45 results about "Blood cell analysis" patented technology

A blood cell analyzer (100) and a blood cell analysis method (300). The blood cell analysis method (300) comprises: sucking a blood sample to be tested; preparing a first determination sample and obtaining first optical information; preparing a second determination sample and obtaining second optical information; generating a first leukocyte classification scatter diagram and a second leukocyte classification scatter diagram; determining a first counting result of neutrophils of the to-be-detected blood sample based on the first leukocyte classification scatter diagram and the second leukocyte classification scatter diagram; determining an actual distribution area of neutrophils from the first leukocyte classification scatter diagram; based on a reference distribution region of neutrophils of a reference leukocyte classification scatter diagram of the normal blood sample, determining a leaf-division nucleophore distribution region from the actual distribution region; determining a second counting result of the cells falling into the leaf-separating nucleogranulocyte distribution area; and based on the first counting result and the second counting result, determining a counting result of the rod-shaped nuclear granulocytes in the to-be-detected blood sample.

The invention discloses a hematology analyzer and a platelet numerical value measuring method, in the hematology analyzer, an analysis unit is used for receiving a pulse signal to generate a first image, receiving an optical signal to generate a second image, obtaining a platelet original numerical value based on the first image, obtaining an interference coefficient of a leukocyte fragment based on the second image, and obtaining the platelet numerical value based on the interference coefficient; and obtaining a platelet measurement value based on the platelet original value and the interference coefficient. Through the cooperation of the impedance module and the flow fluorescence module, the platelet original value in the blood cell sample and the interference coefficient of the leukocyte fragment are detected, and the accuracy of each step in the calculation process of the platelet measurement value is ensured. Meanwhile, the platelet measurement numerical value is calculated through the analysis unit based on the platelet original numerical value and the interference coefficient, so that the accuracy of the blood cell analyzer for measuring the platelet measurement numerical value is improved, the practicability of the blood cell analyzer is improved, and the use experience of a user on the blood cell analyzer is improved.

The invention discloses a hematology analyzer and a detection method for hole blockage of a flow chamber, in the hematology analyzer provided by the invention, in the process that sample liquid enters the flow chamber for sample detection, a control unit can also obtain signal parameters based on optical signals of the sample liquid flowing through the flow chamber; whether the flow chamber is blocked or not is judged, the safety of the flow chamber is improved, and the detection efficiency of an optical detection system on sample liquid is improved. Meanwhile, in the process of detecting the sample liquid, whether the flow chamber has the hole blocking problem or not can be judged, the step of judging the hole blocking of the flow chamber does not need to be additionally set, the operation efficiency of the hematology analyzer is improved, and the use experience of a user on the hematology analyzer is improved.

The present disclosure relates to a method for white blood cell differential counting using whole blood in a fluid state, and the like. The method of the present disclosure does not include the drying and washing processes used in traditional blood cell analysis to provide a standard for multiple white blood cell analysis, thereby enabling rapid analysis with high repeatability and reproducibility even when large quantities of samples are being processed, and providing accurate test results including the numbers, ratios, and morphological discrimination for each type of white blood cells.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, the first bearing position is arranged on the sample injection module to bear the detection card for receiving the first to-be-detected sample, and the second bearing position is arranged on the first detection module to bear the detection card after receiving the first to-be-detected sample, so that the receiving and detection of the first to-be-detected sample are separately carried out at different bearing positions of different modules; the transfer module is arranged at the output end of the driving module of the preprocessing module, so that the driving module can drive the transfer module to transfer the detection card from the first bearing position to the second bearing position after driving the pipetting consumable through the loading module to transfer the first to-be-detected sample into the detection card at the first bearing position; therefore, the driving module is ingeniously used for driving the transfer module, and a driving device special for driving the transfer module is avoided, so that the overall structure of the analyzer is simpler, the production cost is reduced, and the analyzer is more compact and miniaturized in structure.

