Nicotine composition pouch and preparation method therefor

Abstract

A nicotine composition pouch, comprising a nicotine composition and a non-woven pouch for encapsulating the nicotine composition, wherein the nicotine composition comprises nicotine, sugar alcohol, a pH regulator, a filler, purified water, an adhesive, a humectant, a flavoring agent and a dispersing agent. The nicotine composition pouch further comprises a coating solution used for increasing the humidity of the nicotine composition. The nicotine composition pouch has a humidity of 30-50%. Before encapsulation, the nicotine composition has a particle size of ≤ 500 microns, a humidity of 10-30%, and a Carr's index of a bulk density of ≤ 20%. In addition, a preparation method for the nicotine composition pouch is provided. The nicotine composition pouch has a high level of humidity, good fluidity and a low preparation cost, and the preparation method for the nicotine composition pouch is simple, which can reduce the cost of a preparation device. Moreover, the nicotine composition pouch has a small filling quantity deviation, is easy to operate, and has a uniform content.

Description

Nicotine composition pouch and preparation method thereof Technical Field

[0001] The present invention relates to the technical field of nicotine, and in particular to a nicotine composition pouch and a preparation method thereof. Background Art

[0002] The World Health Organization considers smokeless products to be less harmful than regular cigarettes and an ideal alternative. Nicotine pouches, a key category of smokeless tobacco, reduce the harmful substances produced by tobacco combustion or thermal decomposition. Furthermore, snus can be used in smoking-prohibited areas, such as indoors and on airplanes, satisfying consumers' physiological nicotine needs.

[0003] Currently, common snus are made from a mixture of granules or powders. Based on humidity, they can be categorized as low-humidity products (less than 10%), medium-humidity products (10%-30%), and high-humidity products (30%-50%). These products, particularly in Europe, account for over 70% of the market. High-humidity products offer a quick intoxication and a strong throat hit. However, due to the high moisture content, high-humidity products have poor fluidity during granule packaging. This results in excessively large packing volumes, uneven product content, and an inefficient packaging process, often leading to clogged feed pipes and low production efficiency.

[0004] Patent publication number CN114304712A describes a high-liquid-loaded nicotine oral product granule and its preparation method. The method uses highly viscous binders, starch, and sugar alcohols, along with nicotine, a humectant, fiber, purified water, preservatives, flavorings, salting agents, and pH adjusters, to create granules with a size of 0.35mm-1mm to enhance fluidity. The humidity level is maintained at above 40%. However, this method uses excessive amounts of highly viscous substances (such as propylene glycol, glycerol, starch, and gum arabic), and the granules are too large, which can easily lead to granule adhesion and poor fluidity.

[0005] Patent publication number EP4162927A1 describes a nicotine pouch composition comprising: a sugar alcohol comprising at least 10% by weight of the composition; water-insoluble fiber comprising at least 5-50% by weight of the composition; water comprising at least 15-65% by weight of the composition; and nicotine comprising 0.1-5% by weight of the composition. Furthermore, the composition has a bulk density of at most 0.8 g / kg, with the weight ratio of water to water-insoluble fiber not exceeding 3.0. This method maintains high humidity while ensuring a certain degree of fluidity, but does not specify particle size or bulk density, and requires the use of a nicotine-binding resin and specialized particle packaging equipment.

[0006] Existing high-humidity nicotine pouches typically use compressed air as a power source to address poor product flowability. This type of structure suffers from poor filling stability and can also cause loss of nicotine content due to air carryover. Furthermore, this type of equipment is typically single-row, resulting in low production capacity. This makes it difficult to achieve a balance between efficient production and product quality in high-humidity nicotine pouches.

[0007] Therefore, the existing technology needs to be improved. Summary of the Invention

[0008] Existing high-humidity nicotine pouches typically use expensive equipment to address the problem of poor product fluidity. This leads to a struggle to achieve a balance between efficient production and product quality. Therefore, the present invention provides a nicotine composition pouch and a method for preparing the same to address the aforementioned issues.

[0009] To achieve the above objectives, in a first aspect, the present invention provides a nicotine composition pouch, comprising a nicotine composition and a non-woven fabric pouch for encapsulating the nicotine composition, wherein the nicotine composition comprises nicotine, a sugar alcohol, a pH adjuster, a filler, purified water, a binder, a humectant, a flavoring agent, and a dispersant. The nicotine composition pouch further comprises a coating liquid for increasing the humidity of the nicotine composition, wherein the humidity of the nicotine composition pouch is 30-50%.

[0010] In one implementation, the coating liquid includes one or more combinations of purified water, flavoring agents, sweeteners, moisturizers, cooling agents, and nicotine.

[0011] In one implementation, the nicotine composition comprises the following raw materials in parts by weight: 1-20 parts of nicotine, 5-20 parts of sugar alcohol, 1-10 parts of pH adjuster, 20-60 parts of filler, 5-30 parts of purified water, 1-5 parts of binder, 1-8 parts of humectant, 2-10 parts of flavoring agent, and 1-10 parts of dispersant.

[0012] In one implementation, the particle size of the nicotine composition before packaging is ≤500 μm, the humidity is 10%-30%, and the Carr index of the bulk density is ≤20%.

