Dissolving device for purifying nicergoline impurity E
By designing a heating element adapted to the rotating flask and a dissolution device with an electromagnetically driven arm, the problem of unstable placement of the rotating flask was solved, the purification efficiency of nicergoline impurity E was improved, and the operation process was simplified.
Patent Information
- Application Number
- CN202520729431.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-17
- Publication Date
- 2026-03-20
- Estimated Expiration
- 2035-04-17
AI Technical Summary
The flat-bottomed container of a traditional shaker cannot be stably placed on the spherical rotating flask in the lower middle part, which leads to an increase in the number of operation steps and a decrease in efficiency during the purification of nicergoline impurity E.
A dissolving device including a heating element and a retaining arm was designed. The retaining arm is driven by an electromagnet and gravity to stabilize the rotating bottle. The retaining arm can rotate to close and open, adapting to the spherical structure of the rotating bottle. Combined with a vibration motor, it can achieve uniform shaking of the mixture.
It achieves stable placement of rotating flasks, reduces operation steps, improves purification efficiency, and has a simple structure and small size, allowing for the simultaneous placement of more rotating flasks.
Smart Images
Figure CN224009639U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to pharmaceutical instrument technical field, concretely relates to a kind of dissolution device for purification of nicergoline impurity E. BACKGROUND
[0002] Nicergoline impurity E, namely 10-hydroxy nicergoline.
[0003] Nicergoline impurity E is insoluble in water, so it needs to be dissolved in advance using organic solvent in its purification process; after purification, organic solvent needs to be removed using rotary evaporator, and the rotary bottle compatible with rotary evaporator is usually spherical in middle and lower parts to increase heating area and improve evaporation speed (the mixture of nicergoline impurity E and organic solvent is adhered to the inner wall of rotary bottle for heating).
[0004] In traditional technology, nicergoline impurity E raw material and organic solvent (such as dichloromethane, acetone) need to be mixed at a specific temperature and shaken evenly using a shaking table to achieve complete dissolution. However, the bottle container compatible with traditional shaking table is usually flat bottom structure (for stable placement) instead of spherical bottom structure, so the mixture in flat bottom container needs to be poured into rotary bottle with spherical middle and lower parts and washed multiple times (to avoid material loss of nicergoline impurity E caused by adhesion of mixture to the inner wall of flat bottom container), which increases operation steps and reduces efficiency. SUMMARY
[0005] To overcome the problem of "rotary bottle with spherical middle and lower parts cannot be stably placed on traditional shaking table" in the above background technology, the utility model provides a dissolution device for purification of nicergoline impurity E.
[0006] The technical solution adopted by the utility model to solve the above technical problem is:
[0007] A dissolution device for purification of nicergoline impurity E, comprising a base, a compression spring installed on the upper surface of the base and standing, a workbench installed on the upper end of the compression spring, and a vibration motor installed on the lower surface of the workbench; the workbench comprises a bottom plate, a top plate above the bottom plate, and a standing support plate; the standing support plate is placed between the bottom plate and the top plate; the standing support plate is vertically fixedly connected to the top plate at the top end and to the bottom plate at the bottom end; the top plate is provided with a circular hole, and a heating sheet driven by electricity is arranged in the circular hole; the heating sheet is in the form of a hemispherical shell structure, and the outer edge of the heating sheet is fixedly connected to the top plate; the top plate is provided with a plug-in hole, and a clamping arm is rotatably connected in the plug-in hole; the top end of the clamping arm can press and connect a rotary bottle spherical in middle and lower parts and placed in the heating sheet.
[0008] As a further optimization scheme of the utility model, the embracing arm further comprises an extension part, the extension part is fixedly arranged at the end of the counterweight part away from the insertion part, and the extension part and the counterweight part are fixedly connected in a 7-shaped manner.
[0009] As a further optimization scheme of the utility model, the insertion part comprises a first rod body and a second rod body fixedly connected in a 7-shaped manner, the first rod body is connected with the fitting part, and the second rod body is connected with the counterweight part.
