Composition for antioxidant activity, hair root improvement and hair loss prevention and alleviation, comprising viola papilionacea extract as active ingredient, and food and external use preparation comprising same

Abstract

The present invention relates to: a composition for antioxidant activity, hair root improvement and hair loss prevention and alleviation, comprising a Viola papilionacea extract as an active ingredient; and a food and an external use preparation comprising same. According to one embodiment, the objective of the present invention is to provide a composition for improving hair roots and preventing or alleviating hair loss and also exhibiting excellent antioxidant activity by comprising a Viola papilionacea extract as an active ingredient. In particular, the composition has no side effects such as cytotoxicity and skin irritation, and thus can achieve effects according to the aforementioned functionality while being used for a long period of time.

Description

Composition for antioxidant, hair root improvement, and hair loss prevention and improvement containing extract of Jongjina plant as an active ingredient, and food and external preparation containing the same

[0001] The present invention relates to a composition for antioxidant activity, hair root improvement, and hair loss prevention and improvement, comprising an extract of the plant, as an active ingredient, and to a food product and an external preparation comprising the same. More specifically, the present invention provides a composition comprising an extract of the plant, as an active ingredient, which exhibits excellent antioxidant activity, and improves hair root activity and prevents or improves hair loss. In particular, the composition is free from side effects such as cytotoxicity and skin irritation, and thus can be used for a long period of time to achieve the above-described effects. Furthermore, the present invention provides a food product or a personal care product comprising the composition, or a variety of other formulations, so that products can be produced in various forms to achieve the above-described functions.

[0002] Pollutants such as yellow dust, pollen, and fine dust that cause various eye diseases and bronchial diseases due to environmental pollution also affect the scalp. When dust accumulates on the scalp and causes trouble, the scalp becomes itchy and hot, causing inconvenience in daily life.

[0003] Scalp problems are caused by the accumulation of sebum and waste products. In fact, men have more active sebum secretion than women due to hormonal influences, so they are more prone to developing blisters and dandruff on their scalps. In addition, if they use a lot of hair styling products such as gels or sprays, residue can remain on the scalp and cause problems. Excessive drinking, smoking, high-calorie diets, and stress can also cause scalp problems.

[0004] In particular, when you are stressed, the body's immune response occurs, making inflammation worse. Scalp troubles with severe inflammation can block pores. At this time, blood circulation to hair follicle cells is disrupted, nutrients are not supplied properly, and if the condition persists for a long time, it eventually leads to hair loss.

[0005] In addition, in modern society that values ​​beauty, many people of all ages and genders use hair dyes and perms to satisfy their desire to express their individuality. In the case of sensitive scalps, chemical treatments such as dyeing and perms cause irritation and inflammation such as itchiness and stinging of the scalp, and these irritation and inflammation lead to environmental hair loss.

[0006] More specifically, the human body has approximately 100,000 to 150,000 hairs, formed from "hair follicles." Each hair follicle contains a papilla, a region lined with tiny blood vessels that supply the nutrients necessary for hair growth. Above and next to the papilla are sebaceous glands, which supply oils that give the hair its luster.

[0007] Each hair has a unique cycle, progressing through the growth (anagen), regression (catagen), and resting (telogen) phases before growing and falling out. This cycle repeats itself over a period of three to six years, with an average of 50 to 100 hairs normally shed daily.

[0008] Generally, hair loss refers to an abnormal increase in the number of hairs that fall out due to a shortening of the proportion of hairs in the growth phase and an increase in hairs in the catagen or resting phase during this cycle.

[0009] The causes of hair loss are discussed as follows: excessive male hormone action, excessive sebum secretion, poor blood circulation, decreased scalp function due to peroxide, bacteria, genetic factors, aging, stress, etc.

[0010] Specifically, testosterone, a type of male hormone, is activated into dihydrotestoserone (DHT) by an enzyme called 5α-reductase. This DHT binds to a specific receptor and converts it into a protein that causes hair loss.

[0011] Hair loss occurs by inducing sebum production. This same mechanism can also cause excessive sebum production, which can lead to acne or seborrheic dermatitis, leading to hair loss accompanied by inflammation of the scalp.

[0012] However, in the case of preparations such as minoxidil or tricosaccharide, which are known to have the effect of preventing hair loss and promoting hair growth, there are issues with the absence of clear efficacy, safety in the human body, and side effects such as skin irritation, so there is an urgent need to develop a composition that ensures safety and efficacy.

