An absorbable stent system

Abstract

The present invention discloses an absorbable stent system, which comprises an absorbable stent and a repair substance. The absorbable stent is made of a biodegradable material, and the repair substance is connected to the absorbable stent. The repair substance is used to repair tissues at a target site. The present invention provides an absorbable stent system, which can repair cells and tissues at corresponding positions while treating the target site, and has high structural strength.

Description

Technical Field

[0001] The invention relates to a system device for treating lesion blockage, belongs to the field of medical equipment, and particularly relates to a medical stent. Background Art

[0002] The use of absorbable stents for disease treatment has been widely used in the medical field, especially coronary stents, and has gradually developed to other parts of the human body, such as natural cavities.

[0003] Research has found that existing absorbable stents have the following defects when used:

[0004] 1. For some drug-loaded absorbable stents, patients may be allergic to the drugs loaded in the stent.

[0005] 2. Some absorbable stents have poor support, especially plastic absorbable stents.

[0006] 3. Some stents used in natural cavities, artificial openings or blood vessels of the human body are implanted with stents after repeated interventional dilatation and dredging treatments have failed. The stent is prone to restenosis after being absorbed or removed because after repeated interventional treatments, the cavity is stimulated to form scar tissue, which is prone to restenosis.

[0007] 4. Technically, some plastic stents cannot be well gripped on delivery systems such as balloon dilatation catheters. Summary of the invention

[0008] The present invention aims at least to provide a novel absorbable stent system.

[0009] The present invention provides an absorbable stent system, the absorbable stent system comprising:

[0010] An absorbable stent, wherein the absorbable stent is made of a biodegradable material;

[0011] A repair material is connected to the absorbable scaffold and is used to repair tissue at a target site.

[0012] In some embodiments, a coating is provided on the surface of the absorbable stent, and the coating includes the repair substance and / or a drug for treating the target site.

[0013] In some embodiments, the absorbable stent system comprises an absorbable film, at least one of the absorbable films is connected to the surface of the absorbable stent, the absorbable film contains the repair material, and / or,

[0014] The absorbable film contains a drug for treating the target site.

[0015] In some embodiments, the coating comprises a first coating containing the repair substance and a second coating containing the drug, wherein the first coating is located between the absorbable stent and the second coating.

[0016] In some embodiments, the absorbable film comprises:

[0017] A first film, wherein the first envelope containing the repair substance is connected to the surface of the absorbable stent; and a second film, wherein the second film containing the drug for treating the target site is connected to the first film.

[0018] In some embodiments, the absorbable stent system includes a plurality of absorbable stents nested with each other, an absorbable film is provided between two adjacent absorbable stents, and the absorbable film contains the repair substance.

[0019] In some embodiments, the absorbable stent is a bare stent, and / or,

[0020] The surface of the absorbable stent is provided with a coating, the coating includes the repair substance, and / or,

[0021] The surface of the absorbable stent is provided with a coating, and the coating includes a drug for treating the target site.

[0022] In some embodiments, the absorbable stent system includes a first stent and a second stent sleeved outside the first stent.

[0023] The surface of the first stent is coated with the repair substance, or the first stent is a bare stent;

[0024] The surface of the second stent is coated with the drug, or the second stent is a bare stent.

[0025] In some embodiments, the absorbable film includes a first film and a second film, wherein the first support, the first film, the second film and the second support are arranged in sequence from inside to outside.

[0026] In some embodiments, the second membrane is amniotic membrane, wherein

[0027] The first film carries stem cells or epithelial cells or endothelial cells; and / or,

[0028] The first film carries cell growth factors.

[0029] In some embodiments, the absorbable stent includes a first stent, a second stent and a third stent, and the absorbable film includes a first film and a second film, wherein the first stent, the first film, the second stent, the second film and the third stent are arranged in sequence from inside to outside.

[0030] In some embodiments, the absorbable film includes one or more of amniotic membrane and thin film, the film contains the repair substance, the repair substance includes one or more of cell growth factors and cell carriers, the cell carriers include repair cells and carriers for attracting and fixing the repair cells, and the repair cells include one or more of stem cells, epithelial cells and endothelial cells.

[0031] In some embodiments, the film is made of, but not limited to, polycarbonate, polylactic acid, polylactic-co-glycolic acid, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate, polytrimethylene carbonate.

[0032] In some embodiments, the vector comprises a protein, a peptide, or an antibody.

[0033] In some embodiments, the repair material includes one or more of amniotic membrane, cell growth factors, stem cells, epithelial cells, and endothelial cells.

