A liquid target for the production of medical isotope F-18

Abstract

The present invention discloses a liquid target produced by medical isotope F-18, which uses water cooling instead of helium cooling to simplify the structure. Since the space of the beam limiting flange, the connecting flange, and the target body itself is fully utilized, no additional space is occupied separately, and water channels are opened on the beam limiting flange, the connecting flange, and the target body, and there is no need to specially arrange a helium cooling device between the front end of the target body and the beam limiting flange because of the need to cool the target window (Hawa film), so that the length of the liquid target is shortened and the structure is simplified; after eliminating one or more elements, the present invention still maintains all the original functions. When disassembling, it is only necessary to disassemble the first clamp, and all the components on the right side of the first clamp can be taken down as a whole and placed in a waste box in a very short time for radiation retreat. At the same time, the accelerator end will not be exposed to the air for a long time due to oxidation due to the long disassembly time, which effectively shortens the time that the staff is irradiated by the beam due to the inconvenience of disassembly and assembly.

Description

Technical Field

[0001] The invention belongs to the technical field of medical liquid targets, and in particular relates to a liquid target produced by using medical isotope F-18. Background Art

[0002] Short-lived radioactive isotopes such as 15O, 11C, 13N, and 18F produced by small medical cyclotrons are themselves components of the body. The above-mentioned nuclides produced by nuclear reactions of production targets are chemically synthesized into various radioactive drugs through synthesis module boxes and participate in human metabolism. The synthetic drug 18F-FDG of F-18 can simulate glucose metabolism. Using 18FDG, PET-CT imaging can detect primary and metastatic lesions of whole body tumors at an early stage, accurately determine whether they are benign or malignant, and thus correctly guide clinical treatment decisions.

[0003] Liquid target is a mechanism that completes nuclear reaction and produces positron nuclides. The beam enters the corresponding target cavity from the cyclotron accelerator outlet and bombards the target atomic nuclei with the corresponding nuclear reaction spectrum to obtain specific positron nuclides. This nuclide can be used in radiopharmaceutical production, material irradiation analysis, irradiation experiments, etc.

[0004] Liquid target structures are generally inseparable from beam duct flanges, beam limiting flanges, target windows, target bodies, and cooling devices. The beam duct flanges are used to lead out the beam, the beam limiting flanges are used to limit the amount of beam passing through, the target bodies are used to store liquid, and the cooling devices are used to cool the target windows, thereby shortening the time for target window replacement and extending the life of the target windows.

[0005] The prior art, such as Patent No. 201410205820.4, discloses an FDG target system, which has the problem of complex structure and inconvenient assembly and disassembly. Figure 7 As shown, since the target window 12 is cooled by a helium cooling device, and the position of the target window 12 is fixed and must be set at the front end of the target body, the helium cooling device must be placed between the two flanges. Since the target window 12 is fixed by the helium cooling device and connected to the helium cooling device, the target window 12 also serves as a seal for the helium cooling device to enter and exit, so two target windows are set; since the target window 12 is a consumable part that often needs to be disassembled, and the target window 12 is connected to the helium cooling device, the helium cooling device must be disassembled together when disassembling, and the helium cooling device has a complex structure and takes a long time to disassemble. In order to prevent the accelerator 6 from being exposed to the air too much and being oxidized to produce rust when disassembling the target window, a vacuum sealing film 7 is set at the accelerator end to maintain the vacuum degree of the accelerator. Another vacuum sealing film 7 is used to keep the target body liquid in a vacuum environment. In this way, the comparative document sets two sets of vacuum films, two sets of target windows 7, and a helium cooling device between two flanges. This makes the entire structure complex, bulky, with many consumables and high costs, and inconvenient to disassemble and assemble. Summary of the invention

[0006] The present invention aims at the deficiencies of the prior art and proposes a liquid target for the production of medical isotope F-18. The purpose is to solve the problems of the prior art liquid target, which has a complex structure, a large volume, a large number of consumables, a high cost, and inconvenient assembly and disassembly.

