External-use composition and method for enhancing fragrance of same

Abstract

The purpose of the present invention is to provide an external-use composition with which aroma is maintained for a long period of time after application to the skin. Another purpose of the present invention is to provide a method with which it is possible, in relation to an external-use composition, to provide sufficient fragrance after application to the skin, and to maintain the fragrance for a long period of time.　The present invention is an external-use composition containing (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4-position or 5-position, and (B) one or more components selected from the group consisting of (b-1) 1-6-valent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationized polymers.

Description

Composition for external use and method for enhancing fragrance thereof

[0001] The present invention relates to a composition for external use and a method for enhancing the fragrance thereof.

[0002] In recent years, people, both men and women, have become increasingly interested in odor etiquette. Research into various body odors has been intensively conducted, and the main causes of odors, such as sweat odor, underarm odor, foot odor, and body odor associated with aging, have been identified. Countermeasures against such body odors have been proposed, including masking with perfumes or cosmetics containing aromatic components, utilizing the odor-absorbing properties of charcoal (Patent Document 1), using extracts from the roots and rhizomes of Sanguinea chinensis (Patent Document 2), and using condensed persimmon tannins (Patent Document 3). Furthermore, a technique for rejuvenating body odor using lactone, a component characteristic of the body odor of young women, is also known (Patent Document 4).

[0003] In fragrance products such as perfumes and cosmetics, the long-lasting fragrance during use is an important factor in providing consumer satisfaction, a sense of refreshment, and a sense of elation, as well as increasing product value. To this end, the use of sustained-release fragrances, which incorporate techniques such as retaining the fragrance in a carrier, is becoming more common. However, increasing the amount of such sustained-release fragrances increases product costs and poses risks to formulation stability, such as coloring. Therefore, there is a strong demand for technology that enhances the fragrance release after application of sustained-release fragrances and efficiently releases fragrances.

[0004] JP 2002-145747 A JP 2011-183019 A JP 2001-302483 A WO 2019 / 059023

[0005] The present invention has been made in view of the above circumstances, and aims to provide a topical composition such as a cosmetic that, after application to the skin, provides an excellent fragrance from a sustained-release fragrance and further enhances the release of the fragrance. It is also an object of the present invention to provide a method for providing a topical composition that, after application to the skin, can release a sufficient fragrance and further enhance the release of the fragrance.

[0006] It is known that certain hydroxy fatty acids, such as 4-hydroxyundecanoic acid, and their salts undergo cyclization under heat or acidic conditions due to lipases on the skin. While these specific hydroxy fatty acids themselves are odorless, they emit fragrance upon cyclization to form γ-undecalactone or the like. Because these specific hydroxy fatty acids are thought to emit fragrance over a long period of time by gradually undergoing the above-mentioned reaction on the skin, they are expected to be components that can improve the persistence of fragrance after application to the skin. While developing topical compositions containing these specific hydroxy fatty acids, the inventors encountered the problem that, depending on the composition and skin condition, the fragrance components produced by the cyclization of the hydroxy fatty acids were weak, resulting in insufficient fragrance release for a fragranced product. To solve this problem, the inventors conducted extensive research and discovered that blending a mono- to hexavalent alkyl alcohol, an amphiphilic ester, a phenol derivative, or a cationic polymer with a topical composition containing the specific hydroxy fatty acid or its salt solves the above problem and enhances fragrance release after application to the skin, thereby completing the present invention. Specifically, the gist of the present invention is as follows.

[0007] [1] A topical composition comprising (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and having a hydroxy group at the 4th or 5th position, and (B) one or more components selected from the group consisting of (b-1) a mono- to hexahydric alkyl alcohol, (b-2) an amphiphilic ester, (b-3) a phenol derivative, and (b-4) a cationic polymer. [2] The topical composition according to [1], wherein component (A) comprises 4-hydroxyundecanoic acid or a salt thereof. [3] The topical composition according to [1] or [2], wherein, in component (B), component (b-1) comprises: (b-1-1) a monohydric alcohol having 2 carbon atoms, (b-1-2) a mono- or dihydric alcohol having 3 carbon atoms, (b-1-3) a trihydric alcohol having 3 carbon atoms, or (b-1-4) a mono- to hexahydric alcohol having 4 to 6 carbon atoms. [4] The topical composition according to [1] or [2], wherein component (B) comprises one or more components selected from the group consisting of (b-1) ethanol, glycerin, 1,3-butylene glycol, and dipropylene glycol; (b-2) bisethoxydiglycol cyclohexanedicarboxylate; (b-3) phenoxyethanol and isopropylmethylphenol; and (b-4) polyquaternium-10. [5] A method for enhancing the fragrance release of a topical composition after application to skin, comprising blending (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and having a hydroxy group at the 4th or 5th position, with one or more components selected from the group consisting of (b-1) mono- to hexavalent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers. [6] The method according to [5], wherein component (A) comprises 4-hydroxyundecanoic acid or a salt thereof. [7] The method according to [5] or [6], wherein in the component (B), the component (b-1) comprises: (b-1-1) a monohydric alcohol having 2 carbon atoms; (b-1-2) a monohydric or dihydric alcohol having 3 carbon atoms; (b-1-3) a trihydric alcohol having 3 carbon atoms; or (b-1-4) a monohydric to hexahydric alcohol having 4 to 6 carbon atoms.

[0008] According to the present invention, it is possible to provide a topical composition that maintains its fragrance for a long period of time after application to the skin. Furthermore, the topical composition of the present invention causes a sufficient fragrance to be released after application to the skin, and the fragrance can be maintained for a long period of time.

[0009] The present invention will be described in detail below. The terms used in this specification are to be interpreted in the sense commonly used in the art unless otherwise specified.

[0010] [Topical Composition] The topical composition of the present invention is characterized by containing (A) a hydroxy fatty acid or salt thereof having 10 or more carbon atoms and a hydroxy group at the 4th or 5th position (also referred to as "component (A)"), and (B) one or more components selected from the group consisting of (b-1) mono- to hexavalent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers (also referred to as "component (B)"). The topical composition of the present invention, having the above-described composition, can maintain its fragrance for a long period of time after application to the skin. Furthermore, the topical composition of the present invention can provide a sufficient fragrance after application to the skin, and can maintain the fragrance for a long period of time. In addition to the essential components (A) and (B), the topical composition of the present invention may also contain (C) a fragrance (excluding component (A)) and other components, to the extent that the effects of the present invention are not impaired. Each of these components is described in detail below.

[0011] <Component (A)> The topical composition of the present invention contains (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4th or 5th position. The hydroxy fatty acid of the present invention is a hydrocarbon having 10 or more carbon atoms and having a carboxyl group and a hydroxy group, the hydroxy group being at the 4th or 5th position, which becomes aromatic upon cyclization under heat, acidic conditions, or the like. The hydroxy fatty acid of the present invention may have an unsaturated bond and may be bonded to a substituent such as a methyl group.

[0012] The hydroxy fatty acid of the present invention preferably has 10 to 15 carbon atoms, more preferably 10 to 13 carbon atoms, and even more preferably 10 to 11 carbon atoms. The carbon chain of the hydroxy fatty acid is preferably linear. Examples of the hydroxy fatty acid of the present invention include 4-hydroxydecanoic acid, 4-hydroxyundecanoic acid, 4-hydroxydodecanoic acid, 4-hydroxytridecanoic acid, 4-hydroxytetradecanoic acid, 4-hydroxypentadecanoic acid, 4-hydroxyhexadecanoic acid, 5-hydroxydecanoic acid, 5-hydroxyundecanoic acid, 5-hydroxydodecanoic acid, 5-hydroxytridecanoic acid, 5-hydroxytetradecanoic acid, 5-hydroxypentadecanoic acid, and 5-hydroxyhexadecanoic acid. Among these, from the viewpoint of excellent aromatic properties after cyclization, preferred are those having a hydroxy group at the 4-position, with 4-hydroxydecanoic acid, 4-hydroxyundecanoic acid, and 4-hydroxydodecanoic acid being more preferred, and 4-hydroxyundecanoic acid being even more preferred.

