An automatic tissue section coverslipping device

By designing a device that automatically adds and places coverslips automatically, the problems of uneven glue drops and operating safety hazards during tissue section sealing are solved, and a high-quality and efficient sealing process is achieved.

CN111579327BActive Publication Date: 2025-05-27GUIZHOU JINYU MEDICAL LAB CENT CO LTD
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Patent Information

Application Number
CN202010472639.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2020-05-29
Publication Date
2025-05-27
Estimated Expiration
2040-05-29

AI Technical Summary

Technical Problem

In the prior art, there is a problem of uneven glue drops during the tissue section sealing process, resulting in too much or too little sealing glue, and there is a safety hazard when the operator picks up the coverslip.

Method used

An automatic sealing device for tissue sections is designed, including multiple automatic sealing glue drop devices and coverslip automatic laying devices, which are all electrically connected to the microprocessor. By automatically dropping the quantitative sealing glue and automatically placing the coverslip on the tissue section.

Benefits of technology

Accurately dropping the sealing glue to tissue sections is achieved, avoiding the problem of too much or too little sealing glue, and reducing the contact between operators and sharp coverslips through automated operations, improving the quality and safety of the sealing.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention discloses an automatic tissue slice sealing device, belonging to the technical field of medical devices. It comprises: a support frame, on which a slide placement plate for placing slides is provided; an automatic sealing glue dripping device, for dripping a quantitative sealing glue on the tissue slice, and a plurality of automatic sealing glue dripping devices are provided, and the plurality of automatic sealing glue dripping devices are installed at intervals on the support frame and located above the slide placement plate; an automatic cover glass placing device, for covering the tissue slice with a cover glass, and a plurality of automatic cover glass placing devices are provided, and the plurality of automatic cover glass placing devices are installed at intervals on the support frame and located above the slide placement plate; a microprocessor, and the automatic sealing glue dripping device and the automatic cover glass placing device are electrically connected to the microprocessor respectively. The automatic tissue slice sealing device in the present invention can automatically drip a quantitative sealing glue and can automatically place a cover glass on the tissue slice.
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Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly relates to an automatic tissue section mounting device. Background Art

[0002] Mounting is to seal and preserve tissue sections between a glass slide and a coverslip, dropping a small amount of mounting adhesive so that it does not come into contact with air, preventing oxidation and fading, which is beneficial for microscopic examination and preservation. Neutral balsam is usually used as the mounting adhesive; however, at present, mounting is mainly carried out manually. During the actual mounting process, there is a problem of uneven dropping of the adhesive, which is likely to cause excessive overflow of the mounting adhesive, generating an odor and having a certain toxicity. If the amount of the mounting adhesive is too small, the tissue on the tissue section is not completely covered or air bubbles are easily generated. In addition, after dropping a small amount of mounting adhesive on the tissue section, a coverslip needs to be placed on the tissue section with the dropped mounting adhesive. At present, during the actual mounting process, an operator needs to pick up the coverslip and place it on the tissue section. Since the coverslip is thin and has a sharp edge, it is not easy to pick up and is likely to scratch the operator during the picking process, presenting a safety hazard. Therefore, there is an urgent need for a mounting device that can automatically drop a quantitative amount of mounting adhesive and automatically place the coverslip on the tissue section. Summary of the Invention

[0003] An object of the present invention is to overcome at least one of the above-mentioned deficiencies of the prior art, and to provide an automatic tissue section mounting device that can automatically drop a quantitative amount of mounting adhesive and automatically place the coverslip on the tissue section.

[0004] The technical solution for the present invention to solve the above technical problems is as follows: An automatic tissue section mounting device, comprising:

[0005] A support frame, on which a glass slide placement plate for placing a glass slide with a tissue section is provided;

[0006] An automatic mounting adhesive dropping device for dropping a quantitative amount of mounting adhesive on the tissue section placed on the glass slide. A plurality of the automatic mounting adhesive dropping devices are provided, and the plurality of automatic mounting adhesive dropping devices are installed at intervals on the support frame and above the glass slide placement plate;

[0007] An automatic coverslip placing device for covering a coverslip on the tissue section placed on the glass slide after dropping a quantitative amount of mounting adhesive. A plurality of the automatic coverslip placing devices are provided, and the plurality of automatic coverslip placing devices are installed at intervals on the support frame and above the glass slide placement plate;

[0008] A microprocessor, and the automatic mounting adhesive dropping device and the automatic coverslip placing device are respectively electrically connected to the microprocessor.

[0009] The beneficial effects of the present invention are as follows: In the present invention, a plurality of automatic cover slip glue dropping devices for dropping a quantitative amount of cover slip glue on tissue sections placed on a glass slide are provided on the support frame. The automatic cover slip glue dropping devices are electrically connected to the microprocessor, which facilitates dropping a quantitative amount of cover slip glue on multiple tissue sections, helps reduce the influence of human factors on the dropped cover slip glue, is conducive to accurately dropping a certain amount of cover slip glue, avoids excessive or insufficient cover slip glue being dropped, and is beneficial to improving the quality of cover slipping. In addition, a plurality of automatic cover slip placing devices for placing a cover slip on a tissue section placed on a glass slide after dropping a quantitative amount of cover slip glue are provided. The automatic cover slip placing devices are electrically connected to the microprocessor. By using the automatic cover slip placing devices to place the cover slip on the cover slip glue on the tissue section, it helps avoid the safety hazard of the operator being scratched when picking up the cover slip. Thus, the automatic tissue section cover slipping device in the present invention can automatically drop a quantitative amount of cover slip glue and can automatically place the cover slip on the tissue section, avoiding excessive or insufficient cover slip glue being dropped, and improving the quality and efficiency of cover slipping.

[0010] In addition, on the basis of the above technical solutions, the present invention can be further improved and can also have the following additional technical features.

[0011] According to an embodiment of the present invention, the glass slide placement plate is linearly slidably installed on the support frame and can be slid to directly below the automatic cover slip glue dropping device and the automatic cover slip placing device. In this embodiment, by linearly slidably installing the glass slide placement plate on the support frame, the glass slide and the tissue section installed on the glass slide placement plate can be exactly moved to directly below the automatic cover slip glue dropping device and the automatic cover slip placing device by moving the glass slide placement plate, which facilitates dropping cover slip glue on the tissue section and placing a cover slip on the tissue section.

[0012] According to an embodiment of the present invention, the automatic cover slip glue dropping device includes:

[0013] A housing, in which a cover slip glue storage cavity for storing cover slip glue is provided;

[0014] A cover slip glue delivery pipe, with two ends being an input end and an output end respectively. The input end extends into the cover slip glue storage cavity and is in communication with the cover slip glue storage cavity, and the output end penetrates through the housing;

[0015] A cover slip glue suction and discharge device for sucking the cover slip glue stored in the cover slip glue storage cavity into the cover slip glue delivery pipe and discharging the cover slip glue sucked into the cover slip glue pipe from the cover slip glue delivery pipe. The cover slip glue suction and discharge device is connected to the cover slip glue delivery pipe and is in communication with the cover slip glue delivery pipe, and the cover slip glue suction and discharge device is electrically connected to the microprocessor;

[0016] A first one-way valve is connected to the sealant delivery pipe and is located between the input end and the connection between the sealant suction and discharge device and the sealant delivery pipe. The one-way conduction direction of the first one-way valve is from the input end to the connection between the sealant suction and discharge device and the sealant delivery pipe;

[0017] A second one-way valve is connected to the sealant delivery pipe and is located between the output end and the connection between the sealant suction and discharge device and the sealant delivery pipe. The one-way conduction direction of the second one-way valve is from the connection between the sealant suction and discharge device and the sealant delivery pipe to the output end; the first one-way valve and the second one-way valve are alternately conducted and closed under the action of the sealant suction and discharge device, and a quantitative amount of sealant is output from the output end of the sealant delivery pipe after completing an alternating process of conduction and closing.

