Multi-channel Micro-quantification System for Hematology Analyzer

By introducing a ceramic blood separation valve and rotary valve sheet mechanism into the blood cell analyzer, the rapid separation and quantitative distribution of five-channel blood samples is achieved, and the problems of long detection time and fewer types in the prior art are solved, which improves detection efficiency and reduces cross-contamination.

CN111175091BActive Publication Date: 2025-07-08URIT MEDICAL ELECTRONICS CO LTD
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Patent Information

Application Number
CN202010186586.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2020-03-17
Publication Date
2025-07-08
Estimated Expiration
2040-03-17

AI Technical Summary

Technical Problem

The existing blood cell analytical instruments have a long detection time in the five-category detection and have fewer detection types, so multi-channel detection cannot be completed in a short time.

Method used

The front cover of the ceramic blood separation valve, the ceramic blood separation valve back cover, the rotary valve plate mechanism and the five-channel micro-quantitative blood separation valve are adopted to achieve blood samples separation and quantitative distribution in five channels through rotation switching. Combined with the sampling and quantitative sensor and the liquid sensor, we ensure that the sample is quantified and cleaned without residue.

Benefits of technology

It realizes blood testing of five channels within the same time, shortens the detection time, increases the detection types, and reduces cross-contamination and sample residues, saving time and economic costs of medical units.

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Abstract

The present invention discloses a multi-channel micro-quantification system for a blood cell analyzer, which includes a front cover of a ceramic blood distribution valve, a ceramic shunt plate, a rear cover of the ceramic blood distribution valve, a rotary valve plate mechanism, and a five-channel micro-quantification blood distribution valve. The front cover of the ceramic blood distribution valve is rotatably connected to the ceramic shunt plate. The rear cover of the ceramic blood distribution valve is rotatably connected to the ceramic shunt plate and is located on the side away from the front cover of the ceramic blood distribution valve. The rotary valve plate mechanism is fixedly connected to the front cover of the ceramic blood distribution valve. The five-channel micro-quantification blood distribution valve is fixedly connected to the front cover of the ceramic blood distribution valve, the ceramic shunt plate, and the rear cover of the ceramic blood distribution valve, and penetrates through the front cover of the ceramic blood distribution valve, the ceramic shunt plate, and the rear cover of the ceramic blood distribution valve. Among them, the five-channel micro-quantification blood distribution valve includes 5 different channels, which are arranged in a circular array form, increasing the types of detections and shortening the detection time.
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Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a multi-channel micro-quantification system for a blood cell analyzer. Background Art

[0002] The main components in human blood include white blood cells, red blood cells, platelets, etc. Among them, white blood cells are further divided into five types: lymphocytes, monocytes, basophils, neutrophils, and eosinophils. In hospitals, routine blood tests are used to count the cells in the blood, providing information support for the next step of medical treatment. This is the conventional and most common five-category classification. Therefore, medical units have an increasingly urgent need for the automation, speed, and detection items of blood testing equipment, and need to complete the detection and obtain results in a short time. This requires performing detections on several detection channels at the same time. Therefore, it is necessary to aspirate multiple segments of blood and distribute them to different channels according to different volumes for detection. Most of the existing five-category instruments aspirate samples according to the WBC, RBC, and WOC channels and then distribute them to the corresponding channels. The types are relatively few and single, and the corresponding detection time is also increased. Summary of the Invention

[0003] The purpose of the present invention is to provide a multi-channel micro-quantification system for a blood cell analyzer, which can increase the detection types and shorten the detection time.

[0004] To achieve the above object, the present invention provides a multi-channel micro-quantification system for a blood cell analyzer. The multi-channel micro-quantification system for a blood cell analyzer includes a ceramic blood distribution valve front cover, a ceramic shunt plate, a ceramic blood distribution valve rear cover, a rotary valve plate mechanism, and a five-channel micro-quantification blood distribution valve. The ceramic blood distribution valve front cover is rotatably connected to the ceramic shunt plate and is located on one side of the ceramic shunt plate. The ceramic blood distribution valve rear cover is rotatably connected to the ceramic shunt plate and is located on the side away from the ceramic blood distribution valve front cover. The rotary valve plate mechanism is fixedly connected to the ceramic blood distribution valve front cover and is located on the side away from the ceramic shunt plate. The five-channel micro-quantification blood distribution valve is fixedly connected to the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover and penetrates through the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover.

