Method for controlling pests and composition for controlling pests

Abstract

Provided is a method for controlling pests, etc., which comprises applying 3-endo-[2-propyloxy-4-(trifluoromethyl) phenoxy]-9-[5-(trifluoromethyl)-2-pyridyloxy]-9-azabicyclo[3.3.1]nonane together with an insecticidal or acaricidal active ingredient such as an effective ingredient of an insecticide or acaricide having an action mechanism classified by the IRAC code.

Description

Technical Field

[0001] This invention relates to methods for controlling pests and compositions of pest control agents. More specifically, this invention relates to methods that are safe and capable of controlling a variety of pests even at low dosages, and pest control compositions suitable for such methods.

[0002] This application claims priority based on Japanese Patent Application No. 2018-045236, filed in Japan on March 13, 2018, the contents of which are incorporated herein by reference. Background Technology

[0003] Patent Document 1 discloses a pest control composition containing a cyclic amine compound having a specific structure and at least one selected from neonicotinoid compounds, organophosphate insecticides, carbamate insecticides, synthetic pyrethroid insecticides, IGR insecticides, other insecticides and acaricides, and fungicides for agricultural and horticultural use.

[0004] Existing technical documents

[0005] Patent documents

[0006] Patent Document 1: Japanese Patent Application Publication No. 2013-241352

[0007] Patent Document 2: WO2011 / 078081A1 Summary of the Invention

[0008] The objective of this invention is to provide a method that is safe and can control various pests even at low dosages, and a pest control composition suitable for this method.

[0009] In order to solve the above-mentioned problems, in-depth research was conducted, and as a result, the present invention comprising the following means was completed.

[0010] That is, the present invention includes the following methods.

[0011] [1] A method for controlling pests, comprising applying 3-oper-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridinoxy]-9-azabicyclo[3.3.1]nonane together with an insecticidal or acaricidal active ingredient to the target organism.

[0012] [2] According to the control method described in [1], the insecticidal or acaricidal active ingredient is the effective ingredient of an insecticidal or acaricidal agent having a mechanism of action classified by IRAC coding.

[0013] [3] According to the control method described in [1], the insecticidal or acaricidal active ingredient is selected from (1) acetylcholinesterase inhibitors, (2) GABA-agonist chloride channel antagonists, (3) sodium channel modulators, (5) nicotinic acetylcholine receptor allosteric modulators, (6) glutamate agonist chloride channel allosteric modulators, (7) juvenile hormone analogs, (8) other non-specific (multi-site) inhibitors, (9) string organ TRPV channel modulators, (10) mite growth inhibitors, (11) insect midgut membrane disruptors derived from microorganisms, (12) mitochondrial ATP biosynthesis enzyme inhibitors, (13) oxidative phosphorylation uncoupling agents that disrupt proton gradients, (14) nicotinic acetylcholine receptor channel blockers, and (15) chitin. Synthesis inhibitor type 0, (16) chitin synthesis inhibitor type 1, (17) dipteran insect molting inhibitor, (18) molting hormone receptor agonist, (19) octopus amine receptor agonist, (20) mitochondrial electron transport system complex III inhibitor, (21) mitochondrial electron transport system complex I inhibitor, (22) voltage-dependent sodium channel blocker, (23) acetyl-CoA carboxylase inhibitor, (24) mitochondrial electron transport system complex IV inhibitor, (25) mitochondrial electron transport system complex II inhibitor, (28) raniline receptor modulator, (29) string instrument modulator, (30) GABA agonist chloride channel allosteric modulator and (UN) at least one of the following:

[0014] [4] According to the control method described in [1], the insecticidal or acaricidal active ingredient is selected from alanycarb, aldicarb, etc. Bendiocal, carbofuran, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, fenobucarb, formetate, isoprocarb, methiocarb, methomyl, oxamyl Pirimicarb, propoxur, thiodicarb, thiofanox, triazamate, trimetacarb, xylylcarb, fenothiocarb, MIPC, aldoxycarb, allyxycarb, aminocarb, bufencarb, cloethocarb, promecarb;

[0015] Acetaminophen, methyl pyridine Phosphorus (azamethiphos), ethyl azinphos-ethyl, methyl azinphos-methyl, cadusafos, chlorethoxyphos, chlorfenvinphos, chlormephos, chlorpyrifos, coumaphos, cyanophos, demeton-S-methyl, diazinon, didrotophos, dimethoate, disulfoton, EPN, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, imicyafos, isocarbophos, iso... Isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosmet, phosamine osphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, prothiofos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, trichlorfon, bromophos ethyl), carbophenothion, cyanofenphos, demeton-S-methyl sulfone, dialifos, dichlofenthion, dioxabenzofos, fensulfothion, flupyrazofos, fonofos, fosmethilan, isazofos, jodfenphos, methacrifos, pyrimiphos-ethyl, phosphocarb, prothoate;

[0016] Acetobacter, chlordane, endosulfan, ethiprole, fipronil, pyrafluprole, pyriprole, camphechlor, heptachlor, dienochlor;

[0017] Acrinathrin, d-cis-trans allethrin, d-trans arethrin, bifenthrin, bioallethrin, and bioaresulin S-cyclopentyl isomer isomer), bioresmethrin, cycloprothrin, cyfluthrin, β-cyfluthrin, cyhalothrin, λ-cyhalothrin, γ-cyhalothrin, cypermethrin, α-cypermethrin, β-cypermethrin, θ-cypermethrin, ζ-cypermethrin, cyphenothrin [(1R)-trans isomer] isomer]), deltamethrin, empenthrin[(EZ)-(1R)-Isomer], esfenvalerate, ethofenprox, fenpropathrine, flucythrinate, flumethrin, τ-fluvalinate, imiprothrin, kadethrin, permethrin, phenothrin[(1R)-trans isomer] isomer, prallethrin, pyrethrum, silafluofen, tefluthrin, tetramethrin, tetramethrin[(1R)-isomer], tralomethrin, transfluthrin, allethrin, pyrethrin, pyrethrin II), Pyrethrin II, Profluthrin, Dimefluthrin, Bioethanomethrin, Biopermethrin, Transpermethrin, Fenfluthrin, Fenpirithrin, Flubrocythrinate, Flufenprox, Metofluthrin, Protrifenbute, Pyresmethrin, Terallethrin, Meperfluthrin, Tetramethylfluthrin;

[0018] Acetamiprid, Clothianidin, Dinotefuran, Imidacloprid, Nitenpyram, Nithiaazine, Thiacloprid, Thiamethoxam, Sulfoxaflor, Nicotine, Flupyradifurone, Triflumezopyrim;

[0019] Ethyl spinosad (spinetoram), spinosad;

[0020] Abamectin, emamectin-benzoate, lepimectin, milkemectin, ivermectin, selamectin, doramectin, eprinomectin, moxidectin, milbemycin, milbemycin oxime;

[0021] Hydroprene, Kinoprene, Methoprene, Fenoxycarb, Pyriproxyfen, Diofenolan, Epofenonane, Triprene;

[0022] Chloropicrin, sulfuryl fluoride, borax, tartar emetic, and metam-sodium;

[0023] Pymetrozine, pyrifluquinazon, and afidopyropen;

[0024] Clofentezine, diflovidazin, hexythiazox, etoxazole;

[0025] Bacillus thuringiensis subsp. Israelensis, Bacillus sphaericus, Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki, Bacillus thuringiensis subsp. tenbrionis, Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / Cry35Ab1;

[0026] Diafenthiuron, propargite, and tetradifon;

[0027] Chlorfenapyr, sulfluramid, DNOC, binapacryl, dinobuton, and dinocap;

[0028] Bensultap, cartap hydrochloride, nereistoxin, thiosultap-sodium, and thiocyclam;

[0029] Bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, buprofezin, fluazuron;

[0030] Cyromazine;

[0031] Chlorofenozide, halofenozide, methoxyfenozide, tebufenozide;

[0032] Amitraz, Demiditraz, Chlordimeform;

[0033] Acequinocyl, fluacrylpyrim, hydramethylnon, and bifenazate;

[0034] Fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, rotenone;

[0035] Indoxacarb, metaflumizone;

[0036] Spirodiclofen, spiromesifen, spirotetramat, 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate;

[0037] Aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, and cyanide;

[0038] Cyenopyrafen, cyflumetofen, and 3'-isobutyl-N-isobutyryl-1,3,5-trimethyl-4'-[2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]pyrazole-4-carboxyaniline.

[0039] Chlorantraniliprole, cyantraniliprole, fulbendiamide, cyclaniliprole, tetraliprole;

[0040] Flunicamid;

[0041] broflanilide, fluorine Fluxametamide;

[0042] Azadirachtin, pyridalyl, metaldehyde, dicyclanil, fenoxacrim, fentrifanil, flubenzimine Metoxadiazone, sodium oleate, frometoquinone, flufiprole, tralopyril, methylneodecanamide, fluralaner, afoxolaner, dicloromezotiazine, and 2-[3-(ethylsulfonyl)-2-pyridyl]-5-[(trifluoromethyl)sulfonyl]benzo[d] At least one of the oxazosulfyl compounds.

[0043] [5] According to the control method described in [1], the insecticidal or acaricidal active ingredient is hexythiazox or etoxazole.

[0044] [6] The control method according to any one of [1] to [5], wherein the pest is an insect or a mite.

[0045] [7] A pest control composition containing 3-oper-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridoxy]-9-azabicyclo[3.3.1]nonane and an insecticidal or acaricidal active ingredient.

[0046] [8] The pest control composition according to [7], wherein the insecticidal or acaricidal active ingredient is an effective ingredient of an insecticidal or acaricidal agent having a mechanism of action classified by IRAC code.

[0047] [9] According to the pest control composition described in [7], the insecticidal or acaricidal active ingredient is selected from (1) acetylcholinesterase inhibitors, (2) GABA-agonist chloride channel antagonists, (3) sodium channel modulators, (5) nicotinic acetylcholine receptor allosteric modulators, (6) glutamate agonist chloride channel allosteric modulators, (7) juvenile hormone analogs, (8) other non-specific (multi-site) inhibitors, (9) string organ TRPV channel modulators, (10) mite growth inhibitors, (11) insect midgut membrane disruptors derived from microorganisms, (12) mitochondrial ATP biosynthesis enzyme inhibitors, (13) oxidative phosphorylation uncoupling agents that disrupt proton gradients, (14) nicotinic acetylcholine receptor channel blockers, and (15) [unclear text - likely a continuation of the previous sentence]. Chitin synthesis inhibitor type 0, (16) chitin synthesis inhibitor type 1, (17) Diptera insect molting inhibitor, (18) molting hormone receptor agonist, (19) octopus amine receptor agonist, (20) mitochondrial electron transport system complex III inhibitor, (21) mitochondrial electron transport system complex I inhibitor, (22) voltage-dependent sodium channel blocker, (23) acetyl-CoA carboxylase inhibitor, (24) mitochondrial electron transport system complex IV inhibitor, (25) mitochondrial electron transport system complex II inhibitor, (28) raniline receptor modulator, (29) string organ modulator, (30) GABA agonist chloride channel allosteric modulator and (UN) at least one of the following:

[0048]

[10] The pest control composition according to [7], wherein the insecticidal or acaricidal active ingredient is selected from alanycarb, aldicarb, etc. Bendiocal, carbofuran, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, fenobucarb, formetate, isoprocarb, methiocarb, methomyl, oxamyl Pirimicarb, propoxur, thiodicarb, thiofanox, triazamate, trimetacarb, xylylcarb, fenothiocarb, MIPC, aldoxycarb, allyxycarb, aminocarb, bufencarb, cloethocarb, promecarb;

