Processing method for traditional chinese medicine prescription, system, device and computer-readable storage medium

Abstract

Disclosed in the present invention are a processing method for a traditional Chinese medicine prescription, a system, a device and a computer-readable storage medium. The method comprises: acquiring a traditional Chinese medicine prescription to be processed; acquiring one or more basic formulations similar to said traditional Chinese medicine prescription, and performing analysis to select a suitable basic formulation; performing prescription decomposition on said traditional Chinese medicine prescription, so as to decompose same into the basic formulation and additive components; calculating the required amount of the basic formulation and the amount of one or more traditional Chinese medicine extracts or processed products to be added; and mixing the basic formulation with said traditional Chinese medicine extracts or processed products to obtain a traditional Chinese medicine formulation conforming to said traditional Chinese medicine prescription. The processing method, the system, the device and the computer-readable storage medium of the present invention realize the simple and quick processing of traditional Chinese medicine prescriptions so as to facilitate convenient and efficient use of traditional Chinese medicines, and also enable medicinal materials to be decocted together during preparing processes of the traditional Chinese medicines, so as to result in chemical reactions and mutual interactions, thereby ensuring the effect of prepared traditional Chinese medicines.

Description

A method, system, equipment, and computer-readable storage medium for processing traditional Chinese medicine prescriptions. Technical Field

[0001] This invention relates to the technical field of intelligent medical information processing, and in particular to a method, system, equipment, and computer-readable storage medium for processing traditional Chinese medicine prescriptions. Background Technology

[0002] With the continuous development of traditional medicine, traditional medicine has received increasing attention, especially globally, where the demand for traditional Chinese medicine (TCM) is growing. This has created a vast space for the development of TCM, which has entered a stage of rapid growth. Traditional decoctions, as the earliest and most widely used form of TCM application, have become a major vehicle for showcasing the advantages and characteristics of TCM prescriptions due to their flexibility in adjusting the composition according to the patient's condition. However, in the context of the fast-paced lifestyle of modern society and the modernization of TCM, the use of traditional decoctions faces challenges such as the need for decoction and inconvenient storage, which seriously limit their wider application and development.

[0003] Against this backdrop, traditional Chinese medicine (TCM) formula granules emerged and quickly gained popularity due to their ease of use. TCM formula granules are a new type of granular TCM made from single-herb traditional Chinese medicinal slices through a series of modern pharmaceutical processes including extraction, separation, concentration, drying, granulation, and packaging. These granules require no decoction; they are simply mixed according to the prescription and dissolved in boiling water before consumption, offering advantages such as convenience, small size, and portability. However, because TCM formula granules do not involve decocting multiple herbs together as per the prescription, the chemical reactions and interactions that might occur during traditional decoction are not fully reproduced. The decoction methods, order, and time of each herb in a traditional Chinese medicine decoction are themselves crucial components of the prescription, ensuring the decoction conforms to traditional TCM theory and exerts its therapeutic effect. Therefore, questions persist regarding the efficacy equivalence of TCM formula granules compared to traditional decoctions.

[0004] Therefore, there is an urgent need to develop a new method for processing traditional Chinese medicine (TCM) prescriptions, along with its supporting systems, equipment, and computer-readable storage media. This method aims to simplify and expedite the processing of TCM prescriptions, ensuring that multiple herbs are decocted together according to the prescription's instructions, maximizing the chemical reactions and interactions between the herbs. This guarantees that the processed TCM is not only convenient and quick to use but also has good efficacy and is safe and reliable. The goal is to ensure that the TCM used by patients is processed according to traditional Chinese medicine decoction methods, that the efficacy of the TCM prescription conforms to traditional TCM theory, and that the TCM prescription is convenient and quick to use.

[0005] Summary of the Invention

[0006] The main objective of this invention is to address the problem that while existing Chinese herbal medicine (TCM) granules improve the convenience and speed of TCM decoctions, they cannot ensure the efficacy and safety of TCM decoctions by allowing the medicinal materials to fully react through specific decoction methods according to TCM theory. This invention provides a TCM formula processing method, system, equipment, and computer-readable storage medium. By establishing a basic formulation library, the basic formulation is mixed with the required TCM extracts or processed materials to obtain TCM formulations that conform to the TCM prescription. This achieves both batch processing and convenient and fast use of TCM formulas, and ensures that all medicinal materials are fully decocted together during the TCM preparation process to produce relevant reactions, guaranteeing the TCM's good efficacy and safety.

[0007] To achieve the above objectives, the present invention provides a method for processing traditional Chinese medicine prescriptions, the method comprising:

[0008] Step 1: Obtain the prescription for the Chinese herbal medicines that need to be processed;

[0009] Step 2: Obtain one or more basic preparations similar to the Chinese medicine prescription, analyze the medicinal materials contained in the Chinese medicine prescription and the basic preparations, as well as the dosage, decoction method, decoction order and decoction time of each herb, and select a suitable basic preparation;

[0010] Step 3: Based on the selected basic preparation, the traditional Chinese medicine prescription is broken down into a basic preparation and added ingredients, wherein the added ingredients are one or more traditional Chinese medicine extracts or processed products that need to be added.

[0011] Step 4: Calculate the required amount of the basic preparation and the amount of one or more Chinese herbal extracts or processed products to be added;

[0012] Step 5: Mix the pre-processed basic preparation with the required Chinese herbal extracts or processed products to obtain a Chinese herbal preparation that conforms to the Chinese herbal prescription.

[0013] In the processing method of a traditional Chinese medicine prescription as described above, step 2 further includes:

[0014] By comparing the Chinese herbal medicine prescriptions with various basic preparations, the effects of differences in the medicinal materials contained in the Chinese herbal medicine prescriptions and various basic preparations, as well as the dosage, decoction method, decoction order, and decoction time of each herb, on the medicinal properties were analyzed. Basic preparations with minimal impact on medicinal properties from the Chinese herbal medicine prescriptions were selected as suitable basic preparations.

[0015] The method for selecting a suitable basic preparation in the processing method of a traditional Chinese medicine formula as described above is as follows:

[0016] The traditional Chinese medicine prescription X and the basic preparation to be selected contain a total of n herbs X1, X2, ..., Xn.

[0017] W(Xi) represents the effect of the weight difference of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where Wt is the threshold for the effect of weight difference on medicinal properties. M(Xi) represents the effect of the difference in decoction method of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where Mt is the threshold for the effect of the effect of the difference in decoction method on medicinal properties. S(Xi) represents the effect of the difference in decoction order of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where St is the threshold for the effect of ...

[0018] P(X) indicates whether the basic preparation can be used as a suitable basic preparation for traditional Chinese medicine prescription X.

[0019] The method for processing a traditional Chinese medicine prescription as described above further includes: comparing the traditional Chinese medicine prescription with the selected basic preparation; supplementing the basic preparation with the corresponding missing or insufficient traditional Chinese medicine extracts or processed products by adding the missing or insufficient traditional Chinese medicine extracts or processed products; or neutralizing the basic preparation with the corresponding excess or excessive traditional Chinese medicine extracts or processed products by adding the corresponding traditional Chinese medicine extracts or processed products to counteract the excess medicinal properties.

[0020] The method for processing a traditional Chinese medicine formula as described above, further includes the method for selecting a suitable basic preparation:

[0021] A basic formulation selection database was established, comprising the mechanism and corresponding value of each herb in different traditional Chinese medicine prescriptions during the decoction process, as well as the magnitude and corresponding value of its effect during the decoction process. This database was established through methods including traditional Chinese medicine theory, clinical trials, big data analysis, and expert-based manual setting based on experience.

[0022] When selecting a basic formulation, the differences between the basic formulation and the traditional Chinese medicine prescription are used to determine the amount of traditional Chinese medicine extracts or processed substances that need to be added after selecting the basic formulation, and the amount of traditional Chinese medicine extracts or processed substances that need to be added is analyzed.

