Biosensor

Abstract

The present invention relates to a biosensor attached to the skin of a user, the biosensor enabling the continuous measurement of a sample without damaging a sensor, the biosensor comprising: a substrate; an adhesive part contacting the skin of a user; and a channel part formed between the substrate and the skin of the user. The channel part comprises: a collecting part for collecting a sample in liquid form; a moving channel for moving the sample collected by the collecting part; a measuring part having positioned thereat a sensor part for measuring, from the collected sample, the concentration of an object being measured; and a discharge part for discharging the measured sample, wherein the sensor part is formed at a predetermined interval from the skin of the user.

Description

biosensor

[0001] The present invention relates to a biosensor.

[0002]

[0003] A biosensor is a general term for a device or element that can confirm the presence or amount of a target substance (analyte) by reacting the target substance (analyte) to be analyzed with a bio-receptor with selective specificity and measuring the degree of the reaction with a signal transducer.

[0004] Biosensors are classified into electrochemical sensors, thermal sensors, optical sensors, etc. according to their conversion method, and recently, they are named variously as glucose sensors, cell sensors, immune biosensors, DNA chips, etc. according to the type of target substance to be analyzed.

[0005] Among these, electrochemical sensors are widely used as a conversion method for biosensors to date because they can convert the amount of biological samples into electrical signals that are easy to process.

[0006] Korean Patent Publication No. 10-2004-0105429 is also an invention regarding an electrochemical biosensor using blood as a sample, and provides a blood sugar sensor capable of reducing measurement errors according to the amount of hematocrit.

[0007] However, blood glucose sensors that use blood are invasive and therefore difficult for everyone to use, so non-invasive biosensors that use bodily fluids such as saliva, sweat, and tears are being developed.

[0008] Biosensors targeting these body fluids are in the form of sensors that can collect and analyze body fluids on their own while being directly attached to the skin. By using the body fluids, samples can be collected continuously and non-invasively, and this has the advantage of allowing easy acquisition of health status information.

[0009] Korean Patent Publication No. 10-2023-0011166 provides a non-invasive biosensor as a sweat sensor patch attached to the skin.

[0010] However, since the sensor is structured to be in direct contact with the skin, there is a problem that the sensor may be damaged due to friction with the skin.

[0011] In addition, conventional non-invasive biosensors have limitations in that the collection and discharge of samples are not smooth even when attached to the skin, making continuous measurement of the collected samples impossible, and thus, there was a problem in that cleaning and re-measurement of the sensor were inevitable.

[0012] Therefore, there is a need to develop a biosensor that enables smooth movement of the captured sample from the capture unit to the discharge unit and continuous measurement of the sample without damage to the sensor.

[0013]

[0014] The present invention is intended to improve the above-described conventional technical problems, and the purpose of the invention is to provide a biosensor capable of continuous measurement of a sample by allowing smooth movement of the sample from a collection unit to a discharge unit without damage to the sensor.

[0015] However, the problems that the present invention seeks to solve are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

[0016]

[0017] The present invention relates to a biosensor attached to a user's skin, comprising: a substrate; an adhesive portion that comes into contact with the user's skin; and a channel portion formed between the substrate and the user's skin, wherein the channel portion comprises: a collection portion that collects a sample in a liquid state; a movement channel that moves the sample collected by the collection portion; a measurement portion in which a sensor portion that measures the concentration of a measurement target from the collected sample is located; and a discharge portion through which the measured sample is discharged, wherein the sensor portion is formed at a predetermined distance from the user's skin.

[0018] In the first aspect of the present invention, the substrate may have a surface on the side forming the channel portion that is hydrophilic.

[0019] In the second aspect of the present invention, the adhesive portion may include at least one selected from the group consisting of an acrylic adhesive, a rubber adhesive, a silicone adhesive, a urethane adhesive, a polyvinyl alcohol adhesive, a polyvinyl pyrrolidone adhesive, a polyacrylamide adhesive, a cellulose adhesive, and a vinyl alkyl ether adhesive.

[0020] In the third aspect of the present invention, the channel portion may be formed between a portion of the substrate where the adhesive portion is not formed and the user's skin.

[0021] In the fourth aspect of the present invention, the moving channel may be shaped to connect the capturing section, the measuring section, and the discharge section, and have a width that gradually decreases from the capturing section side to the discharge section side.

[0022] The present invention, in its fifth aspect, may include a plurality of capturing units.