[0049] Acetaminophen, methyl pyridine Phosphorus (azamethiphos), ethyl azinphos-ethyl, methyl azinphos-methyl, cadusafos, chlorethoxyphos, chlorfenvinphos, chlormephos, chlorpyrifos, coumaphos, cyanophos, demeton-S-methyl, diazinon, didrotophos, dimethoate, disulfoton, EPN, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, imicyafos, isocarbophos, iso... Isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosmet, phosamine osphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, prothiofos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, trichlorfon, bromophos ethyl), carbophenothion, cyanofenphos, demeton-S-methyl sulfone, dialifos, dichlofenthion, dioxabenzofos, fensulfothion, flupyrazofos, fonofos, fosmethilan, isazofos, jodfenphos, methacrifos, pyrimiphos-ethyl, phosphocarb, prothoate;

[0050] Acetobacter, chlordane, endosulfan, ethiprole, fipronil, pyrafluprole, pyriprole, camphechlor, heptachlor, dienochlor;

[0051] Acrinathrin, d-cis-trans allethrin, d-trans arethrin, bifenthrin, bioallethrin, and bioaresulin S-cyclopentyl isomer isomer), bioresmethrin, cycloprothrin, cyfluthrin, β-cyfluthrin, cyhalothrin, λ-cyhalothrin, γ-cyhalothrin, cypermethrin, α-cypermethrin, β-cypermethrin, θ-cypermethrin, ζ-cypermethrin, cyphenothrin [(1R)-trans isomer] isomer]), deltamethrin, empenthrin[(EZ)-(1R)-Isomer], esfenvalerate, ethofenprox, fenpropathrine, flucythrinate, flumethrin, τ-fluvalinate, imiprothrin, kadethrin, permethrin, phenothrin[(1R)-trans isomer] isomer, prallethrin, pyrethrum, silafluofen, tefluthrin, tetramethrin, tetramethrin[(1R)-isomer], tralomethrin, transfluthrin, allethrin, pyrethrin, pyrethrin II), Pyrethrin II, Profluthrin, Dimefluthrin, Bioethanomethrin, Biopermethrin, Transpermethrin, Fenfluthrin, Fenpirithrin, Flubrocythrinate, Flufenprox, Metofluthrin, Protrifenbute, Pyresmethrin, Terallethrin, Meperfluthrin, Tetramethylfluthrin;

[0052] Acetamiprid, Clothianidin, Dinotefuran, Imidacloprid, Nitenpyram, Nithiaazine, Thiacloprid, Thiamethoxam, Sulfoxaflor, Nicotine, Flupyradifurone, Triflumezopyrim;

[0053] Ethyl spinosad (spinetoram), spinosad;

[0054] Abamectin, emamectin-benzoate, lepimectin, milkemectin, ivermectin, selamectin, doramectin, eprinomectin, moxidectin, milbemycin, milbemycin oxime;

[0055] Hydroprene, Kinoprene, Methoprene, Fenoxycarb, Pyriproxyfen, Diofenolan, Epofenonane, Triprene;

[0056] Chloropicrin, sulfuryl fluoride, borax, tartar emetic, and metam-sodium;

[0057] Pymetrozine, pyrifluquinazon, and afidopyropen;

[0058] Clofentezine, diflovidazin, hexythiazox, etoxazole;

[0059] Bacillus thuringiensis subsp. Israelensis, Bacillus sphaericus, Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki, Bacillus thuringiensis subsp. tenbrionis, Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / Cry35Ab1;

[0060] Diafenthiuron, propargite, and tetradifon;

[0061] Chlorfenapyr, sulfluramid, DNOC, binapacryl, dinobuton, and dinocap;

[0062] Bensultap, cartap hydrochloride, nereistoxin, thiosultap-sodium, and thiocyclam;

[0063] Bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, buprofezin, fluazuron;

[0064] Cyromazine;

[0065] Chlorofenozide, halofenozide, methoxyfenozide, tebufenozide;

[0066] Amitraz, Demiditraz, Chlordimeform;

[0067] Acequinocyl, fluacrylpyrim, hydramethylnon, and bifenazate;

[0068] Fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, rotenone;

[0069] Indoxacarb, metaflumizone;

[0070] Spirodiclofen, spiromesifen, spirotetramat, 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate;

[0071] Aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, and cyanide;

[0072] Cyenopyrafen, cyflumetofen, and 3'-isobutyl-N-isobutyryl-1,3,5-trimethyl-4'-[2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]pyrazole-4-carboxyaniline.

[0073] Chlorantraniliprole, cyantraniliprole, fulbendiamide, cyclaniliprole, tetraliprole;

[0074] Flunicamid;

[0075] broflanilide, fluorine Fluxametamide;

[0076] Azadirachtin, pyridalyl, metaldehyde, dicyclanil, fenoxacrim, fentrifanil, flubenzimine Metoxadiazone, sodium oleate, frometoquinone, flufiprole, tralopyril, methylneodecanamide, fluralaner, afoxolaner, dicloromezotiazine, and 2-[3-(ethylsulfonyl)-2-pyridyl]-5-[(trifluoromethyl)sulfonyl]benzo[d] At least one of the oxazosulfyl azoles.

[0077]

[11] According to the control method described in [7], the insecticidal or acaricidal active ingredient is hexythiazox or etoxazole.

[0078]

[12] A pest control composition according to any one of [7] to

[11] , wherein the pest is an insect or a mite.

[0079] According to the control method of the present invention, pests such as insects and mites can be controlled more safely with less dosage. The pest control composition of the present invention is applicable to pest control methods, particularly the control method of the present invention. The pest control composition of the present invention is particularly suitable for insecticides and acaricides used in agriculture and horticulture.

[0080] The pest control composition of the present invention contains compound A and compound B in a ratio suitable for the target organism, thus eliminating the need for separately measuring and mixing compounds A and B. The pest control composition of the present invention can be stored or transported in various forms, such as bags, bottles, boxes, and cans, depending on the formulation. Detailed Implementation

[0081] The method for controlling pests according to the present invention includes applying compound A together with compound B to the target organism.

[0082] Compound A is 3-oper-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridinoxy]-9-azabicyclo[3.3.1]nonane (CAS No.: 1332838-17-1, common name: acynonapyr). Compound A is a known substance that is believed to act on inhibitory glutamate receptors, causing behavioral abnormalities by disrupting neurotransmission, thereby exhibiting insecticidal or acaricidal effects. Compound A can be manufactured by the method described in Patent Document 2, etc.

[0083] Compound B is an insecticidal or acaricidal active ingredient, preferably an active ingredient of an insecticidal or acaricidal agent with a mechanism of action classified by IRAC codes.

[0084] Examples of insecticides or acaricides with mechanisms of action classified by IRAC coding include (1) acetylcholinesterase inhibitors, (2) GABA-agonist chloride channel antagonists, (3) sodium channel modulators, (5) nicotinic acetylcholine receptor allosteric modulators, (6) glutamate agonist chloride channel allosteric modulators, (7) juvenile hormone analogs, (8) other non-specific (multi-site) inhibitors, (9) string organ TRPV channel modulators, (10) mite growth inhibitors, (11) insect midgut membrane disruptors derived from microorganisms, (12) mitochondrial ATP biosynthesis enzyme inhibitors, (13) oxidative phosphorylation uncoupling agents that disrupt the proton gradient, (14) nicotinic acetylcholine receptor channel blockers, and (15) several Chitin synthesis inhibitor type 0, (16) chitin synthesis inhibitor type 1, (17) Diptera insect molting inhibitor, (18) molting hormone receptor agonist, (19) octopus amine receptor agonist, (20) mitochondrial electron transport system complex III inhibitor, (21) mitochondrial electron transport system complex I inhibitor, (22) voltage-dependent sodium channel blocker, (23) acetyl-CoA carboxylase inhibitor, (24) mitochondrial electron transport system complex IV inhibitor, (25) mitochondrial electron transport system complex II inhibitor, (28) rannylate receptor modulator, (29) string organ modulator, (30) GABA agonist chloride channel allosteric modulator and (UN) agents with unclear mechanism of action.

[0085] The following are specific examples of the above compound B.

[0086] (1) Acetylcholinesterase inhibitors: alanycarb, aldicarb Bendiocal, carbofuran, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, fenobucarb, formetanate, isoprocarb, methiocarb, methomyl, oxamyl, pirim Carbamate-based acetylcholinesterase inhibitors, including carbamates such as icarb, propoxur, thiodicarb, thiofanox, triazamate, trimetacarb, xylylcarb, fenothiocarb, MIPC, aldoxycarb, allyxycarb, aminocarb, bufencarb, cloethocarb, and promecarb.

[0087] Acetaminophen, methyl pyridine Phosphorus (azamethiphos), ethyl azinphos-ethyl, methyl azinphos-methyl, cadusafos, chlorethoxyphos, chlorfenvinphos, chlormephos, chlorpyrifos, coumaphos, cyanophos, demeton-S-methyl, diazinon, didrotophos, dimethoate, disulfoton, EPN, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, imicyafos, isocarbophos, iso... Isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosmet, phosamine osphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, prothiofos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, trichlorfon, bromophos Organophosphate acetylcholinesterase inhibitors, including ethyl, carbophenothion, cyanofenphos, demeton-S-methyl sulfone, dialifos, dichlofenthion, dioxabenzofos, fensulfothion, flupyrazofos, fonofos, fosmethilan, isazolofos, jodfenphos, methicrifos, pyrimiphos-ethyl, phosphocarb, and prothoate.

[0088] (2) GABA-agonist chloride channel antagonists: acetoprole, chlordane, endosulfan, ethiprole, fipronil, pyrafluprole, pyriprole, camphechlor, heptachlor, dienochlor.

[0089] (3) Sodium channel modulators: Acrinathrin, d-cis-transallethrin, d-transarethrin, bifenthrin, bioallethrin, bioaresulin S-cyclopentyl isomer isomer), bioresmethrin, cycloprothrin, cyfluthrin, β-cyfluthrin, cyhalothrin, λ-cyhalothrin, γ-cyhalothrin, cypermethrin, α-cypermethrin, β-cypermethrin, θ-cypermethrin, ζ-cypermethrin, cyphenothrin [(1R)-trans isomer] isomer]), deltamethrin, empenthrin[(EZ)-(1R)-Isomer], esfenvalerate, ethofenprox, fenpropathrine, flucythrinate, flumethrin, τ-fluvalinate, imiprothrin, kadethrin, permethrin, phenothrin[(1R)-trans isomer]isomer, prallethrin, pyrethrum, silafluofen, tefluthrin, tetramethrin, tetramethrin[(1R)-isomer], tralomethrin, transfluthrin, allethrin, pyrethrin, pyrethrin I I), Pyrethrin II, Profluthrin, Dimefluthrin, Bioethanomethrin, Biopermethrin, Transpermethrin, Fenfluthrin, Fenpirithrin, Flubrocythrinate, Flufenprox, Metofluthrin, Protrifenbute, Pyresmethrin, Terallethrin, Meperfluthrin, Tetramethylfluthrin.

[0090] (4) Nicotinic acetylcholine receptor allosteric modulators: acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam, sulfoxaflor, nicotine, flupyradifurone, triflumezopyrim.

[0091] (5) Nicotinic acetylcholine receptor allosteric modulators: spinosad and spintocin.

[0092] (6) Allosteric modulators of glutamate-stimulating chloride channels: abamectin, emamectin-benzoate, lepimectin, milbemectin, ivermectin, selamectin, doramectin, eprinomectin, moxidectin, milbemycin, and milbemycin oxime.

[0093] (7) Juvenile hormone analogs: hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen, diofenolan, epofenonane, triprene.

[0094] (8) Other non-specific inhibitors: chloropicrin, sulfuryl fluoride, borax, tartar emetic, and metam-sodium.

