Connection and container systems

Abstract

A first connection configuration (3A') for providing a fluid connection (2) between containers (B1, B2, B3), wherein the first connection configuration (3A') preferably includes a rigid closure device (23), which in an initial state is sealingly retained on a retaining portion (25) of the connection configuration (3A, 3A') by a fragile line (24), and the fragile line (24) preferably forms an opening area (4A') or a part thereof, whereby the retaining portion (25) can move by deforming relative to the closure device (23), whereby the first connection configuration (3A, 3A') can be opened by tearing the fragile line (24).

Description

[0001] This application is a divisional application of the invention patent application with application date of June 14, 2016, application number: 201680047576.0, and invention name: "Connection and container system". Technical Field

[0002] The present invention generally relates to the provision of fluid connections. In particular, the present invention relates to a connection system, method, container system and use for providing a fluid connection, preferably a fluid connection between containers. In addition, the present invention relates to a connection arrangement, a connection system, a container, a container system, use and a method. Background Art

[0003] In the medical field, it is often necessary to transfer a substance from one container to another container. For example, a mixture of drugs or substances is produced in the mixing bottle by first transferring the contents of one container to a mixing bottle and then transferring the contents of a second container to the mixing bottle, then sealing the mixing bottle, and producing a mixture by stirring.

[0004] In some cases (which are also the focus of the present invention), substances stored in different containers must be mixed under sterile conditions or to prevent the entry of foreign substances. Therefore, the present invention also particularly relates to the provision of sterile fluid connections or connections that prevent the entry of foreign substances such as germs.

[0005] In this section, for example, WO 2013 / 104550 A discloses a kit for producing a combination vaccine, wherein two bottles each have a septum and the kit comprises a double needle for piercing the two septa and thereby providing a continuous fluid connection between the bottles. However, it has been found that providing a fluid connection by a double needle or the like results in a relatively high flow resistance, which can slow down the transfer process between bottles.

[0006] The problem addressed by the present invention is therefore to indicate a connection system, a method, a container system and a use, as well as a connection arrangement, a connection system, a container, a container system, a use and a method, by which the production of a mixture can be simplified or accelerated and / or a specific mixing ratio can be ensured. Summary of the invention

[0007] This problem is solved by a connection system according to claim 1, a method according to claim 13, a container system according to claim 14, a use according to claim 15, a connection arrangement according to claim 16, a connection system according to claim 27, a container according to claim 28, a container system according to claim 29, a use according to claim 30 or a method according to claim 31. Further advantageous features are subject matter of the dependent claims.

[0008] In a first aspect, the present invention relates to a connection system for providing a (continuous) fluid connection, preferably a (continuous) fluid connection between containers, the connection system comprising at least two connection configurations configured to provide the fluid connection, namely, a first connection configuration and a second connection configuration, wherein in an initial state, the at least two connection configurations are fluid-tight, the first connection configuration in particular comprising a film-like, brittle and / or unstable opening area, wherein the first connection configuration can be deformed outside the opening area and is configured such that the deformation causes the first connection configuration to open in the opening area.

[0009] Advantageously, during the opening by deformation, a fluid connection with a large cross section can be produced quickly.

[0010] In another aspect, which can also be implemented independently, the present invention relates to a container system having at least two containers, preferably at least two bottles, and a connection system according to the above aspects, wherein these containers respectively include at least one connection configuration of the connection system for producing a fluid connection between these containers.

[0011] In this way, a fluid connection with a reliably large enough cross section for rapid and complete mixing of the container contents can be obtained.

[0012] In another aspect, which can also be implemented independently, the present invention relates to a use of a container system for preparing a mixture of substances, in particular, for preparing a combination vaccine for simultaneous immunization against different diseases, wherein a first container comprises a first substance, in particular, a second vaccine for preventing a first disease, and a second container comprises a second substance, in particular, a second vaccine for preventing a second disease different from the first disease, wherein these containers are fluidically connected to each other by the connection configuration so that these substances are mixed together to form in particular the combination vaccine.

[0013] In this way, mutually incompatible substances, in particular vaccines, can be mixed together quickly and reliably before being used together and administered, thereby saving time and reducing stress.

[0014] In another aspect, which can also be implemented independently, the present invention relates to a connection configuration for producing a fluid connection between containers, hereinafter referred to as a first connection configuration, wherein the first connection configuration has a preferably rigid closing device, in particular a closing plate, which in an initial state, is sealingly held on a retaining part of the connection configuration by a weak point / line, in particular a fragile fine point / line, and the retaining part can be moved relative to the closing device by deformation, so that the first connection configuration can be opened by breaking, in particular tearing / breaking, the weak point / line.

[0015] Opening of the weak point of the closure device by deformation and tearing has the advantage that the opening procedure is particularly simple, effective and reliable due to the use of the closure device, since high tensile and / or shear stresses can be generated in the weak point / line by using the closure device to facilitate the opening procedure.

[0016] In another aspect that can also be implemented independently, the present invention relates to a connection system having a first connection configuration according to the previous aspect (which can also be implemented independently) and a second connection configuration formed in particular by a mouth-shaped part (which includes a deformation device corresponding to the retaining part), wherein these connection configurations can be sealed and inserted into each other, and when these connection configurations are rotated relative to each other, the first connection configuration can be opened to produce a fluid connection due to the deformation of the retaining part by the deformation device.

[0017] Since the holding portion corresponds to the deformation means, the holding portion can be deformed effectively so that opening in the described manner can be ensured.

[0018] In another aspect, which can also be implemented independently, the invention relates to a container, in particular a bottle, having a proposed first connection arrangement, wherein the holding portion can be moved relative to the connection arrangement by deformation, and thus the first connection arrangement can be opened by tearing the weak point / line, the container preferably comprising the connection arrangement on the side facing away from the removal opening. This leads to corresponding advantages.

[0019] In another aspect, which can also be implemented independently, the present invention relates to a container system having at least two containers: a first container, which comprises a connection configuration according to one of the aforementioned aspects; and a second container, which comprises a second connection configuration according to one of the aforementioned aspects, the connection configurations corresponding to each other. The first connection configuration comprises a splitting element, in particular a piercing and / or cutting edge, by which the second connection configuration can be opened. Alternatively or in addition, the second connection configuration comprises a deformation device by which the first connection configuration opens the first container by deforming a retaining portion. Alternatively or in addition, the connection configurations are configured to produce a fluid connection by opening each other, the first connection configuration opening the second connection configuration and the second connection configuration opening the first connection configuration to thereby produce a fluid connection.

[0020] In another aspect, which can also be implemented independently, the present invention relates to the use of a connection arrangement, a connection system, a container and / or a container system according to one of the preceding aspects, which connection arrangement, the connection system, the container and / or the container system prepares a mixture of substances, preferably a medicament, in particular a vaccine or a combination vaccine, by producing a fluid connection and mixing substances that have been stored separately. This mixing can be carried out particularly effectively and reliably in this way, because the invention can produce relatively large hydraulic cross-sections between the containers so that rapid and reliable mixing can be achieved. A particular advantage is that even viscous liquid substances, in particular vaccines, can be mixed quickly, efficiently and effectively.

[0021] In another aspect, which can also be implemented independently, the present invention relates to a method for producing a connection configuration, a connection system, a container and / or a container system according to one of the preceding aspects by injection molding a closure device, a fragile point and a retaining part in a common step (preferably starting from the closure device).

[0022] Injection molding of the connection arrangement (in which hot liquefied plastic is injected into a mold corresponding to the closure device and then forced through the mold representing the weak point) has proven to be a particularly reliable method for producing thin and therefore fragile weak points. This method can also avoid leaks in the area of ​​the fragile weak point and thus increase the production rate.

[0023] The connection system is preferably adapted for and particularly advantageous for providing a fluid connection between containers, and may alternatively or additionally be used for some other fluid connection or attachment of a container to some other apparatus, for example, or may be used completely independently of any container.

[0024] The proposed connection system preferably comprises at least two or exactly two connection configurations. These connection configurations are preferably formed to complement each other and / or correspond to each other. This has the advantage that only connection configurations that match each other can be used to produce a fluid connection. The preferred complementary and / or corresponding configuration of these connection configurations also has the advantage that these connection configurations match each other in such a way that a fluid connection can be produced.

[0025] In the initial state in each case, the connection arrangement is preferably fluid-tight. This allows the mixture to be produced as needed or on the fly, and the containers, which each include a respective connection arrangement, to be used separately or independently of each other.

[0026] It can be provided that the connection arrangements are configured to be open to one another, the continuous fluid connection being produced by the mutual opening of the connection arrangements.

[0027] Preferably, the first connection configuration is configured to open another second connection configuration. Preferably, the second connection configuration should also be configured to open the first connection configuration. This achieves mutual opening of the connection configurations.

[0028] According to another aspect of the invention, which can also be implemented independently, the proposed connection system comprises a plurality of containers, each of which comprises both one of the connection configurations and an extraction / removal opening.

[0029] According to another aspect of the invention, which can also be implemented independently, the fluid connection can be produced by deforming at least one of the connecting arrangements, preferably by destroying the opening area of ​​the connecting arrangement by deforming the connecting arrangement outside the opening area.

[0030] In particular, it is conceivable that each connection arrangement serves as, comprises or embodies a means for opening the respective other connection arrangement. These means are preferably fixed to or fixedly connected to the respective connection arrangement or are formed integrally with the respective connection arrangement. This advantageously allows the fluid connection to be produced without the use of tools (except for the connection arrangement itself) and in particular enables uncomplicated handling. Advantageously, in particular, no separate tool is required that must be moved or operated separately from the connection arrangement, for which reason the proposed connection system is uncomplicated, cheap to manufacture, and reliable and durable.

[0031] Preferably, the fluid connection and / or mechanical connection of the connection arrangement or container is permanent and / or non-releasable once it has been produced. Advantageously, this can effectively prevent mixing and / or entry of foreign matter during or even partially after the production of the fluid connection. Due to the preferred permanent and / or non-releasable fluid connection, even if sterility is required, it is not necessary to use a diaphragm or the like to produce the fluid connection. Thus, an opening that is relatively larger than a needle or has a larger cross-section than a needle can be obtained to allow faster transfer and mixing of substances.

[0032] For the purposes of the invention, a connection is non-releasable, in particular when the connection can only be opened again by damaging or destroying the structure non-manually and / or using only tools. In particular, a non-releasable connection is a connection produced using snap-fit ​​hooks. However, other solutions are also possible here.

[0033] Preferably, at least one of the connection arrangements, preferably both, (each) comprises an opening area to be opened by the other connection arrangement. Preferably, the opening area comprises or is formed using or by: a film-like portion, a weak point, a weakened area, a gradually thinning wall, a film (in particular a sealing film), a membrane, a membrane-like portion and / or other construction of a part of the connection arrangement provided by constructive or mechanical or physical measurement or configuration, which can form an opening by the action of another connection arrangement without otherwise negatively affecting the function and structure of the connection arrangement, in particular by destroying, bursting, tearing and / or disassembling the opening area. In particular, the (film-like) opening area is a mechanically weak or weakened wall portion. The opening area may be breakable, brittle and / or brittle and / or may be, may form or may include a weak point. The use of an opening area has the advantage that a passage opening with a relatively large cross section can be produced simply and quickly. This enables rapid mixing and homogeneous mixing results even when the container is at least substantially filled with liquid and / or solid matter.

