Intelligent aquagel based on cyclodextrin functional groups, and preparation method and application thereof

Abstract

The invention belongs to the technical field of intelligent aquagels, and discloses an intelligent aquagel based on cyclodextrin functional groups, and a preparation method and application thereof. The intelligent aquagel based on cyclodextrin functional groups is prepared by carrying out crosslinking polymerization reaction on previously prepared double-bond modified cyclodextrin and N-isopropyl acrylamide as polymerizable monomers by using N,N- methylene-bis-acrylamide, polyethyleneglycol bis(methyl)acrylate or polycaprolac-bis(methyl)acrylate as a crosslinking agent under the initiation of azodiisobutyl cyanogen. The cyclodextrin functional components containing special cavity structure are introduced to improve the swelling and deswelling dynamics of the aquagel, so that the response speed of the prepared aquagel is obviously enhanced. The aquagel can be used in the fields of drug controlled release and other biomedicines.

Description

technical field

[0001] The invention belongs to the technical field of intelligent hydrogel, and in particular relates to an intelligent hydrogel based on a cyclodextrin functional group and its preparation method and application. Background technique

[0002] Hydrogels are polymers with three-dimensional crosslinked or interpenetrating networks that can swell in water and absorb large amounts of water without dissolving them. According to the response of hydrogels to external environmental stimuli, they can be divided into traditional hydrogels and intelligent hydrogels. Among them, intelligent hydrogels can also be called stimulus-responsive or sensitive hydrogels. Environmental stimuli can produce hydrogels that respond to environmental stimuli, that is, to a considerable extent, they can sense, process and perform work in response to environmental microphysicochemical stimuli, such as temperature, electric field, magnetic field, light, pH, ionic strength, pressure, etc. ...

Examples

Embodiment 1

[0047] A method for preparing a poly(N-isopropylacrylamide) smart hydrogel based on cyclodextrin functional groups in this embodiment, the specific preparation steps are as follows:

[0048] Weigh 0.4g of N-isopropylacrylamide (NIPAAm), 20mg of GCD and 32mg of BIS, dissolve in 4ml of dimethyl sulfoxide, mix the raw materials uniformly by ultrasonication for 15min, then add 10mg of azobisisobutylcyanide, and then mix thoroughly by ultrasonication for 15min before freezing Thaw cycle to remove oxygen, react at 60°C for 24 hours under the protection of nitrogen, crush the reactor, soak the gel in distilled water for a week, change the water every day, remove unreacted raw materials and obtain poly(N-iso Propylacrylamide) smart hydrogel, cut into 10mm*5mm cylindrical small pieces for later use, recorded as P(NIPAAm-co-GCD) 1 .

Embodiment 2

[0050] A method for preparing a poly(N-isopropylacrylamide) smart hydrogel based on cyclodextrin functional groups in this embodiment, the specific preparation steps are as follows:

[0051] Weigh 0.4g of N-isopropylacrylamide (NIPAAm), 40mg of GCD and 32mg of BIS, dissolve it in 4ml of dimethyl sulfoxide, mix the raw materials uniformly by ultrasonication for 15min, then add 10mg of azobisisobutylcyanide, and then mix thoroughly by ultrasonication for 15min before freezing Thaw cycle to remove oxygen, react at 60°C for 24 hours under the protection of nitrogen, crush the reactor, soak the gel in distilled water for a week, change the water every day, remove unreacted raw materials and obtain poly(N-iso Propylacrylamide) smart hydrogel, cut into 10mm*5mm cylindrical small pieces for later use, recorded as P(NIPAAm-co-GCD) 2 .

