A device for making a small animal craniocerebral explosion injury model

Abstract

The invention discloses a device for making a small animal craniocerebral explosion injury model, which specifically relates to the field of medical research technology, including a base plate, a shielding box is provided inside the base plate, and a quick adjustment component is provided inside the shielding box; the quick adjustment component includes bases arranged at both ends of the base plate, and two guide rods are arranged between the two bases, a base is fixedly provided at the center of the upper surface of the base plate, a swing plate is provided above the base plate, the two guide rods are respectively slidably matched with a first slide seat and a second slide seat at both ends along the lateral direction, the upper surfaces of the first slide seat and the second slide seat are respectively fixedly connected with a first connecting rod and a second connecting rod at one end close to the base plate, the top end of the base plate is rotatably matched with a rotating seat, and a steel rod is provided at the top end of the rotating seat. The small animal craniocerebral explosion injury model has good stability, reliability and repeatability during the experiment, and the explosion injury model can be flexibly and accurately adjusted with high precision.

Description

Technical Field

[0001] The invention relates to the technical field of medical research, and in particular to a device for making a small animal craniocerebral explosion injury model. Background Art

[0002] There are many factors causing injuries caused by explosive weapons, such as multiple injuries, injuries to multiple parts of the body, combined injuries, and severe injuries. Therefore, strengthening the research on the characteristics and treatment of injuries caused by explosive weapons, especially the treatment of craniocerebral blast injuries, has important practical significance. However, how to establish a stable animal model of craniocerebral blast injuries and enable it to survive long enough to continuously observe the pathological and physiological changes after the injury and explore treatment methods is a thorny problem.

[0003] The existing small animal craniocerebral blast injury models have poor stability and reliability during the experiment, and the blast injury models cannot be flexibly and accurately adjusted, resulting in low repeatability of the blast injury models, and it is impossible to make good use of shock waves to create a small animal craniocerebral blast injury model with high accuracy;

[0004] To this end, we proposed a device for making a craniocerebral blast injury model in small animals. Summary of the invention

[0005] To this end, the present invention provides a device for making a small animal craniocerebral blast injury model, aiming to solve the problems that the existing small animal craniocerebral blast injury model has poor stability and reliability during the experiment, and the blast injury model cannot be flexibly and accurately adjusted, resulting in low repeatability of the blast injury model, and it is impossible to make good use of shock waves to create a small animal craniocerebral blast injury model with high accuracy.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] According to a first aspect of the present invention, a device for making a small animal craniocerebral blast injury model comprises a base plate, a shielding box is provided inside the base plate, a box door is hingedly connected to an outer side wall of one side of the shielding box, and a quick adjustment component is provided inside the shielding box, a horizontal axis is fixedly installed on the inner top wall of the shielding box, and a movable shielding plate is sleeved on the outer surface of the horizontal axis, and the movable shielding plate is connected to the fixed component;

[0008] The quick adjustment assembly includes bases arranged at both ends of the base plate, and two guide rods are arranged between the two bases, and a scale line is arranged at the top end of one of the guide rods, a base is fixedly arranged at the center of the upper surface of the base plate, a swing plate is arranged above the base plate, and one end of the swing plate is connected to the driving assembly, and the two guide rods are respectively slidably matched with a first slide seat and a second slide seat at both ends along the lateral direction, and the upper surfaces of the first slide seat and the second slide seat are respectively fixedly connected with a first connecting rod and a second connecting rod at one end close to the base, and the first connecting rod and the second connecting rod are respectively hinged to the two ends of the swing plate along the lateral direction;

[0009] A height adjustment component is provided at the top of the second slide seat, and a mounting seat is slidably matched on one side of the height adjustment component, and a pressure detector is clamped inside the mounting seat, and the pressure detector is connected to a data acquisition system. The top of the base is rotatably matched with a rotating seat, and a steel rod is provided on the top of the rotating seat, and a paper detonator is fixedly installed on one side of the steel rod.

[0010] The fixing assembly includes a second vertical plate bolted to the first slide seat, and a sleeve is inserted into the interior of the second vertical plate along the horizontal direction, and a pin is provided on one side of the sleeve, and the sleeve is rotated with a turntable through the pin, and a first through hole is opened on the outer wall of the turntable, and a plurality of second through holes of different sizes are opened on the outer wall of the sleeve close to the turntable.