[0013] Examples of the salts of hydroxy fatty acids in the present invention include alkali metal salts and alkaline earth metal salts of the above hydroxy fatty acids. Examples of alkali metal salts include sodium salts and potassium salts. Examples of alkaline earth metal salts include magnesium salts and calcium salts. Of these, alkali metal salts of hydroxy fatty acids are preferred, and sodium salts of hydroxy fatty acids are more preferred. Specific examples include sodium 4-hydroxydecanoate, sodium 4-hydroxyundecanoate, sodium 4-hydroxydodecanoate, sodium 4-hydroxytridecanoate, sodium 4-hydroxytetradecanoate, sodium 4-hydroxypentadecanoate, sodium 4-hydroxyhexadecanoate, sodium 5-hydroxydecanoate, sodium 5-hydroxyundecanoate, sodium 5-hydroxydodecanoate, sodium 5-hydroxytridecanoate, sodium 5-hydroxytetradecanoate, sodium 5-hydroxypentadecanoate, sodium 5-hydroxyhexadecanoate, potassium 4-hydroxydecanoate, potassium 4-hydroxyundecanoate, 4 ... potassium 5-hydroxytetradecanoate, sodium 5-hydroxypentadecanoate, potassium 5-hydroxyhexadecanoate, potassium 4-hydroxydecanoate, potassium 4-hydroxyundecanoate, 4-hydroxytridecanoate, potassium 4-hydroxydecanoate, potassium 4-hydroxyundecanoate, 4-hydroxytridecanoate, potassium 4-hydroxytetradecanoate, sodium 5-hydroxypentadecanoate, potassium 5-hydroxyhexadecanoate, potassium 4-hydroxy

[0123] Examples of the hydroxybenzoate include potassium 4-hydroxydodecanoate, potassium 4-hydroxytridecanoate, potassium 4-hydroxytetradecanoate, potassium 4-hydroxypentadecanoate, potassium 4-hydroxyhexadecanoate, potassium 5-hydroxydecanoate, potassium 5-hydroxyundecanoate, potassium 5-hydroxydodecanoate, potassium 5-hydroxytridecanoate, potassium 5-hydroxytetradecanoate, potassium 5-hydroxypentadecanoate, and potassium 5-hydroxyhexadecanoate, among which sodium 4-hydroxydecanoate, sodium 4-hydroxyundecanoate, and sodium 4-hydroxydodecanoate are preferred, and sodium 4-hydroxyundecanoate is more preferred.

[0014] As component (A) contained in the topical composition of the present invention, either the above-mentioned hydroxy fatty acids or their salts are sufficiently effective, but from the viewpoint of stability in the formulation, the above-mentioned salts of hydroxy fatty acids are preferred.

[0015] Examples of lactones that can be produced on the skin when the topical composition of the present invention is applied to the skin include γ-lactones such as γ-decalactone, γ-undecalactone, and γ-dodecalactone, and δ-lactones such as δ-decalactone, δ-undecalactone, and δ-dodecalactone.

[0016] The content of component (A) in the topical composition of the present invention is 0.00001% by weight to 10% by weight, and from the viewpoint of fragrance release after application to the skin, it is preferably 0.00005% by weight to 8% by weight, more preferably 0.0001% by weight to 5% by weight, even more preferably 0.0005% by weight to 3% by weight, particularly preferably 0.001% by weight to 2% by weight, and even more particularly preferably 0.01% by weight to 1% by weight. When two or more compounds are used in combination as component (A), the total amount falls within the above numerical range.

[0017] <Component (B)> In addition to the component (A) described above, the topical composition of the present invention contains one or more components selected from the group consisting of (B) (b-1) mono- to hexavalent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers. The component (A) in the topical composition is a compound that becomes fragrant through cyclization in the presence of lipase, acidic conditions, etc.; therefore, application of the topical composition to the skin is expected to result in gradual cyclization under the influence of skin lipases, etc., resulting in the release of a fragrance over a long period of time. However, the present inventors have encountered the problem that, depending on the composition and skin condition, topical compositions containing component (A) exhibit weak fragrance due to the aroma components produced by cyclization of hydroxy fatty acids, etc., resulting in insufficient fragrance release for fragranced products. To solve this problem, the inventors investigated numerous formulation components and found that the component (B) exhibits significant effects.

[0018] As the component (b-1), (b-1-1) a monohydric alcohol having 2 carbon atoms, (b-1-2) a monohydric or dihydric alcohol having 3 carbon atoms, (b-1-3) a trihydric alcohol having 3 carbon atoms, and (b-1-4) a monohydric to hexahydric alcohol having 4 to 6 carbon atoms are preferred.

[0019] As the (b-1-1) monohydric alcohol having 2 carbon atoms, ethanol is preferred; as the (b-1-2) monohydric or dihydric alcohol having 3 carbon atoms, propylene glycol (PG) and 1,3-propanediol are preferred; as the (b-1-3) trihydric alcohol having 3 carbon atoms, glycerin is preferred; as the (b-1-4) monohydric to hexahydric alcohol having 4 to 6 carbon atoms, butanol, 1,3-butylene glycol, 2,3-butylene glycol, pentyl alcohol, pentanediol, hexanol, hexanediol, dipropylene glycol, diglycerin and sorbitol are preferred; 1,3-butylene glycol, 2,3-butylene glycol, pentanediol, hexanediol and dipropylene glycol are more preferred, and 1,3-butylene glycol and dipropylene glycol are even more preferred.

[0020] As the component (b-1), the above (b-1-1) monohydric alcohol having 2 carbon atoms, the above (b-1-3) trihydric alcohol having 3 carbon atoms, and the above (b-1-4) monohydric to hexahydric alcohol having 4 to 6 carbon atoms are preferred, and among these, ethanol, glycerin, 1,3-butylene glycol, and dipropylene glycol are more preferred.

[0021] When the topical composition of the present invention contains the above-mentioned component (b-1) as component (B), the content of component (b-1) in the topical composition of the present invention is 0.00001% by weight to 70% by weight, and from the viewpoint of fragrance release after application to the skin, it is preferably 0.00005% by weight to 60% by weight, more preferably 0.0001% by weight to 40% by weight, even more preferably 0.0005% by weight to 20% by weight, and particularly preferably 0.001% by weight to 15% by weight. Two or more compounds may be used in combination as component (b-1), in which case the total amount should be within the above-mentioned numerical range.

[0022] When the topical composition of the present invention contains the above-mentioned component (b-1) as component (B), the ratio of the content (wt%) of component (b-1) to component (A) (the value obtained by dividing the content (wt%) of component (b-1) by the content (wt%) of component (A)) is preferably 5 to 2,500, more preferably 25 to 1,500, even more preferably 50 to 500, and even more preferably 100 to 300.

