Vibration device and analysis method

Abstract

The vibration device (10) of the present invention vibrates a microporous plate (30) having a plurality of recesses into which a sample can be injected. The vibration housing (1) is configured to be able to purge the interior of the housing with dry gas. The vibration mechanism (6) is configured to be accommodated in the vibration housing (1) and vibrates the microporous plate (30) moved into the vibration housing (1). The vibration housing (1) includes: an inlet (4) for dry gas to flow in; an outlet (5) for gas in the vibration housing (1) to flow out; and an opening and closing door (8) for moving the microporous plate (30) into the vibration housing (1).

Description

Technical Field

[0001] The present invention relates to a vibration device and an analysis method using the vibration device. Background Art

[0002] In the past, there are known devices for stirring a sample in a microplate by vibrating it. For example, in Patent Document 1 (Japanese Patent Publication No. 2014-77638), there is described a device having a plate-mounting portion and a supporting unit, wherein the plate-mounting portion has a plate-mounting surface on which a plate-shaped container is detachably mounted, the plate-shaped container having a containing portion for containing an object to be stirred or mixed, and the supporting unit supports the plate-mounting portion in a swingable manner.

[0003] Prior art literature

[0004] Patent Literature

[0005] Patent Document 1: Japanese Patent Application Publication No. 2014-77638 Summary of the invention

[0006] Problem that the invention aims to solve

[0007] However, there is no cover on the upper surface of the microplate, so the sample in the well of the microplate is vibrated and stirred while being exposed to the ambient air. When a sample with high water absorption is vibrated in a high humidity environment, the sample is stirred while sucking in the surrounding moisture. On the other hand, when the microplate is covered, a drive unit for automatically removing the cover is required.

[0008] Therefore, an object of the present invention is to provide a vibration device capable of stirring a sample in a well of a microplate without covering the microplate and without involving surrounding moisture, and an analysis method using such a vibration device.

[0009] Solutions for solving problems

[0010] The present invention is a vibration device that vibrates a plate having a plurality of recesses into which a sample can be injected, the vibration device comprising: a housing capable of being purged with a dry gas; and a vibration mechanism that is contained in the housing and configured to vibrate the plate carried into the housing. The housing includes: an inlet for the dry gas to flow in; an outlet for the gas in the housing to flow out; and an opening and closing door for carrying the plate into the housing.

[0011] Preferably, a solenoid valve is provided, and the solenoid valve is arranged between the supply source of the dry gas and the suction port.

[0012] Preferably, a flow rate regulating valve is provided, and the flow rate regulating valve is arranged between the supply source of the drying gas and the suction port.

[0013] Preferably, a humidity sensor is provided, and the humidity sensor measures the humidity in the housing.

[0014] Preferably, a control unit is provided that records the change over time in the humidity measured by the humidity sensor.

[0015] Preferably, a control unit is provided that starts purging the inside of the housing with a dry gas before the plate is carried into the housing.

[0016] Preferably, a humidity sensor is provided to measure the humidity in the housing. The control unit moves the panel into the housing through the opening and closing door after the humidity in the housing becomes below a threshold value after the housing starts to be purged.

[0017] Preferably, the control unit moves the panel into the casing through the opening and closing door after a predetermined time has elapsed since the start of purging the inside of the casing.

[0018] Preferably, the control unit starts the vibration mechanism to vibrate after the humidity in the casing becomes equal to or lower than a threshold value after the panel is loaded into the casing.

[0019] Preferably, the control unit starts the vibration mechanism to vibrate after a predetermined time has passed since the plate was carried into the housing.

[0020] Preferably, a solenoid valve is provided between the supply source of the dry gas and the suction port. The control unit starts the vibration mechanism to vibrate and closes the solenoid valve to complete the purging of the inside of the casing.

[0021] Preferably, the drying gas is nitrogen.