[0023] Based on the basic formulation selection database, the mechanism and magnitude of action of the Chinese herbal medicines (TCMs) to be added to the basic formulation during the decoction process of the TCM prescription are read. Combined with the required amount, the difference between the mixed formulation obtained by selecting the basic formulation and adding the corresponding TCM extracts or processed products and the original processing (decoction method) of the TCM prescription can be determined. The greater the difference, the higher the score of the basic formulation.

[0024] The above analysis was performed on each of the candidate basic preparations, and the basic preparation with the lower comprehensive score for the original Chinese medicine prescription was selected as the suitable basic preparation.

[0025] The specific calculation method is as follows:

[0026] The selected basic formulation needs to contain Chinese herbal extracts or processed products Y1, Y2, ..., Yn.

[0027] D(Yi) represents the amount of Yi that needs to be added, f(Yi) represents the value corresponding to the mechanism of action of Yi in the original prescription, R(Yi) represents the value corresponding to the function of Yi in the original prescription, and Q represents the comprehensive score of the basic preparation to be selected.

[0028] The above-described method for processing traditional Chinese medicine (TCM) formulas involves selecting more than one basic preparation, calculating the required amount of each basic preparation based on the TCM prescription and the selected basic preparations, and then mixing the more than one basic preparation to obtain a TCM formula conforming to the TCM prescription. If the TCM prescription requires more than one basic preparation and also needs to add other ingredients, the method calculates the amount of one or more TCM extracts or processed products to be added, and then mixes the required TCM extracts or processed products with the more than one basic preparation to obtain a TCM formula conforming to the TCM prescription.

[0029] The above-described method for processing traditional Chinese medicine formulas further includes: establishing a basic preparation library, wherein the basic preparations are based on existing prescription data or classic prescriptions, obtained through data analysis, suitable for mass production and processing, and can be supplemented with traditional Chinese medicine extracts or processed products as needed to form basic preparations that can be widely applied to similar traditional Chinese medicine prescriptions.

[0030] This invention also provides a traditional Chinese medicine prescription processing system, the system comprising: a data acquisition module, a basic preparation selection module, a prescription splitting module, a dosage calculation module, and a mixing and processing module.

[0031] The data acquisition module is used to acquire the Chinese medicine prescription that needs to be processed and to acquire one or more basic preparations similar to the Chinese medicine prescription;

[0032] The basic preparation selection module is used to analyze the medicinal materials contained in the Chinese medicine prescription and basic preparation, as well as the dosage, decoction method, decoction order and decoction time of each herb, and select a suitable basic preparation.

[0033] The prescription splitting module is used to split the traditional Chinese medicine prescription according to the selected basic preparation, breaking it down into a basic preparation and added ingredients, wherein the added ingredients are one or more traditional Chinese medicine extracts or processed products that need to be added.

[0034] The dosage calculation module is used to calculate the required amount of basic preparation and the amount of one or more Chinese herbal extracts or processed products to be added, based on the Chinese herbal prescription and the selected basic preparation.

[0035] The mixing and processing module is used to mix the pre-processed basic preparation with the required Chinese herbal extracts or processed materials to obtain a Chinese herbal preparation that conforms to the Chinese herbal prescription.

[0036] The present invention also provides a computer device, including a memory and a processor, wherein the memory stores a computer program, and the processor executes the computer program to implement the steps of the traditional Chinese medicine formula processing method as described above.

[0037] The present invention also provides a computer-readable storage medium storing a computer program that, when executed by a processor, implements the steps of the traditional Chinese medicine formula processing method described above.

[0038] This invention discloses a method, system, device, and computer-readable storage medium for processing traditional Chinese medicine (TCM) prescriptions. The method includes: acquiring a TCM prescription to be processed; acquiring one or more basic preparations similar to the TCM prescription, and analyzing and selecting suitable basic preparations; splitting the TCM prescription into basic preparations and added ingredients; calculating the required amount of basic preparations and the amount of one or more TCM extracts or processed substances to be added; and mixing the basic preparations and the required TCM extracts or processed substances to obtain a TCM preparation conforming to the TCM prescription. The system includes: a data acquisition module, a basic preparation selection module, a prescription splitting module, a dosage calculation module, and a mixing and processing module. This invention, by establishing a basic preparation library and mixing basic preparations with required TCM extracts or processed substances to obtain a TCM preparation conforming to the TCM prescription, achieves both simple and rapid processing of TCM prescriptions, making TCM use convenient and quick, and also ensures that the chemical reactions and interactions between the various medicinal materials produced during the decoction process guarantee the efficacy and safety of the processed TCM. Attached Figure Description

[0039] Figure 1 is a flowchart of the processing method of the traditional Chinese medicine prescription of the present invention.

[0040] Figure 2 is a schematic diagram of the traditional Chinese medicine formula processing system of the present invention. Detailed Implementation

[0041] To further illustrate the technical means and effects adopted to achieve the intended purpose of this application, the specific implementation methods of this application will be described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the embodiments described herein are merely for explaining this application and are not intended to limit this application.

[0042] The first embodiment of the present invention is illustrated in Figure 1. Figure 1 is a flowchart of the processing method of the traditional Chinese medicine formula of the present invention. As shown in the figure, the processing method of the traditional Chinese medicine formula of the present invention includes:

[0043] Step 1: Obtain the prescription for the Chinese herbal medicine that needs to be processed.

[0044] The aforementioned traditional Chinese medicine prescription is a targeted prescription given by a doctor after diagnosing a patient, based on the patient's symptoms and actual physical condition. This prescription may be the same as a classic prescription for treating the same disease or a commonly used basic prescription in a hospital / department / doctor, or it may be similar to a classic prescription or commonly used basic prescription, but the doctor may make minor adjustments based on the patient's condition or due to environmental or climatic factors to arrive at the actual traditional Chinese medicine prescription.

[0045] A typical Chinese medicine prescription includes the ingredients, their processed forms and dosages, the decoction method (including the order and time), usage, footnotes, and any special decoction ingredients. For example: Qingfei Paidu Decoction: Ephedra 9g, Prepared Licorice Root 6g, Apricot Kernel 9g, Gypsum 15-30g (decocted first), Cinnamon Twig 9g, Alisma Rhizome 9g, Polyporus Rhizome 9g, Atractylodes Rhizome 9g, Poria 15g, Bupleurum Root 16g, Scutellaria Root 6g, Ginger-processed Pinellia Rhizome 9g, Fresh Ginger 9g, Aster Root 9g, Coltsfoot Flower 9g, Belamcanda Rhizome 9g, Asarum 6g, Dioscorea Rhizome 12g, Immature Bitter Orange 6g, Tangerine Peel 6g, Patchouli 9g. Decoct in water and take one dose daily, twice a day (40 minutes after meals), warm. Three doses constitute one course of treatment. For example, Zhenwu Decoction: 15g Poria cocos, 10g Paeonia lactiflora, 10g Atractylodes macrocephala, 10g fresh ginger, 5g prepared Aconitum carmichaelii. Decocted in water, taken 3 times a day, one dose per day.

[0046] In this invention, traditional Chinese medicine prescriptions can be obtained from user prescriptions, doctor's orders, medical records, electronic medical records, various medical databases, or other suitable means.

[0047] Step 2: Obtain one or more basic preparations similar to the Chinese medicine prescription, analyze the dosage, decoction method, decoction order and decoction time of each herb in the Chinese medicine prescription and basic preparations, and select a suitable basic preparation.