[0023] Examples of the (b-2) amphiphilic ester include bisethoxydiglycol cyclohexanedicarboxylate, methylpentanediol dineopentanoate, diethylpentanediol dineopentanoate, diethylhexyl sebacate, bis(polyoxyalkylene alkyl ether) dicarboxylate, polyglyceryl-10 (eicosanedioate / tetradecanedioate), diethoxyethyl succinate, etc. Of these, bisethoxydiglycol cyclohexanedicarboxylate is preferred from the viewpoint of the above-mentioned effects.

[0024] When the topical composition of the present invention contains the above-mentioned component (b-2) as component (B), the content of component (b-2) in the topical composition of the present invention is 0.0001% by weight to 30% by weight, and from the viewpoint of fragrance release after application to the skin, it is preferably 0.0005% by weight to 25% by weight, more preferably 0.001% by weight to 20% by weight, even more preferably 0.01% by weight to 20% by weight, and particularly preferably 0.1% by weight to 15% by weight. Two or more compounds may be used in combination as component (b-2), in which case the total amount should be within the above-mentioned numerical range.

[0025] When the topical composition of the present invention contains the above-mentioned component (b-2) as component (B), the ratio of the content (wt%) of component (b-2) to the content (wt%) of component (A) (the value obtained by dividing the content (wt%) of component (b-2) by the content (wt%) of component (A)) is preferably 0.5 to 500, more preferably 5 to 300, and even more preferably 10 to 100.

[0026] The (b-3) phenol derivative refers to a compound containing a phenol ring in the molecule, and the phenol ring in the molecule may have a substituent. Examples of phenol derivatives include phenoxyethanol, isopropylmethylphenol, salicylic acid, phenol, cresol, chlorocresol, xylenol, chloroxylenol, resorcinol, and orthophenylphenol. Of these, phenoxyethanol and isopropylmethylphenol are preferred, and phenoxyethanol is more preferred.

[0027] When the topical composition of the present invention contains the above-mentioned component (b-3) as component (B), the content of component (b-3) in the topical composition of the present invention is 0.0001% by weight to 10% by weight, and from the viewpoint of fragrance release after application to the skin, it is preferably 0.0005% by weight to 8% by weight, more preferably 0.001% by weight to 6% by weight, even more preferably 0.01% by weight to 5% by weight, and particularly preferably 0.05% by weight to 2% by weight. Two or more compounds may be used in combination as component (b-3), in which case the total amount should be within the above-mentioned numerical range.

[0028] When the topical composition of the present invention contains the above-mentioned component (b-3) as component (B), the ratio of the content (wt%) of component (b-3) to the content (wt%) of component (A) (the value obtained by dividing the content (wt%) of component (b-3) by the content (wt%) of component (A)) is preferably 0.1 to 100, more preferably 0.5 to 50, and even more preferably 1 to 25.

[0029] Examples of the (b-4) cationic polymer include cationic cellulose derivatives, diallyldimethylammonium chloride-acrylamide polymers, dimethylallylammonium chloride-acrylic acid copolymers, etc., and specific examples include Polyquaternium-7, Polyquaternium-10, Polyquaternium-22, Polyquaternium-39, etc. Among these, Polyquaternium-10 is preferred.

[0030] When the topical composition of the present invention contains the above-mentioned component (b-4) as component (B), the content of component (b-4) in the topical composition of the present invention is 0.0001% by weight to 50% by weight, and from the viewpoint of fragrance release after application to the skin, it is preferably 0.0005% by weight to 30% by weight, more preferably 0.001% by weight to 20% by weight, even more preferably 0.005% by weight to 15% by weight, particularly preferably 0.01% by weight to 10% by weight, and even more particularly preferably 0.1% by weight to 5% by weight. Two or more compounds may be used in combination as component (b-4), in which case the total amount should be within the above-mentioned numerical range.

[0031] When the topical composition of the present invention contains the above-mentioned component (b-4) as component (B), the ratio of the content (wt%) of component (b-4) to component (A) (the value obtained by dividing the content (wt%) of component (b-4) by the content (wt%) of component (A)) is preferably 0.5 to 500, more preferably 5 to 300, and even more preferably 10 to 100.

[0032] The total content of component (B) in the topical composition of the present invention is 0.000005% to 80% by weight, and from the viewpoint of fragrance release after application to the skin, it is preferably 0.00001% to 70% by weight, more preferably 0.00005% to 60% by weight, even more preferably 0.0001% to 50% by weight, even more preferably 0.0005% to 40% by weight, particularly preferably 0.001% to 30% by weight, and even more particularly preferably 0.01% to 20% by weight. Note that component (B) may be any one of compounds (b-1) to (b-4), or a combination of two or more compounds, as long as the total amount thereof falls within the above-mentioned range.

[0033] In the topical composition of the present invention, component (B) is preferably a combination of two or more of components (b-1) to (b-4), and more preferably three or more. When multiple components are selected from components (b-1) to (b-4), it is preferable to combine components selected from components (b-1) and (b-3).

[0034] In the topical composition of the present invention, the ratio of the total content (wt%) of component (B) to component (A) (the value obtained by dividing the total content (wt%) of components (B) by the content (wt%) of component (A)) is preferably 10 to 2,500, more preferably 50 to 2,000, and even more preferably 100 to 1,000.

[0035] <Component (C)> The topical composition of the present invention preferably contains a fragrance (C) (excluding component (A)) in addition to the above-described components (A) and (B). By further containing component (C), the topical composition of the present invention is able to emit a fragrance for a long period of time, starting immediately after use. Component (C) is not particularly limited as long as it is used as a component of topical skin preparations in the form of pharmaceuticals, quasi-drugs, or cosmetics. Component (C) may be a natural fragrance or a synthetic fragrance, but is preferably one containing an essential oil or an oil-soluble component. Furthermore, plant-based fragrances that evoke plants are preferred, and of these, fruit-based fragrances and floral fragrances are more preferred, with fruit-based fragrances being particularly preferred. Specific examples of component (C) include γ-decalactone, γ-undecalactone, δ-decalactone, δ-undecalactone, etc. Among these, γ-decalactone and γ-undecalactone are preferred from the viewpoint of achieving the effects of the invention, with γ-undecalactone being more preferred.

[0036] When component (C) is γ-undecalactone, the content of component (C) in the topical composition of the present invention is preferably 0.0001 to 10% by mass, more preferably 0.001 to 8%, even more preferably 0.01 to 5%, and particularly preferably 0.05 to 2%.

[0037] When the component (C) is γ-undecalactone, the ratio of the component (C) (wt %) to the component (A) (the value obtained by dividing the content (wt %) of the component (C) by the content (wt %) of the component (A)) is preferably 0.0025 to 200,000, more preferably 0.01 to 40,000, even more preferably 0.1 to 500, and particularly preferably 0.1 to 50.

[0038] <Optional Components> In addition to the components described above, the topical composition of the present invention may contain the following optional components to the extent that the effects of the present invention are not impaired.

[0039] The topical composition of the present invention may contain, as optional ingredients, for example, anti-inflammatory agents, cooling agents, disinfectants, preservatives, vitamins, organic acids, moisturizing ingredients, scrubbing agents, UV-absorbing ingredients, UV-scattering ingredients, astringent ingredients, peptides or derivatives thereof, amino acids or derivatives thereof, cleansing ingredients, keratin softening ingredients, cell activating ingredients, anti-aging ingredients, blood circulation promoting ingredients, whitening ingredients, powders, etc. In the topical composition of the present invention, these ingredients may be used alone or in combination of two or more.

