Medical testing equipment and measuring component of medical testing equipment

Abstract

The present application relates to a medical testing device and a measuring component of the medical testing device. The medical testing device comprises: a housing; and a measuring component mounted on the outer wall of the housing and configured to measure the concentration of a parameter to be measured in an environment external to the housing. Therefore, the medical testing device in the embodiments of the present application, by providing the measuring component, is capable of detecting various parameters within the digestive tract (including pH, occult blood concentration, pepsin concentration, and trypsin concentration, etc.), thereby improving the accuracy of the digestive tract detection results of the medical testing device and providing the medical testing device with multiple functions, thereby enhancing its practicality.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a medical detection device and a measuring component of the medical detection device. Background Art

[0002] As the pace of life accelerates, people's living pressures gradually increase. Coupled with changes in dietary structure, digestive tract diseases have become a serious type of disease that seriously affects people's quality of life. The diagnosis and treatment of digestive tract diseases are based on accurate examination of the physiological parameters of the digestive tract and the condition of the mucosa.

[0003] Currently, endoscopes are commonly used to visually observe the digestive tract mucosa. However, due to limitations in technical integration, commercially available endoscopes can only provide visual observation of the digestive tract mucosa and are unable to obtain other useful information within the digestive tract. Therefore, existing endoscopes are limited in functionality and are unable to accurately examine the digestive tract. Summary of the Invention

[0004] The present application provides a medical detection device and a measuring component of the medical detection device, and the detection accuracy of the medical detection device is high.

[0005] A first aspect of an embodiment of the present application provides a medical detection device, comprising:

[0006] case;

[0007] The measuring component is installed on the outer wall of the shell and is used to measure the concentration of the parameter to be measured in the environment outside the shell.

[0008] In one possible design, the measuring component includes a polyion gel and a dye, and the dye is filled in the polyion gel;

[0009] The dye is capable of changing color when the concentration of the parameter to be measured is different.

[0010] In a possible design, the measuring component includes one or more of a pH measuring component, an occult blood measuring component, a pepsin measuring component, and a trypsin measuring component.

[0011] In a possible design, the dye of the pH measuring component is a pH-sensitive dye, which can change color in environments with different pH values.

[0012] In one possible design, hydrogen ions in the environment outside the housing can enter the pH measuring component through the polyion gel, and hydrogen ions in the pH measuring component can enter the environment outside the housing through the polyion gel;

[0013] The pH sensitive dye can bind to or dissociate from hydrogen ions to form a dynamic equilibrium.

[0014] In a possible design, the dye of the occult blood measuring component includes methylene blue dye, and the methylene blue dye can change color in an environment with different occult blood concentrations.

[0015] In one possible design, hemoglobin in the environment outside the housing can bind to and react with the polyion gel and the methylene blue dye in the occult blood measurement component;

[0016] Under the action of hemoglobin, the methylene blue dye can show color through redox reaction, and the color shown by the methylene blue dye is different when the concentration of the hemoglobin is different.

[0017] In a possible design, the dye of the pepsin measuring component includes bromophenol blue dye, which can change color in an environment with different pepsin concentrations.

[0018] In a possible design, pepsin in the external environment of the housing can bind to the polyion gel and bromophenol blue dye in the pepsin measuring component;

[0019] The light scattering signal of the bound bromophenol blue dye changes, showing different colors, and the color of the bromophenol blue dye is different when the concentration of pepsin is different.

[0020] In a possible design, the dye of the trypsin measuring component includes bromocresol purple dye, and the bromocresol purple dye can change color in an environment with different trypsin concentrations.

[0021] In a possible design, trypsin in the external environment of the housing can bind to the polyion gel and bromocresol purple dye in the trypsin measuring component;

[0022] After binding, the volume of the bromocresol purple dye changes, and its light scattering signal changes, showing different colors. The color of the bromocresol purple dye varies depending on the concentration of trypsin. In one possible design, the arrangement of the measuring components on the outer wall of the housing is a partitioned arrangement or an alternating arrangement.

[0023] In one possible design, the medical detection device includes a plurality of the measurement components;

[0024] The measuring ranges of the various measuring components are not completely the same, and / or the resolutions of the various measuring components are not completely the same.

[0025] In one possible design, the housing includes a transparent portion;

[0026] The medical detection device further includes an imaging component, which is located in the inner cavity of the shell and can observe the environment outside the shell through the transparent portion.

[0027] In a possible design, the housing includes a first end and a second end that are oppositely arranged in the axial direction, and the first end and the second end both include the transparent portion;

[0028] The medical detection device includes two imaging components, and the two imaging components are respectively arranged corresponding to the two transparent parts;

[0029] The measuring component is mounted on the outer wall of the first end portion or the second end portion; or,

[0030] The medical detection device includes at least a first measuring component and a second measuring component, and the first measuring component and the second measuring component have different measuring ranges. One of the first measuring component and the second measuring component is installed on the outer wall of the first end, and the other is installed on the outer wall of the second end.

[0031] In one possible design, the medical detection device further includes a data transmission component;

[0032] The imaging component includes a lens and an image sensor, and the lens and the image sensor are connected via a mechanical structure and / or glue;

[0033] The image sensor is electrically connected or signal-connected to the data transmission component, and the lens is connected to the data transmission component via a mechanical structure and / or glue.

[0034] In a possible design, the lens is installed in the inner cavity of the housing, and the lens has an effective imaging angle α1, and the transparent portion can cover the space where the effective imaging angle α1 is located;

[0035] The image sensor has a display image angle α2, the transparent portion can cover the space where the display image angle α2 is located, and α1>α2;

[0036] The measuring component is mounted on the outer wall of the housing and is located in the space between the effective imaging angle α1 and the display image angle α2;

[0037] The data transmission component is capable of reading data from the measuring component.

[0038] In a possible design, the lens is installed in the inner cavity of the housing, and the lens has an effective imaging angle α1, and the transparent portion can cover the space where the effective imaging angle α1 is located;

[0039] The image sensor has a display image angle α2, the transparent portion can cover the space where the display image angle α2 is located, and α1>α2;

[0040] The measuring component is mounted on the outer wall of the housing and is located in the space occupied by the display image angle α2;

[0041] The image sensor is capable of recognizing data of the measurement component.

[0042] In a possible design, the measuring component is located in the middle of the space occupied by the display image angle α2.

[0043] In a possible design, the measuring component is adhered to the outer wall of the housing by transparent adhesive material.

[0044] In a possible design, the measuring component is further adhered to the outer wall of the shell by edge sealing glue, and the edge sealing glue covers the outer edge of the measuring component.