[0007] The present invention adopts the following technical solutions to solve its technical problems

[0008] A liquid target produced by medical isotope F-18, the liquid target is provided with a beam pipeline flange, a KF50 first clamp, a beam limiting flange, a KF50 second clamp, four fans, a four-fan connecting flange, a Hawa membrane, a target body and a water-cooled sealing flange in sequence along the direction of proton beam generated by an accelerator; one end of the KF50 first clamp is connected to the beam pipeline flange and the other end is connected to the beam limiting flange; one end of the KF50 second clamp is connected to the beam limiting flange and the other end is connected to the four-fan connecting flange; the four fans are arranged in the end face of the four-fan connecting flange close to the beam limiting flange and are fixedly connected to the end face of the four-fan connecting flange by screws; one end of the four-fan connecting flange is connected to the KF50 second clamp and the other end is connected to the target body; one end of the target body is connected to the four-fan connecting flange and the other end is connected to the water-cooled sealing flange;

[0009] Features:

[0010] Multiple flanges share one vacuum-isolating membrane, and the Hava membrane is used as both a vacuum-isolating membrane and a target membrane:

[0011] The front end of the target body is isolated from the vacuum by a Halva membrane, which also serves to isolate the liquid medicine. A water cooling groove is left at the rear end of the target body, which is finally sealed with a water cooling sealing flange and connected to the water circuit.

[0012] The beam limiting flange, the connecting flange and the target body are all provided with water cooling channels and water cooling grooves, which can be directly water-cooled to take away the heat.

[0013] The beam-limiting flange and the four-leaf connecting flange are connected by a ferrule-type vacuum seal, which is convenient for installation and disassembly and protects personnel safety.

[0014] The beam-limiting flange and the four-fan connecting flange respectively have two parallel channels, one water inlet channel and one water outlet channel, on their respective side end faces perpendicular to the beam direction and outside the beam channel diameter, and one channel is respectively opened on the other side end faces perpendicular to the two channels to connect the inlet and outlet channels and have a certain distance from the inlet and outlet holes, and plugs are added to seal the side holes.

[0015] The beam channels of the beam limiting flange and the four-sector connecting flange are tapered channels, which are arranged from large to small along the beam line direction, thereby adjusting the beam spot size to be the same as the circumferential size of the target body slot, so that the beam is fully utilized and a high amount of isotopes are produced;

[0016] The target body has a fine structure, and two circular holes are symmetrically opened on the side wall of the target body at 180 degrees. The upper hole is connected to the high-purity nitrogen and the pressure gauge, and the lower hole is connected to the liquid medicine pipeline. The front end surface of the target body is provided with a liquid medicine cavity to put a quantitative liquid medicine, and the rear end surface of the target body is provided with a water cooling groove, which is composed of a plurality of transverse grooves and longitudinal grooves. There are a plurality of parallel longitudinal grooves in the middle of the two transverse grooves. The plurality of transverse grooves and longitudinal grooves increases the water cooling area and can take away a large amount of heat. The high-purity nitrogen is used for liquid medicine transportation and target cleaning, and the pressure gauge is used to observe the pressure changes in the target body in real time.

[0017] The beam pipeline flange is made of insulating high temperature resistant material, is screwed to the front accelerator lead pipeline, and is connected to the beam limiting flange at the rear end by a KF50 first clamp.

[0018] The target body is made of niobium, which can withstand the bombardment of a large beam and is not prone to deformation and impurities. The diameter of the target body is smaller than the diameter of the flanges on both sides. The front end face and the rear end face of the target body can be sealed by using the end faces of the flanges on both sides: the flanges on both sides are directly connected by screws around the target body to contain the target body and achieve sealing, thereby reducing the overall size of the target body.

[0019] The target body medicine liquid cavity is a semi-cylindrical rectangular cavity, and the medicine liquid enters from the hole on the side wall of the target body corresponding to one end of the semi-cylinder. Nitrogen is introduced into the medicine liquid from the hole on the side wall of the target body corresponding to one end of the rectangle, and the medicine liquid containing F-18 ions is blown out through the hole on the side wall of the target body corresponding to one end of the semi-cylinder; the diameter of the target body semi-cylindrical cavity is the diameter of the beam spot.

[0020] The surfaces of the KF50 first clamp, the beam limiting flange, the KF50 second clamp, and the four-fan connecting flange are all coated with aluminum oxide, so that each component is insulated from other components, making the four-fan beam size and direction measured more accurately.

[0021] Advantages and effects of the present invention

[0022] 1. The present invention makes full use of the space between the beam limiting flange, the connecting flange and the target body to set up water cooling channels and water cooling grooves to take away the heat, without the need to set up a separate helium cooling device. Compared with the prior art, the present invention omits one or more elements (for example, omits two vacuum membranes, two sets of target membranes, and a helium cooling device between two sets of target windows), while still maintaining all the original functions, and thus has outstanding substantive characteristics and significant progress.