[0095] (9) String instrument TRPV channel modulators: pymetrozine, pyrifluquinazon, afidopyropen.

[0096] (10) Mite growth inhibitors: clofentezine, diflovidazin, hexythiazox, etoxazole.

[0097] (11) Insect midgut membrane disruptors derived from microorganisms: Bacillus thuringiensis subsp. Israelensis, Bacillus sphaericus, Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki, Bacillus thuringiensis subsp. tenebrionis, Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / Cry35Ab1.

[0098] (12) Inhibitors of mitochondrial ATP biosynthesis enzymes: diafenthiuron, propargite, tetradifon.

[0099] (13) Oxidative phosphoric acid uncoupling agents that disrupt the proton gradient: chlorfenapyr, sulfluramid, DNOC, binapacryl, dinobuton, and dinocap.

[0100] (14) Nicotinic acetylcholine receptor channel blockers: bensultap, cartap hydrochloride, nereistoxin, thiosultap-sodium, thiocyclam.

[0101] (15) Type 0 of chitin synthesis inhibitors: bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, chlorfluazuron.

[0102] (16) Type 1 chitin synthesis inhibitor: buprofezin.

[0103] (17) Ecliptic inhibitor of Diptera: Cyromazine.

[0104] (18) Ecdysone receptor agonists: chromafenozide, halofenozide, methoxyfenozide, tebufenozide.

[0105] (19) Octopus amine receptor agonists: amitraz, demiditraz, chlordimeform.

[0106] (20) Inhibitors of mitochondrial electron transport system complex III: acequinocyl, fluacrylpyrim, hydramethylnon, bifenazate.

[0107] (21) Inhibitors of mitochondrial electron transport system complex I: fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, rotenone.

[0108] (22) Voltage-dependent sodium channel blockers: indoxacarb, metaflumizone.

[0109] (23) Acetyl-CoA carboxylase inhibitors: spirodiclofen, spiromesifen, spirotetramat, 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate.

[0110] (24) Inhibitors of mitochondrial electron transport system complex IV: aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, and cyanide.

[0111] (25) Inhibitors of mitochondrial electron transport system complex II: cyenopyrafen, cyflumetofen, 3'-isobutyl-N-isobutyryl-1,3,5-trimethyl-4'-[2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]pyrazole-4-carboxyaniline.

[0112] (28) Lanni base receptor modulators: chlorantraniliprole, cyantraniliprole, fulbendiamide, cyclaniliprole, tetraliprole.

[0113] (29) String tuning agent: flunicamid.

[0114] (30) GABA-stimulating chloride channel allosteric modulators: broflanilide, fluorinated chloride... Fluxametamide.

[0115] (UN) Agents with unclear mechanisms of action: azadirachtin, pyridalyl, metaldehyde, dicyclanil, fenoxacrim, fentrifanil, flubenzimine Metoxadiazone, sodium oleate, flumetoquinone, flufiprole, tralopyril, methylneodecanamide, fluralaner, afoxolaner, dicloromezotiazine, 2-[3-(ethylsulfonyl)-2-pyridyl]-5-[(trifluoromethyl)sulfonyl]benzo[d] Oxazosulfyl.

[0116] Preferred combinations of compounds A and B used in the methods and compositions of the present invention include acynonapyr / alanycarb, acynonapyr / aldicarb, acynonapyr / bendiocarb, acynonapyr / carbofuran (benfuracarb), acynonapyr / butocarboxim, and acynonapyr / butoxycarboxim. r / carbaryl and acynonapyr, acynonapyr / carbofuran, acynonapyr / carbosulfan, acynonapyr / fenobucarb, acynonapyr / formetanate, acynonapyr / isoprocarb, acynonapyr / methiocarb, acynonapyr / methomyl, acynon apyr / oxamyl, acynonapyr / pirimicarb, acynonapyr / propoxur, acynonapyr / thiodicarb, acynonapyr / thiofanox, acynonapyr / triazamate, acynonapyr / trimetacarb, acynonapyr / xylylcarb, acynonapyr / fenoth iocarb), acynonapyr / MIPC, acynonapyr / aldoxycarb, acynonapyr / allyxycarb, acynonapyr / aminocarb, acynonapyr / bufencarb, acynonapyr / cloethocarb, acynonapyr / promecarb, acynonapyr / acephate, acynonapyr / methylpyridine Phosphorus (azamethiphos), acynonapyr / ethyl azinphos-ethyl, acynonapyr / methyl azinphos-methyl, acynonapyr / cadusafos, acynonapyr / chlorethoxyphos, acynonapyr / chlorfenvinphos, acynonapyr / chlormephos, acynonapyr / chlorpyrifos, acynonapyr / coumaphos, acynonapyr / cyanophos, acynonapyr / demeton-S-methyl, acynonapyr / diazinonphos azinon), acynonapyr / dicrotophos, acynonapyr / dimethoate, acynonapyr / disulfoton, acynonapyr / EPN, acynonapyr / famphur, acynonapyr / fenamiphos, acynonapyr / fenitrothion, acynonapyr / fenthion, acynonapyr / fosthiazate, acynonapyr / heptenophos, acynonapyr / imicyafos, acynonapyr / isocarbophos, acynonapyr / isocarbophos Isoxathion, acynonapyr, malathion, mecarbam, methamidophos, methidathion, mevinphos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosmet, phosphamid on), acynonapyr / phoxim, acynonapyr / pirimiphos-methyl, acynonapyr / profenofos, acynonapyr / propetamphos, acynonapyr / prothiofos, acynonapyr / sulfotep, acynonapyr / tebupirimfos, acynonapyr / temephos, acynonapyr / terbufos, acynonapyr / tetrachlorvinphos, acynonapyr / thiometon, acynonapyr / triazophos, acynonapyr / trichlorfon, acynonapyr / bromophosethyl), carbophenothion, cyanofenphos, demeton-S-methylsulfone, dialifos, dichlofenthion, dioxabenzofos, fensulfothion, fensulfothion Flupyrazofos, acynonapyr / fonofos, acynonapyr / fosmethilan, acynonapyr / isazofos, acynonapyr / jodfenphos, acynonapyr / methacrifos, acynonapyr / pyrimiphos-ethyl, acynonapyr / phosphocarb, acynonapyr / prothoate;

[0117] acynonapyr / acetoprole, acynonapyr / chlordane, acynonapyr / endosulfan, acynonapyr / ethiprole, acynonapyr / fipronil, acynonapyr / pyrafluprole, acynonapyr / pyriprole, acynonapyr / camphechlor, acynonapyr / heptachlor, acynonapyr / dienochlor;

[0118] Acrinathrin, d-cis-trans allethrin, d-trans arethrin, bifenthrin, bioallethrin, and bioaresulin S-cyclopentyl areomer are allethrin areomer areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers areomers are cyclopentyl ... isomer), acynonapyr / bioresmethrin, acynonapyr / cycloprothrin, acynonapyr / cyfluthrin, acynonapyr / β-cyfluthrin, acynonapyr / cyhalothrin, acynonapyr / λ-cyhalothrin, acynonapyr / γ-cyhalothrin othrin), acynonapyr / cypermethrin, acynonapyr / α-cypermethrin, acynonapyr / β-cypermethrin, acynonapyr / θ-cypermethrin, acynonapyr / ζ-cypermethrin, acynonapyr / cyphenothrin[(1R)-trans isomer](cyphenothrin[(1R)-trans)isomer]), acynonapyr / deltamethrin, acynonapyr / empenthrin[(EZ)-(1R)-Isomer], acynonapyr / esfenvalerate, acynonapyr / ethofenprox, acynonapyr / fenpropathrine, acynonapyr / fenvalerate, ac ynonapyr / flucythrinate, acynonapyr / flumethrin, acynonapyr / τ-fluvalinate, acynonapyr / imiprothrin, acynonapyr / kadethrin, acynonapyr / permethrin, acynonapyr / phenothrin[(1R)-trans isomer] isomer], acynonapyr / prallethrin, acynonapyr / pyrethrum, acynonapyr / silafluofen, acynonapyr / tefluthrin, acynonapyr / tetramethrin, acynonapyr / tetramethrin[(1R)-isomer], acynonapyr / tralomethrin, acynonapyr / transfluthrin, acynonapyr / allethrin, acynonapyr / pyrethrin, acynonapyr / pyrethrin I, acynonapyr / pyrethrin IIII), acynonapyr / profluthrin, acynonapyr / dimefluthrin, acynonapyr / bioethanomethrin, acynonapyr / biopermethrin, acynonapyr / transpermethrin, acynonapyr / fenfluthrin, acynonapyr / fenpirithrin, acynonapyr / bromofluoromethyl (flubrocythrinate), acynonapyr / flufenprox, acynonapyr / metofluthrin, acynonapyr / protrifenbute, acynonapyr / pyresmethrin, acynonapyr / terallethrin, acynonapyr / meperfluthrin, acynonapyr / tetramethylfluthrin;

[0119] acynonapyr / acetamiprid, acynonapyr / clothianidin, acynonapyr / dinotefuran, acynonapyr / imidacloprid, acynonapyr / nitenpyram, acynonapyr / nithiazine, acynonapyr / thiacloprid, acynonapyr / thiamethoxam, acynonapyr / sulfoxaflor, acynonapyr / nicotine, acynonapyr / flupyradifurone, acynonapyr / triflumezopyrim;

[0120] acynonapyr / ethyl spinosad (spinetoram), acynonapyr / spinosad;

[0121] Acynonapyr (abamectin), acynonapyr (emamectin-benzoate), acynonapyr (lepimectin), acynonapyr (milbemectin), acynonapyr (ivermectin), acynonapyr (selamectin), acynonapyr (doramectin), acynonapyr (eprinomectin), acynonapyr (moxidectin), acynonapyr (milbemycin), acynonapyr (milbemycin oxime);

[0122] acynonapyr / hydroprene, acynonapyr / kinoprene, acynonapyr / methoprene, acynonapyr / fenoxycarb, acynonapyr / pyriproxyfen, acynonapyr / diofenolan, acynonapyr / epofenonane, acynonapyr / triprene;

[0123] acynonapyr / chloropicrin, acynonapyr / sulfuryl fluoride, acynonapyr / borax, acynonapyr / tartar emetic, acynonapyr / Metam-sodium;

[0124] acynonapyr / pymetrozine, acynonapyr / pyrifluquinazon, acynonapyr / afidopyropen;

[0125] acynonapyr / clofentezine, acynonapyr / diflovidazin, acynonapyr / hexythiazox, acynonapyr / etoxazole;

[0126] Acynonapyr / Bacillus thuringiensis subsp. Israelensis, Acynonapyr / Bacillus sphaericus, Acynonapyr / Bacillus thuringiensis subsp. aizawai, Acynonapyr / Bacillus thuringiensis subsp. kurstaki, Acynonapyr / Bacillus thuringiensis subsp. tenbrionis, Acynonapyr / Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / Cry35Ab1;

[0127] acynonapyr / diafenthiuron, acynonapyr / propargite, acynonapyr / tetradifon;

[0128] acynonapyr / chlorfenapyr, acynonapyr / sulfluramid, acynonapyr / DNOC, acynonapyr / binapacryl, acynonapyr / dinobuton, acynonapyr / dinocap;

[0129] acynonapyr / bensultap, acynonapyr / cartaphydrochloride, acynonapyr / nereistoxin, acynonapyr / thiosultap-sodium, acynonapyr / thiocyclam;

[0130] acynonapyr / bistrifluron, acynonapyr / chlorfluazuron, acynonapyr / diflubenzuron, acynonapyr / flucycloxuron, acynonapyr / flufenoxuron, acynonapyr / lufenuron, acynonapyr / novaluron, acynonapyr / noviflumuron, acynonapyr / teflubenzuron, acynonapyr / triflumuron, acynonapyr / buprofezin, acynonapyr / fluazuron;