[0018] In this embodiment, a sealant storage cavity for storing sealant is provided in the housing, which is convenient for storing sealant in the housing. A first one-way valve and a second one-way valve are also connected to the sealant delivery pipe, and a sealant suction and discharge device is connected between the first one-way valve and the second one-way valve. The sealant suction and discharge device is used to suck the sealant stored in the sealant storage cavity into the sealant delivery pipe and convey the sealant. The first one-way valve and the second one-way valve are alternately conducted and closed under the action of the sealant suction and discharge device, and a quantitative amount of sealant is output from the output end of the sealant delivery pipe after completing an alternating process of conduction and closing. Thus, by driving the driving mechanism once or several times, an appropriate amount of sealant can be output and dropped on the tissue section for dropping glue on the tissue section, so as to facilitate placing a cover glass on the tissue section for sealing. Therefore, the amount of sealant dropped on the tissue section is appropriate and the added amount can be controlled, avoiding too much or too little sealant being dropped, which is beneficial to improving the quality of sealing. At the same time, the consistency of sealing the tissue section is improved.

[0019] According to an embodiment of the present invention, the sealant suction and discharge device includes a suction and discharge pipe and a driving mechanism for enabling the suction and discharge pipe to suck and discharge sealant. One end of the suction and discharge pipe is connected to the sealant delivery pipe and is in communication with the sealant delivery pipe. One end of the suction and discharge pipe is connected to the sealant delivery pipe and is in communication with the sealant delivery pipe. The driving mechanism drives the suction and discharge pipe to suck and output sealant, and the driving mechanism is electrically connected to the microprocessor. The sealant suction and discharge device in this embodiment includes a suction and discharge pipe and a driving mechanism for enabling the suction and discharge pipe to suck and discharge sealant, which is convenient for driving the suction and discharge pipe to suck and output sealant through the driving mechanism.

[0020] According to an embodiment of the present invention, a sealing film glue suction and discharge cavity is provided in the suction and discharge pipe, and the volume of the sealing film glue suction and discharge cavity is equal to the volume of the sealing film glue required for one-time sealing or the volume of several multiples of the sealing film glue suction and discharge cavity is equal to the volume of the sealing film glue required for one-time sealing; the driving mechanism includes:

[0021] A piston, which is adaptively and slidably installed in the sealing film glue suction and discharge cavity of the suction and discharge pipe;

[0022] A push rod, one end of which is connected to the piston, and the other end extends out of the housing to form an extended end;

[0023] An electric push rod, which is fixedly connected to the support frame. An expansion rod is provided on the electric push rod, and the expansion rod is fixedly connected to the extended end of the push rod. The electric push rod is electrically connected to the microprocessor.

[0024] The driving mechanism in this embodiment includes a piston, a push rod and an electric push rod. The piston is adaptively installed in the sealing film glue suction and discharge cavity. One end of the push rod is connected to the piston, and the other end passes through the housing. The piston is driven to move by pushing and pulling the push rod by the electric push rod. When the electric push rod pulls the push rod out of the housing, the piston moves outwards by a certain displacement, and the sealing film glue between the first one-way valve and the second one-way valve is adsorbed, while the second one-way valve closes and the first one-way valve opens, and a certain amount of sealing film glue enters the sealing film glue output pipe between the first one-way valve and the second one-way valve; when the electric push rod pushes the push rod into the housing, the piston moves forward to restore its original position, and the sealing film glue between the first one-way valve and the second one-way valve is squeezed, while the first one-way valve closes and the second one-way valve opens, and a certain amount of sealing film glue is output from the output end of the sealing film glue output pipe; thus, by pushing and pulling the push rod, the amount of the sealing film glue dropped on the tissue section is appropriate and the added amount can be controlled, avoiding too much or too little of the dropped sealing film glue.

[0025] According to an embodiment of the present invention, a stop baffle is provided on the push rod, and a first spring is installed between the stop baffle and the sealing film glue delivery pipe. The first spring is sleeved on the stop baffle, and one end of the first spring abuts against the stop baffle, and the other end abuts against the suction and discharge pipe or the sealing film glue delivery pipe. In this embodiment, by installing a first spring between the stop baffle and the sealing film glue delivery pipe, and the first spring is sleeved on the push rod, when the electric push rod applies pressure to the push rod to push the push rod into the housing, the first spring is elastically deformed under pressure, the piston moves forward and squeezes the sealing film glue, when the electric push rod pulls the push rod out of the housing, the first spring restores its elasticity, the expansion rod on the electric push rod resets, the piston resets and sucks a certain amount of sealing film glue into the sealing film glue delivery pipe, facilitating the next operation of pushing the push rod, so that the piston performs the next extrusion of the sealing film glue to output a certain amount of the sealing film glue. In addition, the first spring in this embodiment can buffer the thrust and pulling force of the electric push rod, which is beneficial to improving the uniformity of dropping the sealing film glue.

[0026] According to an embodiment of the present invention, the cover glass automatic loading device includes:

[0027] A body, in which there is a cover glass storage cavity for storing cover glasses, and there is also a cover glass pushing channel for sequentially passing a single cover glass. One end of the cover glass pushing channel communicates with the cover glass storage cavity, and the other end extends out of the body.

[0028] A cover glass pushing device for pushing the cover glass stored in the cover glass storage cavity out through the cover glass pushing channel. The cover glass pushing device includes a cover glass pushing plate and a driving mechanism for driving the cover glass pushing plate to move linearly. One end of the cover glass pushing plate is connected to the driving mechanism, and the other end can extend into and withdraw from the cover glass pushing channel and the cover glass storage cavity under the drive of the driving mechanism.

[0029] A cover glass pressing device for pressing the cover glass stored in the cover glass storage cavity to flatten the cover glass and make multiple cover glasses close to each other. A pressing rod is provided on the cover glass pressing device, and the pressing rod can extend into the cover glass storage cavity.

[0030] In this embodiment, by providing a cover glass storage cavity in the body, it is convenient to store cover glasses in the body; by providing a cover glass pushing device to push the cover glass stored in the cover glass storage cavity out through the cover glass pushing channel, the cover glass pushing device includes a cover glass pushing plate and a driving mechanism for driving the cover glass pushing plate to move linearly. Under the drive of the driving mechanism, the cover glass pushing plate can sequentially push the cover glasses stored in the cover glass storage cavity out, so as to facilitate pushing the cover glass out through the cover glass pushing channel and placing the cover glass on the mounting adhesive of the tissue section, which is beneficial to avoiding the safety hazard of scratching the operator when the operator picks up the cover glass. In addition, by providing a cover glass pressing device for pressing the cover glass stored in the cover glass storage cavity to flatten the cover glass and make multiple cover glasses close to each other, it is beneficial for multiple cover glasses to be close to each other and ensure that only one cover glass is pushed out by the cover glass pushing plate in the process of pushing the cover glass once, and to avoid the chaos of the cover glasses placed in the cover glass storage cavity affecting the smoothness of pushing. Further, after the cover glass pushing plate withdraws from the cover glass storage cavity, the cover glass stored in the cover glass storage cavity moves downward under the pressure of the cover glass pressing device, which is convenient for the cover glass pushing plate to push out the next cover glass.

[0031] According to an embodiment of the present invention, the cover glass pushing channel is horizontally arranged and flush with the bottom of the cover glass storage cavity. A through groove for adapting to pass through the cover glass pushing plate is provided on the body opposite to the cover glass pushing channel. The cover glass pushing plate is horizontally arranged, and one end of it can pass through the through groove and extend into the cover glass storage cavity and the cover glass pushing channel. In this embodiment, the cover glass pushing channel is horizontally arranged and flush with the bottom of the cover glass storage cavity. After the cover glass pushing plate is withdrawn from the cover glass storage cavity, the cover glass stored in the cover glass storage cavity moves downward under the pressure of the cover glass pressing device, so that the cover glass at the bottom is flush with the cover glass pushing channel, which is convenient for the cover glass pushing plate to push out of the body under the drive of the drive mechanism.