[0011] Furthermore, the movable shielding plate is fixedly connected to the outer side wall of the second vertical plate by bolts.

[0012] Furthermore, the bottom ends of the first slide seat and the second slide seat are each provided with a sleeve seat which is respectively sleeved with the two guide rods.

[0013] Furthermore, the driving assembly includes a main shaft plugged into the swing plate, and one end of the main shaft located at the bottom of the base plate is connected to a bevel gear set.

[0014] Furthermore, a rotating shaft is inserted into the driving end of the bevel gear set, and a first hand wheel is fixedly connected to the end of the rotating shaft.

[0015] Furthermore, a bottom plate is provided directly below the base plate, and shock-absorbing seats are fixedly connected between the four corners of the bottom of the base plate and the bottom plate.

[0016] Furthermore, two clamping seats are provided inside the mounting seat, and springs are fixedly installed between the two clamping seats and two inner side walls of the mounting seat along the lateral direction.

[0017] Furthermore, the height adjustment assembly includes a first vertical plate fixed to the second sliding seat with bolts, and a fixing seat is fixedly installed on an outer side wall of one side of the first vertical plate.

[0018] Furthermore, a lead screw is provided inside the fixing seat in a vertical direction, and a second hand wheel is fixedly mounted on one end of the lead screw located at the top of the fixing seat.

[0019] Furthermore, a nut is meshed on the outer surface of the lead screw, and a third sliding seat is sleeved on the outer surface of the nut, and one side of the mounting seat is welded to the third sliding seat.

[0020] The present invention has the following advantages:

[0021] 1. The quick-adjusting assembly is used to adjust the position of the first slide and the second slide from the base, so that the position of the paper detonator from the mouse head and the pressure detector can be adjusted according to the experimental needs. The scale lines on the guide rod indicate the distance between the two and the paper detonator to achieve the adjustment of model factors. The small animal craniocerebral explosion injury model has good stability, reliability and repeatability during the experiment, and the explosion injury model can be flexibly and accurately adjusted with high precision.

[0022] 2. Through the height adjustment component, the height adjustment of the mounting base and the internal pressure detector can be flexibly realized, so that the pressure detector, the paper detonator and the head of the mouse are at the same level, and the explosion injury model can be flexibly and accurately adjusted with high precision. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the implementation methods of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the implementation methods or the description of the prior art. Obviously, the drawings in the following description are only exemplary, and for ordinary technicians in this field, other implementation drawings can be derived from the provided drawings without creative work.

[0024] The structures, proportions, sizes, etc. illustrated in this specification are only used to match the contents disclosed in the specification so as to facilitate understanding and reading by persons familiar with the technology. They are not used to limit the conditions under which the present invention can be implemented, and therefore have no substantial technical significance. Any structural modification, change in proportion or adjustment of size shall still fall within the scope of the technical contents disclosed in the present invention without affecting the effects and purposes that can be achieved by the present invention.

[0025] Figure 1 A schematic diagram of the internal structure provided by the present invention;

[0026] Figure 2 The front view provided by the present invention;

[0027] Figure 3 The present invention provides Figure 1 A magnified view of the structure of the middle A part;

[0028] Figure 4 A top view of the quick-adjusting assembly provided by the present invention;

[0029] Figure 5 A three-dimensional diagram of a fixing assembly provided by the present invention;

[0030] Figure 6 A schematic diagram of the internal structure of the height adjustment assembly provided by the present invention;

[0031] Figure 7 A side view of the mounting base provided by the present invention;

[0032] In the figure: 1, substrate; 2, shielding box; 3, box door; 4, base; 5, guide rod; 6, first slide; 7, second slide; 8, height adjustment assembly; 801, first vertical plate; 802, fixed seat; 803, lead screw; 804, nut; 805, third slide; 806, second hand wheel; 9, fixed assembly; 901, second vertical plate; 902, sleeve; 903, pin; 904, turntable; 905, first through hole; 906, The second through hole; 10, movable shielding plate; 11, horizontal axis; 12, first connecting rod; 13, second connecting rod; 14, swing plate; 15, rotating seat; 16, steel rod; 17, paper detonator; 18, main shaft; 19, bevel gear set; 20, rotating shaft; 21, base; 22, first hand wheel; 23, scale line; 24, mounting seat; 25, pressure detector; 26, holder; 27, spring; 28, bottom plate; 29, shock-absorbing seat; 30, sleeve seat. DETAILED DESCRIPTION