[0013] In relation to the prior art literature, Patent No. 10-1438392 discloses a means for obtaining a shampoo composition for promoting hair growth / preventing hair loss, comprising the first step of making a mixed material by grinding Seokchangpo 35%, kelp 15%, Hyeonggae 5%, loquat leaf 4%, Gobon 4%, licorice 3%, Wonji 5%, peppermint 5%, whole choy 5%, Eui-in 5%, Jukyeo 3%, white wine 4%, black beans 1%, black sesame 1%, honey 1%, green tea leaves 2%, and persimmon leaves into powder in a ratio of 35%, 5%, 5%, 5%, 5%, 3%, 4%, 4%, 1%, 1%, 2%, 2%, and 2%; the second step of making a mixed solution by soaking in alcohol of 95% purity corresponding to 5 times the amount of the mixed material, stirring evenly 7-10 times for 20-24 hours, and maturing at low temperature; A technology is presented to promote hair growth and prevent hair loss through a shampoo composition provided, including a third step of producing a completed shampoo by mixing a mixed solution with alkaline water dissolved in it at a 1:1 ratio.

[0014] Patent registration No. 10-1438392 discloses a means for obtaining a shampoo composition for promoting hair growth / preventing hair loss, comprising the first step of making a mixed material by grinding together 35% Seokchangpo, 15% Kelp, 5% Hyeonggae, 4% Loquat leaf, 4% Gobon, 3% Glycyrrhiza uralensis, 5% Wonji, 5% Peppermint, 5% Tongcho, 5% Eui-in, 3% Jukyeo, 4% White wine, 1% Black bean, 1% Black sesame, 1% Honey, 2% Green tea leaf, and 2% Persimmon leaf; the second step of making a mixed solution by soaking in 95% pure alcohol equivalent to 5 times the amount of the mixed material, stirring evenly 7-10 times for 20-24 hours, and maturing at low temperature; A technology is presented to promote hair growth and prevent hair loss through a shampoo composition provided, including a third step of producing a completed shampoo by mixing a mixed solution with alkaline water dissolved in it at a 1:1 ratio.

[0015] In addition to the above technology, conventional shampoo compositions have attempted to use a combination of multiple ingredients, such as a blood circulation promoter that expands capillaries, a blood circulation promoter through local stimulation, a hair root function revitalizer, an androgen inhibitor, an antiseptic, a keratolytic, a bactericidal anti-inflammatory, and amino acids and vitamins to supply nutrients to hair roots and revive enzyme activity. However, the hair growth effect is not yet excellent enough to meet consumer demands, and there are problems with stability, so improvements have been requested.

[0016] Furthermore, there is an urgent need for the development of a composition that has scalp stimulation and antioxidant effects as well as the efficacy of preventing hair loss and promoting hair growth due to its use with various shampoos such as hair dyes and perms.

[0017] [Prior Art Literature]

[0018] [Patent Document]

[0019] (Patent Document 1) KR 10-1438392 B1

[0020] (Patent Document 2) KR 10-2005777 B1

[0021] The purpose of the present invention is to provide an antioxidant composition based on natural products.

[0022] The purpose of the present invention is to provide a composition based on natural substances that exhibits scalp improvement, hair loss prevention, and improvement effects.

[0023] The purpose of the present invention is to provide a composition that can be taken or used for a long period of time without causing side effects.

[0024] Another object of the present invention is to provide various formulations of food, detergent or external preparation containing the above composition and capable of achieving the functional effect of the above composition.

[0025] In order to achieve the above purpose, a composition for preventing and improving hair loss according to one embodiment of the present invention includes an extract of the plant.

[0026] The above composition for preventing and improving hair loss may further include a first extract selected from the group consisting of laver extract, seaweed extract, kelp extract, seaweed extract, laver extract, and mixtures thereof.

[0027] The above composition for preventing and improving hair loss may further include a second extract selected from the group consisting of lavender extract, mint extract, peppermint extract, basil extract, thyme extract, and mixtures thereof.

[0028] The above composition for preventing and improving hair loss may further contain soybeans.

[0029] According to another embodiment of the present invention, an antioxidant composition comprises the extract or a composition containing a mixture of the extracts.

[0030] According to another embodiment of the present invention, a food product comprises the composition.

[0031] A functional food according to another embodiment of the present invention comprises the composition.

[0032] According to another embodiment of the present invention, a personal care product comprises the composition.

[0033]

[0034] Hereinafter, the present invention will be described in more detail.

[0035] A composition for preventing and improving hair loss according to one embodiment of the present invention comprises an extract of the plant.