[0045] In one possible design, the housing is a capsule-type structure;

[0046] The medical detection equipment is a capsule endoscope.

[0047] A second aspect of an embodiment of the present application provides a measuring component of a medical detection device, the measuring component comprising a polyion gel and a dye, wherein the dye is filled in the polyion gel;

[0048] The dye is capable of changing color when the concentration of the parameter to be measured is different.

[0049] Therefore, the medical detection equipment in the embodiment of the present application can detect various parameters in the digestive tract (including pH value, occult blood concentration, pepsin concentration and trypsin concentration, etc.) by setting up measuring components, thereby improving the accuracy of the detection results of the digestive tract by the medical detection equipment, and making the medical detection equipment have multiple functions, thereby improving its practicality.

[0050] It should be understood that the foregoing general description and the following detailed description are merely illustrative and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0052] Figure 1This is a schematic structural diagram of the medical detection device provided in this application in a first specific embodiment;

[0053] Figure 2 for Figure 1 Exploded diagram;

[0054] Figure 3 for Figure 1 A partial cross-sectional view of

[0055] Figure 4 for Figure 1 Schematic diagram of the structure of the measuring component;

[0056] Figure 5 for Figure 4 A schematic diagram of the structure in which the measuring component is connected to the housing;

[0057] Figure 6 This is a schematic structural diagram of the medical detection device provided in this application in a second specific embodiment;

[0058] Figure 7 This is a schematic structural diagram of the medical detection device provided in this application in a third specific embodiment;

[0059] Figure 8 This is a schematic structural diagram of the medical detection device provided in this application in a fourth specific embodiment;

[0060] Figure 9 This is a schematic structural diagram of the medical detection device provided in this application in a fifth specific embodiment;

[0061] Figure 10 A top view of the sixth specific embodiment of the medical detection device provided by this application;

[0062] Figure 11 A top view of the seventh specific embodiment of the medical detection device provided in this application;

[0063] Figure 12 A top view of the eighth specific embodiment of the medical detection device provided by this application;

[0064] Figure 13 This is a top view of the medical detection device provided in this application in the ninth specific embodiment.

[0065] Reference numerals:

[0066] 1- shell;

[0067] 11- transparent part;

[0068] 12-upper shell;

[0069] 13-lower shell;

[0070] 14-Edge sealing glue;

[0071] 2-Data transmission component;

[0072] 21-data acquisition and processing module;

[0073] 22-antenna;

[0074] 23-battery;

[0075] 3-Measurement components;

[0076] 31-Ontology part;

[0077] 32- plastic material;

[0078] 33-pH measuring component;

[0079] 34-occult blood measurement component;

[0080] 35-Pepsin measurement component;

[0081] 36-Trypsin measurement component;

[0082] 4-imaging components;

[0083] 41-lens;

[0084] 411-lens base;

[0085] 42-image sensor;

[0086] 43-Lighting lamp;

[0087] 431-LED structural parts;

[0088] 5-Infrared switch;

[0089] D1-effective imaging angle boundary;

[0090] D2 - Displays image angle boundaries. DETAILED DESCRIPTION

[0091] In order to better understand the technical solution of the present application, the embodiments of the present application are described in detail below with reference to the accompanying drawings.

[0092] It should be clear that the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0093] The terms used in the embodiments of the present application are for the purpose of describing specific embodiments only and are not intended to limit the present application. The singular forms "a", "an", "the" and "the" used in the embodiments of the present application and the appended claims are also intended to include plural forms unless the context clearly indicates otherwise.

[0094] It should be understood that the term "and / or" as used herein is merely a description of the relationship between associated objects, indicating that three possible relationships exist. For example, "A and / or B" can represent: A exists alone, A and B exist simultaneously, or B exists alone. Furthermore, the character " / " in this document generally indicates that the associated objects are in an "or" relationship.

[0095] It should be noted that the directional words such as "upper", "lower", "left", and "right" described in the embodiments of the present application are described based on the angles shown in the accompanying drawings and should not be understood as limiting the embodiments of the present application. In addition, in the context, it should be understood that when it is mentioned that an element is connected to another element "on" or "under", it can not only be directly connected to the other element "on" or "under", but also be indirectly connected to the other element "on" or "under" through an intermediate element.

[0096] The present application provides a medical detection device, such as Figure 1 and Figure 2 As shown, the medical testing device includes a housing 1 and a measuring component 3. The housing 1 may further include an upper housing 12 and a lower housing 13, which are fixedly connected and enclose an inner cavity of the housing 1. The measuring component 3 is mounted on the outer wall of the housing 1 and is used to measure parameters of the external environment of the housing 1. When the medical testing device is used for digestive tract testing, it can be used to detect parameters such as pH value, occult blood concentration, pepsin concentration, and trypsin concentration in the digestive tract.

[0097] Therefore, the medical detection equipment in the embodiment of the present application can detect various parameters in the digestive tract (including pH value, occult blood concentration, pepsin concentration and trypsin concentration, etc.) by setting the measuring component 3, thereby improving the accuracy of the detection results of the medical detection equipment on the digestive tract.

[0098] Specifically, the measuring component 3 in the embodiment of the present application may include one or more of a pH measuring component 33, an occult blood measuring component 34, a pepsin measuring component 35, and a trypsin measuring component 36, wherein the pH measuring component 33 can be used to measure the pH of the external environment of the shell 1 (e.g., the digestive tract), the occult blood measuring component 34 can be used to measure whether occult blood exists and the concentration of occult blood in the external environment of the shell 1 (e.g., the digestive tract), the pepsin measuring component 35 is used to measure the concentration of pepsin in the external environment of the shell 1 (e.g., the digestive tract), and the trypsin measuring component 36 is used to measure the concentration of trypsin in the external environment of the shell 1 (e.g., the digestive tract).

[0099] Therefore, in this embodiment, the various measurement components 3 described above can be used to measure various parameters of the digestive tract, thereby improving the accuracy of the detection results of the medical detection equipment.

[0100] It should be noted that the medical detection device in the embodiment of the present application does not necessarily include the above-mentioned four measurement components 3, and may include only one or any combination thereof.

[0101] Specifically, if Figure 4 As shown, the measuring component 3 may include a body 31 and an adhesive 32. The adhesive 32 is a transparent, biocompatible adhesive, allowing the body 31 of the measuring component 3 to be attached to the housing 1 of the medical testing device. The adhesive 32 may be a transparent adhesive backing and attached to the transparent portion 11 of the housing 1. The transparent adhesive backing may be, but is not limited to, medical-grade UV adhesive, medical instant adhesive, or medical adhesive backing.