[0033] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] Refer to the instruction manual Figure 1-5 The device for making a small animal craniocerebral explosion injury model of the embodiment includes a base plate 1, a shielding box 2 is arranged inside the base plate 1, a box door 3 is hinged on one side outer wall of the shielding box 2, and a quick adjustment component is arranged inside the shielding box 2, a horizontal axis 11 is fixedly installed on the inner top wall of the shielding box 2, and a movable shielding plate 10 is sleeved on the outer surface of the horizontal axis 11, and the movable shielding plate 10 is connected to the fixed component 9;

[0035] The quick adjustment assembly includes a base 4 arranged at both ends of the base plate 1, and two guide rods 5 are arranged between the two bases 4, and a scale line 23 is arranged on the top of one of the guide rods 5. A base 21 is fixedly arranged at the center of the upper surface of the base plate 1, and a swing plate 14 is arranged above the base 21, and one end of the swing plate 14 is connected to the driving assembly. The two guide rods 5 are respectively slidably matched with a first slide 6 and a second slide 7 at both ends along the lateral direction, and the first slide 6 and the second slide 7 are respectively fixedly connected with a first connecting rod 12 and a second connecting rod 13 at one end of the upper surface close to the base 21, and the first connecting rod 12 and the second connecting rod 13 are respectively hinged to the two ends of the swing plate 14 along the lateral direction;

[0036] A height adjustment assembly 8 is provided at the top of the second slide 7, and a mounting seat 24 is slidably fitted on one side of the height adjustment assembly 8, and a pressure detector 25 is clamped inside the mounting seat 24, and the pressure detector 25 is connected to a data acquisition system. A rotating seat 15 is rotatably fitted at the top of the base 21, and a steel rod 16 is provided at the top of the rotating seat 15, and a paper detonator 17 is fixedly installed on one side of the steel rod 16.

[0037] The fixing assembly 9 includes a second vertical plate 901 bolted to the first slide seat 6, and a sleeve 902 is inserted into the interior of the second vertical plate 901 along the horizontal direction, and a pin shaft 903 is provided on one side of the sleeve 902, and the sleeve 902 is rotatably engaged with a turntable 904 through the pin shaft 903, and a first through hole 905 is provided on the outer wall of the turntable 904, and a plurality of second through holes 906 of different sizes are provided on the outer wall of the sleeve 902 close to the turntable 904.

[0038] The movable shielding plate 10 is fixedly connected to the outer side wall of the second vertical plate 901 by bolts.

[0039] Furthermore, the bottom ends of the first slide 6 and the second slide 7 are both provided with sleeves 30 which are respectively sleeved with the two guide rods 5 .

[0040] Furthermore, the driving assembly includes a main shaft 18 plugged into the swing plate 14, and one end of the main shaft 18 located at the bottom of the base plate 1 is connected to a bevel gear set 19.

[0041] Furthermore, a rotating shaft 20 is inserted into the driving end of the bevel gear set 19 , and a first hand wheel 22 is fixedly connected to the end of the rotating shaft 20 .

[0042] The implementation scenario is as follows: first, a small animal used for the blast injury experiment, such as a mouse, is anesthetized by intraperitoneal injection of 1 ml of 1.5% sodium pentobarbital, and the limbs are tied to the four sides of the turntable 904 with plastic ropes, and another rope is hooked on the incisors and suspended on the top of the turntable 904, with the mouse standing with its back against the side wall of the turntable 904, and the head of the mouse is located at the first through hole 905, and the trunk below the foramen magnum and the mouth and face above the inner line connecting the eyes are fully protected, and at the same time, the turntable 904 is rotated to adjust the position of the mouse and the second through hole 906 on the sleeve 902, so that the second through holes 906 with different apertures overlap with the first through holes 905 in sequence;