[0034] One or more connection configurations are preferably designed for disposable and / or irreversible openings, in particular, designed using or by one or more opening regions. Therefore, the opening formed using or by or in the connection system is preferably non-reclosable.

[0035] For the purposes of the present invention, an opening is non-reclosable or irreversibly open, in particular it can only be reclosed using special tools and / or by replacing the defective part or adding a new part. For the purposes of the present invention, a destroyed sealing film as a preferred form of open opening area is preferably regarded as non-reclosable or irreversibly open, even if it is theoretically possible to replace and reposition the destroyed sealing film using corresponding equipment.

[0036] The proposed connection system will be explained in more detail below with reference to two connection configurations, a first connection configuration and a second connection configuration. This does not necessarily imply an opening sequence, but is mainly used to distinguish the connection configurations. Thus, in particular, the second connection configuration can be generated separately from and independently of the first connection configuration.

[0037] The connection configurations are preferably different and / or configured in different ways to be used to open another respective connection configuration. Therefore, preferably, different mechanisms are used to open different connection configurations, or design connection configurations for this purpose.

[0038] The first connection configuration preferably includes a first opening area. The second connection configuration also preferably includes an opening area, hereinafter referred to as a second opening area. This is used to distinguish the opening areas and preferably does not imply a sequence or that the second opening area can be generated without the first opening area.

[0039] The second connection configuration is preferably configured to open the first connection configuration by rupturing, splitting or destroying the first weak point. Alternatively or additionally, the first connection configuration is configured to open the second connection configuration by rupturing, splitting or destroying the second opening area. Thus, the connection configurations can be opened to each other by rupturing, splitting and / or destroying the opening area of ​​one connection configuration.

[0040] In a preferred aspect of the invention which can also be implemented independently, the second opening area of ​​the second connection arrangement can be pierced by the first connection arrangement. Preferably, the first opening area of ​​the first connection arrangement can also be pierced by the second connection arrangement.

[0041] Alternatively or additionally, the first connection configuration may be deformed by the second connection configuration, in particular, the first opening region of the first connection configuration may be opened by stretching, breaking, tearing, bursting and / or disassembling the first opening region caused by the deformation.

[0042] Preferably, in a first embodiment, the connection system is configured to first open an opening area of ​​a first connection configuration using a splitting element of the second connection configuration and then open a second opening area of ​​the second connection configuration by piercing the second opening area using the first connection configuration.

[0043] Preferably, in the second embodiment, the connection system is configured to first open the second opening area of ​​the second connection configuration by piercing the second opening area using the first connection configuration and then open the opening area of ​​the first connection configuration by deforming the first connection configuration using the second connection configuration.

[0044] The embodiments may also be combined with each other, for example, by first using a splitting element of a second connection configuration to open an opening area of ​​a first connection configuration, then by using the first connection configuration to pierce the second opening area to open a second opening area of ​​the second connection configuration, and then further by using the second connection configuration to deform the first connection configuration to open the opening area of ​​the first connection configuration using the second connection configuration.

[0045] The connecting arrangements can also pierce each other, and / or one of the connecting arrangements can pierce another connecting arrangement and the other connecting arrangement can open the connecting arrangement by a deformation process.

[0046] The first connection configuration and / or the second connection configuration preferably (each) comprises a mouth-shaped portion. The mouth-shaped portion can be formed in the shape of a neck and / or a collar and / or a ring or formed as a pipe section or the like. In particular, the mouth-shaped portion is configured to convey a fluid after opening.

[0047] The mouth-shaped part is preferably configured for producing, forming or enclosing a fluid connection. For this purpose, the mouth-shaped part can be (each) closed in the initial state. In particular, the (each) mouth-shaped part is closed by the opening area so that it can be opened preferably once and / or irreversibly and / or in a fluid-tight manner. The mouth-shaped part can have an open edge or outer edge on which the opening area is preferably fixed, configured or formed in a sealing manner.

[0048] The mouth-shaped part preferably surrounds the (respective) opening area. In particular, a part of the connection arrangement comprising the opening area is connected to the mouth-shaped part, for example, because the sealing film is sealed to the open edge of the mouth-shaped part. The opening area can (but not necessarily preferably) be positioned inside the mouth-shaped part. For the purposes of the present invention, the term "surrounding" in conjunction with the opening area preferably means that the opening area or the part of the (respective) connection arrangement forming the opening area is (in the initial state) circumferentially connected to the mouth-shaped part in a fluid-tight manner or connected to the mouth-shaped part in some other way around.

[0049] Preferably, the second connection arrangement comprises a mouth-shaped portion surrounding its opening area, and preferably, the connection arrangement is configured to also pierce this opening area. In this way, the second connection arrangement can be opened.

[0050] Preferably, the mouth-shaped part and / or splitting, perforation or piercing element of the second connection configuration is used to pierce the opening area of ​​the first connection configuration. Therefore, the mouth-shaped part or the opening area of ​​the second connection configuration can be configured as a member or tool for making the first connection configuration open.

[0051] Alternatively or additionally, the second connection configuration is configured for deforming the mouth-shaped portion of the first connection configuration such that the deformation causes the opening area of ​​the first connection configuration to be broken, burst, torn and / or detached, in particular by rotating the connection configurations relative to each other. Alternatively or additionally, the first connection configuration is configured for deforming the mouth-shaped portion of the second connection configuration such that the deformation causes the opening area of ​​the second connection configuration to be broken, in particular by rotating the connection configurations relative to each other.

[0052] In the concept described, functionally it is basically possible to use the second connection configuration to replace the first connection configuration.

[0053] Preferably, the mouth-shaped portion of one of the first connection configuration and the second connection configuration is configured to align with the mouth-shaped portion of the other of the first connection configuration and the second connection configuration, preferably so that the opening area of ​​the other of the first connection configuration and the second connection configuration can be pierced and / or the other of the first connection configuration and the second connection configuration can be opened.

[0054] In particular, the connection arrangements are therefore structures each having a mouth-shaped portion, which in each case is also closed by a closure element, in particular a sealing film, comprising an opening area. In addition, the mouth-shaped portions are formed differently and complementary, so that the mouth-shaped portion of one of the connection arrangements is able to rupture the opening area of ​​the other connection arrangement. In this way, at least one of the connection arrangements is left open.

[0055] Preferably, the connection system is constructed so that only two connection configurations need to be opened or two weak points of the connection configurations need to be broken to produce a continuous fluid connection. Therefore, preferably, a continuous fluid connection is provided for the first time by opening two connection configurations, and only opening one of the connection configurations or not opening both connection configurations results in fluid blockage or fluid interception.

[0056] In particular, for the purposes of the present invention, a continuous fluid connection means: forming a passage through which a fluid can flow. Preferably, this passage is formed by making the connecting arrangements open to each other.

[0057] Preferably, the two connecting configurations include mouth-shaped parts, which have a non-circular cross-section and can be configured within each other and are configured so that the counter-rotation of these mouth-shaped parts with respect to each other causes at least one deformation of these mouth-shaped parts so as to rupture an opening area surrounded by these deformed mouth-shaped parts or adjacent to these deformed mouth-shaped parts, in particular, at least one internal opening area or an opening area belonging to an internal mouth-shaped part.

[0058] In particular, the neck-shaped mouth-shaped parts can be configured so that by pushing them into each other and rotating them in opposite directions, in particular, preferably rotating them around a common central axis, the outside of the mouth-shaped parts arranged inside contacts the inside of the mouth-shaped parts arranged outside, so that the forces thus generated reshape or deform one or both of these mouth-shaped parts. In particular, the mouth-shaped parts can each have an elliptical cross-section and / or the mouth-shaped parts can be pushed into each other in a similar orientation at least in the initial stage to cause (mutual) deformation or reshaping when rotation occurs. In this way, the longitudinal dimension can be compressed and / or the transverse dimension can be expanded, thereby causing the opening member, preferably at least the inner connecting configuration, to stretch, break, burst, tear and / or disassemble to cause opening.

[0059] Preferably, the opening area is configured to be bent, pulled and / or stretched due to deformation. In particular, the opening area is formed as a film or sealing film, which is configured to tear when the opening area is configured or the mouth-shaped portion provided thereon is deformed, thereby opening the connection configuration.

[0060] According to another aspect of the invention, a continuous fluid connection is created by orienting the first connection configuration and the second connection configuration toward each other, in particular by first rupturing only one of the first opening area and the second opening area by piercing, and by breaking the other of the first opening area and the second opening area only when the connection configurations are brought closer together.

[0061] Preferably, there are at least two different possible ways to break through the opening regions or weak points of the different connection arrangements and thereby achieve mutual opening of the connection arrangements.

[0062] In a first variant, the connection configuration is first pushed into another connection configuration and its mouth-shaped portion to thereby break through the opening area of ​​the other connection configuration, and then the deformation of the pushed connection configuration is implemented by rotating the connection configurations in opposite directions to cause the opening area of ​​the connection configuration to break and thereby produce a continuous fluid connection.

[0063] In a second variant, the connection arrangement comprises a splitting element with which the opening area of ​​the other connection arrangement is first broken and thus the opening is carried out. Only then is the mouth-shaped part of the other connection arrangement, whose opening area has been opened by the splitting element, pushed into the mouth-shaped part of the connection arrangement to thereby cause the opening area of ​​the connection arrangement to break. Thus, a continuous fluid connection is also formed by mutual opening.

[0064] The common point of the two variants is that the mouth-shaped part of a connection configuration (hereinafter often referred to as the first connection configuration) is used to break through the opening area or open the opening area of ​​another connection configuration (hereinafter often referred to as the second connection configuration), preferably by pushing it into the mouth-shaped part of this other connection configuration.

[0065] According to another aspect of the invention, which can also be implemented independently, the connection arrangements can be connected to each other, preferably non-releasably and / or by latching. Preferably, the non-releasable connection of the connection arrangements is formed even before at least one of the first and second connection arrangements is opened. In particular, the connection arrangements are configured such that a non-releasable connection must first be formed between the connection arrangements before a continuous fluid connection can be produced.

[0066] Preferably, the connection arrangement has connection positions, in particular latching positions or locking stages, which are different from one another. The connection arrangement is preferably configured to not open the first connection arrangement and the second connection arrangement or to open only one of the first connection arrangement and the second connection arrangement when reaching the first connection position and to provide a continuous fluid connection and / or opening of the two connection arrangements when reaching the other second connection position.

[0067] Thus, when the connection arrangements are pushed into each other or made to fit into each other, there can be at least two connection positions which are assumed to be one after the other. At the connection position which is reached first in time and / or distance, an unreleasable connection is produced between the connection arrangements, and a continuous fluid connection is only produced at the second connection position. This advantageously prevents the connection arrangements from being separated from each other again after one or both of the connection arrangements have been opened. In this way, leakage and / or contamination can be prevented.

[0068] Since a fluid connection is formed, the connection system is preferably self-sealing.