[0013] In one implementation, the nicotine includes any one or a combination of synthetic nicotine, natural nicotine, nicotine free base, a nicotine-ion exchange resin combination, a nicotine inclusion complex, and non-covalently bound nicotine; the nicotine-ion exchange resin combination includes any one or a combination of nicotine lactate, nicotine malate, nicotine salicylate, a nicotine resin complex, a nicotine cyclodextrin inclusion complex, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, and nicotine benzoate.

[0014] In one implementation, the sugar alcohol is a polyol containing two or more hydroxyl groups used as any one of a thickener, a binder, a sweetener and a stabilizer, and the polyol includes any one of propylene glycol, xylitol, maltitol, mannitol, erythritol, isomalt and lactitol, or a combination thereof.

[0015] In one implementation, the pH adjuster includes one or a combination of sodium carbonate, sodium bicarbonate, potassium carbonate, magnesium carbonate, potassium bicarbonate, tromethamine, and phosphate buffer.

[0016] In one implementation, the filler is at least one water-insoluble fiber, and the water-insoluble fiber includes one or a combination of wheat fiber, pea fiber, rice fiber, corn fiber, oat fiber, tomato fiber, barley fiber, rye fiber, beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, cellulose fiber, bran fiber, bamboo fiber, pandan fiber, powdered cellulose and microcrystalline cellulose, and the water-insoluble fiber has a water binding capacity of 200% or more.

[0017] In one embodiment, the adhesive includes one or a combination of natural plant glue, animal glue, polyvinyl alcohol, polyvinyl pyrrolidone, cellulose derivatives, povidone, sodium alginate and gum arabic, and the cellulose derivative includes one or a combination of microcrystalline cellulose, microcrystalline cellulose / sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and methyl cellulose.

[0018] In one embodiment, the humectant comprises one or a combination of 1,2-propylene glycol, glycerol, honey, glucose syrup and maltitol sugar.

[0019] In one implementation, the flavoring agent includes one or a combination of bergamot flavor, eucalyptus flavor, citrus flavor, lemon flavor, peppermint flavor, mint flavor, menthol, licorice flavor, wintergreen flavor, tobacco flavor, coffee flavor, vanilla flavor, lime flavor, apple flavor, peach flavor, mango flavor, cherry flavor, blueberry flavor, strawberry flavor, cola flavor, cinnamon flavor, pandan flavor and watermelon flavor.

[0020] In one embodiment, the dispersant is a surfactant having lipophilicity and / or hydrophilicity in the molecule, and the dispersant includes any one of fatty acids, fatty amides, esters, paraffins, metal soaps and low molecular weight waxes, the esters include any one of stearamide, vinyl bisstearamide, stearic acid monoglyceride, tristearic acid glyceride and medium-chain fatty acids; the paraffins include any one of paraffin, liquid paraffin and microcrystalline paraffin; the metal soaps include any one of barium stearate, zinc stearate, calcium stearate, cadmium stearate, magnesium stearate and copper stearate; the low molecular weight waxes include any one of homopolymers, oxidized homopolymers, ethylene-acrylic acid copolymers, ethylene-vinyl acetate copolymers, low molecular weight ionomers, polyethylene wax, oxidized polyethylene wax and polyethylene glycol.

[0021] In one implementation, the sweetener is an artificially synthesized and / or naturally extracted sweetener, and the sweetener includes one or a combination of aspartame, acesulfame potassium, cyclamate, saccharin, saccharin sodium, sucralose, neotame, sodium cyclamate, aspartame, alitame, stevioside, licorice, disodium glycyrrhizate, tripotassium and trisodium glycyrrhizate, glucose, fructose, sucrose, maltose, starch sugar and lactose, sorbitol, maltitol, isomalt, palatinol, xylitol, lactitol, mannitol, erythritol and dextran.

[0022] In one embodiment, the cooling agent includes menthol, WS-3, WS-23, WS-12, WS-5, WS-14, menthone glycerol acetal, 3-(L-menthoxy)-2-methyl-1,2-propanediol, 3-(1-methoxy)-2-methyl-1,2-propanediol, cis- and trans-p-menthyl-3,8-diol, 2,3-dihydroxymentane, 3,3,5-trimethylcyclohexanone glycerol acetal, One or a combination of the following: ketone, (1R,3R,4S)-3-menthyl 3,6-oxaheptanoate, (1R,2S,5R)-menthyl methoxyacetate, (1R,2S,5R)-3-menthyl 3,6,9-trioxadecanoate, (1R,2S,5R)-3-menthyl (2-hydroxyethoxy)acetate, and (1R,2S,5R)-menthyl 11-hydroxy-3,6,9-trioxaundecanoate.

[0023] In one implementation, the nicotine composition may further include a preservative, which includes one or a combination of sorbic acid and its salts, dehydroacetic acid and its sodium salts, parabens, sodium diacetate, calcium propionate, and sodium / calcium lactate.