[0023] 2. The present invention ingeniously utilizes the disassembly of the clamp to replace the disassembly of the helium cooling device, and achieves an unexpected effect: the beam pipe flange and the beam limiting flange are connected, and only the first clamp needs to be disassembled during disassembly, and all the components on the right side of the first clamp can be taken down as a whole and put into a waste box for radiation retreat in a very short time. At the same time, the accelerator end will not be exposed to the air for a long time due to oxidation due to the long disassembly time, which effectively shortens the time that the staff is irradiated by the beam due to the inconvenience of disassembly and assembly.

[0024] 3. The present invention designs the beam channels of the pipeline flange and the beam-limiting flange as tapered channels, so that when the beam passes through the flange inlet, the beam will not accumulate at the flange inlet because the diameter of the inlet is smaller than the diameter of the beam. The tapered channel is used to evenly distribute the heat to the tapered channel wall when the beam passes through, thereby reducing the heat of the beam pipeline. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 Front view of the liquid target produced for the medical isotope F-18;

[0026] Figure 2 Explosion diagram of liquid target produced for medical isotope F-18;

[0027] Figure 3 It is a water cooling groove on the target body;

[0028] Figure 4 It is a water cooling groove on the limiting flange;

[0029] Figure 5 It is the water cooling groove on the connecting flange;

[0030] Figure 6 This is a flow chart of the liquid target transport system;

[0031] Figure 7 This is a structural diagram of the target system in the prior art.

[0032] In the figure: 1: beam pipe flange; 2: KF50 clamp; 3: O-ring; 4: beam limiting flange; 5: four-leaf connecting flange; 6: target body; 7: water-cooling sealing flange; 8: M6 screw; 9: four leaves; 10: ceramic insulating gasket; 11: Hava membrane; 12: screw. DETAILED DESCRIPTION

[0033] Design principle of the present invention

[0034] 1. The present invention uses water cooling instead of helium cooling to simplify the structure. Since the space of the beam limiting flange, the connecting flange, and the target body is fully utilized, no additional space is occupied separately, and water channels are opened on the beam limiting flange, the connecting flange, and the target body, and there is no need to specially arrange a helium cooling device between the front end of the target body and the beam limiting flange because the target window (Hava film) needs to be cooled, so that the length of the liquid target is shortened and the structure is simplified; at the same time, the clamp is connected to the beam pipeline at the accelerator end, and the clamp is very easy to disassemble and the disassembly time is very short, so that the accelerator is exposed to the air for a very short time. After the clamp is disassembled, a sealing flange can be immediately installed to vacuum seal the accelerator, and there is no need to specially set a vacuum film to prevent oxidation on the end face of the accelerator; at the same time, the present invention uses the Hava film to achieve dual-purpose of one film. Since the Hava film itself has no impurities, the beam will not be activated due to the impurities of the Hava film itself when passing through, and the pollution generated after activation will bring the pollution to the target body Chinese medicine liquid. At the same time, the Hava film itself is also used as a vacuum sealing film, thereby achieving dual-purpose of one film and further simplifying the structure.

[0035] 2. Since the Halva membrane is connected to the four connecting flanges and the target body through the sealing rings on the left and right sides, and the sealing rings on the left and right sides are recessed in the end faces at both ends, the Halva membrane can be close to the end faces of the flanges on both sides, and the heat can be taken away through the water cooling pipes of the flanges, without the need to set up a separate helium cooling device for the Halva membrane.

[0036] 3. The principle of setting the beam channel inside the flange as a conical channel. The beam channels of the beam-limiting flange and the four-fan connecting flange are both conical channels. The beam channel inside each flange forms a conical channel from large to small along the beam direction. The purpose of setting the conical channel is to prevent the beam from being intercepted at the entrance of the flange because the aperture at the entrance of the flange is smaller than the diameter of the beam, causing the beam to accumulate and generate heat. The aperture at the entrance of the flange is close to the diameter of the beam drawn out from the accelerator, and the diameter at the exit of the flange is close to the actual required diameter. After the beam enters the conical channel of the flange, as the diameter of the channel gradually decreases, the beam is evenly distributed on the wall of the conical channel, so that the heat is evenly dissipated. When the beam is led out from the beam pipe flange and enters the four-fan connecting flange of the next stage, it is still necessary to design a conical beam channel. This is because the beam will diverge after coming out of the previous flange. If the divergent beam group encounters a channel smaller than its diameter, it will accumulate at the entrance of the beam channel of the next stage flange. Therefore, the channel of the next stage flange is still designed to be a conical channel.