[0069] Therefore, preferably, the proposed connection system is used to form a fluid connection, in particular to provide a fluid passage that is isolated from the environment.

[0070] As a result of or after the formation of the fluid connection, at least the opening area preferably acts as a seal to form a seal. In particular, it can be provided that the second connection configuration comprises an opening area which, when the mouth-shaped part of the first connection configuration has been used to pierce the opening area, acts at least at the edge as a seal, a sealing lip or the like. However, alternatively or additionally, another seal, in particular a sealing ring or a sealing lip, can be provided.

[0071] In another aspect, which can therefore be implemented independently, the invention relates to a container system having containers, in particular bottles, each of which has a removal opening, in particular a diaphragm, and which are further configured to provide a fluid connection independently of the removal openings. For this purpose, a connection arrangement is provided, in particular, preferably on the side away from the removal opening. For the fluid connection of the container, in addition to the removal opening or removal device (such as a diaphragm, a rotating closure or some other preferably releasable closure), it has proven to be particularly advantageous to provide a connection arrangement also at another position, in particular, in the case of a bottle, on the end opposite to the neck of the bottle. This can produce a continuous fluid connection using the proposed connection system without affecting the function of the removal opening. In this case, the containers are advantageously kept suitable for individual and separate use with each other.

[0072] In another aspect, which can therefore be implemented independently, the invention relates to a container system with the proposed connection system, wherein a first container comprises a first connection configuration of the proposed connection system and a second container comprises a second connection configuration of the proposed connection system. Preferably, at least one of the containers comprises a removal opening and comprises a connection configuration of the proposed connection system at one end remote from or opposite to the removal opening. In this way, the containers can be fluidically connected by the proposed connection system in particular for mixing substances, without blocking and otherwise affecting (e.g. standardizing) the removal opening.

[0073] The first container and the second container preferably each comprise a removal opening and at one end remote from or opposite to the removal opening, in particular, comprise one of the proposed connection arrangements on the respective base of the bottle. Thus, the containers can be fluidically connected to each other at the end remote from the removal opening by the proposed connection system.

[0074] By forming a fluid connection, preferably a new combined container is obtained which has a combined capacity which adds up to the capacity of two containers and / or has a total of two removal openings. This has the advantage that in principle, the containers can also be used separately from each other with their own removal openings, but the contents of the containers can also be combined and mixed together by using the proposed connection system to form a continuous fluid connection between the containers.

[0075] The container system may also include at least one container, which includes a first connection configuration at a first end and another second connection configuration at a second other end, in particular, an opposite end. The two connection configurations are respectively configured to form a fluid connection. The container may have, form and / or enclose a volume in which a substance is preferably configured or configurable. This can advantageously fluidly join two or more containers together or mix two or more different substances. For this purpose, the container includes the two connection configurations so that another container can be fluidly connected at both ends by the proposed connection system. This container preferably forms an adapter between other containers of the container system, but can also be used only with another container to provide a fluid connection between them and / or can also be produced separately and / or form an independent aspect of the present invention.

[0076] In another aspect, which can therefore be implemented independently, the present invention relates to the use of the proposed container system, wherein a first container comprises a first substance, in particular, a second vaccine for preventing a first disease, and wherein a second container comprises a second substance, in particular, a second vaccine for preventing a second disease different from the first disease, wherein these containers respectively comprise removal openings and, in addition to the respective removal openings, also comprise a connection configuration for providing a fluid connection between these containers to prepare a mixture of substances, in particular to prepare a combination vaccine for simultaneous immunization against different diseases, wherein these containers are fluidically connected to each other by means of these connection configurations so that these substances are mixed together and in particular form the combination vaccine.

[0077] Preferably, the proposed container system is used for the combined administration of drugs. In particular, vaccines that are unstable together for a long time can be stored in separate containers and these containers can be fluidly connected by the proposed connection system before use, so that a mixture can be quickly and efficiently formed without affecting the removal opening such as a septum. Alternatively, if the fluid connection is not formed by the connection system, the respective vaccines can also be used separately from each other through the removal opening.

[0078] For the purposes of the present invention, the container or bottle and / or the connecting arrangement is preferably at least substantially dimensionally stable, rigid or semi-rigid and / or is at least substantially formed from a plastic material or a plastic material including in particular polyethylene, HD-PE, LD-PE or polypropylene.

[0079] For the purposes of the present invention, a "bottle" is preferably a closable container for transporting and storing fluids, in particular liquids, gases and injectable solids (such as powders). For the purposes of the present invention, a bottle preferably has a diameter that is smaller than its height. For the purposes of the present invention, a bottle preferably has a tapered end that is at least substantially conical, also referred to as the neck of the bottle. The neck of the bottle preferably ends with an opening that is, in particular, circular, closable and openable to remove its contents (also referred to as the removal opening). For the purposes of the present invention, a bottle is preferably a flask and / or a vial. In a flask, the diameter or the inner width of the removal opening is smaller than the average inner diameter of the storage space formed by the bottle, preferably smaller than 70% of the average inner diameter, in particular smaller than 50% of the average inner diameter. However, other solutions are also feasible here.

[0080] For the purposes of the present invention, a "connection arrangement" is preferably a device, which is configured to provide a fluid connection and preferably a mechanical connection when the fluid connection is formed. In particular, it is a fluid coupling, a flange, a coupling component, an attachment component, a plug connection, a male and / or female connector (in particular, a plug connector) or a part thereof.

[0081] For the purposes of the present invention, a "connection arrangement" may be a portion / region of a container, in particular a bottle, or the connection arrangement(s) are connected to a container, in particular by material, friction and / or interlocking connection. Preferably, the connection arrangement is at least partially formed by or integral with the container or bottle. Alternatively or additionally, the connection arrangement adjoins the container or bottle or is otherwise suitable for fluid attachment or connection to the interior of the container or bottle.

[0082] For the purposes of the present invention, a connection arrangement is preferably "fluid-tight" when a fluid, in particular a liquid, is prevented from leaking or passing through or when a fluid or a liquid barrier prevents a fluid, in particular a liquid, from leaking or passing through.

[0083] For the purposes of the present invention, connection arrangements are "insertable into one another", in particular when a portion of one of the connection arrangements can be arranged in the other connection arrangement or a portion thereof. In particular, at least a portion of one of the connection arrangements can be pushed, placed, inserted or introduced in another way into the other or corresponding connection arrangement. In particular, connection arrangements are inserted into one another when the connection arrangements at least partially, substantially or completely radially overlap with respect to a (common) axis of symmetry and / or a central axis or an inner portion of a connection arrangement is (radially) (completely) surrounded or encircled by an outer portion of another connection arrangement.

[0084] For purposes of the present invention, "axial movement" along a common axis is preferably non-helical, non-rotational, at least substantially or completely linear and / or completely axial movement and / or movement that does not require a complete rotation or revolution. The connection arrangements are preferably adapted to mate with each other, to be inserted into each other, and / or to fit together in at least a substantially linear manner to produce a non-releasable and / or fluid connection.

[0085] For the purposes of the present invention, "opening" means in particular: providing access to the interior of a container or bottle or to the volume contained by a container or bottle by in particular forming an opening, an orifice, a passage, a hole or the like, so that a fluid, in particular a liquid, can enter and / or leave.

[0086] For the purposes of the present invention, an "opening region" refers in particular to a region that is configured to be open, i.e. constructed so as to form an opening, an orifice, a passage, a hole or the like or to allow fluid access to the interior of the container or the volume contained by the container. The opening region is preferably fluid-closed and fluid-openable. It can be a closed hole, a closed and openable wall opening, a closed and openable passage, a closed and openable closure or the like.

[0087] A "film-like opening area" is preferably a part of an opening which has a thin wall or a flat construction, in particular. A film-like opening area is preferably an opening / area which is sealed or closed by a film-like, membrane-like, flat, thin, breakable and / or fragile structure.

[0088] In the context of the present invention, "pierceable" refers in particular to a structure that can be broken or perforated by an object, in particular a pointed end, so that a connection from a (flat) side to an opposite side can be formed. The piercing preferably produces an opening. In particular, the pierceable opening area is destroyed upon piercing and is thereby permanently opened.

[0089] In the context of the present invention, “sealed” means in particular that leakage and / or ingress of substances is prevented by a barrier.

[0090] For the purposes of the present invention, “self-sealing” means in particular that the sealing effect is produced without separate assistance using inherent means and / or automatically, fully automatically, coincidentally or without any separate steps.

[0091] For the purposes of the present invention, "sterile self-sealing" means in particular self-sealing, whereby a barrier against the ingress of germs such as bacteria or viruses is formed so as to at least substantially prevent the ingress of germs and / or leakage. In particular, the seal, the sealing gap and / or the contact pressure are designed so that any leak that could potentially remain has a maximum cross-section that prevents the passage of germs such as bacteria or viruses.

[0092] In the context of the present invention, "fluid-tight" refers in particular to a seal which at least substantially prevents the ingress or egress of fluids, in particular liquids.

[0093] In the context of the present invention, "gas-tight" refers in particular to a seal which at least substantially prevents the ingress or egress of gases.

[0094] In the context of the present invention, a "material architecture" means, in particular, a composition and / or a structure and / or a morphology and / or an arrangement of different structures, different materials or the like.

[0095] For the purposes of the present invention, a "laminated construction" (also referred to as a sandwich construction, a multilayer construction (in particular, a composite construction), a composite material and / or a laminated compound) refers in particular to a structure comprising different layers, which are preferably joined together and / or adjacent to each other, can be logically subdivided or delimited from each other, are configured so that their flat sides face each other or turn away from each other, and these flat sides include flat elements or parts that can be distinguished by their physical or chemical properties.

[0096] "At the edge" for the purposes of the present invention or "edge portion" for the purposes of the present invention refers in particular to an area which is spaced apart from the center, midpoint or center of gravity or has an edge, margin, end or border, is adjacent to an edge, margin, end or border or faces an edge, margin, end or border. In particular, it is a portion at the circumferential edge of a relatively flat structure, in particular a portion having a surrounding or annular shape or the like.

[0097] For the purposes of the present invention, "central portion" refers in particular to a portion which is spaced apart from an end, edge and / or margin and / or comprises a center, midpoint or centroid, covers a center, midpoint or centroid, or extends around a center, midpoint or centroid.

[0098] For the purposes of the present invention, “destroying the opening region” means in particular an irreversible change of the opening region, whereby its previous function as seal, wall, sealing element and / or closure is affected or such that the previous function is no longer performed, in particular due to machining, shaping, deformation, tearing, separation or by some other method. The opening region can be left open and / or a fluid connection can be produced thereby.

[0099] For the purposes of the present invention, "puncturing the opening area" means in particular: splitting the material of the opening area from one side to the other, in particular, opposite sides, and / or dividing the opening area and / or splitting the opening area by cutting, shearing, piercing or some other method.

[0100] In the context of the present invention, "remaining intact" especially means maintaining a previously existing function. In particular, the intact opening area has and maintains a closing function, a sealing function and / or a function of forming a barrier that prevents germs, fluids, liquids, gases or the like from entering and / or leaking.