[0024] In a second aspect, the present invention further provides a method for preparing a nicotine composition pouch, comprising the following specific steps:

[0025] S1. Granulating the nicotine composition according to the above formula to obtain a nicotine composition having a particle size of ≤500 μm, a humidity of 10%-30%, and a bulk density Carr index of ≤20%;

[0026] S2. putting the nicotine composition into the non-woven fabric pouch;

[0027] S3. According to the above-mentioned coating solution formula, the purified water, flavoring agent, sweetener, moisturizer, cooling agent and nicotine are mixed to prepare a coating solution;

[0028] S4. Adding the non-woven fabric pouch containing the nicotine composition particles into a coating machine, and after spraying the coating liquid, obtaining the nicotine composition pouch with a humidity of 30-50%.

[0029] In one implementation, S1 specifically includes: first taking solid powders of nicotine, sugar alcohol, pH adjuster and filler and adding them to a double cone mixer for premixing, mixing for 5-10 minutes at a speed of 6 rpm, and filling into barrels after mixing is completed; adding the obtained material to a wet granulator for granulation, turning on the stirring paddle and stirring at a speed of 100-200 rpm, stirring for 3-5 minutes, and then turning on the spraying mode; at the same time, purified water, binder, moisturizer, flavoring agent and dispersant are weighed and added to a slurry preparation tank for preparation, wherein the stirring speed is 100-1500 rpm and the stirring time is 10-30 minutes, the materials are added to the wet granulator through a pump, the filling is completed within 3-8 minutes, the granulation mode is turned on, stirring for 5-10 minutes, stopping the machine and removing the materials; the obtained materials are placed in a granule packaging machine for granule packaging, and the granule machine speed is set to 120 granules / minute to obtain the nicotine composition.

[0030] In one implementation, S4 specifically includes: adding the non-woven fabric pouch containing the nicotine composition particles into a coating machine, setting the coating machine speed to 5-10 rpm and the spraying flow rate to 5-60 rpm; after spraying the coating liquid, the coating machine continues to rotate for 5-30 minutes to obtain the nicotine composition pouch.

[0031] Beneficial effects: The nicotine composition pouch provided by the present invention and the preparation method thereof, wherein nicotine salt or nicotine-binding resin is uniformly dispersed in a solid by the dispersant to form a nicotine composition, so that the nicotine composition can be loaded into a non-woven fabric pouch by a conventional granule packaging machine. The preparation method is simple, reduces the cost of the preparation equipment, and has small deviation in loading amount, simple operation, and uniform content. Flavoring agents, sweeteners, cooling agents, nicotine, and other ingredients can be added to the coating liquid used for humidification as required, thereby enhancing the flavor of the product while ensuring the humidity. In the preparation method, the coating machine can accurately control the humidification amount of each pouch, and can also add fragrance, sweetness, and cooling, thereby resolving the contradiction between efficient production and product quality, and providing a nicotine composition pouch with high humidity, good fluidity, stable loading amount, uniform content, and low preparation cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] FIG1 is a flow chart of the steps of the method for preparing a nicotine composition pouch provided by the present invention;

[0033] The purpose, features and advantages of the present invention will be further described with reference to the accompanying drawings and in conjunction with the embodiments. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical solutions and advantages of the present invention more clear, the present invention is further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. In addition, the descriptions of the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" described below mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the technical features involved in the various embodiments of the present invention can be combined with each other as long as they do not conflict with each other.

[0035] The present invention provides a nicotine composition pouch, comprising a nicotine composition and a non-woven fabric pouch for encapsulating the nicotine composition. The nicotine composition comprises nicotine, a sugar alcohol, a pH adjuster, a filler, purified water, a binder, a humectant, a flavoring agent, and a dispersant. The nicotine composition pouch also comprises a coating solution for increasing the humidity of the nicotine composition, wherein the humidity of the nicotine composition pouch is 30-50%. The coating solution comprises one or more combinations of purified water, a flavoring agent, a sweetener, a humectant, a cooling agent, and nicotine. The nicotine composition, before encapsulation, has a particle size of ≤500 microns, a humidity of 10%-30%, and a Carr's index of bulk density of ≤20%.

[0036] Specifically, the nicotine composition comprises the following raw materials in parts by weight: 1-20 parts of nicotine, 5-20 parts of sugar alcohol, 1-10 parts of pH adjuster, 20-60 parts of filler, 5-30 parts of purified water, 1-5 parts of binder, 1-8 parts of humectant, 2-10 parts of flavoring agent and 1-10 parts of dispersant.

[0037] Specifically, the nicotine includes any one or a combination of synthetic nicotine, natural nicotine, nicotine free base, nicotine-ion exchange resin combination, nicotine inclusion complex and non-covalently bound nicotine, and the nicotine-ion exchange resin combination includes any one or a combination of nicotine lactate, nicotine malate, nicotine salicylate, nicotine resin complex, nicotine cyclodextrin embedding complex, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride and nicotine benzoate.

[0038] Specifically, the sugar alcohol is a polyol containing two or more hydroxyl groups used as any one of a thickener, a binder, a sweetener and a stabilizer, and the polyol includes any one of propylene glycol, xylitol, maltitol, mannitol, erythritol, isomalt and lactitol or a combination thereof.

