A medical testing device

Abstract

The embodiment of the present application provides a medical detection device, comprising: a shell; a pressure measuring component, which is installed on the outer wall of the shell and is used for measuring the pressure of the environment outside the shell; and a concentration measuring component, which is installed on the outer wall of the shell and is used for measuring the concentration of a parameter to be measured in the environment outside the shell. The medical detection device in the embodiment of the present application can realize the detection of various parameters (including pH value, occult blood concentration, pepsin concentration and trypsin concentration) in the digestive tract, thereby improving the accuracy of the detection result of the medical detection device on the digestive tract. Meanwhile, the medical detection device can realize the measurement of the pressure in the digestive tract, thereby further improving the accuracy of the detection result. Moreover, the medical detection device can reduce the medical detection procedure and the number of devices required in the detection process, thereby saving the cost.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a medical detection device. BACKGROUND

[0002] With the acceleration of the pace of life, people's life pressure is gradually increasing, and in addition to the change of dietary structure, leading to digestive diseases has become a serious impact on people's quality of life. The diagnosis and treatment of digestive diseases are based on the accurate examination of the physiological parameters and mucosa state of the digestive tract. In addition to the state of the digestive tract mucosa, the known parameters related to the health status of the digestive tract also include the pressure of the digestive tract, the pH value and other information.

[0003] At present, the endoscope device is usually used to directly observe the mucosa of the digestive tract. However, due to the limitation of technology integration, the endoscope on the market can only observe the image of the mucosa of the digestive tract, and cannot obtain other useful information in the digestive tract. Therefore, the existing endoscope device has a single function and cannot complete the accurate detection of the digestive tract. SUMMARY

[0004] Therefore, the medical detection device provided by the embodiments of the present application can solve the problem that the endoscope device in the prior art has a single function and cannot complete the accurate detection of the digestive tract.

[0005] The medical detection device provided by the embodiments of the present application comprises:

[0006] a shell;

[0007] a pressure measuring component installed on the outer wall of the shell and used for measuring the pressure of the environment outside the shell;

[0008] a concentration measuring component installed on the outer wall of the shell and used for measuring the concentration of a to-be-measured parameter in the environment outside the shell.

[0009] In a possible design, the pressure measuring component comprises a driving part, an indicating part and an indicating agent.

[0010] The indicating part has an indicating cavity, and the indicating part is provided with a scale. When the indicating agent flows in the indicating cavity, the indicating agent can correspond to different scales.

[0011] When pressed, the driving part can drive the indicating agent to flow in the indicating cavity.

[0012] In a possible design, the driving part has a driving cavity in communication with the indicating cavity, and the driving cavity contains the indicating agent.

[0013] The driving part is pressed, the driving cavity can be deformed, and the indicator in the driving cavity can be pressed into the indicating cavity.

[0014] In a possible design, the driving part includes a pressure-sensitive membrane, and the pressure-sensitive membrane surrounds the driving cavity.

[0015] When pressed, the pressure-sensitive membrane can be deformed towards the inside of the driving cavity, and when the pressure disappears, the pressure-sensitive membrane can return to the original state.

[0016] In a possible design, the driving part and the indicating part are integrally formed, and the driving part and the indicating part both include a pressure-sensitive membrane, and the pressure-sensitive membrane surrounds the driving cavity and the indicating cavity.

[0017] The cross-sectional area of the driving cavity is greater than that of the indicating cavity.

[0018] In a possible design, the driving part includes a gas cavity and a liquid cavity, and the gas cavity and the liquid cavity are separated by a driving plate, and the volume of the gas cavity and the liquid cavity is adjusted by the movement of the driving plate.

[0019] The liquid cavity has the indicator therein, the indicator in the liquid cavity can enter the indicating cavity, and the indicator in the indicating cavity can also enter the liquid cavity.

[0020] In a possible design, the indicator is one or more of methylene blue, betacyanin, and vitamin B.

[0021] In a possible design, the concentration measuring component includes a polyion gel and a dye, and the dye is filled in the polyion gel.

[0022] The dye can change color when the concentration of the to-be-measured parameter is different.

[0023] In a possible design, the concentration measuring component includes one or more of a pH measuring component, a hidden blood measuring component, a pepsin measuring component, and a trypsin measuring component.

[0024] In a possible design, the dye of the pH measuring component is a pH-sensitive dye, and the pH-sensitive dye can change color in environments with different pH values.

[0025] In a possible design, hydrogen ions in the environment outside the shell can enter the pH measuring component through the polyion gel, and the hydrogen ions in the pH measuring component can enter the environment outside the shell through the polyion gel.

[0026] The pH-sensitive dye can combine with or separate from the hydrogen ions to form a dynamic equilibrium.

[0027] In a possible design, the dye of the occult blood measuring component includes methylene blue dye, which can change color in environments with different concentrations of occult blood.

[0028] In a possible design, hemoglobin in the environment outside the shell can bind to and react with the polyionic gel and methylene blue dye in the occult blood measuring component.

[0029] Under the action of hemoglobin, the methylene blue dye can show color through redox reaction, and the color shown by the methylene blue dye is different when the concentration of hemoglobin is different.

[0030] In a possible design, the dye of the pepsin measuring component includes bromophenol blue dye, which can change color in environments with different concentrations of pepsin.

[0031] In a possible design, pepsin in the environment outside the shell can bind to the polyionic gel and bromophenol blue dye in the pepsin measuring component.

[0032] After binding, the bromophenol blue dye changes in light scattering signal and shows different colors, and the color of the bromophenol blue dye is different when the concentration of pepsin is different.

[0033] In a possible design, the dye of the trypsin measuring component includes bromocresol purple dye, which can change color in environments with different concentrations of trypsin.

[0034] In a possible design, trypsin in the environment outside the shell can bind to the polyionic gel and bromocresol purple dye in the trypsin measuring component.

[0035] After binding, the volume of the bromocresol purple dye changes, the light scattering signal changes, and different colors are shown, and the color of the bromocresol purple dye is different when the concentration of trypsin is different.

[0036] In a possible design, the pressure measuring component and the concentration measuring component are arranged in a zoned arrangement or an alternating arrangement on the outer wall of the shell.

[0037] In a possible design, the medical detection device includes a plurality of the measuring components.

[0038] The ranges of the measuring components are not completely the same, and / or the resolutions of the measuring components are not completely the same.

[0039] In a possible design, the shell includes a transparent part.

[0040] The medical detection device further comprises an imaging component, which is located in the inner cavity of the shell and can observe the environment outside the shell through the transparent part.

[0041] In a possible design, the shell comprises a first end portion and a second end portion arranged oppositely along an axial direction, and the first end portion and the second end portion each comprises the transparent part.

[0042] The medical detection device comprises two imaging components, which are arranged correspondingly with the two transparent parts respectively.

[0043] One of the concentration measuring component and the pressure measuring component is mounted on the outer wall of the first end portion, and the other is mounted on the outer wall of the second end portion; or,

[0044] The concentration measuring component and the pressure measuring component are both mounted on the outer wall of the first end portion or the outer wall of the second end portion; or,

[0045] The outer wall of the first end portion is provided with a first concentration measuring component and a first pressure measuring component, and the outer wall of the second end portion is provided with a second concentration measuring component and a second pressure measuring component, wherein the measuring range of the first concentration measuring component is different from that of the second concentration measuring component, and the measuring range of the first pressure measuring component is different from that of the second pressure measuring component.

[0046] In a possible design, the medical detection device further comprises a data transmission assembly.

[0047] The imaging component comprises a lens and an image sensor, and the lens and the image sensor are connected through a mechanical structure and / or glue.

[0048] The image sensor is electrically or signal connected with the data transmission assembly, and the lens is connected with the data transmission assembly through a mechanical structure and / or glue.

[0049] In a possible design, the lens is mounted in the inner cavity of the shell, and has an effective imaging angle α1, and the transparent part can cover the space where the effective imaging angle α1 is located.

[0050] The image sensor has a display image angle α2, the transparent part can cover the space where the display image angle α2 is located, and α1>α2.

[0051] The concentration measuring component and / or the pressure measuring component are mounted on the outer wall of the shell and located in the space between the effective imaging angle α1 and the display image angle α2.

[0052] The data transmission component can read data of the concentration measuring component and / or the pressure measuring component.

[0053] In a possible design, the lens is mounted in the inner cavity of the shell, and the lens has an effective imaging angle α1, and the transparent part can cover a space in which the effective imaging angle α1 is located;

[0054] The image sensor has a display image angle α2, the transparent part can cover a space in which the display image angle α2 is located, and α1 > α2;

[0055] The concentration measuring component and / or the pressure measuring component are mounted on the outer wall of the shell and located in the space occupied by the display image angle α2.

[0056] The image sensor can identify data of the concentration measuring component and / or the pressure measuring component.