[0022] The present invention is an analysis method, which is an analysis method using a vibration device, wherein the vibration device comprises: a shell capable of purging the inside of the shell with dry gas; and a vibration mechanism contained in the shell, wherein the analysis method comprises the following steps: a centrifugation step, in which a plate having a plurality of recesses into which a sample is injected is centrifuged by a centrifuge; in parallel with the centrifugation step, starting to purge the inside of the shell with dry gas; after the centrifugation, adding drugs into the recesses of the plate; after the humidity in the shell reaches below a threshold after the centrifugation, moving the plate into the shell; and after the humidity in the shell reaches below a threshold after the plate is moved into the shell, vibrating the plate using the vibration mechanism.

[0023] Effects of the Invention

[0024] According to the present invention, the sample in the well of the microplate can be stirred without covering the microplate and without involving surrounding moisture. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1It is a diagram showing the structure of the vibration device 10 according to the first embodiment.

[0026] Figure 2 It is a figure which shows the microplate 30.

[0027] Figure 3 1 is a flowchart showing the operation process of the vibration device 10 according to the first embodiment.

[0028] Figure 4 1 is a flowchart showing the operation process of the vibration device 10 according to the second embodiment.

[0029] Figure 5 It is a diagram showing the structure of a vibration device 110 according to the third embodiment.

[0030] Figure 6 : is a flowchart showing the operation process of the vibration device 110 according to the third embodiment.

[0031] Figure 7 : is a flowchart showing the operation process of the vibration device 110 according to the fourth embodiment.

[0032] Figure 8 : is a flowchart showing the operation process of the vibration device 110 according to the fifth embodiment.

[0033] Fig. 9 It is a graph showing the change of humidity in the vibration housing 1 with time.

[0034] Fig.10 1 is a flowchart showing the procedure of the analysis method using the vibration device 110 according to the sixth embodiment.

[0035] Fig.11 It is a diagram showing an example of the hardware configuration of the control unit 40 . DETAILED DESCRIPTION

[0036] Hereinafter, embodiments will be described with reference to the drawings.

[0037] [First embodiment]

[0038] Figure 1 It is a diagram showing the structure of the vibration device 10 according to the first embodiment.

[0039] Reference Figure 1 The vibration device 10 includes a vibration housing 1 , an electromagnetic valve 2 , a flow rate regulating valve 7 , a vibration mechanism 6 , and a control unit 40 .

[0040] A vibration mechanism 6 is accommodated in the vibration housing 1. The vibration housing 1 has an inlet 4, an outlet 5, and an opening and closing door 8. The vibration housing 1 is formed of a glass plate serving as a wall except for the inlet 4, the outlet 5, and the opening and closing door 8.

[0041] The suction port 4 is connected to the flow rate regulating valve 7 via piping. Nitrogen flows into the vibration housing 1 from the suction port 4.

[0042] The discharge port 5 is connected to a thin tube 31. Nitrogen is discharged from the vibration housing 1 to the tube 31 through the discharge port 5. The tube 31 has a thin cylindrical structure, so that even after the vibration housing 1 is purged, the gas outside the vibration housing 1 does not flow into the vibration housing 1 through the discharge port 5.

[0043] The microplate 30 can be placed on the base of the vibration mechanism 6. The vibration mechanism 6 vibrates under the control of the control unit 40, thereby vibrating the microplate 30 to stir the sample in the well of the microplate 30. The rotation speed of the vibration by the vibration mechanism 6 can be adjusted by the control unit 40.

[0044] The solenoid valve 2 is connected to a nitrogen supply source 20 through piping. The nitrogen supply source 20 is composed of a nitrogen generator, a nitrogen tank, or a nitrogen centralized piping. The nitrogen supply source 20 supplies nitrogen as a dry gas. When the solenoid valve 2 is opened, the nitrogen released from the nitrogen supply source 20 is transported to the vibration housing 1.

[0045] The flow regulating valve 7 is connected to the electromagnetic valve 2 through piping. The flow regulating valve 7 is composed of, for example, a flow meter with a needle valve. The flow regulating valve 7 adjusts the flow rate of nitrogen delivered from the nitrogen supply source 20 to the vibration housing 1. Thus, the time for the humidity in the vibration housing 1 to reach the target humidity can be adjusted.

