26 results about "Hematology analyzers" patented technology

The invention discloses a hematology analyzer and a detection method for hole blockage of a flow chamber, in the hematology analyzer provided by the invention, in the process that sample liquid enters the flow chamber for sample detection, a control unit can also obtain signal parameters based on optical signals of the sample liquid flowing through the flow chamber; whether the flow chamber is blocked or not is judged, the safety of the flow chamber is improved, and the detection efficiency of an optical detection system on sample liquid is improved. Meanwhile, in the process of detecting the sample liquid, whether the flow chamber has the hole blocking problem or not can be judged, the step of judging the hole blocking of the flow chamber does not need to be additionally set, the operation efficiency of the hematology analyzer is improved, and the use experience of a user on the hematology analyzer is improved.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, the first bearing position is arranged on the sample injection module to bear the detection card for receiving the first to-be-detected sample, and the second bearing position is arranged on the first detection module to bear the detection card after receiving the first to-be-detected sample, so that the receiving and detection of the first to-be-detected sample are separately carried out at different bearing positions of different modules; the transfer module is arranged at the output end of the driving module of the preprocessing module, so that the driving module can drive the transfer module to transfer the detection card from the first bearing position to the second bearing position after driving the pipetting consumable through the loading module to transfer the first to-be-detected sample into the detection card at the first bearing position; therefore, the driving module is ingeniously used for driving the transfer module, and a driving device special for driving the transfer module is avoided, so that the overall structure of the analyzer is simpler, the production cost is reduced, and the analyzer is more compact and miniaturized in structure.

The utility model discloses a built-in hemolytic agent bottle and hematology analyzer relates to medical instrument technical field, wherein the built-in hemolytic agent bottle includes solvent bottle, movable joint block and pipeline subassembly, solvent bottle includes mutually communicated bottle body and bottle cap, bottle body and bottle cap detachable connection, bottle cap far away from bottle body side is equipped with the movable mouth; the movable connector block is movably arranged at the movable opening, the movable connector block and the movable opening are arranged in a clearance mode, and the movable connector block is provided with a mounting hole which is formed in the thickness direction in a penetrating mode; the pipeline assembly is fixedly arranged at the mounting hole, one end of the pipeline assembly extends into the bottle body, and the other end of the pipeline assembly penetrates out of the mounting hole and is communicated with an external liquid system. According to the technical scheme, the problem that when a bottle cap of an existing built-in hemolytic agent bottle is screwed down, a pipeline is prone to being bent is solved.

A computer-implemented method for determining states in vivo and in vitro by analyzing blood parameters, including obtaining blood parameters of a blood sample by a hematology analyzer, the blood parameters including quantitative and qualitative measurement variables, and the measurement variables include properties of individual cells, and the individual cells comprise blood cells. The computer-implemented method further includes creating a scatterplot having at least two axes, and each axis of the scatterplot comprises a different measurement variable; and determining an in-vivo and / or in-vitro and / or post-mortem state by a deep learning model and / or a machine learning model. The input variable for the deep learning model includes a scatterplot, and the input variable for the machine learning model includes 1D vector. The 1D vector is created by vectorizing the scatterplot; and automatically generating a report including the result regarding the determination of the state.

The present invention provides a method of identifying and mitigating a risk of deathloss of an animal, comprising receiving, at a processor from a hematology analyzer, information obtained from a sample from said animal, wherein said information comprises a leukocyte absolute count and a leukocyte differential from said sample, said sample comprising leukocytes, analyzing, by said processor, said leukocyte absolute count and said leukocyte differential to determine a survivability index for said animal, and managing the animal based on the survivability index.