[0032] According to an embodiment of the present invention, the cover glass pressing device includes:

[0033] A support seat is vertically and slidably installed on the body and extends upward. The pressing rod is vertically and slidably installed on the support seat and is located directly above the cover glass storage cavity. The upper end of the pressing rod passes through the support seat, and the lower end can extend into the cover glass storage cavity;

[0034] A second spring is sleeved on the pressing rod. A stop plate is provided at the upper end of the pressing rod, and a pressing plate is provided at the lower end of the pressing rod. The upper end of the second spring abuts against the lower side of the support seat, and the lower end of the second spring abuts against the upper side of the pressing plate;

[0035] A locking member is used to lock the support seat and the body to fix the support seat at different height positions, so that the second spring installed on the pressing rod generates elastic deformation to press the cover glass stored in the cover glass storage cavity.

[0036] In this embodiment, the support seat is vertically and slidably installed on the body, the pressing rod is vertically and slidably installed on the support seat and is located directly above the cover glass storage cavity. The upper end of the pressing rod passes through the support seat, and the lower end can extend into the cover glass storage cavity. The support seat and the body are locked by a locking member to fix the support seat at different height positions, which is convenient for sliding the support seat upward or removing the support seat to add cover glass into the cover glass storage cavity. In addition, a second spring is sleeved on the pressing rod. By adjusting the fixed height of the support seat in the vertical direction, the pressing degree of the second spring on the cover glass stored in the cover glass storage cavity is adjusted, so that the pressing degree of the second spring on the cover glass is appropriate, which is convenient for the cover glass pushing plate to push out the cover glass in the cover glass storage cavity, and avoids the cover glass from being broken due to excessive pressure of the second spring on the slide glass.

[0037] According to an embodiment of the present invention, the automatic tissue section mounting device further includes:

[0038] Suspension beam, the suspension beam includes a first suspension beam and a second suspension beam, the first suspension beam and the second suspension beam are arranged in parallel, both ends of the first suspension beam and the second suspension beam are slidably mounted on the left and right ends of the support frame respectively, and can slide in the front - rear direction relative to the slide - placing plate. A plurality of the cover - slip glue automatic dispensing devices are spacedly installed on the first suspension beam, and a plurality of the cover - glass automatic placing devices are spacedly installed on the second suspension beam.

[0039] In this embodiment, by providing a suspension beam which is slidably mounted on the support frame, it is convenient to slide the suspension beam in the front - rear direction to adjust the position of the suspension beam, and it is convenient to adjust the positions of the cover - slip glue automatic dispensing device and the cover - glass automatic placing device in the front - rear direction.

[0040] According to an embodiment of the present invention, the support frame includes:

[0041] Bottom support plate;

[0042] Vertical support rods, there are multiple vertical support rods vertically connected to the rear end of the bottom support plate and extending upward to form extension ends;

[0043] Cross beam, connected to the extension ends of the multiple vertical support rods;

[0044] Support longitudinal beams, there are two support longitudinal beams connected to the left and right ends of the cross beam and extending forward to form extension ends, and both ends of the suspension beam are slidably mounted on the support longitudinal beams;

[0045] Placing - plate mounting seat, located in the front part of the vertical support rods, and the slide - placing plate is detachably mounted on the placing - plate mounting seat.

[0046] The support frame of this embodiment includes two support longitudinal beams connected to the left and right ends of the cross beam, which is convenient for slidably mounting the suspension beam and convenient for longitudinally sliding the suspension beam; in addition, the support frame also includes a placing - plate mounting seat, which is convenient for mounting the slide - placing plate below the suspension beam, and is beneficial for the cover - slip glue automatic dispensing device mounted on the suspension beam to drip glue on the tissue section, so as to place a cover - glass on the tissue section for sealing. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] In order to more clearly illustrate the technical solutions in the present invention, the following will briefly introduce the drawings required for description in the embodiments. Obviously, the following - described drawings are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0048] Figure 1It is a schematic structural diagram of an automatic tissue section sealing device according to an embodiment of the present invention;

[0049] Figure 2 for Figure 1 Front view after straightening;

[0050] Figure 3 for Figure 2 A top view of

[0051] Figure 4 for Figure 2 Left view of

[0052] Figure 5 This is a schematic structural diagram of an automatic glue-drip device for sealing glue according to an embodiment of the present invention;

[0053] Figure 6 A cross-sectional view of an automatic glue dispensing device for sealing glue according to an embodiment of the present invention;

[0054] Figure 7 It is a structural schematic diagram of the automatic cover glass placing device according to an embodiment of the present invention;

[0055] Figure 8 4 is a cross-sectional view of a cover glass automatic placing device according to an embodiment of the present invention.

[0056] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0057] 1. Support frame, 2. Automatic cover slip glue dripping device, 3. Automatic cover glass placing device, 4. Locking part one, 5. Locking part two, 6. Slide glass placing plate, 7. Locking part three, 8. Electric push rod one, 10. Bottom support plate, 11. Vertical support rod, 12. Cross beam, 13. Support longitudinal beam, 14. Sliding mounting seat, 15. First suspension beam, 16. Second suspension beam, 17. Placing plate mounting seat, 18. Horizontal support beam, 20. Upper shell, 21. Lower shell, 22. Cover slip glue conveying pipe, 23. Cover slip glue suction and discharge device, 30. Body, 31. Cover glass pushing device, 32. Cover glass pressing device, 33. Locking part four, 34. Spring two, 35. Connection structure, 36. Cover glass, 60. Slide glass mounting groove, 61. Slide block, 131. Slide rail, 171. Bottom plate, 172. Support rod, 173. Placing plate mounting board, 174. Guide slide rail, 201. Vertical connecting rod, 202. Locking hole, 203. Horizontal connecting plate, 204. Cover slip glue adding port plug, 205. Cover slip glue storage cavity, 221. Input pipe, 222. Connecting elbow, 223. First one-way valve, 224. Three-way connecting pipe, 225. Second one-way valve, 226. Output nozzle, 231. Suction and discharge pipe, 232. Piston, 233. Cover slip glue suction and discharge cavity, 234. Limit connecting pipe, 235. Stop disk, 236. Spring one, 237. Push and pull rod, 238. Limit plate, 239. Connection disk one, 301. Extension plate, 302. Cover glass storage cavity, 303. Cover glass delivery nozzle, 304. Cover glass pushing channel, 305. Slide groove, 306. Protective cover, 311. Electric push rod two, 312. Push rod, 313. Cover glass push plate, 321. Support slide plate, 322. Limit guide rail, 323. Horizontal support plate, 324. Pressing rod, 325. Stop baffle, 326. Pressing plate, 351. Horizontal connecting plate one, 352. Vertical connecting plate, 353. Horizontal connecting plate two. Detailed implementation manners

[0058] To make the objectives, technical solutions and advantages of this application clearer, the following will further describe the implementation manners of this application in detail with reference to the accompanying drawings.

[0059] To be able to more clearly understand the above objectives, features and advantages of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and specific implementation manners. It should be noted that, without conflict, the embodiments of this application and the features in the embodiments can be combined with each other.

[0060] Many specific details are set forth in the following description in order to fully understand the present invention. However, the present invention can also be implemented in other ways different from those described herein. Therefore, the protection scope of the present invention is not limited by the specific embodiments disclosed below.