[0010] A rotating shaft is arranged at the middle part of the second rod body and connected with the inner side wall of the insertion hole.
[0011] As a further optimization scheme of the utility model, the embracing arm further comprises an extension part, the extension part is fixedly arranged at the end of the counterweight part away from the insertion part, and the extension part and the counterweight part are fixedly connected in a 7-shaped manner.
[0012] As a further optimization scheme of the utility model, the insertion part and the extension part are arranged on both sides of the counterweight part.
[0013] As a further optimization scheme of the utility model, the side wall of the vertical supporting plate is provided with an electromagnet, the electromagnet can attract the counterweight part to drive the embracing arm to rotate, and the fitting part is pressed and connected to limit the rotary bottle.
[0014] As a further optimization scheme of the utility model, the side wall of the vertical supporting plate away from the electromagnet is provided with a back supporting rod, the side wall of the back supporting rod is connected with the side wall of the vertical supporting plate in a fitting manner, the top end of the back supporting rod is fixedly connected with the top plate, and the bottom end of the back supporting rod is fixedly connected with the bottom plate.
[0015] As a further optimization scheme of the utility model, the embracing arm is arranged at the outer periphery of the heating sheet in a plurality of and arranged in a circular array with equal intervals and equal angles.
[0016] As a further optimization scheme of the utility model, the counterweight part and the extension part are made of iron-containing metal materials.
[0017] As a further optimization scheme of the utility model, a supporting seat is arranged below the heating sheet, and the top and bottom surfaces of the supporting seat are fixedly connected with the heating sheet and the bottom plate respectively.
[0018] As a further optimization scheme of the utility model, the embracing arm is arranged at the outer periphery of the heating sheet in a plurality of and arranged in a circular array with equal intervals and equal angles.
[0019] (1) The utility model discloses simple structure, reliable function, and the workbench includes the top plate, and the round hole of top plate installs the heating sheet, and the heating sheet is the hemispherical shell structure, thereby for accommodating the lower part spherical part of rotary bottle, and the rotary bottle bottom outer wall can be adapted to the inwall of heating sheet and is pasted together, thereby realize the stable placement of rotary bottle, avoid the rotary bottle to dump.
[0020] (2) The arm can be rotated to realize buckling and opening, and the arm is buckled, and the rotary bottle is pressed by the abutting part, so that the rotary bottle is prevented from bouncing out of the heating sheet when the workbench vibrates, and the stability of the rotary bottle is improved, and the rotary bottle can be conveniently placed into the heating sheet or taken out of the heating sheet in the open state.
[0021] (3) When the electromagnet is powered on, the counterweight part can be attracted to drive the arm to rotate, so that the abutting part is pressed and limited to the rotary bottle, and the arm is buckled, and when the electromagnet is powered off, the counterweight block drives the arm to rotate as a whole under the action of gravity, so that the arm is opened. Compared with the traditional technology adopting the worm gear, the electromagnet and gravity principle are adopted in the utility model, the buckling / opening speed is faster, the volume is smaller, more heating sheets can be installed on the workbench, and more rotary bottles can be placed.
[0022] (4) The extension part and the counterweight part are fixedly connected in the shape of 7. The extension part and the counterweight part can be attracted by the electromagnet at the same time, so that the driving force is improved, the side wall of the extension part and the end face of the counterweight part are flush, and in the adsorption state, the side wall of the extension part and the end face of the counterweight part are pasted with the electromagnet, so that the contact area is increased, the adsorption stability is improved, and it is further ensured that the abutting part can stably press and connect the rotary bottle without being separated and bouncing. BRIEF DESCRIPTION OF DRAWINGS
[0023] The application will be further described below in combination with the drawings:
[0024] Figure 1 It is the overall structure front view schematic diagram of the utility model;
[0025] Figure 2 It is the workbench vertical section front view structure schematic diagram;
[0026] Figure 3 It is the arm open state schematic diagram;
[0027] Figure 4 It is the plug-in hole position and structure schematic diagram;
[0028] Figure 5 It is the arm structure schematic diagram;
[0029] Figure 6 It is the back support rod installation position plan view schematic diagram.