[0048] In this invention, a basic preparation library can be established. One or more basic preparations are created based on clinically used traditional Chinese medicine (TCM) prescription information. These basic preparations are stored in a database to form a basic preparation database, which is used in the TCM prescription processing method of this invention. When establishing the basic preparation library, whether a prescription can serve as a basic preparation is considered by comprehensively evaluating factors such as the TCM prescription combinations (including decoction methods) within different TCM prescription supply ranges (region, hospital, department, pharmacy / chain, decoction center, disease type, community), the quantity demand processing capacity of various combinations, and the number of doses supplied per unit time. Specifically, the library can be established by acquiring a large amount of prescription data based on different regions, hospitals, departments, pharmacies / chains, decoction centers, and diseases. The prescription data is analyzed, similar prescriptions are grouped, and the common parts of the same group of prescriptions are used as a basic prescription based on the herbs, dosage of each herb, decoction method, decoction time, and decoction order. If the basic prescription is confirmed to be suitable for mass production, it can be included in the basic preparation library.

[0049] The basic preparation can be a basic preparation based on existing prescription data (including commonly used basic prescriptions from different hospitals, departments, and doctors, as well as commonly used basic prescriptions for specific patients and diseases) or classic prescriptions. It can be obtained through data analysis and is suitable for mass production and processing. It can also be formulated with the addition of Chinese herbal extracts or processed substances as needed to form a basic preparation that can be widely applied to similar Chinese herbal prescriptions. The dosage forms of the basic preparation and the Chinese herbal extracts or processed substances can include: decoction / concentrated decoction, granules, powders, ointments, oils, syrups, etc. The processing involves first decocting the prescription (the basic prescription selected as the basic preparation) according to the traditional Chinese medicine processing methods, including the weight ratio of the medicinal materials, the corresponding amount of water, the order of addition, the decoction method, and the decoction time. After obtaining the stock solution, further processing is carried out according to the corresponding process as needed to obtain the basic preparation in various dosage forms. The processing method of the added Chinese herbal extracts / processed substances is similar to that of the basic preparation.

[0050] For example, regarding Zhenwu Decoction, analysis of numerous existing prescriptions revealed three common formulations: The first is: Poria 15g, Paeonia lactiflora 10g, Atractylodes macrocephala 10g, fresh ginger 10g, and processed aconite 5g; the second is: Poria 10g, Paeonia lactiflora 10g, Atractylodes macrocephala 10g, fresh ginger 10g, and processed aconite 5g; the third is: Poria 10g, Paeonia lactiflora 15g, Atractylodes macrocephala 10g, fresh ginger 10g, and processed aconite 5g. To facilitate application to a wider range of similar Chinese herbal prescriptions, the basic formulation of Zhenwu Decoction could be: Poria 10g, Paeonia lactiflora 10g, Atractylodes macrocephala 10g, fresh ginger 10g, and processed aconite 5g. Thus, when the actual prescription is the first one, an extract or processed form equivalent to 5g of Poria 10g can be added to the basic formulation to create a Chinese herbal preparation conforming to the first prescription. When the actual traditional Chinese medicine (TCM) prescription is the second type, since the TCM prescription is the same as the basic preparation, the basic preparation can be directly used as the TCM preparation for the second prescription. When the actual TCM prescription is the third type, a TCM preparation conforming to the third prescription can be formed by adding an extract or processed product equivalent to 5 grams of peony root to the basic preparation. In this way, all three prescriptions can conveniently use the basic preparation and obtain TCM preparations using the TCM formula processing method of this invention. However, if 15 grams of Poria cocos, 10 grams of peony root, 10 grams of Atractylodes macrocephala, 10 grams of fresh ginger, and 5 grams of processed Aconitum carmichaelii are selected as the basic preparation, then when forming a TCM preparation conforming to the second prescription, it is necessary to add a TCM extract or processed product equivalent to 5 grams of Poria cocos to offset the excess medicinal properties; when forming a TCM preparation conforming to the third prescription, it is necessary to add a TCM extract or processed product equivalent to 5 grams of Poria cocos to offset the excess medicinal properties and 5 grams of peony root extract or processed product. It can be seen that this selection of the basic preparation leads to more complex additives when processing the TCM preparation. Furthermore, adding Chinese herbal extracts or processed products to counteract excess medicinal properties requires finding suitable drugs to counteract these properties, and it is also necessary to consider whether the drug has adverse interactions with other drugs in the prescription. Therefore, the difficulty and complexity are greater than adding existing Chinese herbal extracts or processed products.

[0051] After obtaining one or more basic preparations similar to the Chinese medicine prescription, analyze the medicinal materials contained in the Chinese medicine prescription and the basic preparation, as well as the dosage, decoction method, decoction order, and decoction time of each herb, and select a suitable basic preparation.

[0052] Factors to consider when analyzing suitable basic preparations include: selecting basic preparations based on the mechanisms by which different medicinal materials exert their effects in the entire Chinese medicine prescription, as well as the importance of their effects. Once the basic preparation is selected, the corresponding ingredients to be added are also determined. It is necessary to ensure that the effects of the Chinese medicine preparation made after mixing are as consistent as possible with those of the original Chinese medicine prescription, and to minimize any impact on the efficacy of the prescription.

[0053] The role of different medicinal materials in a prescription can be either to exert their medicinal properties independently or to work synergistically with other medicinal materials, such as enhancing, synthesizing, altering, being altered, being enhanced, inhibiting, or being inhibited. The different mechanisms of action determine the impact of adding a medicinal material as an additive to the base formulation on the overall prescription's effect, and also determine the impact of the amount added on the prescription's effect.

[0054] For example, a traditional Chinese medicine prescription: Si Ni San. Ingredients: Bupleurum, White Peony Root, Immature Bitter Orange, Licorice Root. Functions: Soothes the liver and relieves depression, harmonizes the liver and spleen.

[0055] Chemical reactions during the simmering process:

[0056] White peony root and licorice: Paeoniflorin in white peony root and glycyrrhizin in licorice may undergo esterification during decoction to generate new compounds. These compounds have stronger analgesic and anti-inflammatory effects.

[0057] Scientific basis: Paeoniflorin and glycyrrhizin can form a complex during decoction, which has stronger biological activity and can better relieve muscle spasms and inflammation. Studies have shown that the combination of paeoniflorin and glycyrrhizin can significantly improve the anti-inflammatory effect (Wang et al., 2018).

[0058] Bupleurum and Fructus Aurantii Immaturus: The volatile oils in Bupleurum and Fructus Aurantii Immaturus may have a synergistic effect during decoction, enhancing the liver-soothing and mood-lifting effects. Simultaneously, Fructus Aurantii Immaturus can promote better extraction of the effective components from Bupleurum.

[0059] Scientific basis: Both Bupleurum and Citrus aurantium contain volatile oils, which can synergistically enhance their medicinal effects during decoction. Studies have shown that the combination of Bupleurum and Citrus aurantium can significantly increase the activity of liver enzymes and improve liver function (Li et al., 2017).

[0060] For example, a traditional Chinese medicine prescription: Liu Jun Zi Tang (Six Gentlemen Decoction). Ingredients: Ginseng, Atractylodes macrocephala, Poria cocos, Licorice root, Tangerine peel, Pinellia ternata. Functions: Strengthens the spleen and replenishes qi, dries dampness and resolves phlegm.

[0061] Chemical reactions during the simmering process:

[0062] Atractylodes macrocephala and Poria cocos: The volatile oil in Atractylodes macrocephala and the polysaccharide components in Poria cocos may have a synergistic effect during decoction, enhancing the spleen-strengthening and dampness-removing effects.

[0063] Scientific basis: The volatile oil in Atractylodes macrocephala can promote gastrointestinal motility, while the polysaccharides in Poria cocos have a diuretic effect. The combination of the two can better improve the symptoms of spleen deficiency and dampness (Zhang et al., 2019).

[0064] Dried tangerine peel and pinellia: The volatile oil in dried tangerine peel and the alkaloids in pinellia may have a synergistic effect during decoction, enhancing the effect of drying dampness and resolving phlegm.