[0046] The control unit 40 controls the electromagnetic valve 2 , the flow rate regulating valve 7 , the vibration mechanism 6 , and the opening and closing door 8 .

[0047] Figure 2 It is a figure which shows the microplate 30.

[0048] The microplate 30 has 96 wells. A sample is injected into each well. For example, when screening and analyzing early colorectal cancer, the sample includes cells, metabolites, and pyridine with high hygroscopicity.

[0049] Figure 3 1 is a flowchart showing the operation process of the vibration device 10 according to the first embodiment.

[0050] In step S101 , the control unit 40 opens the door 8 in the vibration housing 1 , carries the micro plate 30 into the vibration housing 1 , and places the micro plate 30 on the vibration mechanism 6 .

[0051] In step S102, the control unit 40 adjusts the flow rate of nitrogen from the nitrogen supply source 20 to the vibrating housing 1 by setting the opening of the flow regulating valve 7 to a default value or a user-specified value. The flow rate may be adjusted in consideration of the size of the vibrating housing 1, the time limit, and the like.

[0052] In step S103, the control unit 40 opens the electromagnetic valve 2. As a result, the gas in the vibration housing 1 is replaced with nitrogen. As a result, the vibration housing 1 can be kept at a low humidity.

[0053] In step S104 , the control unit 40 starts the vibration mechanism 6 to vibrate.

[0054] In step S105, the control unit 40 determines whether the time elapsed from the start of vibration is greater than or equal to the threshold value THA. If the time elapsed from the start of vibration is greater than or equal to the threshold value THA, the process proceeds to step S106. If the time elapsed from the start of vibration is less than the threshold value THA, the process returns to step S105.

[0055] In step S106 , the control unit 40 causes the vibration mechanism 6 to stop vibrating.

[0056] As described above, according to the present embodiment, after the vibration housing 1 is purged with nitrogen, the microplate 30 in the vibration housing 1 is vibrated, so that the sample can be prevented from being stirred in a high-humidity environment.

[0057] [Second embodiment]

[0058] In the second embodiment, before the microplate 30 is carried into the vibration housing 1 , the vibration housing 1 is pre-purged with nitrogen.

[0059] Figure 4 1 is a flowchart showing the operation process of the vibration device 10 according to the second embodiment.

[0060] In step S201 , the control unit 40 closes the opening and closing door 8 in the vibration housing 1 .

[0061] In step S202 , the control unit 40 adjusts the flow rate of nitrogen flowing from the nitrogen supply source 20 to the vibration housing 1 by setting the opening degree of the flow rate regulating valve 7 to a default value or a value designated by the user.

[0062] In step S203 , the control unit 40 opens the solenoid valve 2 .

[0063] In step S204, the control unit 40 determines whether the time elapsed from the opening of the electromagnetic valve 2 is greater than or equal to the threshold value THB. When the time elapsed from the opening of the electromagnetic valve 2 is greater than or equal to the threshold value THB, the process proceeds to step S205. When the time elapsed from the opening of the electromagnetic valve 2 is less than the threshold value THB, the process returns to step S204.

[0064] In step S205 , the control unit 40 opens the door 8 in the vibration housing 1 , carries the micro plate 30 into the vibration housing 1 , and places the micro plate 30 on the vibration mechanism 6 .

[0065] In step S206, the control unit 40 determines whether the time elapsed since the microplate 30 was carried into the vibration housing 1 is greater than or equal to the threshold value THC. When the time elapsed since the microplate 30 was carried into the vibration housing 1 is greater than or equal to the threshold value THC, the process proceeds to step S207. When the time elapsed since the microplate 30 was carried into the vibration housing 1 is less than the threshold value THC, the process returns to step S206.

[0066] In step S207 , the control unit 40 starts the vibration mechanism 6 to vibrate.