[0131] acynonapyr / cyromazine;

[0132] acynonapyr / chromafenozide, acynonapyr / halofenozide, acynonapyr / methoxyfenozide, acynonapyr / tebufenozide, acynonapyr / amitraz, acynonapyr / demiditraz, acynonapyr / chlordimeform;

[0133] acynonapyr / acequinocyl, acynonapyr / fluacrylpyrim, acynonapyr / hydramethylnon, acynonapyr / bifenazate;

[0134] acynonapyr / fenazaquin, acynonapyr / fenpyroximate, acynonapyr / pyrimidifen, acynonapyr / pyridaben, acynonapyr / tebufenpyrad, acynonapyr / tolfenpyrad, acynonapyr / rotenone;

[0135] acynonapyr / indoxacarb, acynonapyr / metaflumizone;

[0136] acynonapyr / spirodiclofen, acynonapyr / spiromesifen, acynonapyr / spirotetramat, acynonapyr / 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate (spiropidion);

[0137] Acidnonapyr (aluminium phosphide), acynonapyr (calcium phosphide), acynonapyr (phosphine), acynonapyr (zinc phosphide), acynonapyr (cyanide);

[0138] acynonapyr / cyenopyrafen, acynonapyr / cyflumetofen, acynonapyr / 3'-isobutyl-N-isobutyryl-1,3,5-trimethyl-4'-[2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]pyrazole-4-carboxyaniline;

[0139] acynonapyr / chlorantraniliprole, acynonapyr / cyantraniliprole, acynonapyr / fulbendiamide, acynonapyr / cyclaniliprole, acynonapyr / tetraniliprole;

[0140] acynonapyr / flonicamid;

[0141] acynonapyr / broflanilide, acynonapyr / fluorine Fluxametamide;

[0142] acynonapyr / azadirachtin, acynonapyr / pyridalyl, acynonapyr / metaldehyde, acynonapyr / dicyclanil, acynonapyr / fenoxacrim, acynonapyr / fentrifanil, acynonapyr / flubenzimine, acynonapyr / Metoxadiazone, sodium oleate, fometoquin, flufiprole, tralopyril, methylneodecanamide, fluralaner, afoxolaner, dicloromezotiaz, and 2-[3-(ethylsulfonyl)-2-pyridyl]-5-[(trifluoromethyl)sulfonyl]benzo[d] Oxazosulfyl.

[0143] Among these, considering ease of availability, the preferred formulations are acynonapyr / tebufenpyrad, acynonapyr / hexythiazox, acynonapyr / fenpyroximate, acynonapyr / propargite, acynonapyr / tolfenpyrad, acynonapyr / abamectin, acynonapyr / etoxazole, acynonapyr / spinosad, and acynonapyr / isocyanate. Isoxathion, acetamiprid, fipronil, tralomethrin, BT agent, buprofezin, cyromazine, tebufenozide, fulbendiamide, pyridaben Pyridalyl, acynonapyr / lufenuron, acynonapyr / flonicamid, acynonapyr / chlorfenapyr, acynonapyr / indoxacarb, acynonapyr / diafenthiuron, acynonapyr / thiocyclam, acynonapyr / emamectin-benzoate, acynonapyr / pyridazine.

[0144] The combination of acynonapyr / hexythiazox and acynonapyr / etoxazole is particularly preferred.

[0145] The mass ratio of compound A to compound B (compound A / compound B) used in the method of the present invention is not particularly limited, but is preferably 200 / 1 to 1 / 200, more preferably 1 / 1 to 1 / 200, and even more preferably 1 / 1 to 1 / 10.

[0146] It is particularly preferred to apply the medication at a mass ratio that exhibits a synergistic effect. The synergistic effect can be confirmed by the Colby method described later.

[0147] In the method of the present invention, compound A can be applied first, followed by compound B, or compound B can be applied first, followed by compound A, or compound A and compound B can be applied simultaneously, or compound A and compound B can be mixed and then applied.

[0148] In the method of this invention, the active ingredient (hereinafter referred to as compound C) contained in other agents such as fungicides, plant growth regulators, synergists, fertilizers, soil conditioners, and animal feeds described later may also be applied together with compounds A and B. The order of application is not particularly limited; for example, it may be applied in the following order: compound A, compound B, compound C; compound A, compound C, compound B; compound C, compound A, compound B; compound C, compound B, compound A; compound B, compound C, compound A; compound B, compound A, compound C; or compound A, compound B, compound A, compound C. Alternatively, compounds A, B, and C may be applied simultaneously.

[0149] The application of compound A can be carried out in its original form, preferably in a composition containing compound A (pharmaceutical composition A). The application of compound B can be carried out in its original form, preferably in a composition containing compound B (pharmaceutical composition B). The application of compound C can be carried out in its original form or in a composition containing compound C (pharmaceutical composition C).

[0150] Pharmaceutical compositions A, B, and C can each be formulated into known forms. Through formulation, they can be produced in forms commonly used for pesticides or veterinary drugs, such as wettable powders, granules, powders, tablets, emulsions, water-soluble powders, suspensions, water-dispersible granules, flowable formulations, microcapsules, aerosols, sprays, mists, heated vaporizers, fumigants, and poison baits. Additionally, compounds A, B, and / or C can be impregnated into substrates such as porous ceramic plates, nonwoven fabrics, and paper.

[0151] The amount of compound A contained in pharmaceutical composition A, the amount of compound B contained in pharmaceutical composition B, and the amount of compound C contained in pharmaceutical composition C are not particularly limited, and are generally 0.1 to 80% by mass relative to pharmaceutical composition A, pharmaceutical composition B, and pharmaceutical composition C, respectively. The contents of compound A, compound B, and compound C in pharmaceutical compositions A, B, and C having dosage forms such as emulsions, liquids, wettable powders (e.g., water-dispersible granules), aqueous suspensions, or microemulsions are preferably 1 to 80% by mass, more preferably 10 to 50% by mass, respectively, relative to pharmaceutical compositions A, B, and C. The contents of compound A, compound B, and compound C in pharmaceutical compositions A, B, and C having dosage forms such as oils or powders are preferably 0.1 to 50% by mass, more preferably 0.1 to 20% by mass, respectively, relative to pharmaceutical compositions A, B, and C. The contents of compound A, compound B, and compound C in pharmaceutical compositions A, B, and C having dosage forms such as granules, tablets, or large granules are preferably 0.5 to 50% by mass, more preferably 0.5 to 10% by mass, respectively, relative to pharmaceutical compositions A, B, and C.

[0152] Pharmaceutical compositions A, B, and C may contain, in addition to compounds A, B, and C, liquid media, substrates, additives, and / or carriers as described below.

[0153] When compound A and compound B (and compound C as needed) are applied simultaneously, it is preferable to prepare a composition comprising compound A and compound B (and compound C as needed) (the pest control composition of the present invention) and use the composition.

[0154] The total amount of compound A and compound B (and compound C, if desired) contained in the pest control composition of the present invention varies slightly depending on the formulation, and is generally 0.1 to 80% by mass relative to the pest control composition. In pest control compositions having formulations such as emulsions, liquids, wettable powders (e.g., water-dispersible granules), aqueous suspensions, or microemulsions, the total content of compound A and compound B (and compound C, if desired) relative to the pest control composition is preferably 1 to 80% by mass, more preferably 10 to 50% by mass. In pest control compositions having formulations such as oils or powders, the total content of compound A and compound B (and compound C, if desired) relative to the pest control composition is preferably 0.1 to 50% by mass, more preferably about 0.1 to 20% by mass. The total content of compound A and compound B (and compound C as needed) in the pest control composition having dosage forms such as granules, tablets, and large granules is preferably 0.5 to 50% by mass relative to the pest control composition, more preferably 0.5 to 10% by mass.

[0155] In the pest control composition of the present invention, the mass ratio of compound A to compound B (compound A / compound B) is not particularly limited, but is preferably 200 / 1 to 1 / 200, more preferably 1 / 1 to 1 / 200, and even more preferably 1 / 1 to 1 / 10. It is particularly preferred that the compound A contains a mass ratio that exhibits a synergistic effect. The synergistic effect can be confirmed by the Colby method described later.

[0156] In addition to compounds A, B, and C, the pest control composition of the present invention may also contain a liquid medium, a substrate, additives, and / or a carrier. The liquid medium, substrate, additives, and / or carriers used in the present invention may be appropriately selected from conventionally known substances depending on the formulation.

[0157] Examples of additives and carriers that can be used in solid dosage forms include plant-based powders such as soybean flour and wheat flour, mineral micro-powders such as diatomaceous earth, apatite, gypsum, talc, bentonite, pyrophyllite, and clay, and organic and inorganic compounds such as sodium benzoate, urea, and mirabilite.

[0158] Examples of liquid media that can be used in liquid formulations include kerosene, petroleum-based aromatic hydrocarbons such as xylene, cyclohexane, cyclohexanone, dimethylformamide, dimethyl sulfoxide, alcohols, acetone, trichloroethylene, methyl isobutyl ketone, mineral oil, vegetable oil, and water.

[0159] Examples of carriers that can be used when formulations are made into propellants include butane gas, LPG, dimethyl ether, and carbon dioxide.

[0160] Examples of bait base materials that can be used include grain flour, vegetable oil, sugar, crystalline cellulose, and other bait ingredients; antioxidants such as butylated hydroxytoluene and nordihydroguaiaric acid; preservatives such as dehydroacetic acid; anti-ingestion agents such as chili powder to prevent children or pets from accidentally ingesting the bait; and insect-attracting spices such as cheese flavoring and onion flavoring.

[0161] Surfactants can be used as additives. Examples of surfactants include nonionic surfactants such as alkylphenyl ethers with added polyoxyethylene, alkyl ethers with added polyoxyethylene, higher fatty acid esters with added polyoxyethylene, sorbitan higher fatty acid esters with added polyoxyethylene, and tristyrylphenyl ethers with added polyoxyethylene; sulfate salts of alkylphenyl ethers with added polyoxyethylene; alkylbenzene sulfonates; sulfate salts of higher alcohols; alkylnaphthalene sulfonates; polycarboxylate salts; lignin sulfonates; formaldehyde condensates of alkylnaphthalene sulfonates; and isobutylene-maleic anhydride copolymers.

[0162] As active ingredients in bactericides, examples include substances exemplified in the FRAC-based classification of bactericide mechanisms of action. Specifically, active ingredients as described below can be cited.

[0163] (1) Inhibitors of nucleic acid biosynthesis:

[0164] (a) RNA polymerase I inhibitors: benalaxyl, benalaxyl-M, furaxyl, metalaxyl, clozylacon, and ofurace.

[0165] (b) Adenosine deaminase inhibitors: bupirimate and ethirimol.

[0166] (c) DNA / RNA synthesis inhibitors: Hymexazol and octhilinone.

[0167] (d) DNA topoisomerase II (helicase) inhibitor: oxolinic acid.

[0168] (2) Mitotic inhibitors and cell division inhibitors:

[0169] (a) β-Tubulin polymerization inhibitors: benomyl, carbendazim, chlorfenazole, fuberidazole, thiophanate-methyl, diethofencarb, zoxamide, ethaboxam.

[0170] (b) Cell division inhibitor: pencycuron.

[0171] (c) Delocalization inhibitor of spectrin-like protein: fluopicolide.

[0172] (3) Respiratory depressants:

[0173] (a) Complex I NADH oxidoreductase inhibitor: diflumetorim.

[0174] (b) Complex II succinate dehydrogenase inhibitors: benodanil, flutolanil, mepronil, isofetamide, fluopyram, fenfuram, frumecyclox, carboxin, tifluzamide, benzovindiflupyr, bixafen, fluxapyroxad, furamepyr, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid.

