Ablation electrode needle and needle tract ablation device for irreversible electroporation ablation

Abstract

The present disclosure provides an ablation electrode needle and a needle tract ablation device for irreversible electroporation ablation, the ablation electrode needle comprising: a needle tube body, the needle tube body being a hollow tube; a wiring terminal, the wiring terminal being arranged on the needle tube body, comprising a first wiring terminal and a second wiring terminal, the first wiring terminal and the second wiring terminal being respectively connected to the positive and negative poles of a predetermined DC power supply, so that a heating area is formed between the first wiring terminal and the second wiring terminal; a temperature sensor, being arranged between the first wiring terminal and the second wiring terminal in the needle tube body, for detecting the temperature of the heating area. The ablation electrode needle of the present disclosure is a single-needle self-heating method, which does not require an additional electrode to form an output circuit, thus simplifying the surgical method; the needle tract ablation device solves the problem that needle tract ablation cannot be performed in irreversible electroporation ablation, thereby reducing bleeding and implantation.

Description

Technical Field

[0001] The present disclosure relates to the field of electroporation ablation, and in particular to an ablation electrode needle and a needle tract ablation device for irreversible electroporation ablation. Background Art

[0002] Irreversible electroporation ablation is a new ablation method in the field of tumor ablation. Irreversible electroporation ablation uses high-voltage narrow pulses to act on the lesion site, causing nanoscale permanent perforation of the cell membrane, thereby leading to tumor cell apoptosis.

[0003] In minimally invasive ablation surgery, when ablation is completed, needle tract ablation is usually required to prevent needle tract bleeding when the needle is withdrawn, and to reduce the risk of virus implantation in the needle tract area when the ablation electrode needle is pulled out of the lesion and out of the human body. Current electroporation ablation devices do not have a dedicated needle tract ablation function, and there is a risk of bleeding and implantation during surgery. Therefore, there is an urgent need for an ablation electrode needle and needle tract ablation device for irreversible electroporation ablation. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] The present disclosure provides an ablation electrode needle and a needle tract ablation device for irreversible electroporation ablation, so as to at least partially solve the technical problems mentioned above.

[0006] (II) Technical solution

[0007] According to one aspect of the present disclosure, an ablation electrode needle for irreversible electroporation ablation is provided, comprising:

[0008] A needle tube body, wherein the needle tube body is in a hollow tubular shape;

[0009] A wiring terminal, which is disposed on the needle body and includes a first wiring terminal and a second wiring terminal, wherein the first wiring terminal and the second wiring terminal are respectively connected to the positive and negative electrodes of a predetermined DC power supply, so that a heating area is formed between the first wiring terminal and the second wiring terminal; and

[0010] The temperature sensor is arranged between the first terminal and the second terminal in the needle body and is used to detect the temperature of the heating area.

[0011] According to an embodiment of the present disclosure, the first terminal is located at the needle tip of the needle tube body, and the distance between the first terminal and the second terminal is not less than the length of the maximum exposed area of ​​the electrode needle.

[0012] According to an embodiment of the present disclosure, the temperature sensor is disposed at a midpoint between the first terminal and the second terminal in the needle tube body.

[0013] According to an embodiment of the present disclosure, the temperature sensor is a thermocouple.

[0014] According to an embodiment of the present disclosure, the ablation electrode needle further includes:

[0015] An electrode needle connector, wherein the electrode needle connector is electrically connected to the first wiring terminal, the second wiring terminal and the temperature sensor, and is used to realize electrical connection between the first wiring terminal, the second wiring terminal and the temperature sensor and the outside world.

[0016] According to another aspect of the present disclosure, there is provided a needle tract ablation device for irreversible electroporation ablation, comprising:

[0017] Ablation electrode needle as described above;

[0018] A temperature acquisition module, used to acquire the temperature signal detected by the temperature sensor;

[0019] a constant current module, used for applying a constant current between the first wiring terminal and the second wiring terminal; and

[0020] The controller module is connected to the temperature acquisition module and the constant current module, and is used to control the output of the constant current module according to the temperature data acquired by the temperature acquisition module, so that the temperature of the heating area is maintained at a constant value.