[0036] "Hair loss" refers to a phenomenon in which hair falls out from the scalp or a condition in which hair becomes thicker or thinner. "Hair loss prevention" refers to preventing or suppressing the hair loss phenomenon described above, and "hair loss improvement" refers to improving the hair loss phenomenon described above compared to before. In addition, "hair loss prevention and improvement" as referred to in the present invention is defined as including the function of improving hair roots and promoting hair growth. "Promoting hair growth" refers to not only promoting the creation of new hair but also helping existing hair grow healthily.

[0037] Typically, "hair growth" occurs during the anagen phase, facilitated by induction from the telogen phase to the growth phase and delay from the growth phase to the catagen phase. The hair cycle can be divided into three main phases: anagen, catagen, and telogen. During the anagen phase, hair formation occurs as the hair follicle grows deep into the skin, accompanied by rapid cell proliferation. The next phase, catagen, is a transitional phase marked by a marked cessation of cell division, during which the hair follicle gradually regresses and hair growth ceases. During the telogen phase, the catagen follicle contains a germ, densely packed with dermal papilla cells. The initiation of a new anagen phase from the telogen phase is induced by rapid cell proliferation in the germ, expansion of the dermal papilla, and synthesis of basement membrane elements.

[0038] Therefore, it is necessary to prevent hair loss, i.e., prevent hair loss, or induce hair regrowth, i.e., promote hair growth, by promoting or extending the growth phase. The composition according to one embodiment of the present invention includes at least one of the effects of preventing existing hair from falling out, improving existing hair by thickening it, and generating new hair. In addition, when the extract of the paper tree according to the present invention is included, hair loss can be prevented through antioxidant activity, and at the same time, hair papilla cells can be activated to induce hair growth and increase its density.

[0039] Viola papilionacea, Meadow, Hooded blue violet, is a perennial herb in the Violaceae family, a naturalized plant introduced from the United States. Its leaves arise in clusters from the base, with petioles longer than the blade. The leaves are bell-shaped, heart-shaped, slightly acuminate at the tip, and have serrated margins. The flowers are a mixture of purple, white, and yellow-green, and the fruits are oblong, green or blackish-purple, and the seeds are blackish-brown.

[0040] The term 'extract' used herein has the meaning commonly used in the art as a crude extract as described above, but in a broad sense, it also includes fractions obtained by further fractionation of the extract. That is, the extract includes not only those obtained using the above-described extraction solvent, but also those obtained by additionally applying a purification process thereto. For example, fractions obtained by passing the extract through an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatographies (designed for separation according to size, charge, hydrophobicity, or affinity), and other additionally performed fractions obtained through various purification methods are also included in the extract of the present invention.

[0041] The solvent of the extract referred to in the present invention may be any one selected from the group consisting of purified water, alcohols having 1 to 10 carbon atoms, and mixtures thereof.

[0042] The above composition for preventing and improving hair loss may further include a first extract selected from a group consisting of laver extract, seaweed extract, kelp extract, seaweed extract, laver extract, and mixtures thereof.

[0043] In the case of the above mixing, the yield of the effective ingredient that increases the activity of breast papilla cells along with antioxidant activity increases, and thus a synergistic effect can be achieved.

[0044] Preferably, the first extract may be a kelp extract. The kelp extract may have the most excellent hair loss prevention and improvement effects.

[0045] The above composition for preventing and improving hair loss may further include a second extract selected from the group consisting of lavender extract, mint extract, peppermint extract, basil extract, thyme extract, and mixtures thereof.

[0046] In the case of the second extract above, the interaction of the active ingredients mixed in each extract exhibits strong antioxidant activity, and the hair loss prevention and improvement effect can be excellent.

[0047] The above composition for preventing and improving hair loss may further contain soybeans.

[0048] The above-mentioned Glycine soja is an annual vine of the legume family, order Rosales, and growing in fields. It has brown hairs all over, and the stem is thin and long, and it twines around other objects. It can reach 2 m in length. The leaves are opposite, have long petioles, and are trifoliate. The leaflets are ovate-elliptic or lanceolate, 3 to 8 cm long and 8 to 25 mm wide, and have no teeth on the margins. The stipules are broadly lanceolate, 2 to 3 mm long, and have leaf veins. The small stipules are lanceolate, have pointed tips, are 1.5 to 2 mm long, and have three veins.

