Device for modeling Achilles tendon strain induced by passive exercise in rats

Abstract

The present application discloses a rat passive movement-induced Achilles tendon strain modeling device, comprising a bracket, a rat fixing device arranged on the top of the bracket and a driving component arranged inside the bracket, wherein a through hole is arranged on the rear side of the rat fixing device at the top of the bracket, the driving component comprises driven gears arranged on the left and right sides of the bracket and a driving device driving the driven gears to rotate, and a hind limb fixing device rotatably connected to the driven gears is eccentrically arranged on the opposite surfaces of the two driven gears; when in use, the abdomen of the rat is fixed on the rat fixing device, the hind limbs enter the inside of the bracket through the through hole, the hind limbs are fixed on the hind limb fixing device, the driving device is started, the driven gears rotate, and the hind limbs fixed on the driven gears form a passive running posture, so that the exercise time and the hind limb exercise posture can be adjusted according to the preset overload standard, the Achilles tendon of the rat is overloaded and stretched in a short time, and finally an Achilles tendon strain model with extremely high biosimilarity is quickly and efficiently obtained.

Description

Technical Field

[0001] The invention relates to the technical field of rat Achilles tendon strain modeling, in particular to a rat passive movement-induced Achilles tendon strain modeling device. Background Art

[0002] Clinically, overload exercise-induced Achilles tendon injuries account for the vast majority of sports injuries. Therefore, it is particularly important to study the pathogenesis of overload exercise-induced Achilles tendon strain. In order to study its pathogenesis, it is extremely critical to construct an animal model of overload exercise-induced Achilles tendon strain with high biosimilarity, feasibility, reliability and repeatability. At present, the commonly used animal model of Achilles tendon strain is the rat active overload running model, in which rats are actively overloaded on a treadmill to induce Achilles tendon strain.

[0003] However, this model is time-consuming and has low feasibility. First, because rats are light in weight, the load borne by their hind limbs during active running is small. Second, because rats are actively running, there is a fatigue time limit. When they feel tired, they will stop running on their own initiative, thus failing to achieve the preset overload running standard, let alone induce Achilles tendon strain.

[0004] Therefore, how to solve the problems existing in the existing rat active overload running model has become a technical problem that technicians in this field urgently need to solve. Summary of the invention

[0005] The purpose of the present invention is to provide a rat passive exercise-induced Achilles tendon strain modeling device to solve the problem in the prior art that when using a rat active overload running model, the rat's light weight leads to a small load on the hind limbs, and the rat will actively stop running when it feels tired, so the preset overload running standard cannot be reached and Achilles tendon strain cannot be induced.

[0006] The various technical effects that can be produced by the preferred technical solutions among the various technical solutions provided by the present invention are described in detail below.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] The present invention provides a rat passive movement-induced Achilles tendon strain modeling device, comprising a hollow bracket, a rat fixing device arranged on the top of the bracket, and a driving component arranged inside the bracket for driving the rat's hind limbs to move, wherein:

[0009] A through hole is provided at the top of the bracket at the rear side of the rat fixing device for the rat hind limbs to pass through the inside of the bracket;

[0010] The driving assembly includes driven gears arranged on the left and right sides of the bracket and a driving device for driving the driven gears to rotate. The rotation axis of the driven gears is along the left and right direction of the bracket. A hind limb fixing device is eccentrically arranged on the opposite surfaces of the two driven gears. The hind limb fixing device is rotationally connected to the driven gears, and the rotation direction is along the left and right direction of the bracket.

[0011] Preferably, a heating plate is provided on the top of the support below the rat fixing device.

[0012] Preferably, the driving assembly is connected to the bracket via a moving assembly, the moving assembly includes a first moving frame sliding along the front-to-back direction of the bracket and a second moving frame sliding along the up-and-down direction of the first moving frame, and the driving device and the driven gear are both connected to the second moving frame.

[0013] Preferably, the rat fixing device comprises two detachably connected semi-cylindrical cylinders, which are buckled together to form a cylinder whose axis extends along the front-to-back direction of the bracket, and the bottoms of the two semi-cylindrical cylinders are detachably connected to the bracket.

[0014] Preferably, a hook extending downward is provided at the bottom of the semi-cylindrical tube, and a slot is provided at a position corresponding to the hook on the bracket, the hook and the slot are both L-shaped, and the width of the slot along the left and right direction is greater than the thickness of the hook along the left and right direction.

[0015] Preferably, the driving device comprises a motor and a reduction gear arranged between the motor and the driven gear.