[0102] More specifically, if Figure 5 As shown, the main body 31 of the measuring component 3 is connected to the outer wall of the housing 1 via edge sealing adhesive 14. The edge sealing adhesive 14 is provided on the outer edge of the main body 31, thereby adhering the measuring component 3 to the housing 1 via the edge sealing adhesive 14. The edge sealing adhesive 14 can be, but is not limited to, medical-grade UV adhesive, medical instant adhesive, or medical adhesive.

[0103] In this embodiment, when the outer edge of the measuring component 3 is connected to the shell 1 by the edge sealing glue 14, the connection reliability between the measuring component 3 and the shell 1 can be further improved, and the risk of the measuring component 3 falling off from the shell 1 during use and installation can be reduced.

[0104] Specifically, the measuring component 3 may include a polyion gel and a color-changing dye. Furthermore, the measuring component 3 may be a thin film structure and may be in any shape, such as circular, square, or polygonal. The specific shape of the measuring component 3 is not limited in this application.

[0105] In one possible design, the main body 31 of the measuring component 3 includes a polyion gel and a dye, wherein the dye can change color, the polyion gel is a solid substance formed by polymer cross-linking polymerization, and the dye is filled in the polyion gel. Since there is a strong ionic interaction between the polyion gel and the dye ions, the dye ions can be retained in the polyion gel.

[0106] The polyion gel comprises an ion exchange membrane structure, which is a polymer membrane containing ionic groups that selectively permeates ions in a solution. When the measuring element 3 is located in a solution environment (e.g., the human digestive tract), ions of the substance to be measured (e.g., hydrogen ions) in the solution can enter the polyion gel and bind to the dye in the polyion gel, causing the dye to change color. In addition, in the measuring component 3, the concentration of the ions (e.g., hydrogen ions) of the substance to be measured in the solution is the same as the concentration of the ions (e.g., hydrogen ions) of the substance to be measured in the polyion gel. When the concentration of the ions (e.g., hydrogen ions) of the substance to be measured in the solution increases, they can diffuse into the polyion gel, thereby increasing the concentration of the ions (e.g., hydrogen ions) of the substance to be measured bound to the dye, corresponding to the concentration of one substance to be measured (e.g., the concentration of hydrogen ions, i.e., the pH value of the solution); when the concentration of the ions (e.g., hydrogen ions) of the substance to be measured in the solution decreases, the ions (e.g., hydrogen ions) of the substance to be measured in the polyion gel can diffuse into the solution, thereby reducing the concentration of the ions (e.g., hydrogen ions) of the substance to be measured bound to the dye, corresponding to the concentration of another substance to be measured (e.g., the concentration of hydrogen ions, i.e., the pH value of the solution).

[0107] Therefore, in this embodiment, the dye in the measuring component 3 can combine with or separate from the ions of the substance to be measured (such as hydrogen ions) to form a dynamic equilibrium, and can achieve continuous measurement of the concentration of the substance to be measured.

[0108] Based on this, in the present embodiment, the measuring unit 3 comprising a polyion gel and a dye can be easily integrated (e.g., pasted) with a medical detection device (e.g., a capsule endoscope), and after integration, it is compatible with the hardware of the medical detection device, and does not need to be repackaged. It is only necessary to modify the relevant software to perform pH measurement while realizing endoscopy, so as to improve the accuracy of detection. Simultaneously, by adding a polyion gel, and the ions of the substance to be detected in the solution can penetrate the polyion gel, be combined with the dye, and the ions of the substance to be detected that are combined with the dye can also penetrate the polyion gel, thereby enabling the measuring unit 3 to form a dynamic equilibrium with the ions of the substance to be detected, to realize the continuous measurement of the concentration of the substance to be detected. In addition, the measuring unit 3 also helps to realize industrialization, reduces costs.

[0109] In a specific embodiment, when the medical detection device is used to measure the pH value of the digestive tract, the measuring component 3 includes at least a pH measuring component 33, wherein the main body 31 of the pH measuring component 33 may include a polyion gel and a pH sensitive dye, wherein the pH sensitive dye has different colors when the concentration of hydrogen ions in the solution is different.

[0110] In the medical device field, there are two main approaches to measuring the pH level inside the human body. One approach involves using a pH electrode, which uses materials sensitive to hydrogen ions and electrochemical principles to directly measure the pH value of the environment being tested. This approach, for example, involves using an antimony electrode. Another approach involves using color changes to determine the pH level, but this approach is less accurate. Examples include traditional pH test paper and pH indicators.

[0111] When measuring pH by electrochemical method, the sensor is more complex, and the reference electrode and the test electrode need to be packaged together, and an ion channel must be ensured between them and the test environment. For conventional use scenarios, glass electrodes, antimony electrodes, and hydrogen ion sensitive field effect transistors (H-SFETs) are suitable. + SFETs) can meet application requirements. However, integrating these pH electrodes into capsule endoscopes for measuring the pH of the human digestive tract is extremely difficult and challenging. Furthermore, using antimony electrodes as pH electrodes carries the potential for biotoxicity.

[0112] The method of measuring pH by color change has a long history, but this method cannot continuously measure different pH environments, and it cannot be integrated into a capsule endoscopy device for continuous pH measurement.

[0113] For the above reasons, in the field of medical equipment, there is currently no process that can integrate an endoscope device with a pH measurement sensor. Alternatively, with the current process, the device formed by integrating the endoscope device and the pH measurement sensor has low reliability and high integration process cost.

[0114] In the present embodiment, the medical detection equipment in the present application can obtain the pH information of the digestive tract, that is, the medical detection equipment is integrated with a pH measuring component 33. At the same time, by changing the structure of the pH measuring component 33, the process of integration can be simplified and the integration cost can be reduced. And the pH measuring component 33 including the polyion gel and the pH sensitive dye does not need to use an electrochemical electrode and can be easily integrated (e.g., pasted) with a medical detection equipment (e.g., a capsule endoscope). After integration, it is compatible with the hardware of the medical detection equipment and does not need to be encapsulated twice. It only needs to modify the relevant software to realize pH measurement during endoscopic examination, so as to improve the accuracy of detection. At the same time, by adding the polyion gel, the hydrogen ions in the solution can penetrate the polyion gel and combine with the pH sensitive dye. The hydrogen ions combined with the pH sensitive dye can also penetrate the polyion gel, so that the pH measuring component 33 can form a dynamic equilibrium with the hydrogen ions to realize the continuous measurement of pH. In addition to measuring the pH of the stomach, the pH measuring unit 33 can also measure the pH of organs such as the mouth and intestines, and can display different colors according to the pH of each organ. In addition, the pH measuring unit 3 also helps to achieve industrialization and reduce costs.

