A composition with synergistic whitening activity and application in whitening and lightening daily-use washing and care products

Abstract

This invention discloses a composition with synergistic whitening activity and its application in whitening and brightening daily chemical personal care products. β-Arbutin has a price advantage, but its whitening activity needs improvement. This invention provides a composition consisting of β-arbutin and turmeric ketone diol. In this composition, β-arbutin and turmeric ketone diol exhibit synergistic whitening activity. Combining turmeric ketone diol with β-arbutin significantly enhances the whitening activity of β-arbutin. Therefore, this composition can be used to prepare whitening and brightening daily chemical personal care products, such as facial cleansers, face creams, hand creams, lotions, and face masks.

Description

Technical Field

[0001] This invention belongs to the field of cosmetics and relates to cosmetics that whiten and brighten skin tone. Specifically, it relates to a composition with synergistic whitening activity and its application in whitening and brightening daily chemical washing and care products. Background Technology

[0002] Beauty is an eternal topic for humankind. There is a Chinese saying, "Fair skin covers a hundred flaws," and "skin whitening" has driven countless people crazy.

[0003] As early as the Shang Dynasty, there was a story of "King Zhou burning lead to make powder". With the development of science, the method of whitening has gradually transformed from "physical powder whitening" to "chemical bleaching" to "biological whitening". People's understanding of the whitening mechanism has made a qualitative leap. The whitening ingredient arbutin was discovered and then widely used.

[0004] Arbutin can be divided into α-arbutin and β-arbutin. α-arbutin and β-arbutin are actually two isomers of arbutin, differing only in optical rotation, but differing drastically in extraction difficulty, price, and efficacy. Currently, most arbutin on the market is β-arbutin, which is much cheaper than α-arbutin, but its whitening effect is also much weaker.

[0005] It is evident that β-arbutin has a price advantage, but its skin-whitening activity needs to be improved. Summary of the Invention

[0006] The present invention aims to overcome the shortcomings of the prior art and provide a composition with synergistic whitening activity and its application in whitening and brightening daily chemical care products. The composition consists of β-arbutin and turmeric oxalool.

[0007] The technical solution of this invention is as follows:

[0008] A composition comprising β-arbutin and turmeric oxalool.

[0009] Preferably, the mass ratio of β-arbutin to turmeric diol is 1:1.5.

[0010] The above composition is used as a tyrosinase inhibitor.

[0011] The above composition has the effect of whitening and brightening the skin.

[0012] The above composition is used in the preparation of whitening and brightening daily chemical personal care products.

[0013] Preferably, the daily chemical personal care products include facial cleanser, face cream, hand cream, lotion, face mask, etc.

[0014] Beneficial technical effects:

[0015] β-Arbutin has a price advantage, but its whitening activity needs improvement. This invention provides a composition consisting of β-arbutin and turmeric ketone diol. In this composition, β-arbutin and turmeric ketone diol exhibit synergistic whitening activity. Combining turmeric ketone diol with β-arbutin significantly enhances the whitening activity of β-arbutin. Therefore, this composition can be used to prepare whitening and brightening daily chemical care products, such as facial cleansers, face creams, hand creams, lotions, and face masks. Attached Figure Description

[0016] Figure 1 The inhibition rate of tyrosinase by different concentrations of compounds / compositions;

[0017] Figure 2 The gold standard q values ​​represent the inhibition rates of tyrosinase by the combined use of different concentrations of β-arbutin and turmeric oxalool. Detailed Implementation

[0018] The following detailed description of the substantive content of the present invention through specific embodiments should not be construed as limiting the scope of protection of the present invention.

[0019] I. Experimental Materials

[0020] The purity of β-arbutin and turmeric oxalool (CAS No.: 98644-24-7) is not less than 98%.

[0021] The water used in the experiment was Wahaha purified water, and all chemical reagents were conventional reagents.