This application provides a method for using a POCT hematology analyzer, comprising: in response to a reagent kit being placed in a test chamber, controlling a pipette to move above the first mounting head reservoir of the reagent kit and descending to load the first mounting head; controlling the pipette to move to the diluent reservoir of the reagent kit to transfer the diluent into the pre-cell for impedance detection; controlling the pipette to transfer a sample into the pre-cell; mixing the test solution in the pre-cell; controlling the metal shielding cap to close with the test chamber to establish a connection between the rear cell and the pressure building system of the reagent kit; controlling the pressure building system to guide the test solution from the pre-cell into the rear cell; and detecting the test solution by impedance detection.

To reduce a work load by shortening a moving distance of an operator.SOLUTION: A composite analysis system 1 includes: a blood cell analyzer 2; a blood coagulation measurement device 3; and a transport device 4 having a transport path 50. The blood cell analyzer 2, the blood coagulation measurement device 3, and the transport device 4 are arranged at a position and orientation that allow at least one of access to a power supply operation reception unit of the blood cell analyzer 2 and the blood coagulation measurement device 3 from one side along the transport path 50, access to a consumable item setting unit of the respective devices from one side along the transport path 50, access to a terminal device of the respective devices from one side along the transport path 50, and access to a maintenance management target unit of the respective devices from one side along the transport path 50.SELECTED DRAWING: Figure 1

The application discloses a blood cell analyzer and a blood cell analysis method. The liquid storage assembly of the blood cell analyzer comprises a liquid storage cavity. The height of the inlet of the liquid storage cavity is less than the height of the outlet. The first end of the temporary storage mechanism of the liquid path emptying assembly is connected with the pressure supply mechanism. The second end of the temporary storage mechanism is connected with the inlet of the liquid storage assembly through the first control valve. The processor is used to control the pressure supply mechanism to switch the temporary storage mechanism to the negative pressure state in response to receiving the liquid draining instruction. The processor is also used to control the first control valve to conduct the liquid storage assembly and the temporary storage mechanism, so that the liquid in the liquid storage cavity is drained through the pipeline between the first control valve and the liquid storage assembly. The liquid in the liquid storage cavity can be drained through the pipeline between the first control valve and the liquid storage assembly by the temporary storage mechanism in the negative pressure state, the residual reagent in the liquid storage cavity is removed, the blockage failure caused by the evaporation and crystallization of the reagent is reduced or avoided, and the service life and reliability of the blood cell analyzer are improved.

The utility model discloses a built-in hemolytic agent bottle and hematology analyzer relates to medical instrument technical field, wherein the built-in hemolytic agent bottle includes solvent bottle, movable joint block and pipeline subassembly, solvent bottle includes mutually communicated bottle body and bottle cap, bottle body and bottle cap detachable connection, bottle cap far away from bottle body side is equipped with the movable mouth; the movable connector block is movably arranged at the movable opening, the movable connector block and the movable opening are arranged in a clearance mode, and the movable connector block is provided with a mounting hole which is formed in the thickness direction in a penetrating mode; the pipeline assembly is fixedly arranged at the mounting hole, one end of the pipeline assembly extends into the bottle body, and the other end of the pipeline assembly penetrates out of the mounting hole and is communicated with an external liquid system. According to the technical scheme, the problem that when a bottle cap of an existing built-in hemolytic agent bottle is screwed down, a pipeline is prone to being bent is solved.

The invention belongs to the technical field of biomedical detection, and discloses a blood cell analysis system based on image flow cytometry, which comprises a cell staining module, the dyeing module simultaneously comprises a first fluorescent probe capable of being specifically combined with components in a cell nucleus or enriched in the cell nucleus, a second fluorescent probe capable of being specifically combined with cell nucleus DNA and a third fluorescent probe capable of being specifically combined with a blood cell differentiation antigen; an image flow cytometer; and the image processing module is used for calculating the kernel detection rate and / or the average kernel number. According to the present invention, the combination of the specific types of the cell staining dyes is adopted, the image flow cytometry is matched, and the optimized multi-dimensional fluorescence staining combination and the matched automatic image analysis process are adopted to achieve the synchronous, high-throughput and accurate quantitative analysis of the blood cell immune phenotype and the cell morphology key characteristics at the single cell level;