[0049] The flowers bloom in July or August, and the raceme is 2 to 5 cm long. The calyx is bell-shaped, hairy, and divided into five lobes. The corolla is butterfly-shaped. There are ten stamens, each divided into two lobes. The fruit is 2 to 3 cm in size, hairy, and resembles a bean pod. The seeds are oval or kidney-shaped and slightly flat. The seeds can be used like beans. It is distributed in Jeju Island, South Jeolla Province, South Gyeongsang Province, Gyeonggi Province, Hwanghae Province, North Pyongan Province, China, Japan, and the Amur Region.

[0050] If the above-mentioned soybean extract is included, the effect of preventing and improving hair loss can be enhanced by increasing the activity of antioxidant and hair papilla cells and improving hair roots.

[0051] Preferably, the composition comprises a kelp extract, and may comprise 150 to 250 parts by weight of a kelp extract, 150 to 250 parts by weight of a lavender extract, and 10 to 50 parts by weight of a soybean plant, based on 100 parts by weight of the kelp extract.

[0052] The above-mentioned mixed composition achieves superior hair loss prevention and improvement effects through the synergistic interaction of the active ingredients contained in each extract. Consequently, superior results can be achieved with a lower dosage, and long-term use is free of side effects.

[0053] More preferably, the composition may include an extract of a plant, and may include 150 to 250 parts by weight of a kelp extract, 150 to 250 parts by weight of a lavender extract, 10 to 50 parts by weight of a soybean sprout, 1 to 10 parts by weight of a mountain chrysanthemum extract, and 1 to 10 parts by weight of a baby umbrella plant, with respect to 100 parts by weight of the extract of a plant.

[0054] Saussurea neoserrata (San-gol-chwi) is a perennial herb of the Asteraceae family in the Campanulate order of dicotyledons. It grows deep in the mountains. It grows 50 to 110 cm tall. The stem is erect and sometimes branches upward. The leaf bases flow down the stem, forming the stem wings. The leaves at the base and those at the base fall when the flower blooms. The leaves on the stem are opposite, lanceolate or ovate-lanceolate, and 12 to 15 cm long. The apex is acute and the base tapers. The leaves become smaller toward the top, and the back has curly hairs and sharp serrations. The purple flowers bloom in August or September. The flower heads are borne in corymbs at the ends of branches and the main stem, and the flowers are 8 to 10 mm in diameter. The involucre is tubular, 8 to 9 mm long and 4 to 5 mm in diameter. The spores are arranged in four rows, with purple margins and cobweb-like white hairs. The fruit is an achene, about 5 mm long, with black-brown stripes. The crown is brown and has two rows of hairs. Young shoots are edible. It is a species endemic to Korea and is distributed in the northern region.

[0055] Syneilesis aconitifolia (Bunge) Maxim is a perennial plant in the Asteraceae family that grows to a height of 70 to 120 cm. Its roots are short and grow sideways, and its main stem is purple and unbranched, with two leaves. The first leaf is round and 20 to 30 cm in diameter, divided into lanceolate lobes with 7 to 9 lobes arranged in 2 or 3 groups. The second leaf is slightly smaller, 12 to 24 cm in diameter, its lobes are 4 to 5 cm wide, and its petioles are 2 to 6 cm long. The leaves are round and 20 to 30 cm in diameter, divided into lanceolate lobes, and the flowers bloom from July to August.

[0056] If the above-mentioned extracts of San-gol-chwi and Aegi-um-sang extract are further included in the above range, additional synergistic activity can be achieved to achieve a more advantageous effect in preventing and improving hair loss.

[0057] According to another embodiment of the present invention, an antioxidant composition comprises the extract or a composition containing a mixture of the extracts.

[0058] According to another embodiment of the present invention, a food product comprises the composition.

[0059] The above foods include general foods, processed foods, health functional foods, and functional foods, and examples of the above foods can be applied in the form of beverages, tea, tablets, processed meat foods, snacks, instant foods, etc.

[0060] For example, processed foods include snacks, beverages, alcoholic beverages, fermented foods, canned foods, dairy products, processed meat products, noodles, etc. Snacks include biscuits, pies, cakes, bread, candy, jellies, gum, cereals, etc. Beverages include drinking water, carbonated beverages, functional sports drinks, functional sports drinks, juices (e.g., apple, pear, grape, aloe, tangerine, peach, carrot, tomato juice, etc.), sikhye, etc. Alcoholic beverages include cheongju, whiskey, soju, beer, western liquor, fruit wine, etc. Fermented foods include soy sauce, doenjang, red pepper paste, etc. Canned foods include canned seafood (e.g., canned tuna, mackerel, saury, conch, etc.), canned livestock products (e.g., canned beef, pork, chicken, turkey, etc.), and canned agricultural products (e.g., canned corn, peaches, pineapple). Dairy products include cheese, butter, yogurt, etc. Processed meat products include pork cutlets, beef cutlets, chicken cutlets, sausages, sweet and sour pork, nuggets, and savory dishes. They also include noodles, such as sealed fresh noodles. In addition, the composition can be used in retort foods, soups, and the like, but is not limited thereto.