[0039] Specifically, the pH regulator includes one or a combination of sodium carbonate, sodium bicarbonate, potassium carbonate, magnesium carbonate, potassium bicarbonate, tromethamine and phosphate buffer.

[0040] Specifically, the filler is at least one water-insoluble fiber, and the water-insoluble fiber includes one or a combination of wheat fiber, pea fiber, rice fiber, corn fiber, oat fiber, tomato fiber, barley fiber, rye fiber, beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, cellulose fiber, bran fiber, bamboo fiber, pandan fiber, powdered cellulose and microcrystalline cellulose, and the water-insoluble fiber has a water binding capacity of 200% or more.

[0041] Specifically, the adhesive includes one or a combination of natural plant glue, animal glue, polyvinyl alcohol, polyvinyl pyrrolidone, cellulose derivatives, povidone, sodium alginate and gum arabic, and the cellulose derivative includes one or a combination of microcrystalline cellulose, microcrystalline cellulose / sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and methyl cellulose.

[0042] Specifically, the moisturizing agent includes one or a combination of 1,2-propylene glycol, glycerol, honey, glucose syrup and maltitol sugar.

[0043] Specifically, the flavoring agent includes one or a combination of bergamot flavor, eucalyptus flavor, citrus flavor, lemon flavor, peppermint flavor, mint flavor, menthol, licorice flavor, wintergreen flavor, tobacco flavor, coffee flavor, vanilla flavor, lime flavor, apple flavor, peach flavor, mango flavor, cherry flavor, blueberry flavor, strawberry flavor, cola flavor, cinnamon flavor, pandan flavor and watermelon flavor.

[0044] Specifically, the dispersant is a surfactant having lipophilicity and / or hydrophilicity in the molecule, and the dispersant includes any one of fatty acids, aliphatic amides, esters, paraffins, metal soaps and low molecular weight waxes, the esters include any one of stearamide, vinyl bisstearamide, stearic acid monoglyceride, tristearic acid glyceride and medium-chain fatty acids; the paraffins include any one of paraffin, liquid paraffin and microcrystalline paraffin; the metal soaps include any one of barium stearate, zinc stearate, calcium stearate, cadmium stearate, magnesium stearate and copper stearate; the low molecular weight waxes include any one of homopolymers, oxidized homopolymers, ethylene-acrylic acid copolymers, ethylene-vinyl acetate copolymers, low molecular weight ionomers, polyethylene wax, oxidized polyethylene wax and polyethylene glycol.

[0045] Specifically, the sweetener is a sweetening substance artificially synthesized and / or naturally extracted, and the sweetener includes one or a combination of aspartame, acesulfame potassium, cyclamate, saccharin, saccharin sodium, sucralose, neotame, sodium cyclamate, aspartame, alitame, stevioside, licorice, disodium glycyrrhizate, tripotassium and trisodium glycyrrhizate, glucose, fructose, sucrose, maltose, starch sugar and lactose, sorbitol, maltitol, isomalt, palatinol, xylitol, lactitol, mannitol, erythritol and dextran.

[0046] Specifically, the cooling agent includes menthol, WS-3, WS-23, WS-12, WS-5, WS-14, menthone glycerol acetal, (3-(L-menthoxy)-2-methyl-1,2-propanediol, 3-(1-methoxy)-2-methyl-1,2-propanediol, cis- and trans-p-menthyl-3,8-diol, 2,3-dihydroxymentane, 3,3,5-trimethylcyclohexanone glycerol acetal, One or a combination of (1R,3R,4S)-3-mentheptyl 3,6-oxaneheptanoate, (1R,2S,5R)-menthyl methoxyacetate, (1R,2S,5R)-3-menthyl 3,6,9-trioxadecanoate, (1R,2S,5R)-3-menthyl (2-hydroxyethoxy)acetate, and (1R,2S,5R)-menthyl 11-hydroxy-3,6,9-trioxaundecanoate.

[0047] Specifically, the nicotine composition may further include a preservative, which includes one or a combination of sorbic acid and its salts, dehydroacetic acid and its sodium salts, parabens, sodium diacetate, calcium propionate, and sodium / calcium lactate.

[0048] 1 , the present invention further provides a method for preparing a nicotine composition pouch, which comprises the following specific steps:

[0049] S1. Granulating the nicotine composition according to the formula of the present invention to obtain a nicotine composition having a particle size of ≤500 μm, a moisture content of 10%-30%, and a Carr's index of bulk density ≤20%;

[0050] S2. putting the nicotine composition into the non-woven fabric pouch;

[0051] S3. According to the formula of the coating solution of the present invention, the purified water, flavoring agent, sweetener, moisturizing agent, cooling agent and nicotine are mixed to form a coating solution;

[0052] S4. Adding the non-woven fabric pouch containing the nicotine composition particles into a coating machine, and after spraying the coating liquid, obtaining the nicotine composition pouch with a humidity of 30-50%.

