Decoquinate microcapsules and preparation method thereof

Abstract

The invention belongs to the field of poultry coccidiostat, and discloses decoquinate microcapsules which comprise decoquinate, radix dichroa extract, sweet wormwood herb extract and astragalus extract. The decoquinate microcapsules also comprise the following components: an emulsifier and a suspending aid. The decoquinate microcapsules disclosed by the invention have the advantages of reasonableproportion, simple preparation, convenience in operation, good content uniformity of effective components, good stability, high yield and good taste, and also have slow release effect. The decoquinatemicrocapsules are a broad-spectrum coccidiostat, the anticoccidial effect can be improved by adding the radix dichroa extract and the sweet wormwood herb extract, synergistic effect is achieved, thedrug resistance on decoquinate is reduced, and the anticoccidial effect is improved.

Description

technical field

[0001] The invention relates to the field of poultry anticoccidiostats, in particular to a decoquinate microcapsule and a preparation method thereof. Background technique

[0002] Chicken coccidiosis is a very harmful intestinal parasitic protozoan disease. On the one hand, it causes huge economic losses to the chicken industry; on the other hand, it affects human food sources and health. Therefore, chicken coccidiosis is highly valued by people always, and people have invested a large amount of manpower and material resources in research and prevention and treatment.

[0003] Chicken coccidia is a parasite with a global distribution. It can almost be said that wherever chickens are raised, there are chicken coccidia. No matter how advanced the chicken farm equipment and management technology are, how strict the epidemic prevention measures are, chicken coccidiosis still occurs, not to mention the places with backward facilities and management. The main r...

Examples

Embodiment 1

[0034] A decoquinate microcapsule prepared from the following raw materials in mass percent:

[0035] Table 1

[0036]

[0037] A preparation method of decoquinate microcapsules, comprising the following steps:

[0038] 1) Add PEG4000 and PEG6000 into the Astragalus extract, stir for 30 minutes, and heat to 80°C;

[0039] 2) Cool down to 70°C, add decoquinate, Radix Changshan extract, Artemisia annua extract and hydroxypropyl methylcellulose, stir, keep warm and emulsify at 70°C for 20 minutes to obtain a mixture;

[0040] 3) Add the mixture to a spray condensation granulator with a rotating speed of 350r / min for granulation, and sieve to obtain decoquinate microcapsules with a particle size of 200 μm-850 μm.

Embodiment 2

[0042] A decoquinate microcapsule prepared from the following raw materials in mass percent:

[0043]

[0044] A preparation method of decoquinate microcapsules, comprising the following steps:

[0045] 1) Add PEG4000 and PEG6000 into the Astragalus extract, stir for 30 minutes, and heat to 80°C;

[0046] 2) Cool down to 70°C, add decoquinate, Radix Changshan extract, Artemisia annua extract and hydroxypropyl methylcellulose, stir, keep warm and emulsify at 70°C for 20 minutes to obtain a mixture;

[0047] 3) Add the mixture to a spray condensation granulator with a rotating speed of 350r / min for granulation, and sieve to obtain decoquinate microcapsules with a particle size of 200 μm-850 μm.

Embodiment 3

[0049] A decoquinate microcapsule prepared from the following raw materials in mass percent:

[0050]

[0051]

[0052] A preparation method of decoquinate microcapsules, comprising the following steps:

[0053] 1) Add PEG4000 and PEG6000 to the extract of Astragalus membranaceus, stir for 30 minutes, and heat to 80°C;

[0054] 2) Cool down to 70°C, add decoquinate, Radix Changshan extract, Artemisia annua extract and hydroxypropyl methylcellulose, stir, keep warm and emulsify at 70°C for 20 minutes to obtain a mixture;

[0055] 3) Add the mixture to a spray condensation granulator with a rotational speed of 350r / min for granulation, and sieve to obtain decoquinate microcapsules with a particle size of 200 μm-850 μm.

technical field

[0001] The invention relates to the field of poultry anticoccidiostats, in particular to a decoquinate microcapsule and a preparation method thereof. Background technique

[0002] Chicken coccidiosis is a very harmful intestinal parasitic protozoan disease. On the one hand, it causes huge economic losses to the chicken industry; on the other hand, it affects human food sources and health. Therefore, chicken coccidiosis is highly valued by people always, and people have invested a large amount of manpower and material resources in research and prevention and treatment.

[0003] Chicken coccidia is a parasite with a global distribution. It can almost be said that wherever chickens are raised, there are chicken coccidia. No matter how advanced the chicken farm equipment and management technology are, how strict the epidemic prevention measures are, chicken coccidiosis still occurs, not to mention the places with backward facilities and management. The main r...

Examples

Embodiment 1

[0034] A decoquinate microcapsule prepared from the following raw materials in mass percent:

[0035] Table 1

[0036]

[0037] A preparation method of decoquinate microcapsules, comprising the following steps:

[0038] 1) Add PEG4000 and PEG6000 into the Astragalus extract, stir for 30 minutes, and heat to 80°C;

[0039] 2) Cool down to 70°C, add decoquinate, Radix Changshan extract, Artemisia annua extract and hydroxypropyl methylcellulose, stir, keep warm and emulsify at 70°C for 20 minutes to obtain a mixture;

[0040] 3) Add the mixture to a spray condensation granulator with a rotating speed of 350r / min for granulation, and sieve to obtain decoquinate microcapsules with a particle size of 200 μm-850 μm.

Embodiment 2

[0042] A decoquinate microcapsule prepared from the following raw materials in mass percent:

[0043]

[0044] A preparation method of decoquinate microcapsules, comprising the following steps:

[0045] 1) Add PEG4000 and PEG6000 into the Astragalus extract, stir for 30 minutes, and heat to 80°C;

[0046] 2) Cool down to 70°C, add decoquinate, Radix Changshan extract, Artemisia annua extract and hydroxypropyl methylcellulose, stir, keep warm and emulsify at 70°C for 20 minutes to obtain a mixture;

[0047] 3) Add the mixture to a spray condensation granulator with a rotating speed of 350r / min for granulation, and sieve to obtain decoquinate microcapsules with a particle size of 200 μm-850 μm.

Embodiment 3

[0049] A decoquinate microcapsule prepared from the following raw materials in mass percent:

[0050]

[0051]

[0052] A preparation method of decoquinate microcapsules, comprising the following steps:

[0053] 1) Add PEG4000 and PEG6000 to the extract of Astragalus membranaceus, stir for 30 minutes, and heat to 80°C;

[0054] 2) Cool down to 70°C, add decoquinate, Radix Changshan extract, Artemisia annua extract and hydroxypropyl methylcellulose, stir, keep warm and emulsify at 70°C for 20 minutes to obtain a mixture;

[0055] 3) Add the mixture to a spray condensation granulator with a rotational speed of 350r / min for granulation, and sieve to obtain decoquinate microcapsules with a particle size of 200 μm-850 μm.

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