[0061] A functional food according to another embodiment of the present invention comprises the composition.

[0062] The functional food described above includes health functional foods in addition to general foods. In addition, there are no special limitations on the type and formulation of the health functional foods described above. The functional food according to the present invention may include ingredients commonly added during food manufacturing. For example, it includes proteins, carbohydrates, fats, nutrients, and seasonings. For example, when manufactured as a drink, it may include natural carbohydrates or flavoring agents as additional ingredients in addition to the active ingredient. The natural carbohydrates are preferably monosaccharides (e.g., glucose, fructose, etc.), disaccharides (e.g., maltose, sucrose, etc.), oligosaccharides, polysaccharides (e.g., dextrin, cyclodextrin, etc.), or sugar alcohols (e.g., xylitol, sorbitol, erythritol, etc.). The flavoring agent may be a natural flavoring agent (e.g., thaumatin, stevia extract, etc.) or a synthetic flavoring agent (e.g., saccharin, aspartame, etc.).

[0063] In addition, in addition to the functional food or health functional food composition according to the present invention containing the composition as an active ingredient, it may further contain various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloid thickeners, pH regulators, stabilizers, preservatives, glycerin, alcohol, carbonating agents used in carbonated beverages, etc.

[0064] According to another embodiment of the present invention, a personal care product comprises the composition.

[0065] In the present invention, "personal care products" include, but are not limited to, cosmetics, hair care products, toiletries, cosmeceuticals, beauty aids, insect repellents, personal hygiene and cleansing products applied to the body, including the skin, hair, scalp, and nails of humans and animals, and can be applied to all personal care compositions containing fragrances.

[0066] Specifically, deodorants, antiperspirants, sprays, sticks and roll-ons, shaving products, skin lotions, moisturizers, toners, bath products, cleansers, shampoos, conditioners, combination shampoos / conditioners, mousses, styling gels, hairsprays, hair dyes, hair colors, hair bleaches, waving agents, hair straighteners, nail polishes, nail polish removers, nail creams and lotions, keratin softeners, sunscreens, insect repellents, anti-aging agents, lipsticks, foundations, face powders, eyeliners, eye shadows, blushes, makeup, mascaras, moisturizing preparations, body and hand preparations, skincare preparations, face and neck preparations, tonics, dressings, hair grooming aids, aerosol fixatives, fragrance preparations, aftershaves, makeup preparations, soft focus products, night and day skincare preparations, Non-coloring hair preparations, tanning preparations, synthetic and non-synthetic soap bars, hand liquids, nose strips, non-woven articles for personal care, baby lotions, baby baths and shampoos, baby conditioners, shaving preparations, cue comb slices, skin pads, makeup removers, facial cleansers, cold creams, sunscreens, mousses, spritzes, paste masks and muds, face masks, colognes and toners, hair cuticle coats, shower gels, face and body washes, personal care rinse-offs, gels, foam baths, scrubbing cleansers, astringents, nail conditioners, eye shadow sticks, face or eye powders, lip balms, lip glosses, hair care pump sprays and other non-aerosol sprays, hair frizz control gels, hair leave-in conditioners, hair pomades, hair detangling agents, hair fixatives, hair Bleach, skin lotions, pre-shave and pre-electric shaves, anhydrous creams and lotions, oily / water-based, water-based, multiple macro and micro emulsions, water-resistant creams and lotions, acne-prone skin preparations, mouthwashes, massage oils, toothpastes, clear gels and sticks, ointment bases, topical wound healing agents, aerosol talc, barrier sprays, vitamin and anti-aging preparations, herbal extract preparations,Including but not limited to bath salts, bath and body milks, hair styling aids, hair-, eye-, nail- and skin-softening products, controlled-release personal care agents, hair conditioning mists, skin care moisturizing mists, skin wipes, pore skin wipes, pore cleansers, blemish reducers, skin exfoliators, exfoliators, skin towelettes and cloths, hair removal agents, personal care lubricants and nail color preparations.