[0034] In some embodiments, the material of the absorbable stent includes but is not limited to one or more of magnesium alloy, zinc alloy, polycarbonate, polylactic acid, polylactic acid-glycolic acid copolymer, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate and polytrimethylene carbonate.

[0035] In some embodiments, the absorbable stent is made of tubular carving, wire weaving, injection molding, casting, bonding, and welding, wherein the tubular is made by extrusion or injection molding and undergoes expansion and orientation processes.

[0036] In some embodiments, the coating is made of, but not limited to, polycarbonate, polylactic acid, polylactic-co-glycolic acid, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate, polytrimethylene carbonate.

[0037] In some embodiments, the absorbable film is clamped and fixed by two adjacent absorbable stents.

[0038] In some embodiments, the absorbable film is connected to the absorbable stent by suturing, heat welding, co-molding extrusion, co-molding, adhesives, lamination technology, or solvent bonding technology.

[0039] In some embodiments, the absorbable stent is cylindrical, conical, truncated cone, umbrella-shaped or non-standard shape after expansion to conform to the physiological structure of the target site.

[0040] In some embodiments, the diameter of the proximal end of the absorbable stent is smaller than the diameter of the distal end of the absorbable stent.

[0041] In some embodiments, the cell growth factors include but are not limited to platelet-derived growth factors (platelet-derived growth factor, PDGF; osteosarcoma-derived growth factor ODGF), epidermal growth factors (epidermal growth factor, EGF, transforming growth factor, TGFα and TGFβ), fibroblast growth factor (αFGF, βFGF), insulin-like growth factor (IGF-Ⅰ, IGF-Ⅱ), nerve growth factor (NGF), interleukin growth factors (IL-1, IL-1, IL-3, etc.), erythropoietin (EPO), and colony stimulating factor (CSF).

[0042] In some embodiments, the drug includes but is not limited to one or more of hormones, macrolides, and immunosuppressive drugs, such as rapamycin, everolimus, tacrolimus, sirolimus, mometasone furoate, and dexamethasone.

[0043] In some embodiments, the absorbable stent system further comprises a delivery system, wherein the delivery system is used to deliver the absorbable stent to the target site.

[0044] The delivery method of the absorbable stent system is self-expanding, and the delivery system includes a catheter, a push rod, a handle, and a stent compressor; or,

[0045] The delivery mode of the absorbable stent system is non-self-expanding, and the delivery system includes a balloon dilatation catheter.

[0046] The beneficial effects of the present invention are:

[0047] Compared with the prior art, the absorbable stent system provided by the present invention can not only treat the target part, but also repair the cells and tissues at the corresponding position, and has high structural strength. For designs with multiple absorbable stents and repair materials, the degradation rate, cell growth factor type, repair cell type, and degradation and repair sequence of the absorbable stent are designed according to the treatment needs of the specific part, so as to achieve gradient and precise treatment and repair. The absorbable film in the middle can also be used as a buffer transition layer during compression and gripping to prevent two adjacent absorbable stents from entangled or interfering with each other. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] Figure 1 This is a schematic structural diagram of an absorbable stent system according to Embodiment 1 of the present invention;

[0049] Figure 2 This is a schematic diagram of the structure of an absorbable stent system according to Embodiment 2 of the present invention;

[0050] Figure 3 This is a schematic diagram of the structure of an absorbable stent system according to Embodiment 3 of the present invention;

[0051] Figure 4 Schematic diagram of the structure of the absorbable stent system according to the fourth embodiment of the present invention;

[0052] Figure 5 This is a schematic diagram of the structure of an absorbable stent system according to Embodiment 5 of the present invention;

[0053] Figure 6 This is a schematic diagram of the structure of an absorbable stent system according to Embodiment 6 of the present invention;

[0054] Fig. 7A -B are schematic structural diagrams of an absorbable stent in the absorbable stent system of the present invention;

[0055] Figure 7C It is a schematic diagram of a partially enlarged structure of an absorbable stent in the absorbable stent system of the present invention;

[0056] Fig.7D It is a schematic diagram of the structure of an absorbable stent with a drug coating in the absorbable stent system of the present invention;

[0057] Fig. 7E It is a schematic diagram of the structure of an absorbable stent or an absorbable film in the absorbable stent system of the present invention after being pressed or compressed;

[0058] Figure 8 It is a structural schematic diagram of another absorbable stent system in the present invention;

[0059] Fig.9A -E is a schematic diagram of a stent pattern unit of an absorbable stent in the absorbable stent system of the present invention;

[0060] Fig.10 This is a schematic diagram of the structure of the absorbable stent system of the present invention when it is implanted at the lesion site;

[0061] Fig.11A It is a schematic structural diagram of the absorbable stent system of the present invention after the absorbable stent is expanded;

[0062] Fig. 11B It is a schematic diagram of the enlarged structure of the front end of the absorbable stent system in the present invention;

[0063] Fig. 11C It is a schematic structural diagram of the absorbable stent system of the present invention before the absorbable stent is expanded.