[0067] In step S208, the control unit 40 determines whether the time elapsed from the start of vibration is greater than or equal to the threshold value THA. If the time elapsed from the start of vibration is greater than or equal to the threshold value THA, the process proceeds to step S209. If the time elapsed from the start of vibration is less than the threshold value THA, the process returns to step S208.

[0068] In step S209 , the control unit 40 causes the vibration mechanism 6 to stop vibrating.

[0069] As described above, according to this embodiment, before the microporous plate 30 is moved into the vibration housing 1, the vibration housing 1 is pre-purged with nitrogen for a predetermined time (THC), thereby preventing the sample from being exposed to a high humidity environment not only during but also before the sample is vibrated.

[0070] [Third Embodiment]

[0071] In the third embodiment, the humidity in the vibration housing 1 is measured by providing a humidity sensor in the vibration housing 1 .

[0072] Figure 5 It is a diagram showing the structure of a vibration device 110 according to the third embodiment.

[0073] The vibration device 110 of the third embodiment Figure 1 The vibration device 10 of the third embodiment is different from the vibration device 10 of the first embodiment in that the vibration device 110 of the third embodiment includes a humidity sensor 3 .

[0074] The humidity sensor 3 is accommodated in the vibration housing 1 . The humidity sensor 3 measures the humidity in the vibration housing 1 , and outputs the measurement result to the control unit 40 .

[0075] Figure 6 : is a flowchart showing the operation process of the vibration device 110 according to the third embodiment.

[0076] In step S301 , the control unit 40 closes the opening and closing door 8 in the vibration housing 1 .

[0077] In step S302 , the control unit 40 adjusts the flow rate of nitrogen flowing from the nitrogen supply source 20 to the vibration housing 1 by setting the opening degree of the flow rate regulating valve 7 to a default value or a value designated by the user.

[0078] In step S303 , the control unit 40 opens the solenoid valve 2 .

[0079] In step S304, the control unit 40 starts recording a log of the humidity in the vibration housing 1 detected by the humidity sensor 3. By recording the humidity log, it is possible to check whether the humidity in the vibration process is appropriate when there is ambiguity in the analysis result.

[0080] In step S305, the control unit 40 determines whether the humidity in the vibration housing 1 detected by the humidity sensor 3 is less than the threshold value THD. If the humidity in the vibration housing 1 is less than the threshold value THD, the process proceeds to step S306. If the humidity in the vibration housing 1 exceeds the threshold value THD, the process returns to step S305.

[0081] In step S306 , the control unit 40 opens the door 8 in the vibration housing 1 , carries the micro plate 30 into the vibration housing 1 , and places the micro plate 30 on the vibration mechanism 6 .

[0082] In step S307 , the control unit 40 starts the vibration mechanism 6 to vibrate.

[0083] In step S308, the control unit 40 determines whether the time elapsed from the start of vibration is greater than or equal to the threshold value THA. If the time elapsed from the start of vibration is greater than or equal to the threshold value THA, the process proceeds to step S309. If the time elapsed from the start of vibration is less than the threshold value THA, the process returns to step S308.

[0084] In step S309 , the control unit 40 causes the vibration mechanism 6 to stop vibrating.

[0085] As described above, according to the present embodiment, before the microporous plate 30 is moved into the vibration housing 1, the vibration housing 1 is pre-purged with nitrogen until the humidity of the vibration housing 1 reaches a certain value (threshold THD), thereby preventing the sample from being exposed to a high humidity environment not only during the vibration of the sample but also before the vibration of the sample.

[0086] [Fourth Embodiment]

[0087] In the fourth embodiment, the humidity in the vibration housing 1 which has increased due to opening the door 8 of the vibration housing 1 in order to carry the micro plate 30 into the vibration housing 1 is reduced.

[0088] Figure 7: is a flowchart showing the operation process of the vibration device 110 according to the fourth embodiment.

[0089] In step S401 , the control unit 40 closes the opening and closing door 8 in the vibration housing 1 .