[0021] According to an embodiment of the present disclosure, the temperature acquisition module includes: a filter circuit submodule, an amplification circuit submodule and an analog-to-digital conversion submodule.

[0022] According to an embodiment of the present disclosure, the supply voltage of the constant current module is 5 to 9V, and the output current is 3 to 5A.

[0023] According to an embodiment of the present disclosure, the temperature acquisition module is connected to the temperature sensor of the ablation electrode needle through the electrical connector; the constant current module is connected to the first terminal and the second terminal of the ablation electrode needle through the electrical connector.

[0024] According to another aspect of the present disclosure, a device for irreversible electroporation ablation is provided, characterized in that it includes the ablation electrode needle as described above or the needle tract ablation device as described above.

[0025] (III) Beneficial effects

[0026] It can be seen from the above technical solutions that the ablation electrode needle and needle tract ablation device for irreversible electroporation ablation disclosed in the present invention have at least one of the following beneficial effects:

[0027] (1) The ablation electrode needle disclosed in the present invention is a single-needle self-heating method, and no additional electrodes are required to form an output circuit, which simplifies the surgical method;

[0028] (2) The needle tract ablation device disclosed in the present invention solves the problem that irreversible electroporation ablation cannot perform needle tract ablation, thereby reducing bleeding and implantation;

[0029] (3) The needle tract ablation device disclosed in the present invention is powered by a low-voltage power supply, thereby improving safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a schematic diagram of the structure of an ablation electrode needle used for irreversible electroporation ablation according to an embodiment of the present disclosure.

[0031] Figure 2 It is a schematic diagram of the structure of a needle tract ablation device for irreversible electroporation ablation according to an embodiment of the present disclosure.

[0032] Figure 3 Schematic diagram of the structure of the constant current module according to the embodiment of the present disclosure. DETAILED DESCRIPTION

[0033] The present disclosure provides an ablation electrode needle and a needle tract ablation device for irreversible electroporation ablation, the ablation electrode needle comprising: a needle tube body, the needle tube body being a hollow tube; a wiring terminal, the wiring terminal being arranged in the needle tube body, comprising a first wiring terminal and a second wiring terminal, the first wiring terminal and the second wiring terminal being respectively connected to the positive and negative poles of a predetermined DC power supply, so that a heating area is formed between the first wiring terminal and the second wiring terminal; a temperature sensor, arranged between the first wiring terminal and the second wiring terminal in the needle tube body, for detecting the temperature of the heating area. The needle tract ablation device comprises a temperature acquisition module, a controller module, a constant current module and the above-mentioned ablation electrode needle.

[0034] In order to make the objectives, technical solutions and advantages of the present disclosure more clearly understood, the present disclosure is further described in detail below in combination with specific embodiments and with reference to the accompanying drawings.

[0035] Certain embodiments of the present disclosure will be described more fully below with reference to the accompanying drawings, some but not all of which will be shown. In fact, the various embodiments of the present disclosure may be implemented in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that the present disclosure satisfies applicable legal requirements.

[0036] In an exemplary embodiment of the present disclosure, an ablation electrode needle for irreversible electroporation ablation is provided.

[0037] Figure 1 FIG. 1 is a schematic diagram of the structure of an ablation electrode needle used for irreversible electroporation ablation according to an embodiment of the present disclosure. Figure 1As shown, the ablation electrode needle 100 for irreversible electroporation ablation disclosed in the present invention includes: a needle tube body 101 , a connection terminal 102 and a temperature sensor 103 .

[0038] The following is a detailed description of the various parts of the ablation electrode needle used for irreversible electroporation ablation in this embodiment.

[0039] The needle tube body 101 is a hollow tube. The needle tube body 101 of the irreversible electroporation ablation electrode needle is generally made of metal and has conductive properties.

[0040] The wiring terminal 102 is arranged in the needle tube body 101, and includes a first wiring terminal 1021 and a second wiring terminal 1022. The first wiring terminal 1021 and the second wiring terminal 1022 are respectively connected to the positive and negative poles of a predetermined DC power supply, so that a heating area is formed between the first wiring terminal 1021 and the second wiring terminal 1022.