[0023] In the sixth aspect of the present invention, the plurality of capturing units may be connected to the moving channel through a plurality of passages.

[0024] In the seventh aspect, the present invention may further include a support formed between the substrate and the adhesive portion to include the capturing portion, the moving channel, the measuring portion, and the discharge portion.

[0025] In the eighth aspect of the present invention, the sensor unit may be separable.

[0026]

[0027] A biosensor according to one embodiment of the present invention enables continuous measurement of a sample by allowing smooth movement of a captured sample from a capture portion to a discharge portion without damage to the sensor.

[0028]

[0029] Figure 1 is an exploded perspective view showing a biosensor according to one embodiment of the present invention.

[0030] Figure 2 is a perspective view showing a biosensor according to one embodiment of the present invention.

[0031] Figure 3 is an exploded perspective view showing a biosensor according to another embodiment of the present invention.

[0032] Figure 4 is a perspective view showing a biosensor according to another embodiment of the present invention.

[0033] Fig. 5 is a cross-sectional view showing a surface cut along line A-A' of Fig. 4.

[0034] Figure 6 is a photograph of a biosensor prepared and manufactured according to Example 2.

[0035] Figures 7a and 7b are photographs showing the experimental results of samples injected into the biosensors of Examples 1 and 2.

[0036]

[0037] What each symbol represents is as follows:

[0038] 10: Skin 30: Sensor part

[0039] 100: substrate 200: adhesive

[0040] 300: Channel section 310: Capture section

[0041] 320: Moving channel 330: Measuring section

[0042] 340: exhaust part 400: support

[0043]

[0044] The present invention relates to a biosensor attached to a user's skin, comprising: a substrate; an adhesive portion that comes into contact with the user's skin; and a channel portion formed between the substrate and the user's skin, wherein the channel portion comprises: a collection portion that collects a sample in a liquid state; a movement channel that moves the sample collected by the collection portion; a measurement portion in which a sensor portion that measures the concentration of a measurement target from the collected sample is located; and a discharge portion through which the measured sample is discharged, wherein the sensor portion is formed at a predetermined distance from the user's skin.

[0045]

[0046] In the biosensor of the present invention, the sample to be detected may be a biological sample such as blood, body fluid (saliva, sweat, tears, etc.), urine, etc., and may be another liquid sample, but from the perspective of measuring by attaching the sample to the skin, body fluid (saliva, sweat, tears, etc.) is preferred.

[0047]

[0048] Hereinafter, embodiments of the present invention will be described in more detail with reference to the drawings. However, the following drawings attached to this specification illustrate preferred embodiments of the present invention and, together with the contents of the invention described above, serve to further understand the technical concept of the present invention. Therefore, the present invention should not be interpreted as being limited to the matters described in such drawings.

[0049] The terminology used herein is for the purpose of describing embodiments and is not intended to limit the present invention. In this specification, singular forms also include plural forms, unless specifically stated otherwise. For example, "capture unit" as used herein may refer to at least one capture unit among a plurality of capture units.

[0050] As used herein, the terms "comprises" and / or "comprising" are used to mean that they do not exclude the presence or addition of one or more other components, steps, operations, and / or elements other than the components, steps, operations, and / or elements mentioned. Like reference numerals refer to like elements throughout the specification.

[0051] Spatially relative terms such as "below," "bottom," "above," and "top" can be used to easily describe the relationship between one element or component and other elements or components, as illustrated in the drawings. Spatially relative terms should be understood to include different orientations of the elements during use or operation in addition to the orientations depicted in the drawings. For example, if an element depicted in the drawings were flipped over, an element described as being "below" or "bottom" of another element could end up being placed "above" or "top" of the other element. Thus, exemplary terms such as "bottom" can include both below and above orientations. Elements can also be oriented in other directions, and thus spatially relative terms can be interpreted accordingly.

[0052]

[0053] Figures 1 and 2 are an exploded perspective view and a perspective view, respectively, of a biosensor according to one embodiment of the present invention. Figures 3 and 4 are an exploded perspective view and a perspective view, respectively, of a biosensor according to another embodiment of the present invention, and Figure 5 is a cross-sectional view taken along line A-A' of Figure 4.

[0054]

[0055] Referring to FIGS. 1 to 5, a biosensor according to an embodiment of the present invention includes a substrate (100), an adhesive portion (200), and a channel portion (300), and the channel portion (300) may include a capturing portion (310), a moving channel (320), a measuring portion (330), and an exhaust portion (340).