[0030] Explanation of reference numerals in the attached figures:
[0031] In the picture,
[0032] 1. Base;
[0033] 2. Compression spring;
[0034] 3. Workbench; 31. Base plate; 311. Support base; 32. Top plate; 321. Round hole; 322. Heating element; 323. Insertion hole; 324. Arm; 3241. Fitting part; 32411. Elastic friction layer; 3242. Insertion part; 32421. First rod; 32422. Second rod; 3243. Counterweight; 3244. Extension part; 33. Vertical support plate; 331. Electromagnet; 332. Back support rod;
[0035] 4. Vibration motor;
[0036] 5. Rotate the bottle. Detailed Implementation
[0037] Based on the above-described structural features of this application, the implementation methods of this application will be further described as follows:
[0038] Reference Figure 1 This embodiment provides a dissolving apparatus for purifying nicergoline impurity E, including a base 1, a compression spring 2 mounted on the upper surface of the base 1 and placed vertically, a worktable 3 mounted on the upper end of the compression spring 2, and a vibration motor 4 mounted on the lower surface of the worktable 3. The top end of the compression spring 2 is fixedly connected to the bottom surface of the worktable 3 (e.g., by welding or by bolts and a pressure plate), and the bottom end is fixedly connected to the top surface of the base 1 (e.g., by welding or by bolts and a pressure plate). This invention also includes a rotating bottle 5. The housing of the vibration motor 4 is fixedly mounted on the lower surface of the worktable 3 by bolts; when the vibration motor 4 is running, it drives the worktable 3 and the rotating bottle 5 placed on the worktable 3 to vibrate synchronously to shake the mixture (a mixture of nicergoline impurity E raw material and organic solvent) in the rotating bottle 5.
[0039] Reference Figures 1-3 The workbench 3 includes a base plate 31, a top plate 32 placed above the base plate 31, and a vertical support plate 33. The base plate 31 and the top plate 32 are horizontally positioned and parallel to each other. The support plate 33 is placed between the base plate 31 and the top plate 32. The top end of the support plate 33 is vertically and fixedly connected to the top plate 32 (e.g., by bolts or by welding), and the bottom end is vertically and fixedly connected to the base plate 31 (e.g., by bolts or by welding). The support plate 33 provides structural support for the top plate 32.
[0040] Reference Figures 2-3The top plate 32 is provided with a circular hole 321, and an electrically driven heating sheet 322 is arranged in the circular hole 321. The heating sheet 322 is in a hemispherical shell structure and is open upward. The spherical bottom surface of the rotary bottle 5 can be placed in the heating sheet 322 and is attached to the inner wall of the heating sheet 322 (directly or indirectly). The inner wall of the heating sheet 322 is provided with a flexible graphite layer, a heat-conducting rubber layer or a heat-conducting silica gel layer, so as to avoid the problem of a gap between the heating sheet 322 and the rotary bottle 5 and reduce the heat conduction efficiency.
[0041] With reference to Figures 2-3 The outer edge of the heating sheet 322 is fixedly connected with the top plate 32 (for example, by bolt connection).
[0042] With reference to Figure 2 The top plate 32 is provided with a plug-in hole 323, and a clamping arm 324 is rotatably connected in the plug-in hole 323. The clamping arm 324 can press and connect the rotary bottle 5 which is in a spherical shape at the middle and lower parts and is placed in the heating sheet 322. The upper end of the rotary bottle 5 is in a straight cylinder shape, and the middle and lower parts are in a spherical shape. The rotary bottle 5 is a glass bottle as a whole. Figure 3 When the clamping arm 324 is rotated to an open state, the user can put the rotary bottle 5 into the heating sheet 322 or take it out of the heating sheet 322.
