Tumor localization device

Abstract

The present invention provides a tumor in vitro positioning puncture device, which includes: a fixed plate, at least three fixed needles, two graduated needles and a slider, wherein the at least three fixed needles and the two graduated needles are vertically fixed on the fixed plate, and the slider is provided with a guide hole for accommodating a biopsy needle and a slide hole for accommodating two graduated needles, wherein the axis of the guide hole is perpendicular to the axis of the slide hole. The position of the tumor can be fixed by at least three fixed needles, and the three-dimensional coordinates of the tumor (i.e., the coordinates of the tumor puncture sampling are determined) can be obtained by combining the cooperation of the two graduated needles, the slider and the biopsy needle, so as to accurately locate the tumor in vitro, and a tumor specimen at a specific position can be obtained by combining the positioning information of the imaging examination, and molecular level information corresponding to the imaging examination can be obtained by genetic testing, laying a foundation for subsequent precise imaging research.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to an in vitro tumor positioning device. Background Art

[0002] At present, multi-parameter MRI, PET or CT examinations can reflect the differences in different properties or metabolism in the same solid tumor, but there is no good solution to the problem of positioning compared with pathological and molecular detection. Clinically, it has been found that the heterogeneity of tumors is very obvious through multi-point sampling, but the sampling is random and cannot correspond to the imaging data, which creates an insurmountable gap between imaging examinations and cell and molecular examinations.

[0003] With regard to the problem that cell and molecular examinations in the prior art cannot achieve a one-to-one correspondence with imaging examinations, those skilled in the art have been looking for solutions. Summary of the invention

[0004] The purpose of the present invention is to provide an in vitro tumor localization device to solve the problem that molecular examinations in the prior art cannot correspond to imaging examinations, resulting in the inability to predict tumor genetic mutations or expression variations or therapeutic responses to optional drugs through imaging examinations, thereby achieving accurate diagnosis and treatment.

[0005] In order to solve the above technical problems, the present invention provides an in vitro tumor positioning device, which includes: a fixed plate, at least three fixed needles, two scale needles and a slider, the at least three fixed needles and the two scale needles are vertically fixed on the fixed plate, and the slider is provided with a guide hole for accommodating a biopsy needle and a sliding hole for accommodating two scale needles, and the axis of the guide hole is perpendicular to the axis of the sliding hole.

[0006] In the tumor positioning device, each fixing needle comprises a needle rod and a base, and the base is fixedly connected to the root of the needle rod.

[0007] In the tumor localization device, the cross section of the needle rod is I-shaped.

[0008] In the tumor localization device, each scale needle comprises a scale rod and a base, and the base is fixedly connected to the root of the scale rod.

[0009] In the tumor positioning device, the fixing plate includes a first fixing plate and a second fixing plate arranged parallel to the first fixing plate, the base of the fixing needle and the base of the scale needle are both clamped by the first fixing plate and the second fixing plate, and the needle rod and the scale rod both pass through the second fixing plate; the second fixing plate has two mutually parallel sliding grooves, and each scale rod can slide along a sliding groove.

[0010] In the tumor positioning device, the first fixing plate and the second fixing plate are fixedly connected by at least two screws.

[0011] In the tumor localization device, three of the at least three fixing needles are evenly distributed at equal intervals.

[0012] In the tumor localization device, the at least three fixing needles are fixed on a predetermined area of ​​the fixing plate, and the two scale needles are fixed on the fixing plate adjacent to the predetermined area.

[0013] The tumor localization device also includes a biopsy needle, which is accommodated in the guide hole.

[0014] In the tumor localization device provided by the present invention, the tumor localization device includes: a fixed plate, at least three fixed needles, two graduated needles and a slider, the at least three fixed needles and the two graduated needles are vertically fixed on the fixed plate, the slider is provided with a guide hole for accommodating a biopsy needle and a slide hole for accommodating two graduated needles, and the axis of the guide hole is perpendicular to the axis of the slide hole. The position of the tumor can be fixed by at least three fixed needles, and the three-dimensional coordinates of the tumor (i.e., the coordinates of the tumor puncture sampling are determined) are obtained by combining the cooperation of the two graduated needles, the slider and the biopsy needle, thereby improving the accuracy of tumor localization, enabling molecular examination to correspond to imaging examination, and improving the diagnosis and treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 is a schematic structural diagram of a tumor localization device in one embodiment of the present invention;

[0016] Figure 2 is a schematic diagram of the structure of a fixing needle in a tumor localization device in one embodiment of the present invention;

[0017] Figure 3 is a schematic diagram of the structure of a graduated needle in a tumor localization device in one embodiment of the present invention;

[0018] Figure 4 is a schematic structural diagram of a slider in a tumor localization device in one embodiment of the present invention;

[0019] Figure 5 is a schematic structural diagram of a first fixing plate in a tumor localization device in one embodiment of the present invention;

[0020] Figure 6 It is a schematic diagram of the structure of the second fixing plate in the tumor positioning device in one embodiment of the present invention.