[0067] The personal care product of the present invention, such as a cosmetic, may be prepared in a formulation selected from the group consisting of a solution, an external ointment, a cream, a foam, a nourishing toner, an emollient toner, a pack, an emollient, a milky lotion, a makeup base, an essence, a soap, a liquid cleanser, a bath additive, a sunscreen cream, a sun oil, a suspension, an emulsion, a paste, a gel, a lotion, a powder, a soap, a surfactant-containing cleansing, an oil, a powder foundation, an emulsion foundation, a wax foundation, a patch, and a spray, but is not limited thereto.

[0068] The cosmetic of the present invention may additionally include one or more cosmetically acceptable carriers that are incorporated into general skin cosmetics, and may appropriately incorporate conventional ingredients such as oil, water, surfactants, moisturizers, lower alcohols, thickeners, chelating agents, pigments, preservatives, fragrances, etc., but is not limited thereto. The cosmetically acceptable carriers included in the cosmetic of the present invention vary depending on the formulation.

[0069] When the formulation of the present invention is an ointment, paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide or a mixture thereof may be used as a carrier component.

[0070] When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder or a mixture thereof may be used as a carrier component, and particularly in the case of a spray, a propellant such as chlorofluorohydrocarbon, propane / butane or dimethyl ether may be additionally included.

[0071] When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizer or an emulsifier is used as a carrier component, and for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil can be used, and in particular, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan can be used.

[0072] When the formulation of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth, etc. can be used as a carrier component.

[0073] When the formulation of the present invention is soap, alkali metal salts of fatty acids, fatty acid hemiester salts, fatty acid protein hydrolysates, isethionates, lanolin derivatives, fatty alcohols, vegetable oils, glycerol, sugars, etc. can be used as carrier components.

[0074] The cosmetics of the present invention may vary in the content of the fragrance composition depending on the formulation. For example, wash-off type cosmetics such as makeup removers and cleansers, in which the active ingredient remains on the skin for a short period of time, may contain a relatively high concentration. On the other hand, leave-on type cosmetics such as toners, emulsions, creams, and essences, in which the active ingredient remains on the skin for a long period of time, may contain a lower concentration than wash-off type cosmetics.

[0075] Personal care products of the present invention, such as hair care products, include, but are not limited to, shampoos (including combination shampoos such as two-in-one conditioning shampoos), hair conditioners, shampoo rinses, hair dyes, setting, styling and style maintenance agents (including setting aids such as gels and sprays, and grooming aids such as pomades, conditioners, perm solutions, relaxers), and hair smoothing products.

[0076] The above hair care product may include, but is not limited to, the fragrance composition of the present invention and at least one selected from the group consisting of a cationic surfactant, an amphoteric surfactant, a nonionic surfactant, and a cationic polymer. The cationic surfactant used in the hair care product may include, but is not limited to, at least one selected from the group consisting of cetrimonium chloride, stearamidopropyldimethylamine, dicetyldimethylammonium chloride, and ester quattro.

[0077] The amphoteric surfactant used in the hair care product may be at least one selected from the group consisting of cocamidopropyl betaine, cocoamphocarboxyglycinate, and cocoamphocarboxypropionate, but is not limited thereto.

[0078] The nonionic surfactant used in the hair care product may be at least one selected from the group consisting of lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid monoethanolamide, lauryl dimethylamine oxide, and palm oil alkyl dimethylamine oxide, but is not limited thereto. The cationic polymer used in the hair care product may be at least one selected from the group consisting of natural cationic polymers such as guar hydroxypropyltrimonium chloride, hydroxypropylguar hydroxypropyltrimonium chloride, and quaternary hydroxyethylcellulose; and the group consisting of synthetic cationic polymers such as dimethyl diallyl ammonium chloride polymer, acrylamidomethyl diallyl ammonium chloride copolymer, and polyvinylpyrrolidone dimethylaminoethyl methacrylate copolymer, but is not limited thereto. The hair dye may be a hair dye comprising the fragrance composition of the present invention and a precursor and a coupler, but is not limited thereto.

[0079] The personal care products of the present invention, such as body care products, can be used as a single ingredient or mixed with other stabilizers in bath and shower additives, preparations containing fragrances and flavoring substances, hair care products, deodorants and antiperspirants, decorative preparations, photoprotective formulations and preparations containing active ingredients.

[0080] The above body care products include, but are not limited to, body oils, body lotions, body gels, treatment creams, skin protective ointments, shaving preparations such as shaving foams or gels, skin powders such as baby powder, moisturizing gels, moisturizing sprays, revitalizing body sprays, cellulite gels, and peeling preparations.