[0065] Scientific basis: The volatile oil in dried tangerine peel can promote gastric juice secretion, while the alkaloids in pinellia can relieve nausea and vomiting. The combination of the two can better improve symptoms of phlegm and dampness (Chen et al., 2016).

[0066] Licorice and Ginseng: Glycyrrhizin in licorice can increase the solubility of ginsenosides, allowing them to be better extracted and enhancing their effects of replenishing qi and promoting body fluid production.

[0067] Scientific basis: Glycyrrhizin can increase the solubility of ginsenosides, thereby increasing their precipitation during decoction. Studies have shown that the combination of licorice and ginseng can significantly improve the qi-tonifying effect (Wu et al., 2015).

[0068] For example, a traditional Chinese medicine prescription: Dang Gui Si Ni Tang. Ingredients: Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Asarum sieboldii, Tetrapanax papyriferus, Glycyrrhiza uralensis, Ziziphus jujuba. Functions: Warms the meridians and dispels cold, nourishes blood and unblocks the meridians.

[0069] Chemical reactions during the simmering process:

[0070] Angelica sinensis and peony: The volatile oil in Angelica sinensis and paeoniflorin in peony may have a synergistic effect during decoction, enhancing the blood-nourishing and blood-activating effects.

[0071] Scientific basis: The volatile oil in angelica can promote blood circulation, while paeoniflorin can relieve muscle spasms. The combination of the two can better improve symptoms of blood stasis (Liu et al., 2018).

[0072] Cinnamon twig and Asarum: The volatile oils in cinnamon twig and asarum may have a synergistic effect during decoction, enhancing the effect of warming the meridians and dispelling cold.

[0073] Scientific basis: Both cinnamon twigs and asarum contain volatile oils, which can synergistically enhance the effects of warming the meridians and dispelling cold during decoction. Studies have shown that the combination of cinnamon twigs and asarum can significantly increase body temperature and improve cold symptoms (Sun et al., 2017).

[0074] Licorice and Tetrapanax papyriferus: Glycyrrhizin in licorice can increase the solubility of polysaccharides in Tetrapanax papyriferus, allowing them to be better extracted and enhancing their diuretic and dampness-removing effects.

[0075] Scientific basis: Glycyrrhizin can increase the solubility of polysaccharides in Tetrapanax papyriferus, thereby increasing their extraction during decoction. Studies have shown that the combination of licorice and Tetrapanax papyriferus can significantly improve the diuretic effect (Zhao et al., 2016).

[0076] During the decoction process, the various herbs in a traditional Chinese medicine prescription undergo chemical reactions. These reactions include promoting the extraction of active ingredients, increasing solubility, and reducing toxicity. With the rapid modernization of traditional Chinese medicine, a wealth of experimental data and clinical research provides more scientific evidence, demonstrating the scientific validity and rationality of herbal combinations. Through proper combination and decoction, traditional Chinese medicine prescriptions can better exert their therapeutic effects.

[0077] Furthermore, because medicinal materials exert their effects through different mechanisms during the decoction process, the same medicinal material may have more than one effect in a prescription. For example, it may exert its own direct medicinal effect, or it may exert its effect in synergy with other medicinal materials during processing. The amount required to exert the effect of other medicinal materials is related to the amount of related medicinal materials. If the amount of the medicinal material in the basic prescription already exceeds the amount required to assist other medicinal materials in exerting their effects, then the amount of the medicinal material added alone or after being processed with other medicinal materials can be considered unrelated to the efficacy of other medicinal materials. Therefore, it can be considered that when the amount of the medicinal material in the basic prescription already exceeds the amount required for synergistic effect, the efficacy of the medicinal material after being added as a processed product has little impact on the efficacy of other medicinal materials in the original prescription, and it is suitable as an added Chinese herbal extract or processed product.

[0078] In this invention, the mechanisms by which medicinal materials exert their effects in prescriptions can be derived from traditional Chinese medicine theory, laboratory experiments and analysis, evidence-based medicine, big data analysis, and other sources. Analytical models can be established to analyze basic formulations suitable for traditional Chinese medicine prescriptions.

[0079] Factors to consider when analyzing suitable basic formulations include: minimal impact on drug properties; and conformity as closely as possible to the original prescription. This includes the type, amount, and function of any Chinese herbal extracts or processed substances added after selecting the basic formulation, as well as their roles in the original prescription and their interactions with other drugs during decoction. Priority should be given to the basic formulation that requires only the addition of Chinese herbal extracts or processed substances with minimal impact on the original prescription's drug properties. Accessibility, such as time and cost, must also be considered. During decoction, the effective components of the medicinal materials may undergo chemical changes, such as dissolution, decomposition, or the synthesis of new substances. These changes may affect the final efficacy of the medicine. Based on the main components of each herb in the prescription, the potential / mainly existing synthetic reactions, catalytic effects, and other chemical reactions during decoction can be analyzed. These chemical reactions include those between individual herb components, as well as reactions between new components formed after chemical reactions and other components.

[0080] The analysis of suitable basic preparations is based on: the role and importance of each herb in the Chinese medicine prescription, the dosage, decoction method, decoction order, and decoction time of each herb, and may also include chemical reactions, synergistic effects, antagonistic effects, enzymatic reactions, physical changes, precipitation formation, pH value effects, etc. that affect the medicinal properties.

[0081] Chemical reactions that affect the medicinal properties: Some components in medicinal materials may undergo chemical reactions during decoction, forming new substances. For example, some medicinal materials containing tannins may react with protein substances to form precipitation; some volatile oils may decompose or polymerize at high temperatures.

[0082] Synergistic effects on medicinal properties: When multiple medicinal materials are decocted together, their active ingredients may mutually promote absorption or enhance efficacy. For example, some medicinal materials can help the active ingredients in other medicinal materials be better absorbed by the body.

[0083] Antagonistic effects on the properties of medicines: that is, some medicinal materials may inhibit the release of the active ingredients of other medicinal materials or weaken their efficacy.

[0084] Enzymatic reactions that affect the properties of medicines: Some medicinal materials contain enzymes that can catalyze certain chemical reactions during decoction, leading to changes in the active ingredients.

[0085] Physical changes that affect the medicinal properties: Physical changes also occur during the decoction process, such as the expansion and disintegration of medicinal materials. These changes can also affect the release of active ingredients.

[0086] Precipitation formation that affects the efficacy of the medicine: When two or more medicinal materials are decocted together, precipitates may form due to the interaction between ions, which may affect the bioavailability of the medicine.

[0087] The effect of pH on medicinal properties: The pH of the decoction liquid can also affect the stability of certain components. Too high or too low pH may lead to the degradation of active ingredients.

[0088] Special decoction methods for traditional Chinese medicine may include: decocting first, adding later, decocting in a wrap, and melting.

[0089] First decoction: Generally, add 400-500 ml of water and bring to a boil over high heat for 15-20 minutes. Then add other common herbs, increasing the water to the appropriate level, and continue decocting. Herbs typically decocted first include: gypsum, calcite, magnetite, hematite, white quartz, amethyst, raw dragon bone, clam shell, raw abalone shell, oyster shell, tortoise shell, turtle shell, dragon teeth, leopard bone, deer antler, buffalo horn, and other minerals, shells, bones, tortoise shells, dragon teeth, leopard bone, deer antler, buffalo horn, and other minerals, shells, bones, tortoise shells, and horns, as well as hard materials whose active ingredients are difficult to extract through decoction. Additionally, toxic herbs such as aconite, pokeweed, raw arisaema, and raw pinellia are also included; prolonged decoction can mitigate their toxicity.

[0090] Adding later: Generally, it's best to add the herbs 5-10 minutes before the end of the decoction. Herbs added later typically include aromatic herbs containing volatile components, such as peppermint, cardamom, nutmeg, agarwood, cinnamon, and costus root. Additionally, herbs that cannot be decocted for long periods, such as uncaria, rhubarb, senna leaves, and cynanchum paniculatum, are also suitable for adding later.

