64 results about "Cell analyzer" patented technology

The utility model belongs to the technical field of medical instruments, and particularly relates to a blood extraction device for a hematology analyzer, which comprises an electric telescopic frame and a detection module, the electric telescopic frame is positioned on one side of a hematology analyzer main body and is connected with a base, a plurality of clamping grooves I are formed in the electric telescopic frame, and the detection module is connected with the electric telescopic frame. An extraction needle cylinder is detachably installed in the first clamping groove, an extraction needle head is arranged at one end of the extraction needle cylinder, a piston is movably connected to the interior of the extraction needle cylinder in a sealed mode, the detection cylinder is driven to descend through stretching and retracting of the electric telescopic frame, and in the descending process of the detection cylinder, after the detection module detects the layering position of plasma and blood cells, the extraction needle head is connected to the extraction needle cylinder; the controller controls the electric telescopic frame to move, at the moment, the push rod is pulled, the extraction needle head is just located above the layering position, the plasma is extracted into the needle cylinder, one-time plasma extraction is achieved through accurate detection of the detection module, and waste of the plasma is reduced as much as possible.

The invention discloses a hematology analyzer and a platelet numerical value measuring method, in the hematology analyzer, an analysis unit is used for receiving a pulse signal to generate a first image, receiving an optical signal to generate a second image, obtaining a platelet original numerical value based on the first image, obtaining an interference coefficient of a leukocyte fragment based on the second image, and obtaining the platelet numerical value based on the interference coefficient; and obtaining a platelet measurement value based on the platelet original value and the interference coefficient. Through the cooperation of the impedance module and the flow fluorescence module, the platelet original value in the blood cell sample and the interference coefficient of the leukocyte fragment are detected, and the accuracy of each step in the calculation process of the platelet measurement value is ensured. Meanwhile, the platelet measurement numerical value is calculated through the analysis unit based on the platelet original numerical value and the interference coefficient, so that the accuracy of the blood cell analyzer for measuring the platelet measurement numerical value is improved, the practicability of the blood cell analyzer is improved, and the use experience of a user on the blood cell analyzer is improved.

The invention relates to the technical field of electromagnetic compatibility (EMC) design of electronic circuits, in particular to a method suitable for a flow cytometer and capable of reducing interference of clock signals on EMC. The method comprises the steps that S100, clock circuit components are concentrated in a 5mm * 5mm area of the top layer of a PCB, routing is limited to a second layer through buried holes, and fundamental frequency is dynamically set; s200, laying copper in a key area for grounding, and adding a ground bounce suppression array to three layers; s300, arranging an upper ground copper layer and a lower ground copper layer by using a flexible circuit board; s400, covering the top circuit with a ferrite alloy cover, and welding and grounding; and S500, the flow velocity and the cell density are collected in real time, the clock frequency is dynamically adjusted, a frequency stabilization mechanism exists in an extreme scene, radiation is effectively reduced, and the detection precision and stability are improved. According to the method, the EMC interference of the clock signal of the flow cytometer is reduced from multiple dimensions of source inhibition, shielding protection, connection optimization and cooperative control.

The invention belongs to the field of medicines, and particularly relates to an in-vitro evaluation model for promoting skin wound healing based on a VPA-Exo drug-loaded exosome as well as a construction method and application of the in-vitro evaluation model. The construction method of the in-vitro evaluation model for promoting skin wound healing comprises the following steps: S1, after passage of resuscitated HSF cells and HUVEC cells, taking HSF cells or HUVEC cell suspension in a logarithmic phase, inoculating the HSF cells or HUVEC cell suspension on a culture plate, and culturing on a real-time label-free cell analyzer for 20-28 hours; and S2, then adding VPA-EXO with the concentration of 12.5 mu g / mL-400 mu g / mL to act on the HSF cells or the HUVEC cells.

The invention discloses a hematology analyzer and a detection method for hole blockage of a flow chamber, in the hematology analyzer provided by the invention, in the process that sample liquid enters the flow chamber for sample detection, a control unit can also obtain signal parameters based on optical signals of the sample liquid flowing through the flow chamber; whether the flow chamber is blocked or not is judged, the safety of the flow chamber is improved, and the detection efficiency of an optical detection system on sample liquid is improved. Meanwhile, in the process of detecting the sample liquid, whether the flow chamber has the hole blocking problem or not can be judged, the step of judging the hole blocking of the flow chamber does not need to be additionally set, the operation efficiency of the hematology analyzer is improved, and the use experience of a user on the hematology analyzer is improved.