[0064] The present invention will be further described below in conjunction with the accompanying drawings and specific implementation methods. DETAILED DESCRIPTION

[0065] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0066] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0067] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0068] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0069] In the description of the embodiments of the present invention, it should be noted that the indicated orientation or positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the application product is usually placed when in use, or the orientation or positional relationship commonly understood by those skilled in the art, or the orientation or positional relationship in which the application product is usually placed when in use, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, the terms "first" and "second" are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0070] In the description of the embodiments of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0071] The absorbable stent system includes an absorbable stent and a repair material for repairing the tissue of the target site, and the repair material is connected to the absorbable stent. The absorbable stent can also be provided with a drug for treating the target site. The absorbable stent system also includes a delivery system, which is used to deliver the absorbable stent to the target site. The delivery method of the absorbable stent system is self-expanding. The delivery system includes a catheter, a push rod, a handle, and a stent compressor. The stent is compressed by the stent compressor and then loaded into the distal end of the catheter. After the catheter is delivered to the target site, the push rod is used to enter from the proximal end to push out the absorbable stent and the repair material, and then exit the delivery system. The delivery method of the absorbable stent system can also be non-self-expanding, and the delivery system includes a balloon dilatation catheter. The balloon of the balloon dilatation catheter is a tube-shaped or truncated cone-shaped shape that can adapt to the shape of the site of use. The absorbable stent and the repair material are pressed and gripped onto the balloon dilatation catheter. The absorbable stent and the repair material are pressed and gripped onto the balloon dilatation catheter. After the balloon dilatation catheter is delivered to the target site, the balloon is filled, and the absorbable stent and the repair material are expanded at the same time. The balloon is deflated and removed.

[0072] The absorbable stent is made of biodegradable materials, and the materials of the absorbable stent include but are not limited to pure magnesium, magnesium alloy, pure iron, iron alloy, polycarbonate, polylactic acid, polylactic acid-glycolic acid copolymer, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate, polytrimethylene carbonate, zinc alloy, and one or more thereof. The absorbable stent can be of regular shape or non-standard shape. The size of the absorbable stent is designed to be able to enter a specific part and fit the size of the tissue after expansion, and meet the basic performance requirements. The stent can be a porous or non-porous structure. The absorbable stent can be made of tubular carving, wire weaving, injection molding, casting, bonding, and welding. The absorbable stent can be laser engraved by extruded or injection molded tubular material, and the tubular material is made by expansion and orientation processes. After expansion, the absorbable stent is cylindrical, conical, truncated cone, umbrella-shaped or non-standard shape to meet the physiological structure of the target part. After the absorbable stent is expanded, the diameter of the proximal end of the truncated cone is smaller than the diameter of the distal end of the absorbable stent.

[0073] The repair material includes one or more of the whole amniotic membrane, cell growth factors, stem cells, epithelial cells, and endothelial cells. The cell growth factors can be extracted from animals and plants or artificially synthesized, including but not limited to platelet growth factors (platelet-derived growth factor, PDGF; osteosarcoma-derived growth factor ODGF), epidermal growth factors (epidermal growth factor, EGF, transforming growth factor, TGFα and TGFβ), fibroblast growth factor (αFGF, βFGF), insulin-like growth factor (IGF-Ⅰ, IGF-Ⅱ), nerve growth factor (NGF), interleukin growth factors (IL-1, IL-1, IL-3, etc.), erythropoietin (EPO), and colony stimulating factor (CSF).

[0074] Both the repair material and the drug can be connected to the absorbable stent in the form of a coating or an absorbable film. For example,

[0075] When in the form of a coating, the coating is mixed with a repair substance and / or a drug and then sprayed on the surface of the absorbable stent (for example, one or more cell growth factors and drugs are mixed). The coating is prepared from, but not limited to, polycarbonate, polylactic acid, polylactic acid-co-glycolic acid, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate, and polytrimethylene carbonate.