[0016] Preferably, the hind limb fixing device is a columnar structure, and a hollow cylinder for the rat's hind limbs to penetrate is arranged along the axis of the columnar structure.

[0017] Preferably, hooks are provided on the left and right sides of the top of the bracket.

[0018] Preferably, two through holes are provided, respectively disposed on the left and right sides of the rear side of the rat fixing device.

[0019] Preferably, a locking device is provided between the second movable frame and the first movable frame.

[0020] The invention provides a rat passive exercise-induced Achilles tendon strain modeling device, which has the following beneficial effects:

[0021] The invention provides a rat passive movement-induced Achilles tendon strain modeling device, comprising a hollow bracket, a rat fixing device arranged on the top of the bracket, and a driving component arranged inside the bracket for driving the rat's hind limbs to move, wherein a through hole for the rat's hind limbs to penetrate into the bracket is arranged at the top of the bracket at a position located on the rear side of the rat fixing device, and the driving component comprises a driven gear arranged on the left and right sides of the bracket and a driving device for driving the driven gear to rotate, wherein the rotation axis of the driven gear is along the left and right directions of the bracket, and a hind limb fixing device is eccentrically arranged on the opposite surface of the driven gear, and the hind limb fixing device is rotationally connected with the driven gear, and the rotation direction along the left and right directions of the bracket; when the rat stops actively running due to fatigue, the rat can be anesthetized, and in its anesthetized state, the abdomen of the rat is fixed on the rat fixing device, the hind limbs enter the inside of the bracket through the through hole, and then the hind limbs are fixed on the hind limb fixing device. At this time, the driving device is started, and the driving device drives the driven gear to rotate, so that the hind limbs fixed on the driven gear also move together to form a passive running state, so that the exercise time and the hind limb exercise posture can be adjusted according to the preset overload standard, so that the Achilles tendon of the rat can be overloaded and stretched in a short time, and finally an Achilles tendon strain model with extremely high biosimilarity is obtained quickly and efficiently.

[0022] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 1 is a front view of a rat passive exercise-induced Achilles tendon strain modeling device shown in an embodiment of the present invention;

[0025] Figure 2 1 is a left view of a rat passive exercise-induced Achilles tendon strain modeling device shown in an embodiment of the present invention;

[0026] Figure 3 The embodiment of the present invention is shown Figure 2 The enlarged view of point A in the middle;

[0027] Figure 4 1 is a top view of a rat passive exercise-induced Achilles tendon strain modeling device shown in an embodiment of the present invention.

[0028] In the figure: 1, through hole; 2, driven gear; 3, hind limb fixing device; 4, heating plate; 5, first mobile frame; 6, second mobile frame; 7, semi-cylindrical tube; 8, hook; 9, slot; 10, motor; 11, reduction gear; 12, hook; 13, locking bolt; 14, buckle; 15, top plate; 16, bottom plate; 17, vertical pole. DETAILED DESCRIPTION

[0029] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0030] The following is an explanation of the embodiments with reference to the accompanying drawings. In addition, the embodiments shown below do not limit the invention described in the claims. In addition, the entire contents of the configurations shown in the following embodiments are not limited to the solutions required as the invention described in the claims.

[0031] See also Figure 1 , Figure 1 It is a front view of a rat passive exercise-induced Achilles tendon strain modeling device shown in an embodiment of the present invention. In this application, the directions are defined as follows: the direction perpendicular to the inside of the paper is the front, the direction perpendicular to the inside of the paper is the back, and the left and right directions parallel to the paper are the left and right directions in the text.

[0032] See also Figure 1 to Figure 4The present invention provides a rat passive movement-induced Achilles tendon strain modeling device, comprising a hollow bracket, a rat fixing device arranged on the top of the bracket, and a driving component arranged inside the bracket for driving the rat's hind limbs to move. A through hole 1 for the rat's hind limbs to penetrate into the bracket is arranged at the top of the bracket at the rear side of the rat fixing device, and the driving component comprises a driven gear 2 arranged on the left and right sides of the bracket and a driving device for driving the driven gear 2 to rotate. The rotation axis of the driven gear 2 is along the left and right directions of the bracket, and a hind limb fixing device 3 is eccentrically arranged on the opposite surface of the driven gear 2. The hind limb fixing device 3 is rotationally connected with the driven gear 2, and the rotation The direction is along the left and right direction of the bracket; when the rat stops actively running due to fatigue, the rat can be anesthetized. In its anesthetized state, the abdomen of the rat is fixed on the rat fixing device, and the hind limbs enter the inside of the bracket through the through hole 1, and then the hind limbs are fixed on the hind limb fixing device 3. At this time, the driving device is started, and the driving device drives the driven gear 2 to rotate, so that the hind limbs fixed on the driven gear 2 also move together to form a passive running state, so that the exercise time and the hind limb exercise posture can be adjusted according to the preset overload standard, so that the Achilles tendon of the rat can be overloaded and stretched in a short time, and finally an Achilles tendon strain model with extremely high biosimilarity is obtained quickly and efficiently.