[0040] Examples of anti-inflammatory agents include allantoin and its derivatives, glycyrrhetinic acid and its derivatives, glycyrrhizinic acid and its derivatives, salicylic acid derivatives, aminocaproic acid, azulene and its derivatives, zinc oxide, tocopherol acetate, hydrocortisone, prednisolone, and salts thereof. Specific examples include allantoin, allantoin chlorhydroxyaluminum, allantoin dihydroxyaluminum, glycyrrhetinic acid, glycyrrhetinic acid, stearyl glycyrrhetinate, glycol salicylate, methyl salicylate, epsilon aminocaproic acid, azulene, guaiazulene, and salts thereof. Here, "derivatives" refers to esters, ethers, alkylated products, glycosides, etc. of the compounds described. Here, "salts" refers to, for example, salts of mineral acids such as sulfuric acid, hydrochloric acid, or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts, etc. The same applies to the optional components described below.

[0041] Examples of the refreshing agent include terpenes such as camphor, 1-menthol, borneol, geraniol, cineole, anethole, limonene, and eugenol (which may be in any of the d-, l-, or dl-isomers); and essential oils such as eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine.

[0042] Examples of the disinfectants include chlorhexidine, acrinol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, alkyldiaminoglycine hydrochloride, piroctoolamine, and miconazole.

[0043] Examples of the preservatives include methyl benzoate, ethyl benzoate, propyl benzoate, sodium benzoate, chlorphenesin, and caprylhydroxamic acid.

[0044] The vitamins may be either water-soluble or oil-soluble vitamins, and examples thereof include vitamin B6s such as pyridoxine, pyridoxal, pyridoxamine, 5'-pyridoxal phosphate, and salts thereof (e.g., pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, pyridoxamine hydrochloride); pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethine, D-pantethine, coenzyme A, pantothenyl ethyl ether, and salts thereof; nicotinic acid, nicotine nicotinic acids such as dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1-(4-methylphenyl)ethyl nicotinate, nicotinamide, and salts thereof; γ-oryzanol, thiamine, dibenzoylthiamine, thiamine cetyl, thiamine monophosphate, thiamine diphosphate, thiamine triphosphate, and salts thereof (e.g., dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine Vitamin B1 such as nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine diphosphate hydrochloride, thiamine triphosphate monophosphate); Vitamin B2 such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate, and salts thereof; Vitamin B3 such as biotin, biocytin, and salts thereof; vitamins such as folic acid, pteroylglutamic acid, and salts thereof; vitamin B12s such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin, and salts thereof; water-soluble vitamin Cs such as ascorbic acid, dehydroascorbic acid, ascorbic acid phosphate, ascorbic acid-2-glucoside, 3-O-ethyl ascorbic acid, and ascorbic acid derivatives, and salts thereof (e.g., sodium ascorbate, sodium ascorbyl phosphate, magnesium ascorbyl phosphate);Vitamin E compounds such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate; oil-soluble vitamin C compounds such as ascorbigen-A, ascorbyl stearate, ascorbyl palmitate, L-ascorbyl dipalmitate, and ascorbyl tetra-2-hexyldecanoate; vitamin D compounds such as ergocalciferol and cholecalciferol; vitamin K compounds such as phylloquinone and farnoquinone; and vitamin-like factors such as ferulic acid.

[0045] Examples of the organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, and salts thereof. Examples of the salts include salts of mineral acids such as sulfuric acid, hydrochloric acid, and phosphoric acid, salts of organic acids such as maleic acid and methanesulfonic acid, salts of alkali metals such as sodium and potassium, alkaline earth metal salts, and ammonium salts.

[0046] Examples of the moisturizing component include diglycerin trehalose; polymeric compounds such as sodium hyaluronate, heparinoids, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and chitosan; amino acids such as glycine, aspartic acid, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidonecarboxylate; lipids such as ceramide, cholesterol, and phospholipids; and plant extracts such as chamomile extract, witch hazel extract, tea extract, and perilla extract.

[0047] Examples of the scrubbing agent include apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride granules, olive kernel powder, seawater dried granules, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, charcoal powder, hazelnut shell powder, polyethylene powder, and silicic anhydride.

[0048] Examples of the ultraviolet absorbing component include cinnamic acid-based ultraviolet absorbers such as glyceryl di-paramethoxycinnamate mono-2-ethylhexanoate; 2-ethylhexyl paramethoxycinnamate; 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate; 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol]; 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, diethylhexylbutamidotriazon, and 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine. benzalmalonate derivative ultraviolet absorbers such as dimethicodiethyl benzalmalonate; octocrylene ultraviolet absorbers such as 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester; imidazole sulfonic acid derivative ultraviolet absorbers such as 2-phenylbenzimidazole-5-sulfonic acid and disodium phenyldibenzimidazole tetrasulfonate; and benzophenone derivative ultraviolet absorbers such as 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and salts thereof, dihydroxydimethoxybenzophenone, dihydroxybenzophenone, or tetrahydroxybenzophenone.

[0049] Examples of the ultraviolet scattering component include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and silicic anhydride; these inorganic compounds coated with inorganic powder such as hydrous silicic acid, aluminum hydroxide, mica, and talc; compounds composited with resin powder such as polyamide, polyethylene, polyester, polystyrene, and nylon; and compounds further treated with silicone oil, aluminum salt of a fatty acid, or the like.

[0050] Examples of the astringent ingredient include zinc sulfate, aluminum chloride, zinc sulfophenol, and tannic acid.

[0051] Examples of the above peptides or derivatives thereof include keratin hydrolyzed peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin hydrolyzed peptides, collagen hydrolyzed peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzed peptides, conchiolin hydrolyzed peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptides, hydrolyzed wheat protein, casein hydrolyzed peptides, and acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.).

[0052] Examples of the amino acid or a derivative thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine.

[0053] Examples of the cleansing component include soaps selected from alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate, and potassium stearate, alkanolamide salts, and amino acid salts; amino acid surfactants such as sodium cocoyl glutamate and sodium cocoyl methyl taurate; ether sulfate ester salts such as sodium laureth sulfate; ether carboxylate salts such as sodium lauryl ether acetate; sulfosuccinate salts such as sodium alkyl sulfosuccinate; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide and coconut oil fatty acid diethanolamide; monoalkyl phosphate ester salts such as sodium lauryl phosphate and sodium polyoxyethylene lauryl ether phosphate; betaine-type amphoteric surfactants such as coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, lauryl dimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryl hydroxysulfobetaine, and sodium lauroylamidoethyl hydroxyethyl carboxymethyl betaine hydroxypropyl phosphate; and amino acid amphoteric surfactants such as sodium lauryl aminopropionate.

[0054] Examples of the keratin softening ingredients include lactic acid, salicylic acid, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea, glycolic acid, sulfur, and the like.

[0055] Examples of the cell activating component include amino acids such as γ-aminobutyric acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannin, flavonoid, saponin, and photosensitizer No. 301.

[0056] Examples of the anti-aging ingredients include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone.

[0057] Examples of the blood circulation-promoting component include components derived from plants (e.g., ginseng, Angelica tree, arnica, ginkgo, fennel, emmeisou, Dutch oak, chamomile, Roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, ginger, European hawthorn, European juniper, cnidium rhizome, Swertia japonica, thyme, clove, tangerine peel, chili pepper, angelica acutiloba, peach kernel, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, melissa, yuzu, coix seed, ryokucha, rosemary, rose hip, tangerine peel, angelica acutiloba, spruce, peach, apricot, walnut, corn, etc.); acetylcholine, ichthammol, cantharides tincture, gamma-oryzanol, cepharanthine, tolazoline, tocopherol nicotinate, glucosyl hesperidin, etc.).