Embodiment 3

[0053] A method for preparing a poly(N-isopropylacrylamide) smart hydrogel based on cyclodextrin functional groups in this embodiment, the specific preparation steps are as follows:

[0054] Weigh 0.4g of N-isopropylacrylamide (NIPAAm), 60mg of GCD and 32mg of BIS and dissolve it in 4ml of dimethyl sulfoxide, mix the raw materials uniformly by ultrasonication for 15min, then add 10mg of azobisisobutylcyanide, and then 15min of ultrasonication to fully mix and freeze Thaw cycle to remove oxygen, react at 60°C for 24 hours under the protection of nitrogen, crush the reactor, soak the gel in distilled water for a week, change the water every day, remove unreacted raw materials and obtain poly(N-iso Propylacrylamide) smart hydrogel, cut into 10mm*5mm cylindrical small pieces for later use, recorded as P(NIPAAm-co-GCD) 3 .

technical field

[0001] The invention belongs to the technical field of intelligent hydrogel, and in particular relates to an intelligent hydrogel based on a cyclodextrin functional group and its preparation method and application. Background technique

[0002] Hydrogels are polymers with three-dimensional crosslinked or interpenetrating networks that can swell in water and absorb large amounts of water without dissolving them. According to the response of hydrogels to external environmental stimuli, they can be divided into traditional hydrogels and intelligent hydrogels. Among them, intelligent hydrogels can also be called stimulus-responsive or sensitive hydrogels. Environmental stimuli can produce hydrogels that respond to environmental stimuli, that is, to a considerable extent, they can sense, process and perform work in response to environmental microphysicochemical stimuli, such as temperature, electric field, magnetic field, light, pH, ionic strength, pressure, etc. ...

Examples

Embodiment 1

[0047] A method for preparing a poly(N-isopropylacrylamide) smart hydrogel based on cyclodextrin functional groups in this embodiment, the specific preparation steps are as follows:

[0048] Weigh 0.4g of N-isopropylacrylamide (NIPAAm), 20mg of GCD and 32mg of BIS, dissolve in 4ml of dimethyl sulfoxide, mix the raw materials uniformly by ultrasonication for 15min, then add 10mg of azobisisobutylcyanide, and then mix thoroughly by ultrasonication for 15min before freezing Thaw cycle to remove oxygen, react at 60°C for 24 hours under the protection of nitrogen, crush the reactor, soak the gel in distilled water for a week, change the water every day, remove unreacted raw materials and obtain poly(N-iso Propylacrylamide) smart hydrogel, cut into 10mm*5mm cylindrical small pieces for later use, recorded as P(NIPAAm-co-GCD) 1 .

Embodiment 2

[0050] A method for preparing a poly(N-isopropylacrylamide) smart hydrogel based on cyclodextrin functional groups in this embodiment, the specific preparation steps are as follows:

[0051] Weigh 0.4g of N-isopropylacrylamide (NIPAAm), 40mg of GCD and 32mg of BIS, dissolve it in 4ml of dimethyl sulfoxide, mix the raw materials uniformly by ultrasonication for 15min, then add 10mg of azobisisobutylcyanide, and then mix thoroughly by ultrasonication for 15min before freezing Thaw cycle to remove oxygen, react at 60°C for 24 hours under the protection of nitrogen, crush the reactor, soak the gel in distilled water for a week, change the water every day, remove unreacted raw materials and obtain poly(N-iso Propylacrylamide) smart hydrogel, cut into 10mm*5mm cylindrical small pieces for later use, recorded as P(NIPAAm-co-GCD) 2 .

Embodiment 3

[0053] A method for preparing a poly(N-isopropylacrylamide) smart hydrogel based on cyclodextrin functional groups in this embodiment, the specific preparation steps are as follows:

[0054] Weigh 0.4g of N-isopropylacrylamide (NIPAAm), 60mg of GCD and 32mg of BIS and dissolve it in 4ml of dimethyl sulfoxide, mix the raw materials uniformly by ultrasonication for 15min, then add 10mg of azobisisobutylcyanide, and then 15min of ultrasonication to fully mix and freeze Thaw cycle to remove oxygen, react at 60°C for 24 hours under the protection of nitrogen, crush the reactor, soak the gel in distilled water for a week, change the water every day, remove unreacted raw materials and obtain poly(N-iso Propylacrylamide) smart hydrogel, cut into 10mm*5mm cylindrical small pieces for later use, recorded as P(NIPAAm-co-GCD) 3 .

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