[0061] An embodiment of the present disclosure provides an automatic tissue section mounting device, as Figures 1 to 4 shown, including: a support frame 1, on which a slide placement plate 6 for placing a slide with tissue sections is provided; an automatic mounting glue dropping device 2 for dropping a quantitative amount of mounting glue on the tissue sections placed on the slide. There are multiple automatic mounting glue dropping devices 2, and the multiple automatic mounting glue dropping devices 2 are installed on the support frame 1 at intervals and are located above the slide placement plate 6; a cover glass automatic placing device 3 for covering a cover glass 36 on the tissue sections placed on the slide after dropping a quantitative amount of mounting glue. There are multiple cover glass automatic placing devices 3, and the multiple cover glass automatic placing devices 3 are installed on the support frame 1 at intervals and are located above the slide placement plate 6; a microprocessor, and the automatic mounting glue dropping device 2 and the cover glass automatic placing device 3 are respectively electrically connected to the microprocessor.

[0062] In this embodiment, as Figures 1 to 4 shown, by providing multiple automatic mounting glue dropping devices 2 on the support frame 1 for dropping a quantitative amount of mounting glue on the tissue sections placed on the slide, and the automatic mounting glue dropping device 2 is electrically connected to the microprocessor, it is convenient to drop a quantitative amount of mounting glue on multiple tissue sections, which is beneficial to reducing the influence of human factors on the dropped mounting glue, is beneficial to accurately dropping a certain amount of mounting glue, avoiding too much or too little dropped mounting glue, and is beneficial to improving the quality of mounting. In addition, by providing multiple cover glass automatic placing devices 3 for covering a cover glass 36 on the tissue sections placed on the slide after dropping a quantitative amount of mounting glue, and the cover glass automatic placing device 3 is electrically connected to the microprocessor, and placing the cover glass 36 on the mounting glue on the tissue section through the cover glass automatic placing device 3 is beneficial to avoiding the safety hazard of scratching the operator when the operator picks up the cover glass 36. Further, the automatic mounting glue dropping device 2 and the cover glass automatic placing device 3 in this embodiment can work simultaneously, which is beneficial to improving the mounting efficiency.

[0063] An embodiment of the present invention, as Figures 1 to 4 shown, the slide placement plate 6 is linearly slidably installed on the support frame 1 and can slide to directly below the automatic mounting glue dropping device 2 and the cover glass automatic placing device 3. In this embodiment, by linearly slidably installing the slide placement plate 6 on the support frame 1, the slide and the tissue sections installed on the slide placement plate 6 can be exactly moved to directly below the automatic mounting glue dropping device 2 and the cover glass automatic placing device 3 by moving the slide placement plate 6, which is convenient for dropping mounting glue on the tissue sections and covering the cover glass 36 on the tissue sections.

[0064] In this embodiment, the support frame 1 of this embodiment includes a placement plate mount 17. The placement plate mount 17 is located at the front of the vertical support rod 11. A plurality of guide slide rails 174 are provided on the placement plate mount 17. Corresponding to the guide slide rails 174 at the bottom of the slide glass placement plate 6, there are a plurality of sliders 61 that are slidably connected to the guide slide rails 174 in a matching manner. The slide glass placement plate 6 is mounted on the plurality of sliders 61. The guide slide rails 174 in this embodiment are of a T-shaped structure.

[0065] An embodiment of the present invention, as Figure 5 and Figure 6 shown, the cover slip glue automatic dispensing device 2 includes: a housing, and a cover slip glue storage cavity 205 for storing cover slip glue is provided inside the housing; a cover slip glue delivery pipe 22, the two ends of the cover slip glue delivery pipe 22 are respectively an input end and an output end. The input end extends into the cover slip glue storage cavity 205 and is communicated with the cover slip glue storage cavity 205, and the output end penetrates through the housing; a cover slip glue suction and discharge device 23, which is used to suck the cover slip glue stored in the cover slip glue storage cavity 205 into the cover slip glue delivery pipe 22 and output the cover slip glue sucked into the cover slip glue pipe from the cover slip glue delivery pipe 22. The cover slip glue suction and discharge device 23 is connected to the cover slip glue delivery pipe 22 and is communicated with the cover slip glue delivery pipe 22, and the cover slip glue suction and discharge device 23 is electrically connected to the microprocessor; a first one-way valve 223, which is connected to the cover slip glue delivery pipe 22 and is located between the input end and the connection of the cover slip glue suction and discharge device 23 and the cover slip glue delivery pipe 22. The one-way conduction direction of the first one-way valve 223 is from the input end to the connection of the cover slip glue suction and discharge device 23 and the cover slip glue delivery pipe 22; a second one-way valve 225, which is connected to the cover slip glue delivery pipe 22 and is located between the output end and the connection of the cover slip glue suction and discharge device 23 and the cover slip glue delivery pipe 22. The one-way conduction direction of the second one-way valve 225 is from the connection of the cover slip glue suction and discharge device 23 and the cover slip glue delivery pipe 22 to the output end; the first one-way valve 223 and the second one-way valve 225 are alternately conducted and closed under the action of the cover slip glue suction and discharge device 23, and a quantitative cover slip glue is output from the output end of the cover slip glue delivery pipe 22 in the process of completing an alternating process of conduction and closing.

[0066] In this embodiment, as Figure 6As shown in the figure, by providing a mounting medium storage cavity 205 for storing mounting medium inside the housing, it is convenient to store the mounting medium inside the housing. A first one-way valve 223 and a second one-way valve 225 are also connected to the mounting medium delivery pipe, and a mounting medium suction and discharge device 23 is connected between the first one-way valve 223 and the second one-way valve 225. The mounting medium suction and discharge device 23 is used to suck the mounting medium stored in the mounting medium storage cavity 205 into the mounting medium delivery pipe 22 and to deliver the mounting medium. The first one-way valve 223 and the second one-way valve 225 are alternately opened and closed under the action of the mounting medium suction and discharge device 23, and a fixed amount of mounting medium is output from the output end of the mounting medium delivery pipe 22 during one alternation process of opening and closing. Thus, by driving the driving mechanism once or several times, an appropriate amount of mounting medium can be output and dropped onto the tissue section for dropping the mounting medium on the tissue section, so as to facilitate placing a coverslip 36 on the tissue section for mounting. As a result, the amount of mounting medium dropped on the tissue section is appropriate and the added amount can be controlled, avoiding too much or too little mounting medium being dropped, which is beneficial to improving the quality of mounting. At the same time, the consistency of mounting the tissue section is improved.

[0067] In this embodiment, as Figure 6 shown, the input end of the mounting medium delivery pipe 22 is specifically an input pipe 221. The rear end of the input pipe 221 is connected to a connecting elbow 222. The rear end of the connecting elbow 222 is connected to a first one-way valve 223. The rear end of the first one-way valve 223 is connected to a tee connecting pipe 224. The mounting medium suction and discharge device 23 is connected to one branch of the tee connecting pipe 224. The rear end of the other branch of the tee connecting pipe 224 is connected to a second one-way valve 225. The rear end of the second one-way valve 225 is connected to an output nozzle 226. In this embodiment, the output nozzle 226 serves as the output end.

[0068] In this embodiment, as Figure 5 and Figure 6 shown, in order to facilitate adding mounting medium to the mounting medium storage cavity 205, a mounting medium addition port is provided on the upper side surface of the upper housing 20, and the mounting medium addition port is blocked by a mounting medium addition port plug 204.

[0069] In one embodiment of the present invention, as Figure 6 shown, the mounting medium suction and discharge device 23 includes a suction and discharge pipe 231 and a driving mechanism for enabling the suction and discharge pipe 231 to suck and discharge the mounting medium. One end of the suction and discharge pipe 231 is connected to the mounting medium delivery pipe and is in communication with the mounting medium delivery pipe 22. One end of the suction and discharge pipe 231 is connected to the mounting medium delivery pipe 22 and is in communication with the mounting medium delivery pipe 22. The driving mechanism drives the suction and discharge pipe 231 to suck and output the mounting medium. The mounting medium suction and discharge device 23 in this embodiment includes a suction and discharge pipe 231 and a driving mechanism for enabling the suction and discharge pipe 231 to suck and discharge the mounting medium, which facilitates driving the suction and discharge pipe 231 to suck and output the mounting medium by the driving mechanism.