[0115] Specifically, by varying the amount or type of pH-sensitive dye in the pH measuring component 33, the measurement range and accuracy of the pH measuring component 33 can be altered. For example, one pH measuring component 33 can measure pH values ​​of 1, 5, 7, and 8, while another pH measuring component 33 can measure pH values ​​of 2, 3, 4, and 6. Therefore, when the medical measuring component includes both of these pH measuring components 33, it can measure pH values ​​within the range of 1 to 8, while maintaining a resolution of 0.5 to 1 pH. The difference between the two pH measuring components 33 lies in the different types of sensitive dyes used, while the polyion gels used in both can be the same.

[0116] In another specific embodiment, when the medical detection device is used to measure whether there is occult blood in the digestive tract and the concentration of the occult blood, the measuring component 3 includes at least a occult blood measuring component 34, wherein the main body 31 of the occult blood measuring component 34 may include polyion gel and methylene blue dye, wherein when the concentration of hemoglobin in the solution is different, the methylene blue dye has different colors.

[0117] In the medical device field, there are two mainstream approaches to occult blood testing in the gastrointestinal tract. The first is the occult blood bead method, which involves swallowing a capsule with a thin string attached. The capsule absorbs gastric fluid at the tail and is then pulled out through the string. A color developer is then added to the gastric fluid-soaked capsule, and the color change is observed to determine whether occult blood is present. The second approach involves detecting occult blood in the gastrointestinal tract using occult blood test strips to detect bleeding in the stool.

[0118] Option 1 is only suitable for occult blood testing in the upper gastrointestinal tract and is invasive, causing discomfort such as vomiting. Option 2 is only suitable for occult blood testing in the lower gastrointestinal tract, especially colorectal testing, and is easily affected by hemorrhoids, leading to false positives.

[0119] In this embodiment, when the occult blood measuring component 34 including the polyion gel and the methylene blue dye is used, the methylene blue dye ions can be retained in the polyion gel and not leaked due to the strong ionic interaction between the polyion gel and the methylene blue dye ions. In addition, the methylene blue dye is a biological dye that has an oxidizing effect on hemoglobin. During the reaction, the methylene blue dye is reduced by hemoglobin and changes from blue to colorless. The depth of the blue varies depending on the hemoglobin concentration, and the occult blood situation can be quantitatively detected by the color change.

[0120] In the present embodiment, methylene blue dye is a non-toxic dye, and its oxidized form is blue, and its reduced form is colorless. Under the environment of high hemoglobin concentration, due to the metabolism of cells, there is a strong reducing ability in the cell. Under the action of glucose-6-phosphate dehydrogenase, the methylene blue dye can be changed from the blue oxidized form to the colorless or light yellow reduced form. Under the environment of low hemoglobin concentration, the cells in the environment have no reducing ability or the reducing ability is extremely weak. At this time, the methylene blue dye is blue or light blue. Therefore, when the methylene blue dye is blue or light blue, it indicates that the hemoglobin in the environment (such as the digestive tract) is at a low concentration. When the methylene blue dye is colorless or light yellow, it indicates that the hemoglobin in the environment (such as the digestive tract) is at a high concentration.

[0121] In addition, the occult blood measuring component 34 in this embodiment can realize continuous measurement and can measure the occult blood concentration of different organs. For example, it can measure the occult blood of organs such as the stomach and intestines.

[0122] Therefore, the medical detection device in the embodiment of the present application integrates the occult blood measuring component 34. At the same time, by changing the structure of the occult blood measuring component 34, the integration process can be simplified and the cost can be reduced. More importantly, the medical detection device can achieve non-invasive detection with high measurement accuracy.

[0123] In another specific embodiment, when the medical detection device is used to measure the pepsin concentration in the digestive tract, the measuring component 3 includes at least a pepsin measuring component 35, wherein the main body 31 of the pepsin measuring component 35 may include polyion gel and bromophenol blue dye, wherein when the concentration of pepsin in the solution (such as the digestive tract) is different, the bromophenol blue dye has different colors.

[0124] Pepsin in human gastric juice has become a biomarker for diseases such as gastritis and gastric cancer. Pepsin secretion decreases in intestinal metaplasia, atypical hyperplasia, and gastric cancer. Pepsin levels increase in Helicobacter pylori infection or in patients with gastric or duodenal ulcers. Numerous statistical analyses have shown that changes in serum pepsinogen levels are associated with gastric diseases, suggesting that serum pepsinogen testing plays an important role in the early diagnosis of gastric cancer.

[0125] Currently, existing technologies mainly use three methods to detect the content of pepsin. The first is serum collection in vitro testing. This method collects serum from the subject for analysis. However, this method collects samples in vivo for in vitro testing to analyze the specific content of pepsin. Therefore, the measured pepsin is a single test, which has limitations for real-time monitoring of the content of gastric protein in gastric juice. In addition, pepsin only works in an acidic environment and loses its activity when the pH is greater than 6. It is easily affected by the environment in vitro, resulting in inaccurate test results. The second method relies on gastroscopy for diagnosis, but gastroscopy is painful, expensive, and limited by the doctor's level, resulting in low patient acceptance. The third method is the pepsin chemiluminescent immunoassay kit detection method, which uses a pepsin chemiluminescent immunoassay kit. The kit includes a pepsin antigen calibrator, sample collection fluid, sample diluent, a pepsin antibody-coated microplate, a pepsin antibody marker, a chemiluminescent substrate solution, and a concentrated washing solution. This kit can detect the amount of pepsin in gastric juice, esophageal contents, and throat secretions. The presence of gastroesophageal reflux can be determined based on the presence of pepsin, and the effectiveness of treatment for gastric lesions and their progression can be determined based on the amount of pepsin. While this method is capable of detecting pepsin, it is complex, requires high standards for both the operator and the testing equipment, and is also expensive.

[0126] In the embodiment of the present application, when the pepsin measuring component 35 including the polyion gel and bromophenol blue dye is used, the bromophenol blue dye ions can be kept in the gel without leaking out due to the strong ionic interaction between the polyion liquid gel and the bromophenol blue dye ions. Bromophenol blue dye is a biological stain. Under different pH conditions, the bromophenol blue dye binds to pepsin with a non-covalent bond. The hydrophobic core of pepsin binds to the non-polar group of bromophenol blue dye. The volume of the aggregate after binding is larger than the volume of the bromophenol blue dye itself, causing the molar absorption coefficient after binding to change, and the light scattering signal to change, thereby showing different colors. The signal intensity is proportional to the number of particles per unit volume, that is, the pepsin concentration, so that the detection of the pepsin concentration can be achieved. During the detection process, the bromophenol blue dye in the pepsin measuring component 35 shows different colors for different concentrations of pepsin, and the concentration can be quantitatively detected by color change.