[0091] Wrapped decoction: This refers to placing the medicine in a gauze bag and decocting it together with other medicines. Medicines that are wrapped for decoction generally include Lepidium seed, Plantago seed, silkworm excrement, Inula flower, talc powder, Liu Yi San, Indigo naturalis, Lycoperdon, and raw Typha pollen, which contain mucilage, villi, and are easily buoyant.

[0092] Melting: This involves heating and dissolving gelatinous, paste-like, sugary, or inorganic salt-based drugs in the decoction (after removing the residue) obtained from other decoctions to form a liquid dosage form. Drugs that can be melted include: donkey-hide gelatin, tortoise shell gelatin, deer antler gelatin, loquat leaf paste, Glauber's salt, and sodium sulfate. (6) Mixing for oral administration: This involves mixing the liquid drug with the decoction of other drugs. Drugs that can be mixed for oral administration include: bamboo sap, ginger juice, and fresh lotus root juice.

[0093] Furthermore, the rational combination of medicinal materials to avoid adverse reactions is also very important. In this invention, we can refer to classic Chinese medicine books and modern research results, and combine them with clinical experience to analyze and select suitable basic preparations based on various factors.

[0094] The method for processing traditional Chinese medicine formulas in this invention, wherein the method for selecting a suitable basic preparation is as follows:

[0095] A traditional Chinese medicine prescription X contains n herbs X1, X2, ..., Xn.

[0096] W(Xi) represents the effect of the weight difference of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where Wt is the threshold for the effect of weight difference on medicinal properties. M(Xi) represents the effect of the difference in decoction method of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where Mt is the threshold for the effect of the effect of the difference in decoction method on medicinal properties. S(Xi) represents the effect of the difference in decoction order of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where St is the threshold for the effect of ...

[0097] P(X) indicates whether the basic preparation can be used as a suitable basic preparation for traditional Chinese medicine prescription X.

[0098] In the traditional Chinese medicine formula processing method of the present invention, when selecting the basic preparation, it is also possible to give priority to selecting the basic preparation that has the closest medicinal properties to the traditional Chinese medicine formula after processing according to the traditional Chinese medicine processing method.

[0099] According to traditional Chinese medicine theory, the processing of medicinal materials according to prescriptions (mainly decoction) serves the following purposes: 1. Extracting active ingredients: During decoction, water, as a solvent, dissolves the active ingredients in the medicinal materials. Different medicinal materials contain different types of active substances, such as alkaloids, flavonoids, and saponins. These components can be effectively extracted in hot water, thus ensuring the efficacy of the medicine. 2. Promoting component transformation: Some components in medicinal materials need to be heated to transform into pharmacologically active forms. For example, some compounds may require heating to change their structure, thereby producing a therapeutic effect. In addition, heating can also destroy some enzymes in medicinal materials, preventing them from decomposing the active ingredients. 3. Reducing toxicity or side effects: For some medicinal materials with toxicity or potential side effects, appropriate decoction can reduce their toxicity or adverse reactions. For example, prolonged decoction can degrade or inactivate certain toxins, improving medication safety. 4. Enhancing synergistic effects: Traditional Chinese medicine prescriptions are usually composed of multiple medicinal materials. The decoction process helps the active ingredients of different medicinal materials interact, enhancing the overall therapeutic effect. This synergistic effect not only enhances the efficacy of the drug but also reduces the dosage of individual herbs, thereby minimizing potential side effects. Therefore, the processing method (decoction) is crucial for achieving the desired therapeutic effect.

[0100] However, after splitting the traditional Chinese medicine prescription into a basic preparation and added ingredients according to the method of the present invention, although the selected basic preparation can be kept as consistent as possible with the traditional Chinese medicine prescription in terms of medicinal materials and processing methods, the drug composition is not completely consistent with the original traditional Chinese medicine prescription. This may result in the medicinal materials of the basic preparation having an effect that is not completely consistent with the original traditional Chinese medicine prescription after processing. Therefore, the basic preparation corresponding to the splitting scheme that has the least impact on the overall processing process and processing results of the traditional Chinese medicine prescription should be selected first, so as to ensure that the effect of the splitting scheme is as close as possible to the original traditional Chinese medicine prescription.

[0101] Analyzing suitable basic formulations requires minimizing the impact of the basic formulation and necessary additives on the efficacy of the original prescription. Factors to consider include: the type and amount of Chinese herbal extracts or processed substances to be added after selecting the basic formulation, their role in the original prescription, and the mechanism by which they exert their effects; the role of different medicinal materials in the entire Chinese herbal prescription, either individually or synergistically with other medicinal materials; and the analysis of chemical reactions occurring in the medicinal materials during decoction, including the generation of new components, promotion of the precipitation of effective components, alteration of solubility, and reduction of toxicity. These chemical reactions include both those between individual medicinal components and reactions between new components generated after chemical reactions and other components.

[0102] The method for processing traditional Chinese medicine formulas of the present invention, wherein the method for selecting a suitable basic preparation further includes:

[0103] A basic formulation selection database was established, comprising the mechanism and corresponding value of each herb in different traditional Chinese medicine prescriptions during the decoction process, as well as the magnitude and corresponding value of its effect during the decoction process. This database was established through methods including traditional Chinese medicine theory, clinical trials, big data analysis, and expert-based manual setting based on experience.

[0104] When selecting a basic formulation, the differences between the basic formulation and the traditional Chinese medicine prescription are used to determine the amount of traditional Chinese medicine extracts or processed substances that need to be added after selecting the basic formulation, and the amount of traditional Chinese medicine extracts or processed substances that need to be added is analyzed.

[0105] Based on the basic formulation selection database, the mechanism and magnitude of action of the Chinese herbal medicines (TCMs) to be added to the basic formulation during the decoction process of the TCM prescription are read. Combined with the required amount, the difference between the mixed formulation obtained by selecting the basic formulation and adding the corresponding TCM extracts or processed products and the original processing (decoction method) of the TCM prescription can be determined. The greater the difference, the higher the score of the basic formulation.

[0106] The above analysis was performed on each of the candidate basic preparations, and the basic preparation with the lower comprehensive score for the original Chinese medicine prescription was selected as the suitable basic preparation.

[0107] The specific calculation method is as follows:

[0108] The selected basic formulation needs to contain Chinese herbal extracts or processed products Y1, Y2, ..., Yn.

[0109] D(Yi) represents the amount of Yi that needs to be added, f(Yi) represents the value corresponding to the mechanism of action of Yi in the original prescription, R(Yi) represents the value corresponding to the function of Yi in the original prescription, and Q represents the comprehensive score of the basic preparation to be selected.

[0110] If the mechanism of action of Yi in the processing of the original prescription is to act alone, the score of f(Yi) is 0; if the mechanism of action of Yi in the original prescription is to react with other medicinal materials during the processing, the score of f(Yi) is relatively high, and the value can be assigned according to the type of chemical reaction that Yi participates in during the processing and the role it plays in the chemical reaction. The more the amount of Yi and the more important the role it plays in the reactions involved in the processing of the original prescription, the higher R(Yi); on the contrary, the less important the role it plays in the reactions involved in the processing of the original prescription, the lower the weight value R(Yi). The lower the comprehensive score Q of the to-be-selected basic preparation finally calculated, the more suitable the to-be-selected basic preparation is as a basic preparation; the higher the comprehensive score Q, the less suitable the to-be-selected basic preparation is as a basic preparation.