[0043] Subsequently, the paper detonator 17 is fixed on the steel rod 16, and the pressure detector 25 is installed on the mounting seat 24, and it is ensured that the pressure detector 25 is at the same horizontal height as the paper detonator 17 and the head of the mouse. Then, according to the position of the paper detonator 17 from the head of the mouse required by the experiment, the first hand wheel 22 is rotated to make the rotating shaft 20 drive the bevel gear set 19 to rotate, so that the main shaft 18 connected to the real-time bevel gear set 19 rotates to drive the swing plate 14 to swing. Since the first connecting rod 12 and the second connecting rod 13 are respectively hinged at both ends of the top of the swing plate 14 in the horizontal direction, and the first connecting rod 12 and the second connecting rod 13 are respectively fixed to the second slide 7 and the first slide 6, and the second slide 7 and the first slide 6 are fixed and respectively slidably cooperate with the two groups of guide rods 5, when the swing plate 14 swings, the first connecting rod 12 and the second connecting rod 13 respectively push the second slide 7 and the first slide 6 to slide, and at the same time, the second slide 7 and The first slide 6 is kept at the same distance from the paper detonator 17 according to the scale line 23 on the guide rod 5, so as to stop the rotation of the first hand wheel 22 in time. The first slide 6 is connected to the fixed component 9, and the second vertical plate 901 of the fixed component 9 is fixed to the movable shielding plate 10. When the first slide 6 slides, the movable shielding plate 10 is driven to slide on the horizontal axis 11 to ensure the airtightness of the shielding box 2. After adjusting the distance, when the door 3 of the shielding box 2 is closed, the paper detonator 17 can be detonated, and the pressure detector 25 detects the pressure change, pressure peak and positive impulse of the explosion shock wave. The pressure detector 25 is connected to the wavebook / 516A data acquisition system through the signal conditioning module. After the paper detonator 17 is detonated, the shock wave overpressure is recorded by the data acquisition system, and the origin7.0 is used for filtering and analysis, so as to complete the production of the small animal craniocerebral explosion injury model;

[0044] The small animal craniocerebral blast injury model has good stability, reliability and repeatability during the experiment, and the blast injury model can be flexibly and accurately adjusted with high precision.

[0045] Refer to the instruction manual Figure 1 , 67. This embodiment is a device for making a small animal craniocerebral explosion injury model. A bottom plate 28 is provided directly below the base plate 1, and shock-absorbing seats 29 are fixedly connected between the four corners of the bottom of the base plate 1 and the bottom plate 28, so that the entire model has a good shock-absorbing effect and ensures the structural stability of the model.

[0046] Furthermore, two clamping seats 26 are provided inside the mounting seat 24 , and springs 27 are fixedly installed between the two clamping seats 26 and the inner side walls of the mounting seat 24 along the lateral direction to ensure the stability of the mounting structure of the pressure detector 25 .

[0047] Furthermore, the height adjustment assembly 8 includes a first vertical plate 801 fixed to the second slide seat 7 with bolts, and a fixing seat 802 is fixedly installed on an outer side wall of one side of the first vertical plate 801.

[0048] Furthermore, a lead screw 803 is provided inside the fixing seat 802 along the vertical direction, and a second hand wheel 806 is fixedly mounted on one end of the lead screw 803 located at the top of the fixing seat 802 .

[0049] Furthermore, a nut 804 is meshed on the outer surface of the lead screw 803 , and a third slide seat 805 is sleeved on the outer surface of the nut 804 , and one side of the mounting seat 24 is welded to the third slide seat 805 .

[0050] The specific implementation scenario is: through the height adjustment component 8, the pressure detector 25, the paper detonator 17 and the head of the mouse are located at the same horizontal height, and the second hand wheel 806 is turned to rotate the screw 803 inside the fixed seat 802, driving the nut 804 on its outer surface and the third slide 805 to slide thereon. The third slide 805 is fixed to the mounting seat 24, thereby driving the height adjustment of the mounting seat 24 and the pressure detector 25 installed inside. The explosion injury model can be flexibly and accurately adjusted with high precision. The pressure detector 25, the paper detonator 17 and the head of the mouse are located at the same horizontal height, which can be determined by a level, laser or manual wire measurement.