[0101] For the purposes of the present invention, a fluid is preferably a flowable substance. In particular, the fluid is flowable so that it can be connected by a fluid. In particular, for the purposes of the present invention, a fluid is a liquid, a suspension, a flowable solid (such as a powdered or granular material) and / or a gas in liquid or gaseous form. Preferably, at least one of the substances, in particular two or at least two substances, is a liquid.

[0102] For the purposes of the present invention, a "fluid connection" is preferably an arrangement which is arranged to allow a fluid, in particular a liquid, a gas or a flowable solid, to pass through. In particular, it is a transit area, a passage or a channel.

[0103] In the context of the present invention, a "fluid passage" refers in particular to a component configured to allow a fluid, in particular a liquid, a gas or a flowable solid, to pass through it. In particular, it is a transit area, a connection or a passage which is preferably (closely) isolated from the environment or from one side of the passage on the wall forming the passage.

[0104] Preferably, for the purposes of the present invention, the opening region is "brittle", in particular, due to its composition and / or construction, it is suitable and designed to tear close to its elastic limit with no or very little plastic deformation (brittle fracture). In particular, the opening region has a tensile strength of less than 200 N / mm 2 Elastic limit and / or less than 100N / mm 2 , preferably less than 60N / mm 2 , a tensile strength and / or a quotient of an elastic limit and a tensile strength of less than 1, preferably less than 0.7 or 0.5. This can be achieved in particular by structuring and / or combining, bonding or laminating different materials. The opening area can be formed by a stack of several films, preferably the films of the stack contain aluminum or consist of aluminum or are metallic. Preferably, the opening area is at least partially metallic. Preferably, the opening area is formed using or by a composite material, preferably with a relatively flat aluminum layer or a film-like aluminum layer.

[0105] For the purposes of the present invention, an “unstable opening region” is preferably a region which is less mechanically stable than the parts surrounding it and / or which can be destroyed manually or by the application of force, in particular in the manner of a weak point.

[0106] For the purposes of the present invention, “outside the opening region” means that this is a region or a portion which is separate from the opening region but preferably directly or indirectly adjacent to the opening region, in particular such that a deformation of this region leads to a stretching of the opening region.

[0107] For the purposes of the present invention, "deformable" is preferably elastically or plastically deformable. The connection arrangement(s) or the mouth-shaped portion is preferably elastically deformable so as to cause a plastic / irreversible deformation of the opening area. However, the connection arrangement(s) or the mouth-shaped portion may also be plastically deformable.

[0108] For the purposes of the present invention, parts that "correspond to each other" are particularly considered to have similar and / or complementary constructions, cooperate with each other, are similar to each other, are similarly configured, have similar directional structures of similar shapes, and / or are configured to interact with each other to produce a function or effect.

[0109] In the context of the present invention, "rotate relative to one another" means in particular a rotational movement of one part, preferably a connection arrangement or a container or a bottle having a connection arrangement, relative to another part, preferably another connection arrangement or another container or another bottle.

[0110] For the purposes of the present invention, “rotating counter to each other” means in particular a rotational movement of two parts, preferably a connection arrangement or a container or a bottle having a connection arrangement, relative to another part, preferably another connection arrangement or another container or another bottle, which is preferably in different or opposite rotational directions.

[0111] For the purposes of the present invention, a "mouth-shaped portion" refers in particular to a portion comprising or forming an opening, an opening edge, a mouth or a neck (preferably having an opening at one end) or some other tubular portion or passage (having a radially surrounding wall terminating in the opening), which is preferably open at its ends and / or forms an opening at at least one end.

[0112] For the purposes of the present invention, the term “thin-walled” refers in particular to cross-sectionally flat or planar structures having an average wall thickness of less than 2 mm, 1.5 mm, 1 mm and / or less than 0.5 mm or 0.3 mm, preferably less than 200 μm, in particular less than 150 μm.

[0113] For the purposes of the present invention, a "closing device" is preferably part of the opening area or at least substantially forms the opening area. Here, a closing device is particularly understood to mean a flat or planar configuration or a closing plate. Thus, the closing device particularly has a material thickness that exceeds its longitudinal extent, preferably exceeds its longitudinal extent by at least 2, 3, 4 or 5 times.

[0114] The closure means is preferably formed in one piece, in particular with the weak point, in particular the thin point. The closure means may form the opening region or part thereof together with the weak point. Preferably, the weak point forms a film-like, brittle and / or unstable part of the opening region or renders the opening region film-like, brittle and / or unstable. For this purpose, the weak point is preferably brittle enough to form an opening by tearing under mechanical load.

[0115] The connection arrangement is preferably formed from a plastic, in particular a thermoplastic material, in particular by injection moulding. The opening area is preferably mainly formed by the closure means, in particular the closure means is formed over more than 70%, 80%, 90% or 95% of the area of ​​the opening area. Thus, the weak point occupies less than 10%, in particular less than 5% of the area compared to the surface area of ​​the closure means.

[0116] The longitudinal cross-section of the main dimension of the closure device may be S-shaped. The closure device may have ribs or other reinforcing elements to stiffen it. The closure device is preferably sufficiently stable or rigid that it does not deform or only deforms slightly due to the weak point. As a result, forces acting on the weak point do not deform the closure device or, in particular, deform it only slightly due to compression, thus ensuring that the weak point is easier to break or tear.

[0117] For the purposes of the present invention, a "weak point", in particular a thin point, preferably a film-like, brittle and / or unstable or fragile area or an opening area or a film-like, brittle and / or unstable or fragile part of the opening area. A weak point can be a predetermined breaking point. It is not limited to being a point, but can also be a weak line, a weak area, a predetermined breaking line and / or a predetermined breaking area.

[0118] The fragile point is preferably embodied and designed to rupture or tear by mechanical stress to form an opening. In particular, the fragile point interacts with the closure device and can be stretched relative to the closure device in such a way that the resulting tension, shear force and the like cause the fragile point to rupture. Therefore, a fragile point refers to or forms a weakened point or a part of a mechanical structure that is weaker than surrounding or adjacent areas.

[0119] Preferably, the fragile points are provided completely or partially circumferentially at or in the mouth-shaped part or the retaining part. The fragile points may be in the shape of a string of beads or a net. In particular, the fragile points form a strip connected to the closure device, in particular a strip connected to the closure device from the retaining part or the mouth-shaped part.

[0120] For the purposes of the present invention, a "chamber" is preferably a structure or volume that is or can be tightly sealed all around. However, a chamber may be substantially open, for example, by a connection arrangement or by opening a sealing arrangement or the like.

[0121] For the purposes of the present invention, "volume" or "formed volume" preferably means an area or (partial) chamber that is at least substantially or completely enclosed. Therefore, the term "volume" can be replaced by the term "chamber" or "partial chamber" as required. Moreover, there is a distinction between an inner volume and an outer volume; preferably, this is functionally intended to express that the inner volume can be reached by passing through the outer volume. Preferably, the outer volume surrounds the inner volume. However, this is not absolutely necessary, because in other embodiments the outer volume can form a front chamber to the inner volume. Preferably, the outer volume forms an externally sealed front chamber, while the inner volume is adjacent to the outer volume and isolated from the outer container, so that the outer volume isolates the inner volume from the environment.

[0122] For the purposes of the present invention, a "container blank" is preferably a tubular structure having at least two openings, which are or form removal openings for subsequent opening and / or closing or filling and / or removal. The other opening is of a temporary nature and is sealed during the production of the container, preferably by the use or incorporation of a seal of the connection arrangement. Thus, the connection arrangement can then form part of the container and enable a region of the container to be subsequently opened.

[0123] In the context of the present invention, the container stock comprises an opening for inserting or fitting the connection arrangement, which is preferably located on a side opposite to or away from the removal opening. However, other solutions are also possible. In addition, the container stock may also comprise only one opening for inserting or fitting the connection arrangement. In this case, the container obtained after assembly has only an opening in the form of an opening area of ​​the connection arrangement. The container stock preferably comprises a bottle-shaped portion with an at least substantially conical tapered portion or shoulder area that transforms into a bottle neck. The bottle neck then preferably forms or comprises a removal opening.

[0124] For the purposes of the present invention, a "sealing portion" is preferably an area that is configured and / or configured for sealing abutment. In particular, it is a sealing lip, a sealing strip or the like. The sealing portion may comprise a sealing surface that is formed by a surface area of ​​the sealing portion and that provides a direct sealing effect. In particular, the sealing effect is achieved by the sealing surfaces exerting pressure directly on each other. To this end, the sealing surfaces preferably exert tension or pressure on each other, for example in the form of a press fit or the like. The sealing surface is preferably formed by the material of the sealing portion or by a surface of the sealing portion. However, there are also other possibilities, for example, using a seal in the area of ​​the sealing portion.

[0125] For the purposes of the present invention, a "support portion" preferably interacts with an opening area or a weak point such that an opening of the opening area or a rupture or tearing of the weak point is avoided due to a hybrid mechanical support supported from below (in particular, it acts as a support or counter-support). In particular, this is therefore a device that diverts mechanical stresses away from or away from the fragile unstable area in order to prevent or prevent an accidental opening. In particular, the support portion is configured to relieve stresses from the weak point.

[0126] For the purposes of the present invention, a "fixing device" is preferably a means for preventing a movement, in particular a relative movement of the connection arrangement and / or the container, or other actuation, which would or could lead to the opening of the opening region. In particular, it is a fixing ring or the like which is used to prevent a movement, preferably an axial movement, of the connection arrangement relative to each other and which enables this movement during actuation or removal. The fixing device preferably comprises a blocking portion which, as an active part of the fixing device, is directly responsible for implementing or eliminating the blockage, in particular preventing the movement.

[0127] For the purposes of the invention, a "guiding device" is preferably a mechanism or part thereof which guides a movement of the connection arrangement relative to one another, in particular a bayonet-like movement. This preferably enables a bayonet connection to be obtained. A bayonet connection (also called a bayonet closure) is preferably a mechanical connection of two at least substantially cylindrical and / or rotationally symmetrical parts, in particular parts which are rotationally symmetrical about a central axis or axis of symmetry.

[0128] The connection is produced by pushing in and rotating the guide. The parts are inserted axially into each other and during the axial pushing in of the parts before they reach a stop, the parts rotate relative to each other to thereby produce an interlocking engagement block in the axial direction. This preferably produces a fluid connection.

[0129] To this end, the first guide means preferably comprises a slot, groove or other guide means arranged at least substantially at right angles, starting from a portion extending axially or parallel to the central axis or axis of symmetry and an adjoining portion extending at least substantially at right angles to the preceding direction. Thus, the portion following the axially extending portion preferably extends at least substantially in a plane perpendicular to the central axis or axis of symmetry. The further or second guide means and / or the guide means corresponding to the first guide means preferably corresponds to a button, a peg, a strip or other portion of the further guide means, thus in particular to a groove, a slot or the like. Overall, the guide means thus preferably forms a sliding guide.

[0130] To provide the fluid connection, the containers are preferably produced separately from one another. This enables the containers to be universally used.

[0131] The aspects of the invention mentioned above and to be described in the following detailed description can also be advantageously implemented individually and in various combinations.