[0175] (c) Complex III: Cytochrome bc1 (ubiquinone oxidase) Qo (cyt b gene) inhibitors: azoxystrobin, cumoxystrobin, cumethoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, piraoxystrobin, piraclostrobin, pirametostrobin, triclopyricarb, kresoxim-methyl, trifloxystrobin, dimoxystrobin, fenaminestrobin, metominostrobin, orysastrobin Famoxadone, fluoxastrobin, fenamidon, and pyribencarb.

[0176] (d) Complex III: Inhibitors of ubiquinone reductase Qi site: cyazofamid and amisulbrom.

[0177] (e) Oxidative phosphorylation uncoupling substances: meptyldinocap, fluazinam, ferimzone.

[0178] (f) ATP production inhibitor: silthiofam.

[0179] (g) Complex III: Ubiquinone reductase (Qo site, marker-binding subsite) inhibitor: ametoctradin.

[0180] (4) Inhibitors of amino acid and protein synthesis

[0181] (a) Methionine biosynthesis (cgs gene) inhibitors: andoprim, cyprodinil, mepanipyrim.

[0182] (b) Protein synthesis inhibitors: kasugamycin, kasugamycin hydrochloride, streptomycin, oxytetracycline.

[0183] (5) Signal transduction inhibitors:

[0184] (a) Signal transduction inhibitors: quinoxyfen and proquinazid.

[0185] (b) MAP-histidine kinase (os-2, HOG1) inhibitors in osmolarity signal transduction: fenpiclonil and fludioxonil.

[0186] (c) MAP-histidine kinase (os-1, Daf1) inhibitors in osmolarity signal transduction: chlozolinate, iprodione, and procymidone.

[0187] (6) Inhibitors of lipid and cell membrane synthesis:

[0188] (a) Phospholipid biosynthesis and methyltransferase inhibitors: edifenphos, iprobenfos, isoprothiolane.

[0189] (b) Lipid peroxidizers: biphenyl, dichloran, quintozene, tetrachloronitrobenzene, tolclofos-methyl, etridiazole.

[0190] (c) Substances that act on the cell membrane (substances that act on the cell membrane and exert their effects by causing leakage of cell contents): iodocarb, propamocarb, propamocarb-hydrochloride, propamocarb-focetylate, and prothiocarb.

[0191] (d) Microorganisms that disrupt the cell membrane of pathogens: Bacillus subtilis, Bacillus subtilis strain QST713, Bacillus subtilis strain FZB24, Bacillus subtilis strain MBI600, and Bacillus subtilis strain D747.

[0192] (e) Substances that disrupt cell membranes: Melaleuca alternifolia (tea tree) extract.

[0193] (f) Oxathiapiprolin, an inhibitor of oxosterol-binding proteins.

[0194] (7) Inhibitors of sterol biosynthesis in cell membranes:

[0195] (a) Inhibitors of C14 demethylase (erg11 / cyp51) in sterol biosynthesis: triforine, pyrisoxazole, fenarimol, flurprimidol, nuarimol, imazalil, and imazalil sulfate. Imidazole (oxpoconazole), pefurzoate, prochloraz, triflumizole, viniconazole, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flut... (The following are listed as examples of antibiotics:) riafol, fluconazole, fluconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, fluquinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, voriconazole.

[0196] (b) Inhibitors of Δ14 reductase and Δ8→Δ7-isomerase (erg24, erg2) in sterol biosynthesis: aldimorph, dodemorph, dodemorph acetate, fenpropimorph, tridemorph, fenpropidin, piperalin, and spiroxamine.

[0197] (c) 3-keto reductase (erg27) inhibitors in C4 demethylation of sterol biosynthesis system: fenhexamid and fenpyrazamine.

[0198] (d) Squalene epoxygenase (erg1) inhibitors in the sterol biosynthesis system: pyribaticarb, naftifen, and terbinafine.

[0199] (8) Cell wall synthesis inhibitors

[0200] (a) Chitin synthase inhibitors: polyoxin and polyoxorim.

[0201] (b) Cellulose synthase inhibitors: dimethomorph, flumorph, pyrimorph, benthiavalicarb, iprovalicarb, valifenalate, mandipropamid.

[0202] (9) Substances that inhibit melanin biosynthesis

[0203] (a) Reductase inhibitors in melanin biosynthesis: fthalide, pyroquilon, and tricyclazole.

[0204] (b) Dehydrating enzyme inhibitors of melanin biosynthesis: diclocymet and fenoxanil.

[0205] (c) Polyketide synthase inhibitors in melanin biosynthesis: tolprocarb.

[0206] (10) The active ingredient of the resistance inducer in the host plant:

[0207] Probenazole, tiadinil, isotianil, laminarin, and Reynoutria sachalinensis extract.

[0208] (11) Substances with unknown effects: cymoxanil, fosetyl-aluminum, phosphoric acid (phosphate), triazine, flusulfamide, cyflufenamid, metrafenone, pyriofenone, dodine, dodine free base, flutianil.

[0209] (12) Substances with multiple action sites: copper (copper salt), Bordeaux mixture, copper hydroxide, copper naphthalate, copper oxide, copper oxychloride, copper sulfate, sulfur, sulfur products, calcium polysulfide Polysulfide, ferbam, mancozeb, maneb, mancopper, metiram, polycarbamate, propineb, thiram, ziram, captan, captahol, folpet, chlorotalonil, dichlofluanid, tolylfluanid, guazatine, iminoctadine triacetate, iminoctadine trialbesilate, anilazine, dithianon, quinomethionate, fluorimide.

[0210] (13) Other substances: DBEDC, fluorofolpet, guazatine acetate, bis(8-quinolinolato)copper(II) (8-hydroxyquinoline), propamidine, cyprofuram, agrobacterium, bethoxazin, diphenylamine, methyl isothiocyanate (MITC), capsaicin, cufraneb, cyprosulfamide, debacarb, dichlorophen, flumetover, fosetyl-calcium, fosetyl-sodium, irumamycin, nitrothalonil isopropyl, oxamocarb, propanosine-sodium, pyrrolnitrin, tebufloquin, tolnifanide, zaliramide, Algophase, amicathiazol, metiram zinc, trichloroamide, uniconazole, oxyfenthiin, picarbutrazox, quinomethionate, 2-[(7,8-difluoro-2-methyl-3-quinolinyl)oxy]-6-fluoro-α,α-dimethylbenzyl alcohol.

[0211] The following substances are examples of active ingredients that can be used as plant growth regulators.

[0212] Kinetin, benzylaminopurine, 1,3-diphenylurea, forchlorfenuron, thidiazuron, chlorfenuron, dihydrozeatin, gibberellin A, gibberellin A4, gibberellin A7, gibberellin A3, 1-methylcyclopropane, N-acetylaminoethoxyvinyl glycine (also known as avidin), aminooxyacetate, silver nitrate, cobalt chloride chloride), IAA, 4-CPA, cloprop, 2,4-D, MCPB, indole-3-butyrate, dichlorprop, phenothiol, 1-naphthyl acetamide, ethychlozate, salicylic acid, methyl salicylate, (-)-jasmonicacid, methyl jasmonic acid Jasmonate, (+)-strigol, (+)-deoxystrigol, (+)-orobanchol, (+)-sorgolactone, 4-oxo-4-(2-phenylethyl)aminobutyric acid, ethephon, chlormequat, mepiquatchloride, benzyladenine, and 5-aminolevulinic acid.

[0213] There are no particular restrictions on the application methods of pesticide compositions A, B, and C. For example, pesticide compositions in the form of wettable powder, emulsion, flowable formulation, water-soluble powder, and water-dispersible granules can be applied by diluting the pesticide composition with water to a specified concentration to prepare a solution, suspension, or emulsion and dispersing it on plants or soil. Pesticide compositions in the form of powder or granules can be applied by dispersing the pesticide composition on plants or soil. Pesticide compositions in the form of poison bait, acaricide tablets, etc., can be applied by placing or hanging the pesticide composition in the desired location. Pesticide compositions in the form of aerosols, fumigants, etc., can be applied using a sprayer or similar device.

[0214] Furthermore, it can be administered using well-known veterinary methods (topical, oral, non-oral, or subcutaneous administration). Examples of veterinary methods include oral administration to animals via tablets, capsules, or feed mixing; administration via soaking solutions, suppositories, or injections (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.); topical administration of oily or aqueous liquid preparations via spraying, pouring, or spotting; and topical administration by mixing ectoparasite control agents into resin, shaping the mixture into suitable forms such as collars or ear tags, and wearing them on the animal.

[0215] There is no particular limit to the amount applied to the target organism, and it can be appropriately set according to the type of organism being controlled and the timing of control. For example, to control mites parasitizing livestock such as cattle and pigs, and pets such as dogs and cats, it can be applied at a ratio of 0.01 to 1000 mg of compound A and compound B per 1 kg of the host animal.

[0216] Examples of plants to be applied include cereals; vegetables; root vegetables; bulbs; fruit trees, trees such as tea, coffee, and cocoa trees; forage grasses; gramineous plants; flowers; foliage plants; and cotton. The plants to be applied are not limited to original species, varieties, improved varieties, cultivars, mutants, hybrids, or genetically modified organisms (GMOs). In the method of this invention, the application can be made to the entire plant or to a part of the plant, such as leaves, stems, petioles, flowers, buds, fruits, seeds, shoots, roots, tubers, root tubers, seedlings, or cuttings. To control various agricultural pests and mites, seed treatment, foliar application, soil application, and water surface application can be used.

[0217] In addition, as objects to be applied, examples include pet animals such as dogs and cats that can serve as hosts for ectoparasites; pet birds; livestock such as cattle, horses, pigs, and sheep; warm-blooded animals such as poultry; and insects such as bees, stag beetles, and rhinoceros beetles.

[0218] There are no particular limitations on the pests that can be controlled by the method of this invention. Examples include sanitary pests, stored grain pests, clothing and food pests, house pests, parasites, and crop pests. Mites are among these.

[0219] The pest control method of the present invention can be carried out throughout the entire developmental stage of the pest being controlled. For example, the method of the present invention can be applied to eggs, nymphs, larvae, pupae, and adults.

[0220] The following are examples of pests that are targeted for control.

[0221] (1) Butterflies or moths of the order Lepidoptera

[0222] For example,

[0223] (1-a) Moths of the family Arctiidae, such as the fall white moth (Hyphantria cunea) and the pesky light moth (Lemyra imparilis);

[0224] (1-b) Moths of the family Bucculatricidae, such as Bucculatrix pyrivorella;

[0225] (1-c) Peach fruit borer (Carposina sasakii) and other fruit borers (Carposinidae);

[0226] (1-d) The genera *Diaphania*, such as *Diaphania indica* and *Diaphania nitidalis*; the genera *Ostrinia*, such as *Ostrinia furnacalis*, *Ostrinianubilalis*, and *Ostrinia scapulalis*; and the genera *Chilo suppressalis*, *Cnaphalocrocis medinalis*, *Conogethes punctiferalis*, *Diatraea grandiosella*, and *Glyphodes*. Other moths belonging to the family Crambidae, such as the cabbage moth (Hellulaundalis) and the English bluegrass moth (Parapediasiateterrella);

[0227] (1-e) Moths of the family Gelechiidae, including the sweet potato moth (Helcystogramma triannulella), cotton bollworm (Pectinophoragossypiella), potato tuber moth (Phthorimaea operculella), and wheat moth (Sitotroga cerealella);

[0228] (1-f) Moths of the Geometridae family, such as Ascotis selenaria;

[0229] (1-g) Moths of the family Gracillariidae, such as the tea leafminer (Caloptilia theivora), the citrus leafminer (Phyllocnistis citrella), and the golden leafminer (Phyllonorycter ringoniella);

[0230] (1-h) Butterflies of the family Hesperiidae: for example, the straight-striped rice skipper (Parnara guttata);

[0231] (1-i) Moths of the family Lasiocampidae: for example, tent caterpillar (Malacosoma neustria);

[0232] (1-j) Moths of the family Lymantriidae: for example, Lymantria dispar and Lymantria monacha of the genus Lymantria spp.;

[0233] Other genera include the tea hairy caterpillar (Euproctis pseudoconspersa) and the spiny tussock moth (Orgyia thyellina);

[0234] (1-k) Moths of the family Lyonetiidae: for example, the peach leafminer (Lyonetia clerkella) and the silver leafminer (Lyonetia prunifoliella malinella) of the genus Lyonetia spp.;

[0235] (1-l) Moths of the family Noctuidae: for example, Spodoptera depravata, Spodoptera eridania, Spodoptera exigua, Spodoptera frugiperda, Spodoptera eridania, and Spodoptera litura of the genus Spodoptera spp.