[0057] In a possible design, the concentration measuring component and / or the pressure measuring component are located in the middle of the space occupied by the display image angle α2.

[0058] In a possible design, the concentration measuring component is attached to the outer wall of the shell by using transparent adhesive material.

[0059] The pressure measuring component is attached to the outer wall of the shell by using transparent adhesive material.

[0060] In a possible design, the concentration measuring component is also attached to the outer wall of the shell by using edge sealing adhesive material, and the edge sealing adhesive material covers the outer edge of the measuring component.

[0061] In a possible design, the shell has a capsule structure.

[0062] The medical detection device is a capsule endoscope.

[0063] Therefore, the medical detection device in the embodiment of the present application can detect parameters (including pH value, concentration of occult blood, concentration of pepsin and concentration of trypsin, etc.) in the digestive tract by using the concentration measuring component, thereby improving the accuracy of the detection result of the medical detection device on the digestive tract. Meanwhile, the medical detection device can measure the pressure in the digestive tract by using the pressure measuring component, thereby further improving the accuracy of the detection result. The medical detection device can reduce the medical detection procedure and the number of devices required in the detection process, thereby saving cost. BRIEF DESCRIPTION OF DRAWINGS

[0064] To more clearly illustrate the technical solutions of the embodiments of this application, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0065] Figure 1 This is a schematic diagram of the structure of the medical testing equipment provided in this application in a first specific embodiment;

[0066] Figure 2 for Figure 1 Exploded view;

[0067] Figure 3 for Figure 1 A partial sectional view;

[0068] Figure 4 for Figure 1 A schematic diagram of the structure of the pressure measuring component in the first specific embodiment;

[0069] Figure 5 for Figure 4 Sectional view along axis AA;

[0070] Figure 6 for Figure 4 BB-direction sectional view;

[0071] Figure 7 for Figure 1 A schematic diagram of the pressure measuring component in the second specific embodiment;

[0072] Figure 8 for Figure 4 Schematic diagram of the medium concentration measuring component;

[0073] Figure 9 for Figure 4 A schematic diagram showing the connection between the concentration measuring component and the housing.

[0074] Figure 10 This is a schematic diagram of the structure of the medical testing equipment provided in this application in a second specific embodiment; Figure 11 This is a schematic diagram of the structure of the medical testing equipment provided in this application in a third specific embodiment;

[0075] Figure 12 This is a schematic diagram of the structure of the medical testing equipment provided in this application in a fourth specific embodiment;

[0076] Figure 13 This is a schematic diagram of the structure of the medical testing equipment provided in the fifth specific embodiment of this application;

[0077] Figure 14 A plan view of the medical testing apparatus according to the present application in a sixth embodiment;

[0078] Figure 15 A plan view of the medical testing apparatus according to the present application in a seventh embodiment;

[0079] Figure 16 A plan view of the medical testing apparatus according to the present application in an eighth embodiment;

[0080] Figure 17 A plan view of the medical testing apparatus according to the present application in a ninth embodiment.

[0081] Reference Signs:

[0082] 1 - housing

[0083] 11 - transparent portion

[0084] 12 - upper housing

[0085] 13 - lower housing

[0086] 14 - edge sealant

[0087] 2 - pressure measuring member

[0088] 21 - drive portion

[0089] 211 - drive cavity

[0090] 212 - gas cavity

[0091] 213 - liquid cavity

[0092] 22 - indication portion

[0093] 221 - indication cavity

[0094] 222 - scale

[0095] 23 - drive plate

[0096] 24 - pressure sensitive membrane

[0097] 25 - adhesive

[0098] 3 - concentration measuring member

[0099] 31 - body portion

[0100] 32 - adhesive material

[0101] 33 - pH measuring member

[0102] 34 - occult blood measuring member

[0103] 35 - pepsin measurement component;

[0104] 36 - trypsin measurement component;

[0105] 4 - image component;

[0106] 41 - lens;

[0107] 411 - lens base;

[0108] 42 - image sensor;

[0109] 43 - illumination lamp;

[0110] 5 - data transmission assembly;

[0111] 51 - data acquisition processing module;

[0112] 52 - antenna;

[0113] 53 - battery;

[0114] 6 - infrared switch;

[0115] D1 - effective imaging angle boundary;

[0116] D2 - effective viewing angle boundary.

DETAILED DESCRIPTION

[0117] In order to better understand the technical solutions of the present application, the embodiments of the present application are described in detail below in conjunction with the drawings.

[0118] It should be clear that the described embodiments are only some of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of protection of the present application.

[0119] The terms used in the embodiments of the present application are only for the purpose of describing the specific embodiments, and are not intended to limit the present application. The singular forms "a", "an" and "the" used in the embodiments of the present application and the appended claims are also intended to include the plural forms, unless the context clearly indicates otherwise.

[0120] It should be understood that the term "and / or" used herein is only to describe the association relationship of the associated objects, which means that there can be three relationships, for example, A and / or B, which can represent the three cases of A alone, A and B together, and B alone. In addition, the character " / " in this paper generally represents that the front and rear associated objects are a "or" relationship.

[0121] It should be noted that the "upper", "lower", "left", "right" and other directional words described in the embodiments of the present application are described in the angle shown in the drawings, and should not be understood as a limitation on the embodiments of the present application. In addition, in the context, it should also be understood that when referring to an element connected to another element "on" or "under", it can not only be directly connected to another element "on" or "under", but also indirectly connected to another element "on" or "under" through an intermediate element.

[0122] In the field of medical devices, when measuring the pressure of the human digestive tract, a MEMS (Micro-Electro-Mechanical System) pressure sensor is usually used, which is made of traditional microelectronic and micromachining technology. In order to meet the biocompatibility with the human body, the pressure sensor needs to be packaged twice when used to measure the pressure of the human digestive tract. In addition, when measuring the concentration of various parameters of the human digestive tract, a sensor developed by semiconductor technology is usually used.

[0123] Endoscope devices, micro-electromechanical pressure sensors and semiconductor sensors are all used to realize the detection of the human digestive tract. In theory, the above three components can be integrated, but there is no process that can integrate the above three components at present, or the device formed by integrating the above three components has low reliability and high integrated process cost. Based on this, so far there has been no report of a device that can simultaneously detect the image, pressure and concentration information of the digestive tract mucosa, resulting in a complex detection process of the human digestive tract and the need for more detection equipment.

[0124] The medical detection device in the present application can observe the health status of the digestive tract mucosa and obtain the pressure and concentration information of the digestive tract, that is, the medical detection device integrates the endoscope device, the concentration measuring component and the pressure measuring component. At the same time, by changing the structure of the concentration measuring component and the pressure measuring component, the integration process of the above three components can be simplified and the integrated cost can be reduced. The specific structure of the medical detection device is described below.

[0125] The embodiments of the present application provide a medical detection device, such as Figure 1 and Figure 2As shown, the medical detection device comprises a shell 1, a pressure measuring component 2 and a concentration measuring component 3, wherein the shell 1 can further comprise an upper shell 12 and a lower shell 13, and the upper shell 12 and the lower shell 13 are fixedly connected and enclose an inner cavity of the shell 1; the concentration measuring component 3 is installed on the outer wall of the shell 1 and is used to measure the parameters of the external environment of the shell 1. When the medical detection device is used for detecting the digestive tract, it can be used to detect the pH value, occult blood concentration, pepsin concentration and trypsin concentration of the digestive tract. The pressure measuring component 2 is installed on the outer wall of the shell 1, wherein the pressure measuring component 2 is used to measure the pressure of the shell 1 received from the external environment. For example, when the medical detection device is placed in the digestive tract of the human body, the external environment of the shell 1 refers to the digestive tract of the human body, and at this time, the pressure measuring component 2 is used to measure the pressure in the digestive tract of the human body.

[0126] Therefore, the medical detection device in the embodiment of the present application can realize the detection of various parameters (including pH value, occult blood concentration, pepsin concentration and trypsin concentration) in the digestive tract by setting the concentration measuring component 3, thereby improving the accuracy of the detection result of the digestive tract of the medical detection device. At the same time, the medical detection device can measure the pressure in the digestive tract by setting the pressure measuring component 2, thereby further improving the accuracy of the detection result. And the medical detection device can reduce the medical detection procedure and the number of equipment required in the detection process, thereby saving costs.

[0127] Specifically, as shown in Figure 4 and Figure 7 The pressure measuring component 2 comprises a driving part 21, an indicating part 22 and an indicator, wherein the indicating part 22 has an indicating cavity 221 inside, the indicator can flow in the indicating cavity 221, and the indicating part 22 is further provided with a scale 222, when the indicator flows in the indicating cavity 221, it can correspond to different scales. At the same time, when the pressure measuring component 2 is subjected to the pressure of the external environment (such as the pressure of the human digestive tract), the driving part 21 can drive the indicator to flow in the indicating cavity 221, and the scale 222 corresponding to the indicator during the flowing process can represent the pressure received by the pressure measuring component 2.