[0053] Specifically, in S1, the steps include: first taking solid powders of nicotine, sugar alcohol, pH adjuster and filler and adding them to a double cone mixer for premixing, mixing for 5-10 minutes at a speed of 6 rpm, and then barreling after mixing; adding the resulting material to a wet granulator for granulation, turning on a stirring paddle and stirring at a speed of 100-200 rpm, stirring for 3-5 minutes, and then turning on a spraying mode; simultaneously, weighing purified water, a binder, a moisturizer, a flavoring agent and a dispersant and adding them to a slurry preparation tank for preparation, wherein the stirring speed is 100-1500 rpm and the stirring time is 10-30 minutes, adding the material to the wet granulator through a pump, completing the filling within 3-8 minutes, turning on a granulation mode, stirring for 5-10 minutes, stopping the machine and removing the material; and placing the resulting material into a granule packaging machine for granule packaging, with the granule machine speed set to 120 granules / minute, to obtain the nicotine composition.

[0054] Specifically, S4 includes: adding the non-woven fabric pouch containing the nicotine composition particles into a coating machine, setting the coating machine speed to 5-10 rpm and the spraying flow rate to 5-60 rpm. After the coating liquid is sprayed, the coating machine is further rotated for 5-30 minutes to obtain the nicotine composition pouch.

[0055] This invention uses a secondary humidification process to address the needs of high-humidity products. The moisture content of the first process is controlled between 10% and 30%. A conventional 16-row screw filling machine can be used for filling, achieving high output and stable metering.

[0056] The present invention provides the following examples to illustrate the technical solutions of the present invention.

[0057] Example 1: Preparation of a nicotine composition pouch with a humidity of 37%.

[0058] Weigh the required materials according to the formula in Table 1.

[0059]

[0060] Table 1. Nicotine composition formulation in Example 1

[0061] The materials of Table 1 were prepared as follows:

[0062] S11. Add solid powders such as nicotine salt, microcrystalline cellulose, sodium chloride, xylitol, pH adjuster, and preservative according to the formula and pre-mix them in a double-cone mixer. Mix for 5 minutes at 6 rpm. After mixing, pack into barrels.

[0063] S12. According to the formula, the purified water, medium-chain fatty acids, sodium alginate, essence, propylene glycol, glycerin and other materials are weighed and added into the slurry mixing tank for preparation. The stirring speed is 120 rpm and the stirring time is 10 minutes.

[0064] S13: Add the material obtained in S11 to the wet granulator and start stirring at 100 rpm. After stirring for 3 minutes, start the spraying mode and add the material obtained in S12 to the wet granulator via a pump. Complete the addition within 3 minutes, then start the granulation process and stir for 5 minutes. Stop the machine, remove the material, and obtain the nicotine composition.

[0065] S14: The nicotine composition from S13 is placed in a granule packaging machine for granule packaging. The granule packaging machine is set to a filling speed of 120 granules / minute. After granule packaging, the nicotine composition pouches are formed. The nicotine composition is inspected before proceeding to the next step: coating.

[0066] The test results of the obtained nicotine composition are shown in Table 2.

[0067]

[0068] Table 2. Test results of the nicotine composition prepared according to the formula of Example 1

[0069] S15: Prepare a coating solution: Weigh purified water to 22% of the total weight of the nicotine composition. Add the nicotine composition pouches to the coating machine, setting the machine speed to 5 rpm. After the coating solution is added, rotate for another 10 minutes to obtain a high-humidity product. The high-humidity nicotine composition pouches were tested. The results are shown in Table 3.

[0070]

[0071] Table 3 Test results of high humidity nicotine composition pouches in Example 1

[0072] As can be seen from Example 1, the Carr's index of the nicotine composition before humidification was less than 15%, indicating excellent fluidity. Furthermore, 90% of the particles had a particle size of ≤380 microns at a humidity of 15%. During granule packaging, there was no pipe blockage, and material discharge was smooth. After packaging, the total amount tested met the standard. Subsequently, the nicotine composition pouches were coated and humidified. After adding 22% moisture, the weight of the contents increased by approximately 20%, and the humidity reached 37%. Simultaneously, the Carr's index increased to 22%, and the particle size increased, but the nicotine content remained unchanged. This indicates that the increase in moisture, coupled with the change in humidity, causes both the Carr's index and the particle size to increase. This is because the increased humidity increases the viscosity of the particles, which deteriorates their fluidity. Example 1 demonstrates that the present invention can effectively address the problem of high-humidity product granule packaging.

[0073] Example 2: Preparation of a nicotine composition pouch with a humidity of 45%.

[0074] Weigh the required materials according to the formula in Table 4.

[0075]

[0076] Table 4 Nicotine composition formula in Example 2

[0077] The materials of Table 4 were prepared as follows:

[0078] S21: Add solid powders such as nicotine salt, microcrystalline cellulose, sodium chloride, xylitol, pH adjuster, and preservative according to the formula into a double cone mixer for premixing. Mix for 5 minutes at a speed of 6 rpm. After mixing, the mixture is loaded into barrels.

[0079] S22: Weigh purified water, medium-chain fatty acids, sodium alginate, flavoring, propylene glycol, glycerin, and other ingredients according to the recipe and add them to the slurry mixing tank for preparation. Stir at 120 rpm for 10 minutes.