[0076] When in the form of an absorbable film, the repair material itself (such as amniotic membrane) can be directly an absorbable film, or the repair material (such as one or more of cell growth factors and cell carriers) can be set on an elastic film with a certain thickness, and the film is made of but not limited to polycarbonate, polylactic acid, polylactic acid-glycolic acid copolymer, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate, polytrimethylene carbonate. The cell carrier includes repair cells and a carrier for attracting and fixing the repair cells. The repair cells with cell regeneration and repair function include one or more of stem cells, epithelial cells and endothelial cells, and the carrier contains proteins, peptides or antibodies. The absorbable film can be a porous or non-porous structure.

[0077] The repair material can be a film containing only cell growth factors, which releases cell repair factors to repair tissue cells, or a film that releases cell repair factors while releasing cells, or releases repair cells alone. The second layer of repair material or the second layer of absorbable scaffold surface releases cell growth factors that help the growth of tissue cells and released repair cells. Simple cell growth factors have certain cell repair capabilities. The repair ability of using cell growth factors that release cells and help cell growth is stronger than that of simple cell growth factors.

[0078] The category of drugs is drugs suitable for treating specific parts, and the drugs include but are not limited to hormones, macrolides, immunosuppressive drugs, such as rapamycin, everolimus, tacrolimus, sirolimus, mometasone furoate, and dexamethasone.

[0079] There may be one or more absorbable stents, which can enhance the supporting force of the absorbable stent system. In an absorbable stent system, the absorbable stent may be a bare stent, or a coating containing a repair substance and / or a drug may be provided on the surface of the absorbable stent. When multiple absorbable stents are included, the multiple absorbable stents are preferably nested with each other, and one or more absorbable films containing a repair substance and / or a drug are provided between two adjacent absorbable stents. For designs with multiple absorbable stents and repair substances, the degradation rate, cell growth factor type, repair cell type, and degradation and repair sequence of the absorbable stent are designed according to the treatment needs of specific parts to achieve gradient and precise treatment and repair. The absorbable film in the middle can also be used as a transition layer for buffering during compression and gripping to prevent two adjacent absorbable stents from entangled or interfering with each other.

[0080] The absorbable film and the absorbable stent are connected in various ways. When at least two absorbable stents are included, the absorbable film between the two absorbable stents is clamped and fixed by the two absorbable stents. In addition, the absorbable film can also be connected to the absorbable stent by suturing, heat welding, co-molding extrusion, co-molding injection molding, adhesives, lamination technology, and solvent connection technology.

[0081] For the scheme containing multiple absorbable stents, the lesion site is first treated with an absorbable stent (with or without drug loading), and then the repair material or the second layer of absorbable stent containing the repair material (such as cell growth factor) is used for tissue repair. The first layer of absorbable stent releases drugs for treatment or uses magnesium bare stent to degrade rapidly for treatment. The first layer of absorbable stent can also contain drugs and repair materials at the same time to achieve the function of repairing while treating.

[0082] The present invention is described below in conjunction with different embodiments.

[0083] Embodiment 1

[0084] like Figure 1As shown, the absorbable stent system in this embodiment includes an absorbable stent 11 and an absorbable film 12 containing a repair substance disposed on the inner surface of the absorbable stent 11. The absorbable stent 11 may be a stent loaded with drugs (in the form of a coating), and for some absorbable stents 11 applied to cavities without drugs, they may also be bare stents. After the absorbable stent 11 releases the drugs for treating the disease, the absorbable stent 11 is gradually endothelialized or degraded, and the repair substances (such as cell growth factors or epithelial cells or endothelial cells or stem cells) in the absorbable film 12 are released, accelerating tissue repair and reducing scar formation.

[0085] Embodiment 2

[0086] like Figure 2 As shown, the absorbable stent system in this embodiment includes a first stent 23 and a second stent 21 sleeved on the outside of the first stent 23 , and an absorbable film 22 containing the repair material is provided between the first stent 23 and the second stent 21 .