[0037] Based on the above principles, the present invention designs a liquid target produced by medical isotope F-18.

[0038] A liquid target produced by using medical isotope F-18 Figure 2As shown, the liquid target is provided with a beam pipeline flange 1, a KF50 first clamp 2-1, a beam limiting flange 4, a KF50 second clamp 2-2, four fans 9, a four-fan connecting flange 5, a Hava membrane 11, a target body 6 and a water-cooled sealing flange 7 in sequence along the direction of the proton beam generated by the accelerator; one end of the KF50 first clamp 2-1 is connected to the beam pipeline flange 1, and the other end is connected to the beam limiting flange 4; one end of the KF50 second clamp 2-2 is connected to the beam limiting flange 4, and the other end is connected to the four-fan connecting flange 5; the four fans 9 are arranged in the end surface of the four-fan connecting flange 5 close to the beam limiting flange 4, and are fixedly connected to the end surface of the four-fan connecting flange 5 by screws; one end of the four-fan connecting flange 5 is connected to the KF50 second clamp 2-2, and the other end is connected to the target body 6; one end of the target body 6 is connected to the four-fan connecting flange 5, and the other end is connected to the water-cooled sealing flange 7;

[0039] Its features are:

[0040] Multiple flanges share one vacuum-isolating membrane, and the Hava membrane is used as both a vacuum-isolating membrane and a target membrane:

[0041] The front end of the target body is isolated from the vacuum by a Halva membrane, which also serves to isolate the liquid medicine. A water cooling groove is left at the rear end of the target body, which is finally sealed with a water cooling sealing flange and connected to the water circuit.

[0042] The beam limiting flange, the connecting flange and the target body are all provided with water cooling channels and water cooling grooves, which can be directly water-cooled to take away the heat.

[0043] The beam-limiting flange and the four-leaf connecting flange are connected by a ferrule-type vacuum seal, which is convenient for installation and disassembly and protects personnel safety.

[0044] The beam-limiting flange and the four-fan connecting flange respectively have two parallel channels, one water inlet channel and one water outlet channel, on their respective side end faces perpendicular to the beam direction and outside the beam channel diameter, and one channel is respectively opened on the other side end faces perpendicular to the two channels to connect the inlet and outlet channels and have a certain distance from the inlet and outlet holes, and plugs are added to seal the side holes.

[0045] The beam channels of the beam limiting flange and the four-sector connecting flange are tapered channels, which are arranged from large to small along the beam line direction, thereby adjusting the beam spot size to be the same as the circumferential size of the target body slot, so that the beam is fully utilized and a high amount of isotopes are produced;

[0046] The target body has a fine structure, and two circular holes are symmetrically opened on the side wall of the target body at 180 degrees. The upper hole is connected to the high-purity nitrogen and the pressure gauge, and the lower hole is connected to the liquid medicine pipeline. The front end surface of the target body is provided with a liquid medicine cavity to put a quantitative liquid medicine, and the rear end surface of the target body is provided with a water cooling groove, which is composed of a plurality of transverse grooves and longitudinal grooves. There are a plurality of parallel longitudinal grooves in the middle of the two transverse grooves. The plurality of transverse grooves and longitudinal grooves increases the water cooling area and can take away a large amount of heat. The high-purity nitrogen is used for liquid medicine transportation and target cleaning, and the pressure gauge is used to observe the pressure changes in the target body in real time.

[0047] The beam pipeline flange is made of insulating high temperature resistant material, is screwed to the front accelerator lead pipeline, and is connected to the beam limiting flange at the rear end by a KF50 first clamp.

[0048] The material of the target body is niobium, which can withstand the bombardment of a large beam and is not prone to deformation and impurities; the diameter of the target body is smaller than the diameter of the flanges on both sides, and the front end face and the rear end face of the target body can be sealed by using the end faces of the flanges on both sides: the flanges on both sides are directly connected by screws around the target body to contain the target body and achieve sealing, thereby reducing the overall size of the target body.

[0049] The target body medicine liquid cavity is a semi-cylindrical rectangular cavity, and the medicine liquid enters from the hole on the side wall of the target body corresponding to one end of the semi-cylinder. Nitrogen is introduced into the medicine liquid from the hole on the side wall of the target body corresponding to one end of the rectangle, and the medicine liquid containing F-18 ions is blown out through the hole on the side wall of the target body corresponding to one end of the semi-cylinder; the diameter of the target body semi-cylindrical cavity is the diameter of the beam spot.