[0043] With reference to Figure 4 And Figure 5 The clamping arm 324 includes an attaching part 3241, a plug-in part 3242 and a counterweight part 3243. The attaching part 3241 is in an arc plate shape. The plug-in part 3242 is in a 7-shaped structure and is plugged into the plug-in hole 323. The top end of the plug-in part 3242 is fixedly connected with the bottom end of the attaching part 3241 (for example, by bolt connection or by integral connection). The bottom end of the plug-in part 3242 is fixedly connected with the counterweight part 3243 (for example, by bolt connection). The plug-in part 3242 and the counterweight part 3243 are arranged in a z-shaped structure, so as to provide a rotating space for the attaching part 3241 and the counterweight part 3243.
[0044] With reference to Figure 2 And Figure 5 The attaching part 3241 can be adapted to the upper part of the spherical outer surface of the rotary bottle 5, so as to exert a limiting force on the rotary bottle 5 and avoid the rotary bottle 5 from being separated from the heating sheet 322 during the vibration of the workbench 3, thereby improving the reliability of the utility model.
[0045] With reference to Figure 4 And Figure 5The insertion part 3242 includes a first rod 32421 and a second rod 32422 fixedly connected in a figure-7 shape; the first rod 32421 is connected to the fitting part 3241, and the second rod 32422 is connected to the counterweight part 3243; the first rod 32421 and the second rod 32422 are integrally fixedly connected. A rotating shaft is inserted into the middle of the second rod 32422, and both ends of the rotating shaft are respectively connected to the inner sidewall of the insertion hole 323. The two inner sidewalls of the insertion hole 323 are respectively provided with insertion holes, and the two ends of the rotating shaft are respectively inserted into the two insertion holes with clearance fit, thereby ensuring that the arm 324 can rotate smoothly.
[0046] Reference Figure 2 and Figure 6 An electromagnet 331 is provided on the side wall of the support plate 33. The electromagnet 331 is fixedly installed on the front side wall of the support plate 33 by bolts. When the electromagnet 331 is energized, it can attract the counterweight 3243, thereby driving the arm 324 to rotate, so that the contact part 3241 presses against and limits the rotating bottle 5, thus preventing the rotating bottle 5 from falling out of the heating element 322. (Refer to...) Figure 3 When the electromagnet 331 is de-energized, the counterweight drives the entire clamping arm 324 to rotate under its own weight, thereby opening the clamping arm 324. Compared to the worm gear mechanism used in traditional technologies, this invention utilizes electromagnetic and gravity principles to drive the clamping arm 324, resulting in a faster engagement / disengagement speed and a smaller size (worm gear mechanisms require independent motors or transmission structures). This allows for the creation of more circular holes 321 and the installation of more heating elements 322 on the worktable 3, thereby enabling the placement of more rotating bottles 5 and improving the shaking efficiency.
[0047] Reference Figure 2 and Figure 5 The arm 324 also includes an extension 3244, which is fixedly disposed at the end of the counterweight 3243 away from the insertion part 3242. The extension 3244 and the counterweight 3243 are fixedly connected in a figure-7 shape (e.g., by an integral fixed connection or by bolts). The extension 3244 and the counterweight 3243 can be attracted by the electromagnet 331 at the same time, thereby increasing the driving force. The side wall of the extension 3244 and the end face of the counterweight 3243 are flush, so in the adsorption state, the side wall of the extension 3244 and the end face of the counterweight 3243 are both in contact with the electromagnet 331, thereby increasing the contact area, improving the adsorption stability, and further ensuring that the contact part 3241 can stably press the rotating bottle 5 without detaching or bouncing.
[0048] Reference Figure 5 The insertion part 3242 and the extension part 3244 are respectively located on both sides of the counterweight part 3243.