[0236] The genus *Autographa* includes the silver-striped noctuid moth (*Autographa gamma*) and the black-spotted noctuid moth (*Autographa nigrisigna*).

[0237] Cutworm (Agrotis ipsilon) and turnip moth (Agrotissegetum) of the genus Agrotis spp.;

[0238] The cotton bollworm (Helicoverpa armigera), the tobacco bollworm (Helicoverpa assulta), and the grain bollworm (Helicoverpa zea) belong to the genus Helicoverpa spp.;

[0239] The cotton bollworm (Heliothis armigera) and the tobacco bud borer (Heliothis virescens) belong to the genus Heliothis spp.;

[0240] Other genera include the white-spotted armyworm (Aedia leucomelas), the silver-striped armyworm (Ctenoplusia agnata), the leaf-killing armyworm (Eudocima tyrannus), the cabbage armyworm (Mamestra brassicae), the armyworm (Mythimnaseparata), the rice stem borer (Naranga aenescens), the pine cutter moth (Panolis japonica), the field armyworm (Peridromasaucia), the soybean armyworm (Pseudoplusia includens), and the powdery armyworm (Trichoplusia ni).

[0241] (1-m) Moths of the family Nolidae: for example, the cottony fruit moth (Earias insulana);

[0242] (1-n) Butterflies of the family Pieridae: for example, the European white butterfly (Pieris brassicae) and the striped white butterfly (Pieris rapae crucivora) of the genus Pieris spp.;

[0243] (1-o) Moths of the family Plutellidae: for example, the onion moth (Acrolepiopsis sapporensis) and the suzuki moth (Acrolepiopsis suzukiella) of the genus Acrolepiopsis spp.;

[0244] Other genera of diamondback moth (Plutella xylostella);

[0245] (1-p) Moths of the family Pyralidae: for example, the corn borer (Cadra cautella), the small corn stalk borer (Elasmopalpus lignosellus), the bean pod borer (Etiella zinckenella), and the large wax borer (Galleriamellonella);

[0246] (1-q) Moths of the family Sphingidae: for example, the tomato hawk moth (Manduca quinquemaculata) and the tobacco hawk moth (Manduca sexta) of the genus Manduca spp.;

[0247] (1-r) Moths of the family Stathmopodidae: for example, Stathmopodamasinissa;

[0248] (1-s) Moths of the family Tineidae: for example, the clothes moth (Tinea translucens);

[0249] (1-t) Moths of the family Tortricidae: for example, the tea leafroller (Adoxophyes honmai) and the apple leafroller (Adoxophyes orana) of the genus Adoxophyes spp.;

[0250] The pear yellow leafroller (Archips breviplicanus) and the apple yellow leafroller (Archips fuscocupreanus) belong to the genus Archipelago.

[0251] Other genera include the spruce bud roller (Choristoneura fumiferana), codling moth (Cydiapomonella), privet leaf roller (Eupoecilia ambiguella), pear fruit borer (Grapholitha molesta), yellow leaf roller (Homona magnanima), soybean fruit borer (Leguminivora glycinivorella), grape flower-winged leaf roller (Lobesia botrana), bean leaf roller (Matsumuraeses phaseoli), apple brown leaf roller (Pandemisheparana), and grape long-bearded leaf roller (Sparganothis pilleriana);

[0252] (1-u) Moths of the family Yponomeutidae: for example, the silver apple moth (Argyresthia conjugella).

[0253] (2) Thysanoptera pests

[0254] (2-a) Thrips of the family Phlaeothripidae: for example, persimmon thrips (Ponticulothrips diospyrosi);

[0255] (2-b) Thripidae: for example, the rice thrips (Frankliniella intonsa) and the western thrips (Frankliniella occidentalis) of the genus Frankliniella spp.;

[0256] The genus *Thrips* includes the palm thrips (*Thrips palmi*) and the tobacco thrips (*Thrips tabaci*).

[0257] Other genera include the greenhouse thrips (Heliothrips haemorrhoidalis) and the tea thrips (Scirtothripsdorsalis).

[0258] (3) Pests of the order Hemiptera

[0259] (3-A) Archaeorhynchus

[0260] (3-Aa) Planthoppers (Delphacidae): for example, gray planthopper (Laodelphax striatella), brown planthopper (Nilaparvata lugens), sugarcane flat-horned planthopper (Perkinsiella saccharicida), white-backed planthopper (Sogatella furcifera).

[0261] (3-B) Clypeorrhyncha

[0262] (3-Ba) Cicadidae: for example, the potato green leafhopper (Empoasca fabae), the Japanese green leafhopper (Empoasca nipponica), the small green leafhopper (Empoasca onukii), and the sakai green leafhopper (Empoasca sakaii) of the genus Empoasca spp.

[0263] Other genera include the grape leafhopper (Arboridia apicalis), the black-breasted two-chambered leafhopper (Balcluthasaltuella), the two-spotted leafhopper (Epiacanthus stramineus), the black-fronted two-forked leafhopper (Macrostelesstriifrons), and the black-tailed leafhopper (Nephotettix cinctinceps).

[0264] (3-C) Heteroptera

[0265] (3-Ca) Alydidae: for example, the spotted stink bug (Riptortus clavatus);

[0266] (3-Cb) Coreidae: for example, Cletus punctiger and Leptocorisa chinensis;

[0267] (3-Cc) Lygaeidae: for example, Blissus leucopterus, Cavelerius saccharivorus, Togo hemipterus;

[0268] (3-Cd) Miridae: for example, Japanese jumping mirid bug (Halticus insularis), American pasture mirid bug (Lygus lineolaris), cotton mirid bug (Psuedatomoscelis seriatus), Siberian narrow mirid bug (Stenodema sibiricum), red-striped fiber mirid bug (Stenotus rubrovittatus), red-bearded mirid bug (Trigonotylus caelestialium);

[0269] (3-Ce) Pentatomidae: for example, the black-bearded green bug (Nezara antennata) and the rice green bug (Nezara viridula) of the genus Nezara spp.;

[0270] The genus *Eysarcoris* includes the Northern Two-Starred Bug (*Eysarcoris aeneus*), the Japanese Two-Starred Bug (*Eysarcoris lewisi*), and the Broad Two-Starred Bug (*Eysarcoris ventralis*).

[0271] Other genera include the fine-haired bug (Dolycoris baccarum), the wrinkled vegetable bug (Eurydema rugosum), the green bug (Glaucias subpunctatus), the tea-winged bug (Halyomorpha halys), the wall bug (Piezodorus hybneri), the black bug (Plautia crossota), and the rice black bug (Scotinophora lurida);

[0272] (3-Cf) Pyrrhocoridae: for example, Dysdercus cingulatus;

[0273] (3-Cg) Rhopalidae: e.g., Rhopalus msculatus;

[0274] (3-Ch) Scutelleridae: e.g., Eurygaster integriceps;

[0275] (3-Ci) Tingidae: for example, Stephanitis nashi.

[0276] (3-D) Sternorrhyncha

[0277] (3-Da) Aphids of the family Adelgidae: for example, the larch aphid (Adelges laricis);

[0278] (3-Db) Aleyrodidae: for example, the silver leaf whitefly (Bemisia argentifolii) and the tobacco whitefly (Bemisia tabaci) of the genus Bemisia spp.;

[0279] Other genera include the black spiny whitefly (Aleurocanthus spiniferus), the citrus whitefly (Dialeurodescitri), and the greenhouse whitefly (Trialeurodes vaporariorum);

[0280] (3-Dc) Aphididae: For example, the genus Aphis spp., including the bean aphid (Aphis craccivora), black bean aphid (Aphis fabae), strawberry root aphid (Aphis forbesi), cotton aphid (Aphis gossypii), apple aphid (Aphis pomi), elder aphid (Aphis sambuci), and spiraecola aphid;

[0281] The genus *Rhopalosiphum* includes the maize aphid (*Rhopalosiphum maidis*) and the cereal aphid (*Rhopalosiphum padi*).

[0282] The rose apple aphid (Dysaphis plantaginea) and the radicola aphid (Dysaphis radicola) belong to the genus Dysaphis spp.

[0283] The genus *Macrosiphum* includes the wheat avenae and the euphorbiae.

[0284] The genus *Myzus* includes the plum aphid (*Myzus cerasi*), the peach aphid (*Myzus persicae*), and the yellow variegated aphid (*Myzus varians*).

[0285] Other genera include the pea aphid (Acyrthosiphon pisum), the eggplant aphid (Aulacorthum solani), the marigold plum aphid (Brachycaudus helichrysi), the cabbage aphid (Brevicoryne brassicae), the strawberry aphid (Chaetosiphon fragaefolii), the peach aphid (Hyalopterus pruni), the chamomile aphid (Hyperomyzus lactucae), the turnip aphid (Lipaphis erysimi), the vetch aphid (Megoura viciae), the wheat aphid (Metopolophium dirhodum), the lettuce aphid (Nasonovia ribis-nigri), the finger aphid (Phorodon humuli), the wheat aphid (Schizaphis graminum), the wheat aphid (Sitobion avenae), and the orange aphid (Toxoptera aurantii);

[0286] (3-Dd) Coccidae: for example, the horned wax scale (Ceroplastes ceriferus) and the red wax scale (Ceroplastes rubens) of the genus Ceroplastes spp.;

[0287] (3-De) Species of the family Diaspididae: Species of the genus Pseudaulacaspis spp., including the mulberry scale (Pseudaulacaspis pentagona) and the plum scale (Pseudaulacaspis prunicola);

[0288] The genus *Unaspis* includes the euonymi scale and the yanonensis scale.

[0289] Other genera include the red round scale (Aonidiella aurantii), the Saint Jones shield scale (Comstockaspisperniciosa), the tea shield scale (Fiorinia theae), and the peony netted shield scale (Pseudaonidia paeoniae);

[0290] (3-Df) Margarodidae: for example, Drosicha corpulenta and Icerya purchasi;

[0291] (3-Dg) Phyllostachys: for example, grape phylloxera (Viteus vitifolii);

[0292] (3-Dh) Pseudococcidae: for example, the citrus mealybug (Planococcus citri) and the Japanese mealybug (Planococcus kuraunhiae) of the genus Planococcus spp.

[0293] Other genera include the Lycoris solani mealybug and the Comstock mealybug;

[0294] (3-Di) Psyllidaceae: for example, apple psyllid (Psyllamali) and pear psyllid (Psylla pyrisuga) of the genus Psylla spp.;

[0295] Other genera of citrus psyllids (Diaphorina citri).