[0090] In step S402 , the control unit 40 adjusts the flow rate of nitrogen flowing from the nitrogen supply source 20 to the vibration housing 1 by setting the opening degree of the flow rate regulating valve 7 to a default value or a value designated by the user.

[0091] In step S403 , the control unit 40 opens the solenoid valve 2 .

[0092] In step S404 , the control unit 40 starts recording a log of the humidity in the vibration housing 1 detected by the humidity sensor 3 .

[0093] In step S405, the control unit 40 determines whether the humidity in the vibration housing 1 detected by the humidity sensor 3 is less than the threshold value THD. If the humidity in the vibration housing 1 is less than the threshold value THD, the process proceeds to step S406. If the humidity in the vibration housing 1 exceeds the threshold value THD, the process returns to step S405.

[0094] In step S406 , the control unit 40 opens the door 8 in the vibration housing 1 , carries the micro plate 30 into the vibration housing 1 , and places the micro plate 30 on the vibration mechanism 6 .

[0095] In step S407, the control unit 40 determines whether the humidity in the vibration housing 1 detected by the humidity sensor 3 is less than the threshold value THE. When the humidity in the vibration housing 1 is less than the threshold value THE, the process proceeds to step S408. When the humidity in the vibration housing 1 exceeds the threshold value THE, the process returns to step S407. The threshold value THE may be the same as the threshold value THD in step S405 in the pre-purge.

[0096] In step S408 , the control unit 40 starts the vibration mechanism 6 to vibrate.

[0097] In step S409, the control unit 40 determines whether the time elapsed from the start of vibration is greater than or equal to the threshold value THA. If the time elapsed from the start of vibration is greater than or equal to the threshold value THA, the process proceeds to step S410. If the time elapsed from the start of vibration is less than the threshold value THA, the process returns to step S409.

[0098] In step S410 , the control unit 40 causes the vibration mechanism 6 to stop vibrating.

[0099] As described above, the vibration housing 1 is pre-purged with nitrogen before step S406, but in step S406, the door 8 of the vibration housing 1 is opened to move the microplate 30 into the vibration housing 1, thereby increasing the humidity in the vibration housing 1. In this embodiment, the increased humidity in the vibration housing 1 can be reduced before the vibration housing 1 is vibrated by step S407.

[0100] [Fifth Embodiment]

[0101] Figure 8 : is a flowchart showing the operation process of the vibration device 110 according to the fifth embodiment.

[0102] In step S501 , the control unit 40 closes the opening and closing door 8 in the vibration housing 1 .

[0103] In step S502 , the control unit 40 adjusts the flow rate of nitrogen flowing from the nitrogen supply source 20 to the vibration housing 1 by setting the opening degree of the flow rate regulating valve 7 to a default value or a value designated by the user.

[0104] In step S503 , the control unit 40 opens the solenoid valve 2 .

[0105] In step S504 , the control unit 40 starts recording a log of the humidity in the vibration housing 1 detected by the humidity sensor 3 .

[0106] In step S505, the control unit 40 determines whether the humidity in the vibration housing 1 detected by the humidity sensor 3 is less than the threshold value THD. If the humidity in the vibration housing 1 is less than the threshold value THD, the process proceeds to step S506. If the humidity in the vibration housing 1 exceeds the threshold value THD, the process returns to step S505.

[0107] In step S506 , the control unit 40 opens the door 8 in the vibration housing 1 , carries the micro plate 30 into the vibration housing 1 , and places the micro plate 30 on the vibration mechanism 6 .

[0108] In step S507, the control unit 40 determines whether the humidity in the vibration housing 1 detected by the humidity sensor 3 is less than the threshold value THE. If the humidity in the vibration housing 1 is less than the threshold value THE, the process proceeds to step S508. If the humidity in the vibration housing 1 exceeds the threshold value THE, the process returns to step S507.

[0109] In step S508, the control unit 40 closes the electromagnetic valve 2. Thus, the release of nitrogen from the nitrogen supply source 20 is stopped. Since the discharge port 5 is connected to the thin cylindrical tube 31, even if the purge is stopped, the gas outside the vibration housing 1 does not flow into the vibration housing 1. By stopping the release of nitrogen from the nitrogen supply source 20, the consumption of nitrogen can be reduced.