[0132] Further details, advantages and characteristics of the invention will become apparent from the claims and the following description of preferred embodiments with reference to the drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0133] Figure 1 A longitudinal section through a container system with the proposed connection system and the resulting fluid connection is shown;

[0134] Figure 2 shows a longitudinal section through the proposed connection system in a first embodiment in a starting position;

[0135] Figure 3 showing a longitudinal section through the proposed connection system of a first embodiment in a first connection position;

[0136] Figure 4 showing a longitudinal section through the proposed connection system of the first embodiment in a second connection position;

[0137] Figure 5 shows a longitudinal section through the proposed connection system in a second embodiment in a starting position;

[0138] Figure 6 shows a longitudinal section through the proposed connection system in a second embodiment in a first connection position;

[0139] Figure 7 shows a longitudinal section through the proposed connection system in a second embodiment in a second connection position, wherein the connection arrangements are oriented relative to each other;

[0140] Figure 8 shows a longitudinal section through the proposed connection system in a second embodiment in a second connection position, wherein the connection arrangements are rotated relative to each other about a common axis;

[0141] Fig. 9 A schematic plan view showing a first container with a first connection configuration of the proposed connection system of a second embodiment;

[0142] Fig.10 A schematic plan view showing a second container having a second connection configuration of the proposed connection system of a second embodiment;

[0143] Fig.11 Display along from Figure 7 Section line XI-XI of is a schematic cross section through the proposed connection system in the second embodiment;

[0144] Fig.12shows a schematic cross section through the proposed connection system in a second embodiment after partial rotation of the connection arrangements relative to each other;

[0145] Fig.13 Display along from Figure 8 Section line XIII-XIII of is a schematic cross section through the proposed connection system in the second embodiment;

[0146] Fig.14 shows a schematic longitudinal section through a container with a connection arrangement according to a first embodiment on opposite sides;

[0147] Fig.15 A perspective view showing a container having a second connection configuration of the proposed connection system in the first embodiment;

[0148] Fig.16 shows a schematic longitudinal section through the proposed container system in a transport configuration with the proposed connection system according to a first embodiment;

[0149] Fig.17 shows a schematic longitudinal section through a first container with a first connection configuration having a cover in a sterile or sterilizable manner;

[0150] Fig.18 Display through according to Fig.17 A schematic longitudinal section of a first container with a cover device removed;

[0151] Fig.19 Show through like feet keep according to Fig.17 A schematic longitudinal section of a first container in a cover device;

[0152] Fig. 20 shows a schematic longitudinal section through a second container with the closure partly removed;

[0153] Fig.21 shows a schematic longitudinal section through the proposed container system indicating the direction of movement for providing a fluid connection to the proposed connection system;

[0154] Fig. 22 shows a schematic longitudinal section through a container system according to a further embodiment in a connected state;

[0155] Fig.23 Show the basis for passing through the initial state Fig. 22 A schematic longitudinal section of a container of a container system;

[0156] Fig.24 Show through from Fig.23 an enlarged detail of a schematic longitudinal section of a container;

[0157] Fig.25 Display through according to Fig.23 A schematic longitudinal section of a container of , wherein the cover device has been removed;

[0158] Fig.26 Display basis Fig.23 A perspective view of a container focusing on the connection configuration of the container;

[0159] Fig. 27 Show the basis for passing through the initial state Fig. 22 A schematic longitudinal section of another container of the container system;

[0160] Fig.28 Show through from Fig. 27 an enlarged detail of a schematic longitudinal section of a container;

[0161] Fig.29 Display through according to Fig. 27 A schematic longitudinal section of a container of , wherein the cover device has been removed;

[0162] Fig.30 Display basis Fig. 27 A perspective view of a container focusing on the connection configuration of the container;

[0163] Fig.31 Show the basis for passing through the initial state Fig. 22 A schematic longitudinal section of a container system;

[0164] Fig.32 Display through the first connection position according to Fig. 22 Detail of a schematic longitudinal section of a container system;

[0165] Fig.33 Display through the second connection location according to Fig. 22 Detail of a schematic longitudinal section of a container system;

[0166] Fig.34 Display through the third connection position according to Fig. 22 Detail of a schematic longitudinal section of a container system;

[0167] Fig.35 shows a schematic longitudinal section through a container system with the proposed fixing device in an initial position;

[0168] Fig.36 Display through according to Fig.35 Detail of a schematic longitudinal section of a container system of wherein the fixing device has been actuated;

[0169] Fig.37 Display the basis in the connection position through Fig.35Detail of a schematic longitudinal section of a container system;

[0170] Fig.38 Display the initial position from the basis Fig.35 A perspective view of a fixing device of an embodiment of the present invention;

[0171] Fig.39 shows a schematic longitudinal section through a container system with the proposed fixing device according to a second embodiment in an initial position;

[0172] Fig.40 Display through according to Fig.39 Detail of a schematic longitudinal section of a container system of wherein the fixing device has been actuated;

[0173] Fig.41 Display the basis in the connection position through Fig.39 Details of a schematic longitudinal section of the container system; and

[0174] Fig.42 Display the initial position from the basis Fig.39 A perspective view of an embodiment of a fixing device. DETAILED DESCRIPTION

[0175] In the following description of the preferred embodiments with reference to the drawings, the same or corresponding element symbols (with or without single quotes) have been used for the same or similar components or parts, wherein similar or same advantages or characteristics can be achieved even if the associated description is not repeated.

[0176] Figure 1 A schematic cross-section of the proposed container system B is shown with one of the first container B1 and the second container B2.

[0177] The container system B preferably comprises the proposed connection system 1. The connection system 1 is preferably configured to produce a fluid connection 2, preferably between a first container B1 and a second container B2 of the container system B.

[0178] The connection system 1 preferably comprises several connection arrangements 3A, 3B, in particular a first connection arrangement 3A associated with a first container B1 of the container system B and / or a second connection arrangement 3B associated with a second container B2 of the container system B. Preferably, the first container B1 comprises the first connection arrangement 3A and the second container B2 comprises the second connection arrangement 3B, or vice versa.

[0179] Container B1, B2 is preferably used for storing material S1, S2, in particular, for storing the first fluid and the second fluid and / or different vaccines. In particular, container B1, B2 is completely or partially filled with one or more different materials S1, S2 or vaccines. Alternatively or in addition, one or two containers B1, B2 can also store and / or store other materials S1, S2, preferably solids. Only one material S1, S2 can be a fluid, in particular, a liquid. Fluid material S1, S2 can be configured to form a solution or suspension with another material S1, S2.

[0180] The proposed container system B is preferably used for preparing drugs, in particular, combination drugs, combination vaccines or the like. However, the proposed container system B has other feasible and advantageous applications.

[0181] Preferably, the first container B1 comprises a removal opening E1 and / or the second container B2 comprises a removal opening E2. Preferably, two or at least two containers B1 , B2 of the proposed container system B comprise a removal opening E1 , E2, respectively.

[0182] In the context of the present invention, the removal openings E1 , E2 are preferably configured to dispense or remove the contents of the respective container B1 , B2 .

[0183] At least one and preferably several or all of the removal openings E1, E2 are preferably reusable, can be utilized several times, are resealable, can be reused, and / or comprise a closure element V1, V2 which preferably allows opening and closing for the purpose of gradual removal. This can be achieved by a membrane.

[0184] Preferably, the removal opening E1 , E2 is closed or closable and / or is the primary means for removing the substance S1 , S2 from the container B1 , B2 .

[0185] In the embodiment shown, at least one of the removal openings E1, E2, in particular both removal openings E1, E2, are preferably closed by a so-called septum. A septum is a device having a rubber-like closing element V1, V2, in particular a rubber stopper or an injection stopper, which is suitable for being pierced by an injection needle to remove its contents, after which the septum automatically closes the (respective) removal opening E1, E2 by means of its resilience after the injection needle is removed. The septum (also referred to as a piercing membrane) preferably has a thin area, in particular in the center, which is suitable for being pierced to draw up injection liquid using an injection needle. The injection stopper or septum is preferably fixed to the neck or removal opening E1, E2 of the bottle by means of a flange cap, preferably made of aluminum.

[0186] Preferably, one, two or all containers B1, B2(s) are injection ampoules or vials, in particular for vaccinating a plurality of animals with one dose of vaccine each, for example so-called multi-dose containers.

[0187] In this manner, substances S1, S2 in the form of powdered medicines, solutions or suspensions or vaccines in containers B1, B2 can be transferred.

[0188] The containers B1, B2 may (each) have a capacity (each connected or after connection) of greater than 10 ml (preferably greater than 50 ml, 100 ml or 200 ml) and / or less than 2 liters (preferably less than 1.5 liters or 1 liter, in particular less than 750 ml).

[0189] like Figure 1 , the closure elements V1, V2 are preferably sealingly connected to the respective removal openings E1, E2, preferably, in particular by means of a pressure ring or compression ring or flange cap which is pressed onto the respective removal openings E1, E2. However, other solutions are also possible here, such as adhesive bonding, welding, connections produced by injection molding or the like.

[0190] It is of course preferred that the containers B1 , B2 of the proposed container system B should each have a removal opening E1 , E2 , but not all containers B1 , B2 of the container system B necessarily have a removal opening E1 , E2 .

[0191] Advantageously, the use of removal openings E1, E2 on several containers B1, B2 allows the use of the respective substances S1, S2 from the respective containers B1, B2, independently of whether the connection system 1 is used. Thus, advantageously, the container system B allows the use of the two containers B1, B2 individually and also allows the use of the containers B1, B2 with the fluid connection 2 provided by the connection system 1.

[0192] The containers B1, B2 are preferably fluidically connectable to each other such that a fluid connection 2 between the volumes formed or held by the containers B1, B2 results in the containers B1, B2 connected by the connection system 1 forming a joined interior. In particular, the joined interior is characterized in that the continuous fluid connection 2 has a hydraulic cross section greater than 2 square millimeters, preferably greater than 5 square millimeters or 10 square millimeters, in particular greater than 1 square centimeter, 2 square centimeters or 3 square centimeters, or that there is no constriction between the containers B1, B2 once the fluid connection 2 has been formed (which drops below this hydraulic cross section or wherein the fluid connection 2 has at least this hydraulic cross section).

[0193] One or both containers B1, B2 are preferably configured as bottles. Preferably, the container B1, B2 (each) comprises a bottleneck F1, F2 forming or adjacent to the removal opening E1, E2. A bottleneck F1, F2 can enlarge the (hydraulic) cross section starting from a terminal edge or mouth of the removal opening E1, E2 by more than 1.5 times, in particular by more than 2 times or 2.5 times. However, the removal opening E1, E2 can also be constructed in different ways.

[0194] The container B1, B2 preferably comprises removal openings E1, E2 and connection arrangements 3A, 3B at different, opposite, diametrically opposite sides, ends, axial ends, and / or comprises removal openings E1, E2 in the neck region on the one hand and connection arrangements 3A, 3B in the base region on the other hand. In particular, the removal openings E1, E2 are formed by the bottlenecks F1, F2 and the connection arrangements 3A, 3B are provided in the base region or at the ends relative to the bottlenecks F1, F2. This has proven to be advantageous because it ensures that when the connection arrangements 3A, 3B are used, the removal openings E1, E2 remain accessible and their function is not affected.