[0049] Reference Figure 2 and Figure 6The side wall of the back support plate 33 opposite to the electromagnet 331 is provided with a back support rod 332. The side wall of the back support rod 332 is attached to and fixedly connected with the side wall of the back support plate 33 (for example, by bolted connection or by welding). The top end of the back support rod 332 is fixedly connected with the top plate 32 (for example, by bolted connection or by welding), and the bottom end is fixedly connected with the bottom plate 31 (for example, by bolted connection or by welding). The back support rod 332 is used to assist the back support plate 33 to exert a supporting force on the top plate 32, thereby avoiding the problem of bending of the back support plate 33 under pressure, so that the workbench 3 can carry more rotary bottles 5 and the mixture in the rotary bottles 5.
[0050] The holding arms 324 are provided with a plurality of holding arms 324 arranged around the outer periphery of the heating sheet 322. The plurality of holding arms 324 are arranged in an equidistant and equiangular circumferential array around the circular hole 321. The plurality of abutting portions 3241 can be circumferentially pressed onto the outer surface of the rotary bottle 5 to improve the stability of the limiting.
[0051] Referring to Figure 5 , the weight portion 3243 and the extension portion 3244 are made of ferrous metal material, for example, 45 steel. The abutting portion 3241 and the insertion portion 3242 are made of hollow lightweight plastic material, for example, polyethylene. The center of gravity of the holding arm 324 is located in the middle and lower part, so that the holding arm 324 can be smoothly opened.
[0052] Referring to Figure 2 and Figure 3 , the heating sheet 322 is provided below with a support seat 311 fixedly connected with the heating sheet 322 and the bottom plate 31 on the top and bottom surfaces respectively. The top surface of the support seat 311 is fixedly connected with the heating sheet 322 by bolts, and the bottom surface of the support seat 311 is fixedly connected with the bottom plate 31 by bolts. The support seat 311 is made of ceramic material and has excellent heat resistance.
[0053] Referring to Figure 5 , the inner wall of the abutting portion 3241 is provided with an elastic friction layer 32411 made of elastic rubber material. The elastic friction layer 32411 is fixedly connected with the abutting portion 3241 by adhesion or by bolts. When the abutting portion 3241 is pressed against the rotary bottle 5, the elastic friction layer 32411 comes into contact with the rotary bottle 5, thereby increasing the friction between the holding arm 324 and the rotary bottle 5, avoiding the occurrence of gaps between the holding arm 324 and the rotary bottle 5, and further avoiding damage caused by the rotary bottle 5 hitting the holding arm 324.
[0054] This utility model also includes an electrical cabinet, which is fixedly installed on the bottom surface of the workbench 3 by bolts; the heating element 322, the vibration motor 4 and the electromagnet 331 are respectively connected to the electrical cabinet by wires and signal lines; the electrical cabinet is connected to the external power supply and the external computer by wires and signal lines, respectively. The computer controls the start and stop of the heating element 322, the vibration motor 4 and the electromagnet 331 in this utility model through the electrical cabinet, thereby controlling the working state of this utility model.
[0055] This utility model has a simple structure and reliable function. The workbench 3 includes a top plate 32. A heating element 322 is installed in the round hole 321 of the top plate 32. The heating element 322 has a hemispherical shell structure, which is used to accommodate the middle and lower spherical part of the rotating bottle 5, so as to realize the stable placement of the rotating bottle 5.
[0056] The arm 324 can rotate to achieve fastening and opening; in the fastened state, the fitting part 3241 presses the rotating bottle 5, thereby preventing the rotating bottle 5 from jumping out of the heating plate 322 when the worktable 3 vibrates, thus improving the stability of the rotating bottle 5; in the open state, the user can easily place the rotating bottle 5 into the heating plate 322 or take it out of the heating plate 322.
[0057] In the description of this utility model, it should be noted that the terms "upper", "lower", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.
[0058] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," and "connect" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or a connection through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.
[0059] In conclusion, for those skilled in the art, any changes, modifications, substitutions, or variations made to this utility model based on its guidance, without departing from its principles and spirit, shall still fall within the protection scope of this utility model.