[0111] The processing method of the traditional Chinese medicine prescription of the present invention can also be to set relative weights respectively according to the functions and importance of each medicinal material in the traditional Chinese medicine prescription, as well as the dosage, decocting method, decocting order, decocting time, etc. of each medicinal material, so that when selecting a suitable basic preparation, the suitability of each basic preparation to the traditional Chinese medicine prescription can be calculated according to the differences between the basic preparation and the traditional Chinese medicine prescription and the relative weights of various factors, and it is used to select a suitable basic preparation.

[0112] The processing method of the traditional Chinese medicine prescription of the present invention can also be to analyze the functions and importance of each medicinal material in the traditional Chinese medicine prescription and the basic preparation, and obtain the monarch drug, ministerial drug, adjuvant drug, and courier drug in each prescription.

[0113] "Monarch, minister, adjuvant, and courier" refers to the different functions of each medicinal material in the traditional Chinese medicine prescription, that is, from the perspective of multiple drug use, it discusses the status of each drug in the prescription and the law of the change of nature and efficacy after compatibility. It highly summarizes the principle of traditional Chinese medicine prescription composition and has extremely important significance for the formation of traditional Chinese medicine prescriptions and guiding the rational use of drugs in clinical practice.

[0114] Monarch drug: That is, the drug that plays a major therapeutic role in the main syndrome or main disease of the prescription. It reflects the main attack direction of the prescription, and its medicinal power ranks first in the prescription and is an indispensable drug in the prescription composition.

[0115] Ministerial drug: It is a drug that assists the monarch drug to strengthen the treatment of the main disease and main symptoms.

[0116] Adjuvant drug: The first meaning is the assistant drug, which is used to treat secondary concurrent syndromes; the second meaning is the drug that restrains the toxicity or pungency of the monarch drug and ministerial drug; the third meaning is the drug that is used according to the needs of the disease condition and is contrary to the property of the monarch drug but can play a complementary role in the treatment.

[0117] Courier drug: The first meaning is the drug that guides all the drugs in the prescription to reach the affected area; the second meaning is the drug that harmonizes the functions of all the drugs, making them work together to dispel pathogenic factors. For example, achyranthes bidentata and licorice are often used as courier drugs in prescriptions.

[0118] Generally speaking, the roles and importance of Chinese medicine are ranked as follows: principal medicine > assistant medicine > adjuvant medicine > guiding medicine.

[0119] By analyzing the functions and importance of each herb in traditional Chinese medicine prescriptions and basic preparations, the principal, assistant, adjuvant, and guiding herbs in each prescription are identified. Then, by comparing the prescriptions with the basic preparations, and based on the number and importance of the same herbs in each prescription, as well as the preparation methods of the traditional Chinese medicine, the basic preparation with the highest suitability to the prescription is determined.

[0120] Based on the analysis of the principal, assistant, adjuvant, and guiding herbs in each prescription, the basic preparation whose principal herb matches the prescription should be prioritized as the suitable basic preparation. If multiple basic preparations have principal herbs that match the prescription, then the assistant herbs should be compared, and the basic preparation whose assistant herbs also match the prescription should be selected as the suitable basic preparation. If multiple basic preparations have both principal and assistant herbs that match the prescription, then the adjuvant and guiding herbs should be compared in turn.

[0121] The traditional Chinese medicine (TCM) formula processing method of this invention compares the TCM prescription with a selected basic preparation. For herbs missing in the basic preparation, corresponding TCM extracts or processed products are added to the TCM prepared from the basic preparation by decoction. For herbs in excess in the basic preparation, corresponding TCM extracts or processed products are added to neutralize the excess properties. "Missing" includes the absence of the herb in the basic preparation or the presence of the herb in a quantity less than that in the TCM prescription. "Excess" includes the presence of a herb not in the TCM prescription in the basic preparation or a quantity of a herb in the basic preparation exceeding that in the TCM prescription.

[0122] In addition to selecting a suitable basic preparation based on the Chinese medicine prescription, this invention can also select the Chinese medicine extracts or processed products to be added based on the processing method of the added Chinese medicine ingredients. The Chinese medicine extracts or processed products whose processing method is consistent with the decoction method and time of the Chinese medicine in the original Chinese medicine prescription should be selected as much as possible to ensure the consistency of efficacy.

[0123] Step 3: Based on the selected basic preparation, the traditional Chinese medicine prescription is broken down into a basic preparation and added ingredients, wherein the added ingredients are one or more traditional Chinese medicine extracts or processed products that need to be added.

[0124] After selecting a suitable basic preparation, the traditional Chinese medicine (TCM) prescription can be broken down into a basic preparation and an additive component. The basic preparation and the required additives (TCM extracts or processed products) are then mixed to obtain a TCM preparation conforming to the prescription. The TCM prescription processing method of this invention, through step 2 above, selects a suitable basic preparation. Based on the mechanism of action and importance of different medicinal materials in the entire TCM prescription, it ensures that medicinal materials that play a crucial role in the prescription and need to synergize with other medicinal materials during decoction are used as the basic preparation. The basic preparation is prepared using traditional decoction methods, maximizing efficacy. Furthermore, large-scale production of the basic preparation, combined with the addition components mixed with the basic preparation according to the TCM prescription breakdown, ensures rapid and efficient TCM preparation, avoiding the need for individual decoction for each prescription and achieving quick and convenient use of TCM prescriptions. Simultaneously, it maximizes the efficacy of the TCM.

[0125] Step 4: Based on the Chinese medicine prescription and the selected basic preparation, calculate the required amount of Chinese medicine to be decocted from the basic preparation and the amount of one or more Chinese medicine extracts or processed products to be added.

[0126] The quantities mentioned here are based on the amounts of each medicinal material added before processing. Although, according to this invention, qualified basic preparations can be processed in large quantities, expanding production scale, reducing production costs, and obtaining a large number of processed preparations at once, and the processed preparations can be of various dosage forms, such as decoctions, powders, granules, pills, and ointments, the addition of materials must be in accordance with the prescription of the basic preparation. Different medicinal materials are added in a certain ratio and order, and after being decocted according to the requirements of the basic preparation prescription, further processing such as concentration and dehydration is carried out to finally obtain various dosage forms convenient for users. Therefore, by converting the amount of materials added before processing to the output after processing, the corresponding relationship between the amount of various dosage forms of the processed basic preparation and the amount of materials added before processing can be obtained. This allows us to provide users with the amount of processed basic preparations of various dosage forms that correspond to the amount of materials required by the original prescription, ensuring the accuracy of the user's medication dosage. Similarly, the processing and selection of the added Chinese herbal ingredients and the calculation method for the dosage of the processed preparation are the same as for the basic preparation.

[0127] For example, a basic prescription based on Zhenwu Decoction consists of 15 grams of Poria cocos, 10 grams of Paeonia lactiflora, 10 grams of Atractylodes macrocephala, 10 grams of fresh ginger, and 5 grams of processed Aconitum carmichaelii. When processing this basic prescription in batches, the amount of raw materials added at one time is: 15 kilograms of Poria cocos, 10 kilograms of Paeonia lactiflora, 10 kilograms of Atractylodes macrocephala, 10 kilograms of fresh ginger, and 5 kilograms of processed Aconitum carmichaelii. After a series of processes such as decoction and dehydration, 1000 grams of basic preparation are obtained. The amount of each gram of basic preparation is equivalent to the amount of decoction obtained by traditional decoction of 15 grams of Poria cocos, 10 grams of Paeonia lactiflora, 10 grams of Atractylodes macrocephala, 10 grams of fresh ginger, and 5 grams of processed Aconitum carmichaelii.

[0128] In the traditional Chinese medicine formula processing method of the present invention, the amount of traditional Chinese medicine required to be prepared by decocting the basic preparation is calculated based on the ratio of the amount of the same medicine contained in the traditional Chinese medicine prescription and the basic preparation.

[0129] For example:

[0130] The Chinese medicine prescription is as follows: Poria cocos 15g, Paeonia lactiflora 10g, Atractylodes macrocephala 10g, fresh ginger 10g, and processed Aconitum carmichaelii 5g.