[0033] Furthermore, the hind limb fixing device 3 can be a small hollow cylinder, which can be connected to the driven gear 2 through a rotating shaft and a bearing, and the rat's hind limbs are fixed in the hollow part of the small cylinder.

[0034] In practice, the above-mentioned bracket may include a top plate 15, a bottom plate 16 and a vertical rod 17 arranged between the top plate 15 and the bottom plate 16. The top plate 15 and the bottom plate 16 may be rectangular steel plates, and the vertical rod 17 is arranged at the four corners of the rectangular steel plates to form a hollow rectangular frame.

[0035] Preferably, the rat fixing device can be arranged in the middle position of the top of the bracket, i.e., the middle position of the top plate 15, and a heating plate 4 can be arranged at the bottom center of the top plate 15, i.e., the bottom of the rat fixing device, so that the rat can still maintain body temperature under anesthesia.

[0036] Optionally, in order to adapt the modeling device to rats of different sizes, the above-mentioned driving component can be connected to the bracket through a moving component, and the moving component can include a first moving frame 5 sliding along the front and rear direction of the bracket and a second moving frame 6 sliding along the up and down direction of the first moving device. The driving device and the driven gear 2 are both connected to the second moving frame 6. When in use, the passive movement posture of the rat can be personalized by adjusting the front and rear position of the first moving frame 5 and the height of the second moving frame 6 according to the length of the rat's hind limbs.

[0037] Specifically, the first movable frame 5 mentioned above can be a movable rod, and two movable rods are provided, which are respectively located on both sides of the rat fixing device, and pulleys are provided on the top and bottom of the movable rod. Slide grooves are provided at the positions of the top plate 15 and the bottom plate 16 corresponding to the movable rod, and the slide grooves extend along the front and rear directions of the bracket. The second movable frame 6 can be an L-shaped plate structure, including a vertical plate and a horizontal plate. The horizontal plate extends horizontally toward the inner direction of the bracket. A sliding hole that longitudinally penetrates the vertical plate can be provided on the vertical plate, and is slidably connected to the movable rod through the sliding hole. The driven gear 2 is connected to the vertical plate through a rotating shaft, and the rotating shaft is perpendicular to the vertical plate. One end of the rotating shaft is connected to the vertical plate, and the other end extends to the bottom of the through hole 1 and is connected to the driven gear 2. The driving device is provided on the horizontal plate and is transmission-connected to the driven gear 2 to drive the driven gear 2 to rotate, or the first movable frame 5 mentioned above can be a long strip plate structure, and at least two pulleys are installed on the top and bottom of the plate structure along the front and rear directions.

[0038] The rat fixing device may include two detachably connected semi-cylindrical tubes 7, which are buckled to form a cylinder with an axis extending along the front-back direction of the bracket, and the bottoms of the two semi-cylindrical tubes 7 are detachably connected to the bracket.

[0039] Specifically, when the above-mentioned semi-cylindrical tube 7 is connected to the bracket, the opening of the semi-cylindrical tube 7 can be respectively facing the left and right sides, and a downwardly extending hook 8 is provided at the bottom of the semi-cylindrical tube 7, and a slot 9 is provided at a position corresponding to the hook 8 on the bracket. The hook 8 and the slot 9 can both be L-shaped, and the hook 8 includes a vertical portion and a horizontal portion, and the horizontal portion can extend toward the front side of the bracket, and the slot 9 can include a vertical slot and a horizontal slot, and the horizontal slot is connected to the bottom of the vertical slot, and the length of the vertical slot along the front-to-back direction is equal to or greater than the length of the horizontal portion of the hook 8 along the front-to-back direction, and the hook 8 can enter downward to the bottom of the vertical slot through the vertical slot, and then push the semi-cylindrical tube 7 forward, and the horizontal portion of the hook 8 is stuck in the horizontal slot, which can be limited. To prevent the longitudinal movement of the semi-cylindrical tube 7, the top of the semi-cylindrical tube 7 can be detachably connected by a buckle 14. When in use, the two semi-cylindrical tubes 7 can be removed from the bracket, and the rat can be placed between the two semi-cylindrical tubes 7. After the top of the two semi-cylindrical tubes 7 are connected, the buckle 14 is used, and then the hook 8 at the bottom is inserted into the slot 9 to achieve fixation, or the width of the slot 9 along the left and right directions can be greater than the thickness of the hook 8 along the left and right directions. When the rat needs to be fixed, it is only necessary to open the buckle 14 on the top of the semi-cylindrical tube 7, and then pull the semi-cylindrical tube 7 to both sides, the hook 8 slides in the slot 9, and after the rat is placed in, the two semi-cylindrical tubes 7 are pushed in opposite directions, and finally the buckle 14 on the top is buckled.