[0058] Examples of the whitening ingredient include tocopherol, tranexamic acid, nicotinamide, ascorbic acid or a salt thereof, an ascorbic acid derivative or a salt thereof, and the like.

[0059] Examples of the powder component include starch octenyl succinate Al (starch aluminum octenyl succinate), talc, corn starch, magnesium hydroxide, anhydrous silicic acid, light anhydrous silicic acid, mica, hydroxyapatite, zinc oxide, titanium oxide, nylon powder, charcoal, kaolin, and calamine.

[0060] <pH> The pH of the topical composition of the present invention is usually 3.0 or more and 11.0 or less, preferably 3.0 or more, 4.5 or more, 5.0 or more, and preferably 11.0 or less, 10.0 or less, 9.0 or less, 8.0 or less, 7.0 or less.The pH of the topical composition of the present invention is preferably 3.0 or more and 10.0 or less, 3.0 or more and 9.0 or less, 3.0 or more and 8.0 or less, 3.0 or more and 7.0 or less, 4.5 or more and 11.0 or less, 4.5 or more and 10.0 or less, 4.5 or more and 9.0 or less, 4.5 or more and 8.0 or less, 4.5 or more and 7.0 or less, 5.0 or more and 11.0 or less, 5.0 or more and 10.0 or less, 5.0 or more and 9.0 or less, 5.0 or more and 8.0 or less, 5.0 or more and 7.0 or less.In addition, this pH can be adjusted, for example, by using a pH adjuster as described below.

[0061] <Method for producing topical composition> The method for producing the topical composition of the present invention is not particularly limited, and the composition can be produced by a conventional method by appropriately selecting and mixing the essential components (A) and (B), the component (C) that is added as needed, and other components (the above-mentioned optional components, the base or carrier, additives, etc. described below). The topical composition of the present invention may be an emulsified composition, a solubilized composition, or a dissolved composition.

[0062] The topical composition of the present invention can be used in products that are applied directly to the skin by spraying, spraying, or other methods, or in products that are applied to articles that come into direct contact with the skin, and can be used in cosmetics for the purpose of masking various odors emitted on the skin or imparting a pleasant fragrance. The topical composition of the present invention used for such purposes can be suitably used, for example, in skin care products such as lotions, emulsions, and serums, cleansing agents such as body soaps and facial cleansers, hair care products such as shampoos, treatments, and dry shampoos, cleansing agents, deodorants, antiperspirants, ointments, sticks, liquids, suspensions, emulsions (emulsions and creams), gels, liniments, lotions, poultices, mists, aerosols, powders, granules, and the like.

[0063] <Preparation> The topical composition of the present invention can be prepared in various formulations by mixing the essential components and other components described above with a base or carrier commonly used in cosmetics, pharmaceuticals, and quasi-drugs, and, if necessary, with the additives described below, according to conventional methods, followed by emulsification or solubilization as necessary. The formulation of the topical composition of the present invention is not particularly limited, and examples include ointments, solutions, suspensions, emulsions (milks and creams), gels, liniments, lotions, poultices, mists, aerosols, powders, and granules. Among these, liquid to semi-solid formulations are preferred, and solutions, lotions, ointments, gels, and emulsions are particularly useful. These formulations can be prepared according to conventional methods, such as those described in the General Provisions for Preparations in the 18th Edition of the Japanese Pharmacopoeia.

[0064] Examples of the base or carrier include hydrocarbons such as liquid paraffin, squalane, petrolatum, gelling hydrocarbons (such as Plastibase), ozokerite, α-olefin oligomers, and light liquid paraffin; silicone oils such as methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, silicone / alkyl chain co-modified polyether-modified silicone, silicone / alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin; oils and fats such as coconut oil, jojoba oil, olive oil, rice bran oil, and shea butter; waxes such as beeswax, candelilla wax, sunflower wax, and lanolin; higher alcohols such as cetyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, and cholesterol; ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose cellulose derivatives such as cellulose; polyvinylpyrrolidone; carrageenan; polyvinyl butyrate; polyethylene glycol; dioxane; butylene glycol adipic acid polyester; esters such as diisopropyl adipate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, and pentaerythritol tetra-2-ethylhexanoate; polysaccharides such as dextrin and maltodextrin; vinyl polymers such as carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether; and water.

[0065] The topical composition of the present invention may contain water as a base, and the amount of water in the formulation is preferably 1 to 99% by mass, more preferably 5 to 85% by mass, and even more preferably 10 to 80% by mass. From the viewpoint of achieving the effects of the present invention, the amount of water may be 30 to 80% by mass, 40 to 75% by mass, or 50 to 70% by mass.

[0066] When the topical composition of the present invention contains a base or carrier other than water, the base or carrier is preferably, for example, a higher alcohol, hydrocarbon, oil, ester, silicone oil, wax, or vinyl polymer, more preferably a higher alcohol, ester oil, silicone oil, or vinyl polymer. Among these components, cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl tri-2-ethylhexanoate, dimethicone, cyclomethicone, polyether-modified silicone, polyglycerin-modified silicone, or carboxyvinyl polymer is even more preferred.

[0067] The bases or carriers described above may be used alone or in combination of two or more. The amounts used may be appropriately selected from ranges known to those skilled in the art.

[0068] <Additives> The topical composition of the present invention may contain known additives added to cosmetics, pharmaceuticals, and quasi-drugs, such as surfactants, stabilizers, antioxidants, colorants, pearlescent agents, dispersants, chelating agents, pH adjusters, thickeners, and irritation reducers, within the scope of not impairing the effects of the present invention. These additives may be used alone or in combination of two or more.

[0069] The surfactant may be any of a nonionic surfactant, a cationic surfactant, an anionic surfactant, an amphoteric surfactant, and the like, and examples thereof include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), and polyoxyethylene hydrogenated castor oil 80; polyoxyethylene monolaurate Examples of suitable surfactants include polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), and polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ethers; alkyl glucosides; polyoxyalkylene alkyl ethers such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine; and silicone surfactants such as polyoxyethylene-methylpolysiloxane copolymers, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone. Among these, nonionic surfactants are preferred, and hydrogenated castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, and polyoxyalkylene alkyl ethers are more preferred.

[0070] Examples of the stabilizer include sucrose fatty acid esters, hydrogenated castor oil isostearate, hydrogenated castor oil isostearate, mannitol, cyclodextrin, and sodium stearoylmethyl taurate.

[0071] Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine ​​hydrochloride, sodium pyrosulfite, polyphenols, and fullerene.

[0072] Examples of the colorant include inorganic pigments and natural dyes.

[0073] Examples of the pearly luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

[0074] Examples of the dispersing agent include N-lauroyl-L-glutamic acid di(phytosteryl-2-octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl-behenyl-2-octyldodecyl), diethylhexyl sodium sulfosuccinate, polyglyceryl polyricinoleate, dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl), lecithin, acrylic acid / alkyl methacrylate copolymer, (acrylates / ethylhexyl acrylate / dimethicone methacrylate) copolymer, and the like.

[0075] Examples of the chelating agent include EDTA disodium salt, EDTA calcium disodium salt, and the like.

[0076] Examples of the pH adjuster include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.), etc. Among these, inorganic bases and / or organic bases are preferred, and potassium hydroxide and triethanolamine are more preferred.

