Method for manufacturing selenium-rich fucoidin

Abstract

The invention discloses a method for manufacturing selenium-rich fucoidin, which comprises the steps: food grade fucoidin solution made by edible seaweed is processed by selenizing agent under the acidic condition, and then is hyperfiltrated and separated to remove inorganic selenium, so that the selenium-rich fucoidin is manufactured. Selenium-rich fucoidin is manufactured by the method so that selenium content can be effectively controlled, and the selenium-rich fucoidin does not contain the inorganic selenium, thus avoiding the harm brought by the inorganic selenium.

Description

technical field

[0001] The invention discloses a method for producing selenium-enriched fucoidan. Background technique

[0002] The necessity and toxicity of selenium are well known, but the toxicity of inorganic selenium is relatively high, and the dosage of its toxicity and physiological activity is roughly equivalent, thus greatly limiting its application. The toxicity of organic selenium is relatively low. Some data show that the toxicity of inorganic selenium is 2.94 times that of organic selenium. Therefore, many people are currently developing various organic selenium compounds through various methods, such as biotransformation and chemical addition. Various selenium-enriched products, such as selenium-enriched yeast, selenium-enriched tea, selenized carrageenan and other products. But selenium supplementation should have strict dose limitation, even its content of organic selenides is not the more the better, and the selenium-enriched sulfate fucoidan produced by th...

Examples

Embodiment approach 1

[0015] Take 30g of edible grade fucoidan sulfate, make it into 10% aqueous solution, add Na 2 SeO 3 20g, HCl15ml, add selenizing agent at a constant temperature of 80°C, react for 24 hours, centrifuge to remove a small amount of insoluble matter, use a membrane device with a molecular weight cut-off of 20,000 for ultrafiltration, and check the inorganic selenium in the effluent at any time until it is confirmed that it does not exist As far as inorganic selenium is concerned, selenium-enriched fucoidan with a selenium content of 0.45% is obtained.

Embodiment approach 2

[0017] Take 30g of edible grade fucoidan sulfate, make it into 10% aqueous solution, add Na 2 SeO 3 20g, HNO 3 15ml, add selenizing agent at a constant temperature of 80°C, react for 24 hours, centrifuge to remove a small amount of insoluble matter, use a membrane device with a molecular weight cut-off of 20,000 for ultrafiltration, and check the inorganic selenium in the effluent at any time until it is confirmed that there is no inorganic selenium So far, the selenium-enriched fucoidan with a selenium content of 0.36% has been obtained.

Embodiment approach 3

[0019] Take 30g of edible grade fucoidan sulfate, make it into 10% aqueous solution, add Na 2 SeO 3 15g, HCl and 15ml of acetic acid, add selenizing agent at a constant temperature of 80°C, react for 24 hours, centrifuge to remove a small amount of insoluble matter, use a membrane device with a molecular weight cut-off of 20,000 for ultrafiltration, and detect the inorganic selenium in the effluent at any time until Until it is confirmed that there is no inorganic selenium, the selenium-enriched fucoidan with a selenium content of 0.45% is obtained.

technical field

[0001] The invention discloses a method for producing selenium-enriched fucoidan. Background technique

[0002] The necessity and toxicity of selenium are well known, but the toxicity of inorganic selenium is relatively high, and the dosage of its toxicity and physiological activity is roughly equivalent, thus greatly limiting its application. The toxicity of organic selenium is relatively low. Some data show that the toxicity of inorganic selenium is 2.94 times that of organic selenium. Therefore, many people are currently developing various organic selenium compounds through various methods, such as biotransformation and chemical addition. Various selenium-enriched products, such as selenium-enriched yeast, selenium-enriched tea, selenized carrageenan and other products. But selenium supplementation should have strict dose limitation, even its content of organic selenides is not the more the better, and the selenium-enriched sulfate fucoidan produced by th...

Examples

Embodiment approach 1

[0015] Take 30g of edible grade fucoidan sulfate, make it into 10% aqueous solution, add Na 2 SeO 3 20g, HCl15ml, add selenizing agent at a constant temperature of 80°C, react for 24 hours, centrifuge to remove a small amount of insoluble matter, use a membrane device with a molecular weight cut-off of 20,000 for ultrafiltration, and check the inorganic selenium in the effluent at any time until it is confirmed that it does not exist As far as inorganic selenium is concerned, selenium-enriched fucoidan with a selenium content of 0.45% is obtained.

Embodiment approach 2

[0017] Take 30g of edible grade fucoidan sulfate, make it into 10% aqueous solution, add Na 2 SeO 3 20g, HNO 3 15ml, add selenizing agent at a constant temperature of 80°C, react for 24 hours, centrifuge to remove a small amount of insoluble matter, use a membrane device with a molecular weight cut-off of 20,000 for ultrafiltration, and check the inorganic selenium in the effluent at any time until it is confirmed that there is no inorganic selenium So far, the selenium-enriched fucoidan with a selenium content of 0.36% has been obtained.

Embodiment approach 3

[0019] Take 30g of edible grade fucoidan sulfate, make it into 10% aqueous solution, add Na 2 SeO 3 15g, HCl and 15ml of acetic acid, add selenizing agent at a constant temperature of 80°C, react for 24 hours, centrifuge to remove a small amount of insoluble matter, use a membrane device with a molecular weight cut-off of 20,000 for ultrafiltration, and detect the inorganic selenium in the effluent at any time until Until it is confirmed that there is no inorganic selenium, the selenium-enriched fucoidan with a selenium content of 0.45% is obtained.