[0070] In one embodiment of the present invention, as Figure 6 shown, a sealing sheet glue suction and discharge cavity 233 is provided in the suction and discharge pipe 231, and the volume of the sealing sheet glue suction and discharge cavity 233 is equal to the volume of the sealing sheet glue required for one-time sealing, or the volume of several multiples of the sealing sheet glue suction and discharge cavity 233 is equal to the volume of the sealing sheet glue required for one-time sealing; the driving mechanism includes: a piston 232, which is slidably installed in the sealing sheet glue suction and discharge cavity 233 of the suction and discharge pipe 231; a push-pull rod 237, one end of which is connected to the piston 232, and the other end extends out of the housing to form an extended end.

[0071] In this embodiment, as Figure 5 and Figure 6 shown, the driving mechanism includes a piston 232, a push rod 312 and an electric push rod. The piston 232 is fitted and installed in the sealing sheet glue suction and discharge cavity 233. One end of the push-pull rod 237 is connected to the piston 232, and the other end passes through the housing. The push-pull rod 237 is pushed and pulled by the electric push rod to drive the piston 232 to move. When the electric push rod pulls the push-pull rod 237 out of the housing, the piston 232 moves outwards by a certain displacement, and the sealing sheet glue between the first one-way valve 223 and the second one-way valve 225 is adsorbed, while the second one-way valve 225 closes and the first one-way valve 223 opens, and a certain amount of sealing sheet glue enters the sealing sheet glue output pipe between the first one-way valve 223 and the second one-way valve 225; when the electric push rod pushes the push rod 312 into the housing, the piston 232 moves forward to return to its original position, and the sealing sheet glue between the first one-way valve 223 and the second one-way valve 225 is squeezed, while the first one-way valve 223 closes and the second one-way valve 225 opens, and a certain amount of sealing sheet glue is output from the output end of the sealing sheet glue output pipe; thus, by pushing and pulling the push rod 312 by the electric push rod, the amount of the sealing sheet glue dropped on the tissue section is appropriate and the added amount can be controlled, avoiding too much or too little of the dropped sealing sheet glue. The electric push rod in this embodiment is the first electric push rod 8, and the telescopic rod on the first electric push rod 8 is coaxially arranged with the push rod 312. The first electric push rod 8 in this embodiment is fixed to the front part of the support frame 1. Further, the first electric push rod 8 is specifically fixedly connected to the horizontal support beam 18. The two ends of the horizontal support beam 18 in this embodiment are respectively fixedly connected to the lower sides of the support longitudinal beams 13 at the left and right ends of the support frame 1.

[0072] In one embodiment of the present invention, as Figure 6 shown, two limiting bumps are provided in the suction and discharge pipe 231. The limiting bumps are connected to the inner wall of the suction and discharge pipe 231 and protrude into the suction and discharge pipe 231. A sealing sheet glue suction and discharge cavity 233 is defined between the two limiting bumps. In this embodiment, a sealing sheet glue suction and discharge cavity 233 is defined between the two limiting bumps. The piston 232 is fitted and installed in the sealing sheet glue suction and discharge cavity 233. The two limiting bumps limit the piston 232 and limit the displacement of the piston 232, so that the amount of the sealing sheet glue discharged each time is the same.

[0073] An embodiment of the present invention, as Figure 6 shown, a limiting plate 238 is provided on the push-pull rod 237, and a first spring 236 is installed between the limiting plate 238 and the sealing film adhesive conveying pipe 22. The first spring 236 is sleeved on the push-pull rod 237, and one end of the first spring 236 abuts against the push-pull rod 237, and the other end abuts against the suction and discharge pipe 231 or the sealing film adhesive conveying pipe 22. In this embodiment, by installing the first spring 236 between the limiting plate 238 and the sealing film adhesive conveying pipe 22, and the first spring 236 is sleeved on the push-pull rod 237, the push-pull rod 237 is pressured to push the push-pull rod 237 into the housing. The first spring 236 undergoes elastic deformation under the pressure, the piston 232 moves forward and extrudes the sealing film adhesive. When the push-pull rod 237 is released, the first spring 236 restores its elasticity, the push rod 312 resets, the piston 232 resets and sucks a certain amount of sealing film adhesive into the sealing film adhesive conveying pipe 22, facilitating the next operation of pushing the push rod 312, so that the piston 232 performs the next extrusion of the sealing film adhesive to output a certain amount of the sealing film adhesive. Further, the first spring in this embodiment can buffer the thrust and pull force of the electric push rod, which is beneficial to improving the uniformity of dripping the sealing film adhesive. Further, a first connecting disc 239 is provided at the extending end of the push rod in this embodiment, and a second connecting disc is provided at the end of the telescopic rod of the electric push rod. The first connecting disc 239 and the second connecting disc are fixedly connected by bolts.

[0074] In this embodiment, as Figure 6 shown, the left end of the suction and discharge pipe 231 is connected to the tee connecting pipe 224, and the right end is connected to the limiting connecting pipe 234. A limiting convex block is provided on the limiting connecting pipe 234 of this embodiment, and a limiting convex block is provided at the left end of the suction and discharge pipe 231. A sealing film adhesive suction and discharge cavity 233 is defined between the limiting connecting pipe 234 and the suction and discharge pipe 231. Further, a limiting plate 238 is provided at the extending end of the push-pull rod 237 in this embodiment, and a stop disc 235 is installed at the right end of the limiting connecting pipe 234. One end of the first spring 236 abuts against the stop disc 235, and the other end abuts against the limiting plate 238. Further, the limiting plate 238 in this embodiment is specifically a disc-shaped structure.

[0075] In this embodiment, as Figure 5 and Figure 6 shown, the housing includes an upper housing 20 and a lower housing 21. The sealing film adhesive storage cavity 205 is provided in the upper housing 20, the sealing film adhesive conveying pipe 22 is installed in the lower housing 21, and the output end of the sealing film adhesive conveying pipe 22 passes out from the lower end of the lower housing 21. In this embodiment, the housing includes an upper housing 20 and a lower housing 21, which facilitates the installation of the conveying pipe, the first one-way valve 223 and the second one-way valve 225 in the lower housing 21. Further, the lower housing 21 in this embodiment is detachably installed at the lower end of the upper housing 20.

[0076] An embodiment of the present invention, asFigure 7 and Figure 8 As shown in Figure 8 , the cover glass automatic loading device 3 includes: a main body 30, a cover glass storage cavity 302 for storing cover glasses 36 is provided inside the main body 30, and a cover glass pushing channel 304 for sequentially passing single cover glasses 36 is further provided inside the main body 30. One end of the cover glass pushing channel 304 communicates with the cover glass storage cavity 302, and the other end extends out of the main body 30; a cover glass pushing device 31 for pushing the cover glasses 36 stored in the cover glass storage cavity 302 out from the cover glass pushing channel 304. The cover glass pushing device 31 includes a cover glass pushing plate 313 and a driving mechanism for driving the cover glass pushing plate 313 to move linearly. One end of the cover glass pushing plate 313 is connected to the driving mechanism, and the other end can extend into and withdraw from the cover glass pushing channel 304 and the cover glass storage cavity 302 under the drive of the driving mechanism; a cover glass pressing device 32 for pressing the cover glasses 36 stored in the cover glass storage cavity 302 to flatten the cover glasses 36 and make multiple cover glasses 36 close to each other. A pressing rod 324 is provided on the cover glass pressing device 32, and the pressing rod 324 can extend into the cover glass storage cavity 302.