[0050] Additional notes:

[0051] The purpose of designing the drug liquid to be blown out from the hole at one end of the semi-cylinder on the side wall of the target body is that the inner wall of the semi-circle is smooth, the drug liquid is not easy to remain on the inner wall of the semi-circle, and the drug liquid can be blown out completely.

[0052] Example of target design: The diameter of the target semi-cylindrical cavity is 14mm, the depth is 10mm, and the rectangular cavity is 14mm long, 10mm wide, and 10mm high. It can hold 1.7-2ml of liquid medicine. In order to make full use of the beam and maximize economy, 1.75ml can be loaded; the semi-cylindrical rectangular groove design is convenient for liquid medicine storage and transportation.

[0053] The surfaces of the KF50 first clamp, the beam limiting flange, the KF50 second clamp, and the four-fan connecting flange are all coated with aluminum oxide, so that each component is insulated from other components, making the four-fan beam size and direction measured more accurately.

[0054] Additional notes:

[0055] 1. The sealing rings on both sides of the Halva membrane are respectively embedded in the sealing ring grooves of the four connecting flanges on both sides and the sealing ring grooves of the embedded target body, so that the Halva membrane can be close to the flange end faces at both ends, and its own heat is taken away by the water cooling pipes in the flanges on both sides through heat transfer.

[0056] 2. The water cooling setting of the target body is as follows Figure 2 , Figure 3 As shown, Figure 2 There are two holes in the middle of the water cooling flange 7, one water inlet hole and one water outlet hole. The water inlet hole corresponds to Figure 3 At one end of the two strips of the target sealing groove, the water outlet hole corresponds to the other end of the other strip of the target sealing groove at a 45-degree diagonal angle, so that water enters from the inlet end of the target sealing groove and then passes through multiple tooth-shaped channels to reach the outlet end of the sealing groove. The inlet end is located at a 45-degree diagonal position of the outlet end.

[0057] Example 1: Production process of liquid target Figure 6 Shown

[0058] 1. Ventilation connected to 4UW-1 (vent), ventilation connected to ASVO, ventilation connected to 4MWE=A-1 (peristaltic pump);

[0059] 2. Start peristaltic pump A to pump oxygen-enriched water into the liquid target chamber;

[0060] 3. After injection, turn off peristaltic pump A and ASVO;

[0061] 4. Ventilation connects to the vent valve 4UW-2 (blocked),

[0062] 5. Ventilation connection 4MWE=A-2 (blocking);

[0063] 6. Turn on the beam, and adjust the beam center position to the center of the target through the measurement signals of the four fans installed in front of the target and the measurement signals of the target itself. After the beam irradiates the oxygen-rich water for about 2 hours, observe the pressure gauge reading at any time and turn off the beam;

[0064] 7. Ventilation connects product valve 4MWE=B-3 (synthesis box);

[0065] 8. Ventilation connected 4MWE=A-4 (product valve)

[0066] 9. Ventilate 4UW-3 and ASVO with high-purity nitrogen (lower the pressure, do not break the liquid column), transport the irradiated oxygen-rich water to the radiochemical chamber, and test the activity;

[0067] 10. Ventilation is connected to 4UW-4 (blocked), ventilation is connected to product valve 4MWE=B-4 (blocked), ventilation is connected to 4MWE=A-3 (deionized water);

[0068] 11. Ventilate and connect 4UW-1 (degassing) to start peristaltic pump B to pump deionized water into the liquid target chamber;

[0069] 12. Fill the liquid target chamber with deionized water, turn off the peristaltic pump B, connect 4MWE=A-4 (product valve) and 4MWE=B-1 (waste liquid tank) for ventilation, connect 4UW-3 to pass nitrogen for cleaning, and discharge the waste liquid into the waste liquid tank;

[0070] 13. Repeat steps 10-12, and rinse the liquid target chamber with deionized water for multiple times until the activity meter measurement value meets the standard;

[0071] 14. Repeat steps 1-13 to continue drug production.

[0072] 15. If there is no production, connect the ventilation to 4MWE=A-1 (peristaltic pump), reverse the peristaltic pump A, introduce nitrogen to collect the oxygen-enriched water in the pipeline into the oxygen-enriched water bottle, and finally stop the peristaltic pump, connect the ventilation to 4MWE=A-2 (plugging), connect 4UW-4 (plugging), and close ASVO.

