacuum concentration if residual liquid, and the solid content of general extract (sample) is concentrated or dried preferably and is better. The device is to retain the unstable material in the sample, for example: paclitaxel in the concentrated and dried terpenoid compound, artemisinin, anthocyanin in phenolic and polyphenol, vinblastine in alkaloid, and these materials are easy to be decomposed and oxidized when heated.

[0024] The working steps of the utility model are as follows:

[0025] (1) N2 generated in the nitrogen generator 1 enters the nitrogen buffer tank 2.

[0026] (2) the sample is placed in the sample storage groove 304 of the vacuum drying box 3, and the switch door 305 is closed tightly through the door buckle 312.

[0027] (3) the second valve 6 is closed, the vacuum pump 4 is opened to draw vacuum, when the value displayed on the vacuum display table 310 reaches about -0.08MPa, the third valve 7 associated with the gas outlet A307 of the vacuum drying box 3 is closed.

[0028] (4) after the vacuum state lasts for 0.5-2h, the second valve 6 is opened, N2 enters the vacuum drying box 3 through the air inlet A306, and the pressure of the vacuum drying box is in a non-vacuum state at this time.

[0029] (5) the vacuum pump 4 and the third valve 7 are continuously or intermittently opened according to the need, the nitrogen in the vacuum drying box is replaced, and the process is maintained for 5min-30min.

[0030] (6) the second valve 6 is closed until the pressure value displayed on the vacuum display table 310 is -0.08MPa, the third valve 7 is closed, and then the vacuum pump 4 is closed.

[0031] The above steps are repeated for several cycles to achieve a more desirable result. In a vacuum, the extraction liquid will have bubbles generated, and some special samples will have a phenomenon of foaming and swelling. Repeating several cycles shortens the time of concentration and drying to prevent the deterioration of unstable substances.

[0032] The above merely provides the preferred embodiment of the present application, and the protection scope of the present application is not limited thereto. Any skilled person in the art, according to the technical scheme and the inventive concept of the present application, makes equivalent replacement or change within the technical range disclosed by the present application, which shall be covered within the protection scope of the present application.

Claims

1. A vacuum concentration system suitable for extracts containing unstable components, characterized in that, It includes a nitrogen generator (1), a nitrogen buffer tank (2), a vacuum drying oven (3), and a vacuum pump (4); among which, The vacuum drying oven (3) includes a chamber (301), a heating structure (302) installed inside the chamber (301), a hollow shelf (303) installed inside the chamber (301), a sample storage slot (304) placed on the hollow shelf (303) and freely removable, a switch door (305) installed on the chamber (301), an air inlet A (306) located at the top of the chamber (301), and an air outlet A (307) located at the bottom of the chamber (301); a thermometer and hygrometer (308) are also installed inside the chamber (301), and a temperature controller (309) connected to the heating structure (302) and the thermometer and hygrometer (308) and a vacuum display meter (310) for displaying the vacuum level inside the chamber (301) are also provided on one side of the chamber. The outlet C (15) of the nitrogen generator (1) is connected to the inlet B (201) of the nitrogen buffer tank (2) through a pipe. The outlet B (202) of the nitrogen buffer tank (2) is connected to the inlet A (306) of the vacuum drying oven (3) through a pipe. The outlet A (307) of the vacuum drying oven (3) is connected to the vacuum pump (4) through a pipe.

2. The vacuum concentration system for extracts containing unstable components according to claim 1, characterized in that, An adsorbent is provided in the upper and lower parts of the box (301).

3. A vacuum concentration system suitable for extracts containing unstable components according to claim 1 or 2, characterized in that, The number of hollow shelves (303) installed in the box (301) is at least three, arranged in a longitudinal direction; the sample storage tank (304) is a rectangular structure, and the height of the baffles around it is 3cm.

4. The vacuum concentration system for extracts containing unstable components according to claim 1, characterized in that, Valves are installed on the pipes connecting the nitrogen generator (1) and the nitrogen buffer tank (2), the pipes connecting the nitrogen buffer tank (2) and the vacuum drying oven (3), and the pipes connecting the vacuum drying oven (3) and the vacuum pump (4).

5. A vacuum concentration system suitable for extracts containing unstable components according to claim 1, characterized in that, The heating structure (302) is installed along the inner wall of the box.

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