[0077] Examples of the thickener include vinyl thickeners such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, (acrylates / alkyl acrylate (C10-30)) crosspolymer, (hydroxyethyl acrylate / acryloyldimethyltaurate Na) copolymer, (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer, cellulose thickeners such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, guar gum, pectin, pullulan, gelatin, locust bean gum, carrageenan, agar, xanthan gum, acrylates / alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, sodium chondroitin sulfate, hyaluronic acid, sodium hyaluronate, and the like. Of these, vinyl-based thickeners and cellulose-based thickeners are preferred, and carboxyvinyl polymers, (acrylates / C10-30 alkyl acrylate) crosspolymers, polyvinylpyrrolidone, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, and carboxyethyl cellulose are more preferred.

[0078] Examples of the irritation reducer include licorice extract, sodium alginate, gum arabic, polyvinylpyrrolidone, and the like.

[0079] [Method for enhancing fragrance release of topical composition] The present invention also includes a method for enhancing fragrance release of a topical composition after application to the skin, the method comprising blending (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and having a hydroxy group at the 4- or 5-position (also referred to as "component (A)") with (B) one or more components (also referred to as "component (B)") selected from the group consisting of (b-1) mono- to hexavalent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers.

[0080] Since component (A) in the topical composition is a compound that becomes aromatic when cyclized by lipase, acidic conditions, etc., it is expected that application of the topical composition to the skin will gradually promote cyclization due to the influence of skin lipase, etc., resulting in the release of a fragrance over a long period of time. However, as mentioned above, the present inventors faced the problem that, depending on the composition, the topical composition may not have a strong fragrance and may not be sufficiently effective as a fragrance product. In order to solve this problem, the inventors investigated many ingredients and found that component (B) exhibited a significant effect, thereby completing the method of the present invention.

[0081] The method of the present invention further comprises blending component (B) into a topical composition containing component (A) to obtain the topical composition of the present invention described above, which, when applied to the skin, enables the lactone fragrance to be fully released and the fragrance to be maintained on the skin for a long period of time. Therefore, the explanations given above regarding the topical composition of the present invention can be applied to the explanations of each component that can be used in the method of the present invention, such as component (A), component (B), optional component (C), and other components.

[0082] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0083] The topical compositions of Reference Example, Comparative Example 1, and Examples 1 to 8 were prepared according to the formulations shown in Table 1 below, using standard methods. 900 μl of each topical composition solution was soaked in cotton and placed in a 100 ml glass screw-cap bottle. The bottle was then capped and left to stand for 5 minutes, after which 1800 μl of artificial sweat (acidic) JIS L0848:2004 was poured over it. The bottle was then capped and left to stand at room temperature under room light for one week, after which the scent of each test product was evaluated based on the average of the scores given by three expert evaluation panelists. The evaluation criteria (scores) were based on the intensity of the lactone odor, with Comparative Example 1 being assigned a score of 0, and the evaluation was conducted on a 6-point scale as shown below.

[0084] (Rating) 5: The lactone odor is very strong compared to Comparative Example 1. 4: The lactone odor is strong compared to Comparative Example 1. 3: The lactone odor is strong compared to Comparative Example 1. 2: The lactone odor is slightly stronger compared to Comparative Example 1. 1: The lactone odor is slightly stronger compared to Comparative Example 1. 0: The lactone odor is equivalent to that of Comparative Example 1.

[0085]

[0086] As shown in Table 1, the Reference Example, in which artificial sweat was not added to a topical composition containing sodium 4-hydroxyundecanoate, was rated as having a stronger lactone odor (score 5) than Comparative Example 1, in which artificial sweat was added.

[0087] In Examples 1 to 8, the addition of ethanol, glycerin, BG (1,3-butylene glycol), DPG (dipropylene glycol), phenoxyethanol, menthol, bisethoxydiglycol cyclohexanedicarboxylate, polyquaternium-10, and IPMP (isopropylmethylphenol) to a topical composition containing sodium 4-hydroxyundecanoate resulted in a stronger fragrance compared to Comparative Example 1. In particular, the topical compositions containing glycerin, BG (1,3-butylene glycol), and phenoxyethanol were evaluated as having a much stronger lactone odor than Comparative Example 1 after one week of storage at room temperature (RT). Furthermore, the addition of ethanol and bisethoxydiglycol cyclohexanedicarboxylate also produced sufficient effects, and the addition of DPG (dipropylene glycol), polyquaternium-10, and IPMP also produced excellent effects. The fragrance-releasing effects and other effects achieved by the topical compositions of these Examples were significantly greater than those of conventional fragrance ingredients. Furthermore, in a formulation (Example 1') in which 0.1% of γ-undecalactone was added to the composition of Example 1 and the amount was adjusted by the water content, the amount of fragrance derived from sodium 4-hydroxyundecanoate increased as the amount of fragrance from γ-undecalactone decreased, demonstrating that the fragrance effect could be maintained for a long time. Furthermore, all of the compositions of the examples were formulations that had a long-lasting fragrance and also had an excellent feel when used.

[0088] Examples of formulations for the topical composition of the present invention are shown below.

[0089] Formulation Example 1: Body Cream (O / W) 1 Sodium 4-hydroxyundecanoate 0.5 wt % γ-undecalactone 0.1 wt % Ethanol 1 wt % Glycerin 6 wt % 1,3-butylene glycol 8 wt % Diethoxyethyl succinate 0.5 wt % Carboxyvinyl polymer 0.05 wt % Xanthan gum 0.1 wt % Polyoxyethylene hydrogenated castor oil (60 E.O.) 0.5 wt % PPG-6 decyltetradeceth-30 0.4 wt % Sorbitan stearate 1.0 wt % Caprylic / capric triglyceride 3 wt % Sugar squalane 10 wt % Liquid paraffin 2 wt % Dimethicone 1 wt % Macadamia nut oil fatty acid phytosteryl 1 wt % Beeswax 0.5 wt % Behenyl alcohol 1 wt % Stearyl alcohol 1% by weight Myristic acid 0.18% by weight Stearic acid 2.82% by weight Retinol palmitate 0.1% by weight Trehalose 1% by weight Methylparaben 0.15% by weight Water Balance Total 100% by weight

[0090] Formulation Example 2: Body Cream (O / W) 2: 4-hydroxyundecanoic acid sodium salt 0.1 wt %, propylene glycol 3 wt %, 1,3-propanediol 3 wt %, pentanediol 3 wt %, dipropylene glycol 1 wt %, diglycerin 1 wt %, cyclohexanedicarboxylate bisethoxydiglycol 1 wt %, phenoxyethanol 0.3 wt %, acrylic acid / alkyl methacrylate copolymer 0.1 wt %, hydroxyethyl cellulose 0.05 wt %, dilauroyl glutamic acid lysine sodium salt 0.1 wt %, glyceryl stearate 0.8 wt %, polyoxyethylene sorbitan isostearate (20 E.O.) 1.2 wt %, cetyl ethylhexanoate 2 wt %, jojoba oil 3 wt %, petrolatum 1 wt %, N-lauroyl-L-glutamine sanshiji (Phytosteryl 2-octyldodecyl) 0.5% by weight Shea butter 0.7% by weight Cetyl alcohol 0.8% by weight Dipotassium glycyrrhizinate 0.05% by weight Triethanolamine 0.05% by weight Sodium benzoate 0.2% by weight Water Balance Total 100% by weight