[0073] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A liquid target produced by medical isotope F-18, the liquid target being provided with a beam pipeline flange, a KF50 first clamp, a beam limiting flange, a KF50 second clamp, four leaves, a four-leaf connecting flange, a Hawa membrane, a target body and a water-cooled sealing flange in sequence along the direction of proton beam generated by an accelerator; one end of the KF50 first clamp is connected to the beam pipeline flange and the other end is connected to the beam limiting flange; one end of the KF50 second clamp is connected to the beam limiting flange and the other end is connected to the four-leaf connecting flange; the four leaves are arranged in the end face of the four-leaf connecting flange close to the beam limiting flange and are fixedly connected to the end face of the four-leaf connecting flange by screws; one end of the four-leaf connecting flange is connected to the KF50 second clamp and the other end is connected to the target body; one end of the target body is connected to the four-leaf connecting flange and the other end is connected to the water-cooled sealing flange; Features: Multiple flanges share one vacuum-isolating membrane, and the Hava membrane is used as both a vacuum-isolating membrane and a target membrane: The front end of the target body is isolated from the vacuum by a Halva membrane, which also serves to isolate the liquid medicine. A water cooling groove is left at the rear end of the target body, which is finally sealed with a water cooling sealing flange and connected to the water circuit. The beam limiting flange, the connecting flange and the target body are all provided with water cooling channels and water cooling grooves, which can be directly water-cooled to take away the heat; The beam-limiting flange and the four-leaf connecting flange are connected by a ferrule-type vacuum seal; The beam limiting flange and the four-span connecting flange respectively have two parallel channels, one water inlet channel and one water outlet channel, on their respective side end faces perpendicular to the beam direction and outside the beam channel diameter, and one channel is respectively opened on the other side end faces perpendicular to the two channels to connect the water inlet and outlet channels and have a certain distance from the water inlet and water outlet, and plugs are added to seal the side holes; The beam channels of the beam limiting flange and the four-sector connecting flange are tapered channels, which are arranged from large to small along the beam line direction, thereby adjusting the beam spot size to be the same as the circumferential size of the target body slot, so that the beam is fully utilized and a high amount of isotopes are produced; The surfaces of the KF50 first clamp, the limiting flange, the KF50 second clamp, and the four-leaf connecting flange are all coated with aluminum oxide, so that each component is insulated from other components.

2. The liquid target produced by the medical isotope F-18 according to claim 1, characterized in that: Two circular holes are symmetrically opened at 180 degrees on the side wall of the target body, the upper hole is connected to high-purity nitrogen and a pressure gauge, and the lower hole is connected to a liquid medicine pipeline; a liquid medicine cavity is opened on the front end surface of the target body to put a quantitative liquid medicine into, and a water cooling groove is opened on the rear end surface of the target body, the water cooling groove is composed of a plurality of transverse grooves and longitudinal grooves, and a plurality of parallel longitudinal grooves are arranged between the two transverse grooves. The plurality of transverse grooves and longitudinal grooves increase the water cooling area and can take away a large amount of heat; the high-purity nitrogen is used for liquid medicine transportation and target cleaning, and the pressure gauge is used for real-time observation of pressure changes in the target body.

3. The liquid target produced by the medical isotope F-18 according to claim 1, characterized in that: The beam pipeline flange is made of insulating high temperature resistant material, is screwed to the front accelerator lead pipeline, and is connected to the beam limiting flange at the rear end by a KF50 first clamp.

4. The liquid target produced by the medical isotope F-18 according to claim 1, characterized in that: The target body is made of niobium, and its diameter is smaller than the diameter of the flanges on both sides. The front end face and the rear end face of the target body are sealed by using the end faces of the flanges on both sides: the flanges on both sides are directly connected by screws around the target body to contain the target body to achieve sealing, thereby reducing the overall size of the target body.

5. The liquid target produced by the medical isotope F-18 according to claim 2, characterized in that: The target body medicine liquid cavity is a semi-cylindrical rectangular cavity, and the medicine liquid enters from the hole on the side wall of the target body corresponding to one end of the semi-cylinder. Nitrogen is introduced into the medicine liquid from the hole on the side wall of the target body corresponding to one end of the rectangle, and the medicine liquid containing F-18 ions is blown out through the hole on the side wall of the target body corresponding to one end of the semi-cylinder; the diameter of the target body semi-cylindrical cavity is the diameter of the beam spot.

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