[0077] In this embodiment, as Figure 7 and Figure 8 shown, by providing a cover glass storage cavity 302 inside the main body 30, it is convenient to store cover glasses 36 inside the main body 30; by providing a cover glass pushing device 31 to push the cover glasses 36 stored in the cover glass storage cavity 302 out from the cover glass pushing channel 304. The cover glass pushing device 31 includes a cover glass pushing plate 313 and a driving mechanism for driving the cover glass pushing plate 313 to move linearly. Under the drive of the driving mechanism, the cover glass pushing plate 313 can sequentially push the cover glasses 36 stored in the cover glass storage cavity 302 out, so as to facilitate pushing the cover glasses 36 out from the cover glass pushing channel 304 and placing the cover glasses 36 on the sealing glue of the tissue section, which is beneficial to avoiding the safety hazard of scratching the operator when the operator picks up the cover glass 36. In addition, by providing a cover glass pressing device 32 for pressing the cover glasses 36 stored in the cover glass storage cavity 302 to flatten the cover glasses 36 and make multiple cover glasses 36 close to each other, it is beneficial for multiple cover glasses 36 to be close to each other and ensure that only one cover glass 36 is pushed out during the process of the cover glass pushing plate 313 pushing the cover glass 36 once, and avoid the chaos of the cover glasses 36 placed in the cover glass storage cavity 302 from affecting the smoothness of pushing. Further, after the cover glass pushing plate 313 withdraws from the cover glass storage cavity 302, the cover glasses 36 stored in the cover glass storage cavity 302 move downward under the pressure of the cover glass pressing device 32, which is convenient for the cover glass pushing plate 313 to push out the next cover glass 36.

[0078] In this embodiment, as Figure 7 and Figure 8As shown, for the convenience of installing and fixing the cover glass automatic loading device 3, in this embodiment, a connection structure 35 is provided on one side of the main body 30, and the connection structure 35 is specifically connected to the upper end of the rear side of the main body 30. The connection structure 35 in this embodiment includes a horizontal connecting plate one 351, a vertical connecting plate 352, and a horizontal connecting plate two 353. One end of the horizontal connecting plate one 351 is horizontally and fixedly connected to the rear side of the main body 30, the vertical connecting plate 352 is vertically and fixedly connected to the upper side of the horizontal connecting plate one 351, and the horizontal connecting plate two 353 is horizontally connected to the upper end of the vertical connecting plate 352; the horizontal connecting plate two 353 can be fixed to other mechanisms to fixedly install the cover glass automatic loading device 3; further, the connection structure 35 in this embodiment can also be other structures, and the cover glass automatic loading device 3 can also be fixedly connected to other mechanisms in other ways.

[0079] In this embodiment, as Figure 7 and Figure 8 shown, in order to better push the cover glass 36 onto the sealing glue of the tissue section on the glass slide, in this embodiment, a cover glass delivery nozzle 303 is provided in the cover glass pushing channel 304, and the cover glass delivery nozzle 303 protrudes from the main body 30.

[0080] An embodiment of the present invention, as Figure 7 and Figure 8 shown, the cover glass pushing channel 304 is horizontally arranged and flush with the bottom of the cover glass storage cavity 302. A through groove for fitting the cover glass pushing plate 313 is provided on the main body 30 opposite to the cover glass pushing channel 304. The cover glass pushing plate 313 is horizontally arranged and one end of it can pass through the through groove and extend into the cover glass storage cavity 302 and the cover glass pushing channel 304. In this embodiment, the cover glass pushing channel 304 is horizontally arranged and flush with the bottom of the cover glass storage cavity 302. After the cover glass pushing plate 313 withdraws from the cover glass storage cavity 302, the cover glass 36 stored in the cover glass storage cavity 302 moves downward under the pressure of the cover glass pressing device 32, so that the cover glass 36 at the bottom is flush with the cover glass pushing channel 304, which is convenient for the cover glass pushing plate 313 to be pushed out of the main body 30 under the drive of the drive mechanism.

[0081] In this embodiment, the drive mechanism is an electric push rod two 311, and the cover glass pushing plate 313 is connected to the push rod 312 of the electric push rod two 311. In this embodiment, the electric push rod two 311 is used as the drive mechanism, which has a simple structure and is conducive to reliably driving the cover glass pushing plate 313 to extend into and withdraw from the cover glass storage cavity 302 and the cover glass pushing channel 304 to automatically push out the cover glass 36. Further, in order to protect the push rod 312 on the electric push rod two 311 in this embodiment, a protective cover 306 is provided at the rear end of the main body 30, and the protective cover 306 covers the push rod 312 on the electric push rod two 311.

[0082] An embodiment of the present invention, as Figure 7 and Figure 8 shown, the cover glass pressing device 32 includes: a support base, vertically and slidably mounted on the main body 30 and extending upward, a pressing rod 324 vertically and slidably mounted on the support base and located directly above the cover glass storage cavity 302, the upper end of the pressing rod 324 passing through the support base, and the lower end being able to extend into the cover glass storage cavity 302; a second spring 34, sleeved on the pressing rod 324, a stop plate 325 provided at the upper end of the pressing rod 324, a pressing plate 326 provided at the lower end of the pressing rod 324, the upper end of the second spring 34 abutted against the lower side of the support base, and the lower end of the second spring 34 abutted against the upper side of the pressing plate 326; a locking member for locking the support base and the main body 30 to fix the support base at different height positions, so that the second spring 34 mounted on the pressing rod 324 generates elastic deformation to press the cover glass 36 stored in the cover glass storage cavity 302.

[0083] In this embodiment, as Figure 7 and Figure 8 shown, the support base is vertically and slidably mounted on the main body 30, the pressing rod 324 is vertically and slidably mounted on the support base and located directly above the cover glass storage cavity 302, the upper end of the pressing rod 324 passes through the support base, and the lower end can extend into the cover glass storage cavity 302, and the support base and the main body 30 are locked by a locking member to fix the support base at different height positions, which is convenient for sliding the support base upward or adding the cover glass 36 into the cover glass storage cavity 302 after removing the support base; in addition, a second spring 34 is sleeved on the pressing rod 324, and by adjusting the fixed height of the support base in the vertical direction, the pressing degree of the second spring 34 on the cover glass 36 stored in the cover glass storage cavity 302 is adjusted, so that the pressing degree of the second spring 34 on the cover glass 36 is appropriate, which is convenient for the cover glass push plate 313 to push the cover glass 36 in the cover glass storage cavity 302 out, and avoids the cover glass 36 from being broken due to excessive pressure of the second spring 34 on the slide glass. In this embodiment, the locking member for locking the support base and the main body 30 is the fourth locking member 33, and the fourth locking member 33 is a tightening bolt.

[0084] In this embodiment, as Figures 1 to 4 shown, the support base includes a support sliding plate 321, a limit guide rail 322 and a horizontal support plate 323, the support sliding plate 321 is slidably mounted on the right side surface of the main body 30, a limit guide rail 322 is provided on the left side surface of the support sliding plate 321, the limit guide rail 322 has a T-shaped structure, and a sliding groove 305 for slidably connecting with the limit guide rail 322 in a matching manner is provided on the right side surface of the main body 30, the sliding groove 305 has a T-shaped structure, and the sliding groove 305 is opened downward from the upper part of the main body 30. Further, in this embodiment, a horizontal support plate 323 is horizontally connected to the left side of the limit guide rail 322, and the upper end of the pressing rod 324 passes through the horizontal support plate 323.

[0085] An embodiment of the present invention, as Figures 1 to 4 shown, the automatic tissue section mounting device further includes: a suspension beam, the suspension beam includes a first suspension beam 15 and a second suspension beam 16, the first suspension beam 15 and the second suspension beam 16 are arranged in parallel, and both ends of the first suspension beam 15 and the second suspension beam 16 are slidably mounted on the left and right ends of the support frame 1, and can slide in the front-rear direction relative to the glass slide placement plate 6. A plurality of automatic mounting glue dispensing devices 2 are spacedly installed on the first suspension beam 15, and a plurality of automatic cover glass placing devices 3 are spacedly installed on the second suspension beam 16. In this embodiment, a plurality of glass slide mounting grooves 60 for mounting multiple glass slides with tissue sections are spacedly provided on the glass slide placement plate 6. It should be noted that the glass slides and tissue sections placed on the glass slide placement plate 6 in this embodiment are not shown in the figure.