[0091] <Formulation Example 3: Body Cream (O / W) 3> Sodium 4-hydroxydecanoate 0.8% by weight, γ-decalactone 0.05% by weight, glycerin 5% by weight 2,3-butylene glycol 7% by weight, hexanediol 1% by weight, sorbitol 1% by weight (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 1% by weight, isopropylmethylphenol 0.1% by weight, carboxyvinyl polymer 0.2% by weight, xanthan gum 0.2% by weight, hydrogenated lecithin 0.2% by weight, sorbitan stearate 0.5% by weight, ceteth-20 1% by weight, olive oil 8% by weight, dimethicone 0.4% by weight, dilinoleic acid di (phytosteryl / isostearyl / cetyl / stearyl / behenyl) 1% by weight, shea butter 0.2% by weight, stearyl alcohol 0.5% by weight, glycyrrhizic acid 2K 0.1% by weight, ascorbic acid glucoside 2% by weight, methyl gluceth-10 0.5% by weight, arginine 0.01% by weight, citric acid 0.05% by weight, sodium citrate 0.07% by weight, chlorphenesin 0.1% by weight, water, balance, total 100% by weight,

[0092] Formulation Example 4: Body Lotion Sodium 4-hydroxyundecanoate 2% by weight 1,3-propanediol 2% by weight 1,3-butylene glycol 3% by weight Sorbitol 2% by weight (eicosanedioic acid / tetradecanedioic acid) Polyglyceryl-10 0.5% by weight Phenoxyethanol 0.2% by weight Xanthan gum 0.5% by weight Sodium dilauramidoglutamide lysine 1% by weight Cetyl ethylhexanoate 8% by weight Sugar squalane 8% by weight Cetearyl alcohol 3% by weight Water Balance Total 100% by weight

[0093] Formulation Example 5: Body Lotion Sodium 5-hydroxydecanoate 1 wt % Glycerin 5 wt % 1,3-butylene glycol 10 wt % Hexanediol 2 wt % Hydroxyethylcellulose dimethyldiallyl ammonium chloride 0.1 wt % Acrylic acid / alkyl methacrylate copolymer 0.3 wt % Sorbitan stearate 0.3 wt % Polyoxyethylene sorbitan isostearate (20 E.O.) 0.5 wt % Caprylic / capric triglyceride 8 wt % Liquid paraffin 3 wt % N-lauroyl-L-glutamine sanshiji (phytosteryl 2-octyldodecyl) 1 wt % Behenyl alcohol 0.2 wt % Stearyl alcohol 2 wt % Trehalose 0.5 wt % Sodium hydroxide 0.01 wt % Methylparaben 0.1 wt % Ethylparaben 0.1 wt % Water Remaining Total 100% by weight

[0094] Formulation Example 6: Body Sheet 1 Sodium 4-hydroxyundecanoate 1.5% by weight Ethanol 5% by weight 1,3-butylene glycol 8% by weight Pentanediol 2% by weight Hexanediol 1% by weight Diglycerin 3% by weight Dimethyldiallylammonium chloride-acrylamide copolymer 0.1% by weight Xanthan gum 0.01% by weight Arginine 0.2% by weight Sodium benzoate 0.1% by weight Water Balance Total 100% by weight

[0095] Formulation Example 7: Body Sheet 2 Sodium 5-hydroxyundecanoate 1 wt % Propylene glycol 6 wt % Glycerin 9 wt % Dipropylene glycol 9 wt % Sorbitol 3 wt % Bisethoxydiglycol cyclohexanedicarboxylate 3 wt % Isopropylmethylphenol 0.05 wt % O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride 0.3 wt % Hydroxyethylcellulose 0.1 wt % Sodium benzoate 0.05 wt % Water Balance Total 100 wt %

[0096] Formulation Example 8: Hair Mist Sodium 4-hydroxyundecanoate 2.5% by weight Ethanol 20% by weight Sorbitol 5% by weight Bisethoxydiglycol cyclohexanedicarboxylate 5% by weight Dimethyldiallylammonium chloride-acrylamide copolymer 0.2% by weight Acrylamide-acrylic acid-dimethyldiallylammonium chloride copolymer solution 0.2% by weight Hydrogenated lecithin 0.05% by weight Chlorphenesin 0.05% by weight Water Balance Total 100% by weight

[0097] Formulation Example 9: Gel for delicate areas: Sodium 4-hydroxydecanoate 1% by weight, Diethoxyethyl succinate 1% by weight, (eicosanedioic acid / tetradecanedioic acid) Polyglyceryl-10 1.5% by weight, Phenoxyethanol 0.1% by weight, Isopropylmethylphenol 0.05% by weight, (Acryloyldimethyltaurate ammonium / VP) copolymer 0.1% by weight, (Acrylates / Steareth-20 Itaconate) copolymer 0.05% by weight, Sodium dilauramidoglutamide lysine 0.05% by weight, Hydrogenated lecithin 0.1% by weight, Glyceryl stearate 0.05% by weight, Jojoba oil 0.1% by weight, Dipotassium glycyrrhizinate 0.5% by weight, Methyl gluceth-10 1% by weight, Trehalose 2% by weight, Sodium hydroxide 0.1% by weight, Chlorphenesin 0.2% by weight Water Remaining Total 100% by weight

[0098] Formulation Example 10: Mist for delicate areas Sodium 4-hydroxyundecanoate 1.2% by weight Glycerin 10% by weight 1,3-butylene glycol 5% by weight Diglycerin 5% by weight Phenoxyethanol 0.2% by weight Isopropylmethylphenol 0.1% by weight Hydroxyethylcellulose 0.2% by weight Sodium dilauroyl glutamate lysine 0.5% by weight Citric acid 0.1% by weight Sodium citrate 0.2% by weight Water Balance Total 100% by weight

[0099] Formulation Example 11: Fabric Mist Sodium 4-hydroxyundecanoate 3% by weight Ethanol 70% by weight Water Balance Total 100% by weight

[0100] Formulation Example 12: Antiperspirant Cream (W / O) Sodium 4-hydroxydecanoate 0.5 wt% 1,3-butylene glycol 5 wt% Hexanediol 1 wt% Phenoxyethanol 0.3 wt% Isopropylmethylphenol 0.1 wt% Sorbitan stearate 2 wt% Polyoxyethylene sorbitan isostearate (20 E.O.) 2 wt% Glyceryl tri(caprylate / caprate) 10 wt% Cetyl ethylhexanoate 5 wt% Liquid paraffin 10 wt% Dimethicone 20 wt% Phytosteryl macadamiate 1 wt% Beeswax 1 wt% Behenyl alcohol 3 wt% Aluminum chlorohydrate 1 wt% Silica 3 wt% Talc 5 wt% Water Balance Total 100 wt%

[0101] Formulation Example 13: Antiperspirant Gel Sodium 5-hydroxydecanoate 0.3 wt% Ethanol 10 wt% Pentanediol 1 wt% Diglycerin 5 wt% Isopropylmethylphenol 0.3 wt% Carboxyvinyl polymer 0.5 wt% Xanthan gum 0.3 wt% Polyoxyethylene hydrogenated castor oil (60 E.O.) 3 wt% Cetyl ethylhexanoate 1 wt% Sodium hydroxide 0.1 wt% Water Balance Total 100 wt%

[0102] Formulation Example 14: Antiperspirant Mist Sodium 4-hydroxyundecanoate 0.1% by weight Ethanol 60% by weight Glycerin 3% by weight 1,3-butylene glycol 3% by weight Diethoxyethyl succinate 1% by weight Isopropylmethylphenol 0.1% by weight Acrylamide-acrylic acid-dimethyldiallyl ammonium chloride copolymer solution 0.1% by weight Hydroxyethylcellulose 0.1% by weight Aluminum chlorohydrate 1% by weight Silica 10% by weight Water Balance Total 100% by weight