[0080] S23: Add the material obtained in S21 to the wet granulator and start stirring at 100 rpm. After stirring for 3 minutes, start the spraying mode and add the material obtained in S22 to the wet granulator via a pump. Complete the addition within 3 minutes, then start the granulation process and stir for 5 minutes. Stop the machine, remove the material, and obtain the nicotine composition.

[0081] S24: The nicotine composition from S23 is placed in a granule packaging machine for granule packaging. The granule packaging machine is set to a filling speed of 120 granules / minute. After granule packaging, the nicotine composition pouches are formed. The nicotine composition is inspected before proceeding to the next step: coating.

[0082] The test results of nicotine composition are shown in Table 5.

[0083]

[0084] Table 5. Test results of the nicotine composition prepared according to the formula of Example 2

[0085] S25: Prepare the coating solution: Weigh purified water to 25% of the total weight of the nicotine composition to form a coating solution. Add the nicotine composition pouch to the coating machine, setting the machine speed to 5 rpm. After the coating solution is added, rotate for another 10 minutes to obtain a high-humidity product. The high-humidity nicotine composition pouches were tested. The results are shown in Table 6.

[0086]

[0087] Table 6. Test results of high humidity nicotine composition pouches in Example 2

[0088] As can be seen from Example 2, the Carr's index of the nicotine composition before humidification was less than 15%, indicating excellent fluidity. Furthermore, 90% of the particles had a particle size of ≤425 microns at a humidity of 20%. During granule packaging, there was no pipe blockage, and material discharge was smooth. After packaging, the total amount tested met the standard. Subsequently, the nicotine composition pouches were coated and humidified. After adding 25% moisture, the weight of the contents increased by approximately 25%, reaching a humidity of 45%. The Carr's index increased to 27%, and the particle size increased, but the nicotine content remained unchanged. This indicates that the increase in moisture, coupled with the change in humidity, causes both the Carr's index and the particle size to increase. This is because the increased viscosity of the particles after the humidity increases, which deteriorates the fluidity of the particles. Example 2 demonstrates that even at a high humidity of 45%, the present invention can effectively address the problem of high-humidity product granule packaging.

[0089] Example 3: Preparation of a nicotine composition pouch with a humidity of 50%.

[0090] Weigh the required materials according to the formula in Table 7.

[0091]

[0092] Table 7. Nicotine composition formulation in Example 3

[0093] The materials of Table 7 were prepared as follows:

[0094] S31: Add solid powders such as nicotine salt, microcrystalline cellulose, sodium chloride, xylitol, pH adjuster, and preservative according to the formula into a double cone mixer for premixing. Mix for 5 minutes at a speed of 6 rpm. After mixing, the mixture is loaded into barrels.

[0095] S32: Weigh purified water, medium-chain fatty acids, sodium alginate, flavoring, propylene glycol, glycerin, and other ingredients according to the recipe and add them to the slurry mixing tank for preparation. Stir at 120 rpm for 10 minutes.

[0096] S33: Add the material obtained in S31 to the wet granulator and start stirring at 100 rpm. After stirring for 3 minutes, start the spraying mode and pump the material obtained in S32 into the wet granulator. Complete the addition within 3 minutes. Simultaneously, start the granulation process and stir for 5 minutes. Stop the machine, remove the material, and obtain the nicotine composition.

[0097] S34: The nicotine composition from S33 is placed in a granule packaging machine for granule packaging. The granule packaging machine is set to a filling speed of 120 granules / minute. After granule packaging, the nicotine composition pouches are formed. The nicotine composition is inspected before proceeding to the next step: coating.

[0098] The test results of nicotine composition are shown in Table 8.

[0099]

[0100] Table 8. Test results of the nicotine composition prepared according to the formula of Example 3

[0101] S35: Prepare a coating solution: Weigh purified water to 25% of the total weight of the nicotine composition. Add the nicotine composition pouch to the coating machine, setting the machine speed to 5 rpm. After the coating solution is added, rotate for another 10 minutes to obtain a high-humidity product. The high-humidity nicotine composition pouches were tested. The results are shown in Table 9.

[0102]

[0103] Table 9. Test results of high humidity nicotine composition pouches in Example 3

[0104] As can be seen from Example 3, the Carr's index of the nicotine composition before humidification is 16%, indicating that the nicotine composition has good fluidity. Moreover, 90% of the particle diameters are all within 500 microns. At a humidity of 25%, pipe blocking rarely occurs during granule packaging, and blanking is still considered smooth. After packaging, the weight test meets the standard. Subsequently, the nicotine composition pouch is coated and humidified. After increasing the moisture by 25%, the weight of the contents increases by about 25%, and the humidity reaches 50%. The Carr's index increases to 39%, and the particle size becomes larger, but the nicotine content does not change. This indicates that the increase in moisture causes the humidity to change, causing the Carr's index and particle size to become larger. This is because the viscosity of the particles increases after the humidity increases, thereby deteriorating the fluidity of the particles. Example 3 illustrates that even under 50% high humidity, the present invention can well solve the problem of high-humidity product granule packaging.

[0105] Example 4: Stability study of 35% high humidity product

[0106] Table 10 shows the results of a 12-month stability study of batch 20210725 of high humidity nicotine composition pouches.