[0005] Among them, the five-channel micro-quantification blood distribution valve includes a WBC channel, an RBC channel, a WOC channel, a RET channel, and an NRBC channel. The WBC channel, the RBC channel, the WOC channel, the RET channel, and the NRBC channel are all fixedly connected to the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover and penetrate through the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover, and are arranged in a circular array form.

[0006] Among them, the WBC channel, the RBC channel, the WOC channel, the RET channel, and the NRBC channel all have inlets and outlets. The inlets of the WBC channel, the RBC channel, and the NRBC channel, and the outlets of the WBC channel, the RET channel, and the NRBC channel all penetrate through the front cover of the ceramic blood distribution valve; the inlets of the WOC channel and the RET channel, and the outlets of the WOC channel and the RBC channel all penetrate through the rear cover of the ceramic blood distribution valve.

[0007] Among them, the multi-channel micro-quantification system of the hematology analyzer further includes a sample channel, which is fixedly connected to the front cover of the ceramic blood distribution valve and penetrates through the front cover of the ceramic blood distribution valve.

[0008] Among them, the multi-channel micro-quantification system of the hematology analyzer further includes a sampling quantitative sensor, which is fixedly connected to the sample channel and is located on the side far from the front cover of the ceramic blood distribution valve.

[0009] Among them, the multi-channel micro-quantification system of the hematology analyzer further includes a liquid path sensor, which is fixedly connected to the sample channel and is located on one side of the inlet and the outlet of the sample channel.

[0010] Among them, the multi-channel micro-quantification system of the hematology analyzer further includes a limit block, which is fixedly connected to the ceramic shunt plate, is rotationally connected to the front cover and the rear cover of the ceramic blood distribution valve, and is located on one side of the front cover of the ceramic blood distribution valve, the ceramic shunt plate, and the rear cover of the ceramic blood distribution valve.

[0011] Among them, the front cover and the rear cover of the ceramic blood distribution valve have chamfers, and the chamfers are located at the connection between the front cover and the rear cover of the ceramic blood distribution valve and the ceramic shunt plate.

[0012] A multi-channel micro-quantification system for a blood cell analyzer according to the present invention, the multi-channel micro-quantification system for a blood cell analyzer includes a ceramic blood distribution valve front cover, a ceramic shunt piece, a ceramic blood distribution valve rear cover, a rotary valve piece mechanism, and a five-channel micro-quantification blood distribution valve. The ceramic blood distribution valve front cover is rotatably connected to the ceramic shunt piece and is located on one side of the ceramic shunt piece. The ceramic blood distribution valve rear cover is rotatably connected to the ceramic shunt piece and is located on the side away from the ceramic blood distribution valve front cover. The rotary valve piece mechanism is fixedly connected to the ceramic blood distribution valve front cover and is located on the side away from the ceramic shunt piece. The five-channel micro-quantification blood distribution valve is fixedly connected to the ceramic blood distribution valve front cover, the ceramic shunt piece, and the ceramic blood distribution valve rear cover, and penetrates through the ceramic blood distribution valve front cover, the ceramic shunt piece, and the ceramic blood distribution valve rear cover. Among them, the five-channel micro-quantification blood distribution valve includes 5 different channels, which are arranged in a circular array form, increasing the detection types and shortening the detection time. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0014] Figure 1 is a schematic structural diagram of a multi-channel micro-quantification system for a blood cell analyzer provided by the present invention without rotation.

[0015] Figure 2 is provided by the present invention Figure 1 schematic structural diagram after rotation.

[0016] Figure 3 is a schematic structural diagram of the ceramic blood distribution valve front cover provided by the present invention.

[0017] Figure 4 is a schematic structural diagram of the ceramic blood distribution valve rear cover provided by the present invention.

[0018] Figure 5 is a schematic structural diagram of the chamfer of the blood distribution valve provided by the present invention.