Claims
1. A dissolving apparatus for purifying nicergoline impurity E, characterized in that: Includes a base (1), a compression spring (2) mounted on the upper surface of the base (1) and standing upright, a worktable (3) mounted on the upper end of the compression spring (2), and a vibration motor (4) mounted on the lower surface of the worktable (3); The workbench (3) includes a base plate (31), a top plate (32) placed above the base plate (31), and an upright support plate (33); the upright support plate (33) is placed between the base plate (31) and the top plate (32); the top end of the upright support plate (33) is vertically fixed to the top plate (32), and the bottom end is vertically fixed to the base plate (31); The top plate (32) is provided with a circular hole (321), and an electrically driven heating element (322) is provided inside the circular hole (321). The heating element (322) has a hemispherical shell structure, and the outer edge of the heating element (322) is fixedly connected to the top plate (32). The top plate (32) is provided with a plug hole (323), and a clamping arm (324) is rotatably connected in the plug hole (323); the top of the clamping arm (324) can press and limit the rotating bottle (5) which is spherical in the lower part and placed in the heating plate (322).
2. The dissolving apparatus for purifying nicergoline impurity E according to claim 1, characterized in that: The arm (324) includes a fitting part (3241), a plug-in part (3242), and a counterweight part (3243); the fitting part (3241) is arc-shaped and can fit and fit the spherical outer surface of the rotating bottle (5); the plug-in part (3242) is 7-shaped and is inserted into the plug-in hole (323); the top end of the plug-in part (3242) is fixedly connected to the bottom end of the fitting part (3241), and the bottom end of the plug-in part (3242) is fixedly connected to the counterweight part (3243); the plug-in part (3242) and the counterweight part (3243) are arranged in a Z-shape.
3. The dissolving apparatus for purifying nicergoline impurity E according to claim 2, characterized in that: The insertion part (3242) includes a first rod (32421) and a second rod (32422) fixedly connected in a figure-7 shape; the first rod (32421) is connected to the fitting part (3241), and the second rod (32422) is connected to the counterweight part (3243); A rotating shaft is inserted into the middle of the second rod (32422), and the two ends of the rotating shaft are respectively connected to the inner sidewall of the insertion hole (323).
4. The dissolving apparatus for purifying nicergoline impurity E according to claim 3, characterized in that: The arm (324) also includes an extension (3244), which is fixedly disposed at the end of the counterweight (3243) away from the plug (3242); the extension (3244) and the counterweight (3243) are fixedly connected in a figure-7 shape.
5. The dissolving apparatus for purifying nicergoline impurity E according to claim 4, characterized in that: The plug portion (3242) and the extension portion (3244) are respectively disposed on both sides of the counterweight portion (3243).
6. The dissolving apparatus for purifying nicergoline impurity E according to claim 5, characterized in that: The side wall of the support plate (33) is provided with an electromagnet (331); the electromagnet (331) can attract the counterweight (3243) to drive the arm (324) to rotate, so that the fitting part (3241) presses against and limits the rotating bottle (5).
7. The dissolving apparatus for purifying nicergoline impurity E according to claim 6, characterized in that: The support plate (33) has a back support rod (332) on its side wall facing away from the electromagnet (331); the side wall of the back support rod (332) is attached to and fixedly connected to the side wall of the support plate (33), the top end of the back support rod (332) is fixedly connected to the top plate (32), and the bottom end is fixedly connected to the bottom plate (31).
8. The dissolving apparatus for purifying nicergoline impurity E according to claim 7, characterized in that: The arm (324) is provided in a plurality of units and is disposed on the outer periphery of the heating plate (322); the plurality of arms (324) are arranged in a circular array with equal spacing and equal angles around the circular hole (321).
9. The dissolving apparatus for purifying nicergoline impurity E according to claim 8, characterized in that: The counterweight (3243) and the extension (3244) are made of iron-containing metal materials.
10. The dissolving apparatus for purifying nicergoline impurity E according to any one of claims 1-9, characterized in that: A support base (311) is provided below the heating element (322), and the top and bottom surfaces of the support base (311) are fixedly connected to the heating element (322) and the base plate (31) respectively.