[0195] The connection arrangements 3A, 3B are preferably not intended for removal, but rather intended for providing a durable fluid connection 2 once or irreversibly, or are non-reclosable.

[0196] The invention is explained by the preferred connection use to containers B1, B2, in particular bottles. However, the proposed connection system 1 can also be advantageously used in other areas, for example, for connecting the containers B1, B2 fluidically to other systems for example to quickly remove substances S1, S2.

[0197] Figure 2 A longitudinal section through the proposed connection system 1 according to a first embodiment is shown in a starting position or unconnected state.

[0198] Figure 3 The longitudinal section of the proposed connection system 1 according to the first embodiment is shown in a first connection position, wherein preferably no fluid connection is formed, but one of the opening areas 4A, 4B has been left open.

[0199] Figure 4 The longitudinal section of the connection system 1 according to one of the first embodiments is shown in the second connection position, in which the fluid connection 2 has been established. Figure 1 The middle position.

[0200] The proposed connection system 1 preferably comprises a plurality of connection configurations 3A, 3B (preferably at least a first connection configuration 3A and a second connection configuration 3B), which are preferably configured to at least partially complement each other or correspond to each other.

[0201] The first connection configuration 3A preferably comprises an opening area 4 A. The second connection configuration 3B preferably comprises an opening area 4B.

[0202] Preferably, the container B1 , B2 comprises an opening area 4A, 4B or the opening area 4A, 4B forms part of a respective connection arrangement 3A, 3B which is associated with or forms part of the respective container B1 , B2.

[0203] Preferably, one or both opening regions 4A, 4B are regions or parts of the respective connection arrangement 3A, 3B, which are configured to (durably and / or irreversibly) produce the fluid connection 2, in particular by (irreversibly) destroying the opening region 4A, 4B. To this end, one or both opening regions 4A, 4B may have a (mechanically) weakened region or weak point or may be configured as a weakened region or weak point. The opening regions 4A, 4B may have the same, similar or different constructions, in particular with regard to the reduced material and / or reduced shape of the opening regions 4A, 4B.

[0204] In particular, the opening regions 4A, 4B are configured to be (mechanically) destroyed or pierced to provide the fluid connection 2. To this end, the opening regions 4A, 4B according to the invention can be configured to be destroyed, perforated and / or torn under mechanical load to achieve or produce the fluid connection 2.

[0205] In the embodiment shown, the opening regions 4A, 4B are formed by film-like or membrane-like wall portions of the respective connection arrangement 3A, 3B. In particular, one or more of the opening regions 4A, 4B is a sealing film. In principle, however, the opening regions 4A, 4B can be formed by weakening the material forming the respective connection arrangement 3A, 3B and / or can be formed integrally with the respective connection arrangement 3A, 3B.

[0206] The opening regions 4A, 4B are preferably configured as wall parts of the (respective) connecting arrangement 3A, 3B. The opening regions 4A, 4B are preferably regions of low wall thickness which have been weakened to some extent compared to adjacent regions. Preferably, the opening regions 4A, 4B have a material thickness which is less than the material thickness of adjacent regions, in particular the walls, of the (respective) connecting arrangement 3A, 3B. Thus, the (respective) opening regions 4A, 4B are preferably thinner, more film-like and / or membrane-like than adjacent regions.

[0207] One or both opening areas 4A, 4B preferably comprise one or more weak points, in particular, indentations, thin areas, brittle areas or portions. In particular, the second connection arrangement 3B or its opening area 4B comprises a weak point corresponding to the mouth-shaped portion 5A of the first connection arrangement 3A. Even if the splitting force acting on the opening area 4B acts or is dispersed over a larger area by using the mouth-shaped portion 5A for this purpose, this helps or facilitates the destruction or piercing of the opening area 4B of the second connection arrangement 3B.

[0208] exist Figures 2 to 5 In the embodiment shown, the opening areas 4A, 4B are each formed by a sealing film that is tightly connected to the respective connecting configurations 3A, 3B, preferably the mouth-shaped parts 5A, 5B of the respective connecting configurations 3A, 3B, by welding, adhesive bonding, sealing or in some other manner, in particular, in a waterproof manner.

[0209] Preferably, the opening regions 4A, 4B are formed of a multilayer or laminated material, in particular a plastic / metal film composite or sandwich material. However, the opening regions 4A, 4B may also be embodied in a different manner (e.g., by using several layers and / or brittle or porous materials) so as to have only limited elasticity, so that even when subjected to only slight mechanical stresses, the opening regions 4A, 4B may still be torn or otherwise destroyed.

[0210] One or both opening regions 4A, 4B are preferably configured to tear when subjected to mechanical stress and thereby create a fluid connection 2. Preferably, the opening regions 4A, 4B have a material having a mechanical strength greater than 2000 N / mm 2 , preferably greater than 4000N / mm 2 , in particular, greater than 6000N / mm 2 Alternatively or in addition, the opening regions 4A, 4B may have an elastic modulus of less than 100 N / mm 2 , preferably less than 80N / mm 2 , more particularly, less than 60 N / mm 2 The elastic modulus and tensile strength can be determined according to EN ISO 6892-1, ISO 6892, ASTM E 8, ASTM E 21, DIN 50154, DIN 50125 and / or ISO 527, ASTM D 638.

[0211] Furthermore, preferably, one or several opening regions should have a material thickness of less than 100 μm (preferably less than 70 μm, in particular less than 50 μm) and / or greater than 5 μm (in particular greater than 10 μm).

[0212] The first connection arrangement 3A, 3A' preferably comprises a first, in particular film-like, opening area 4A, 4A' and / or the second connection arrangement 3B, 3B' preferably comprises a second, in particular film-like, opening area 4B, 4B'. Advantageously, this simultaneously ensures a fixed closure 14 of the respective connection arrangement 3A, 3A', 3B, 3B' and a reliable and simple opening of the respective opening area 4A, 4A', 4B, 4B'.

[0213] The first connection arrangement 3A, 3A' is preferably configured to open the second connection arrangement 3B, 3B' by piercing or destroying the second opening area 4B, 4B'. Alternatively or in addition, the second connection arrangement 3B, 3B' is preferably configured to open the first connection arrangement 3A, 3A' by piercing or destroying the first opening area 4A, 4A'. Thus, the fluid connection 2 can advantageously be produced manually or without the use of tools. Preferably, the interior of the containers B1, B2, B3 can be connected by the connection arrangement 3A, 3A', 3B, 3B' without any additional help or tools.

[0214] Preferably, to produce the fluid connection 2, the first connection configuration 3A, 3A' can be used to pierce the second opening area 4B, 4B' of the second connection configuration 3B, 3B' and preferably the second connection configuration 3B, 3B', in particular the splitting element 7 of the second connection configuration 3B, 3B', can be used to pierce the first opening area 4A, 4A' of the first connection configuration 3A, 3A'. Thus, the fluid connection 2 can be produced by mutual perforation or piercing.

[0215] The connection configurations 3A, 3A', 3B, 3B' preferably have mouth-shaped portions 5A, 5A', 5B, 5B', which are formed so that the mouth-shaped portions 5A, 5A', 5B, 5B' of one of the first connection configuration 3A, 3A' and the second connection configuration 3B, 3B' can be aligned with the mouth-shaped portions 5A, 5A', 5B, 5B' of the other of the first connection configuration 3A, 3A' and the second connection configuration 3B, 3B', so that preferably, the opening area 4A, 4A', 4B, 4B' of the other of the first connection configuration 3A, 3A' and the second connection configuration 3B, 3B' can be pierced and / or the other of the first connection configuration 3A, 3A' and the second connection configuration 3B, 3B' can be opened.

[0216] The opening area 4A preferably comprises a mouth-shaped portion 5A and / or the opening area 4B comprises a mouth-shaped portion 5B. The mouth-shaped portions 5A, 5B preferably delimit the opening areas 4A, 4B. The mouth-shaped portions 5A, 5B may be formed integrally with the respective connection configurations 4A, 4B and / or may be formed as wall portions of the respective connection configurations 4A, 4B. Preferably, the mouth-shaped portions 5A, 5B have an open edge or are formed in the shape of a collar or a neck, and the respective opening areas 4A, 4B are preferably surrounded or delimited by the respective mouth-shaped portions 5A, 5B. The mouth-shaped portions 5A, 5B or their open edges preferably abut the opening areas 4A, 4B or delimit the opening areas 4A, 4B, or vice versa. Preferably, the open edges of the respective mouth-shaped portions 5A, 5B form a (circumferential) fixed portion of the opening areas 4A, 4B, more particularly, they are in the form of a film or are formed by a film.

[0217] In another aspect of the invention, which can also be implemented independently, the container system B comprises a cover device 6 configured to hold one of the containers B1, B2, in particular, to serve as a base for the containers B1, B2. Advantageously, the cover device 6 can alternatively or additionally be used in particular for aseptically covering one of the containers B1, B2 and / or one of the connection arrangements 3A, 3B. This aspect will be discussed in more detail below.

[0218] The connection configurations 3A, 3B and methods for creating fluid connections with the connection configurations 3A, 3B are described below. Figures 2 to 5 This is explained in more detail in the illustrated first embodiment.

[0219] In the first embodiment, the first connection arrangement 3A is configured to open the opening area 4B of the second connection arrangement 3B. Preferably, the mouth-shaped portion 5A of the first connection arrangement 3A should be suitable for being inserted or pushed into the mouth-shaped portion 5B of the connection arrangement 3B, so that during the insertion or introduction, the opening area 4B of the second connection arrangement 3B is open.

[0220] In the embodiment shown, the first connection configuration 3A, 3A' or the first mouth-shaped portion 5A, 5A' is preferably a male coupling element and / or the second connection configuration 3B, 3B' or the second mouth-shaped portion 5B, 5B' is preferably a female coupling element to form in particular a fluid coupling.

[0221] In particular, provision can be made that one end or the open edge of the mouth-shaped portion 5A has an outer circumferential edge which can be arranged within the inner circumferential edge of the mouth-shaped portion 5B.

[0222] Preferably, the outer circumferential edge of the mouth-shaped portion 5A of the first connection configuration 3A corresponds to or is similar to the inner circumferential edge of the mouth-shaped portion 5B of the second connection configuration 3B, or vice versa. In particular, the mouth-shaped portion 5A of the first connection configuration 3A includes an outer diameter at least laterally of the opening area 4A or when transitioning to the opening area 4A, which is smaller than the inner diameter of the mouth-shaped portion 5B of the second connection configuration 3B, preferably at least smaller than one of the inner diameters of the mouth-shaped portion 5B of the second connection configuration 3B at the terminal edge or when transitioning to the opening area 4B. Figures 2 to 5 In the embodiment shown, the mouth-shaped portions 5A, 5B are preferably neck-shaped and / or have an at least substantially circular cross-section.

[0223] Unless otherwise indicated, for the purposes of the present invention the term "cross section" always refers to a section or a representation of a section at right angles to the longitudinal axis or axis of symmetry 9 of the respective container B1 , B2 and / or the respective connection arrangement 3A, 3B.