[0019] 1 - Front cover of ceramic blood distribution valve, 2 - Ceramic shunt piece, 3 - Rear cover of ceramic blood distribution valve, 4 - Rotary valve plate mechanism, 5 - Five-channel micro quantitative blood distribution valve, 51 - WBC channel, 52 - RBC channel, 53 - WOC channel, 54 - RET channel, 55 - NRBC channel, 511 - WBC channel inlet, 512 - WBC channel outlet, 521 - RBC channel inlet, 522 - RBC channel outlet, 531 - WOC channel inlet, 532 - WOC channel outlet, 541 - RET channel inlet, 542 - RET channel outlet, 551 - NRBC channel inlet, 552 - NRBC channel outlet, 6 - Sample channel, 61 - Sample channel inlet, 62 - Sample channel outlet, 7 - Sampling quantitative sensor, 8 - Liquid path sensor, 9 - Limit block, 10 - Chamfer. Detailed implementation manners

[0020] The embodiments of the present invention will be described in detail below. Examples of the embodiments are shown in the drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the drawings are exemplary and are intended to explain the present invention and should not be construed as limiting the present invention.

[0021] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as limiting the present invention. In addition, in the description of the present invention, the meaning of "a plurality of" is two or more unless otherwise specifically defined.

[0022] Please refer to Figure 1 and Figure 2, the present invention provides a multi-channel micro-quantification system for a hematology analyzer. The multi-channel micro-quantification system for a hematology analyzer includes a ceramic blood distribution valve front cover 1, a ceramic shunt plate 2, a ceramic blood distribution valve rear cover 3, a rotary valve plate mechanism 4, and a five-channel micro-quantification blood distribution valve 5. The ceramic blood distribution valve front cover 1 is rotatably connected to the ceramic shunt plate 2 and is located on one side of the ceramic shunt plate 2. The ceramic blood distribution valve rear cover 3 is rotatably connected to the ceramic shunt plate 2 and is located on the side away from the ceramic blood distribution valve front cover 1. The rotary valve plate mechanism 4 is fixedly connected to the ceramic blood distribution valve front cover 1 and is located on the side away from the ceramic shunt plate 2. The five-channel micro-quantification blood distribution valve 5 is fixedly connected to the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3 and penetrates through the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3.

[0023] In this embodiment, the multi-channel micro-quantification system of the hematology analyzer includes a ceramic blood distribution valve front cover 1, a ceramic shunt plate 2, a ceramic blood distribution valve rear cover 3, a rotary valve plate mechanism 4, and a five-channel micro-quantification blood distribution valve 5. The ceramic blood distribution valve front cover 1 is rotatably connected to the ceramic shunt plate 2 and is located on one side of the ceramic shunt plate 2. The ceramic blood distribution valve rear cover 3 is rotatably connected to the ceramic shunt plate 2 and is located on the side away from the ceramic blood distribution valve front cover 1. The rotary valve plate mechanism 4 is fixedly connected to the ceramic blood distribution valve front cover 1 and is located on the side away from the ceramic shunt plate 2. The five-channel micro-quantification blood distribution valve 5 is fixedly connected to the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3 and penetrates through the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3. Among them, the five-channel micro-quantification blood distribution valve 5 is composed of 5 channels. The blood distribution valve composed of the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3 performs precise quantitative separation of the whole blood sample through relative selective movement, and the separated blood samples are separated into different individual reaction pools to complete the detection. At the beginning, the whole micro-quantification system is sampled by a micro-syringe, and then the ceramic blood distribution valve front cover 1 and the ceramic blood distribution valve rear cover 3 are rotated and switched by the motor system. The rotary valve plate mechanism 4 drives the ceramic blood distribution valve front cover 1 to rotate counterclockwise and the ceramic blood distribution valve rear cover 3 to rotate clockwise respectively. The middle ceramic shunt plate 2 remains stationary. The notches above the ceramic blood distribution valve front cover 1 and the ceramic blood distribution valve rear cover 3 rotate to specific positions, and the sample that was previously connected as one channel is cut into five independent channels, and the blood quantification of the five channels can be completed instantly. The sample stored in the shunt block and the sample in the three bent steel pipes are mixed with a certain amount of diluent injected from the corresponding pipe orifice to form a mixed solution, which is respectively pressurized and circulated to the corresponding reaction cups for reaction counting. After the sample distribution is completed, the rotary valve plate mechanism 4 drives the ceramic blood distribution valve front cover 1 to rotate clockwise and the ceramic blood distribution valve rear cover 3 to rotate counterclockwise, and the ceramic shunt plate 2 still remains stationary until the initial set position, which is consistent with the initial sampling state. At this time, there is some residual sample and mixed solution in the channel, and it is necessary to backflush the reagent from the sample outlet end of the blood distribution valve to the sample inlet end of the blood distribution valve to clean the whole channel, reduce cross-contamination, and prepare for the next sample distribution. The three channels are changed to five channels, and optimization is carried out in micro-quantification, which shortens the counting time for fast automatic counting and increases the types of detections, saving time and economic costs for the medical institutions using it.