The application discloses a blood cell analyzer and a processing method of a red blood cell sample. In the blood cell analyzer, a control module grades the agglomeration degree of the red blood cell sample, and then processes the red blood cell sample according to the corresponding grade based on the agglomeration degree grade of the red blood cell sample, to obtain a detection result of the red blood cell sample. The control module can intelligently grade the agglomeration degree of the red blood cell sample, and process the red blood cell sample according to the corresponding grade based on the agglomeration degree grade of the red blood cell sample, so that the blood cell analyzer can automatically process the agglutinated red blood cell sample, the agglomeration effect of the red blood cell sample is reduced, the detection accuracy of the blood cell analyzer for the red blood cell sample is improved, the probability of missing detection in the manual report auditing process is reduced, the workload of manual disposal is reduced, time for accurately and quickly issuing a detection report is saved, and the user experience of the blood cell analyzer is improved.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, the first bearing position is arranged on the sample injection module to bear the detection card for receiving the first to-be-detected sample, and the second bearing position is arranged on the first detection module to bear the detection card after receiving the first to-be-detected sample, so that the receiving and detection of the first to-be-detected sample are separately carried out at different bearing positions of different modules; the transfer module is arranged at the output end of the driving module of the preprocessing module, so that the driving module can drive the transfer module to transfer the detection card from the first bearing position to the second bearing position after driving the pipetting consumable through the loading module to transfer the first to-be-detected sample into the detection card at the first bearing position; therefore, the driving module is ingeniously used for driving the transfer module, and a driving device special for driving the transfer module is avoided, so that the overall structure of the analyzer is simpler, the production cost is reduced, and the analyzer is more compact and miniaturized in structure.

The invention is applicable to the field of cell analysis equipment, and discloses an optical detection device and a cell analyser, the optical detection device comprises a flow chamber, a light source and a forward scattering detection assembly, the forward scattering detection assembly is used for collecting forward scattering signals generated when the light source irradiates to-be-detected cells, and the forward scattering signals are sent to the flow chamber; the forward scattering detection assembly comprises a first focusing lens, a diaphragm assembly and a first detector, and the diaphragm assembly is arranged between the first focusing lens and the first detector; the first focusing lens is arranged between the flowing chamber and the diaphragm assembly, so that forward scattering light generated when the light source irradiates to-be-detected cells is converged and then penetrates through the diaphragm assembly to enter the first detector, the first focusing lens is a spherical lens, and the number of the first focusing lens is one. The single spherical lens is adopted to collect forward scattering signals and gather the forward scattering signals to the first detector, so that the size and the cost of the optical detection device are effectively reduced, and the miniaturization design of the cell analyzer is facilitated.

The hematology analyzer comprises a main machine and a puncture device, a front face cover is fixedly arranged at the front end of the main machine, a sampling groove of a concave structure is formed in the edge of the lower end portion of the front face cover, and the puncture device is fixedly arranged in the upper end portion of the front face cover. A sampling needle of the puncture device can vertically and downwards extend out of the front mask into the sampling groove; the control end of the puncture device is electrically connected with the host; a sampling key or a puncture test tube adapter is arranged on the inner wall of the sampling groove, and the sampling key or the puncture test tube adapter is electrically connected with the host. Compared with the prior art, the utility model realizes the switching between an automatic sampling mode and a manual sampling mode, and has the advantages of flexible conversion, stronger independence, convenience in installation and adjustment, efficient and convenient sampling and low cost; and operation is convenient, size is small, parts are few, and maintenance is convenient.

This application provides a method for using a POCT hematology analyzer, comprising: in response to a reagent kit being placed in a test chamber, controlling a pipette to move above the first mounting head reservoir of the reagent kit and descending to load the first mounting head; controlling the pipette to move to the diluent reservoir of the reagent kit to transfer the diluent into the pre-cell for impedance detection; controlling the pipette to transfer a sample into the pre-cell; mixing the test solution in the pre-cell; controlling the metal shielding cap to close with the test chamber to establish a connection between the rear cell and the pressure building system of the reagent kit; controlling the pressure building system to guide the test solution from the pre-cell into the rear cell; and detecting the test solution by impedance detection.