[0128] In the indicating part 22, after the scale 222 is set, a reference point, i.e. the zero point of the scale 222, is obtained, when the indicator points to the zero point position, it indicates that the pressure received by the pressure measuring component 2 is approximately zero, when the indicator points to a scale 222 greater than zero, it indicates that the pressure measuring component 2 is subjected to the pressure of the external environment (such as the pressure of the human digestive tract), and the greater the scale 222 pointed by the indicator, the greater the external pressure received by the pressure measuring component 2.

[0129] More specifically, as shown in Figures 4 to 6As shown, in the first embodiment, the driving part 21 has a driving cavity 211 which is in communication with the indicating cavity 221, and the indicating agent is in the driving cavity 211, and when the pressure measuring part 2 is subjected to a pressure close to zero, the indicating agent is all in the driving cavity 211, and the indicating agent fills the driving cavity 211, at this time, the indicating agent points to the zero point in the indicating part 22. When the pressure measuring part 2 is subjected to a pressure greater than zero, the pressure can act on the driving part 21, and under the action of the pressure, the driving cavity 211 can be deformed towards the inside, and in the process of deformation, the indicating agent in the driving cavity 211 can be pressed into the indicating cavity 221, so that the indicating agent can point to the scale 222 greater than zero, and the greater the pressure, the more indicating agent enters the indicating cavity 221, and the greater the scale 222.

[0130] Of course, the position of the scale 222 in the indicating part 22 can also be adjusted according to the flow of the indicating agent inside the pressure measuring part 2, in order to ensure that the pressure measuring part 2 has high measurement accuracy, the indicating agent in the inner cavity can at least fill the driving cavity 211.

[0131] On the other hand, by changing the cross-sectional area of the indicating cavity 211, the measurement sensitivity of the pressure measuring part 2 can be adjusted, the smaller the cross-sectional area of the indicating cavity 211, the higher the sensitivity and the higher the accuracy. At the same time, the range of the pressure measuring part 2 can also be adjusted by changing the length of the indicating cavity 211 along the flow direction of the indicating agent (the length of the indicating part 22), the longer the length of the indicating part 22, the greater the range.

[0132] In this embodiment, as shown in Figure 5 and Figure 6 The driving part 21 includes a pressure-sensitive film 24, which surrounds the above-mentioned driving cavity 211, and the pressure-sensitive film 24 can be one or more of polyester film, polyamide film, which can be deformed towards the inside of the driving cavity 211 when subjected to external pressure, and can return to the original state when the pressure disappears, so that the driving part 21 made of the pressure-sensitive film 24 makes the pressure measuring part 2 have high sensitivity and can be measured multiple times.

[0133] Specifically, the above-mentioned driving cavity 211 can be completely surrounded by the pressure-sensitive film 24, as shown in Figure 5 and Figure 6 The driving part 21 can also include a plurality of pressure-sensitive films 24, and each pressure-sensitive film 24 is connected by an adhesive 25, wherein the adhesive 25 can be one or more of acrylate and epoxy.

[0134] More specifically, as shown in Figure 4As shown, the driving part 21 and the indicating part 22 are integrally formed, and the driving part 21 and the indicating part 22 both include the pressure-sensitive membrane 24, so that the pressure-sensitive membrane 24 encloses the driving cavity 211 and the indicating cavity 221. At this time, due to the property of the pressure-sensitive membrane 24, the driving cavity 211 can be deformed after the driving part 21 is stressed, and the indicating cavity 221 can also be deformed after the indicating part 22 is stressed. However, the deformation of the indicating cavity 221 can affect the accuracy of the measurement result.

[0135] To solve the technical problem, in the embodiment, as shown in the figure, Figure 4 the cross-sectional area of the driving cavity 211 is greater than that of the indicating cavity 221, and the cross-sectional area of the driving cavity 211 is 2-10 times or more than that of the indicating cavity 221. When the driving part 21 and the indicating part 22 are stressed, the driving cavity 211 can be deformed, while the deformation of the indicating cavity 221 is very small, so that the pressure measurement component 2 has high sensitivity and measurement accuracy.

[0136] Of course, in order to prevent the indicating cavity 221 from deforming when stressed and affecting the measurement accuracy, the indicating part 22 can also be provided with a structure with high strength and rigidity, which is not easy to deform when stressed. However, in the embodiment, the driving part 21 and the indicating part 22 have the advantages of simple structure and convenient processing. At the same time, when the pressure measurement component 2 is used in medical detection equipment, the pressure-sensitive membrane 24 with small rigidity has less harm to the human body and has high biocompatibility with the human body, so as to improve the safety of the pressure measurement component 2.

[0137] As shown in the embodiment, Figure 7 the pressure measurement component 2 includes the driving part 21, the indicating part 22 and the driving plate 23. The driving part 21 includes the gas cavity 212 and the liquid cavity 213. The gas cavity 212 is used to contain gas (the gas is non-biologically toxic gas, and its pressure is also within the range that the human body can withstand). The liquid cavity 213 is used to contain liquid (such as an indicator), and the gas cavity 212 and the liquid cavity 213 are separated by the driving plate 23. The driving plate 23 can move to adjust the volume of the gas cavity 212 and the liquid cavity 213. The indicating part 22 includes the indicating cavity 221 which communicates with the liquid cavity 213, i.e. the liquid in the liquid cavity 213 can enter the indicating cavity 221, and the liquid in the indicating cavity 221 can also enter the liquid cavity 213. The indicating part 22 is also provided with the scale 222 for indicating the scale.

[0138] When the external pressure on the gas cavity 212 of the pressure measuring component 2 increases, the side wall of the gas cavity 212 can be squeezed, so that the volume of the gas cavity 212 decreases, the pressure inside the gas cavity 212 increases, thereby driving the driving plate 23 to move towards the liquid cavity 213, reducing the volume of the liquid cavity 213, thereby driving the liquid in the liquid cavity 213 into the indicating cavity 221, increasing the scale displayed by the indicating part 22, indicating that the measured pressure increases, and the specific value can be displayed by the scale 222. When the external pressure on the gas cavity 212 of the pressure measuring component 2 decreases (smaller than the pressure of the liquid in the liquid cavity 213 on the gas cavity 212), the liquid in the liquid cavity 213 can drive the driving plate 23 to move towards the gas cavity 212, the volume of the liquid cavity 213 increases, so that the liquid in the indicating cavity 221 enters the liquid cavity 213, thereby reducing the scale displayed by the indicating part 22, indicating that the measured pressure decreases, and the specific value can be displayed by the scale 222. In the above embodiments, the indicator can be one or more of methylene blue, betacyanin, and vitamin B, wherein methylene blue dissolved in water is a blue solution, betacyanin dissolved in water is a red solution, and vitamin B dissolved in water is a yellow solution. Therefore, the above three substances can improve the recognizability of the indicator in the indicating cavity 221. In order to avoid being close to the color inside the human body, methylene blue solution is preferred. At the same time, the scale 222 of the indicating part 22 can be white, so as to be easily distinguished from the indicator.

[0139] Further, the medical detection device can include a plurality of pressure measuring components 2, and the ranges of the pressure measuring components 2 are not completely the same. At this time, the plurality of pressure measuring components 2 with different ranges can meet the measurement of different pressure ranges, and improve the accuracy of the detection result.

[0140] At the same time, when the medical detection device includes a plurality of pressure measuring components 2, it can avoid the situation that a single pressure measuring component 2 fails and cannot measure pressure or the measurement result is inaccurate. The pressure measuring component 2 is attached to the outer surface of the shell 1 by a transparent adhesive material. The transparent adhesive has biocompatibility, and can be, but is not limited to, medical grade UV adhesive, medical instant dry adhesive, or medical adhesive.

[0141] In one possible design, the concentration measuring component 3 in the embodiments of the present application can include one or more of a pH measuring component 33, a latent blood measuring component 34, a pepsin measuring component 35, and a trypsin measuring component 36, wherein the pH measuring component 33 can be used to measure the pH of the external environment (e.g. the digestive tract) of the shell 1, the latent blood measuring component 34 can be used to measure whether there is latent blood in the external environment (e.g. the digestive tract) of the shell 1 and the concentration of the latent blood, the pepsin measuring component 35 can be used to measure the concentration of pepsin in the external environment (e.g. the digestive tract) of the shell 1, and the trypsin measuring component 36 can be used to measure the concentration of trypsin in the external environment (e.g. the digestive tract) of the shell 1.

[0142] Therefore, in the embodiments, the measurement of various parameters of the digestive tract can be achieved by the above-mentioned various concentration measuring components 3, thereby improving the accuracy of the detection results of the medical detection device.