[0024] Further, the five-channel micro quantitative blood distribution valve 5 includes a WBC channel 51, an RBC channel 52, a WOC channel 53, a RET channel 54, and an NRBC channel 55. The WBC channel 51, the RBC channel 52, the WOC channel 53, the RET channel 54, and the NRBC channel 55 are all fixedly connected to the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3, and penetrate through the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3, and are arranged in a circular array form.

[0025] In this embodiment, the five-channel micro quantitative blood distribution valve 5 includes a WBC channel 51, an RBC channel 52, a WOC channel 53, a RET channel 54, and an NRBC channel 55. The WBC channel 51, the RBC channel 52, the WOC channel 53, the RET channel 54, and the NRBC channel 55 are all fixedly connected to the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3, and penetrate through the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3, and are arranged in a circular array form. On the basis of the three channels of its conventional WBC channel 51, RBC channel 52, and WOC channel 53, the RET channel 54 and the NRBC channel 55 are added. Since there are large diameter changes in these two channels, and the NRBC storage sample error requirement is about ±0.5 ul, in order to reduce air bubbles during sample injection, fill the sample storage, and ensure that there is no residue in the sample cleaning channel 6, chamfers 10 need to be made at the corresponding hole positions of the front cover and rear cover of the blood distribution valve to allow the flowing liquid to be sufficient and cleaned. Among them, RET is reticulocyte, which is an important evaluation index for the treatment effect and treatment test of anemia clinically. NRBC is nucleated red blood cell, which is one of the important indexes for the determination of hyperplastic anemia, erythroleukemia, pernicious anemia, and cancer tumors. Among them, the RBC channel 52, the WOC channel 53, and the NRBC channel 55 are bent steel pipes. The volumes of the three steel pipes are accurately quantitatively calculated to store the required samples of HGB, NRBC, and WOC. The three channels are changed to five channels, and optimization processing is carried out in micro quantitative to shorten the counting time for rapid automatic counting, saving time and economic costs for the medical units and institutions using it.

[0026] Further, the WBC channel 51, the RBC channel 52, the WOC channel 53, the RET channel 54, and the NRBC channel 55 all have inlets and outlets. The inlets of the WBC channel 51, the RBC channel 52, and the NRBC channel, and the outlets 552 of the WBC channel 51, the RET channel 54, and the NRBC channel all penetrate through the front cover 1 of the ceramic blood distribution valve; the inlets 541 of the WOC channel 53 and the RET channel, and the outlets 522 of the WOC channel 53 and the RBC channel all penetrate through the rear cover 3 of the ceramic blood distribution valve.