[0110] In step S509 , the control unit 40 starts the vibration mechanism 6 to vibrate.

[0111] In step S510, the control unit 40 determines whether the time elapsed from the start of vibration is greater than or equal to the threshold value THA. If the time elapsed from the start of vibration is greater than or equal to the threshold value THA, the process proceeds to step S511. If the time elapsed from the start of vibration is less than the threshold value THA, the process returns to step S510.

[0112] In step S511 , the control unit 40 causes the vibration mechanism 6 to stop vibrating.

[0113] Fig. 9 It is a graph showing the change of humidity in the vibration housing 1 with time.

[0114] exist Fig. 9 In the embodiment, the humidity in the vibration housing 1 is reduced from 56% to 30% by pre-purging. Thereafter, the door 8 of the vibration housing 1 is opened to carry the microporous plate 30 into the vibration housing 1, thereby increasing the humidity in the vibration housing 1 to slightly less than 40%. By continuing to purge (referred to as formal purge) after the microporous plate 30 is carried into the vibration housing 1, the humidity in the vibration housing 1 can be reduced to 30% in a shorter time than pre-purging. Thereafter, the solenoid valve 2 is closed and the vibration operation is started.

[0115] [Sixth Embodiment]

[0116] Fig.10 1 is a flowchart showing the procedure of the analysis method using the vibration device 110 according to the sixth embodiment.

[0117] In step S601, the microplate 30 having the wells into which the samples are injected is centrifuged in a vacuum environment by a centrifuge, so that the samples in the wells of the microplate 30 are turned into powder.

[0118] In step S602, the vibration housing 1 is pre-purged with nitrogen in parallel with the centrifugation process (centrifugation step). Figure 8 The processing of steps S501 to S504 is the same.

[0119] In step S603, if the centrifugation step is completed, the process proceeds to step S604, and if the centrifugation step is not completed, the process returns to step S603.

[0120] In step S604 , pyridine, a highly hygroscopic chemical, is added to the wells of the microplate 30 after centrifugation.

[0121] In step S605, the control unit 40 determines whether the humidity in the vibration housing 1 detected by the humidity sensor 3 is less than the threshold value THD. If the humidity in the vibration housing 1 is less than the threshold value THD, the process proceeds to step S606. If the humidity in the vibration housing 1 exceeds the threshold value THD, the process returns to step S605.

[0122] In step S606 , the control unit 40 opens the door 8 in the vibration housing 1 , carries the micro plate 30 into the vibration housing 1 , and places the micro plate 30 on the vibration mechanism 6 .

[0123] In step S607, the control unit 40 determines whether the humidity in the vibration housing 1 detected by the humidity sensor 3 is less than or equal to the threshold value THE. If the humidity in the vibration housing 1 is less than or equal to the threshold value THE, the process proceeds to step S608. If the humidity in the vibration housing 1 exceeds the threshold value THE, the process returns to step S607.

[0124] In step S608 , the control unit 40 closes the solenoid valve 2 .

[0125] In step S609 , the control unit 40 starts the vibration mechanism 6 to vibrate.

[0126] In step S610, the control unit 40 determines whether the time elapsed from the start of vibration is greater than or equal to the threshold value THA. If the time elapsed from the start of vibration is greater than or equal to the threshold value THA, the process proceeds to step S611. If the time elapsed from the start of vibration is less than the threshold value THA, the process returns to step S610.

[0127] In step S611 , the control unit 40 causes the vibration mechanism 6 to stop vibrating.

[0128] As described above, according to the present embodiment, the pre-purging of the vibration housing 1 is performed in parallel with the centrifugation step of the microplate 30 , so that the microplate 30 can be vibrated immediately after the centrifugation step is completed.

[0129] The present invention is not limited to the above-described embodiment, and includes, for example, the following modified examples.