[0143] It should be noted that the medical detection device in the embodiments of the present application does not necessarily include the above-mentioned four concentration measuring components 3, and can only include one or any combination thereof.

[0144] Specifically, as shown in Figure 8 the concentration measuring component 3 can include a body part 31 and an adhesive material 32, wherein the adhesive material 32 is a transparent adhesive material and has biocompatibility, so that the body part 31 of the concentration measuring component 3 can be pasted to the shell 1 of the medical detection device through the adhesive material 32. The adhesive material 32 can be transparent adhesive, and is pasted to the transparent part 11 of the shell 1. The transparent adhesive can be, but is not limited to, medical grade UV adhesive, medical instant adhesive, or medical adhesive.

[0145] More specifically, as shown in Figure 9 the body part 31 of the concentration measuring component 3 and the outer wall of the shell 1 are further connected by a sealing edge adhesive 14, wherein the sealing edge adhesive 14 is arranged at the outer edge of the body part 31, so that the concentration measuring component 3 and the shell 1 are adhered by the sealing edge adhesive 14. The sealing edge adhesive 14 can be, but is not limited to, medical grade UV adhesive, medical instant adhesive, or medical adhesive.

[0146] In the embodiments, when the outer edge of the concentration measuring component 3 and the shell 1 are connected by the sealing edge adhesive 14, the connection reliability between the concentration measuring component 3 and the shell 1 can be further improved, and the risk of the concentration measuring component 3 falling off from the shell 1 during use and installation can be reduced.

[0147] Specifically, the concentration measuring component 3 can include a polyionic gel and a dye, and the dye can change color. The concentration measuring component 3 can be a thin film structure, and can have any shape such as a circular shape, a square shape, a polygonal shape, etc. The specific shape of the concentration measuring component 3 is not limited in the present application.

[0148] In one possible design, the body part 31 of the concentration measuring part 3 comprises a polyion gel and a dye, wherein the dye can change color, the polyion gel is a solid substance formed by polymer cross-linking polymerization, and the dye is filled in the polyion gel, and the dye ions can be kept in the polyion gel due to the strong ion interaction between the polyion gel and the dye ions.

[0149] The polyion gel contains an ion exchange membrane structure, and the ion exchange membrane is a polymer membrane containing ion groups and having selective permeability to ions in a solution. When the concentration measuring part 3 is located in a solution environment (for example, the digestive tract of a human body), the ions (for example, hydrogen ions) of the measured substance in the solution can enter the polyion gel and combine with the dye in the polyion gel to change the color of the dye. In addition, the ions (for example, hydrogen ions) of the measured substance in the solution and the ions (for example, hydrogen ions) of the detected substance in the polyion gel have the same concentration, and when the concentration of the ions (for example, hydrogen ions) of the detected substance in the solution increases, the ions (for example, hydrogen ions) of the detected substance can diffuse into the polyion gel, thereby increasing the concentration of the ions (for example, hydrogen ions) of the measured substance combined with the dye, corresponding to one concentration of the measured substance (for example, the concentration of hydrogen ions, i.e., the pH value of the solution); when the concentration of the ions (for example, hydrogen ions) of the measured substance in the solution decreases, the ions (for example, hydrogen ions) of the measured substance in the polyion gel can diffuse into the solution, thereby reducing the concentration of the ions (for example, hydrogen ions) of the measured substance combined with the dye, corresponding to another concentration of the measured substance (for example, the concentration of hydrogen ions, i.e., the pH value of the solution).

[0150] Therefore, in this embodiment, the dye in the concentration measuring part 3 can combine or separate with the ions (for example, hydrogen ions) of the measured substance to form a dynamic equilibrium, and continuous measurement of the concentration of the measured substance can be achieved.

[0151] Based on this, in this embodiment, the concentration measuring part 3 comprising a polyion gel and a dye can be conveniently integrated (for example, pasted) with a medical detection device (for example, a capsule endoscope), and is compatible with the hardware of the medical detection device after integration, without the need for secondary packaging, and only the relevant software needs to be modified to achieve simultaneous pH measurement during endoscopy, so as to improve the accuracy of detection. At the same time, by adding a polyion gel, and the ions of the detected substance in the solution can penetrate the polyion gel and combine with the dye, and the ions of the detected substance combined with the dye can also penetrate the polyion gel, so that the concentration measuring part 3 can form a dynamic equilibrium with the ions of the detected substance to achieve continuous measurement of the concentration of the detected substance. In addition, the concentration measuring part 3 also helps to realize industrialization and reduce costs.

[0152] In a specific embodiment, when the medical detection device is used to measure the pH value of the digestive tract, the concentration measuring component 3 at least comprises a pH measuring component 33, wherein the body part 31 of the pH measuring component 33 can comprise a polyionic gel and a pH-sensitive dye, wherein the pH-sensitive dye has different colors when the concentration of hydrogen ions in the solution is different.

[0153] In the field of medical devices, when detecting the pH value of the human body, the existing technology mainly realizes it in the following two ways. One is the pH electrode, which is made of materials sensitive to hydrogen ions. By using electrochemical principles, the pH value of the environment to be tested can be directly tested, and the precision is high, such as antimony electrode. The other solution is to determine the pH value of the environment to be tested by color change, which has low precision, such as traditional pH test paper and pH indicator.

[0154] When measuring pH by electrochemical method, the sensor is relatively complex, and the reference electrode and the test electrode need to be packaged together, and at the same time, it needs to ensure that there is an ion channel between it and the test environment. For the conventional use scene, glass electrode, antimony electrode and hydrogen ion sensitive field effect transistor (H + SFET) can meet the application requirements. However, for the measurement of the pH value of the human digestive tract, it is extremely difficult to integrate the above-mentioned pH electrode into the capsule endoscope, which is not easy to realize. In addition, if the antimony electrode is used as the pH electrode, there is also potential biological toxicity.

[0155] The method of measuring pH value by color change has a long history, but this method cannot continuously measure different pH environments, and it is also impossible to integrate it into the capsule endoscope device for continuous pH measurement.

[0156] Based on the above reasons, in the field of medical devices, there is currently no technology that can integrate the endoscope device and the pH measurement sensor, or with the current technology, the device formed after the integration of the endoscope device and the pH measurement sensor has low reliability, and the integrated process cost is high.

[0157] In the embodiment, the medical detection device can obtain the pH information of the digestive tract, that is, the medical detection device integrates the pH measuring component 33. Meanwhile, by changing the structure of the pH measuring component 33, the integration process can be simplified and the integration cost can be reduced. The pH measuring component 33 including the polyion gel and the pH-sensitive dye does not need to use an electrochemical electrode, can be conveniently integrated (for example, pasted) with the medical detection device (for example, a capsule endoscope), is compatible with the hardware of the medical detection device after integration, does not need to be secondarily packaged, and only needs to modify the related software to realize endoscopy while measuring the pH value, so as to improve the detection accuracy. Meanwhile, by additionally arranging the polyion gel, the hydrogen ions in the solution can pass through the polyion gel and combine with the pH-sensitive dye. The hydrogen ions combined with the pH-sensitive dye can also pass through the polyion gel, so that the pH measuring component 33 can form a dynamic balance with the hydrogen ions to realize continuous measurement of the pH value. In addition to being capable of measuring the pH value in the stomach, the pH measuring component 33 can also measure the pH values of organs such as the oral cavity and the intestinal tract. Different colors can be displayed according to different pH values of different organs. In addition, the pH measuring component 33 is also conducive to industrialization and cost reduction.

[0158] Specifically, by changing the amount or type of the pH-sensitive dye in the pH measuring component 33, the range and accuracy of the pH measuring component 33 can be changed. For example, one type of pH measuring component 33 can meet the measurement of pH values of 1, 5, 7 and 8, and another type of pH measuring component 33 can meet the measurement of pH values of 2, 3, 4 and 6. Therefore, when the medical measuring component includes the above two types of pH measuring components 33, the measurement of pH values in the range of 1-8 can be met, and the resolution of 0.5-1 pH value can be met. The difference between the above two types of pH measuring components 33 lies in that the types of the sensitive dyes are different, and the polyion gels can be the same.

[0159] In another specific embodiment, when the medical detection device is used to measure whether there is occult blood in the digestive tract and the concentration of the occult blood, the concentration measuring component 3 at least includes an occult blood measuring component 34. The body part 31 of the occult blood measuring component 34 can include a polyion gel and a methylene blue dye. When the concentration of hemoglobin in the solution is different, the methylene blue dye has different colors.

[0160] In the field of medical devices, there are two mainstream schemes for detecting occult blood in the digestive tract. The first scheme is the occult pearl method, the basic principle of which is to swallow a capsule-shaped object with a fine line. After the capsule-shaped object absorbs gastric juice at the tail, it is pulled out through the fine line. Then, a developing agent is added to the capsule-shaped object soaked with gastric juice, and the color change is observed to determine whether occult blood is produced. The second scheme is to detect the occult blood condition of the digestive tract by detecting the bleeding in the feces through the occult blood test paper.