[0086] In this embodiment, as Figures 1 to 4 shown, by providing the first suspension beam 15 and the second suspension beam 16, and the first suspension beam 15 and the second suspension beam 16 are slidably mounted on the support frame 1, it is convenient to slide the first suspension beam 15 and the second suspension beam 16 in the front-rear direction to adjust the position of the suspension beam, and it is convenient to adjust the positions of the automatic mounting glue dispensing device 2 and the automatic cover glass placing device 3 in the front-rear direction.

[0087] The first suspension beam 15 and the second suspension beam 16 are provided with a plurality of installation openings for installing the cover slip glue automatic dispensing device 2 at intervals, and the installation openings are horizontally opened along the width direction of the first suspension beam 15 and the second suspension beam 16. In addition, in order to facilitate the installation of the cover slip glue automatic dispensing device 2 in this embodiment, a vertical connecting rod 201 is provided on the cover slip glue automatic dispensing device 2. The lower end of the vertical connecting rod 201 is fixedly connected to the upper shell 20 of the cover slip glue automatic dispensing device 2, and the upper end of the vertical connecting rod 201 extends vertically upward to form an extension end; and a horizontal connecting plate 203 is connected to the extension end of the vertical connecting rod 201. One end of the horizontal connecting plate 203 is connected to the upper end of the vertical connecting rod 201, and the other end extends horizontally to form a free end. The shape of the free end of the horizontal connecting plate 203 is adapted to the installation opening, and the free end of the horizontal connecting plate 203 is inserted into the installation opening in a matching manner. Further, in order to facilitate the fixation of the cover slip glue automatic dispensing device 2, in this embodiment, a locking member 4 is used to lock the cover slip glue automatic dispensing device 2, and a first threaded hole is provided on the upper side surfaces of the first suspension beam 15 and the second suspension beam 16. The first threaded hole communicates with the installation opening. The locking member 4 in this embodiment is a locking bolt. Further, a locking hole 202 corresponding to the first threaded hole is provided on the horizontal connecting plate 203. By tightening the locking member 4, the locking member 4 is threadedly connected to the first threaded hole and extends into the locking hole 202, and the cover slip glue automatic dispensing device 2 is fixed on the first suspension beam 15 and the second suspension beam 16. It should be noted that the cover slip glue automatic dispensing device 2 in this embodiment can also be fixedly connected to the first suspension beam 15 and the second suspension beam 16 in other ways, which will not be elaborated here.

[0088] An embodiment of the present invention, as Figures 1 to 4 shown, the support frame 1 includes: a bottom support plate 10; a plurality of vertical support rods 11, which are vertically connected to the rear end of the bottom support plate 10 and extend upward to form an extension end; a cross beam 12, which is connected to the extension ends of the plurality of vertical support rods 11; two support longitudinal beams 13, which are connected to the left and right ends of the cross beam 12 and extend forward to form an extension end, and both ends of the suspension beam are slidably installed on the support longitudinal beams 13; a placement plate mounting seat 17, which is located in the front part of the vertical support rods 11, and the slide glass placement plate 6 is detachably installed on the placement plate mounting seat 17.

[0089] In this embodiment, as Figures 1 to 4 shown, the support frame 1 includes two support longitudinal beams 13 connected to the left and right ends of the cross beam 12, which facilitates the sliding installation of the suspension beam and facilitates the longitudinal sliding of the suspension beam; in addition, the support frame 1 further includes a placement plate mounting seat 17, which facilitates the installation of the slide glass placement plate 6 below the suspension beam and is conducive to the cover slip glue automatic dispensing device 2 installed on the suspension beam to drip glue on the tissue section, so as to facilitate the placement of the cover glass 36 on the tissue section for cover slipping.

[0090] In this embodiment, as Figures 1 to 4 shown, the placement plate mounting seat 17 includes a bottom plate 171 and support rods 172 vertically connected to the bottom plate 171. There are multiple support rods 172, and a placement plate mounting plate 173 is installed at the upper ends of the multiple support rods 172. The slide glass placement plate 6 is installed on the placement plate mounting plate 173.

[0091] In this embodiment, as Figures 1 to 4 shown, a slide rail 131 is provided on the upper side surface of the support longitudinal beam 13. A sliding mounting seat 14 is slidably mounted on the slide rail 131. The two ends of the suspension beam are respectively installed on the sliding mounting seat 14. Further, in this embodiment, the sliding mounting seat 14 is provided with mounting holes for adaptively mounting the suspension beam, and the two ends of the suspension beam are respectively inserted into the mounting holes in an adaptive manner. In addition, a second locking member 5 is used to lock the suspension beam on the sliding mounting seat 14. And a second threaded hole communicating with the mounting hole is provided on the upper side surface of the sliding mounting seat 14. The second locking member 5 is threadedly connected in the second threaded hole and extends into the mounting hole. The second locking member 5 is a locking bolt. Further, the lower end of the sliding mounting seat 14 in this embodiment is a guide chute, and the guide chute is slidably connected to the slide rail 131 in an adaptive manner. In order to lock the sliding mounting seat 14 at different positions on the support longitudinal beam 13 in this embodiment, a third threaded hole communicating with the mounting hole is provided on the left or right side surface of the sliding mounting seat 14, and the sliding mounting seat 14 and the slide rail 131 are threadedly connected through a third locking member 7. The third locking member 7 is connected to one side surface of the sliding mounting seat 14 and extends into the guide chute. By tightening the third locking member 7, the third locking member 7 presses the slide rail 131 to lock the sliding mounting seat 14 on the support longitudinal beam 13. It should be noted that the telescopic amount of the first electric push rod 8 in this embodiment can be appropriately set according to the displacement that the piston needs to move and the distance between the first suspension beam 15 and the first electric push rod 8.

[0092] Specifically, in this embodiment, a plurality of automatic mounting glue dropping devices 2 for dropping a quantified mounting glue onto tissue sections placed on a glass slide are provided on a support frame 1. The automatic mounting glue dropping devices are electrically connected to a microprocessor, facilitating the dropping of a quantified mounting glue onto multiple tissue sections, which is conducive to reducing the influence of human factors on the dropped mounting glue, accurately dropping a certain amount of mounting glue, avoiding excessive or insufficient dropping of the mounting glue, and improving the quality of mounting. Additionally, a plurality of automatic cover glass placing devices 3 for placing a cover glass 36 on tissue sections placed on a glass slide after the quantified mounting glue has been dropped are provided. The automatic cover glass placing devices 3 are electrically connected to the microprocessor. By using the automatic cover glass placing devices 3 to place the cover glass 36 on the mounting glue on the tissue sections, it is conducive to avoiding the potential safety hazard of the operator being scratched when picking up the cover glass 36. Thus, the automatic tissue section mounting device in the present invention can automatically drop a quantified mounting glue and automatically place the cover glass 36 on the tissue sections, avoiding excessive or insufficient dropping of the mounting glue and improving the quality and efficiency of mounting.

[0093] In addition, except for the technical solutions disclosed in the embodiments of the present disclosure, for the first one-way valve 223, the second one-way valve 225, the electric push rod, the microprocessor, and their working principles in the present invention, reference can be made to the conventional technical solutions in this technical field. However, these conventional technical solutions are not the focus of the present invention, and thus will not be described in detail herein.