[0131] The basic preparation consists of: 10 grams of Poria cocos, 10 grams of Paeonia lactiflora, 10 grams of Atractylodes macrocephala, 10 grams of fresh ginger, and 5 grams of processed Aconitum carmichaelii.

[0132] The same herbs contained in the Chinese medicine prescription and the basic preparation include: Poria cocos, peony root, Atractylodes macrocephala, ginger, and prepared aconite root; the proportions of the herbs are: Poria cocos 150%, peony root 100%, Atractylodes macrocephala 100%, ginger 100%, and prepared aconite root 100%.

[0133] The required amount of Chinese medicine to be decocted from the basic preparation is calculated based on the ratio of the same herbs in the Chinese medicine prescription and the basic preparation. This ratio can be the lowest value, which in the example above is 100%, meaning one dose of the basic preparation is needed. Then, the amount of one or more Chinese herbal extracts to be added is calculated. In this case, Poria cocos is present in the prescription at 150% of the content in the basic preparation, requiring an additional 5 grams of Poria cocos. The advantage of selecting the lowest ratio as the required amount of Chinese medicine to be decocted from the basic preparation is that the amount of the same herbs in both the prescription and the basic preparation will not exceed the amount in the prescription, thus requiring less additional Chinese herbal extracts or processed substances to counteract excess medicinal properties during processing.

[0134] The traditional Chinese medicine formula processing method of the present invention can also select the average value of the proportion of drug dosages as the required amount of traditional Chinese medicine to be prepared by decocting the basic preparation. The advantage is that the amount of traditional Chinese medicine extracts or processed products that need to be added to a certain herb or to counteract the excess medicinal properties of a certain herb will not be too large.

[0135] In this invention, the herbal extract or processed product can be a single-herb extract or processed product, a mixed extract or processed product of multiple herbal products, or other suitable herbal extracts or processed products. The herbal extract or processed product can be herbal formula granules. Herbal formula granules are a novel type of granular herbal formula made from single-herb traditional medicinal slices through modern pharmaceutical processes such as extraction, separation, concentration, drying, granulation, and packaging. Most granular dosage forms of herbal medicine are in the molecular state of the effective components, rather than simply pulverizing traditional medicinal slices; therefore, they do not require decoction. The herbal extract or processed product can also be: medicinal juice / concentrated medicinal juice, granules, medicinal powder, medicinal paste, medicinal oil, medicinal syrup, etc.

[0136] Step 5: Mix the base preparation with the required Chinese herbal extracts or processed products to obtain a Chinese herbal preparation that conforms to the Chinese herbal prescription.

[0137] The traditional Chinese medicine (TCM) formula processing method of this invention establishes a basic formulation library and mixes the basic formulation with the required TCM extracts or processed materials to obtain a TCM formulation that conforms to the TCM prescription. This method achieves convenience and speed by mixing TCM prepared according to the existing basic formulation decoction with TCM additives, eliminating the need for fresh decoction according to the prescription. Furthermore, since the main components of the TCM formulation are existing TCM prepared according to the basic formulation decoction, the traditional method of decocting each herb together generates sufficient chemical reactions and interactions, ensuring the efficacy of the processed TCM and giving it good effectiveness and safety. For example, the efficacy of Shengmai San (ginseng, Ophiopogon japonicus, and Schisandra chinensis) decocted together is significantly stronger than that of a powder made by mixing the extracts of the above three herbs; the efficacy of Si Ni Tang (acupuncture root, dried ginger, and prepared licorice root) decocted together is not only significantly stronger than that of a powder made by mixing them, but also the toxicity of aconitine contained in aconite is greatly reduced, resulting in high safety.

[0138] In this invention, traditional Chinese medicine prepared by decocting a basic preparation is mixed with the required traditional Chinese medicine extracts or processed products to obtain a traditional Chinese medicine preparation conforming to the prescription. This preparation can be a decoction, granules, capsules, pills, etc. The mixing method is not limited to mixing the same preparation; different preparations can also be mixed, or the preparation can be dissolved / decocted first and then mixed.

[0139] The traditional Chinese medicine (TCM) preparation processing method of the present invention can further involve selecting more than one basic preparation in step 2, calculating the required amount of each basic preparation based on the TCM prescription and the selected basic preparations, and then mixing the more than one basic preparation to obtain a TCM preparation conforming to the TCM prescription. If the TCM prescription requires more than one basic preparation and also needs to add ingredients, the method calculates the amount of one or more TCM extracts or processed substances to be added, and then mixes the required TCM extracts or processed substances with the more than one basic preparation to obtain a TCM preparation conforming to the TCM prescription. Appropriately selecting multiple basic preparations for the final preparation of the TCM may make the TCM processing process more convenient. For example, if a single basic preparation is selected, it may be necessary to add TCM extracts or processed substances of multiple herbs. If another basic preparation can cover these herbs, multiple basic preparations can be selected, and the appropriate amount of TCM prepared by decocting each basic preparation, along with the TCM extracts or processed substances that may or may not be added and their required amounts, can be mixed to obtain a TCM preparation conforming to the TCM prescription.

[0140] The second embodiment of the present invention is shown in Figure 2. Figure 2 is a schematic diagram of the traditional Chinese medicine formula processing system of the present invention. As shown in the figure, the traditional Chinese medicine formula processing system of the present invention includes: a data acquisition module 101, a basic preparation selection module 102, a prescription splitting module 103, a dosage calculation module 104, and a mixing processing module 105.

[0141] The data acquisition module 101 is used to acquire the Chinese medicine prescription that needs to be processed and to acquire one or more basic preparations similar to the Chinese medicine prescription;

[0142] The basic preparation selection module 102 is used to analyze the dosage, decoction method, decoction order and decoction time of each herb in the Chinese medicine prescription and basic preparation, and select a suitable basic preparation.

[0143] The prescription splitting module 103 is used to split the traditional Chinese medicine prescription according to the selected basic preparation, and decompose it into basic preparation and added ingredients, wherein the added ingredients are one or more traditional Chinese medicine extracts or processed products that need to be added.

[0144] The dosage calculation module 104 is used to calculate the required amount of the basic preparation and the amount of one or more Chinese herbal extracts or processed products to be added based on the Chinese herbal prescription and the selected basic preparation.

[0145] The mixing and processing module 105 is used to mix the basic preparation with the required Chinese herbal extracts or processed materials to obtain a Chinese herbal preparation that conforms to the Chinese herbal prescription.

[0146] The traditional Chinese medicine formula processing system and the traditional Chinese medicine formula processing method of the present invention have corresponding technical features. Please refer to the description of the aforementioned traditional Chinese medicine formula processing method, which will not be repeated here.

[0147] This invention also provides a computer device, including a memory and a processor. The memory stores a computer program, and the processor executes the computer program to implement the steps of the traditional Chinese medicine formula processing method described above. The computer device can be a server, including a processor, memory, and a network interface connected via a system bus. The processor of the computer device provides computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and internal memory. The non-volatile storage medium stores an operating system, computer programs, and a database. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage medium. The network interface of the computer device is used to communicate with external terminals via a network connection. Those skilled in the art will understand that the structures given above are only partial structures related to the present application and do not constitute a limitation on the computer device to which the present application is applied. Specific computer devices may include more or fewer components than described above, or combine certain components, or have different component arrangements.

[0148] The computer device of the present invention corresponds one-to-one with the technical features of the traditional Chinese medicine formula processing method and the traditional Chinese medicine formula processing system of the present invention. Please refer to the description of the aforementioned traditional Chinese medicine formula processing method and the traditional Chinese medicine formula processing system, which will not be repeated here.

[0149] The present invention also provides a computer-readable storage medium storing a computer program that, when executed by a processor, implements the steps of the traditional Chinese medicine formula processing method described above.

