Gene sequencing chip and gene sequencing device

A gene sequencing and chip technology, used in biochemical cleaning devices, enzymology/microbiology devices, and microbial determination/inspection, etc., can solve the problems of large loss of flow channel materials, large flow channel depth, and low unit throughput. , to achieve the effect of high assembly production efficiency, eliminating bubble impurities and ensuring data throughput

CN110387321AActive Publication Date: 2019-10-29MGI TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2019-10-29

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Abstract

The invention provides a gene sequencing chip. According to the gene sequencing chip, grooves are formed in a cover, and 4 channels or 2 channels are formed between the grooves and a silicon chip, sothat the unit flux is high; the silicon chip is provided with a plurality of reaction chambers, each reaction chamber can capture and fix a DNA molecule, so that the DNA molecule cannot move along with fluid, and high-flux optical sequencing is realized; the 4-channel chip not only can guarantee data flux and save cost, but also can separately load different test piece samples, and can meet the applications of complete genome sequencing, complete exon sequencing, transcriptome sequencing and the like; the test piece consumption and the reagent consumption of the 2-channel chip are reduced by half, so that the 2-channel chip can be used for quick detection of small and short test pieces; and besides, own positioning holes and a clamping hole protecting frame are arranged on the periphery ofthe chip, so that the chip can be accurately positioned, a clamping hole can also be stretched to enable the protecting frame to be in micro deformation, and the chip is convenient to load; and the assembling production efficiency is high, and the gene sequencing chip is suitable for batch large-scale production.
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Description

technical field

[0001] The invention relates to the technical field of gene sequencing, in particular to a gene sequencing chip and a gene sequencing device. Background technique

[0002] With the development of gene sequencing technology, the second-generation sequencing technology, which performs continuous cycles of chemical reactions such as fluorescent labeling, fluorescent imaging, deblocking, and removal of fluorophores, has been widely used in whole genome sequencing. Transcriptome sequencing, metagenomic sequencing, etc., the corresponding sequencing platforms and products are constantly changing. As an important device in the process of sequencing the base sequence of specific DNA fragments, the gene sequencing chip is moving towards high-throughput and low-cost driven by sequencing technology. Rapid development.

[0003] Traditional sequencing chips are usually equipped with a large overall liquid flow channel, which requires a large amount of DNA molecule sample...

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Embodiment Construction

[0046] In order to more clearly understand the above objects, features and advantages of the embodiments of the present invention, the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be noted that, in the case of no conflict, the features in the embodiments of the present application may be combined with each other.

[0047] In the following description, many specific details are set forth in order to fully understand the embodiments of the present invention, and the described implementations are only part of the implementations of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the embodiments of the present invention.

[0048]It should be noted that the "flow channel" and "channel" in thi...