[0094] In the present invention, the term "a plurality of" refers to two or more, unless otherwise clearly defined. Terms such as "mount", "connect", "join", "fix", etc. should be understood in a broad sense. For example, "connect" can be a fixed connection, a detachable connection, or an integral connection; "join" can be a direct join or an indirect join through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0095] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by terms such as "upper", "lower", "front", "rear", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or unit referred to must have a specific direction, be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation to the present application.

[0096] In the description of this specification, the descriptions of the terms "one embodiment", "some embodiments", "specific embodiments", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or instance. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0097] The above are only the preferred embodiments of the present application and are not intended to limit the present application. For those skilled in the art, the present application may have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included within the protection scope of the present application.

Claims

1. An automatic tissue section cover-slipping device, characterized in that, it includes: A support frame, on which a slide placing plate for placing a slide with a tissue section is provided; An automatic mounting glue dropping device for dropping a quantitative amount of mounting glue on the tissue section placed on the slide. There are multiple automatic mounting glue dropping devices, and the multiple automatic mounting glue dropping devices are spaced and installed on the support frame and are located above the slide placing plate; An automatic cover glass placing device for covering a cover glass on the tissue section placed on the slide after dropping a quantitative amount of mounting glue. There are multiple automatic cover glass placing devices, and the multiple automatic cover glass placing devices are spaced and installed on the support frame and are located above the slide placing plate; A microprocessor, and the automatic mounting glue dropping device and the automatic cover glass placing device are respectively electrically connected to the microprocessor; The automatic mounting glue dropping device includes: A housing, inside which a mounting glue storage cavity for storing mounting glue is provided; A mounting glue delivery pipe, the two ends of the mounting glue delivery pipe are respectively an input end and an output end. The input end extends into the mounting glue storage cavity and is communicated with the mounting glue storage cavity, and the output end penetrates through the housing; A mounting glue suction and discharge device for sucking the mounting glue stored in the mounting glue storage cavity into the mounting glue delivery pipe and discharging the mounting glue sucked into the mounting glue delivery pipe from the mounting glue delivery pipe. The mounting glue suction and discharge device is connected to the mounting glue delivery pipe and is communicated with the mounting glue delivery pipe, and the mounting glue suction and discharge device is electrically connected to the microprocessor; A first one-way valve, connected to the mounting glue delivery pipe and located between the input end and the connection of the mounting glue suction and discharge device and the mounting glue delivery pipe. The one-way conduction direction of the first one-way valve is from the input end to the connection of the mounting glue suction and discharge device and the mounting glue delivery pipe; A second one-way valve, connected to the mounting glue delivery pipe and located between the output end and the connection of the mounting glue suction and discharge device and the mounting glue delivery pipe. The one-way conduction direction of the second one-way valve is from the connection of the mounting glue suction and discharge device and the mounting glue delivery pipe to the output end; the first one-way valve and the second one-way valve are alternately conducted and closed under the action of the mounting glue suction and discharge device, and a quantitative amount of mounting glue is output from the output end of the mounting glue delivery pipe after completing an alternating process of conduction and closing.

2. The automatic tissue section cover-slipping device according to claim 1, characterized in that, The slide placing plate is linearly slidably installed on the support frame and can slide to directly below the automatic mounting glue dropping device and the automatic cover glass placing device.

3. The automatic tissue section cover-slipping device according to claim 1, characterized in that, The cover slip glue suction and discharge device includes a suction and discharge pipe and a drive mechanism for enabling the suction and discharge pipe to suck and discharge the cover slip glue. One end of the suction and discharge pipe is connected to and communicates with the cover slip glue delivery pipe. The drive mechanism drives the suction and discharge pipe to suck in and output the cover slip glue, and the drive mechanism is electrically connected to the microprocessor.

4. The automatic tissue section cover slipping device according to claim 3, wherein, a cover slip glue suction and discharge cavity is provided in the suction and discharge pipe, and the volume of the cover slip glue suction and discharge cavity is equal to the volume of the cover slip glue required for one cover slipping or the volume of the cover slip glue suction and discharge cavity in several multiples is equal to the volume of the cover slip glue required for one cover slipping; the drive mechanism includes: a piston, which is slidably installed in the cover slip glue suction and discharge cavity of the suction and discharge pipe in a matching manner; a push-pull rod, one end of which is connected to the piston, and the other end extends out of the housing to form an extended end; an electric push rod, which is fixedly connected to the support frame. An expansion rod is provided on the electric push rod, and the expansion rod is fixedly connected to the extended end of the push-pull rod. The electric push rod is electrically connected to the microprocessor.

5. The automatic tissue section cover slipping device according to claim 4, wherein, a limiting plate is provided on the push-pull rod, and a first spring is installed between the limiting plate and the cover slip glue delivery pipe. The first spring is sleeved on the push-pull rod, and one end of the first spring abuts against the limiting plate, and the other end abuts against the suction and discharge pipe or the cover slip glue delivery pipe.

6. The automatic tissue section cover slipping device according to claim 1, wherein, the cover slip automatic placing device includes: a body, a cover slip storage cavity for storing cover slips is provided in the body, and a cover slip pushing channel for sequentially passing a single cover slip is further provided in the body. One end of the cover slip pushing channel communicates with the cover slip storage cavity, and the other end extends out of the body; a cover slip pushing device for pushing the cover slips stored in the cover slip storage cavity out of the cover slip pushing channel. The cover slip pushing device includes a cover slip pushing plate and a drive mechanism for driving the cover slip pushing plate to move linearly. One end of the cover slip pushing plate is connected to the drive mechanism, and the other end can be driven by the drive mechanism to extend into and withdraw from the cover slip pushing channel and the cover slip storage cavity; a cover slip pressing device for pressing the cover slips stored in the cover slip storage cavity to flatten the cover slips and make multiple cover slips close to each other. A pressing rod is provided on the cover slip pressing device, and the pressing rod can extend into the cover slip storage cavity.

7. The automatic tissue section cover slipping device according to claim 6, wherein, the cover slip pressing device includes: a support seat, which is vertically slidably installed on the body and extends upward. The pressing rod is vertically slidably installed on the support seat and is located directly above the cover slip storage cavity. The upper end of the pressing rod passes through the support seat, and the lower end can extend into the cover slip storage cavity; The second spring is sleeved on the pressing rod. A stop baffle is provided at the upper end of the pressing rod, and a pressing plate is provided at the lower end of the pressing rod. The upper end of the second spring abuts against the lower side of the support seat, and the lower end of the second spring abuts against the upper side of the pressing plate; A locking member is used to lock the support seat and the main body to fix the support seat at different height positions, so that the second spring installed on the pressing rod generates elastic deformation to press the cover glass stored in the cover glass storage cavity.

8. The automatic tissue section covering device according to any one of claims 1 to 7, characterized in that, it further comprises: A suspension beam, which includes a first suspension beam and a second suspension beam. The first suspension beam and the second suspension beam are arranged in parallel. The two ends of the first suspension beam and the second suspension beam are respectively slidably installed on the left and right ends of the support frame, and can slide in the front-rear direction relative to the slide glass placement plate. A plurality of the cover slip glue automatic dispensing devices are spacedly installed on the first suspension beam, and a plurality of the cover glass automatic placement devices are spacedly installed on the second suspension beam.

9. The automatic tissue section covering device according to claim 8, characterized in that, the support frame includes: A bottom support plate; Vertical support rods, there are multiple vertical support rods vertically connected to the rear end of the bottom support plate and extending upward to form an extended end; A cross beam, connected to the extended ends of the multiple vertical support rods; Support longitudinal beams, there are two support longitudinal beams connected to the left and right ends of the cross beam and extending forward to form an extended end, and the two ends of the suspension beam are slidably installed on the support longitudinal beams; A placement plate mounting seat, located at the front of the vertical support rod, and the slide glass placement plate is detachably installed on the placement plate mounting seat.

Citation Information

Patent Citations

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