[0041] Specifically, in the embodiment of the present disclosure, a DC voltage with a constant current output is applied to both ends of a needle tube body 101. When a large current passes through the internal resistance of the needle tube, the needle tube self-heats, causing the surface temperature of the needle tube to rise rapidly, thereby achieving the purpose of needle tract ablation.

[0042] Please see again Figure 1 In order to realize the ablation electrode needle 100 disclosed in the present invention, a first terminal 1021 and a second terminal 1022 can be respectively set near the needle tip of the needle tube body 101 and on the inner wall of the needle tube at a distance from the needle tip, and leads are welded as the positive and negative poles of the DC voltage (there is no need to distinguish between the positive and negative poles), and the area between the leads is the heating area.

[0043] The ablation temperature needs to be controlled during needle tract ablation, so a temperature sensor 103 is required to measure the temperature of the needle body 101. The temperature sensor 103 is disposed between the first terminal 1021 and the second terminal 1022 on the inner wall of the needle body 101 to detect the temperature of the heating area.

[0044] The ablation electrode needle also includes an electrode needle connector (not shown), which is electrically connected to the first terminal 1021, the second terminal 1024 and the temperature sensor 103, and is used to realize electrical connection between the first terminal 1021, the second terminal 1022 and the temperature sensor 103 and the outside world.

[0045] Specifically, in this embodiment, a thermocouple is used as the temperature sensor 103. Figure 1As shown, the thermocouple can be welded to the middle part of the heating area. Point A is the setting position of the first terminal 1021, which is located near the needle tip, and point B is the setting position of the second terminal 1022, which is 4 cm away from point A, to ensure that the distance between AB is not less than the maximum exposure area length of the electrode needle. Point C is the position for welding the thermocouple, which is the midpoint between AB. The V+ connecting wire, the V- connecting wire and the thermocouple connecting wire are connected to the electrode needle connector inside the needle tube, and are connected to the needle tract ablation device through the connector.

[0046] The ablation electrode needle of the disclosed embodiment is a single-needle self-heating method, and does not require additional electrodes to form an output circuit, thereby simplifying the surgical method.

[0047] In yet another exemplary embodiment of the present disclosure, a needle tract ablation device for irreversible electroporation ablation is provided.

[0048] Figure 2 FIG. 1 is a schematic diagram of the structure of a needle tract ablation device for irreversible electroporation ablation according to an embodiment of the present disclosure. Figure 2 As shown, the needle tract ablation device for irreversible electroporation ablation disclosed in the present invention includes an ablation electrode needle 100 , a temperature acquisition module 200 , a constant current module 300 and a controller module 400 .

[0049] The ablation electrode needle 100 is the ablation electrode needle as described in the previous embodiment.

[0050] The temperature acquisition module 200 is used to acquire the temperature signal detected by the temperature sensor. Specifically, in this embodiment, the temperature sensor is a thermocouple, so the temperature acquisition module can use a dedicated thermocouple acquisition chip.

[0051] In the disclosed embodiment, the temperature acquisition module 200 includes: a filter circuit submodule, an amplifier circuit submodule and an analog-to-digital conversion submodule. The temperature acquisition module 200 can be connected to the temperature sensor of the ablation electrode needle through the electrical connector. The temperature acquisition module 200 acquires the thermocouple signal, performs filtering and amplification, and converts the analog quantity into a digital quantity to the controller module 400.

[0052] The constant current module 300 is used to apply a constant current between the first wiring terminal and the second wiring terminal. The constant current module 300 is connected 1022 to the first wiring terminal 1021 and the second wiring terminal of the ablation electrode needle through the electrical connector.

[0053] Figure 3 Schematic diagram of the structure of the constant current module of the present disclosure embodiment. Figure 3As shown, the constant current module 300 includes an operational amplifier connected to form negative feedback. The constant current module 300 is powered by 5V, the needle tube body 101 is connected between the V+ connection line and the V- connection line, and the internal resistance of the needle tube body 101 is used as a load. The on-resistance of the MOS tube Q is adjusted through the negative feedback characteristics of the operational amplifier to achieve constant current. In addition, the controller module 400 can also stop the constant current output by saturating Q1 through the RST signal.