[0161] The first scheme is only applicable to the detection of occult blood in the upper digestive tract and is a kind of invasive detection, which may cause discomfort such as vomiting. The second scheme is only applicable to the detection of occult blood in the lower digestive tract, especially the detection of colorectal, and is prone to false positive phenomenon due to the influence of hemorrhoids and the like.

[0162] In the embodiment, when the occult blood measuring component 34 including the polyion gel and the methylene blue dye is used, the methylene blue dye ions can be kept in the polyion gel without leakage due to the strong ion interaction between the polyion gel and the methylene blue dye ions. The methylene blue dye is a biological dye and has an oxidizing effect on hemoglobin. During the reaction process, the methylene blue dye is reduced by hemoglobin and changes from blue to colorless. The depth of blue color is different according to the concentration of hemoglobin, and the occult blood condition can be quantitatively detected through the color change.

[0163] In the embodiment, the methylene blue dye is a non-toxic dye, which is blue in the oxidized form and colorless in the reduced form. In the environment with high concentration of hemoglobin, the cells have strong reducing ability under the action of glucose-6-phosphate dehydrogenase, so that the methylene blue dye changes from the blue oxidized form to the colorless or light yellow reduced form. In the environment with low concentration of hemoglobin, the cells in the environment have no reducing ability or weak reducing ability, so that the methylene blue dye is blue or light blue. Therefore, when the methylene blue dye is blue or light blue, it indicates that the hemoglobin in the environment (for example, the digestive tract) is low in concentration, and when the methylene blue dye is colorless or light yellow, it indicates that the hemoglobin in the environment (for example, the digestive tract) is high in concentration.

[0164] In addition, the occult blood measuring component 34 in the embodiment can realize continuous measurement and can measure the occult blood concentration of different organs, for example, the occult blood of the stomach, the intestinal tract and the like.

[0165] Therefore, the medical detection device in the embodiment of the application integrates the occult blood measuring component 34, and at the same time, the structure of the occult blood measuring component 34 can be changed to simplify the integration process and reduce the cost. More importantly, the medical detection device can realize non-invasive detection and has high measurement accuracy.

[0166] In another specific embodiment, when the medical detection device is used to measure the pepsin concentration in the digestive tract, the concentration measuring component 3 at least includes a pepsin measuring component 35, wherein the body part 31 of the pepsin measuring component 35 can include a polyion gel and a bromophenol blue dye, and the bromophenol blue dye has different colors when the pepsin concentration in the solution (for example, the digestive tract) is different.

[0167] The pepsin in human gastric juice has become a biological marker of gastritis, gastric cancer and other diseases. When intestinal epithelial metaplasia, atypical hyperplasia and gastric cancer occur, the secretion of pepsin will decrease. When Helicobacter pylori infection or gastric ulcer, duodenal ulcer and other diseases occur, the pepsin value will increase. At present, a large number of statistical analyses show that the change of serum pepsinogen content is related to gastric diseases, and it is considered that the detection of serum pepsinogen plays an important role in the early diagnosis of gastric cancer.

[0168] At present, the existing technology mainly detects the content of pepsin through three ways. The first way is serum collection for in vitro detection. This method collects the serum of the testee for analysis. However, this method collects samples in vivo for detection in vitro to analyze the specific content of pepsin. Therefore, the measured pepsin is single detection, which has limitations for real-time monitoring of the content of pepsin in gastric juice. In addition, pepsin only plays a role in an acidic environment and loses activity when pH>6. In the in vitro environment, the test results are not accurate due to the influence of the environment. The second way is to rely on gastroscopy for diagnosis. However, gastroscopy is painful, expensive and limited by the level of doctors, and patients have low acceptance. The third way is the pepsin chemiluminescence immunoassay kit detection method. The pepsin chemiluminescence immunoassay kit is used. The kit includes pepsin antigen calibrator, sample collection liquid, sample diluent, pepsin antibody coated microplate, pepsin antibody label, chemiluminescence substrate liquid and concentrated washing liquid. The kit can detect the content of pepsin in gastric juice, esophageal contents and throat secretions. Whether the presence of gastroesophageal reflux can be determined according to whether pepsin can be detected. The effect of gastric lesion treatment and the change of disease condition can be determined according to the content of pepsin. Although this method can detect pepsin, the process is complex, the requirements for operators and detection equipment are high, and the cost is also high.

[0169] In the embodiment of the present application, when the pepsin measuring component 35 including the polyionic gel and the bromophenol blue dye is used, the polyionic liquid gel has strong ionic interaction with the bromophenol blue dye ions, so that the bromophenol blue dye ions can be kept in the gel without leakage. The bromophenol blue dye is a biological dye. Under different pH conditions, the bromophenol blue dye is combined with pepsin through non-covalent bonds. The hydrophobic core of pepsin is combined with the non-polar group of bromophenol blue dye. The volume of the aggregate after combination is larger than the volume of bromophenol blue dye itself. The molar absorption coefficient after combination changes, the light scattering signal changes, and different colors are displayed. The signal intensity is proportional to the number of particles per unit volume, that is, the concentration of pepsin. Therefore, the detection of the concentration of pepsin can be realized. During the detection process, the bromophenol blue dye in the pepsin measuring component 35 shows different colors for different concentrations of pepsin. The concentration can be quantitatively detected by color change.

[0170] In addition, since pepsin can only exist in an acidic environment, and will lose activity and denature in a neutral or alkaline environment, pepsin only exists in the stomach. Based on this, the pepsin measuring component 35 can only be used to measure the concentration of pepsin in the stomach, and cannot be used in other organs (because pepsin is inactivated in other organs). During detection, pepsin in the stomach combines with bromophenol blue dye, causing the molar absorption coefficient to change, the light scattering signal to change, and then displaying a color, and the color is in a certain proportional relationship with the concentration of pepsin, thereby achieving detection of the corresponding protein. The pepsin measuring component 35 has different color development changes in a low concentration to high concentration range in an acidic detection environment, and has a certain continuous detection function; but it does not have a continuous detection characteristic when the solution environment changes (for example, after the stomach to the duodenum).

[0171] Therefore, the medical detection device in the embodiments of the present application integrates the pepsin measuring component 35, and by changing the structure of the pepsin measuring component 35, the integration process can be simplified and the cost can be reduced. More importantly, the medical detection device can achieve non-invasive detection, and has high measurement accuracy.

[0172] In another specific embodiment, when the medical detection device is used to measure the trypsin concentration of the digestive tract, the concentration measuring component 3 at least includes a trypsin measuring component 36, wherein the body part 31 of the trypsin measuring component 36 can include polyionic gel and bromocresol purple dye, and the bromocresol purple dye has different colors when the trypsin concentration in the solution (for example, the digestive tract) is different.

[0173] In the embodiments of the present application, the trypsin measuring component 36 including polyionic gel and bromocresol purple dye has strong ionic interaction between the polyionic liquid gel and the bromocresol purple dye ions when in use, so that the bromocresol purple dye ions can be kept in the gel without leakage. The bromocresol purple dye is a biological dye, and under different pH conditions, the bromocresol purple dye is combined with trypsin through a non-covalent bond. The hydrophobic core of trypsin is combined with the non-polar group of bromocresol purple dye, and the volume of the aggregate after combination is larger than the volume of bromocresol purple dye itself, so that the molar absorption coefficient after combination changes, the light scattering signal changes, and then different colors are displayed. The signal intensity is proportional to the number of particles in a unit volume, that is, the concentration of trypsin, so the detection of the concentration of trypsin can be realized. During the detection process, the bromocresol purple dye in the trypsin measuring component 36 shows different colors for different concentrations of trypsin, and the concentration can be quantitatively detected through color change.

[0174] In addition, since trypsin can only exist in weak alkaline environment and will be denatured in acidic environment, trypsin exists in pancreas and can flow into duodenum with pancreatic juice, based on which the trypsin measuring component 36 can only be used to measure the trypsin concentration in pancreas and duodenum and cannot be used to measure the trypsin concentration in other organs (because the trypsin in other organs is inactivated). During detection, trypsin combines with bromocresol purple dye, so that the molar absorption coefficient changes, the light scattering signal changes, color is displayed, and the color is in a certain proportional relationship with the concentration of trypsin, so as to realize detection of the corresponding protein. The trypsin measuring component 36 has different color changes in a low concentration to high concentration range in a weak alkaline detection environment, and has a certain continuous detection function; but it does not have the continuous detection characteristic when the solution environment changes (for example, from the duodenum to the jejunum).

[0175] Therefore, the medical detection device in the embodiment of the present application integrates the trypsin measuring component 36, and by changing the structure of the trypsin measuring component 36, the integration process can be simplified and the cost can be reduced. More importantly, the medical detection device can realize non-invasive detection and has high measurement accuracy.