[0040] In practice, the driving device may include a motor 10 and a reduction gear 11 disposed between the motor 10 and the gear. The reduction gear 11 is a small gear having a diameter smaller than that of the driven gear 2 connected to the rat's hind limbs, thereby achieving a reduction effect.

[0041] Optionally, a plurality of hooks 12 may be provided on both sides of the top of the bracket along the front-rear direction. After the rat is fixed, the two forelimbs may be fixed to the hooks 12 on the left and right sides with a thin rope.

[0042] Preferably, two through holes 1 can be provided, which are respectively located on the left and right sides of the rear side of the rat fixing device, and the two hind limbs enter the interior of the bracket through their respective corresponding through holes 1.

[0043] During implementation, a locking device can be set between the second mobile frame 6 and the first mobile frame 5. The tightening device can be a locking bolt 13. A bolt hole is set on the vertical plate of the second mobile frame 6. The position of the bolt hole corresponds to the first mobile frame 5. After the locking bolt 13 is screwed into the bolt hole, it rests on the first mobile frame 5. When the height of the second mobile frame 6 needs to be adjusted, the locking bolt 13 is loosened. When it is adjusted to a suitable height, the locking bolt 13 can be tightened.

[0044] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art who is familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A rat passive exercise-induced Achilles tendon strain modeling device, characterized in that: The invention comprises a hollow bracket, a rat fixing device arranged on the top of the bracket, and a driving component arranged inside the bracket for driving the rat's hind limbs to move, wherein: A through hole (1) is provided at the top of the bracket, located at the rear side of the rat fixing device, for the hind limbs of the rat to pass through the inside of the bracket; The driving assembly comprises driven gears (2) arranged on the left and right sides of the bracket and a driving device for driving the driven gears (2) to rotate, the rotation axis of the driven gears (2) being along the left and right direction of the bracket, and hind limb fixing devices (3) being eccentrically arranged on opposite surfaces of the two driven gears (2), the hind limb fixing devices (3) being rotationally connected to the driven gears (2), and the rotation direction being along the left and right direction of the bracket; The driving assembly is connected to the bracket via a moving assembly, the moving assembly comprising a first moving frame (5) sliding along the front-rear direction of the bracket and a second moving frame (6) sliding along the upper-lower direction of the first moving frame (5), the driving device and the driven gear (2) are both connected to the second moving frame (6); The driving device comprises a motor (10) and a reduction gear (11) arranged between the motor (10) and the driven gear (2); the hind limb fixing device (3) is a columnar structure, and a hollow cylinder for the rat's hind limb to penetrate is arranged along the axis of the columnar structure; Hooks (12) are provided on the left and right sides of the top of the bracket; The through holes (1) are provided at two locations, respectively provided on the left and right sides of the rear side of the rat fixing device.

2. The rat passive exercise-induced Achilles tendon strain modeling device according to claim 1, characterized in that: A heating plate (4) is arranged at a position on the top of the support below the rat fixing device.

3. The rat passive exercise-induced Achilles tendon strain modeling device according to claim 1, characterized in that: The rat fixing device comprises two detachably connected semi-cylindrical cylinders (7), which, when buckled together, form a cylinder whose axis extends along the front-rear direction of the bracket, and the bottoms of the two semi-cylindrical cylinders (7) are detachably connected to the bracket.

4. The rat passive exercise-induced Achilles tendon strain modeling device according to claim 3, characterized in that: A hook (8) extending downward is provided at the bottom of the semi-cylindrical tube (7), and a slot (9) is provided at a position on the bracket corresponding to the hook (8), the hook (8) and the slot (9) are both L-shaped, and the width of the slot (9) in the left-right direction is greater than the thickness of the hook (8) in the left-right direction.

5. The rat passive exercise-induced Achilles tendon strain modeling device according to claim 1, characterized in that: A locking device is provided between the second movable frame (6) and the first movable frame (5).

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