[0054] In this embodiment, the constant current value I=Vref / R, where Vref is the reference voltage connected to the positive pole of the operational amplifier, and R is the resistance connected between the negative pole of the operational amplifier and the ground. Since the internal resistance of the needle tube body 101 in the heating area is small (generally less than 0.5 ohms), a large current needs to be provided to quickly generate heat, so 5A current is a feasible setting value. In one embodiment, R can be selected as 0.5 ohms, and the reference voltage Vref is 2.5V.

[0055] The controller module 400 is connected to the temperature acquisition module 200 and the constant current module 300, and is used to control the output of the constant current module 300 according to the temperature data acquired by the temperature acquisition module 200, so that the temperature of the heating area is kept at a constant value.

[0056] The needle tract ablation device disclosed in the present invention solves the problem that irreversible electroporation ablation cannot perform needle tract ablation, thereby reducing bleeding and implantation; at the same time, the needle tract ablation device disclosed in the present invention is powered by a low-voltage power supply, thereby improving safety.

[0057] In yet another embodiment of the present disclosure, a device for irreversible electroporation ablation is provided, comprising the ablation electrode needle as described in the previous embodiment or the needle tract ablation device as described in the previous embodiment.

[0058] So far, the embodiments of the present disclosure have been described in detail in conjunction with the accompanying drawings. It should be noted that the implementation methods not shown or described in the drawings or the body of the specification are all forms known to ordinary technicians in the relevant technical field and are not described in detail. In addition, the above definitions of each element and method are not limited to the various specific structures, shapes or methods mentioned in the embodiments, and ordinary technicians in the field can simply change or replace them.

[0059] Unless otherwise indicated, the numerical parameters in this specification and the appended claims are approximate values ​​and can vary according to the desired properties obtained through the content of the present disclosure. Specifically, all numbers used in the specification and claims to express the content of the composition, reaction conditions, etc., should be understood to be modified by the term "about" in all cases. In general, the meaning of the expression is to include a variation of ±10% in some embodiments, ±5% in some embodiments, ±1% in some embodiments, and ±0.5% in some embodiments by a specific number.

[0060] Furthermore, the word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements.

[0061] The ordinal numbers used in the specification and claims, such as "first", "second", "third", etc., to modify the corresponding elements, do not themselves mean that the elements have any ordinal numbers, nor do they represent the order of one element and another element, or the order in the manufacturing method. The use of these ordinal numbers is only used to clearly distinguish a component with a certain name from another component with the same name.

[0062] In addition, unless the steps are specifically described or must occur in sequence, the order of the above steps is not limited to the above list, and can be changed or rearranged according to the required design. And the above embodiments can be mixed and matched with each other or with other embodiments based on design and reliability considerations, that is, the technical features in different embodiments can be freely combined to form more embodiments.

[0063] The algorithms and displays provided herein are not inherently related to any particular computer, virtual system or other device. Various general purpose systems may also be used together with the teachings based thereon. According to the above description, it is apparent that the structure required for constructing such systems is. In addition, the present disclosure is not directed to any particular programming language either. It should be understood that various programming languages ​​may be utilized to implement the disclosure described herein, and the description of the specific languages ​​above is intended to disclose the best mode of implementation of the present disclosure.

[0064] The present disclosure can be implemented by means of hardware including several different elements and by means of a suitably programmed computer. The various component embodiments of the present disclosure can be implemented in hardware, or in software modules running on one or more processors, or in a combination thereof. It should be understood by those skilled in the art that a microprocessor or digital signal processor (DSP) can be used in practice to implement some or all functions of some or all components in the related equipment according to the embodiments of the present disclosure. The present disclosure can also be implemented as a device or apparatus program (e.g., computer program and computer program product) for executing part or all of the methods described herein. Such a program implementing the present disclosure can be stored on a computer-readable medium, or can have the form of one or more signals. Such a signal can be downloaded from an Internet website, or provided on a carrier signal, or provided in any other form.