[0087] The second stent 21 can play a restraining role for some first stents 23 that are difficult to compress and grasp, so that the second stent 23 that is difficult to compress and grasp can be compressed and grasped. The absorbable film 22 in the middle is a whole amniotic membrane, or a film carrying stem cells or epithelial cells or endothelial cells, or a film containing cell growth factors, or a film carrying stem cells or epithelial cells and cell growth factors. The absorbable film 22 can also be used as a buffer transition layer during compression and grasping to prevent the second stent 21 and the first stent 23 from being entangled or interfering with each other. The second stent 21 carries drugs in the form of a coating, or it can be a pure magnesium or magnesium alloy bare stent that degrades very quickly. The first stent 23 can be a bare stent, or a coating containing one or more cell growth factors can be set on the surface. The absorbable film 22 releases repair substances (such as cell growth factors or epithelial cells or endothelial cells or stem cells, or simultaneously releases cell growth factors and epithelial cells or endothelial cells or stem cells) to accelerate tissue repair and reduce scar formation. In particular, when the second stent 21 is a magnesium alloy bare stent that degrades very quickly, the fast degradation characteristics of magnesium alloy are utilized to make the contacted tissue partially alkaline, thereby killing bacteria or adhesions and hyperplastic tissues, and achieving the purpose of treatment. This design is particularly suitable for some patients who are allergic to drugs carried by the stent.

[0088] Embodiment 3

[0089] like Figure 3As shown, the absorbable stent system in this embodiment includes a first stent 35, a second stent 33 and a third stent 31. Each absorbable stent can be a bare stent or contain a coating (the coating contains drugs or repair substances such as cell growth factors). The absorbable film containing the repair substance includes a first film 34 and a second film 32, wherein the first stent 35, the first film 34, the second stent 33, the second film 32 and the third stent 31 are arranged in sequence from the inside to the outside. The first film 34 and the second film 32 can not only release repair substances such as cell growth factors or cells, but also serve as a transition layer for buffering during compression and gripping. The third stent 31 outside can play a significant restraining role for some second stents 33 that are difficult to compress and grip, so that the second stent 33 or the third stent 35 that are difficult to compress and grip can be compressed and gripped. This multi-layer stent design can significantly improve the overall support force and can be used in some parts that require very strong support force. The degradation rate, cell growth factor type, repair cell type, and degradation and repair sequence of the absorbable stent are designed according to the treatment needs of specific parts. The design of multi-layer absorbable stents and repair materials can treat and repair the same part at multiple levels, achieving gradient and refined treatment and repair.

[0090] Embodiment 4

[0091] like Figure 4 As shown, the absorbable stent system in this embodiment includes an absorbable stent 43, a first film 42 and a second film 41. The second film 41 is provided with drugs, which play a therapeutic role when the drugs are released. The first film 42 is provided with repair substances, which release repair substances such as cell growth factors or cells or cell growth factors and cells at the same time to play a repair role. The absorbable stent 43 plays a supporting role as a skeleton, and can be a bare stent or an absorbable coated stent with one or more cell growth factors on the surface.

[0092] Embodiment 5

[0093] like Figure 5As shown, the absorbable stent system in this embodiment includes a first stent 54 and a second stent 51 sleeved on the outside of the first stent 54, and absorbable films of a first film 53 and a second film 52 are sequentially arranged from the inside to the outside between the first stent 54 and the second stent 51. In this embodiment, the second stent 51 is a bare stent or provided with drugs in the form of a coating, and the first stent 54 is a bare stent or provided with a repair substance (such as one or more cell growth factors) in the form of a coating. In this embodiment, the second film 52 is a whole amniotic membrane, and the first film 53 is a film containing stem cells, epithelial cells, or endothelial cells, or a film containing cell growth factors, or a film carrying stem cells, epithelial cells, or endothelial cells and cell growth factors at the same time. Simple cell growth factors have a certain cell repair ability. The repair ability of using cell growth factors that release cells and help cell growth is stronger than that of simple cell growth factors.

[0094] Embodiment 6

[0095] like Figure 6 As shown, in the absorbable stent system of this embodiment, the surface of the absorbable stent 61 is directly provided with a repair material in the form of a coating, without the need to provide an absorbable film. The surface of the absorbable stent 61 can also be provided with drugs in the form of a coating. For example, the absorbable stent 61 can be sprayed with drugs and cell growth factors at the same time, and the drugs and cell growth factors can be released at the same time, thereby achieving the effect of repairing while treating. The surface coating can also be achieved by spraying cell growth factors first and then spraying drugs, so that the absorbable stent 61 first releases drugs and then releases cell growth factors, ultimately achieving the effect of first treating and then repairing.

[0096] Fig. 7A -E shows a structural example diagram of an absorbable stent with a porous structure of the present invention, an absorbable stent prepared by laser engraving of a stent tube, which contains an absorbable stent at a proximal end 704 and a distal end 705, and a plurality of stent rings 711 interconnected by stent connecting rods 706 constitute a stent pattern unit 708. The absorbable stent has a stent outer surface 701, a stent inner surface 702, and a stent wall thickness 703, and the gap area between the plurality of stent pattern units 708 is a gap 712. It can also be seen that a repairable film 710 (including amniotic membrane) with a certain wall thickness 707 is connected to the absorbable stent. The drug 709 is disposed on the surface of the stent pattern unit 708 and in the gap 712 of the absorbable stent by spraying.