[0224] The second connection arrangement 3B of the first embodiment preferably comprises a splitting element 7, which is preferably configured to pierce, split, cut or substantially destroy the opening area 4A of the first connection arrangement 3A. In particular, the splitting element 7 comprises or is formed by: a piercing device, a point, a blade, a wedge or a universal cutting and / or splitting device.

[0225] The splitting element 7 is preferably arranged and / or attached to the opening area 4B of the second connection arrangement, in particular, directly arranged and / or attached to the opening area 4B of the second connection arrangement. The splitting element 7 is preferably arranged on the outside of the second connection arrangement 3B or on the side or outside away from the interior of the container B2. The splitting element 7 is preferably arranged so that by bringing the connection arrangement 3B of the splitting element 7 close to the opening area 4A of the first connection arrangement, the splitting element 7 applies a force to the opening area 4A, which causes the opening area 4A to be destroyed and opened, preferably without opening or destroying the opening area 4B of the second connection arrangement 3B.

[0226] In particular, the splitting element 7 is a device that concentrates force on the opening area 4A or disperses the reaction force on the second connection configuration 3B or the opening area 4A, so that when the opening area 4A is opened due to being destroyed by the splitting element 7, the opening area 4B of the second connection configuration 3B remains intact.

[0227] In a variant (not shown in the figures), the splitting element 7 is arranged on the inside of the connection arrangement, in the interior of the container B1 or inside the interior of the container B1, or (seen from the outside) behind the opening area 4B of the second connection arrangement 3B. Preferably, when the mouth-shaped part 5A is pushed into the mouth-shaped part 5B of the second connection arrangement 3B, the opening area 4A, 4A' of the first connection arrangement 3A is destroyed by the splitting element 7. For this purpose, the splitting element 7 is provided in particular directly behind the opening area 4B of the second connection arrangement 3B (on the inside of the first connection arrangement 3A or on the side facing away from the first connection arrangement 3A).

[0228] Preferably, the splitting element 7 is arranged or fixed immovably on the second connection arrangement 3B, in particular (directly) on, in front of or behind the opening area 4A.

[0229] Figure 2 The proposed connection system 1 is shown in the starting position, wherein the opening area 4A, 4B or the container B1, B2 is closed or sealed. In particular, the container B1, B2 (each) is a bottle or bottle-like container B1, B2, whose bottom opening area 4A, 4B is closed in the starting position.

[0230] As shown by the arrows 8 indicating movement, the first connection arrangement 3A and the second connection arrangement 3B can be moved towards each other or pushed into each other. For this purpose, the connection arrangements 3A, 3B are preferably axially moved towards each other relative to a central axis or axis of symmetry 9. The central axis or axis of symmetry 9 is preferably the central axis or axis of symmetry 9 of the two mouth-shaped parts 5A, 5B and / or one or two opening areas 4A, 4B and / or one or two containers B1, B2.

[0231] Thus, the container B1, B2, the connection arrangement 3A, 3B, the opening area 4A, 4B and / or the mouth-shaped portion 5A, 5B can be formed substantially symmetrically with respect to the central axis or axis of symmetry 9. The mouth-shaped portion 5A, 5B is preferably axially and / or rotationally symmetrically constructed, because this enables the connection arrangement 3A, 3B to be used regardless of its rotational position. However, other solutions are also theoretically feasible, in particular, solutions in which the mouth-shaped portion 5A, 5B is non-rotationally symmetrical or non-circular and preferably provides a guide (which is configured to define the rotational position of the connection arrangement 3A, 3B relative to the central axis or axis of symmetry 9). This will be discussed in more detail in conjunction with the second embodiment.

[0232] like Figure 3As can be seen in the figure, when the connection arrangements 3A, 3B are close to each other, preferably a point 7A is used and the splitting element 7 is applied to the opening area 4A by moving the connection arrangements 3A, 3B further toward each other to push the splitting element 7 through the opening area 4A. In this way, the opening area 4A is destroyed or the connection arrangement 3A and / or the container B1 is opened.

[0233] The connection arrangements 3A, 3A', 3B, 3B' are preferably designed to be separate and / or independent of each other in the starting position (see also Fig.16 and Fig.17 ). This advantageously enables common and individual use of chambers or containers B1, B2, B3 connected to or connectable to the connection arrangements 3A, 3A', 3B, 3B'.

[0234] In the starting position, the connecting arrangements 3A, 3A', 3B, 3B' are preferably not connected to one another or are fluidly separated from one another. Due to the formation of the fluid connection 2, the connecting arrangements 3A, 3A', 3B, 3B' are moved into the connecting position in which the fluid connection 2 is formed.

[0235] Preferably, a fluid connection 2 is created between the containers B1 , B2, B3 at least when the volumes or substances S1 , S2, S3 enclosed by the containers B1 , B2, B3 can move between the containers B1 , B2, B3 by gravity and / or mix with each other.

[0236] In particular, a fluid connection 2 is a channel or a passage through which a fluid substance S1 , S2 , S3 , in particular a liquid, can flow.

[0237] The connection arrangements 3A, 3A′, 3B, 3B′ are preferably usable only once and / or can be opened irreversibly; the fluid connection 2 is preferably permanent and / or irreversible.

[0238] The connection system 1 is preferably configured for providing a non-releasable or non-detachable connection, in particular wherein the non-detachable connection occurs even before at least one of the connection arrangements 3A, 3A', 3B, 3B' has been opened. This prevents leakage of substances and advantageously prevents a part of the mixing process from occurring.

[0239] The connection arrangements 3A, 3A', 3B, 3B' preferably comprise fixing means 10A, 10B for producing a non-releasable connection, which produce a non-releasable connection between the connection arrangements 3A, 3A', 3B, 3B' by cooperating with each other and / or passing through each other by axial movement along their common axis. In particular, the fixing means 10A, 10B comprise snap-fit ​​hooks and / or are non-releasable or self-fixing by snap-fit ​​hooks or a snap-fit ​​hook connection. In this way, it can be ensured that the connection cannot be released manually and / or released without damage or destruction.

[0240] The connection arrangements 3A, 3A', 3B, 3B' can be connected to each other non-releasably or non-separably, preferably by interlocking and / or frictional engagement, in particular by latching. In particular, different connection positions, in particular latching positions, can be achieved by fitting and / or inserting into each other by axial movement along a common axis.

[0241] In particular, one of the connection arrangements 3A, 3A', 3B, 3B' comprises a locking member, in particular one or more latching lugs, arranged on the parts axially positioned behind each other. Preferably, the latching member of one of the connection arrangements is arranged so that one or more complementary latching members, in particular one or more grooves or undercuts, of the other connection arrangement 3A, 3A', 3B, 3B' latch with each other to form an engagement by using an axial movement along a common axis to fit each other and / or insert into each other. This enables a non-releasable or non-detachable connection or connection position to be achieved.

[0242] The connection configurations 3A, 3A', 3B, 3B' are preferably configured so that when the first connection position is reached, a non-releasable or non-detachable connection is formed and / or both the first connection configuration 3A, 3A' and the second connection configuration 3B, 3B' are not open or only one of the first connection configuration 3A, 3A' and the second connection configuration 3B, 3B' has been opened. Thus, preferably, the fluid connection 2 is not formed or is not fully formed in the first latched position.

[0243] When a further second connection position is reached, which position and / or time is preferably after the first connection position, a continuous fluid connection 2 and / or opening of the two connection arrangements 3A, 3A′, 3B, 3B′ is preferably produced.

[0244] A continuous fluid connection 2 is produced by preferably first destroying, in particular piercing, only one of the first opening areas 4A, 4A' and the second opening areas 4B, 4B' by bringing the first connection configuration 3A, 3A' and the second connection configuration 3B, 3B' toward each other, and only when the connection configurations 3A, 3A', 3B, 3B' are brought closer together or subsequently rotated relative to each other or pushed into each other, by destroying the other of the first opening areas 4A, 4A' and the second opening areas 4B, 4B'.

[0245] Preferably, the connection system 1 has a first connection position, in which the connection arrangements 3A, 3B are non-releasably connected to each other, preferably by latching. To this end, the connection arrangements 3A, 3B can have mutually corresponding fixing devices 10A, 10B, which produce a non-releasable connection between the connection arrangements 3A, 3B when the connection arrangements 3A, 3B are closely together.

[0246] In the embodiment shown, the fixing means 10A, 10B are formed by corresponding or complementary undercuts, latching lugs or the like. In particular, individual latching lugs are formed on one of the connection arrangements 3A, 3B and in particular, annular beads and / or undercuts are formed on the other of the connection arrangements 3A, 3B, which by co-operation provide a latching connection between the connection arrangements 3A, 3B.

[0247] Preferably, the fixing means 10A, 10B are configured for non-releasably connecting the connection arrangements 3A, 3B to each other in the first connection position, but allowing a further movement of the connection arrangements 3A, 3B towards each other.

[0248] Furthermore, the fixing device 10A, 10B is preferably configured so as to support a further second connection position, in which the connection arrangements 3A, 3B are closer together or pushed further into each other than in the first connection position. Preferably, a plurality of latching positions are provided, in which in the first latching position the connection arrangements 3A, 3B are already non-releasably connected to each other. Figure 3 The proposed connection system 1 is shown in this first connection position.

[0249] In the first connection position, one of the connection arrangements 3A, 3B may have been opened. Alternatively or additionally, the first connection position may also be characterized in that a non-releasable connection is actually formed between the connection arrangements 3A, 3B, but the opening areas 4A, 4B are not opened or are not opened.

[0250] exist Figure 3 In the embodiment shown, in the first connection position, the first connection arrangement 3A is unreleasably connected to the second connection arrangement 3B by latching and the first opening area 4A has been opened or destroyed by the splitting element 7 .

[0251] Figure 4The proposed connection system 1 is shown in a second connection position, in particular a further latching position, in which the connection arrangements 3A, 3B have been brought closer together and / or pushed further into each other than in the first connection position, in particular at least substantially completely pushed into each other. In the second connection position, the first opening area 4A of the first connection arrangement 3A has been opened by the second connection arrangement 3B and the opening area 4B of the second connection arrangement 3B has also been opened by the first connection arrangement 3A.

[0252] To open the second connection arrangement 3B using or by means of the first connection arrangement 3A, preferably the mouth-shaped portion 5A of the first connection arrangement 3A is pushed through the opening area 4B of the second connection arrangement 3B, thereby destroying the opening area 4B. This is preferably done when the connection arrangements 3A, 3B are moved from the first connection position into the second connection position.

[0253] The fixing means 10A, 10B are preferably configured to prevent the connection arrangements 3A, 3B from moving away from each other (axially) both in the first connection position and in the second connection position. Thus, in particular, it is conceivable that the connection arrangements 3A, 3B can be moved further from the first connection position into the second connection position, but cannot be moved in the opposite direction. Furthermore, preferably, in the second connection position (cf. Figure 4 ), the connection configurations 3A, 3B cannot be moved back to the first connection position.

[0254] Preferably, in the first connection position, the connection arrangements 3A, 3B abut against each other, in particular sealingly abut against each other. This prevents the substances S1, S2 from leaking out.