[0056]

[0057] The above substrate (100) serves to provide a structural base for the components that make up the biosensor.

[0058] The above substrate (100) may be made of a rigid material such as glass or may be implemented in the form of a film having flexible properties, and may be used as a conventional or later developed material.

[0059] In one or more embodiments, the substrate (100) may be formed of a polyester resin such as silicon, glass, glass epoxy, ceramic, polyethylene naphthalate (PET), polybutylene terephthalate; a cellulose resin such as diacetyl cellulose, triacetyl cellulose; a polycarbonate resin; an acrylic resin such as polymethyl (meth)acrylate, polyethyl (meth)acrylate; a styrene resin such as polystyrene, an acrylonitrile-styrene copolymer; a polyolefin resin such as polyethylene, polypropylene, a polyolefin having a cyclo- or norbornene structure, or an ethylene-propylene copolymer; a vinyl chloride resin; an amide resin such as nylon, an aromatic polyamide; an imide resin; a polyethersulfone resin; a sulfone resin; a polyether ether ketone resin; a sulfated polyphenylene resin; a vinyl alcohol resin; a vinylidene chloride resin. It may be a film composed of a thermoplastic resin such as a vinyl butyral resin; an allylate resin; a polyoxymethylene resin; an epoxy resin, and the like, and a film composed of a blend of the above thermoplastic resins may also be used. In addition, a film composed of a thermosetting resin such as a (meth)acrylic resin, a urethane resin, an acrylic urethane resin, an epoxy resin, a silicone resin, or an ultraviolet-curable resin may be used, but is not limited thereto.

[0060] The thickness of the above substrate (100) is not particularly limited, but generally, considering workability such as strength and handleability, thin layer property, etc., it may be 1 to 500 ㎛, preferably 1 to 300 ㎛, and more preferably 5 to 200 ㎛.

[0061] The above substrate (100) may contain one or more suitable additives. The additives may include, for example, ultraviolet absorbers, antioxidants, lubricants, plasticizers, release agents, anti-coloring agents, flame retardants, nucleating agents, antistatic agents, pigments, colorants, etc.

[0062] The above substrate (100) may have a structure including various functional layers, such as a hard coating layer, an anti-reflection layer, and a gas barrier layer, on one or both sides of the substrate. The functional layers are not limited to those described above, and may include various functional layers depending on the intended use.

[0063] The above substrate (100) may be surface-treated as needed, and the surface treatment may include, for example, dry treatment such as plasma treatment, corona treatment, primer treatment, chemical treatment such as alkali treatment including saponification treatment, etc.

[0064] In addition, the substrate (100) may be surface-treated to make the surface in contact with the sample of the channel section (300) hydrophilic, so as to facilitate movement of the sample. For example, the surface may be treated by coating a solution containing a hydrophilic polymer or hydrophilic particles, and, if necessary, the surface may be treated by etching, plasma treatment, or the like.

[0065]

[0066] The above substrate (100) can be adhered to the skin through the adhesive portion (200), and the adhesive portion (200) can maintain a channel portion (300) of a certain space between the substrate (100) and the skin (10).

[0067] That is, it may be in the form of a film or sheet processed to have a shape including a capturing portion (310), a moving channel (320), a measuring portion (330), and a discharge portion (340) of a channel portion (300) described later, and may be coated with an adhesive to have the above shape.

[0068] The above adhesive portion (200) may have an appropriate adhesive strength to enable long-term attachment and easy detachment, and may have an adhesive strength that does not irritate the skin. For example, a conventional or later-developed adhesive or adhesive film may be used.

[0069] The adhesive may be, in one or more embodiments, an acrylic adhesive, a rubber adhesive, a silicone adhesive, a urethane adhesive, a polyvinyl alcohol adhesive, a polyvinyl pyrrolidone adhesive, a polyacrylamide adhesive, a cellulose adhesive, a vinyl alkyl ether adhesive, or the like. The adhesive is not particularly limited as long as it has adhesive strength and viscoelasticity, but is preferably an acrylic adhesive in terms of ease of acquisition, etc. For example, it may include a (meth)acrylate copolymer, a crosslinking agent, a solvent, etc.

[0070] The crosslinking agent may be a crosslinking agent that has been developed previously or will be developed later. For example, it may include a polyisocyanate compound, an epoxy resin, a melamine resin, a urea resin, a dialdehyde, a methylol polymer, etc., and preferably, it may include a polyisocyanate compound.