[0127] In addition, since pepsin can only exist in an acidic environment and will lose its activity and denature in a neutral or alkaline environment, pepsin only exists in the stomach. Based on this, the pepsin measuring component 35 can only be used to measure the concentration of pepsin in the stomach and cannot be used for other organs (because pepsin in other organs is inactivated). During detection, the pepsin in the stomach combines with the bromophenol blue dye, causing the molar absorption coefficient to change, the light scattering signal to change, and then displaying color, and the color is in a certain proportional relationship with the concentration of pepsin, thereby realizing the detection of the corresponding protein. The pepsin measuring component 35 has different color changes in the detection environment of an acidic environment within the range of low concentration to high concentration, and has a certain continuous detection function; but it does not have continuous detection characteristics when the solution environment changes (for example, from the stomach to the duodenum).

[0128] Therefore, the medical detection device in the embodiment of the present application integrates the pepsin measuring component 35. At the same time, by changing the structure of the pepsin measuring component 35, the integration process can be simplified and the cost can be reduced. More importantly, the medical detection device can achieve non-invasive detection with high measurement accuracy.

[0129] In another specific embodiment, when the medical detection device is used to measure the trypsin concentration in the digestive tract, the measuring component 3 includes at least a trypsin measuring component 36, wherein the main body 31 of the trypsin measuring component 36 may include polyion gel and bromocresol purple dye, wherein when the concentration of trypsin in the solution (such as the digestive tract) is different, the bromocresol purple dye has different colors.

[0130] In the embodiment of the present application, when the trypsin measuring component 36 including the polyionic gel and the bromocresol purple dye is used, the bromocresol purple dye ions can be kept in the gel without leaking out due to the strong ionic interaction between the polyionic liquid gel and the bromocresol purple dye ions. Bromocresol purple dye is a biological stain. Under different pH conditions, the bromocresol purple dye binds to trypsin with a non-covalent bond. The hydrophobic core of trypsin binds to the non-polar group of the bromocresol purple dye. The volume of the aggregate after binding is greater than the volume of the bromocresol purple dye itself, causing the molar absorptivity after binding to change, and the light scattering signal to change, thereby displaying different colors. The signal intensity is proportional to the number of particles per unit volume, that is, the trypsin concentration, so that the detection of the trypsin concentration can be achieved. During the detection process, the bromocresol purple dye in the trypsin measuring component 36 displays different colors for different concentrations of trypsin, and the concentration can be quantitatively detected by color change.

[0131] In addition, since trypsin can only exist in a weak alkaline environment and will lose its activity and denature in an acidic environment, trypsin exists in the pancreas, and the trypsin in the pancreas can flow into the duodenum with the pancreatic juice. Based on this, the trypsin measuring component 36 can only be used to measure the trypsin concentration of the pancreas and duodenum, and cannot be used for other organs (because trypsin is inactivated in other organs). During detection, trypsin combines with bromocresol purple dye, causing the molar absorption coefficient to change, the light scattering signal to change, and then displaying color, and the color is in a certain proportional relationship with the concentration of trypsin, thereby realizing the detection of the corresponding protein. Under the detection environment of a weak alkaline environment, the trypsin measuring component 36 has different color changes in the range of low concentration to high concentration, and has a certain continuous detection function; but when the solution environment changes (for example, from the duodenum to the jejunum), it does not have a continuous detection characteristic.

[0132] Therefore, the medical detection device in the embodiment of the present application integrates the trypsin measuring component 36. At the same time, by changing the structure of the trypsin measuring component 36, the integration process can be simplified and the cost can be reduced. More importantly, the medical detection device can achieve non-invasive detection with high measurement accuracy.

[0133] In a specific embodiment, the medical detection device may include multiple measuring components 3, and the ranges of the various measuring components 3 are not exactly the same, and / or the resolutions of the various measuring components 3 are not exactly the same. By combining the multiple measuring components 3, it is possible to meet the measurement requirements of the concentrations of multiple parameters to be measured, thereby improving the measurement accuracy and measurement range. At the same time, when multiple measuring components 3 are included, it is also possible to avoid the failure of a single measuring component 3, resulting in the inability to measure the parameter to be measured or inaccurate measurement results. For example, the medical detection device may include multiple pH measuring components 33, and the ranges of the various pH measuring components 33 are not exactly the same, and / or the resolutions of the various pH measuring components 33 are not exactly the same. By combining the multiple pH measuring components 33, it is possible to meet the measurement requirements of multiple pH values, thereby improving the measurement accuracy and measurement range. It is also possible to avoid the failure of a single pH measuring component 33, resulting in the inability to measure pH information or inaccurate measurement results.

[0134] In addition, the multiple measuring components 3 can be the same type of measuring components 3, or different types of measuring components 3, that is, they can be a combination of multiple measuring components 3. For example, Figure 6In the illustrated embodiment, the medical testing device includes a pH measuring component 33, an occult blood measuring component 34, a pepsin measuring component 35, and a trypsin measuring component 36, thereby enabling the device to measure the pH value, occult blood concentration, pepsin concentration, and trypsin concentration of the digestive tract. Furthermore, the pH measuring component 33, occult blood measuring component 34, pepsin measuring component 35, and trypsin measuring component 36 may each comprise one or more components to improve measurement accuracy. Each of the measuring components 3 may be circular in shape.

[0135] like Figure 7 In the illustrated embodiment, the medical detection device includes a pepsin measuring component 35 and a trypsin measuring component 36, thereby enabling the medical detection device to be used to measure the concentration of pepsin and trypsin. In addition, the pepsin measuring component 35 and the trypsin measuring component 36 may each include one or more to improve the accuracy of the measurement. The shape of each measuring component 3 may be rectangular.

[0136] like Figure 8 In the illustrated embodiment, the medical testing device includes a pH measuring component 33 and an occult blood measuring component 34, enabling the device to measure both pH and occult blood concentration. Furthermore, one or more pH measuring components 33 and occult blood measuring components 34 may be included to improve measurement accuracy. Each measuring component 3 may be circular in shape.

[0137] In the above embodiments, Figure 1 As shown, in the medical detection device, at least a portion of the housing 1 is a transparent portion 11 , which is made of a biocompatible transparent material. That is, through the transparent portion 11 , the environment outside the housing 1 can be observed from the inside of the housing 1 .