[0097] like Figure 8 As shown, an absorbable film 804 is sandwiched between two absorbable stents 802. Fig.10As shown, after the absorbable stent is implanted into a natural or artificial opening (such as a cavity or blood vessel) 809 in the human body, it contacts the blood vessel or human organ 810 to start treatment and repair. Fig.9A -E shows schematic diagrams of several bracket pattern units 708 of different shapes and connection methods.

[0098] Fig.11A -C shows a schematic diagram of the structure of the entire absorbable stent, wherein the delivery system includes a balloon 805, a balloon dilatation catheter 801 and a guide wire 803, and an absorbable film 804 is provided on the absorbable stent 802, and the absorbable film 804 includes a repair material 806 (such as stem cells, epithelial cells, endothelial cells).

[0099] The above disclosure is only the preferred embodiment of the present invention, which certainly cannot be used to limit the scope of rights of the present invention. Therefore, equivalent changes made according to the scope of the patent application of the present invention are still within the scope covered by the present invention.

Claims

1. An absorbable stent system, characterized in that: The absorbable stent system comprises: An absorbable stent, the absorbable stent is made of a biodegradable material, the absorbable stent comprises a first stent and a second stent sleeved on the outside of the first stent, the first stent is provided with one or more cell growth factors in the form of a coating, the second stent is provided with drugs in the form of a coating, An absorbable film, the absorbable film includes a first film and a second film arranged in sequence from the inside to the outside between the first support and the second support, the first film is a film carrying stem cells or epithelial cells or endothelial cells and cell growth factors at the same time, and the film is prepared by one or more of polycarbonate, polylactic acid, polylactic acid-glycolic acid copolymer, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate, and polytrimethylene carbonate, and the second film is a whole amniotic membrane, The cell growth factors include platelet growth factors, epidermal growth factors, fibroblast growth factors, insulin-like growth factors, nerve growth factors, interleukin growth factors, erythrocyte growth factors, colony stimulating factors, The drugs include one or more of hormones, macrolides, and immunosuppressive drugs.

2. The absorbable stent system according to claim 1, characterized in that: The material of the absorbable stent includes one or more of pure magnesium, magnesium alloy, zinc alloy, pure iron, iron alloy, polycarbonate, polylactic acid, polylactic acid-glycolic acid copolymer, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate and polytrimethylene carbonate.

3. The absorbable stent system according to claim 1, characterized in that: The absorbable stent is made by carving a tube, weaving a wire, injection molding, casting, bonding and welding, wherein the tube is made by extrusion or injection molding and undergoing expansion and orientation processes.

4. The absorbable stent system according to claim 1, characterized in that: The coating is prepared from one or more of polycarbonate, polylactic acid, polylactic acid-co-glycolic acid, polyurethane, gelatin, polycaprolactone, polydioxolane, polyglycolide-trimethylene carbonate, and polytrimethylene carbonate.

5. The absorbable stent system according to claim 1, characterized in that: The absorbable film is clamped and fixed by the first support and the second support.

6. The absorbable stent system according to claim 1, characterized in that: The absorbable film is connected to the absorbable stent by suturing, heat welding, co-molding extrusion, co-molding injection molding, adhesives, lamination technology, and solvent connection technology.

7. The absorbable stent system according to claim 1, characterized in that: The absorbable stent is cylindrical, conical, truncated cone, umbrella-shaped or non-standard shape after expansion.

8. The absorbable stent system according to claim 1, characterized in that: The diameter of the proximal end of the absorbable stent is smaller than the diameter of the distal end of the absorbable stent.

9. The absorbable stent system according to claim 1, characterized in that: The drug includes one or more of rapamycin, everolimus, tacrolimus, sirolimus, mometasone furoate, and dexamethasone.

10. The absorbable stent system according to claim 1, characterized in that: The absorbable stent system further comprises a delivery system, and the delivery system is used to deliver the absorbable stent to a target site. The delivery method of the absorbable stent system is self-expanding, and the delivery system includes a catheter, a push rod, a handle, and a stent compressor; or, The delivery mode of the absorbable stent system is non-self-expanding, and the delivery system includes a balloon dilatation catheter.

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