[0130] (1) Dry gas

[0131] In the above-mentioned embodiment, the vibration housing 1 is purged with nitrogen, but the present invention is not limited thereto. The vibration housing 1 may be purged with other dry gases.

[0132] (2) Vibration

[0133] The vibration mechanism 6 may be set to vibrate at a fixed rotation speed or may be set to change the rotation speed. For example, the vibration mechanism may be set to rotate at a high speed for a first time after the vibration starts, and rotate at a low speed for a second time thereafter.

[0134] (3) Control unit

[0135] Fig.11 1 is a diagram showing an example of the hardware configuration of the control unit 40. The hardware of the control unit 40 includes a processor 1100 and a memory 1200 connected to the processor 1100 via a bus 1300. The control unit 40 is implemented by the processor 1100 such as a CPU (Central Processing Unit) executing a program stored in the memory 1200. In addition, a plurality of processors and a plurality of memories may cooperate to perform the functions of the above-mentioned components.

[0136] The embodiments disclosed this time should be considered in all respects as illustrative and non-restrictive. The scope of the present invention is indicated by the claims rather than the above description, and is intended to include all modifications within the meaning and scope equivalent to the claims.

[0137] Description of Reference Numerals

[0138] 1: Vibrating housing; 2: Solenoid valve; 3: Humidity sensor; 4: Inlet; 5: Exhaust port; 6: Vibrating mechanism; 7: Flow regulating valve; 8: Opening and closing door; 10, 110: Vibrating device; 20: Nitrogen supply source; 30: Microplate; 31: Tube; 40: Control unit; 1100: Processor; 1200: Memory; 1300: Bus.

Claims

1. A vibration device that vibrates a plate having a plurality of recesses into which a sample can be injected, The vibration device comprises: a housing capable of being purged with a dry gas; and a vibration mechanism, which is accommodated in the housing and is configured to vibrate the plate carried into the housing, in, The housing includes: an inlet for the dry gas to flow in; an outlet for the gas in the housing to flow out; and an opening and closing door for moving the plate into the housing. The vibration device also has: a humidity sensor that measures the humidity within the housing; and The control unit starts the vibration mechanism to vibrate after the humidity in the housing reaches or falls below a threshold value after the panel is loaded into the housing.

2. The vibration device according to claim 1, wherein The invention further includes an electromagnetic valve disposed between a supply source of the dry gas and the suction port.

3. The vibration device according to claim 1, wherein The invention further includes a flow rate regulating valve disposed between a supply source of the drying gas and the suction port.

4. The vibration device according to claim 1, wherein: The control unit records the change over time of the humidity measured by the humidity sensor.

5. The vibration device according to claim 1, wherein The control unit starts purging the inside of the housing with the dry gas before carrying the plate into the housing.

6. The vibration device according to claim 5, wherein: The control unit moves the panel into the housing through the opening and closing door after the humidity in the housing reaches or falls below a threshold value after the purging of the housing is started.

7. The vibration device according to claim 5, wherein: The control unit moves the panel into the casing through the opening and closing door after a predetermined time has passed since the start of purging the inside of the casing.

8. The vibration device according to claim 2, wherein: The control unit starts the vibration mechanism to vibrate, and closes the solenoid valve to complete purging the inside of the housing.

9. The vibration device according to claim 1, wherein: The drying gas is nitrogen.

10. An analysis method using a vibration device, the vibration device comprising: a housing capable of being purged with a dry gas; and a vibration mechanism accommodated in the housing, The analytical method comprises the following steps: a centrifugation step, centrifuging the plate having the plurality of depressions injected with the samples by a centrifuge; In parallel with the centrifuging step, starting to purge the interior of the housing with the dry gas; After the centrifugation step, adding a drug into the depression of the plate; After the humidity in the housing reaches below a threshold value after the centrifugation step, moving the plate into the housing; and After the panel is placed in the housing and the humidity in the housing reaches or falls below a threshold, the panel is vibrated by the vibration mechanism.

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