[0071] The above solvent may include a typical solvent used in the field of resin compositions. For example, solvents such as alcohol compounds such as methanol, ethanol, isopropanol, butanol, and propylene glycol methoxy alcohol; ketone compounds such as methyl ethyl ketone, methyl butyl ketone, methyl isobutyl ketone, diethyl ketone, and dipropyl ketone; acetate compounds such as methyl acetate, ethyl acetate, butyl acetate, and propylene glycol methoxy acetate; cellosolve compounds such as methyl cellosolve, ethyl cellosolve, and propyl cellosolve; and hydrocarbon compounds such as hexane, heptane, benzene, toluene, and xylene may be used. These solvents may be used alone or in combination of two or more.

[0072] The thickness of the adhesive portion (200) may be appropriately determined depending on the type of resin that acts as the adhesive, the adhesive strength, the environment in which the adhesive is used, etc. In one embodiment, the adhesive portion (200) may have a thickness of 10 to 300 μm, preferably 50 to 150 μm, so as to secure sufficient adhesive strength and maintain a predetermined distance so that the sensor portion (30) located at the measuring portion (330) does not come into contact with the skin.

[0073]

[0074] The above channel portion (300) is formed between the portion of the substrate (100) where the adhesive portion (200) is not formed and the user's skin (10), and a space can be formed and maintained with a predetermined gap between the substrate (100) and the skin (10) by the adhesive portion (200).

[0075] The above channel section (300) serves to move the sample so that it can be discharged after measuring the components of the captured sample, and includes a capturing section (310), a moving channel (320), a measuring section (330), and a discharge section (340).

[0076] The above-described collecting unit (310) can collect body fluid discharged from the skin, and in one embodiment, can have a shape having a relatively wide range to facilitate collection of body fluid. Specifically, the width of the collecting unit (310) is not particularly limited, but may have a diameter that is wider than the width of the moving channel (320). The shape of the collecting unit (310) is not particularly limited as long as it facilitates collection of body fluid, but may be a circular, oval, semicircular, or polygonal shape.

[0077] The above-mentioned capturing unit (310) may be formed on one side of the biosensor, as shown in FIGS. 1 and 2, and may include a plurality of capturing units, as shown in FIGS. 3 and 4, to enable capturing as many parts of the sample as possible.

[0078] The above-described plurality of capturing units can be connected to the moving channel (320) through a passage, and the capturing units can be connected to each other through the passage and connected to the moving channel (320).

[0079] The above-mentioned movement channel (320) may be provided as a passage through which the body fluid captured in the capturing unit (310) moves, and may be provided as a passage through which the sample is transferred to the measuring unit (330) through the movement channel (320) and the sample after measurement is discharged to the discharge unit (340). The movement channel (320) is formed through a space between the substrate (100) and the skin (10), and may have a shape having a width that gradually decreases from the capturing unit (310) side to the discharge unit (340) side.

[0080] Through a moving channel (320) of this shape, a fluid sample moves from a wide space to a narrow space. That is, the fluid sample moves due to the attractive force between the particles that compose it, and moves due to the difference between the intermolecular attractive force acting between particles located on the surface of the fluid and the intermolecular attractive force acting between particles located inside the fluid.

[0081]

[0082] The above measurement unit (330) is a space where the sensor unit (30) that analyzes the sample is located. The sensor unit (30) is installed on the substrate (100) at the location of the measurement unit (300), and for this purpose, the corresponding portion of the substrate may be formed hollow.

[0083] The above sensor unit (30) can directly come into contact with a sample passing through the measuring unit (300), and can detect components in the sample, and may include at least one sensor selected from the group consisting of a blood sugar sensor that detects glucose, a lactate sensor that detects lactate, an alcohol sensor that detects ethanol, and an electrolyte sensor that detects sodium ions, potassium ions, magnesium ions, and calcium ions.

[0084] The above sensor unit (30) is detachable from the substrate (100) and can be detached for replacement or cleaning, etc., as needed.

[0085] The above sensor part (30) is installed on the substrate (100) and is formed at a predetermined distance from the user's skin (10) through the adhesive part (200), so there is no concern that the sensor will be damaged due to contact.

[0086]

[0087] Meanwhile, as shown in FIGS. 3 to 5, a support (400) processed to have a shape including a capture portion (310), a moving channel (320), a measuring portion (330), and a discharge portion (340) of a channel portion (300) may be further included between the substrate (100) and the adhesive portion (200).