[0103] <Formulation Example 15: Sunscreen Gel> Sodium 4-hydroxyundecanoate 0.3% by weight Ethanol 5% by weight Glycerin 3% by weight 1,3-butylene glycol 5% by weight, pentanediol 1% by weight, diethoxyethyl succinate 1% by weight, phenoxyethanol 0.3% by weight, acrylamide, acrylic acid, dimethyldiallyl chloride ammonium copolymer liquid 0.1% by weight, carboxyvinyl polymer 0.8% by weight (acryloyldimethyltaurate ammonium / VP) copolymer 0.5% by weight, polyoxyethylene hydrogenated castor oil (60 E.O.) 1% by weight, sorbitan stearate 1% by weight, tri(caprylic acid / capric acid) glyceryl 3% by weight, cetyl ethylhexanoate 3% by weight, sugar squalane 2% by weight, dimethicone 5% by weight, ethylhexyl paramethoxycinnamate 9% by weight, polysilicone-15 3% by weight, ethylhexyl triazone 0.5% by weight, diethylamino hydroxybenzoyl hexyl benzoate 1% by weight, bis-ethylhexyloxyphenol methoxyphenyl Triazine 1.5% by weight, Cetyl alcohol 1% by weight, Stearyl alcohol 1% by weight, Glycyrrhizic acid 2K 0.1% by weight, Triethanolamine 0.5% by weight, Water, Remainder Total 100% by weight,

[0104] Formulation Example 16: Body Powder Glycerin 1% by weight (eicosanedioic acid / tetradecanedioic acid) Polyglyceryl-10 0.3% by weight Phenoxyethanol 0.5% by weight Dimethicone 2% by weight Silica 81.2% by weight Zinc myristate 15% by weight Total 100% by weight

[0105] Formulation Example 17: Body Soap Sodium 4-hydroxyundecanoate 0.1 wt % Propylene glycol 3 wt % Glycerin 1 wt % Dipropylene glycol 1 wt % Phenoxyethanol 0.3 wt % Isopropylmethylphenol 0.1 wt % O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride 0.1 wt % Hydroxyethylcellulose 0.5 wt % Sodium dilauramidoglutamide lysine 0.1 wt % POE lauryl ether acetate 3 wt % Coconut oil fatty acid aminopropyl betaine 4 wt % Lauric acid 6 wt % Myristic acid 6 wt % Potassium hydroxide 3.4 wt % Methylparaben 0.1 wt % Water Balance Total 100 wt %

[0106] Formulation Example 18: Shampoo Sodium 5-hydroxydecanoate 0.05 wt% Sodium 5-hydroxyundecanoate 0.1 wt% 1,3-propanediol 1 wt% Glycerin 2 wt% Diglycerin 1 wt% Sorbitol 3 wt% Bisethoxydiglycol cyclohexanedicarboxylate 0.5 wt% Phenoxyethanol 0.4 wt% O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride 0.4 wt% Xanthan gum 0.3 wt% Sodium cocoyl glutamate 6 wt% Cocoyl aminopropyl betaine 7 wt% Cocamide MEA 1 wt% Decyl glucoside 3 wt% Jojoba oil 0.1 wt% Arginine 0.1 wt% Citric acid 0.3 wt% Sodium citrate 0.1 wt% Sodium benzoate 0.2 wt% Water Remaining amount: Total 100% by weight

[0107] Formulation Example 19: Treatment Sodium 4-hydroxyundecanoate 0.2 wt% Propylene glycol 2 wt% Glycerin 2 wt% Diglycerin 2 wt% Guar hydroxypropyltrimonium chloride 0.5 wt% Hydroxyethyl cellulose 0.2 wt% Behentrimonium chloride 1.5 wt% Cetyl ethylhexanoate 1 wt% Liquid paraffin 3 wt% Dimethicone 2.5 wt% Shea butter 3 wt% Beeswax 0.5 wt% Behenyl alcohol 1 wt% Cetyl alcohol 1.5 wt% Stearyl alcohol 1 wt% Sodium benzoate 0.4 wt% Water Balance Total 100 wt%

[0108] Formulation Example 20: After-bath treatment Sodium 4-hydroxydecanoate 0.7 wt % Ethanol 1 wt % Propylene glycol 0.5 wt % 1,3-butylene glycol 1 wt % Dipropylene glycol 0.5 wt % Bisethoxydiglycol cyclohexanedicarboxylate 0.2 wt % Phenoxyethanol 0.2 wt % Guar hydroxypropyltrimonium chloride 0.1 wt % Xanthan gum 0.2 wt % Sodium dilauramidoglutamide lysine 0.8 wt % Laureth-9 2 wt % Steartrimonium chloride 0.2 wt % Phenyl trimethicone 8 wt % Behenyl alcohol 0.5 wt % Water Balance Total 100 wt %

[0109] Formulation Example 21: Femcare Cleanser Sodium 4-hydroxyundecanoate 0.5 wt% Glycerin 1 wt% Sorbitol 1 wt% Isopropylmethylphenol 0.05 wt% O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride 0.1 wt% Carboxyvinyl polymer 0.5 wt% Sodium cocoyl glutamate 5 wt% Cocoyl alanine TEA 2 wt% Cocoyl aminopropyl betaine 3 wt% Cocamide DEA 0.5 wt% Decyl glucoside 2 wt% Sugar squalane 0.1 wt% Citric acid 0.2 wt% Sodium benzoate 0.1 wt% Water Balance Total 100 wt%

[0110] According to the present invention, it is possible to provide a topical composition that maintains its fragrance for a long period of time after application to the skin. Furthermore, the topical composition of the present invention can provide a sufficient fragrance after application to the skin, and can further maintain the fragrance for a long period of time.

Claims

1. A composition for external use comprising: (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and having a hydroxy group at the 4th or 5th position; and (B) one or more components selected from the group consisting of (b-1) mono- to hexa-valent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers.

2. The topical composition according to claim 1, wherein component (A) comprises 4-hydroxyundecanoic acid or a salt thereof.

3. The topical composition according to claim 1 or 2, wherein in the component (B), the component (b-1) includes: (b-1-1) a monohydric alcohol having 2 carbon atoms; (b-1-2) a monohydric or dihydric alcohol having 3 carbon atoms; (b-1-3) a trihydric alcohol having 3 carbon atoms; or (b-1-4) a monohydric to hexahydric alcohol having 4 to 6 carbon atoms.

4. The topical composition according to claim 1 or 2, wherein the component (B) comprises one or more components selected from the group consisting of ethanol, glycerin, 1,3-butylene glycol, and dipropylene glycol as the component (b-1), bisethoxydiglycol cyclohexanedicarboxylate as the component (b-2), phenoxyethanol and isopropylmethylphenol as the component (b-3), and polyquaternium-10 as the component (b-4).

5. A method for enhancing the fragrance of an externally applied composition after application to the skin, comprising blending (A) an externally applied composition containing a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4- or 5-position, and (B) one or more components selected from the group consisting of (b-1) mono- to hexavalent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers.

6. The method of claim 5, wherein component (A) comprises 4-hydroxyundecanoic acid or a salt thereof.

7. The method according to claim 5 or 6, wherein in the component (B), the component (b-1) comprises: (b-1-1) a monohydric alcohol having 2 carbon atoms; (b-1-2) a monohydric or dihydric alcohol having 3 carbon atoms; (b-1-3) a trihydric alcohol having 3 carbon atoms; or (b-1-4) a monohydric to hexahydric alcohol having 4 to 6 carbon atoms.

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