To reduce a work load by shortening a moving distance of an operator.SOLUTION: A composite analysis system 1 includes: a blood cell analyzer 2; a blood coagulation measurement device 3; and a transport device 4 having a transport path 50. The blood cell analyzer 2, the blood coagulation measurement device 3, and the transport device 4 are arranged at a position and orientation that allow at least one of access to a power supply operation reception unit of the blood cell analyzer 2 and the blood coagulation measurement device 3 from one side along the transport path 50, access to a consumable item setting unit of the respective devices from one side along the transport path 50, access to a terminal device of the respective devices from one side along the transport path 50, and access to a maintenance management target unit of the respective devices from one side along the transport path 50.SELECTED DRAWING: Figure 1

1. The name of the design product: fluorescent in situ imaging cell analyzer. 2. The use of the design product: the design product is used for measuring cell concentration and activity, and belongs to the field of biological automatic analysis instrument. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses a portable cell analyzer. A to-be-detected sample is directly sucked through a capillary tube, and a scattering signal and a fluorescence signal are excited in the capillary tube by using an optical assembly; therefore, at least two groups of scattering assemblies integrated at different spatial positions and a fluorescence detection assembly with a plurality of detection channels are used for processing detection signals of the channels respectively, so that detection results are displayed in a display device of the equipment. Complex liquid flow control of sheath liquid in the detection process in the prior art can be avoided, and at least two groups of scattering assemblies and a fluorescence detection assembly with a plurality of detection channels are respectively integrated in different spatial positions of an optical engine in the system so as to further compress a mounting space required by the system; therefore, under the condition that only a single laser module is configured, not less than five channel detection parameters are realized on the desktop, and only little waste liquid is generated. The device is easy to operate, efficient in detection, small in size, convenient to carry, install and manage by a user and low in maintenance cost.

This utility model belongs to the technical field of blood cell analyzers, specifically relating to an isolation chamber device for a blood cell analyzer. It includes an isolation chamber body, a waste liquid outlet fixedly connected to the lower outer side of the isolation chamber body, a mixing gas inlet fixedly connected to the upper outer side of the isolation chamber body, a top cover fixedly connected to the upper side of the isolation chamber body, a reaction tank connection port fixedly connected to the upper side of the top cover, a filter body fixedly connected inside the isolation chamber body, a fixed blocking part fixedly connected inside the isolation chamber body opposite to the mixing gas inlet, a buoyancy component and a movable blocking part connected to the buoyancy component, which, when the buoyancy component rises, moves an airbag to the mixing gas inlet to seal it. This utility model can reduce the phenomenon of liquid from inside the isolation chamber body entering the mixing gas inlet.

1. Name of the design product: flow chamber. 2. Use of the design product: flow chamber is configured to contain cell material analyzed by a cell analyzer. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

A quality control method for a blood cell analyzer and the blood cell analyzer are disclosed. The method comprises: obtaining a blood sample; adding a reagent to the blood sample for treatment to obtain a treated blood sample; transporting the treated blood sample to a detection device for testing to obtain measurement results of measurement parameters; and monitoring the blood cell analyzer for abnormalities based on the measurement results of the measurement parameters. This application utilizes blood samples to monitor the status of the blood cell analyzer in real time, eliminating the need for additional quality control materials and reducing monitoring costs.

Disclosed in the present application is a POCT hematology analyzer. The POCT hematology analyzer comprises: a cell counting assembly movable relative to a reagent kit, wherein the cell counting assembly comprises a main body provided with a front chamber and a rear chamber; a microporous sheet configured to isolate the front chamber from the rear chamber and provided with a micropore, the front chamber being in communication with the rear chamber by means of the micropore; and a first electrode, which penetrates and is arranged in the rear chamber and configured to be electrically connected to a test sample in the rear chamber, wherein the range of the shortest distance between the portion of the first electrode that penetrates and is arranged in the rear chamber and the micropore is 2-20 mm. By the above means, it is possible to prevent the first electrode from being too far away from or too close to the micropore, thereby reducing interference from other cells, minimizing bubble formation, and accordingly improving the accuracy of test results of the POCT hematology analyzer.

The invention discloses a liquid electric resonance real-time label-free cell analyzer, and relates to the technical field of cell analyzers, the liquid electric resonance real-time label-free cell analyzer comprises an analyzer main body, the outer side of the analyzer main body is provided with an automatic clamping mechanism, the automatic clamping mechanism comprises a movable frame, the inner wall of the movable frame is fixedly connected with a bearing, the inner ring of the bearing is fixedly connected with a stepping motor, and the stepping motor is fixedly connected with a motor shaft. The liquid electric resonance real-time label-free cell analyzer comprises an analyzer main body, a stepping motor is fixedly connected to the outer surface of the analyzer main body, a rotating column is fixedly connected to the output end of the stepping motor, two first sliding guide rails are fixedly connected to the outer surface of the analyzer main body, and a first electric telescopic rod is fixedly connected to the inner wall of each first sliding guide rail. The micro pump drives the pancreatin solution to be sprayed out, the cell culture plate can be soaked and washed in all directions, waste liquid is synchronously recycled to the waste liquid recycling box through the liquid suction head, a closed loop of cleaning and recycling is formed, the cell culture plate does not need to be manually disassembled, and residual sample pollution can be effectively avoided.