[0081] Suitable bath and shower additives include shower gels, bath salts, bubble baths, and soaps. Fragrance- and flavor-containing preparations include perfumes, toners, and shaving lotions (aftershave preparations). Body care products may be in the form of, but are not limited to, creams, ointments, pastes, foams, gels, lotions, powders, makeup, sprays, sticks, or aerosols.

[0082] The above body care product may also include, but is not limited to, a stabilizing mixture, and optionally additional UV absorbers, sterically hindered amines, complexing agents, and phenolic or non-phenolic antioxidants.

[0083] The present invention provides a natural product-based antioxidant composition.

[0084] The present invention provides a composition that exhibits scalp improvement, hair loss prevention, and improvement effects based on natural substances.

[0085] The present invention provides a composition that can be taken or used for a long period of time without side effects.

[0086] Another embodiment of the present invention provides various formulations of food, detergent or external preparations containing the composition and capable of achieving the functional effects of the composition.

[0087] Figure 1 is about video image processing in an animal experiment according to one embodiment of the present invention.

[0088] The present invention relates to a composition for preventing and improving hair loss comprising an extract of the plant.

[0089] Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement them. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein.

[0090]

[0091] [Manufacturing Example: Preparation of Extract]

[0092] 1. Preparation of extract of the plant

[0093] After washing and cutting the paper plant, it was extracted with hot water. After extraction, it was filtered and concentrated to produce paper plant extract (AE).

[0094]

[0095] 2. Preparation of other extracts

[0096] Kelp extract (BE), lavender extract (CE), soybean extract (DE), mountain ash extract (EE), and eucommia ulmoides extract (FE) were prepared using the same method as the above AE.

[0097]

[0098] 3. Preparation of mixed composition

[0099] In order to confirm the synergistic effect of each mixed composition, a mixed composition was prepared with the composition shown in [Table 1] below.

[0100] M1M2M3M4M5M6M7M8M9M10M11M12AE100100100100100100100100100100100100BE10010010015020025030020020020020 0200CE-100100150200250300200200200200200DE--5103050803030303030EE-------0.1151020FE-------0.1151020

[0101] (Unit: parts by weight)

[0102] [Experimental Example: Activity Evaluation]

[0103] 1. Measurement of DPPH radical scavenging activity

[0104] The scavenging activity against the DPPH radical, a representative cation radical, was measured by the method of Gyamfi et al. First, 0.1 mM DPPH solution 1 and 50 mM Tris-Hcl buffer (pH 7.4) 450 were added to sample 50, mixed, and reacted at room temperature for 30 minutes. Afterwards, the absorbance was measured at a wavelength of 517 nm using a microplate reader (VersaMax, Molecular Devices, USA). The scavenging activity against the DPPH radical was expressed as scavenging capacity through regression analysis.

[0105] In order to objectively compare the effects according to each example, the result of the control using purified water was fixed at 1, and the results of each example were compared and evaluated on an index from 1 to 10, which is shown in [Table 2] below. The higher the index number, the better the radical scavenging activity.

[0106] conAEM1M2M3M4M5M6M7M8M9M10M11M12DPPH radical scavenging activity14433665468985

[0107] (Unit: Index)

[0108] 2. Measurement of total polyphenol content

[0109] The total polyphenol content was measured by adding 2 ml of 2% sodium carbonate and 100 μl of 50% Folin-Ciocalteu reagent to 100 μl of reagent according to the method of Dewanto et al. (Dewanto et al., 2002 J Agric Food Chem 50, 3010-3014), and measuring the absorbance at 720 nm. The content was calculated using a calibration curve of gallic acid (Sigma-Aldrich Co., USA).

[0110] In order to objectively compare the effects according to each example, the AE result was fixed at 1, and the results of each example were compared and evaluated using an index from 1 to 10, which is shown in [Table 3] below. The index below indicates that the polyphenol content is superior.

[0111] AEM1M2M3M4M5M6M7M8M9M10M11M12polyphenol content1111444344443

[0112] (Unit: Index)

[0113] 3. Evaluation of proliferation activity in mammary papilla cells

[0114] 5 × 10 human papilla cells (HFDPCs) (PromoCell, Heidelberg, Germany) 3 After dividing into cells / well, the medium was replaced on the first day and cultured for 24 hours. On the second day, CCK-8 (Cell Counting Kit-8) was measured (initial value average: 0.591) and sample treatment was performed before sample treatment. At this time, the sample was treated at 100 ppm. On the fifth day, CCK-8 was measured. The average of the control value was 0.554, confirming that the cells did not die and the number maintained the initial value. The media used in the experiment were DMEM (10% FBS, 1% P / S), depletion media: 5% charcoal stripped FBS containing phenol-red free DMEM media, SF (serum free) media - DMEM (1% P / S).

