Compositions and methods for delivering nucleic acids to podocytes

A podocyte-tropic AAV capsid delivers therapeutic polypeptides to renal glomerular podocytes, addressing the lack of effective targeting methods and treating steroid-resistant nephrotic syndrome by reducing proteinuria.

WO2025194082A1PCT designated stage Publication Date: 2025-09-18CHILDRENS MEDICAL CENT CORP +1
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Patent Information

Application Number
PCT/US2025/020011
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-03-15
Filing Date
2025-03-14
Publication Date
2025-09-18

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Abstract

Provided herein are materials and methods for efficient and / or tropic delivery of transgenes to podocytes, and methods of treating podocytopathies associated with a genetic defect.
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Citation Information

Patent Citations

  • NPHS2 gene involved in the steroid-resistant nephrotic syndrome, protein encoded by said gene and diagnostic and therapeutic uses

    US20050266484A1

  • Redirection of tropism of AAV capsids

    US20220042044A1

  • Agents and methods for treating complement diseases

    WO2024146953A1