This application relates to a sample analysis system and a method for detecting platelet abnormalities. The sample analysis system includes: a blood cell analysis device, comprising a sample preparation unit and a detection unit, wherein the sample preparation unit is configured to prepare a test sample from a blood sample to be tested, and the detection unit is configured to test the test sample to obtain a first platelet detection result; a smear preparation device, configured to prepare a smear of the test sample from the blood sample to be tested; a cell image capturing device, configured to capture cell images of the test sample smear to obtain cell images of the blood sample to be tested, and to analyze the cell images to obtain a second platelet detection result; and a data processing device, configured to determine whether platelet abnormalities exist in the blood sample to be tested based on the first and second platelet detection results, and to output a platelet abnormality prompt when a platelet abnormality is determined to exist. This enables more accurate identification of platelet abnormalities.

The invention relates to a blood cell analyzer and a blood cell analysis method. Sucking a to-be-detected blood sample; mixing a part of the blood sample to be detected, a hemolytic agent and a first fluorescent staining agent to prepare a first measurement sample, and detecting first optical information of particles in the first measurement sample; mixing the other part of the blood sample to be measured, the diluent and a second fluorescent staining agent to prepare a second measurement sample, and detecting second optical information of particles in the second measurement sample; acquiring first leukocyte classification information based on the first optical information; when it is judged that classification abnormity exists in the first leukocyte classification scatter diagram, second leukocyte classification information is obtained based on the second optical information, and the second leukocyte classification information is used for correcting the first leukocyte classification information. According to the invention, an accurate leukocyte classification result can be obtained.

The present application relates to the technical field of biological cell collection and preservation, in particular to a peripheral blood immune cell efficient collection and low-temperature storage method, comprising: collecting peripheral blood samples and obtaining donor health status information, generating a sample cell composition atlas containing lymphocyte subpopulation absolute count percentage, monocyte purity and granulocyte contamination ratio through full-automatic blood cell analysis, determining the target immune cell optimal collection amount and adaptive collection process through a preset data analysis model, enriching target cells through gradient density centrifugation and specific magnetic bead sorting, comparing and judging supplementary collection by combining cell quality inspection data and expected collection amount, and then calculating individualized cryopreservation liquid formula, cooling program and storage strategy through a low-temperature storage optimization algorithm. The method can realize precise individualized adaptation of the collection process and storage parameters, and improve the cell enrichment purity and the cell state stability after low-temperature storage.

The invention relates to the technical field of blood analysis, in particular to a scatter diagram-based lipid particle identification method and a blood cell analyzer. The method comprises the following steps: extracting lipid particle characteristics in a three-dimensional scatter diagram of a blood sample to obtain sample curve characteristics and particle number characteristics, and obtaining a lipid particle identification result of the three-dimensional scatter diagram based on the sample curve characteristics and the particle number characteristics; and outputting alarm information under the condition that the lipid particle recognition result represents that the lipid particles exist in the three-dimensional scatter diagram. By adopting the method, the cell counting accuracy can be improved.

The invention provides a platelet simulant as well as a preparation method and application thereof, the preparation method comprises the following steps: acquiring platelets from whole blood of mammals, fixing the platelets by using a fixing agent, and then storing the platelets in a preservative solution; the fixing agent comprises 0.01-1% (v / v) of formaldehyde, 0.01-1% (v / v) of glutaraldehyde, 0.1-2% (v / v) of a dispersing agent and 0.1-10 g / L of an anti-polymerization agent. According to the preparation method, platelets are obtained from mammal whole blood, raw material sources are easy to obtain, and the cost is low; the preparation method is simple to operate and beneficial to large-scale production of the product; the prepared platelet simulant is stable in performance, small in batch difference and good in simulation performance, and can be simultaneously applied to an electrical impedance channel, an optical channel and a fluorescent channel of a hematology analyzer.