[0296] (4) Pests of the order Coleoptera

[0297] (4-a) Anobiidae: for example, the tobacco beetle (Lasioderma serricorne);

[0298] (4-b) Attelabidae: for example, pear leaf curler (Byctiscus betulae) and Japanese apple beetle (Rhynchites heros);

[0299] (4-c) Bostrichidae: for example, Lyctus brunneus;

[0300] (4-d) Brentidae: for example, the sweet potato weevil (Cylas formicarius);

[0301] (4-e) Buprestidae: for example, the pear narrow jewel beetle (Agrilus sinuatus);

[0302] (4-f) Cerambycidae: for example, Anoplophora malasiaca, Monochama alternatus, Psacothea hilaris, Xylotrechus pyrrhoderus;

[0303] (4-g) Chrysomelidae: for example, the pea weevil (Bruchus pisorum) and broad bean weevil (Bruchus rufimanus) of the genus Bruchus spp.;

[0304] The genus *Diabrotica* spp. includes the northern corn root beetle (*Diabrotica barberi*), the eleven-spotted cucumber beetle (*Diabrotica undecimpunctata*), and the corn root firefly beetle (*Diabrotica virgifera*).

[0305] The genus *Phyllotreta* includes the soybean flea beetle *Phyllotreta nemorum* and the yellow-striped flea beetle *Phyllotreta striolata*.

[0306] Other genera include the cucumber beetle (Aulacophora femoralis), bean weevil (Callosobruchuschinensis), beet beetle (Cassida nebulosa), beet flea beetle (Chaetocnema concinna), potato beetle (Leptinotarsa ​​decemlineata), rice leaf beetle (Oulema oryzae), and narrow-throated flea beetle (Psylliodes angusticollis);

[0307] (4-h) Coccinellidae: for example, the Mexican bean ladybug (Epilachna varivestis) and the twenty-eight-spotted ladybug (Epilachna vigintioctopunctata) of the genus Epilacellidae.

[0308] (4-i) Culculionidae: for example, the cotton boll weevil (Anthonomus grandis) and the pear weevil (Anthonomus pomorum) of the genus Anthonomus spp.;

[0309] The genus *Sitophilus* spp. includes the grain weevil *Sitophilus granarius* and the maize weevil *Sitophilus zeamais*; other genera include the rice weevil *Echinocnemus squameus*, the West Indian sweet potato weevil *Euscepespostfasciatus*, the European pine bark weevil *Hylobius abietis*, the alfalfa leaf weevil *Hypera postica*, the rice water weevil *Lissohoptrus oryzophilus*, the grape black weevil *Otiorhynchus sulcatus*, the pea root nodule weevil *Sitona lineatus*, and the predatory grain weevil *Sphenophorus venatus*.

[0310] (4-j) Elateridae: for example, the brown wireworm (Melanotus fortnumi) and the comb beetle (Melanotus tamsuyensis) of the genus Melanotus spp.;

[0311] (4-k) Nitidulidae: for example, Epuraea domina;

[0312] (4-l) Scarabaeidae: for example, the copper beetle (Anomala cuprea) and red copper beetle (Anomala rufocuprea) of the genus Anomala spp.; and other genera such as the golden beetle (Cetoniaaurata), the small blue-flowered beetle (Gametis jucunda), the yellow-breasted beetle (Heptophylla picea), the large chestnut-browed beetle (Melolontha melolontha), and the Japanese beetle (Popillia japonica);

[0313] (4-m) of the family Scolytidae: for example, the spruce bark beetle (Ips typographus);

[0314] (4-n) Staphylinidae: for example, Paederus fuscipes;

[0315] (4-o) Tenebrionidae: for example, mealworm (Tenebrio molitor) and red flour beetle (Tribolium castaneum);

[0316] (4-p) of Trogossitidae: for example, the giant grain beetle (Tenebroides mauritanicus).

[0317] (5) Pests of the order Diptera

[0318] (5-A) Brachycera

[0319] (5-Aa) Agromyzidae: for example, Liriomyza bryoniae, Liriomyza chinensis, Liriomyza sativae, and Liriomyza trifolii, all belonging to the genus Liriomyza spp.

[0320] Other genera include the pea leafminer (Chromatomyia horticola) and the Japanese rice leafminer (Agromyzaoryzae);

[0321] (5-Ab) Anthomyiidae: for example, Deliaplatura and Delia radicum of the genus Delia spp.; and Pegomya cunicularia of other genera.

[0322] (5-Ac) Drosophilidae: for example, Drosophila melanogaster and Drosophila suzukii from the genus Drosophila spp.

[0323] (5-Ad) Water flies of the family Ephydridae: for example, rice leaf miner (Hydrellia griseola);

[0324] (5-Ae) Psilidae: for example, carrot stem fly (Psila rosae);

[0325] (5-Af) Tephritidae: for example, Bactrocera cucurbitae and Bactrocera dorsalis, belonging to the genus Bactrocera spp.;

[0326] The cherry fruit fly (Rhagoletis cerasi) and the apple fruit fly (Rhagoletis pomonella) belong to the genus Rhagoletis spp.;

[0327] Other genera include the Mediterranean fruit fly (Ceratitis capitata) and the olive fruit fly (Dacus oleae).

[0328] (5-B) Nematocera

[0329] (5-Ba) Cecidomyiidae: for example, Asphondylia yushimai, Contarinia sorghicola, Mayetiola destructor, and Sitodiplosis mosellana.

[0330] (6) Pests of the order Orthoptera

[0331] (6-a) Acrididae: for example, the South American desert locust (Schistocerca americana) and the desert locust (Schistocerca gregaria) of the genus Schistocerca spp.;

[0332] Other genera include the Australian locust (Chortoicetes terminifera), the Moroccan locust (Dociostaurus maroccanus), the East Asian migratory locust (Locusta migratoria), the brown migratory locust (Locustanapardalina), the red-winged locust (Nomadacris septemfasciata), and the small-winged rice locust (Oxya yezoensis).

[0333] (6-b) Gryllidae: for example, house cricket (Acheta domestica), yellow-faced oil cricket (Teleogryllus emma);

[0334] (6-c) of the family Gryllotalpidae: for example, the oriental mole cricket (Gryllotalpa orientalis);

[0335] (6-d) Tettigoniidae: for example, the greenhouse cricket (Tachycines asynamorus).

[0336] (7) Acari (ticks and mites)

[0337] (7-A) Acaridida, a suborder of flour mites belonging to the order Astigmata.

[0338] (7-Aa) Mites of the family Acaridae: for example, Rhizoglyphus echinopus and Rhizoglyphus robini of the genus Rhizoglyphus spp.;

[0339] The genus *Tyrophagus* includes *Tyrophagus neiswanderi*, *Tyrophagus perniciosus*, *Tyrophagus putrescentiae*, and *Tyrophagus similis*.

[0340] Other genera include the rough-legged flour mite (Acarus siro), the elliptical flour mite (Aleuroglyphus ovatus), and the fungi-eating fungi mite (Mycetoglyphus fungivorus);

[0341] (7-B) Actinedida, a suborder of mites within the order Prostigmata.

[0342] (7-Ba) Mites of the family Tetranychidae: for example, bryobia praetiosa and bryobia rubrioculus of the genus bryobia spp.;

[0343] The genus *Eotetranychus* includes the following species: *Eotetranychus asiaticus*, *Eotetranychus boreus*, *Eotetranychus celtis*, *Eotetranychus geniculatus*, *Eotetranychus kankitus*, *Eotetranychus pruni*, *Eotetranychus shii*, *Eotetranychus smithi*, *Eotetranychus suginamensis*, and *Eotetranychus uncatus*.

[0344] The genus *Oligonychus* includes the following species: *Oligonychus hondoensis*, *Oligonychus ilicis*, *Oligonychus karamatus*, *Oligonychus mangiferus*, *Oligonychus orthius*, *Oligonychus perseae*, *Oligonychus pustulosus*, *Oligonychus shinkajii*, and *Oligonychus ununguis*.

[0345] The genus *Panonychus* includes *Panonychus citri*, *Panonychus mori*, and *Panonychus ulmi*.

[0346] The genus *Tetranychus* spp. includes the following spider mites: *Tetranychus cinnabarinus*, *Tetranychus evansi*, *Tetranychus kanzawai*, *Tetranychus ludeni*, *Tetranychus quercivorus*, *Tetranychus phaselus*, *Tetranychus urticae*, and *Tetranychus viennensis*.

[0347] The genus Aponychus includes the bamboo Aponychus corpuzae and the sycamore Aponychus firmianae.

[0348] The genus *Sasanychus* includes the green spider mite (*Sasanychus akitanus*) and the dwarf green spider mite (*Sasanychus pusillus*).

[0349] The genus *Shizotetranychus* includes *Shizotetranychus celarius*, *Shizotetranychus longus*, *Shizotetranychus miscanthi*, *Shizotetranychus recki*, and *Shizotetranychus schizopus*.

[0350] Other genera of oxalis include the spider mite (Tetranychina harti), the peacock spider mite (Tuckerella pavoniformis), and the Sapporo spider mite (Yezonychus sapporensis);

[0351] (7-Bb) Mites of the family Tenuipalpidae: for example, Brevipalpus lewisi, Brevipalpus obovatus, Brevipalpus phoenicis, Brevipalpus russulus, and Brevipalpus californicus of the genus Brevipalpus spp.;

[0352] The genus *Tenuipalpus* includes the Pacific fine-toothed mite (*Tenuipalpus pacificus*) and the persimmon fine-toothed mite (*Tenuipalpus zhizhilashviliae*).

[0353] Other genera of pineapple leaf mite (Dolichotetranychus floridanus);

[0354] (7-Bc) Mites of the family Eriophyidae: For example, the genus *Aceria* includes *Aceria diospyri*, *Aceria ficus*, *Aceria japonica*, *Aceria kuko*, *Aceria paradianthi*, *Aceriatiyingi*, *Aceria tulipae*, and *Aceria zoysiea*.

[0355] Eriophyes spp. include Eriophyes chibaensis and Eriophyes emarginatae;

[0356] The genus Aculops includes Aculops lycopersici and Aculops pelekassi.

[0357] The genus *Aculus* includes *Aculus fockeui* and *Aculus schlechtendali*.

[0358] Other genera include *Acaphylla theavagrans*, *Calacarus carinatus*, *Colomerus vitis*, *Calepitrimerus vitis*, *Epitrimerus pyri*, *Paraphytoptus kikus*, *Paracalacarus podocarpi*, and *Phyllocotruta citri*.

[0359] (7-Bd) Mites of the family Transonemidae, such as Tarsonemus bilobatus and Tarsonemus waitei of the genus Tarsonemus spp.;

[0360] Other genera include *Phytonemus pallidus* and *Polyphagotarsonemus latus*.

[0361] (7-Be) Mites of the family Pentleidae: for example, the cabbage mite (Penthaleus erythrocephalus) and wheat mite (Penthaleus major) of the genus Pentleus spp.

[0362] External parasites that are targeted for control include those that live on the back, armpits, lower abdomen, and inner thighs of host animals, obtaining nutrients such as blood and dander from the animal for survival, as well as those that fly to the back and buttocks of host animals and obtain nutrients such as blood and dander from the animal for survival. Examples of external parasites include mites, lice, fleas, mosquitoes, hornflies, and flesh flies. Specific examples of external parasites are shown below.

[0363] (1) Mites (Acari)

[0364] Mites belonging to the families Dermanyssidae, Macronyssidae, Laelapidae, Varroidae, Argasidae, Ixodidae, Psoroptidae, Sarcoptidae, Knemidokoptidae, Demodixidae, and Trombiculidae.

[0365] (2) Phthiraptera

[0366] Louses of the Haematopinidae family, lice of the Linognathidae family, bird lice of the Menoponidae family, bird lice of the Philopteridae family, and bird lice of the Trichodectidae family.