[0027] In this embodiment, the WBC channel 51, the RBC channel 52, the WOC channel 53, the RET channel 54, and the NRBC channel 55 all have inlets and outlets. The inlet 511 of the WBC channel, the inlet 521 of the RBC channel, and the inlet 551 of the NRBC channel, the outlet 512 of the WBC channel, the outlet 542 of the RET channel, and the outlet 552 of the NRBC channel all penetrate through the front cover 1 of the ceramic blood distribution valve; the inlet 531 of the WOC channel and the inlet 541 of the RET channel, the outlet 532 of the WOC channel and the outlet 522 of the RBC channel all penetrate through the rear cover 3 of the ceramic blood distribution valve, and its structure is as Figure 3 and 4 shown. The entire blood distribution valve is connected to the three bent steel pipes from the steel pipe inlet to the steel pipe outlet to form an integral body, including the blood distribution valve shunt plate through which the sample passes. At this time, the inner hole of the shunt plate is also filled with the sample. The quantitative sizes of the RBC and RET samples are determined by the volume of the inner hole of the shunt plate. Here is a key arrangement of the hole positions: The hole positions of the front cover 1 of the ceramic blood distribution valve, the ceramic shunt plate 2, and the rear cover 3 of the ceramic blood distribution valve are not allowed to cross during the rotation process because there may be problems such as sample contamination, dilution, and inaccurate quantification during the crossing of the hole positions. Therefore, during the rotation process, the hole positions between the sample channels 6 cannot cross each other and should be separated and isolated from each other to ensure that the sample quantification is consistent for each sampling. Therefore, the hole positions of the NRBC and WOC are separated vertically and horizontally to ensure that the hole positions are separated and do not cross each other in the same space size without changing the rotational angular velocity. The edge distance between the upper and lower hole positions should be greater than 1 mm. If it is too small, there is also an easy leakage phenomenon of the hole positions, and it also reduces the processing accuracy and difficulty of the parallel plane.

[0028] Further, the multi-channel micro-quantification system of the hematology analyzer further includes a sample channel 6. The sample channel 6 is fixedly connected to the front cover 1 of the ceramic blood distribution valve and penetrates through the front cover 1 of the ceramic blood distribution valve.

[0029] In this embodiment, the multi-channel micro-quantification system of the hematology analyzer further includes a sample channel 6. The sample channel 6 is fixedly connected to the front cover 1 of the ceramic blood distribution valve and penetrates through the front cover 1 of the ceramic blood distribution valve. Its structure is as Figure 3 shown. The test sample enters the blood distribution valve through the sample channel inlet 61. After the test is completed, since there is some residual sample and mixed liquid in the channel, it is necessary to backflush the reagent from the sample channel outlet 62 of the blood distribution valve to the sample injection end of the blood distribution valve to clean the entire channel.

[0030] Furthermore, the multi-channel micro-quantification system of the hematology analyzer further includes a sampling quantitative sensor 7. The sampling quantitative sensor 7 is fixedly connected to the sample channel 6 and is located on the side away from the front cover 1 of the ceramic blood distribution valve.

[0031] In this embodiment, the multi-channel micro-quantification system of the hematology analyzer further includes a sampling quantitative sensor 7. The sampling quantitative sensor 7 is fixedly connected to the sample channel 6 and is located on the side away from the front cover 1 of the ceramic blood distribution valve. The sampling quantitative sensor 7 is used to monitor the inhalation volume of the test sample in real time, collect the curve of blood flow, and analyze to obtain the blood-sucking full state for subsequent analysis.

[0032] Furthermore, the multi-channel micro-quantification system of the hematology analyzer further includes a liquid path sensor 8. The liquid path sensor 8 is fixedly connected to the sample channel 6 and is located on one side of the sample channel inlet 61 and the sample channel outlet 62.

[0033] In this embodiment, the multi-channel micro-quantification system of the hematology analyzer further includes a liquid path sensor 8. The liquid path sensor 8 is fixedly connected to the sample channel 6 and is located on one side of the sample channel inlet 61 and the sample channel outlet 62. The liquid path sensor 8 is used to detect whether the sample completely fills the cavity of the blood distribution valve. Therefore, it is required that the liquid path sensors 8 at the sample channel inlet 61 and the sample channel outlet 62 both detect the presence of the sample at the same time. At this time, the steel pipe connecting the inlet to the outlet of the entire blood distribution valve is filled with the sample.