Disclosed in the present application is a POCT hematology analyzer. The POCT hematology analyzer comprises: a cell counting assembly movable relative to a reagent kit, wherein the cell counting assembly comprises a main body provided with a front chamber and a rear chamber; a microporous sheet configured to isolate the front chamber from the rear chamber and provided with a micropore, the front chamber being in communication with the rear chamber by means of the micropore; and a first electrode, which penetrates and is arranged in the rear chamber and configured to be electrically connected to a test sample in the rear chamber, wherein the range of the shortest distance between the portion of the first electrode that penetrates and is arranged in the rear chamber and the micropore is 2-20 mm. By the above means, it is possible to prevent the first electrode from being too far away from or too close to the micropore, thereby reducing interference from other cells, minimizing bubble formation, and accordingly improving the accuracy of test results of the POCT hematology analyzer.

The disclosure features calibration fluids that include a plurality of beads, such as cellulose, silica, poly(methyl-methacrylate) (PMMA), melamine, cross-linked agarose, polyvinylacetate (PVA), and / or polystyrene beads, where the beads are sized and colored to represent at least one type of blood cell; and a carrier fluid, that can include a polymer or polymerizing matrix, e.g., a water-soluble resin, e.g., an acrylic or polyurethane water-soluble resin or a starch or a cellulose, serum, and / or one or more or sugars. The disclosure also features methods of using the calibration fluids to calibrate automated sample preparation systems, such as automated hematology analyzer systems, e.g., image-based hematology analyzer systems.

This invention describes a method for preparation of stable hematology reference materials by producing synthetic hydrogel blood cell surrogates, which mimic human blood components in size, morphology, performance and functionality when analyzed using an automated hematology analyzer employing multiple detection technologies. Different hydrogel particles can be combined and mixed to prepare multi-parameter and multi-level hematology reference materials, which could be used for calibration, linearity verification, proficiency evaluation, and routine performance monitoring of modern automated hematology analyzers. These hydrogel particles can also be combined with processed and stabilized human blood components to prepare the reference materials of this invention.

This invention relates to the field of hematology analysis technology, and in particular to a diluent for hematology analysis, its preparation method, and its uses. The diluent comprises the following components: 0.5-15 g / L of inorganic salt, 0.01-5.0 g / L of preservative, and 0.1-0.5 g / L of stabilizing agent; the solvent of the diluent is water; the diluent also includes an anti-precipitant, selected from one or more of salt-based and organic anti-precipitants; the salt-based anti-precipitant includes one or more of thiocyanate and nitrate, with a content of 2.0-5.0 mmol / L; the organic anti-precipitant includes one or more of trehalose, mannitol, and amino acid ionic liquids, with a content of 4.0-8.0 mmol / L. In this diluent, the components work synergistically to reduce the maintenance cost of the hematology analyzer, increase its service life, and improve detection efficiency.

The application discloses a POCT hematology analyzer and a hematology analysis method, the POCT hematology analyzer performs pressure detection on a detection cell through a pressure buildup mechanism in the detection process of a kit, and a processor judges whether the airtightness of the detection cell is abnormal according to the pressure detection result of the pressure buildup mechanism; the kit can be treated in time when the air tightness of the detection cell is abnormal, so that the damage of the kit to the POCT hematology analyzer due to the problems of air leakage or hole blockage and the like is reduced, and the detection accuracy and reliability of the POCT hematology analyzer are improved.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, a first bearing position is arranged on a sample introduction module and used for bearing a detection card, a second bearing position is arranged on a first detection module and used for bearing the detection card, and a first sample to be detected is transferred into the detection card located at the first bearing position through a pretreatment module; and transferring the detection card receiving the first to-be-detected sample at the first bearing position to the second bearing position through a transfer module, and detecting the settled first to-be-detected sample in the detection card at the second bearing position through the microscope unit, therefore, each detection card receives the first to-be-detected sample and the detection of the first to-be-detected sample after settlement is carried out at different bearing positions, so that the detection efficiency of the POCT hematology analyzer can be effectively improved.