[0107]

[0108] Table 10. Summary of long-term stability experimental data of nicotine composition pouches (humidity 37%)

[0109] Batch number: 20210725

[0110] As can be seen from Example 4, the nicotine composition pouch obtained by the present invention can still maintain normal content and moisture after 12 months, meets the quality requirements, and has long-term stability.

[0111] In summary, the nicotine composition pouch and preparation method provided by the present invention utilizes the dispersant to uniformly disperse nicotine salt or nicotine-binding resin in a solid to form a nicotine composition, allowing the nicotine composition to be packaged into a non-woven fabric pouch using a conventional granule packaging machine. The preparation method is simple, reduces the cost of manufacturing equipment, and features minimal deviation in loading, simple operation, and uniform content. Flavoring agents, sweeteners, cooling agents, nicotine, and other ingredients can be added to the coating liquid used for humidification as required, thereby enhancing the flavor of the product while maintaining humidity. In the preparation method, the coating machine can precisely control the humidification amount for each pouch while also providing flavor, sweetening, and cooling properties. This resolves the conflict between efficient production and product quality, providing a nicotine composition pouch with high humidity, good fluidity, stable loading, uniform content, and low production cost.

[0112] The above description is only a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the present invention description and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A nicotine composition sachet, characterized in that, It includes a nicotine composition and a non-woven pouch for encapsulating the nicotine composition. The nicotine composition includes nicotine, sugar alcohol, pH regulator, filler, purified water, binder, humectant, flavoring agent and dispersant. The nicotine composition pouch further includes a coating solution for increasing the humidity of the nicotine composition, and the humidity of the nicotine composition pouch is 30% - 50%.

2. The nicotine composition sachet according to claim 1, characterized in that, The coating solution includes one or more combinations of purified water, flavoring agent, sweetening agent, humectant, cooling agent and nicotine.

3. The nicotine composition sachet according to claim 1, wherein The nicotine composition includes the following raw materials by weight: 1 - 20 parts of nicotine, 5 - 20 parts of sugar alcohol, 1 - 10 parts of pH regulator, 20 - 60 parts of filler, 5 - 30 parts of purified water, 1 - 5 parts of binder, 1 - 8 parts of humectant, 2 - 10 parts of flavoring agent and 1 - 10 parts of dispersant.

4. The nicotine composition sachet according to claim 1, wherein Before encapsulation, the particle size of the nicotine composition is ≤500 microns, the humidity is 10% - 30%, and the Carr index of the tapped density is ≤20%.

5. The nicotine composition sachet according to claim 1 or 2, characterized in that, The nicotine includes any one or a combination of synthetic nicotine, natural nicotine, nicotine free base, nicotine-ion exchange resin combination, nicotine inclusion complex and non-covalently bound nicotine. The nicotine-ion exchange resin combination includes any one or a combination of nicotine lactate, nicotine malate, nicotine salicylate, nicotine resin complex, nicotine cyclodextrin inclusion complex, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride and nicotine benzoate.

6. The nicotine composition sachet according to claim 1 or 2, characterized in that, The sugar alcohol is a polyhydric alcohol containing two or more hydroxyl groups used as any one of a thickening agent, binder, sweetening agent and stabilizer. The polyhydric alcohol includes any one or a combination of propylene glycol, xylitol, maltitol, mannitol, erythritol, isomaltulose and lactitol.

7. The nicotine composition sachet according to claim 1 or 2, characterized in that, The pH regulator includes one or a combination of sodium carbonate, sodium bicarbonate, potassium carbonate, magnesium carbonate, potassium bicarbonate, tromethamine and phosphate buffer solution.

8. The nicotine composition sachet according to claim 1 or 2, characterized in that, The filler is at least one water-insoluble fiber. The water-insoluble fiber includes any one or a combination of wheat fiber, pea fiber, rice fiber, corn fiber, oat fiber, tomato fiber, barley fiber, rye fiber, beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, cellulose fiber, bran fiber, bamboo fiber, vanillin fiber, powdered cellulose and microcrystalline cellulose. The water-insoluble fiber has a water-binding capacity of 200% or more.

9. The nicotine composition sachet according to claim 1 or 2, characterized in that, The binder includes one or a combination of natural plant gum, animal glue, polyvinyl alcohol, polyvinylpyrrolidone, cellulose derivative, povidone, sodium alginate and gum arabic. The cellulose derivative includes any one or a combination of microcrystalline cellulose, microcrystalline cellulose / sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose and methylcellulose.

10. The nicotine composition sachet according to claim 1 or 2, characterized in that, The humectant includes one or a combination of 1,2-propylene glycol, glycerol, honey, glucose syrup and maltitol sugar.

11. The nicotine composition sachet according to claim 1 or 2, characterized in that, The flavoring agent includes one or a combination of bergamot essence, eucalyptus essence, citrus essence, lemon essence, peppermint essence, mint essence, menthol, licorice essence, wintergreen essence, tobacco essence, coffee essence, vanilla essence, lime essence, apple essence, peach essence, mango essence, cherry essence, blueberry essence, strawberry essence, cola essence, cinnamon essence, vanillin essence, and watermelon essence.