[0176] In a specific embodiment, the medical detection device can include a plurality of concentration measuring components 3, and the ranges of the concentration measuring components 3 are not completely the same, and / or the resolutions of the concentration measuring components 3 are not completely the same. By combining the plurality of concentration measuring components 3, the measurement of the concentration of various to-be-measured parameters can be met, and the measurement accuracy and measurement range are improved. Alternatively, the medical detection device can include a plurality of concentration measuring components 3 and a pressure measuring component 2. At the same time, when a plurality of concentration measuring components 3 are included, it can also avoid the situation that a single concentration measuring component 3 fails, resulting in that the to-be-measured parameter cannot be measured or the measurement result is inaccurate. For example, the medical detection device can include a plurality of pH measuring components 33, and the ranges of the pH measuring components 33 are not completely the same, and / or the resolutions of the pH measuring components 33 are not completely the same. By combining the plurality of pH measuring components 33, the measurement of various pH values can be met, the measurement accuracy and measurement range are improved, and the situation that a single pH measuring component 33 fails, resulting in that the pH value information cannot be measured or the measurement result is inaccurate can be avoided.

[0177] In addition, the plurality of concentration measuring components 3 can be the same type of concentration measuring component 3 or different types of concentration measuring component 3, that is, a combination of a plurality of concentration measuring components 3. For example, as shown in FIG. 1, the medical detection device can include a plurality of pH measuring components 33 and a plurality of trypsin measuring components 36. Figure 10In the illustrated embodiment, the medical testing device includes a pressure measuring component 2, a pH measuring component 33, a occult blood measuring component 34, a pepsin measuring component 35, and a trypsin measuring component 36, thereby enabling the device to measure the pH value, occult blood concentration, pepsin concentration, and trypsin concentration in the digestive tract. Furthermore, one or more of the aforementioned pH measuring component 33, occult blood measuring component 34, pepsin measuring component 35, and trypsin measuring component 36 can be included to improve measurement accuracy. The shape of each concentration measuring component 3 can be circular, and the shape of the pressure measuring component 2 can be rectangular.

[0178] like Figure 11 In the illustrated embodiment, the medical testing device includes a pressure measuring component 2, a pepsin measuring component 35, and a trypsin measuring component 36, thereby enabling the device to measure pressure, pepsin concentration, and trypsin concentration in the digestive tract. Furthermore, one or more of the pressure measuring component 2, pepsin measuring component 35, and trypsin measuring component 36 can be included to improve measurement accuracy. The shape of each measuring component can be rectangular.

[0179] like Figure 12 In the illustrated embodiment, the medical testing device includes a pressure measuring component 2, a pH measuring component 33, and a occult blood measuring component 34, enabling the device to measure pressure, pH value, and occult blood concentration. Furthermore, the pressure measuring component 2, pH measuring component 33, and occult blood measuring component 34 can each include one or more components to improve measurement accuracy. The shapes of the concentration measuring components can be circular, and the shape of the pressure measuring component 2 can be rectangular.

[0180] In the above embodiments, as Figure 12 As shown, in this medical testing device, at least a portion of the housing 1 is a transparent portion 11, which is made of a biocompatible transparent material, so that the environment outside the housing 1 can be observed from the inside of the housing 1 through the transparent portion 11.

[0181] Meanwhile, the medical testing device also includes an imaging component 4, such as Figures 1 to 3 As shown, the imaging component 4 is located inside the housing 1 and specifically includes a lens 41, an image sensor 42, and an illumination lamp 43. The lens 41 can receive light from the external environment (e.g., the human digestive tract) through the transparent portion 11 of the housing 1. The image sensor 42 converts the light signal received by the lens 41 into an electrical signal. The illumination lamp 43 is used for illumination and can specifically be an LED lamp, and the illumination lamp 43 includes an LED structural component 431. Therefore, the imaging component 4 can capture and observe images of the external environment of the housing 1 through the principle of optical imaging. Based on this, the medical testing device in this embodiment can be an endoscope.

[0182] Further, as shown in Figure 2 and Figure 3 , the medical detection device further comprises a data transmission assembly 5 located in the inner cavity of the shell 1, specifically comprising a data acquisition and processing module 51, an antenna 52 and a battery 53, wherein the battery 53 supplies power to each component in the image component 4 and the data transmission assembly 5, the data acquisition and processing module 51 is electrically connected or signal connected with the image component 4, so as to identify and process the information in the image component 4, and at the same time, the antenna 52 is used to transmit the obtained information to an external receiving device.

[0183] Specifically, the medical detection device can be a capsule endoscope. During processing, first, the circuit board of the capsule endoscope is assembled and connected with the image component 4 and the data transmission assembly 5. When each component is connected, it is mainly bonded by UV glue, forming a capsule core with a photographing function. Then, the capsule core is installed into the shell 1. First, the capsule core is installed into the lower shell 13, then the upper shell 12 is installed, and the LED structure 431 is clamped between the upper shell 12 and the lower shell 13, so that the position of the LED structure 431 in the capsule is fixed, and then the capsule core is fixed in the shell 1, and the assembly of the capsule endoscope is completed.

[0184] Therefore, when the medical detection device described above is built into each part of the human body, the pressure measuring component 2 can display different scales according to different pressures, so as to quantitatively detect the pressure; the concentration measuring component 3 can display different colors according to different concentrations of the to-be-measured parameters, and the concentration of the to-be-measured parameters can be quantitatively detected through color change, and the scale of the pressure measuring component 2 and the color change of the concentration measuring component 3 can be judged through the picture obtained by the lens 41 of the image component 4, the scale information and the color information are sent to the external receiving device through the data transmission assembly 5 and can be displayed in real time, so as to facilitate detection. At the same time, the medical detection device can also take and observe the picture of the external environment of the medical detection device through the lens 41 of the image component 4, and the picture information can be sent to the external receiving device through the data transmission assembly 5 and can be displayed in real time, so as to judge the health status of the part.

[0185] The medical detection device in the embodiment of the present application can observe the health status of the digestive tract mucosa through the image component 4 and the data transmission assembly 5, and can measure the pressure in the digestive tract and the concentration of the to-be-measured parameters through the pressure measuring component 2 and the concentration measuring component 3, that is, the medical detection device integrates the endoscope device, the pressure measuring component 2 and the concentration measuring component 3. At the same time, by changing the structure and type of the concentration measuring component 3, the process of integrating the above three components can be simplified, and the integration cost can be reduced.

[0186] Specifically, as shown in Figure 3As shown, lens 41 is mounted inside the cavity of housing 1, and lens 41 has an effective imaging angle α1. Furthermore, the transparent portion 11 of housing 1 can cover the space containing the effective imaging angle α1; therefore, the field of view of lens 41 is not obstructed. Meanwhile, as... Figure 3 As shown, the image sensor 42 has a display image angle α2, and the transparent part 11 of the housing 1 can also cover the space where the display image angle α2 is located. Therefore, the imaging area of ​​the image sensor 42 is not obstructed.

[0187] Simultaneously, after the lens 41 and image sensor 42 are installed, α1 > α2. That is, although the lens 41 can capture images within the range corresponding to α1, and the range corresponding to α1 has an effective imaging angle boundary D1, the range that the image sensor 42 can display is the range corresponding to α2, and the range corresponding to α2 has a display image angle boundary D2. For example, the aforementioned effective imaging angle α1 can be 140°, and the display image angle α2 can be 135°.

[0188] Based on this, in the first specific embodiment, such as Figure 14 As shown, the pressure measuring component 2 and / or concentration measuring component 3 are mounted on the transparent portion 11 and located in the space between the effective imaging angle α1 and the display image angle α2. That is, the pressure measuring component 2 and / or concentration measuring component 3 are located between the effective imaging angle boundary D1 and the display image angle boundary D2. Multiple pressure measuring components 2 and concentration measuring components 3 can be included between the effective imaging angle boundary D1 and the display image angle boundary D2. These multiple pressure measuring components 2 and multiple concentration measuring components 3 can be of the same type or different types, such as... Figure 14 In the embodiment shown, there is a pressure measuring component 2, a pH measuring component 33, and a pepsin measuring component 35 between the effective imaging angle boundary D1 and the display image angle boundary D2, and each of the above measuring components can be an arc-shaped structure, etc.

[0189] At this time, the pressure measuring component 2 and the concentration measuring component 3 cannot be observed within the observation area of ​​the image sensor 42. However, the concentration measuring component 3 is located within the imaging range of the lens 41. Therefore, the lens 41 and the data transmission component 5 can read the color information of the concentration measuring component 3 and transmit the scale information and color information to the external receiving device via the antenna 52. The external receiving device then displays the scale information and color information and obtains the pressure value and the concentration value of the measured parameter based on the color information. Since the pressure measuring component 2 and the concentration measuring component 3 do not occupy the imaging area of ​​the image sensor 42, a complete image of the digestive tract mucosa can be observed. This image can be transmitted to the external receiving device via the antenna 52 and displayed on the external receiving device to observe the health status of the digestive tract.