The invention relates to the technical field of hematology analyzers, and discloses a cell analyzer sample introduction device which comprises a machine body, a detection cavity, a feeding drawer, a hydraulic cylinder and a sample introduction calibration module, and a bin door is hinged to the front face of the machine body. The stable and controllable driving force is provided through the electric push rod and transmitted to the single rack through the push block, the synchronous gear is matched to synchronously and symmetrically transmit the movement to the rack on the other side, clear guide is provided for placement, stable circumferential constraint is formed after clamping, and the clamping precision is improved. The test tubes are effectively prevented from deviating or shaking in the horizontal direction possibly in the subsequent conveying process, the problem that due to manual placement errors or mechanical conveying gaps, the positions of the test tubes on the horizontal plane are uncertain is solved, and therefore radial dislocation of the test tubes and puncture needles at the final detection station is avoided; the problems that the puncture needle cannot accurately pierce into the preset position of the test tube, sampling fails and even the precise puncture needle is damaged are solved.

This utility model relates to medical diagnostic equipment and in vitro laboratory diagnostics, including microfluidic impedance cytometers for rapid assessment of the white blood cell (WBC) count in whole blood. It can be used in automated systems for calculating biological age based on telomere indices (T / S) and / or associated biomarkers. The technical result is the elimination of biological age (BA) bias arising from interindividual differences in the white blood cell count (proportion of granulocytes and lymphocytes), without the use of a separate blood analyzer, thanks to integrated multi-frequency impedance classification of WBC and automatic transfer of the calculated proportions to the telomere computing circuit (TEL-BA / BA-Dock) for T / S → BA regression correction.The technical result is achieved in that the impedance microcytometer "WBC-Adjust" is made in the form of an embedded (inline) micromodule installed downstream of the qPCR cartridge, and contains a microfluidic channel with a hydrodynamic focusing system, an array of measuring electrodes connected to a multi-frequency impedance meter, an electronic unit for classifying cells according to a set of "size-multi-frequency dielectric profile" features, a communication interface (wired / wireless) for transmitting calculated WBC shares to the TEL-BA / BA-Dock, as well as a controller implementing self-testing protocols, temperature monitoring and synchronization with the main measuring cycle of the telomeric cartridge.

The utility model discloses a hematology analyzer which comprises a frame body, a power supply assembly, a control circuit board, a reagent supply assembly, an automatic sample injection assembly and a blood routine examination assembly, a first open cavity, a middle wiring cavity and a second open cavity are sequentially formed in the middle of the frame body; the power supply assembly is arranged on the rear end face of the frame body, the control circuit board is arranged at the top of the frame body, the reagent supply assembly is arranged in the second open cavity and on the front end face of the frame body, the automatic sample injection assembly is arranged on the front end face of the frame body, and the blood routine examination assembly is arranged in the first open cavity; the control circuit board is electrically connected with the power supply assembly, the reagent supply assembly, the automatic sample injection assembly and the blood routine examination assembly; the reagent supply assembly is connected with the blood routine examination assembly. According to the utility model, modularized components are adopted, and the components are reasonably arranged, so that the production and assembly efficiency can be improved, and the maintenance is easy.

The invention discloses an integrated three-dimensional sheath flow channel integrated learning hematology analyzer and method, and belongs to the technical field of single cell detection.The integrated three-dimensional sheath flow channel integrated learning hematology analyzer comprises a blood sample preprocessing module, a signal detection module, a data processing module and a leukocyte classification counting result display module.The integrated three-dimensional sheath flow channel manufactured by the method is high in precision and good in depth-to-width ratio; the conductive sample liquid is surrounded by the insulating sheath liquid, so that leakage current can be effectively reduced, and an electrical signal generated when cells pass through a focusing area is enhanced; an equivalent model is used for extracting inherent electrical structure features of the cells, a neural network is used for extracting hidden features, and the precision, generalization and interpretability of a cell classification algorithm can be effectively balanced through combination of the two features; normal leukocytes can be detected, abnormal leukocytes can be classified and counted, more information and insights can be provided for clinic, and diagnosis of blood diseases is helped.