[0367] (3) Siphonaptera

[0368] Fleas of the family Pulicidae, such as the canine flea (Ctenocephalides canis) and the cat flea (Ctenocephalides felis) of the genus Ctenocephalides spp.;

[0369] Fleas in the family Tungidae, fleas in the family Ceratophyllidae, and fleas in the family Leptopsyllidae.

[0370] (4) Hemiptera

[0371] Insects of the families Cimicidae, Reduviidae, and Triatominae.

[0372] (5) Pests of the order Diptera

[0373] Mosquitoes (Culicidae), midges (Simuliidae), midges (Ceratopogonidae), horseflies (Tabanidae), flies (Muscidae), tsetse flies (Glossinidae), flesh flies (Sarcophagidae), flies (Hippoboscidae), flies (Calliphoridae), and flies (Oestridae).

[0374] In addition, it is also highly effective in controlling pests with poisonous needles or venom, pests that harm humans and animals, pests that spread various pathogens and bacteria, and pests that cause discomfort (poisonous pests, sanitary pests, unpleasant pests, etc.).

[0375] The following are specific examples.

[0376] (1) Pests of Hymenoptera

[0377] Bees of the families Argidae, Cynipaidae, Diprionidae, Formicidae, Mutillidae, and Vespidae.

[0378] (2) Other pests

[0379] Cockroaches (Blattodea), termites (termite), spiders (Araneae), centipedes (cetipede), millipedes (millipede), crustaceans (crustacea), and temperate bedbugs (Cimex lectularius).

[0380] Although several formulation examples of pharmaceutical compositions have been shown, the additives and proportions should not be limited to these examples and can vary widely. Parts in the formulation examples represent parts by weight. It should be noted that the active ingredient is compound A in pharmaceutical composition A, compound B in pharmaceutical composition B, compound C in pharmaceutical composition C, and compound D in pharmaceutical composition D. Compounds A and B, and compound C as needed, are used in the pest control compositions of the present invention.

[0381] Examples of formulations for agricultural and horticultural use are shown.

[0382] Formulation Example 1 (Wettable Powder)

[0383]

[0384] The above raw materials are mixed evenly and then finely pulverized to obtain a wettable powder with 40% active ingredients.

[0385] Formulation Example 2 (Emulsion)

[0386]

[0387] The above raw materials are mixed and dissolved to obtain an emulsion with 30% active ingredients.

[0388] Formulation Example 3 (Flowable Formulation)

[0389]

[0390] The above raw materials are mixed to obtain a flowable formulation with 30% active ingredient.

[0391] Formulation Example 4 (Flowable Formulation)

[0392]

[0393] The above raw materials are mixed to obtain a flowable formulation with 20% active ingredient.

[0394] Examples of formulations for disease prevention and animal use are shown.

[0395]

[0396] The active ingredient is dissolved in an organic solvent, sprayed onto a carrier, and the solvent evaporates under reduced pressure. These particles can then be mixed with animal feed.

[0397] Formulation Example 6 (Injection)

[0398] 0.1 to 1 part of active ingredient

[0399] Peanut oil balance

[0400] After preparation, the material is sterilized by filtration using a sterilization filter.

[0401] Formulation Example 7 (Pouring Agent)

[0402] 5 parts of active ingredient

[0403] 10 parts myristate

[0404] Isopropanol balance

[0405] Formulation Example 8 (Dotting Agent)

[0406] 10-15 parts of active ingredient

[0407] 10 parts palmitate

[0408] Isopropanol balance

[0409] Formulation Example 9 (Spray)

[0410] 1 part of active ingredient

[0411] 10 parts of propylene glycol

[0412] Isopropanol balance

[0413] Next, the effectiveness of implementing the prevention method of the present invention will be demonstrated through the following test examples.

[0414] [Experimental Example 1]

[0415] Confirmatory efficacy test against two-spotted spider mite (Tetranychus urticae)

[0416] One day before the chemical treatment, inoculate 8 or 10 adult female two-spotted spider mites onto bean leaves placed in a petri dish.

[0417] A flowable formulation containing compound A was diluted with water containing Rabiden 3S diluted 5000 times to prepare a drug solution A containing compound A at twice the concentrations recorded in Tables 1 to 4.

[0418] The formulation containing compound B was diluted with water containing Rabiden 3S diluted 5000 times to prepare a drug solution B containing compound B at twice the concentrations recorded in Tables 1 to 4.

[0419] {The formulation containing compound B used in the test examples}

[0420] Test No. a: Pyridaben: Piranika EW (manufactured by Nippon Soda Co., Ltd.)

[0421] Test numbers b and h: Thiamethoxam: Nissorun wettable powder (manufactured by Nippon Soda Co., Ltd.)

[0422] Test number c: Azoxystrobin: Danitoron flowable formulation (manufactured by Nippon Nippon Kogyo Co., Ltd.)

[0423] Test No. d: Omite wettable powder (manufactured by Nippon Nippon Agricultural Products Co., Ltd.)

[0424] Test No. e: Azoxystrobin: Hachi-Hachi flowable formulation (manufactured by OAT Agrio)

[0425] Test number f: Avermectin: Agrimek (manufactured by Syngenta Japan)

[0426] Test number g: Etoxazole: Baroque flowable formulation (manufactured by Kyoyu Agri)

[0427] Test No. i: Sulfadiazine: Rabin Wettable Powder 75 (manufactured by Bayer Global Science)

[0428] Test No. J: Spinosin: Water-dispersible granules (manufactured by Kumiai Chemical Co., Ltd.)

[0429] Experiment number k: Different Azoxystrobin: Karuhos emulsion (manufactured by Nippon Soda Co., Ltd.)

[0430] Test No. 1: Acetamiprid: Mospiran water-soluble powder (manufactured by Nippon Soda Co., Ltd.)

[0431] Test number m: Fipronil: Prince flowable formulation (manufactured by BASF)

[0432] Test No. n: Tetrabromopyrethroid: Scout flowable formulation (manufactured by Nippon Soda Co., Ltd.)

[0433] Test No. o: BT agent (live spores of Bacillus thuringiensis and the crystalline toxins produced): Zentari water-dispersible granules (manufactured by Beixing Chemical Industry Co., Ltd.)

[0434] Test number p: Thiamethoxam: Applaud flowable formulation (manufactured by Nippon Nippon Agricultural Products Co., Ltd.)

[0435] Test number q: Flyicide: Trigard liquid (manufactured by Syngenta Japan Co., Ltd.)

[0436] Test No. r: Tebufenozide: Romdan flowable formulation (manufactured by Nippon Soda Co., Ltd.)

[0437] Test No. s: Flufenoxuron: Phoenix water-dispersible granules (manufactured by Nippon Nippon Agricultural Products Co., Ltd.) Test No. t: Acetaminophen: PLEO flowable formulation (manufactured by Kyoyu Agri Co., Ltd.)

[0438] Test number u: Lufenuron: Machi emulsion (manufactured by Syngenta Japan)

[0439] Test No. v: Flupyradifurone: Urara DF (manufactured by ISK Bio Sciences)

[0440] Test number w: Bromnitrothion: Kotetsu flowable formulation (manufactured by Nippon Nippon Agricultural Products Co., Ltd.)

[0441] Test No. x: Indoxacarb: Tornado flowable formulation (manufactured by Kumiai Chemical Co., Ltd.) Test No. y: Diethylurea: Gamba wettable powder (manufactured by Syngenta Japan Co., Ltd.)

[0442] Test number z: Insecticidal ring: Evisect wettable powder (manufactured by MITSUI CHEMICALS AGRO)

[0443] Test No. aa: Emamectin benzoate: Affirm emulsion (manufactured by Syngenta Japan)

[0444] Test No. ab: Pyridaben: Sunmite wettable powder (manufactured by Nissan Chemical Co., Ltd.)

[0445] The mixture obtained by mixing equal amounts of drug solution A and drug solution B using a rotating dispersion tower is dispersed at a density of 1 cm. 2 Distribute 2 mg of the solution into petri dishes containing two-spotted spider mites on bean leaves (AB mixed zone).

[0446] Drug solution A and drug solution B were diluted to 2 times with water containing Rabiden 3S diluted 5000 times, respectively, to obtain drug solution A' and drug solution B'.

[0447] The drug solution A' was dispersed at 1 cm using a rotating dispersing tower. 2Distribute 2 mg of the solution into another petri dish (A single-use zone) containing bean leaves inoculated with two-spotted spider mites. Additionally, use a rotary dispersing tower to distribute solution B' at 1 cm⁻¹. 2 Distribute 2 mg of the solution into another petri dish (B single-use zone) containing two-spotted spider mites on a bean leaf.

[0448] Then, the petri dishes containing the drug solution were placed in a constant temperature room at 25°C and 60% humidity. The mortality rate of the adults was investigated 3 days after the drug was introduced, and the corrected adult killing rate was calculated.

[0449] Corrected adult kill rate (%) = (Ta-Ca) / (100-Ca)×100

[0450] Ca: Adult insect kill rate in the untreated area 3 days later

[0451] Ta: Adult insect kill rate in the treated area 3 days later

[0452] After assessing the survival of the adults, all adults were removed. The culture dishes, now free of adults, were then placed in a constant-temperature room at 25°C and 60% humidity. Ten days after dispersal, the number of surviving offspring was assessed, and the survival rate was calculated.

[0453] Efficiency (%) = (Cn - Tn) / Cn × 100

[0454] Cn: Number of next-generation survivors after 10 days in the untreated area.

[0455] Tn: Number of next-generation survivors in the processing area after 10 days.

[0456] To demonstrate the degree of synergistic effect, the "expected value of corrected adult insect killing rate" and "expected value of effectiveness" were calculated based on the Colby method. A synergistic effect was judged to exist when the corrected adult insect killing rate or effectiveness was greater than the "expected value of corrected adult insect killing rate" and "expected value of effectiveness," respectively.

[0457] The expected value (E) of the corrected adult killing rate (%) or effectiveness (%) is: X + Y - XY / 100

[0458] X: Measured corrected adult killing rate (%) or effectiveness (%) in zone B.

[0459] Y: Measured corrected adult killing rate (%) or effectiveness (%) in the single-use zone of A.

[0460] [Table 1]

[0461]

[0462] [Table 2]

[0463]

[0464] [Table 3]

[0465]

[0466] [Table 4]

[0467]

[0468] As demonstrated in the experimental examples, a synergistic effect was observed when compound A and compound B were applied together to the target organism. The pest control method and pest control composition of the present invention can control pests such as insects and mites more safely with less dosage.

Claims

1. A pest control composition comprising 3-oper-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridinoxy]-9-azabicyclo[3.3.1]nonane and an insecticidal or acaricidal active ingredient, The insecticidal or acaricidal active ingredients are pyridaben, thiamethoxam, clodinafop-methyl, acetamiprid, abamectin, etoxazole, thiamethoxam, spinosad, and isopropoxide. Azoxystrobin, acetamiprid, fipronil, tetrabromopyr, BT agent, cyromazine, tebufenozide, flufenoxuron, acetamiprid, lufenuron, flonicamid, bromfenoxuron, indoxacarb, emamectin benzoate or pyridaben, The mass ratio of 3-endo-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridoxy]-9-azabicyclo[3.3.1]nonane to the insecticidal or acaricidal active ingredient, i.e., 3-endo-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridoxy]-9-azabicyclo[3.3.1]nonane / insectic or acaricidal active ingredient is 200 / 1 to 1 / 200. The harmful organism is a mite.

2. The pest control composition according to claim 1, wherein, The insecticidal or acaricidal active ingredients are thiamethoxam or etoxazole.

3. A method for controlling pests, comprising applying the pest control agent composition of claim 1 or 2 to mites.

4. The method for controlling pests according to claim 3, wherein, The mites in question are from the genus Tetranychus.

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