This invention relates to the field of hematology analysis technology, and in particular to a diluent for hematology analysis, its preparation method, and its uses. The diluent comprises the following components: 0.5-15 g / L of inorganic salt, 0.01-5.0 g / L of preservative, and 0.1-0.5 g / L of stabilizing agent; the solvent of the diluent is water; the diluent also includes an anti-precipitant, selected from one or more of salt-based and organic anti-precipitants; the salt-based anti-precipitant includes one or more of thiocyanate and nitrate, with a content of 2.0-5.0 mmol / L; the organic anti-precipitant includes one or more of trehalose, mannitol, and amino acid ionic liquids, with a content of 4.0-8.0 mmol / L. In this diluent, the components work synergistically to reduce the maintenance cost of the hematology analyzer, increase its service life, and improve detection efficiency.

This utility model provides a reagent bottle assembly and a blood cell analyzer incorporating the same. The reagent bottle assembly, used in the blood cell analyzer, includes: a reagent bottle body; a flexible tube with an input end and an output end, the input end being located inside the reagent bottle body and the output end being located outside the reagent bottle body; and a suction head located inside the reagent bottle body and positioned at the input end. A first end of the suction head is connected to the input end, and a second end of the suction head has an opening. The suction head has a suction channel connecting the input end and the opening. The center of gravity of the suction head is located on the side of a preset plane away from the input end, wherein the preset plane is half-height plane of the suction head. The technical solution of this application effectively solves the problem of poor suction effect in related technologies.

The invention relates to a monocyte simulation composition, a preparation method, a quality control substance and a quality control method. The mononuclear cell simulation composition comprises mononuclear cell simulation particles stored in a preservation solution, the volume ratio of the mononuclear cell simulation particles in the composition is 50% or above, the mononuclear cell simulation particles are obtained by treating neutrophils or lymphocytes separated from blood of mammals, and the mononuclear cell simulation particles are used for simulating the mononuclear cells or the lymphocytes. When the mononuclear cell simulation particle is tested by a hematology analyzer, the mononuclear cell simulation particle has the same or similar light scattering characteristics as human mononuclear cells, and the light scattering characteristics at least reflect the complexity of cell contents. The mononuclear cell simulation particles are independently prepared, so that the particles have good consistency and stability, and the obtained composition is small in batch-to-batch difference when serving as a quality control substance, so that the quality control of a hematology analyzer is facilitated, and the reliability of clinical examination of the hematology analyzer is improved.

The application discloses a kit and a blood cell analyzer. One end of one electrode of the front cell electrode and the rear cell electrode of the kit extends to one side where the other end of the other electrode is exposed on the same side of the shell through a microporous sheet, so that the kit can be connected with the front cell electrode and the rear cell electrode in one direction when the kit is electrically connected with the blood cell analyzer. The alignment process of the kit and the blood cell analyzer is simple, the alignment accuracy of the blood cell analyzer and the kit is improved, the electrical connection stability of the kit and the blood cell analyzer is improved, the possibility of failure, such as undetectable, caused by inaccurate alignment of the kit and the blood cell analyzer is reduced, and the user experience is improved.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, a first bearing position is arranged on a sample introduction module and used for bearing a detection card, a second bearing position is arranged on a first detection module and used for bearing the detection card, and a first sample to be detected is transferred into the detection card located at the first bearing position through a pretreatment module; and transferring the detection card receiving the first to-be-detected sample at the first bearing position to the second bearing position through a transfer module, and detecting the settled first to-be-detected sample in the detection card at the second bearing position through the microscope unit, therefore, each detection card receives the first to-be-detected sample and the detection of the first to-be-detected sample after settlement is carried out at different bearing positions, so that the detection efficiency of the POCT hematology analyzer can be effectively improved.