[0034] Furthermore, the multi-channel micro-quantification system of the hematology analyzer further includes a limit block 9. The limit block 9 is fixedly connected to the ceramic shunt piece 2, is rotatably connected to the front cover 1 of the ceramic blood distribution valve and the rear cover 3 of the ceramic blood distribution valve, and is located on one side of the front cover 1 of the ceramic blood distribution valve, the ceramic shunt piece 2, and the rear cover 3 of the ceramic blood distribution valve.

[0035] In this embodiment, the multi-channel micro-quantification system of the hematology analyzer further includes a limit block 9. The limit block 9 is fixedly connected to the ceramic shunt plate 2, and is rotatably connected to the front cover 1 of the ceramic blood distribution valve and the rear cover 3 of the ceramic blood distribution valve, and is located on one side of the front cover 1 of the ceramic blood distribution valve, the ceramic shunt plate 2, and the rear cover 3 of the ceramic blood distribution valve. When the sample enters the blood distribution valve cavity for blood distribution, the rotary valve plate mechanism 4 drives the front cover 1 of the ceramic blood distribution valve to rotate counterclockwise and the rear cover 3 of the ceramic blood distribution valve to rotate clockwise respectively, and the middle ceramic shunt plate 2 remains stationary. The notches above the front cover 1 of the ceramic blood distribution valve and the rear cover 3 of the ceramic blood distribution valve rotate to the position of the limit block 9. As Figure 2 shown, the sample that was previously connected into one channel is cut into five independent channels. When the loading and circulation are completed, the blood distribution valve switches back to the initial state. The rotary valve plate mechanism 4 drives the front cover 1 of the ceramic blood distribution valve to rotate clockwise and the rear cover 3 of the ceramic blood distribution valve to rotate counterclockwise, and the ceramic shunt plate 2 still remains stationary and stops at the position of the limit block 9, which is consistent with the initial sample aspiration state.

[0036] Furthermore, the front cover 1 of the ceramic blood distribution valve and the rear cover 3 of the ceramic blood distribution valve have chamfers 10, and the chamfers 10 are located at the connection between the front cover 1 of the ceramic blood distribution valve and the rear cover 3 of the ceramic blood distribution valve and the ceramic shunt plate 2.

[0037] In this embodiment, during the sample aspiration and cleaning processes, due to the need for quantification, one of the apertures of the ceramic shunt plate 2 of the blood distribution valve is larger than the through-hole apertures of the front and rear covers. This is equivalent to the sample first passing from a small aperture to a large aperture and then exiting through a small aperture. In this way, a problem exists that voids are generated at the four corners of the large aperture, which is likely to form eddy currents and is not conducive to filling the sample completely and backwashing and cleaning. Therefore, reasonable chamfering 10 treatment is performed at the through-holes of the front cover 1 of the ceramic blood distribution valve and the rear cover 3 of the ceramic blood distribution valve, and its structure is as Figure 5 shown. Considering the factor of rotational error, the outer diameter of the chamfers 10 of the front and rear covers is slightly larger than the aperture of the through-hole of the shunt plate. Such a design is conducive to filling the aperture of the shunt block with the sample, reducing the formation of eddy currents, and is also conducive to more thorough backwashing and cleaning, and reduces the process variation and complexity.

[0038] A multi-channel micro-quantification system for a blood cell analyzer according to the present invention, the multi-channel micro-quantification system for a blood cell analyzer includes a ceramic blood distribution valve front cover 1, a ceramic shunt plate 2, a ceramic blood distribution valve rear cover 3, a rotary valve plate mechanism 4, and a five-channel micro-quantification blood distribution valve 5. The ceramic blood distribution valve front cover 1 is rotatably connected to the ceramic shunt plate 2 and is located on one side of the ceramic shunt plate 2. The ceramic blood distribution valve rear cover 3 is rotatably connected to the ceramic shunt plate 2 and is located on the side away from the ceramic blood distribution valve front cover 1. The rotary valve plate mechanism 4 is fixedly connected to the ceramic blood distribution valve front cover 1 and is located on the side away from the ceramic shunt plate 2. The five-channel micro-quantification blood distribution valve 5 is fixedly connected to the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3 and penetrates through the ceramic blood distribution valve front cover 1, the ceramic shunt plate 2, and the ceramic blood distribution valve rear cover 3. Among them, the five-channel micro-quantification blood distribution valve 5 includes 5 different channels arranged in a circular array form. A micro syringe is used to obtain a test sample, and multi-channel blood distribution and counting are performed. After the counting is completed, the channels are cleaned with a flushing reagent, increasing the types of detections and shortening the detection time.