The invention relates to a blood cell analyzer and a blood cell analysis method. Sucking a to-be-detected blood sample; mixing a part of the blood sample to be detected, a hemolytic agent and a first fluorescent staining agent to prepare a first measurement sample, and detecting first optical information of particles in the first measurement sample; mixing the other part of the blood sample to be measured, the diluent and a second fluorescent staining agent to prepare a second measurement sample, and detecting second optical information of particles in the second measurement sample; acquiring first leukocyte classification information based on the first optical information; when it is judged that classification abnormity exists in the first leukocyte classification scatter diagram, second leukocyte classification information is obtained based on the second optical information, and the second leukocyte classification information is used for correcting the first leukocyte classification information. According to the invention, an accurate leukocyte classification result can be obtained.

This application relates to a blood cell analyzer and a red blood cell detection method. The blood cell analyzer includes: a sampling device for aspirating a blood sample to be tested; a sample preparation device for mixing a portion of the blood sample to be tested with a diluent to prepare a test sample; an impedance detection device including a counting cell and a detection component, wherein the counting cell is for the test sample to pass through, and the detection component is for acquiring the electronic signals of each particle in the test sample as it passes through the counting cell; and a processor configured to: acquire raw red blood cell volume distribution information based on the electronic signals of each particle in the test sample; acquire red blood cell agglutination information based on the raw red blood cell volume distribution information; and obtain the red blood cell count value of the blood sample to be tested based on the raw red blood cell volume distribution information and the red blood cell agglutination information. This enables the acquisition of an accurate red blood cell count value.

The application is suitable for the field of cell analysis equipment, and discloses an optical detection device and a cell analyzer. The optical detection device comprises a flow chamber, a light source and a forward scattering detection assembly. The forward scattering detection assembly is used for collecting a forward scattering signal generated by the light source irradiating on a cell to be measured. The forward scattering detection assembly comprises a first focusing lens, an aperture assembly and a first detector. The aperture assembly is arranged between the first focusing lens and the first detector. The first focusing lens is arranged between the flow chamber and the aperture assembly, so as to make forward scattering light generated by the light source irradiating on the cell to be measured converge and then pass through the aperture assembly to enter the first detector. The first focusing lens is a spherical lens, and the number of the first focusing lens is one. The single spherical lens is used for collecting the forward scattering signal and converging the forward scattering signal on the first detector, so that the volume and cost of the optical detection device are effectively reduced, and the miniaturization design of the cell analyzer is facilitated.

The present invention is applicable to the field of medical equipment, and discloses a cell analyzer and a detection method for the cell analyzer. The cell analyzer includes a sampling component, an optical channel reaction pool, an optical detection unit, a hemoglobin detection unit, an impedance counting detection unit, a first reagent providing device, a second reagent providing device, a diluent providing device, a conveying pipeline assembly and a fluid power device. The fluid power device includes a first syringe and a second syringe. The range of the first syringe is smaller than the range of the second syringe. The second syringe is used to drive the optical detection sample from the optical channel reaction pool to the optical sample preparation pipeline. The first syringe is used to provide power for sample aspiration, sample separation and sample pushing. The second syringe is used to provide power for diluent delivery to the flow chamber, diluent delivery to the hemoglobin detection unit, diluent delivery to the impedance counting detection unit and sample preparation. The present invention greatly reduces the cost and volume of the instrument.

The present invention relates to the technical field of cell analyzers, and discloses an animal cell immunocompetence analyzer, which comprises: a housing, the upper end of which is provided with a display operation screen, the front end of which is provided with a reagent plate docking port, the reagent plate docking port is internally provided with a telescopic reagent plate receiving member for receiving an animal cell reagent plate, the side wall of which is provided with a discharge port, and the side wall of which is correspondingly provided with a collection box; the coaxial integrated bias analysis area is arranged in the shell, and a central positioning column vertically extending is arranged in the center of the coaxial integrated bias analysis area. According to the invention, through the circumferential layout of the coaxial integrated bias analysis area and the equidistant distribution of the plurality of independent incubation units, synchronous incubation and detection of multiple samples are realized; the movable inner cores are accurately conveyed through the transfer conveying piece and the conveying separation piece, the single-time operation efficiency is improved, and the efficiency bottleneck of serial processing of traditional equipment is solved.