The utility model provides a kind of blood cell analyzer, including sampling component, processing component, detection component and analysis component, sampling component includes sampling needle, sampling driving part, first pipeline, second pipeline, third pipeline, first switching structure, liquid discharge driving part and atmospheric communication part, wherein, the both ends of first pipeline are connected with sampling needle and first switching structure respectively, the both ends of second pipeline are connected with first switching structure and sampling driving part respectively, the both ends of third pipeline are connected with first switching structure and liquid discharge driving part respectively, atmospheric communication part can communicate third pipeline and atmosphere, first switching structure has first working state and second working state, so that sampling needle is inserted into closed test tube, closed test tube can be communicated with atmosphere by sampling needle, first pipeline and third pipeline and pressure relief when inserting sampling needle into closed test tube.The technical scheme of the application can effectively solve the problem of high cost and difficult to clean of the sampling needle in related technology.

The utility model relates to the technical field of cell analysis, and provides a sampling device of a hematology analyzer, which comprises an analyzer body, a probe is arranged at the top end of the analyzer body, a bottom plate is arranged at the bottom end of the analyzer body, and positioning blocks are fixedly connected to two sides of the upper surface of the bottom plate. The sides, close to each other, of the two positioning blocks are rotationally connected with the same two-way lead screw, one sides of the positioning blocks are fixedly connected with servo motors, the servo motors penetrate through the positioning blocks and are fixedly connected with one ends of the two-way lead screws, and the arc surface of each two-way lead screw is in threaded connection with two moving blocks. And the inner walls of the two moving blocks are rotationally connected with driving rods. The sampling device of the hematology analyzer solves the technical problem that the overall practicability and the application range of the equipment are influenced as part of catheters cannot be stably fixed and detected due to the lack of the function of adjusting the length of the catheters in the conventional equipment.

The invention discloses a POCT hematology analyzer. The POCT hematology analyzer comprises a shell; the loading seat is used for receiving the loading of the kit; the blood cell counting mechanism is arranged in the shell and can move relative to the kit; the blood cell counting mechanism includes: a body; the liquid suction part is matched with the main body to form a liquid suction channel for conveying liquid; the liquid discharging part is matched with the main body to form a liquid discharging channel for discharging liquid of the main body; and when the liquid suction channel is blocked, the blood cell counting mechanism is arranged to impact the liquid suction channel through gas in the main body, or suck liquid through the liquid discharge piece and impact the liquid suction channel through the liquid. According to the mode, the liquid suction channel is impacted by gas or liquid, so that the accuracy of a detection result of the POCT blood cell analyzer is improved; the microporous sheet of the blood cell counting mechanism does not need to be frequently replaced, the use time of the microporous sheet is delayed, and the cost is reduced.

1. The name of the design product: blood cell analyzer. 2. The use of the design product: for counting blood cells and detecting related items. 3. The design points of the design product: in the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to the technical field of hematology analyzers, in particular to a biosafety hematology analyzer which comprises a sealing assembly used for sealing the punctured end of a blood test tube, the sealing assembly comprises a lead screw, the surface of the lead screw is in meshed connection with a sleeve, and the sleeve is in sliding fit with the inner wall of a cavity through a strip-shaped rod. An elastic telescopic rod is fixedly installed at the upper end of the sleeve, a sealing gasket is fixedly connected to the upper end of the elastic telescopic rod, a puncture needle is arranged below the sealing gasket, and the puncture needle is fixedly installed at the upper end of the sleeve. According to the invention, through cooperative use of all parts, during sampling, generation of a wall hanging phenomenon can be prevented, at the same time, it can be ensured that aerosol does not appear during sampling, and the accuracy of a detection result is ensured.