The invention relates to the technical field of hematology analyzers, and discloses a cell analyzer sample introduction device which comprises a machine body, a detection cavity, a feeding drawer, a hydraulic cylinder and a sample introduction calibration module, and a bin door is hinged to the front face of the machine body. The stable and controllable driving force is provided through the electric push rod and transmitted to the single rack through the push block, the synchronous gear is matched to synchronously and symmetrically transmit the movement to the rack on the other side, clear guide is provided for placement, stable circumferential constraint is formed after clamping, and the clamping precision is improved. The test tubes are effectively prevented from deviating or shaking in the horizontal direction possibly in the subsequent conveying process, the problem that due to manual placement errors or mechanical conveying gaps, the positions of the test tubes on the horizontal plane are uncertain is solved, and therefore radial dislocation of the test tubes and puncture needles at the final detection station is avoided; the problems that the puncture needle cannot accurately pierce into the preset position of the test tube, sampling fails and even the precise puncture needle is damaged are solved.

The embodiment of the invention relates to the field of hematology analyzers, and discloses a hematology analyzer and a debugging method.The debugging method comprises the steps that first feature values of test standard particles of different sizes on a target hematology analyzer are obtained, and a base line of the target hematology analyzer is calculated; the first characteristic value is an abscissa value which is corresponding to the peak value of the pulse distribution histogram and is used for representing the volume of the test standard particle; calculating a particle amplification degree difference between the target hematology analyzer and the standard hematology analyzer according to the base line and the first characteristic value; and adjusting a pulse distribution histogram generated by the target hematology analyzer according to the difference between the baseline and the particle amplification degree of the target hematology analyzer, so that the measured values of the target hematology analyzer and the standard hematology analyzer for the hematohematocrit or the average hematohematocrit of the same test standard particle are consistent. According to the application, the debugging problem of the hematology analyzer is solved, and the influence of instrument hardware on the pulse measurement value is avoided.

A white blood cell classification reagent, kit, and classification method; and a red blood cell analysis reagent, kit, and analytical method. Both the white blood cell classification reagent and the red blood cell analysis reagent contain a fluorescent dye with the general formula F. This dye can stain the nucleic acids of white blood cells and red blood cells, thus enabling accurate classification and / or counting of white blood cells and red blood cells in blood samples during blood analysis, especially the identification and / or counting of RETs. Furthermore, it simplifies the types of dyes used in blood cell analysis.

The utility model discloses a hematology analyzer which comprises a frame body, a power supply assembly, a control circuit board, a reagent supply assembly, an automatic sample injection assembly and a blood routine examination assembly, a first open cavity, a middle wiring cavity and a second open cavity are sequentially formed in the middle of the frame body; the power supply assembly is arranged on the rear end face of the frame body, the control circuit board is arranged at the top of the frame body, the reagent supply assembly is arranged in the second open cavity and on the front end face of the frame body, the automatic sample injection assembly is arranged on the front end face of the frame body, and the blood routine examination assembly is arranged in the first open cavity; the control circuit board is electrically connected with the power supply assembly, the reagent supply assembly, the automatic sample injection assembly and the blood routine examination assembly; the reagent supply assembly is connected with the blood routine examination assembly. According to the utility model, modularized components are adopted, and the components are reasonably arranged, so that the production and assembly efficiency can be improved, and the maintenance is easy.

The utility model discloses an air pump damping structure and a hematology analyzer, and relates to the technical field of medical detection equipment, the air pump damping structure comprises a mounting plate, a damping plate and an air pump, the mounting plate is used for being mounted on a host of the hematology analyzer; the end part of the damping plate is fixedly arranged on the mounting plate, and a gap is formed between the damping plate and the surface of the mounting plate so as to form a suspension space; the air pump is fixed to the damping plate and located above the suspension space. According to the technical scheme provided by the utility model, the problem that the pump body in the existing hematology analyzer is easy to vibrate is solved.

