Optical cochlear implant assemblies, optrode leads, and methods of implementing the same

Optical cochlear implant assemblies with optrode leads and controlled compound release address inefficiencies in conventional systems by stabilizing and maintaining neural sensitivity, improving surgical handling and longevity.

WO2025198592A1 Publication Date: 2025-09-25ADVANCED BIONICS LLC
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Patent Information

Application Number
PCT/US2024/020867
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-03-21
Publication Date
2025-09-25

AI Technical Summary

Technical Problem

Conventional cochlear implant systems face challenges in achieving efficient and long-term expression of light-sensitive opsins in target cells due to immunogenic responses, opsin overexpression toxicity, and reduced expression over time, necessitating invasive procedures and risking inflammation or infection.

Method used

The development of optical cochlear implant assemblies with optrode leads that include an elastomeric encapsulant impregnated with compounds to facilitate light sensitivity, featuring self-curling materials for stabilization and controlled release of neurotrophic factors and immunosuppressants, minimizing immunogenic responses and promoting neural survival.

Benefits of technology

The solution enhances surgical handling, improves optical stimulation efficiency, and extends the operational life of cochlear implants by stabilizing optrode leads and maintaining neural sensitivity over time.

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Abstract

An exemplary optical cochlear implant assembly adapted for insertion into a recipient may comprise an optrode lead configured to be inserted at least partially within a cochlea of the recipient. The optrode lead may include a plurality of optrodes and an elastomeric encapsulant that encapsulates the plurality of optrodes and that includes one or more portions impregnated with a compound that facilitates light sensitivity of neurons of the cochlea. The optical cochlear implant assembly may further include an implantable cochlear stimulator (ICS) configured to deliver optical stimulation to the recipient by way of one or more optrodes included in the plurality of optrodes.
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