[0190] In another embodiment, as shown in Figure 15 In this embodiment, the pressure measuring component 2 and / or the concentration measuring component 3 are installed on the transparent part 11 and located in the space occupied by the display image angle a2, i.e. the pressure measuring component 2 and / or the concentration measuring component 3 are located inside the display image angle boundary D2 and close to the display image angle boundary D2, so that the pressure measuring component 2 and / or the concentration measuring component 3 can be prevented from occupying the middle position of the display image range and reducing the obstruction of the image by the pressure measuring component 2 and / or the concentration measuring component 3. At this time, the pressure measuring component 2 and / or the concentration measuring component 3 are located in the imaging area of the image sensor 42, and the image sensor 42 transmits the scale information of the pressure measuring component 2 and / or the color information of the concentration measuring component 3 to the external receiving device, so that the user can observe the scale of the pressure measuring component 2 and the concentration measuring component 3 displayed by color, and the scale information and the color information can be transmitted to the external receiving device through the antenna 52, so that the concentration of the to-be-measured parameter can be displayed on the external receiving device. Therefore, the medical detection device in this embodiment can collect the concentration of the to-be-measured parameter of the digestive tract while observing the mucosa of the digestive tract.

[0191] One or more concentration measuring components 3 and one or more pressure measuring components 2 can be arranged inside the display image angle boundary D2 of the medical detection device, and the plurality of pressure measuring components 2 and the plurality of concentration measuring components 3 can be of the same type or different types, as shown in Figure 15 In the embodiment shown in

[0192] In another specific embodiment, the pressure measuring component 2 and / or the concentration measuring component 3 are installed on the transparent part 11 and located in the space occupied by the display image angle a2, i.e. the pressure measuring component 2 and / or the concentration measuring component 3 are located inside the display image angle boundary D2, and the pressure measuring component 2 and / or the concentration measuring component 3 can be specifically located in the middle of the space occupied by the display image angle a2.

[0193] At this time, the pressure measuring component 2 and / or the concentration measuring component 3 are located in the imaging area of the image sensor 42, and the image sensor 42 transmits the scale of the pressure measuring component 2 and the color information of the concentration measuring component 3 to the external receiving device, so that the user can observe the scale information and the color information through the pressure measuring component 2 and the concentration measuring component 3, and the scale information and the color information can be transmitted to the external receiving device through the antenna 52, so that the pressure and the concentration of the to-be-measured parameter are displayed on the external receiving device. Therefore, the medical detection device in the embodiment can collect the pressure of the digestive tract and the concentration of the to-be-measured parameter while observing the mucosa of the digestive tract. At the same time, when the pressure measuring component 2 and / or the concentration measuring component 3 are located in the middle of the space occupied by the display image angle α2, the user can observe the pressure measuring component 2 and / or the concentration measuring component 3 more conveniently, and the occlusion is reduced, so that the pressure of the digestive tract and the concentration of the to-be-measured parameter can be obtained more accurately.

[0194] The medical detection device can be provided with one or more concentration measuring components 3, and the plurality of concentration measuring components 3 can be of the same type or different types, such as Figure 16 In the embodiment shown, the display image angle boundary D2 and the effective imaging angle boundary D1 are provided with a plurality of pressure measuring components 2, pepsin measuring components 35 and trypsin measuring components 36, and each pepsin measuring component 35 and trypsin measuring component 36 is located in a corner of the field of view. The pH measuring component 33 is located in the display image angle boundary D2, and the pH measuring component 33 is located in the middle of the space occupied by the display image angle α2. Each of the above-mentioned concentration measuring components can be of a circular structure, and the pressure measuring component 2 is of an arc structure.

[0195] At the same time, as shown in Figure 16 The medical detection device can further include an infrared switch 6, which can start the pressure measuring component 2 and / or the concentration measuring component 3, so that the pressure measuring component 2 and / or the concentration measuring component 3 of the medical detection device can start to work.

[0196] As shown in the embodiment shown in Figures 14 to 16 The image angle boundary D2 of the camera 41 of the image component 4 and the effective imaging angle boundary D1 can both be circular, and concentric. In the embodiment shown in Figure 17 The effective imaging angle boundary D1 of the camera 41 of the image component 4 can be square, and the image angle boundary D2 can be circular. At this time, when the pressure measuring component 2 and / or the concentration measuring component 3 are located between the image angle boundary D2 and the effective imaging angle boundary D1, they can be located in the four corners of the effective imaging angle boundary D1.

[0197] In one specific embodiment, the pressure measuring component 2 and the concentration measuring component 3 are arranged on the outer wall of the housing 1 in a partitioned or alternating manner. The partitioned arrangement divides the outer wall of the housing 1 into several regions, with the pressure measuring component 2 and the concentration measuring component 3 positioned in different regions. For example, using the infrared switch 6 as a reference, the transparent portion 11 is rotated clockwise at 90 degrees... 0 To divide the interval into four sub-sections, the pressure measuring component 2 and the concentration measuring component 3 are located in different sub-sections; for example... Figure 15 Divide the transparent portion 11 into

[45] sections, averaging them clockwise and using the infrared switch 6 as a reference. 0 -45 0 ]、[45 0 135 0 ]、[135 0 225 0 ] and [225 0 315 0 After the four sub-parts of the shell 1, one sub-part does not have a measuring component, while the other three sub-parts are respectively equipped with a pressure measuring component 2, a trypsin measuring component 36, and a occult blood measuring component 34. The partitioning arrangement divides the outer wall of the shell 1 into several regions, each region being used to simultaneously house a pressure measuring component 2 and a concentration measuring component 3. There can be one or more pressure measuring components 2 and concentration measuring components 3. For example, using the infrared switch 6 as a reference, and calculating clockwise, the transparent part 11 is positioned at 135 degrees... 0 and -45 0 The structure is divided into two sub-sections along a diagonal, with each sub-section equipped with a pressure measuring component 2 and a concentration measuring component 3; for example... Figure 14 Divide the transparent part 11 clockwise into [-45] based on the infrared switch 6. 0 135 0 ] and [135 0 315 0 After the two sub-parts of ], [-45 0 135 0 A pepsin measuring component 35 and a pressure measuring component 2 are placed in the interval,

[135] 0 315 0 A pH measuring component 33 and a pressure measuring component 2 are placed in the space. This alternating arrangement can maximize the detection results and optimize detection when the solution (e.g., gastrointestinal fluid) is small and only part of the shell 1 is immersed in the solution.

[0198] On the other hand, in this medical testing equipment, such as Figures 10 to 12In the embodiment shown, the imaging component 4 comprises a lens 41 for taking pictures of the digestive tract, obtaining scale information and / or color information of the pressure measuring component 2 and / or the concentration measuring component 3. In this embodiment, the lens 41 can obtain the imaging image of the pressure measuring component 2 and / or the concentration measuring component 3, which is transmitted to an external receiving device via the data transmission assembly 5 together with the picture of the digestive tract, and the external receiving device can identify the pressure value and the concentration of the corresponding parameter to be detected according to the imaging image of the pressure measuring component 2 and / or the concentration measuring component 3 and display it.

[0199] Of course, as Figure 13 shown, the medical detection device can also comprise two imaging components 4, specifically, the housing 1 comprises a first end portion and a second end portion (the upper shell 12 and the lower shell 13) arranged oppositely in the axial direction, and the first end portion and the second end portion can both be provided with a transparent portion 11, and the two imaging components 4 are arranged corresponding to the two transparent portions 11 respectively, wherein the medical detection device can be a double-lens capsule endoscope.

[0200] Specifically, the above-mentioned pressure measuring component 2 and / or concentration measuring component 3 can be all mounted on the outer wall of the first end portion, or can be all mounted on the outer wall of the second end portion, at this time, one imaging component 4 of the medical detection device is used to measure the concentration of the parameter to be measured, and the other is used to observe and take pictures.

[0201] Or, in the medical detection device, the outer wall of the first end portion of the housing 1 is provided with a first measuring component, and the outer wall of the second end portion is provided with a second measuring component, the first end portion can be provided with one or more first measuring components, and the second end portion can be provided with one or more second measuring components, and the types of the first measuring component and the second measuring component can be the same or different (i.e. can be a concentration measuring component, or can be a pressure measuring component), and the ranges can be the same or different, when the ranges are different, the medical detection device can simultaneously satisfy the detection of different concentration ranges and the detection of pressure.