[0150] The computer-readable storage medium of the present invention corresponds one-to-one with the technical features of the traditional Chinese medicine formula processing method and the traditional Chinese medicine formula processing system of the present invention. Please refer to the description of the aforementioned traditional Chinese medicine formula processing method and the traditional Chinese medicine formula processing system, which will not be repeated here.

[0151] In summary, the method, system, equipment, and computer-readable storage medium for processing traditional Chinese medicine formulas of the present invention can both simplify and expedite the processing of traditional Chinese medicine formulas, thereby making the use of traditional Chinese medicine convenient and quick, and also enable the chemical reactions and interactions between various medicinal materials during the decoction process, ensuring the efficacy of the processed traditional Chinese medicine and thus giving it good effectiveness and safety.

[0152] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A processing method of a traditional Chinese medicine prescription, characterized in that, The method includes: Step 1: Obtain the prescription for the Chinese herbal medicines that need to be processed; Step 2: Obtain one or more basic preparations similar to the Chinese medicine prescription, analyze the dosage, decoction method, decoction order and decoction time of each herb in the Chinese medicine prescription and basic preparations, and select a suitable basic preparation; Step 3: Based on the selected basic preparation, the traditional Chinese medicine prescription is broken down into a basic preparation and added ingredients, wherein the added ingredients are one or more traditional Chinese medicine extracts or processed products that need to be added. Step 4: Calculate the required amount of the basic preparation and the amount of one or more Chinese herbal extracts or processed products to be added; Step 5: Mix the pre-processed basic preparation with the required Chinese herbal extracts or processed products to obtain a Chinese herbal preparation that conforms to the Chinese herbal prescription.

2. The processing method of traditional Chinese medicine prescription according to claim 1, characterized in that, Step 2 also includes: By comparing the Chinese herbal medicine prescriptions with various basic preparations, the effects of differences in dosage, decoction method, decoction order, and decoction time of each herb in the Chinese herbal medicine prescriptions and various basic preparations on the medicinal properties were analyzed. Basic preparations with minimal impact on medicinal properties from the differences in various aspects compared to the Chinese herbal medicine prescriptions were selected as suitable basic preparations.

3. The processing method of the traditional Chinese medicine prescription according to claim 1, characterized in that, The method for selecting a suitable basic formulation is as follows: Traditional Chinese medicine prescription X and the basic preparation to be selected contain n herbs X1, X2, ..., Xn. W(Xi) represents the effect of the weight difference of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where Wt is the threshold for the effect of weight difference on medicinal properties. M(Xi) represents the effect of the difference in decoction method of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where Mt is the threshold for the effect of the effect of the difference in decoction method on medicinal properties. S(Xi) represents the effect of the difference in decoction order of the i-th herb in the traditional Chinese medicine prescription X and the basic preparation on the medicinal properties of the traditional Chinese medicine, where St is the threshold for the effect of ... P(X) indicates whether the basic preparation can be used as a suitable basic preparation for traditional Chinese medicine prescription X.

4. The method for processing a traditional Chinese medicine prescription according to claim 1, characterized in that, The processing method of the traditional Chinese medicine prescription also includes: comparing the traditional Chinese medicine prescription with the selected basic preparation; for drugs that are missing or insufficient in the basic preparation, supplementing the basic preparation by adding corresponding traditional Chinese medicine extracts or processed products; or for drugs that are excessive or in excess in the basic preparation, supplementing and neutralizing the basic preparation by adding corresponding traditional Chinese medicine extracts or processed products to counteract the excess drug properties.

5. A method for processing traditional Chinese medicine prescriptions according to claim 1, characterized in that, The method for selecting suitable basic preparations also includes: establishing a basic preparation selection database. This database includes the mechanism and corresponding value of each herb's effect during the decoction process in different traditional Chinese medicine prescriptions, as well as the magnitude of its effect during decoction and its corresponding value. This database is established through methods such as traditional Chinese medicine theory, clinical trials, big data analysis, and expert-based manual setting based on experience. When selecting a basic formulation, the differences between the basic formulation and the traditional Chinese medicine prescription are used to determine the amount of traditional Chinese medicine extracts or processed substances that need to be added after selecting the basic formulation, and the amount of traditional Chinese medicine extracts or processed substances that need to be added is analyzed. Based on the basic formulation selection database, the mechanism and magnitude of action of the Chinese herbal medicines (TCMs) to be added to the basic formulation during the decoction process of the TCM prescription are read. Combined with the required amount, the difference between the mixed formulation obtained by selecting the basic formulation and adding the corresponding TCM extracts or processed products and the original processing (decoction method) of the TCM prescription can be determined. The greater the difference, the higher the score of the basic formulation. The above analysis was performed on each of the candidate basic preparations, and the basic preparation with the lower comprehensive score for the original Chinese medicine prescription was selected as the suitable basic preparation. The specific calculation method is as follows: The selected basic formulation needs to contain Chinese herbal extracts or processed products Y1, Y2, ..., Yn. D(Yi) represents the amount of Yi that needs to be added, f(Yi) represents the value corresponding to the mechanism of action of Yi in the original prescription, R(Yi) represents the value corresponding to the function of Yi in the original prescription, and Q represents the comprehensive score of the basic preparation to be selected.

6. The method for processing a traditional Chinese medicine prescription according to claim 1, characterized in that: The traditional Chinese medicine formula processing method selects more than one basic preparation. Based on the traditional Chinese medicine prescription and the selected basic preparations, the required amount of each basic preparation is calculated. Then, the more than one basic preparation is mixed to obtain a traditional Chinese medicine preparation that conforms to the traditional Chinese medicine prescription. If a traditional Chinese medicine prescription requires more than one basic preparation and additional ingredients, calculate the amount of one or more traditional Chinese medicine extracts or processed products to be added, and then mix the required traditional Chinese medicine extracts or processed products with more than one basic preparation to obtain a traditional Chinese medicine preparation that conforms to the prescription.

7. A method for processing a traditional Chinese medicine prescription according to claim 1, characterized in that, The method for processing traditional Chinese medicine prescriptions also includes: establishing a basic preparation library, wherein the basic preparations are based on existing prescription data or classic prescriptions, obtained through data analysis, suitable for mass production and processing, and can be supplemented with traditional Chinese medicine extracts or processed products as needed to form basic preparations of traditional Chinese medicine that can be widely used in similar traditional Chinese medicine prescriptions.

8. A traditional Chinese medicine formula processing system, characterized in that, The system includes: a data acquisition module, a basic formulation selection module, a prescription splitting module, a dosage calculation module, and a mixing and processing module. The data acquisition module is used to acquire the Chinese medicine prescription that needs to be processed and to acquire one or more basic preparations similar to the Chinese medicine prescription; The basic preparation selection module is used to analyze the dosage, decoction method, decoction order, and decoction time of each herb in the traditional Chinese medicine prescription and basic preparation, and select a suitable basic preparation. The prescription splitting module is used to split the traditional Chinese medicine prescription according to the selected basic preparation, breaking it down into a basic preparation and added ingredients, wherein the added ingredients are one or more traditional Chinese medicine extracts or processed products that need to be added. The dosage calculation module is used to calculate the required amount of basic preparation and the amount of one or more Chinese herbal extracts or processed products to be added, based on the Chinese herbal prescription and the selected basic preparation. The mixing and processing module is used to mix the pre-processed basic preparation with the required Chinese herbal extracts or processed materials to obtain a Chinese herbal preparation that conforms to the Chinese herbal prescription.

9. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that: When the processor executes the computer program, it implements the steps of the traditional Chinese medicine formula processing method as described in any one of claims 1-8.

10. A computer-readable storage medium storing a computer program, characterized in that: When the computer program is executed by the processor, it implements the steps of the traditional Chinese medicine formula processing method as described in any one of claims 1-8.

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