[0115] In order to objectively compare the effects according to each example, the result of the control using purified water was fixed at 1, and the results of each example were compared and evaluated on an index from 1 to 10, which is shown in [Table 4] below. The higher the index number, the better the proliferation activity of mammary papilla cells.

[0116] conAEM1M2M3M4M5M6M7M8M9M10M11M12Proliferative activity on dermal papilla cells13323566469984

[0117] (Unit: Index)

[0118] 4. Evaluation of mouse hair growth promotion activity

[0119] To evaluate the hair growth promoting activity of the composition according to the present invention, three mice (four in the control group) were selected for each group, and the effect on hair density of the mice in each group was evaluated. The control group was provided with only purified water, while the remaining groups were provided with each composition, and the effect of each composition on hair density was confirmed for 10 weeks.

[0120] In order to check the hair density, the same side of the mouse was photographed and the image was processed as in Fig. 1, and the density was evaluated by applying the body weight value of each mouse to the hair density obtained from the processed image.

[0121] In order to objectively compare the effects according to each example, the result of the control using purified water was fixed at 1, and the results of each example were compared and evaluated on an index of 1 to 10, which is shown in [Table 5] below. The index below indicates that the higher the number, the better the mouse hair density value and the better the hair growth promotion activity.

[0122] conAEM1M2M3M4M5M6M7M8M9M10M11M12hair growth promoting activity12112454147763

[0123] (Unit: Index)

[0124] Referring to the above experimental results, it can be seen that the extract of the plant of the present invention has antioxidant activity with excellent radical scavenging ability. It can also be confirmed that it promotes the proliferation of mammary papilla cells and has hair growth promoting activity.

[0125] In addition, in the case of the mixed composition, synergistic activity was observed in the composition range of M4 to M6, and it was confirmed that in the case of the above range, excellent hair loss prevention and improvement effects can be achieved through excellent antioxidant activity as well as proliferation and hair growth promotion activity of hair papilla cells. Therefore, in the case of the above range, a hair loss prevention and improvement composition that exhibits excellent effects with a smaller content can be provided, and thus excellent effects can be exhibited with a smaller content.

[0126] Meanwhile, an additional synergistic effect was observed in the case of M9 to M11. In particular, in the case of M9 to M11, the polyphenol content did not differ significantly from that of M4 to M7, but it was confirmed that along with the synergistic effect on antioxidant activity, hair papilla activity and hair growth promotion activity were increased. Therefore, it can be assumed that in the case of M9 to M11, the hair loss prevention and improvement effect is expressed through a different mechanism due to the interaction of different effective ingredients from M4 to M6.

[0127] Therefore, in the case of the above range, an excellent effect can be achieved with a smaller amount, and accordingly, the functional effect suggested by the present invention can be achieved while using it for a long period of time without problems such as side effects.

[0128]

[0129] Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concept of the present invention defined in the following claims also fall within the scope of the present invention.

[0130] The present invention relates to a composition for antioxidant activity, hair root improvement, and hair loss prevention and improvement, comprising an extract of the plant, as an active ingredient, and to a food product and an external preparation comprising the same. More specifically, the present invention provides a composition comprising an extract of the plant, as an active ingredient, which exhibits excellent antioxidant activity, and improves hair root activity and prevents or improves hair loss. In particular, the composition is free from side effects such as cytotoxicity and skin irritation, and thus can be used for a long period of time to achieve the above-described effects. Furthermore, the present invention provides a food product or a personal care product comprising the composition, or a variety of other formulations, so that products can be produced in various forms to achieve the above-described functions.

Claims

1. Containing extracts of the plant Composition for preventing and improving hair loss.

2. In paragraph 1, Further comprising a first extract selected from the group consisting of seaweed extract, seaweed extract, kelp extract, wakame extract, laver extract and mixtures thereof. Composition for preventing and improving hair loss.

3. In paragraph 2, Further comprising a second extract selected from the group consisting of lavender extract, mint extract, peppermint extract, basil extract, thyme extract and mixtures thereof. Composition for preventing and improving hair loss.

4. In paragraph 3, Contains more soybeans Composition for preventing and improving hair loss.

5. An antioxidant composition comprising a composition according to any one of claims 1 to 4.

6. A food comprising a composition according to any one of claims 1 to 4.

7. A functional food comprising a composition according to any one of claims 1 to 4.

8. A personal care product comprising a composition according to any one of claims 1 to 4.

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