Application of Korean medicine prescription in preparation of medicines, health care products or foods for improving chronic fatty liver

Abstract

The invention provides a Korean medicine prescription and application thereof in preparation of medicines, foods or healthcare products for improving chronic alcoholic and non-alcoholic fatty liver. Particularly, the Korean medicine prescription is characterized by consisting of 15g of coix seeds, 15g of dried chestnuts, 10g of radish seeds, 5g of schisandra chinensis, 5g of radix ophiopogonis, 5gof rhizoma acori graminei, 5g of platycodon grandiflorum and 5g of ephedra. Taiyin stomach-regulating soup containing the Korean medicine prescription has an excellent protective effect on liver. TheKorean medicine prescription provided by the invention has the effects of reducing the fat accumulation degree of mice with chronic alcoholic and non-alcoholic fatty liver diseases and reducing the contents of ALT and AST in serum as well as the concentration of TG, so the Taiyin stomach-regulating soup has the effect of reducing fat accumulation of the alcoholic and non-alcoholic fatty liver diseases.

Description

technical field

[0001] The invention relates to a Korean medicine prescription and its application in the preparation of medicines, health care products or food for improving chronic fatty liver. Background technique

[0002] At present, liver disease has been listed as one of the important diseases causing death by the World Health Organization. More than 500,000 people die of liver disease every year in my country. The total number of patients with liver disease in my country accounts for about 10% of the total population, which has exceeded 200 million, and this number is still expanding. Liver cell damage caused by various factors can be manifested as: hepatic fatty degeneration, cholestasis, liver fibrosis, liver necrosis, liver cirrhosis, and liver cancer. In recent years, there have been more and more liver cell injuries caused by various reasons. Common liver injuries include: chemical liver injury, drug-induced liver injury, non-alcoholic liver injury and alcohol...

Examples

Embodiment 1

[0038] Establishment of alcoholic fatty liver animal model: C57BL / 6 mice were randomly divided into control feed group, alcohol feeding plus alcohol gavage group (hereinafter referred to as alcohol group), alcohol feeding plus alcohol gavage plus Taiyin Tiaowei Decoction large, medium and Small-dose group and alcohol feeding plus alcohol gavage plus Fuzhenghuayu positive control group. The administration components were Taiyin Tiaowei Decoction large, medium and small dose groups (50, 100 and 200 mg / kg) and the positive control group Fuzheng Huayu (750 mg / kg). The establishment process of the model is as follows: the normal group is given the control liquid feed, and the alcohol group and the treatment group are given the liquid alcohol feed 5 days after the liquid control feed is given, and the concentration of the alcohol feed is gradually increased from 1% to 5%, and from 1% to 4%. Each concentration of alcoholic diet was given for two days, followed by 5% liquid alcoholic ...

Embodiment 2

[0043] Establishment of non-alcoholic fatty liver animal model: C57BL / 6J mice were divided into normal control diet group, high-fat diet group, high-fat diet plus Taiyin Tiaowei Decoction large, medium and small dose groups, and high-fat diet plus Fuzheng Huayu decoction group positive control group. The model group was given 60% high-fat obesity model feed for 12 consecutive weeks, and the normal group was given control feed. The administration components were Taiyin Tiaowei Decoction large, medium and small dose groups (50, 100 and 200 mg / kg) and the positive control group Fuzheng Huayu (750 mg / kg). Drugs were administered once a day according to the requirements of each group, and body weight and food intake were recorded once a day after administration. On the last day, blood was collected from all mice by heart puncture, and the liver was dissected and separated. After the blood was centrifuged at 3000rpm, the serum was collected. The lobe of the liver was submerged in ...

technical field

[0001] The invention relates to a Korean medicine prescription and its application in the preparation of medicines, health care products or food for improving chronic fatty liver. Background technique

[0002] At present, liver disease has been listed as one of the important diseases causing death by the World Health Organization. More than 500,000 people die of liver disease every year in my country. The total number of patients with liver disease in my country accounts for about 10% of the total population, which has exceeded 200 million, and this number is still expanding. Liver cell damage caused by various factors can be manifested as: hepatic fatty degeneration, cholestasis, liver fibrosis, liver necrosis, liver cirrhosis, and liver cancer. In recent years, there have been more and more liver cell injuries caused by various reasons. Common liver injuries include: chemical liver injury, drug-induced liver injury, non-alcoholic liver injury and alcohol...

Examples

Embodiment 1

[0038] Establishment of alcoholic fatty liver animal model: C57BL / 6 mice were randomly divided into control feed group, alcohol feeding plus alcohol gavage group (hereinafter referred to as alcohol group), alcohol feeding plus alcohol gavage plus Taiyin Tiaowei Decoction large, medium and Small-dose group and alcohol feeding plus alcohol gavage plus Fuzhenghuayu positive control group. The administration components were Taiyin Tiaowei Decoction large, medium and small dose groups (50, 100 and 200 mg / kg) and the positive control group Fuzheng Huayu (750 mg / kg). The establishment process of the model is as follows: the normal group is given the control liquid feed, and the alcohol group and the treatment group are given the liquid alcohol feed 5 days after the liquid control feed is given, and the concentration of the alcohol feed is gradually increased from 1% to 5%, and from 1% to 4%. Each concentration of alcoholic diet was given for two days, followed by 5% liquid alcoholic ...

Embodiment 2

[0043] Establishment of non-alcoholic fatty liver animal model: C57BL / 6J mice were divided into normal control diet group, high-fat diet group, high-fat diet plus Taiyin Tiaowei Decoction large, medium and small dose groups, and high-fat diet plus Fuzheng Huayu decoction group positive control group. The model group was given 60% high-fat obesity model feed for 12 consecutive weeks, and the normal group was given control feed. The administration components were Taiyin Tiaowei Decoction large, medium and small dose groups (50, 100 and 200 mg / kg) and the positive control group Fuzheng Huayu (750 mg / kg). Drugs were administered once a day according to the requirements of each group, and body weight and food intake were recorded once a day after administration. On the last day, blood was collected from all mice by heart puncture, and the liver was dissected and separated. After the blood was centrifuged at 3000rpm, the serum was collected. The lobe of the liver was submerged in ...

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