[0065] Those skilled in the art will appreciate that the modules in the devices in the embodiments may be adaptively changed and set in one or more devices different from the embodiments. The modules or units or components in the embodiments may be combined into one module or unit or component, and in addition they may be divided into multiple submodules or subunits or subcomponents. All features disclosed in this specification (including the accompanying claims, abstracts and drawings) and all processes or units of any method or device disclosed in this manner may be combined in any combination, except that at least some of such features and / or processes or units are mutually exclusive. Unless otherwise expressly stated, each feature disclosed in this specification (including the accompanying claims, abstracts and drawings) may be replaced by an alternative feature that provides the same, equivalent or similar purpose. Furthermore, in a unit claim that lists several devices, several of these devices may be embodied by the same hardware item.

[0066] Similarly, it should be understood that in order to streamline the present disclosure and aid in understanding one or more of the various disclosed aspects, in the above description of the exemplary embodiments of the present disclosure, the various features of the present disclosure are sometimes grouped together into a single embodiment, figure, or description thereof. However, this disclosed method should not be interpreted as reflecting the following intention: the claimed disclosure requires more features than the features explicitly recited in each claim. More specifically, as reflected in the claims below, the disclosed aspects are less than all the features of the single embodiment disclosed above. Therefore, the claims that follow the specific embodiment are hereby expressly incorporated into the specific embodiment, with each claim itself serving as a separate embodiment of the present disclosure.

[0067] The specific embodiments described above further illustrate the purpose, technical solutions and beneficial effects of the present disclosure. It should be understood that the above description is only a specific embodiment of the present disclosure and is not intended to limit the present disclosure. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present disclosure should be included in the protection scope of the present disclosure.

Claims

1. An ablation electrode needle for irreversible electroporation ablation, characterized in that: include: A needle tube body, wherein the needle tube body is in a hollow tubular shape; A wiring terminal, the wiring terminal is arranged in the needle body, and includes a first wiring terminal and a second wiring terminal, the first wiring terminal and the second wiring terminal are respectively connected to the positive and negative electrodes of a predetermined DC power supply, so that a heating area is formed between the first wiring terminal and the second wiring terminal; and A temperature sensor is disposed between the first terminal and the second terminal in the needle body and is used to detect the temperature of the heating area; Among them, the first terminal is located at the needle tip of the needle tube body, and the distance between the first terminal and the second terminal is not less than the length of the maximum exposed area of ​​the electrode needle; the temperature sensor is arranged at the midpoint between the first terminal and the second terminal.

2. The ablation electrode needle according to claim 1, characterized in that: The temperature sensor is a thermocouple.

3. The ablation electrode needle according to claim 1, characterized in that: Also includes: An electrode needle connector, wherein the electrode needle connector is electrically connected to the first wiring terminal, the second wiring terminal and the temperature sensor, and is used to realize electrical connection between the first wiring terminal, the second wiring terminal and the temperature sensor and the outside world.

4. A needle tract ablation device for irreversible electroporation ablation, characterized in that: include: The ablation electrode needle according to any one of claims 1 to 3; A temperature acquisition module, used to acquire the temperature signal detected by the temperature sensor; A constant current module, used for applying a constant current between the first wiring terminal and the second wiring terminal; as well as The controller module is connected to the temperature acquisition module and the constant current module, and is used to control the output of the constant current module according to the temperature data acquired by the temperature acquisition module, so that the temperature of the heating area is maintained at a constant value.

5. The needle tract ablation device according to claim 4, characterized in that: The temperature acquisition module includes: a filter circuit submodule, an amplifier circuit submodule and an analog-to-digital conversion submodule.

6. The needle tract ablation device according to claim 4, characterized in that: The supply voltage of the constant current module is 5~9V, and the output current is 3~5A.

7. The needle tract ablation device according to claim 4, characterized in that: The temperature acquisition module is connected to the temperature sensor of the ablation electrode needle through an electrical connector; the constant current module is connected to the first wiring terminal and the second wiring terminal of the ablation electrode needle through an electrical connector.

8. A device for irreversible electroporation ablation, characterized in that: It comprises the ablation electrode needle as described in any one of claims 1 to 3 or the needle tract ablation device as described in any one of claims 4 to 7.

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