[0022] II. Test Methods

[0023] Reference Method (Synthesis and Inhibition of Tyrosinase Activity of Cinnamic Acid-Coumarin Ester Analogs, Organic Chemistry, Chin. J. Org. Chem. 2020, 40) Determination of the inhibition rate of β-arbutin, turmeric oxalool and their combinations on tyrosinase:

[0024] β-Arbutin, Curcumonediol, and their combinations were dissolved in DMSO and diluted to different concentrations. 130 μL of phosphate buffer (50 mM, pH 6.8), 10 μL of tyrosinase solution (final concentration 33.3 U / mL), and 10 μL of the test compound / composition were mixed, followed by the addition of 50 μL of L-Dopa (final concentration 0.5 mM). The OD value was measured at 490 nm after 10 min. A control group was also included, with 10 μL of solvent added instead of the drug solution. Five replicates were performed for each reaction, and the mean was calculated. The inhibition rate of different concentrations of the test compound / composition on tyrosinase was calculated using the following formula:

[0025] Inhibition rate (%) = (OD control - OD drug) / OD control × 100%.

[0026] III. Test Results

[0027] The inhibition rates of different concentrations of compounds / combinations on tyrosinase are shown in Table 1 and... Figure 1 As shown.

[0028] Table 1. Inhibition rate of tyrosinase at different concentrations of compounds / combinations

[0029]

[0030] Following the method described in the literature (Effects of artesunate on proliferation and apoptosis of human hepatocellular carcinoma HepG2 cells and its anti-hepatocellular carcinoma effect in combination with chemotherapy drugs, Chinese Journal of Pathophysiology, 2012, 28), the effect of the combined use of β-arbutin and turmeric diol was determined by calculating the Jin Zhengjun q-value based on the inhibition rate: q = E a+b / (E a +E b -E a ×E b E a and E b The inhibition rates of β-arbutin and turmeric diol alone were E, respectively. a+b The denominator represents the inhibition rate of combined medication. In the formula, the numerator represents the "measured combined effect", the denominator is the "expected combined effect", and the q value is the ratio of the two. q < 0.85 indicates an antagonistic effect, 0.85 ≤ q < 1.15 indicates an additive effect, and q ≥ 1.15 indicates a synergistic effect.

[0031] The average q values ​​of the inhibition rate of tyrosinase by different concentrations of β-arbutin combined with turmeric oxalool are shown in Table 2. Figure 2 As shown, the q values ​​of Jin Zhengjun were all greater than 1.15, indicating that β-arbutin and turmeric ketone diol synergistically inhibit the activity of tyrosinase.

[0032] Table 2. Golden mean q values ​​of the inhibition rate of tyrosinase by different concentrations of β-arbutin combined with curcuminone diol.

[0033] concentration mass ratio Kim Jong-kyun's q value β-Arbutin + Curcumone Diol (0.2 mg / mL + 0.3 mg / mL) 1:1.5 1.29 β-Arbutin + Curcumone Diol (0.4 mg / mL + 0.6 mg / mL) 1:1.5 1.32 β-Arbutin + Curcumone Diol (0.6 mg / mL + 0.9 mg / mL) 1:1.5 1.31

[0034] The above experiments demonstrate that β-arbutin and curcumone diol in the composition provided by this invention have synergistic whitening activity. Combining curcumone diol with β-arbutin significantly enhances the whitening activity of β-arbutin. Therefore, this composition can be used to prepare whitening and brightening daily chemical care products, such as facial cleansers, face creams, hand creams, lotions, and face masks.

Claims

1. Use of a composition for the manufacture of a whitening cosmetic, characterized in that: The composition consists of beta- arbutin and curcumoxide diol, and the mass ratio of beta- arbutin and curcumoxide diol is 1:1.

5.

2. Use according to claim 1, characterized in that: The cosmetic is a facial cleanser, a facial cream, a hand cream, a lotion or a facial mask.

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