[0051] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A device for making a small animal craniocerebral explosion injury model, comprising a substrate (1), characterized in that: A shielding box (2) is provided inside the substrate (1), a box door (3) is hingedly connected to an outer side wall of one side of the shielding box (2), and a quick adjustment component is provided inside the shielding box (2), a transverse axis (11) is fixedly installed on the inner top wall of the shielding box (2), and a movable shielding plate (10) is sleeved on the outer surface of the transverse axis (11), and the movable shielding plate (10) is connected to the fixed component (9); The quick adjustment component comprises bases (4) arranged at both ends of the base plate (1), and two guide rods (5) are arranged between the two bases (4), and a scale line (23) is arranged on the top of one of the guide rods (5). A base (21) is fixedly arranged at the center of the upper surface of the base plate (1), and a swing plate (14) is arranged above the base (21), and one end of the swing plate (14) is connected to the driving component. The two guide rods (5) are respectively slidably matched with a first slide seat (6) and a second slide seat (7) at both ends along the lateral direction, and the upper surfaces of the first slide seat (6) and the second slide seat (7) are respectively fixedly connected with a first connecting rod (12) and a second connecting rod (13) at one end close to the base (21), and the first connecting rod (12) and the second connecting rod (13) are respectively hinged to the two ends of the swing plate (14) along the lateral direction; The top of the second slide seat (7) is provided with a height adjustment component (8), and a mounting seat (24) is slidably matched on one side of the height adjustment component (8), and a pressure detector (25) is clamped inside the mounting seat (24), and the pressure detector (25) is connected to a data acquisition system, and the top of the base (21) is rotatably matched with a rotating seat (15), and a steel rod (16) is provided on the top of the rotating seat (15), and a paper detonator (17) is fixedly installed on one side of the steel rod (16); The fixing assembly (9) comprises a second vertical plate (901) fixed with bolts to the first sliding seat (6), and a sleeve (902) is inserted into the interior of the second vertical plate (901) in a transverse direction, and a pin shaft (903) is provided on one side of the sleeve (902), and the sleeve (902) is rotatably matched with a rotating disk (904) through the pin shaft (903), and a first through hole (905) is provided on the outer side wall of the rotating disk (904), and a plurality of second through holes (906) of different sizes are provided on the outer side wall of the sleeve (902) close to the rotating disk (904); The driving assembly comprises a main shaft (18) plugged into the swing plate (14), and one end of the main shaft (18) located at the bottom of the base plate (1) is connected to a bevel gear set (19), a driving end of the bevel gear set (19) is plugged into a rotating shaft (20), and an end of the rotating shaft (20) is fixedly connected to a first hand wheel (22); A bottom plate (28) is provided directly below the base plate (1), and shock-absorbing seats (29) are fixedly connected between the bottom plate (28) and the four corners of the bottom of the base plate (1).

2. The device for making a small animal craniocerebral explosion injury model according to claim 1, characterized in that: The movable shielding plate (10) is fixedly connected to the outer side wall of the second vertical plate (901) by means of bolts.

3. The device for making a small animal craniocerebral explosion injury model according to claim 1, characterized in that: The bottom ends of the first slide seat (6) and the second slide seat (7) are both provided with sleeve seats (30) respectively sleeved with the two guide rods (5).

4. The device for making a small animal craniocerebral explosion injury model according to claim 1, characterized in that: Two clamping seats (26) are arranged inside the mounting seat (24), and springs (27) are fixedly installed between the two clamping seats (26) and the inner side walls of the mounting seat (24) along the transverse direction.

5. The device for making a small animal craniocerebral explosion injury model according to claim 1, characterized in that: The height adjustment assembly (8) comprises a first vertical plate (801) fixed to the second sliding seat (7) by bolts, and a fixing seat (802) is fixedly mounted on an outer side wall of one side of the first vertical plate (801).

6. The device for making a small animal craniocerebral explosion injury model according to claim 5, characterized in that: A lead screw (803) is provided inside the fixed seat (802) in a vertical direction, and a second hand wheel (806) is fixedly mounted on one end of the lead screw (803) located at the top of the fixed seat (802).

7. The device for making a small animal craniocerebral explosion injury model according to claim 6, characterized in that: The outer surface of the lead screw (803) is meshed with a nut (804), and the outer surface of the nut (804) is sleeved with a third slide seat (805), and one side of the mounting seat (24) is welded to the third slide seat (805).

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