ANTIGENIC PEPTIDE WITH MULTIPLE KRAS VARIANT PEPTIDES LINKED TO EACH OTHER, NUCLEIC ACID ENCODING THE SAME, AND USE OF THE ANTIGENIC PEPTIDE
Patent Information
- Application Number
- ARP20250100829
- Authority / Receiving Office
- AR · AR
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-03-29
- Filing Date
- 2025-03-28
- Publication Date
- 2026-10-07
Claims
An antigenic peptide with multiple KRAS variant peptides linked together, mRNA encoding the antigenic peptide, DNA encoding the antigenic peptide, an immunogenic composition including the antigenic peptide with multiple KRAS variant peptides linked together and the mRNA encoding the antigenic peptide, and a method for inducing an immune response against the KRAS variant peptides in a subject are provided.
1. An antigenic peptide with two or more KRAS variant peptides linked together, wherein the KRAS variant peptides are selected from the group consisting of a G12R variant peptide, a G12D variant peptide, a G12C variant peptide, a G12V variant peptide, a G12A variant peptide, a G13D variant peptide, a Q61H variant peptide, a Q61R variant peptide, a Q61K variant peptide, a Q61L variant peptide, and an A146T variant peptide.
13. An immunogenic composition comprising the antigenic peptide of any one of claims 1 to 10, or mRNA encoding the antigenic peptide.