[0021] In the figure, 1-fixed plate; 11-first fixed plate; 12-second fixed plate; 2-fixed needle; 21-needle rod; 22, 33-base; 3-scale needle; 31-scale rod; 4-slider; 41-guide hole; 42-slide hole; 5-biopsy needle. DETAILED DESCRIPTION

[0022] The tumor localization device proposed in the present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. The advantages and features of the present invention will become clearer according to the following description and claims. It should be noted that the drawings are all in a very simplified form and are not in precise proportions, and are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the present invention.

[0023] Please refer to Figure 1 and Figure 4 , Figure 1 is a schematic structural diagram of the tumor localization device of the present invention; Figure 4 FIG. 1 is a schematic diagram of the structure of a slider in a tumor localization device according to an embodiment of the present invention. Figure 1 and Figure 4 As shown, the tumor localization device comprises: a fixing plate 1, at least three fixing needles 2, two scale needles 3 and a slider 4, wherein the at least three fixing needles 2 and the two scale needles 3 are vertically fixed on the fixing plate 1, and the slider 4 is provided with a guide hole 41 for accommodating the biopsy needle 5 and a slide hole 42 for accommodating the two scale needles 3, wherein the axis of the guide hole 41 is perpendicular to the axis of the slide hole 42. In this embodiment, there are two slide holes 42 on the slider 4, and the slider 4 is sleeved on the two scale needles and can slide along the axial direction of the scale needles 3.

[0024] like Figure 4 As shown, the tumor positioning device further includes a biopsy needle 5 , and the biopsy needle 5 is accommodated in the guide hole 41 .

[0025] In order to better stabilize the position of the tumor, three of the at least three fixing needles 2 are evenly distributed at equal intervals to form a plane. When used, the tumor is inserted on the at least three fixing needles 2.

[0026] In order to facilitate the acquisition of the positioning coordinates of the tumor, the at least three fixing needles 2 are fixed on the predetermined area of ​​the fixing plate 1, and the two scale needles 3 are fixed on the fixing plate 1 adjacent to the predetermined area, so that the two scale needles 3 can measure the coordinates of the tumor inserted on the at least three fixing needles 2.

[0027] Please refer to Figure 2 , which is a schematic diagram of the structure of the fixing needle 2 in the tumor localization device in one embodiment of the present invention. Figure 2As shown, each fixing needle 2 includes a needle rod 21 and a base 22, and the base 22 is fixedly connected to the root of the needle rod 21. Preferably, the cross section of the needle rod 21 is an I-shaped, so as to prevent the tumor from rotating and increase stability; the base 22 is used to ensure that it is perpendicular to the fixing plate 1 after being fixed to the fixing plate 1.

[0028] Please refer to Figure 3 , which is a schematic diagram of the structure of a graduated needle in a tumor localization device in one embodiment of the present invention. Figure 3 As shown, each scale needle 3 includes a scale rod 31 and a base 33 , and the base 33 is fixedly connected to the root of the scale rod 31 .

[0029] Please refer to Figure 1 , Figure 5 and Figure 6 , Figure 5 is a schematic structural diagram of a first fixing plate in a tumor localization device in one embodiment of the present invention; Figure 6 FIG. 1 is a schematic diagram of the structure of the second fixing plate 12 in the tumor positioning device in one embodiment of the present invention. Figure 1 , Figure 5 and Figure 6 As shown, the fixing plate 1 includes a first fixing plate 11 and a second fixing plate 12 arranged parallel to the first fixing plate 11, the base 22 of the fixing needle 2 and the base 33 of the scale needle 3 are clamped by the first fixing plate 11 and the second fixing plate 12, and the needle rod 21 and the scale rod 31 pass through the second fixing plate 12; the second fixing plate 12 has two parallel sliding grooves, and each scale rod 31 can slide along a sliding groove. The first fixing plate 11 and the second fixing plate 12 are fixedly connected by at least two screws. Figure 1 As shown, in this embodiment, the first fixing plate 11 and the second fixing plate 12 are fixedly connected by four screws, and each screw passes through a threaded hole at a corner of the first fixing plate 11 and the second fixing plate 12 to fix the two.