The invention relates to a blood cell analyzer and a blood cell analysis method. The method comprises the following steps: mixing a part of a sucked blood sample to be detected, a diluent and a fluorescent staining agent in a first reaction tank to prepare a first determination sample, and obtaining first optical information generated after particles in the first determination sample are irradiated by light; mixing the other part of the blood sample to be detected with a hemolytic agent in a second reaction tank to prepare a second determination sample, and obtaining colorimetric optical information of the second determination sample; obtaining a reticulocyte detection result, a platelet detection result, an erythrocyte detection result and a first leukocyte detection result of the to-be-detected blood sample based on the first optical information, wherein the first leukocyte detection result at least comprises a lymphocyte percentage, a mononuclear cell percentage and a granulocyte percentage; and determining the hemoglobin concentration of the to-be-detected blood sample based on the colorimetric method optical information. According to the application, the reagent cost required for obtaining the detection result of the to-be-detected blood sample can be reduced.

The invention discloses blood cell analysis equipment and a blood cell analysis method. The equipment comprises a sample injection module, a sample adding module, a detection module, a processor and a display, the sample introduction module is used for acquiring a blood sample; the sample adding module is connected with the sample introduction module and is used for mixing a reagent with a blood sample to obtain a to-be-detected sample solution; the detection module is connected with the sample adding module and is used for detecting the to-be-detected sample liquid to obtain detection data; the processor is connected with the detection module and is used for receiving the detection data and predicting a prediction score of the detection data; the display is connected with the processor and used for displaying an analysis interface which is at least used for displaying the predicted score. Therefore, the predicted score can be directly displayed on the analysis interface of the display, so that medical staff can intuitively obtain the predicted score of the disease risk predicted according to the detection data, the information interpretation efficiency of a user is improved, and the use experience of the user is improved.

The invention discloses an animal blood cell analyzer and an animal blood cell analysis method.According to the animal blood cell analyzer, a first protein detection result is corrected based on serum detection data obtained through searching in a historical database, tedious sample pretreatment is not needed, and the operation process is simplified; the first protein detection result can be corrected based on historical serum detection data, so that the cost of specific protein detection is reduced, the first protein detection result can accurately reflect the organism state of the animal, the error value of the detection result is reduced, and the detection accuracy is improved. The problem that when an existing animal blood cell analyzer uses whole blood to conduct specific protein detection, serum detection data such as fixed hematocrit is adopted for correction, and consequently detection errors are large is solved, and the detection accuracy can be improved.

The application relates to the technical field of blood cell analyzers, in particular to a biosafety blood cell analyzer, which comprises a sealing assembly used for sealing a punctured end of a blood test tube, the sealing assembly comprises a lead screw, the surface of the lead screw is connected in engagement with a sleeve, the sleeve is slidably connected with the inner wall of a cavity through a strip-shaped rod, the upper end of the sleeve is fixedly installed with an elastic telescopic rod, the upper end of the elastic telescopic rod is fixedly connected with a sealing gasket, a puncture needle is arranged below the sealing gasket and fixedly installed at the upper end of the sleeve. Through the cooperation of various components, the generation of the wall-hanging phenomenon can be prevented during sampling, aerosol can be prevented from being generated during sampling, and the accuracy of the detection result is ensured.

The utility model belongs to the technical field of blood cell analyzer auxiliary equipment, and particularly relates to a blood sample diluting and uniformly mixing device for a blood cell analyzer, which is mainly composed of a mixing container and a stirring mechanism. The stirring mechanism comprises a driver, a stirring piece, a sliding frame and a transmission assembly, the longitudinal sliding of the sliding frame and the stable transmission of the transmission assembly are utilized, the stirring piece can continuously rotate in the vertical movement process, and all-directional stirring is achieved. The device is further provided with a sliding rod, a limiting rod, an elastic piece and other structures, stable sliding of the sliding frame is guaranteed, a user can conveniently adjust the stirring position, and operation is convenient and fast. In addition, the stirring and diluting tank adopts an up-down through structure, and a detachable plugging piece at the lower end is convenient to clean, so that cross contamination is effectively avoided. The device effectively solves many problems of a traditional blood sample diluting and uniformly mixing mode, and the blood sample uniformly mixing effect and the detection accuracy are remarkably improved.