12. The nicotine composition sachet according to claim 1 or 2, characterized in that, The dispersant is a surfactant having lipophilicity and / or hydrophilicity in the molecule. The dispersant includes any one of fatty acids, aliphatic amides, esters, paraffins, metal soaps, and low molecular weight waxes. The esters include any one of stearamide, vinyl bisstearamide, monoglyceryl stearate, tristearin, and medium-chain fatty acids; the paraffins include any one of paraffin, liquid paraffin, and microcrystalline wax; the metal soaps include any one of barium stearate, zinc stearate, calcium stearate, cadmium stearate, magnesium stearate, and copper stearate; the low molecular weight waxes include any one of homopolymers, oxidized homopolymers, ethylene-acrylic acid copolymers, ethylene-vinyl acetate copolymers, low molecular weight ionomers, polyethylene wax, oxidized polyethylene wax, and polyethylene glycol.

13. The nicotine composition sachet according to claim 1 or 2, characterized in that, The sweetener is a synthetic and / or natural extracted sweet substance. The sweetener includes one or a combination of aspartame, acesulfame potassium, sodium cyclamate, saccharin, sodium saccharin, sucralose, neotame, sodium cyclohexylsulfamate, alitame, stevioside, licorice, disodium glycyrrhizinate, tripotassium and trisodium glycyrrhizinate, glucose, fructose, sucrose, maltose, starch sugar, and lactose, sorbitol, maltitol, isomaltitol, palatinose, xylitol, lactitol, mannitol, erythritol, and dextran.

14. The nicotine composition sachet according to claim 1 or 2, characterized in that, The cooling agent includes one or a combination of menthol, WS-3, WS-23, WS-12, WS-5, WS-14, menthone glycerol acetal, (3-(L-menthyloxy)-2-methyl-1,2-propanediol, 3-(1-methoxy)-2-methyl-1,2-propanediol, cis- and trans-p-menthane-3,8-diol, 2,3-dihydroxymenthane, 3,3,5-trimethylcyclohexanone glycerol ketal, 3,6-dioxaoctanoic acid (1R,3R,4S)-3-menthyl ester, methoxyacetic acid (1R,2S,5R) menthyl ester, 3,6,9-trioxadecenoic acid-(1R,2S,5R)-3-menthyl ester, (2-hydroxyethoxy)acetic acid-(1R,2S,5R)-3-menthyl ester, and 11-hydroxy-3,6,9-trioxaundecanoic acid-(1R,2S,5R)-menthyl ester.

15. The nicotine composition sachet according to claim 1 or 2, characterized in that, The nicotine composition may further include a preservative. The preservative includes one or a combination of sorbic acid and its salts, dehydroacetic acid and its sodium salts, parabens, sodium diacetate, calcium propionate, and sodium / calcium lactate.

16. A method for preparing a nicotine composition sachet, characterized in that, It includes the following specific steps: S1. Granulate according to the formulation amount of the nicotine composition described in any one of claims 1 to 14 to obtain a nicotine composition with a particle size ≤ 500 microns, a humidity of 10% - 30%, and a Carr index of the tapped density ≤ 20%; S2. Load the nicotine composition into the non-woven fabric sachet; S3. According to the formulation amount of the coating solution described in any one of claims 1 to 15, mix the purified water, flavoring agent, sweetening agent, humectant, cooling agent, and nicotine to prepare a coating solution; S4. Add the non-woven fabric sachet containing nicotine composition particles into a coating machine. After the coating solution is sprayed, a nicotine composition sachet with a humidity of 30 - 50% is obtained.

17. The method for preparing a nicotine composition sachet according to claim 16, characterized in that, In S1, it specifically includes: First, take the solid powders of nicotine, sugar alcohol, pH regulator, and filler and add them to a double-cone mixer for premixing for 5 - 10 minutes at a rotation speed of 6 revolutions per minute. After mixing, load them into a barrel; Add the obtained material to a wet granulator for granulation. Start the stirring paddle at a speed of 100 - 200 revolutions and stir for 3 - 5 minutes, then start the spraying mode; At the same time, weigh the purified water, binder, humectant, flavoring agent, and dispersant and add them to a slurry preparation tank for preparation. Among them, the stirring speed is 100 - 1500 revolutions per minute, and the stirring time is 10 - 30 minutes. Add the material to the wet granulator through a pump and complete the filling within 3 - 8 minutes. At the same time, start the granulation mode and stir for 5 - 10 minutes, then stop the machine and take out the material; Put the obtained material into a particle packaging machine for particle packaging, and set the speed of the particle machine to 120 particles per minute to obtain the nicotine composition.

18. The method for preparing a nicotine composition sachet according to claim 16, wherein In S4, it specifically includes: Add the non-woven fabric sachet containing nicotine composition particles into a coating machine, set the rotation speed of the coating machine to 5 - 10 revolutions per minute, and the spraying flow rate to 5 - 60 revolutions per minute. After the coating solution is sprayed, the coating machine continues to rotate for 5 - 30 minutes to obtain the nicotine composition sachet.

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