[0039] The above-disclosed is only a preferred embodiment of the present invention. Of course, it cannot be used to limit the scope of the rights of the present invention. Those of ordinary skill in the art can understand all or part of the processes of implementing the above embodiments, and the equivalent changes made according to the claims of the present invention still fall within the scope covered by the invention.

Claims

1. A multi-channel micro-quantification system for a blood cell analyzer, characterized in that, The multi-channel micro-quantification system of the hematology analyzer includes a ceramic blood distribution valve front cover, a ceramic shunt plate, a ceramic blood distribution valve rear cover, a rotary valve plate mechanism, and a five-channel micro-quantification blood distribution valve. The ceramic blood distribution valve front cover is rotatably connected to the ceramic shunt plate and is located on one side of the ceramic shunt plate. The ceramic blood distribution valve rear cover is rotatably connected to the ceramic shunt plate and is located on the side away from the ceramic blood distribution valve front cover. The rotary valve plate mechanism is fixedly connected to the ceramic blood distribution valve front cover and is located on the side away from the ceramic shunt plate. The five-channel micro-quantification blood distribution valve is fixedly connected to the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover, and penetrates through the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover; The five-channel micro-quantification blood distribution valve 5 is composed of 5 channels. The blood distribution valve composed of the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover performs precise quantitative separation of the whole blood sample through relative selective movement, and the separated blood samples are separated into different individual reaction pools by using the rotary valve plate mechanism; The five-channel micro-quantification blood distribution valve includes a WBC channel, an RBC channel, a WOC channel, a RET channel, and an NRBC channel. The WBC channel, the RBC channel, the WOC channel, the RET channel, and the NRBC channel are all fixedly connected to the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover, and penetrate through the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover, and are arranged in a circular array; The WBC channel, the RBC channel, the WOC channel, the RET channel, and the NRBC channel all have inlets and outlets. The inlets of the WBC channel, the RBC channel, and the NRBC channel, and the outlets of the WBC channel, the RET channel, and the NRBC channel all penetrate through the ceramic blood distribution valve front cover; The inlets of the WOC channel and the RET channel, and the outlets of the WOC channel and the RBC channel all penetrate through the ceramic blood distribution valve rear cover.

2. The multi-channel micro-quantification system for a blood cell analyzer according to claim 1, wherein The multi-channel micro-quantification system of the hematology analyzer further includes a sample channel, which is fixedly connected to the ceramic blood distribution valve front cover and penetrates through the ceramic blood distribution valve front cover.

3. The multi-channel micro-quantification system for a blood cell analyzer according to claim 2, characterized in that The multi-channel micro-quantification system of the hematology analyzer further includes a sampling quantitative sensor, which is fixedly connected to the sample channel and is located on the side away from the ceramic blood distribution valve front cover.

4. The multi-channel micro-quantification system of a blood cell analyzer according to claim 2, characterized in that, The multi-channel micro-quantification system of the hematology analyzer further includes a liquid path sensor, which is fixedly connected to the sample channel and is located on one side of the sample channel inlet and the sample channel outlet.

5. The multi-channel micro-quantification system of a blood cell analyzer according to claim 1, characterized in that, The multi-channel micro-quantification system of the hematology analyzer further includes a limit block, which is fixedly connected to the ceramic shunt plate, is rotatably connected to the ceramic blood distribution valve front cover and the ceramic blood distribution valve rear cover, and is located on one side of the ceramic blood distribution valve front cover, the ceramic shunt plate, and the ceramic blood distribution valve rear cover.

6. The multi-channel micro-quantification system for a blood cell analyzer according to claim 1, wherein, The front cover and the rear cover of the ceramic blood distribution valve have chamfers, and the chamfers are located at the connection between the front cover and the rear cover of the ceramic blood distribution valve and the ceramic shunt plate.

Citation Information

Patent Citations

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