[0138] At the same time, the medical detection equipment also includes an imaging component 4, such as Figures 1 to 3 As shown, the imaging component 4 is located in the inner cavity of the housing 1, and specifically includes a lens 41, an image sensor 42, and a lighting lamp 43. The lens 41 can receive light from the external environment of the housing 1 (such as the human digestive tract) through the transparent portion 11 of the housing 1. The image sensor 42 is used to convert the light signal received by the lens 41 into an electrical signal. The lighting lamp 43 is used for illumination and can specifically be an LED lamp. The lighting lamp 43 includes an LED structural member 431. Therefore, the imaging component 4 can capture and observe images of the external environment of the housing 1 through the principle of optical imaging. Based on this, the medical detection equipment in the embodiment of the present application can be an endoscope.

[0139] Furthermore, if Figure 2 and Figure 3As shown, the medical detection equipment also includes a data transmission component 2, which is located in the inner cavity of the shell 1, and specifically includes a data acquisition and processing module 21, an antenna 22 and a battery 23, wherein the battery 23 supplies power to the imaging component 4 and each component in the data transmission component 2, and the data acquisition and processing module 21 is electrically connected or signal-connected to the imaging component 4, so that it can identify and process the information in the imaging component 4, and at the same time, the antenna 22 is used to transmit the obtained information to an external receiving device.

[0140] Specifically, the medical detection equipment can be a capsule endoscope. During processing, the circuit board of the capsule endoscope is first assembled and connected with the imaging component 4 and the data transmission component 2. When the components are connected, they are mainly bonded by UV glue to form a capsule core with a photo-taking function. The capsule core is then loaded into the shell 1. First, the capsule core is loaded into the lower shell 13, and then the upper shell 12 is installed, and the LED structural component 431 is clamped between the upper shell 12 and the lower shell 13, so that the position of the LED structural component 431 inside the capsule is fixed, and then the capsule core is fixed inside the shell 1 to complete the assembly of the capsule endoscope.

[0141] Therefore, when the medical detection device described above is internally mounted on various parts of the human body, its measuring component 3 can display different colors according to the concentration of the parameter to be measured. This color change can be used to quantitatively detect the concentration of the parameter to be measured. This color change can be detected by capturing an image of the measuring component 3 through the lens 41 of the imaging component 4. This color information is then transmitted to an external receiving device via the data transmission component 2 and displayed in real time, thereby facilitating detection. Furthermore, the medical detection device can also capture and observe images of the environment outside the medical detection device through the lens 41 of the imaging component 4. This image information can be transmitted to an external receiving device via the data transmission component 2 and displayed in real time, thereby facilitating the determination of the health status of the affected area.

[0142] The medical detection equipment in the embodiment of the present application can observe the health status of the digestive tract mucosa by setting an imaging component 4 and a data transmission component 2, and can measure the concentration of the parameter to be measured in the digestive tract by setting a measuring component 3, that is, the medical detection equipment integrates an endoscope device and a measuring component 3. At the same time, by changing the structure and type of the measuring component 3, the integration process of the above two components can be simplified and the integration cost can be reduced.

[0143] Specifically, if Figure 3 As shown, the lens 41 is installed in the inner cavity of the housing 1, and the lens 41 has an effective imaging angle α1, and the transparent portion 11 of the housing 1 can cover the space where the effective imaging angle α1 is located, so the field of view of the lens 41 is not blocked. Figure 3As shown, the image sensor 42 has a display image angle α2, and the transparent portion 11 of the housing 1 can also cover the space where the display image angle α2 is located. Therefore, the imaging area of ​​the image sensor 42 is not blocked.

[0144] At the same time, after the lens 41 and the image sensor 42 are installed, α1>α2 is satisfied. That is, although the lens 41 can capture an image within the range corresponding to α1, and the range corresponding to α1 has an effective imaging angle boundary D1, the image sensor 42 can only display the image within the range corresponding to α2, and the range corresponding to α2 has a display image angle boundary D2. For example, the effective imaging angle α1 can be 140°, and the display image angle α2 can be 135°.

[0145] Based on this, in the first specific embodiment, if Figure 10 As shown, the measuring component 3 is installed on the transparent portion 11 and is located in the space between the effective imaging angle α1 and the display image angle α2, that is, the measuring component 3 is located between the effective imaging angle boundary D1 and the display image angle boundary D2, and a plurality of measuring components 3 may be included between the effective imaging angle boundary D1 and the display image angle boundary D2. The plurality of measuring components 3 may be of the same type or of different types, such as Figure 10 In the illustrated embodiment, a pH measuring component 33 and a pepsin measuring component 35 are provided between the effective imaging angle boundary D1 and the display image angle boundary D2, and both of them may be arc-shaped structures.

[0146] At this point, the measurement component 3 cannot be observed within the observation area of ​​image sensor 42. However, the measurement component 3 is within the imaging range of lens 41. Therefore, lens 41 and data transmission assembly 2 can read the color information of the measurement component 3 and transmit this color information to an external receiving device via antenna 22. The external receiving device then displays this color information and, based on this color information, determines the concentration value of the parameter to be measured. Because the measurement component 3 does not occupy the imaging area of ​​image sensor 42, a complete image of the digestive tract mucosa can be observed. This image can be transmitted to the external receiving device via antenna 22 and displayed on the external receiving device, allowing for observation of the health of the digestive tract.

[0147] In another embodiment, Figure 11As shown, the measuring component 3 is mounted on the transparent portion 11 and located within the space occupied by the displayed image angle α2. That is, the measuring component 3 is located within and close to the displayed image angle boundary D2. This prevents the measuring component 3 from occupying the center of the displayed image range, reducing image obstruction by the measuring component 3. At this point, the measuring component 3 is within the imaging area of ​​the image sensor 42. The image sensor 42 transmits the color information of the measuring component 3 to an external receiving device, allowing the user to observe the measuring component 3 displayed in color. This color information is then transmitted to the external receiving device via the antenna 22, whereupon the external receiving device displays the concentration of the parameter to be measured. Therefore, the medical testing device in this embodiment can simultaneously observe the digestive tract mucosa and collect the concentration of the parameter to be measured in the digestive tract.

[0148] One or more measuring components 3 may be provided within the display image angle boundary D2 of the medical detection device, and the multiple measuring components 3 may be of the same or different types, such as Figure 11 In the illustrated embodiment, an occult blood measurement component 34 and a trypsin measurement component 36 are provided within the display image angle boundary D2 , and both may be arc-shaped structures and are close to the display image angle boundary D2 .

[0149] In another specific embodiment, in the medical detection equipment, the measuring component 3 is installed on the transparent part 11 and is located in the space occupied by the display image angle α2, that is, the measuring component 3 is located inside the display image angle boundary D2, and the measuring component 3 can specifically be located in the middle of the space occupied by the display image angle α2.