[0088] In this case, the channel portion (300) of the present invention may be formed between the portion of the substrate (100) where the support (400) and the adhesive portion (200) are not formed and the user's skin, and since it is easier to form and maintain a space with a predetermined gap between the substrate (100) and the skin (10) by the support (400) and the adhesive portion (200), the flow of the captured sample may be smoother.

[0089] That is, the positions corresponding to the capture portion (310), the moving channel (320), the measuring portion (330) and the discharge portion (340) of the adhesive portion (200) and the support (400) can overlap, and accordingly, the space forming the channel portion (300) becomes the thickness of the combined thickness of the adhesive portion (200) and the support (400), so that a predetermined gap can be further secured between the sensor portion (30) and the user's skin (10).

[0090] The above support (400) is selected from the group consisting of: polyester resins such as silicone, glass, glass epoxy, ceramic, polyethylene naphthalate (PET), and polybutylene terephthalate; cellulose resins such as diacetyl cellulose and triacetyl cellulose; polycarbonate resins; acrylic resins such as polymethyl (meth)acrylate and polyethyl (meth)acrylate; styrene resins such as polystyrene and acrylonitrile-styrene copolymers; polyolefin resins such as polyethylene, polypropylene, polyolefins having a cyclo- or norbornene structure, and ethylene-propylene copolymers; vinyl chloride resins; amide resins such as nylon and aromatic polyamides; imide resins; polyethersulfone resins; sulfone resins; polyether ether ketone resins; sulfated polyphenylene resins; vinyl alcohol resins; vinylidene chloride resins; vinyl butyral resins; It may be a film composed of a thermoplastic resin such as an allylate resin, a polyoxymethylene resin, an epoxy resin, etc., and a film composed of a blend of the above thermoplastic resins may also be used. In addition, a film composed of a thermosetting resin such as a (meth)acrylic resin, a urethane resin, an acrylic urethane resin, an epoxy resin, a silicone resin, or an ultraviolet-curable resin may be used, but is not limited thereto.

[0091] The thickness of the above support (400) is not particularly limited, but generally, considering workability such as strength and handleability, thin layer property, etc., it may be 10 to 300 μm, and preferably 50 to 200 μm.

[0092] As a method for fixing the support (400) to the substrate (100), a known attachment or bonding method may be applied. For example, the support (400) may be fixed by forming a perforated hole (not shown) in the support (400) and forming a protrusion (not shown) in the substrate (100) to bond the perforated hole and the protrusion, but the present invention is not limited thereto.

[0093]

[0094] The above substrate (100) and support (400) can be manufactured by cutting through laser processing as needed to have a shape as shown in FIGS. 1 to 4, and the laser may be a CO2 Laser, UV Laser, Pico Laser, etc., and may use Rep / Rate 50KHZ, Duty 5%, Power 1.64W 2Pass, etc., but is not limited thereto.

[0095]

[0096] Hereinafter, specific embodiments of the present invention will be described. However, the present invention is not limited to the embodiments disclosed below and may be implemented in various different forms. These embodiments are provided solely to ensure that the disclosure of the present invention is complete and to fully inform those skilled in the art of the invention of the scope of the invention. The present invention is defined solely by the scope of the claims.

[0097]

[0098] <Examples and Comparative Examples>

[0099] Example 1

[0100] A biosensor of Example 1 having the same structure as the biosensor illustrated in Fig. 1 was manufactured as follows.

[0101] A substrate (100) of 200㎛ thick PET (manufactured by Huvis) was prepared, and the substrate (100) was processed into the shape of Fig. 1 using a laser (UV pico laser), and a hydrophilic surface treatment was performed by coating with titanium oxide.

[0102] After cutting the adhesive (8146-4, 3M, thickness 100㎛) (200) including the heteromorphic film by laser processing to have a pattern as shown in Fig. 1,

[0103] A channel portion was formed by peeling off the release film on one side of the adhesive (200) and attaching it to the surface-treated side of the substrate (100).

[0104]

[0105] Example 2

[0106] In the above Example 1, a biosensor was manufactured in the same manner as in Example 6, except that the adhesive (8146-4, 3M, thickness 100 μm) (200) including the release film was laser processed to form a pattern as shown in FIG. 3 and cut to form a pattern.