[0030] In actual tumor localization applications, please combine Figure 1 The method of using the tumor localization device of the present invention is described by taking the number of the fixed needles 2 as three as an example:

[0031] The first step is to select three fixing needles 2 and two scale needles 3 of appropriate sizes according to the size of the tumor and fix them on the fixing plate 1;

[0032] In the second step, the tumor is inserted into three fixing needles 2, and longitudinal and transverse photographs (i.e., pathological photographs) are taken to obtain the two-dimensional size of the tumor;

[0033] The third step is to fit the three-dimensional model generated by MRI or CT and the pathological photographs to determine the sampling points to be selected;

[0034] Step 4: adjust the positions of the two scale needles 3 on the second fixed plate 12 according to the coordinates of the sampling point to determine the horizontal coordinate (i.e., the first axis coordinate); adjust the position of the slider 4 to determine the vertical coordinate (i.e., the second axis coordinate);

[0035] Step 5: Use the 18G BARD disposable puncture biopsy gun (or other types of puncture biopsy guns), put the biopsy needle 5 into the guide hole 41 of the slider 4, make the tip of the biopsy needle 5 close to the tumor, and determine the third axis coordinate according to the scale on the puncture biopsy gun. At this time, the puncture biopsy gun can be activated to take samples.

[0036] This device solves the problem of linkage between imaging examination and pathological molecular diagnosis by three-dimensionally locating tumors in vitro and puncturing samples with determined coordinates. In other words, through in vitro positioning puncture, pathological sections or fresh tissues corresponding to MRI examination signals or CT signals are obtained for common pathological tests or genetic tests. Based on the correlation analysis of genetic test data and imaging parameters, a prediction model is obtained. After the model is established, when the imaging results are obtained, the molecular mutation of subsequent patients can be predicted, thereby guiding treatment decisions.

[0037] In summary, in the tumor localization device provided by the present invention, the tumor localization device includes: a fixed plate, at least three fixed needles, two graduated needles and a slider, the at least three fixed needles and the two graduated needles are vertically fixed on the fixed plate, the slider is provided with a guide hole for accommodating a biopsy needle and a slide hole for accommodating two graduated needles, and the axis of the guide hole is perpendicular to the axis of the slide hole. The position of the tumor can be fixed by at least three fixed needles, and the three-dimensional coordinates of the tumor (i.e., the coordinates of the tumor puncture sampling are determined) are obtained by combining the cooperation of the two graduated needles, the slider and the biopsy needle, thereby improving the accuracy of tumor localization, enabling molecular examination to correspond to imaging examination, and improving the diagnosis and treatment effect.

[0038] The above description is only a description of the preferred embodiments of the present invention, and is not intended to limit the scope of the present invention. Any changes or modifications made by a person skilled in the art in the field of the present invention based on the above disclosure shall fall within the scope of protection of the claims.

Claims

1. A tumor in vitro positioning device, characterized in that: include: A fixed plate, at least three fixed needles, two scale needles and a slider, wherein the at least three fixed needles and the two scale needles are vertically fixed to the fixed plate, the slider is provided with a guide hole for accommodating a biopsy needle and a slide hole for accommodating two scale needles, the axis of the guide hole is perpendicular to the axis of the slide hole; each fixed needle comprises a needle rod and a base, the base is fixedly connected to the root of the needle rod; the cross section of the needle rod is an I-shaped; each scale needle comprises a scale rod and a base, the base is fixedly connected to the root of the scale rod; the fixed plate comprises a first fixed plate and a second fixed plate arranged parallel to the first fixed plate, a fixed The base of the needle and the base of the scale needle are both clamped by the first fixing plate and the second fixing plate, and the needle rod and the scale rod both pass through the second fixing plate; the second fixing plate has two parallel sliding grooves, and each scale rod can slide along a sliding groove; the first fixing plate and the second fixing plate are fixedly connected by at least two screws; three of the at least three fixing needles are evenly distributed at equal intervals; the at least three fixing needles are fixed on a predetermined area of ​​the fixing plate, and the two scale needles are fixed on the fixing plate adjacent to the predetermined area; a biopsy needle is also included, and the biopsy needle is accommodated in the guide hole; When there are three fixing needles, the method of using the tumor localization device is as follows: The first step is to select three fixing needles and two calibrated needles of appropriate sizes according to the size of the tumor and fix them on the fixing plate; In the second step, three fixation needles were inserted into the tumor, and longitudinal and transverse photographs were taken to obtain the two-dimensional size of the tumor; The third step is to fit the three-dimensional model generated by MRI or CT and the pathological photograph to determine the sampling points to be selected; Step 4: adjust the positions of the two scale needles on the second fixed plate according to the coordinates of the sampling point to determine the horizontal coordinate; adjust the position of the slider to determine the vertical coordinate; Step 5: Use the 18G BARD disposable puncture biopsy gun to place the biopsy needle into the guide hole of the slider so that the tip of the biopsy needle is close to the tumor. Determine the third axis coordinate according to the scale on the puncture biopsy gun. At this point, the puncture biopsy gun can be activated to take samples.

Images