[0150] At this point, the measuring component 3 is located within the imaging area of ​​the image sensor 42. The image sensor 42 transmits the color information of the measuring component 3 to an external receiving device, allowing the user to observe the measuring component 3 displayed in color. This color information is also transmitted to the external receiving device via the antenna 22, whereupon the external receiving device displays the concentration of the parameter to be measured. Therefore, the medical testing device in this embodiment can simultaneously observe the digestive tract mucosa and collect the concentration of the parameter to be measured in the digestive tract. Furthermore, when the measuring component 3 is located in the center of the space occupied by the display image angle α2, it is easier for the user to observe the measuring component 3, reducing obstruction and thus more accurately obtaining the concentration value of the parameter to be measured.

[0151] The medical detection device can be provided with one or more measuring components 3, and the multiple measuring components 3 can be of the same or different types, such as Figure 12In the illustrated embodiment, multiple pepsin measurement components 35 and trypsin measurement components 36 are disposed between the displayed image angle boundary D2 and the effective imaging angle boundary D1, each located in a corner of the field of view. A pH measurement component 33 is disposed within the displayed image angle boundary D2 and is located in the center of the space occupied by the displayed image angle α2. Each of the aforementioned measurement components 3 may be circular in structure.

[0152] At the same time, if Figure 12 As shown, the medical detection device may further include an infrared switch 5, which can activate the measuring component 3, thereby enabling the measuring component 3 of the medical detection device to start working.

[0153] like Figures 10-12 In the embodiment shown, the image angle boundary D2 and the effective imaging angle boundary D1 of the camera 41 of the imaging component 4 can both be circular and concentric. Figure 13 In the embodiment shown, the effective imaging angle boundary D1 of the camera 41 of the imaging component 4 can be square, and the image angle boundary D2 can be circular. At this time, when the measuring component 3 is located between the image angle boundary D2 and the effective imaging angle boundary D1, it can be located at the four corners of the effective imaging angle boundary D1.

[0154] In a specific embodiment, the arrangement of the multiple measuring components 3 on the outer wall of the housing 1 is a partitioned arrangement or an alternating arrangement. The partitioned arrangement is to divide the outer wall of the housing 1 into several areas, each area is used to set one or more measuring components 3 of the same type. For example, based on the infrared switch 5, the transparent part 11 is evenly divided into two left and right sub-parts, and each sub-part can be set with one or more measuring components 3 of the same type; for example Figure 11 After the transparent portion 11 is evenly divided into two sub-parts, a trypsin measuring component 36 is placed in the left sub-part, and an occult blood measuring component 34 is placed in the right sub-part. The partition arrangement method is to divide the outer wall of the housing 1 into several areas, each area is used to set multiple different types of measuring components 3, and each type of measuring component 3 can be one or more. For example, based on the infrared switch 5, the transparent portion 11 is evenly divided into four sub-parts in a clockwise direction with 90° as the dividing interval. Each sub-part can be equipped with multiple different types of measuring components 3; for example Figure 12The transparent portion 11 is divided clockwise into four equal subsections: [0°, 90°], [90°, 180°], [180°, 270°], and [270°, 360°], with the infrared switch 5 serving as the reference. A trypsin measuring component 36 and a pepsin measuring component 35 are placed in each subsection. This alternating arrangement maximizes detection results and optimizes detection when only a portion of the housing 1 is immersed in a small amount of solution (e.g., gastrointestinal fluid).

[0155] On the other hand, in the medical detection equipment, Figures 6-8 In the illustrated embodiment, the imaging component 4 includes a lens 41, which is used to capture images of the digestive tract and obtain color information of the measuring component 3. In this embodiment, the lens 41 can capture an image of the measuring component 3. This image of the measuring component 3, along with the image of the digestive tract, is transmitted via the data transmission component 2 to an external receiving device. The external receiving device can then identify the concentration of the corresponding parameter to be detected based on the image of the measuring component 3 and display it.

[0156] Of course, if Figure 9 As shown, the medical detection device may also include two imaging components 4. Specifically, its shell 1 includes a first end and a second end (an upper shell 12 and a lower shell 13) that are oppositely arranged along the axial direction, and the first end and the second end can both be provided with a transparent part 11. At the same time, the two imaging components 4 are respectively arranged corresponding to the two transparent parts 11, wherein the medical detection device can be a dual-lens capsule endoscope.

[0157] Specifically, the above-mentioned measuring components 3 can be installed entirely on the outer wall of the first end, or can be installed entirely on the outer wall of the second end. In this case, one imaging component 4 of the medical detection equipment is used to measure the concentration of the parameter to be measured, and the other is used to observe and take pictures.

[0158] Alternatively, in the medical detection device, a first measuring component is installed on the outer wall of the first end of the shell 1, and a second measuring component is installed on the outer wall of the second end. The first end can be provided with one or more first measuring components, and the second end can be provided with one or more second measuring components. The types of the first measuring component and the second measuring component can be the same or different, and the measuring ranges can be the same or different. When the measuring ranges are different, the medical detection device can simultaneously meet the detection requirements of different concentration ranges.

[0159] like Figure 9In the embodiment shown, the first end and the second end of the shell 1 are both provided with a camera 41, and the camera 41 is located in the transparent portion 11 between the first end and the second end. At the same time, the first end can be provided with a pH measuring component 33 and a pepsin measuring component 35, and the second end can be provided with an occult blood measuring component 34 and a trypsin measuring component 36. At this time, in addition to being able to be used to take pictures of the digestive tract, the first end of the medical detection device can also measure the pH value and pepsin concentration in the digestive tract. In addition to being able to be used to take pictures of the digestive tract, the second end of the medical detection device can also measure the occult blood concentration and trypsin concentration in the digestive tract.

[0160] It should be noted that the medical detection device mentioned above may be a capsule endoscope, and of course, may also be other medical detection devices, such as electronic endoscopes and other image measurement devices.

[0161] In a specific embodiment, when the medical detection device is a capsule endoscope, it includes at least one measuring component 3 attached to the surface of the transparent portion 11 of the capsule endoscope and the capsule shell 1. The measuring component 3 may be an annular structure with inner and outer diameters of 5 mm and 6 mm, respectively, and a thickness of 40 μm. Of course, its size and thickness may also be other values. The main body 31 of the measuring component 3 is adhered to the outer surface of the transparent portion 11 using medical UV adhesive (adhesive material 32). The measuring component 3 can be positioned between the effective imaging angle α1 and the display image angle α2 without affecting the image display of the normal user interface. The measurement results of the measuring component 3 can be observed through an external receiving device.