[0107] A substrate (100) of 200 ㎛ thick PET (manufactured by Huvis) was prepared (1 in Fig. 6)), and the substrate (100) was processed into the shape of Fig. 3 using a laser (UV pico laser), and a hydrophilic surface treatment was performed by coating with titanium oxide. (2 in Fig. 6))

[0108] An adhesive (8146-4, 3M, 100 ㎛ thick) (200) including a release film was cut by laser processing to have a pattern as shown in Fig. 3 (3 in Fig. 6), and then the release film on one side of the adhesive (200) was peeled off and attached to the surface-treated side of the substrate (100), thereby forming a channel portion. (4 in Fig. 6))

[0109]

[0110] Example 3

[0111] In the above Example 2, a biosensor including a support (400) was manufactured as shown in FIG. 3.

[0112] PET (manufactured by Huvis) with a thickness of 150 μm was prepared as the support, and processed using a laser (UV pico laser) into the shape of Fig. 3.

[0113] An adhesive (8146-4, 3M, thickness 100 ㎛) (200) including a release film was cut by laser processing to have a pattern as shown in FIG. 3, and then the release film on one side of the adhesive (200) was peeled off and attached to the support.

[0114] The support (400) to which the adhesive (200) is attached is manufactured so that a perforated hole is formed at a position so that it can be attached to a protrusion (not shown) of the substrate, and a channel portion is formed by attaching the perforated hole to the protrusion formed on the surface-treated surface of the substrate.

[0115]

[0116] <Experimental Example>

[0117] The experimental results of sequentially introducing each of the above samples into the biosensor according to Examples 1 and 2 and the discharged results are shown in Figs. 7a and 7b, respectively.

[0118] Specifically, in the biosensor according to the above Examples 1 and 2, a red dye (Super Red, AmeriColor corp.) was first added (1) in Fig. 7a and 1) in 7b), and then a dilution solution (PBS) was added secondly to dilute it (2) in Fig. 7a and 2) in 7b). Subsequently, a blue dye (Navy Blue, AmeriColor corp.) was added thirdly (3) in Fig. 7a and 3) in 7b), and fourthly, the red dye (4) in 7b) was added again.

[0119] As can be seen in Figs. 7a and 7b, the biosensors of Examples 1 and 2 having the structure of the present invention were successively injected with different dyes into the capturing portion three or four times, and as a result, as the number of times the dye was injected increased, it was confirmed that the dye was discharged more smoothly and the color of the dye injected throughout the capturing portion, the moving channel, and the discharge portion changed evenly.

[0120]

[0121] A biosensor according to one embodiment of the present invention enables continuous measurement of a sample by allowing smooth movement of a captured sample from a capture portion to a discharge portion without damage to the sensor.

Claims

1. In a biosensor attached to the user's skin, substrate; an adhesive portion that comes into contact with the user's skin; and It includes a channel formed between the substrate and the user's skin, The above channel section, A collection unit that collects the sample in a liquid phase; A moving channel for moving a sample captured by the above capturing unit; A measuring unit having a sensor unit for measuring the concentration of a measurement target from the captured sample; and Including a discharge section through which the measured sample is discharged, The above sensor part is a biosensor formed at a predetermined distance from the user's skin.

2. In claim 1, A biosensor wherein the surface of the substrate forming the channel portion is hydrophilic.

3. In claim 1, A biosensor, wherein the adhesive portion comprises at least one selected from the group consisting of an acrylic adhesive, a rubber adhesive, a silicone adhesive, a urethane adhesive, a polyvinyl alcohol adhesive, a polyvinyl pyrrolidone adhesive, a polyacrylamide adhesive, a cellulose adhesive, and a vinyl alkyl ether adhesive.

4. In claim 1, A biosensor wherein the above channel portion is formed between a portion of the substrate where no adhesive portion is formed and the user's skin.

5. In claim 1, A biosensor in which the above-mentioned moving channel connects the capturing section, the measuring section, and the discharge section, and has a shape in which the width gradually decreases from the capturing section side to the discharge section side.

6. In claim 1, A biosensor comprising a plurality of capturing units.

7. In claim 6, A biosensor, wherein the above plurality of capturing units are connected to a moving channel through a plurality of passages.

8. In claim 1, A biosensor further comprising a support having a shape including the capture portion, the movement channel, the measurement portion, and the discharge portion, between the substrate and the adhesive portion.

9. In claim 1, A biosensor wherein the above sensor portion is separable.

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