The application designs a three-dimensional flow cytometer and method based on optical detection and ICP-MS combination, relates to the technical field of life analysis scientific detection equipment; first, a three-dimensional flow cytometer is provided, a three-dimensional flow cytometer method based on optical detection and ICP-MS combination is designed based on the analyzer, and the flow cytometer can only perform single-parameter flow cytometer analysis of fluorescence, scattering and mass spectrum or multi-parameter flow cytometer analysis in any combination; the data processing software in the analyzer can provide offline processing of flow cytometer analysis data of fluorescence, side scattering light and mass spectrum, identify, calculate and statistically analyze single-cell pulse signals, especially can provide integration and unification among fluorescence, side scattering and mass spectrum single-cell signals, and obtain three-parameter information of the same cell.

The invention relates to the field of medical instruments, and discloses a pressure-flow rate cooperative control method and system, and the method comprises the steps: obtaining standardized operation data of a flow cytometer fluid path; constructing a liquid path sparse Bayesian causal graph structure; performing feature screening and weight addition on the sparse Bayesian causal graph structure of the liquid path to obtain a multi-level risk probability of each time window; adjusting the importance coefficient of nodes in the liquid path sparse Bayesian causality graph structure by using the multi-level risk probability; using a liquid path sparse Bayesian causal graph structure to constrain the reinforcement learning strategy space to obtain a liquid path parameter adjustment suggestion; a liquid path parameter adjustment suggestion is combined with PID control to form a pressure and flow rate dual-target adaptive control instruction set; and executing the adaptive control instruction set, and driving continuous evolution of the liquid path parameter adjustment suggestions. According to the invention, the flow velocity is stable, the repeatability of cell concentration, absolute counting and signal intensity is improved, and high-quality quantitative analysis is supported.

1. Name of the designed product: full-automatic five-classification blood cell analyzer. 2. Use of the designed product: for analyzing blood. 3. Design points of the designed product: in the shape of the product. 4. Picture or photo best indicating the design points: perspective view 1.

The present application provides a POCT blood cell analyzer, including a detection seat, a pipette arranged above the detection seat, and a pressure building system, wherein the detection seat is used to receive a test kit, and the test kit is provided with a front pool and a rear pool connected by micropores, and the pressure building system includes a pressure chamber, an air pressure connection device, a first syringe, a second syringe, and a driving member, the air pressure connection device is connected to the pressure chamber, and is used to apply positive pressure or negative pressure to the front pool or the rear pool to enable the liquid in the front pool to flow to the rear pool; the first syringe is connected to the pressure chamber / pipette, and is used to establish positive pressure or negative pressure in the pressure chamber, and is also used to assist the pipette in pipetting, or to bubble and mix the liquid in the front pool; the second syringe is connected to the pipette for pipetting; and the driving member is used to drive the first syringe and the second syringe at the same time.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, a first bearing position is arranged on a sample introduction module and used for bearing a detection card, a second bearing position is arranged on a first detection module and used for bearing the detection card, and a first sample to be detected is transferred into the detection card located at the first bearing position through a pretreatment module; and transferring the detection card receiving the first to-be-detected sample at the first bearing position to the second bearing position through a transfer module, and detecting the settled first to-be-detected sample in the detection card at the second bearing position through the microscope unit, therefore, each detection card receives the first to-be-detected sample and the detection of the first to-be-detected sample after settlement is carried out at different bearing positions, so that the detection efficiency of the POCT hematology analyzer can be effectively improved.

1. The name of the design product: cell analyzer. 2. The use of the design product: cell analyzer is configured to analyze the input cell material. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention relates to the technical field of hematology analyzers, and discloses a cell analyzer sample introduction device which comprises a machine body, a detection cavity, a feeding drawer, a hydraulic cylinder and a sample introduction calibration module, and a bin door is hinged to the front face of the machine body. The stable and controllable driving force is provided through the electric push rod and transmitted to the single rack through the push block, the synchronous gear is matched to synchronously and symmetrically transmit the movement to the rack on the other side, clear guide is provided for placement, stable circumferential constraint is formed after clamping, and the clamping precision is improved. The test tubes are effectively prevented from deviating or shaking in the horizontal direction possibly in the subsequent conveying process, the problem that due to manual placement errors or mechanical conveying gaps, the positions of the test tubes on the horizontal plane are uncertain is solved, and therefore radial dislocation of the test tubes and puncture needles at the final detection station is avoided; the problems that the puncture needle cannot accurately pierce into the preset position of the test tube, sampling fails and even the precise puncture needle is damaged are solved.