[0162] In another specific embodiment, the capsule endoscopy device includes a capsule endoscope and a measuring component 3 attached to the surface of the transparent portion 11 of the capsule housing 1. The measuring component 3 may be strip-shaped, with a length and width of 6 mm and 2 mm, respectively, and a thickness of 50 μm. Of course, other dimensions and thicknesses are also possible. The body 31 of the measuring component 3 may be attached to the surface of the transparent portion 11 of the housing 1 using a medical adhesive (adhesive material 32), and the measuring component 3 may be positioned within the effective imaging angle α1.

[0163] In addition, an embodiment of the present application also provides a measuring component 3 of a medical detection component, which includes a polyion gel and a dye. The dye is a substance that can have different colors depending on the concentration of the parameter to be measured. The polyion gel is a solid substance formed by polymer cross-linking polymerization, and the dye is filled in the polyion gel. Due to the strong ionic interaction between the polyion gel and the dye ions, the dye ions can be retained in the polyion gel. During operation, ions of the substance to be measured in the environmental solution can pass through the polyion gel and change color after combining with the dye, thereby displaying the concentration of the parameter to be measured in the environmental solution.

[0164] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application shall be included in the scope of protection of the present application.

Claims

1. A medical detection device, characterized in that: The medical detection equipment includes: A housing (1), the housing (1) comprising a transparent portion (11); A measuring component (3) is mounted on the outer wall of the housing (1) and is used to measure the concentration of a parameter to be measured in the external environment of the housing (1); The medical detection device further comprises a data transmission component (2) and an imaging component (4), wherein the imaging component (4) comprises a lens (41) and an image sensor (42), and the image sensor (42) is electrically connected or signal-connected to the data transmission component (2); The lens (41) is installed in the inner cavity of the housing (1), and the lens (41) has an effective imaging angle α1, and the transparent portion (11) can cover the space where the effective imaging angle α1 is located; the image sensor (42) has a display image angle α2, and the transparent portion (11) can cover the space where the display image angle α2 is located, and α1>α2; The measuring component (3) is mounted on the outer wall of the housing (1) and is located in the space between the effective imaging angle α1 and the display image angle α2. The data transmission component (2) is capable of reading data from the measuring component (3).

2. The medical detection device according to claim 1, characterized in that: The measuring component (3) comprises a polyion gel and a dye, wherein the dye is filled in the polyion gel; When the concentration of the parameter to be measured is different, the dye can change the color of the external environment measurement parameter of the measuring component (3).

3. The medical detection device according to claim 2, characterized in that: The measuring component (3) includes one or more of a pH measuring component (33), an occult blood measuring component (34), a pepsin measuring component (35), and a trypsin measuring component (36).

4. The medical detection device according to claim 3, characterized in that: The dye of the pH measuring component (33) is a pH sensitive dye, and the pH sensitive dye can change color in an environment with different pH values.

5. The medical detection device according to claim 4, characterized in that: The hydrogen ions in the environment outside the shell (1) can enter the pH measuring component (33) through the polyion gel, and the hydrogen ions in the pH measuring component (33) can enter the environment outside the shell (1) through the polyion gel; The pH sensitive dye can bind to or dissociate from hydrogen ions to form a dynamic equilibrium.

6. The medical detection device according to claim 3, characterized in that: The dye of the occult blood measuring component (34) includes methylene blue dye, and the methylene blue dye can change color in an environment with different occult blood concentrations.

7. The medical detection device according to claim 6, characterized in that: Hemoglobin in the external environment of the housing (1) can combine with and react with the polyion gel and the methylene blue dye in the occult blood measuring component (34); Under the action of hemoglobin, the methylene blue dye can show color through redox reaction, and the color shown by the methylene blue dye is different when the concentration of the hemoglobin is different.

8. The medical detection device according to claim 3, characterized in that: The dye of the pepsin measuring component (35) includes bromophenol blue dye, which can change color in an environment with different pepsin concentrations.

9. The medical detection device according to claim 8, characterized in that: Pepsin in the external environment of the housing (1) can be combined with the polyion gel and the bromophenol blue dye in the pepsin measuring component (35); The light scattering signal of the bromophenol blue dye after binding changes, showing different colors, and the color of the bromophenol blue dye is different when the concentration of pepsin is different.

10. The medical detection device according to claim 3, characterized in that: The dye of the trypsin measuring component (36) includes bromocresol purple dye, and the bromocresol purple dye can change color in an environment with different trypsin concentrations.

11. The medical detection device according to claim 10, characterized in that: Trypsin in the external environment of the housing (1) can bind to the polyion gel and the bromocresol purple dye in the trypsin measuring component (36); The volume of the bromocresol purple dye after binding changes, and its light scattering signal changes, showing different colors. When the concentration of trypsin is different, the color of the bromocresol purple dye is different.

12. The medical detection device according to claim 3, characterized in that: The arrangement of the plurality of measuring components (3) on the outer wall of the housing (1) is a partitioned arrangement or an alternating arrangement.

13. The medical detection device according to any one of claims 1 to 12, characterized in that: The medical detection device comprises a plurality of measuring components (3); The measuring ranges of the measuring components (3) are not completely the same, and / or the resolutions of the measuring components (3) are not completely the same.

14. The medical detection device according to any one of claims 1 to 12, characterized in that: The imaging component (4) is located in the inner cavity of the shell (1), and the imaging component (4) can observe the environment outside the shell (1) through the transparent portion (11).

15. The medical detection device according to claim 14, characterized in that: The housing (1) comprises a first end and a second end that are arranged opposite to each other in the axial direction, and the first end and the second end both comprise the transparent portion (11); The medical detection device comprises two imaging components (4), and the two imaging components (4) are respectively arranged corresponding to the two transparent parts (11); The measuring component (3) is mounted on the outer wall of the first end portion or the second end portion; or, The medical detection device comprises at least a first measuring component (3) and a second measuring component (3), and the first measuring component (3) and the second measuring component (3) have different measuring ranges. One of the first measuring component (3) and the second measuring component (3) is mounted on the outer wall of the first end portion, and the other is mounted on the outer wall of the second end portion.

16. The medical detection device according to claim 14, characterized in that: The lens (41) is connected to the image sensor (42) via a mechanical structure and / or glue; the lens (41) is connected to the data transmission component (2) via a mechanical structure and / or glue; The housing (1) is a capsule-type structure, and the medical detection device is a capsule-type endoscope.

17. The medical detection device according to any one of claims 1 to 12, characterized in that: The measuring component (3) is adhered to the outer wall of the housing (1) via a transparent adhesive material (32).

18. The medical detection device according to claim 17, characterized in that: The measuring component (3) is also adhered to the outer wall of the housing (1) via edge sealing glue (14), and the edge sealing glue (14) covers the outer edge of the measuring component (3).

Images