The utility model relates to the technical field of blood cell analysis, in particular to a trace whole blood sample collection tube and a blood cell analyzer. According to the trace whole blood sample collecting tube provided by the utility model, the magnetic beads are arranged to scatter liquid drops in an inverted uniform mixing process of trace whole blood, so that the liquid flowing stroke in the uniform mixing process can be increased, and the uniform mixing effect is improved; the trace whole blood sample collecting tube provided by the utility model can be further matched with a magnet to be applied to a hematology analyzer, so that the magnetic beads are attracted by the magnet to be fixed on the tube wall of the collecting tube in a trace whole blood sample injection process, and the influence on sample injection of a sample injection needle or the blockage of a liquid path are avoided; wherein the trace whole blood sample collection tube and the magnet are low in cost, but can improve the uniform mixing variable coefficient of a blood routine project, and have a wide application prospect.

The present disclosure provides a kit assembly device for a blood cell analyzer. The kit assembly device for a blood cell analyzer comprises a conveying frame, a microwell sheet screening mechanism, a first visual detection member and a suction mechanism. The microwell sheet screening mechanism comprises a first feeding disc, a first feeding support, a moving screening assembly, a second feeding support and a collection box. The first feeding disc is located on one side of the conveying frame. The collection box is installed on the moving screening assembly. The first visual detection member is arranged opposite to the moving screening assembly. The first visual detection member is used for detecting the microwell sheet on the moving screening assembly, so that the moving screening assembly pushes the unqualified microwell sheet into the collection box, and the moving screening assembly pushes the qualified microwell sheet into the second feeding support. The suction mechanism is used for sucking the microwell sheet in the second feeding support into the kit on the conveying belt.

The present application discloses a POCT hematology analyzer and a hematology analysis method. In the POCT hematology analyzer, a pressure buildup mechanism performs pressure detection on a test chamber during testing of a reagent cartridge; a processor determines, on the basis of the pressure detection result from the pressure buildup mechanism, whether the gas tightness of the test chamber is abnormal. Thus, the reagent cartridge can be processed in a timely manner when the gas tightness of the test chamber is abnormal, thereby reducing damage to the POCT hematology analyzer caused by problems such as gas leakage or port blockage of the reagent cartridge, and improving the test accuracy and reliability of the POCT hematology analyzer.

The invention discloses a POCT hematology analyzer. The POCT hematology analyzer comprises a shell; the loading seat is used for receiving the maintenance kit, and the maintenance kit comprises a plurality of cleaning fluid pools; the blood cell counting mechanism is arranged in the shell; the blood cell counting mechanism includes: a body; the liquid suction part is matched with the main body to form a liquid suction channel for conveying liquid; the liquid discharging part is matched with the main body to form a liquid discharging channel for discharging liquid of the main body; wherein the blood cell counting mechanism is provided with a maintenance mode, and in the maintenance mode, the blood cell counting mechanism is arranged to suck cleaning fluid from different cleaning fluid pools through the fluid suction part according to the cleaning intensity from high to low and discharge the cleaning fluid in the main body to the maintenance kit through the fluid discharge part. Through the mode, the blood cell counting mechanism is cleaned for multiple times according to the cleaning intensity from high to low in the maintenance mode, so that the accuracy of the detection result of the POCT blood cell analyzer is improved.

1. Name of the designed product: main body of biological sample diagnosis device. 2. Use of the designed product: the product as a whole is a biological sample diagnosis device, which may also be referred to as a blood sampling device, a blood testing device, a blood diagnosis device, a biological sample testing device, a hematology analyzer or a combination thereof. The claimed part is the main body of the biological sample diagnosis device. 3. Design points of the designed product: the shape, pattern or combination thereof shown in each view. 4. Picture or photo best indicating the design points: design 1 perspective view. 5. Design 1 is designated as the basic design. 6. Other circumstances needing explanation: design 1 and design 2 are partial designs, wherein the part shown in dashed line is not claimed.

The present disclosure provides methods and compositions for preparing linearity control slides to verify linearity of image-based hematology analyzers without the need to make such control slides over and over again for each analyzer each time the analyzer is verified.