[0202] As Figure 13In the embodiment shown, the first end and the second end of the shell 1 are provided with a camera 41, and the camera 41 is located in the transparent part 11 of the first end and the second end. Meanwhile, the first end can be provided with a pressure measuring component 2, a pH measuring component 33 and a pepsin measuring component 35, and the second end can be provided with a pressure measuring component 2, a occult blood measuring component 34 and a trypsin measuring component 36. At this time, the first end of the medical detection device can be used to not only take pictures of the digestive tract, but also measure the pressure, pH value and pepsin concentration in the digestive tract. The second end of the medical detection device can be used to not only take pictures of the digestive tract, but also measure the pressure, occult blood concentration and trypsin concentration in the digestive tract.

[0203] It should be noted that the medical detection device described above can be a capsule endoscope, and of course, it can also be other medical detection devices, such as electronic endoscopes and other image measuring devices.

[0204] In a specific embodiment, when the medical detection device is a capsule endoscope device, it includes a capsule endoscope and at least one pressure measuring component 2 and at least one concentration measuring component 3 attached to the surface of the transparent part 11 of the capsule shell 1. The concentration measuring component 3 can have a ring structure, and the inner and outer diameters can be 5 mm and 6 mm respectively, and the thickness can be 40 um. Of course, the size and thickness can also be other values, and the body part 31 of the concentration measuring component 3 is attached to the outer surface of the transparent part 11 by medical UV glue (glue material 32). The concentration measuring component 3 can be between the effective imaging angle α1 and the display image angle α2, and does not affect the normal user interface image display. The measurement results of the concentration measuring component 3 can be observed by an external receiving device. Meanwhile, the pressure measuring component 2 can have a rectangular structure, and the thickness of the pressure measuring component 2 is 150 um, the length is 5 mm, and the width is 1.5 mm. The pressure-sensitive film 24 is a 50 um thick polyester film, the length of the indicating cavity 221 is 50 um, and the adhesive 25 is an acrylic adhesive. The driving part 21 is a circle with a diameter of 3 mm, and 20 mg / L concentration of methylene blue solution is filled as an indicator. Through in vitro calibration experiments, the pressure measuring component 2 can meet the pressure measurement of 0-30 kpa in the digestive tract, and the sensitivity can reach 6 kpa.

[0205] The above only describes the preferred embodiments of the present application and is not intended to limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the scope of protection of the present application.

Claims

1. Medical testing equipment, including: case; A pressure measuring component is installed on the outer wall of the housing and is used to measure the pressure of the external environment of the housing; A concentration measuring component is installed on the outer wall of the housing and is used to measure the concentration of the parameter to be measured in the external environment of the housing; The housing includes a transparent portion, and the medical testing device further includes an imaging component located within the cavity of the housing, which is able to observe the external environment of the housing through the transparent portion. The medical testing equipment also includes a data transmission component, and the imaging component includes a lens and an image sensor, the image sensor being electrically connected to the data transmission component; The lens is installed in the inner cavity of the housing, and the lens has an effective imaging angle α1. The transparent part can cover the space where the effective imaging angle α1 is located. The image sensor has a display image angle α2, and the transparent part can cover the space where the display image angle α2 is located, and α1 > α2; The concentration measuring component and / or the pressure measuring component are mounted on the outer wall of the housing and are located in the space between the effective imaging angle α1 and the display image angle α2; The data transmission component is capable of reading data from the concentration measuring component and / or the pressure measuring component.

2. The medical testing equipment according to claim 1, characterized in that, The pressure measuring component includes a drive unit, an indicator unit, and an indicator; The indicator has an indicator cavity and is provided with a scale. When the indicator flows in the indicator cavity, it can correspond to different scales. When under pressure, the drive unit can drive the indicator to flow within the indicator cavity.

3. The medical testing equipment according to claim 2, characterized in that, The driving unit has a driving cavity communicating with the indicating cavity, and the indicator is contained within the driving cavity; When the drive unit is pressed, the drive cavity can deform and press the indicator inside the drive cavity into the indicator cavity.

4. The medical testing equipment according to claim 3, characterized in that, The driving unit includes a pressure-sensitive membrane, which surrounds the driving cavity; When subjected to pressure, the pressure-sensitive membrane can deform toward the inside of the driving cavity; when the pressure is removed, the pressure-sensitive membrane can return to its original state.

5. The medical testing equipment according to claim 3, characterized in that, The driving part and the indicating part are integrally formed, and both the driving part and the indicating part include a pressure-sensitive film, which surrounds the driving cavity and the indicating cavity; The cross-sectional area of ​​the driving cavity is larger than the cross-sectional area of ​​the indicating cavity.

6. The medical testing equipment according to claim 2, characterized in that, The drive unit includes a gas chamber and a liquid chamber, which are separated by a drive plate. The volume of the gas chamber and the liquid chamber is adjusted by moving the drive plate. The liquid chamber contains the indicator, and the indicator in the liquid chamber can enter the indicator chamber, and the indicator in the indicator chamber can also enter the liquid chamber.

7. The medical testing equipment according to any one of claims 2 to 6, characterized in that, The indicator is one or more of methylene blue, betaine, and vitamin B.

8. The medical testing equipment according to any one of claims 1 to 6, characterized in that, The concentration measuring component includes a polyion gel and a dye, wherein the dye is filled in the polyion gel; The dye can change color when the concentration of the parameter to be measured is different.

9. The medical testing equipment according to claim 8, characterized in that, The concentration measuring component includes one or more of the following: pH measuring component, occult blood measuring component, pepsin measuring component, and trypsin measuring component.

10. The medical testing equipment according to claim 9, characterized in that, The dye in the pH measuring component is a pH-sensitive dye, which can change color in environments with different pH values.

11. The medical testing equipment according to claim 10, characterized in that, Hydrogen ions in the external environment of the housing can enter the pH measuring component through the polyion gel, and hydrogen ions in the pH measuring component can enter the external environment of the housing through the polyion gel. The pH-sensitive dye can bind to or separate from hydrogen ions to form a dynamic equilibrium.

12. The medical testing equipment according to claim 9, characterized in that, The dye in the occult blood measuring component includes methylene blue dye, which can change color in environments with different occult blood concentrations.

13. The medical testing equipment according to claim 12, characterized in that, Hemoglobin in the external environment of the shell can bind to and react with the polyionogel and methylene blue dye in the occult blood measuring component; Under the influence of hemoglobin, the methylene blue dye can display color through an oxidation-reduction reaction, and the color displayed by the methylene blue dye varies depending on the concentration of hemoglobin.

14. The medical testing equipment according to claim 9, characterized in that, The dye in the pepsin measuring component includes bromophenol blue dye, which changes color in environments with different pepsin concentrations.

15. The medical testing equipment according to claim 14, characterized in that, The pepsin in the external environment of the housing can bind to the polyionogel and the bromophenol blue dye in the pepsin measuring component; The light scattering signal of the bromophenol blue dye changes after binding, showing different colors, and the color of the bromophenol blue dye is different when the concentration of pepsin is different.

16. The medical testing equipment according to claim 9, characterized in that, The dye in the trypsin measuring component includes bromocresol purple dye, which can change color in environments with different trypsin concentrations.

17. The medical testing equipment according to claim 16, characterized in that, The trypsin in the external environment of the shell can bind to the polyionogel and the bromocresol purple dye in the trypsin measuring component; The volume of the bromocresol purple dye changes after binding, and its light scattering signal changes, resulting in different colors. Furthermore, the color of the bromocresol purple dye varies depending on the concentration of trypsin.

18. The medical testing equipment according to claim 1, characterized in that, The pressure measuring components and concentration measuring components are arranged in a partitioned or alternating manner on the outer wall of the housing.

19. The medical testing equipment according to any one of claims 1 to 6, characterized in that, The housing includes a first end and a second end disposed opposite to each other along the axial direction, and both the first end and the second end include the transparent portion; The medical testing device includes two imaging components, each of which is respectively disposed corresponding to one of the two transparent portions; Of the concentration measuring component and the pressure measuring component, one is installed on the outer wall of the first end, and the other is installed on the outer wall of the second end; or... Both the concentration measuring component and the pressure measuring component are mounted on the outer wall of the first end or the outer wall of the second end; or... The outer wall of the first end is equipped with a first concentration measuring component and a first pressure measuring component, and the outer wall of the second end is equipped with a second concentration measuring component and a second pressure measuring component. The first concentration measuring component and the second concentration measuring component have different measurement ranges, and the first pressure measuring component and the second pressure measuring component have different measurement ranges.

20. The medical testing equipment according to any one of claims 1 to 6, characterized in that, The medical testing equipment includes multiple of the aforementioned measuring components; The measuring ranges of each of the measuring components are not exactly the same, and / or the resolutions of each of the measuring components are not exactly the same; The lens is connected to the image sensor by a mechanical structure and / or glue. The lens is connected to the data transmission component by mechanical structure and / or glue.

Images