[0255] According to one aspect of the invention which can also be implemented independently, a seal is formed relative to the environment during or due to the opening area 4B of the second connection configuration 3B being opened by the mouth-shaped portion 5A of the first connection configuration 3A. In particular, the opening area 4B of the second connection configuration 3B forms a sealing system with the mouth-shaped portion 5B of the second connection configuration 3B. Alternatively or in addition, the mouth-shaped portions 5A, 5B can produce a sealing effect by applying pressure to each other, while the opening area 4B acts as a seal or provides a seal, in particular, at the edge and / or in the area of ​​the transition to the mouth-shaped portion 5B. However, there are also other feasible solutions, for example, the use of additional or separate rubber seals, sealing lips or the like.

[0256] Preferably, a threadless connection arrangement 3A, 3B or connection system 1 is formed. We have found that known systems from the prior art (which use threads to move the cutting tool to open the container) are more likely to be defective and require greater effort to produce an opening or fluid connection. Advantageously, the connection arrangements 3A, 3B of the connection system of the present invention can be connected to each other by simple linear or axial movement and / or by moving directly toward each other (without having to rotate several revolutions relative to each other). This has proven to be conducive to quickly and comfortably producing a fluid connection 2.

[0257] In this connection, the proposed connection system 1 also advantageously comprises one or more connection positions, preferably in the form of latching positions. This has the particular advantage over interlocking threads that a non-releasable connection can be produced between the connection arrangements 3A, 3B. On the other hand, if a threaded connection is used, there may be disassembly and contamination problems.

[0258] However, it is theoretically also possible to combine aspects of the invention with connection arrangements 3A, 3B which connect or can be connected by interlocking threads or in which the fluid connection 2 can be produced by interlocking threads and a rotational movement relative to one another.

[0259] In the following, Figures 5 to 13 A connection system 1 is shown according to one of the second embodiments. Only special features and differences from the above described embodiments will be discussed, so that the above statements also apply in a complementary manner to the second embodiment, unless expressly indicated to the contrary or obvious to the skilled person.

[0260] Figure 5 The first connection arrangement 3A' and the second connection arrangement 3B' according to the second embodiment are shown in the starting position. In the second embodiment, the two connection arrangements 3A', 3B' preferably do not have a splitting element. In particular, the connection system 1 according to the second embodiment has no cutting tool, splitting mechanism and / or sharp-edged protrusions or parts for opening.

[0261] In the second embodiment, the mouth-shaped parts 5A' and 5B' of the connection arrangement 3A', 3B' are preferably configured to be non-rotationally symmetrical or non-circular or elliptical with respect to the central axis or axis of symmetry 9. Preferably, the mouth-shaped parts 5A, 5B are configured to correspond to each other and / or have similar circumferences, so that they can be arranged inside each other and / or can be pushed into each other. Moreover, for additional information, reference can be made to the explanation of the mouth-shaped parts 5A, 5B in the first embodiment.

[0262] Figure 6 The connection arrangements 3A', 3b' are shown in a first connection position, wherein the connection arrangements 3A', 3B' are connected to each other, preferably unreleasably connected to each other. For this purpose, a fixing device 10A, 10B as explained above can be used.

[0263] The connection arrangement 3A', 3B' preferably comprises opening areas 4A', 4B' corresponding to or similar to the opening areas 4A, 4B of the first embodiment. Figure 6 In the first connection position, the opening areas 4A', 4B' are butted against each other or directly adjacent to each other. However, alternatively, in the first connection position, the opening area 4B' of the second connection arrangement 3B' can also be opened, as will be described below in conjunction with Figure 7 To explain.

[0264] To open or penetrate the second opening area 4B', the mouth-shaped part 5A' of the first connection arrangement 3A' is pressed through the opening area 4B' of the second connection arrangement 3B', as explained in conjunction with the opening of the opening area 4B of the first embodiment. Preferably, the opening area 4B' is destroyed or opened, in particular, a sealing film or a film-like part of the second connection arrangement 3B', in particular by pushing a part of the first connection arrangement 3A' through the opening area 4B' so that the opening area 4B' is opened or a film or a film-like part forming the opening area 4B' is pierced or destroyed. The results are shown in Figure 7 In which, due to reaching the second connection position, the second connection arrangement 3B' has been opened in the described manner.

[0265] In contrast to the first embodiment, the method for providing a fluid connection 2 in the second embodiment starts with the following steps: opening the second connection arrangement 3B' by the mouth-shaped part 5A' or destroying the opening area 4B' of the second connection arrangement 3B' using the mouth-shaped part 5A'.

[0266] It is also conceivable that in the second embodiment, the connection arrangements 3A', 3B' can be rotated relative to each other or around the (common) center axis or symmetry axis 9 in their connected state, in particular in the second connected position. Therefore, preferably, the other of the connection arrangements 3A', 3B', ie in particular the first connection arrangement 3A', is opened, as will be described below with reference to Figures 8 to 13 Let me explain in detail.

[0267] In one aspect, the first opening regions 4A, 4A' of the first connection configuration 3A, 3A' can preferably be opened by deformation of the second connection configuration 3B, 3B'. The opening regions 4A, 4A', 4B, 4B' can also be mutually opened by mutual deformation. The opening by deformation preferably does not require any shearing edges or splitting elements, which is beneficial to simplify the process and reduce the use of materials.

[0268] The second connection configuration 3B, 3B' is preferably configured to open the first connection configuration 3A, 3A', while the second connection configuration 3B, 3B' is preferably configured to open the opening area 4A, 4A' of the first connection configuration 3A, 3A' by deformation of the first connection configuration 3A, 3A'.

[0269] Preferably, in this respect, the deformation is induced by rotating the connection arrangements 3A, 3A' relative to each other, in particular rotating the connection arrangements 3A, 3A' about the common axis 9, and / or opening an opening region 4A, 4A' of a first connection arrangement 3A, 3A'.

[0270] The connecting arrangements 3A, 3A', 3B, 3B' preferably have mutually corresponding non-circular, in particular oval or at least substantially oval parts which can be inserted into each other and / or deformed and / or opened when rotating relative to each other.

[0271] The deformation preferably causes the opening area 4A, 4A' to be tensioned at least substantially radially or transversely to the central axis or symmetry axis 9 or along the opening area of ​​the opening area 4A, 4A' to thereby tear, rupture or disassemble the opening area 4A, 4A' and / or open the opening area 4A, 4A'.

[0272] At the same time, the second connection arrangement 3B, 3B' can in particular have a film-like, fragile and / or unstable opening area 4B, 4B', preferably wherein the first connection arrangement 3A, 3A' is configured to open the second connection arrangement 3B, 3B'. In particular, the first connection arrangement 3A, 3A' is configured to open the second connection arrangement 3B, 3B' by breaking through the opening area 4B, 4B' of the second connection arrangement 3B, 3B'.

[0273] The first connection arrangement 3A, 3A' preferably comprises a mouth-shaped portion 5A, 5A' adjacent to the opening area 4A, 4A' or surrounding the opening area 4A, 4A', the mouth-shaped portion 5A, 5A' being deformable so that the opening area 4A, 4A' can be opened by deformation.

[0274] The mouth-shaped part 5A, 5A' is preferably in the form of a net, a neck, a wall, a thin wall, or is elastic and / or flexible, and / or the mouth-shaped part 5A, 5A' is more elastic, more flexible and / or more stable than the opening area 4A, 4A'. Preferably, the opening area 4A, 4A' is opened based on the deformation of the mouth-shaped part 5A, 5A', in particular by tearing, breaking or disassembling the opening area 4A, 4A'.

[0275] The second connection arrangement 3B, 3B' is preferably configured for deforming the mouth-shaped portion of the first connection arrangement 3A, 3A' such that the deformation causes the opening area 4A, 4A' of the first connection arrangement 3A, 3A' to open.

[0276] The mouth-shaped portions 5A, 5A', 5B, 5B' preferably have a non-circular, in particular, elliptical, at least substantially elliptical and / or polygonal cross-section, while the second connection configuration 3B, 3B' has a corresponding cross-section, so that rotating the connection configurations 3A, 3A', 3B, 3B' relative to each other causes the first connection configuration 3A, 3A' to deform and / or open in its opening area 4A, 4A'.

[0277] The two connecting arrangements 3A, 3A', 3B, 3B' preferably have mouth-shaped parts 5A, 5A', 5B, 5B' which can be arranged in each other in a directional manner or pushed into each other, while the rotation of the connecting arrangements 3A, 3A', 3B, 3B' or the mouth-shaped parts 5A, 5A', 5B, 5B' relative to each other causes deformation of the first mouth-shaped part 5A, 5A' and preferably the second mouth-shaped part 5B, 5B'.

[0278] The connection arrangements 3A, 3A', 3B, 3B' can be connected to one another by a bayonet connection or they can comprise connection pieces or guides 18A, 18B which are configured to form a bayonet connection. For this purpose, the mouth-shaped parts 5A, 5A', 5B, 5B' can first be pushed into one another or can be pushed into one another (only) in the axial direction and can only thereafter be rotated relative to one another, while preferably no fluid connection 2 is formed before the mouth-shaped parts 5A, 5A', 5B, 5B' are rotated relative to one another. Thus, the guides 18A, 18B can be designed for a bayonet connection. For this purpose, a (purely) axially extending guide can be adjacent to a (purely) radial guide.

[0279] Preferably, the opening area 4A' of the first connection configuration 3A' is subjected to mechanical stress by rotating the connection configurations 3A', 3B' relative to each other when the mouth-shaped part 5A' of the first connection configuration 3A' is arranged in the mouth-shaped part 5B' of the second connection configuration 3B', in particular, the opening area 4A' of the first connection configuration 3A' is tensioned by deforming the mouth-shaped part 5A' of the first connection configuration 3A' to an extent that it tears.

[0280] To improve the understanding of the opening mechanism for opening the first opening area 4A' of the first connection arrangement 3A' from the second embodiment, Fig. 9 and Fig.10 Each shows a plan view of a connection configuration 3A', 3B'. Fig. 9 The second connection arrangement 3B' shown in FIG. 3 preferably has a mouth-shaped portion 5B' which is similar in shape and / or contour to Fig.10 , but with a larger size, diameter, longitudinal extent and / or lateral extent (at right angles to the central axis or axis of symmetry 9).

[0281] In particular, the second connection configuration 3B' comprises an inner circumferential edge 15 (formed by Fig. 9 ), which is similar to the outer circumferential edge 16 of the mouth-shaped portion 5A', corresponds to the outer circumferential edge 16 of the mouth-shaped portion 5A', and / or is configured so that the outer circumferential edge 16 can be accommodated by the inner circumferential edge 15. Preferably, the maximum diameter of the inner circumferential edge 15 is greater than the maximum diameter of the outer circumferential edge 16 and / or the minimum diameter of the inner circumferential edge 15 is greater than the minimum diameter of the outer circumferential edge 16, preferably more than 2% or 3% greater and / or less than 40% greater, preferably less than 30%, more particularly less than 20%, 15% or 10%. This enables the mouth-shaped portions 5A', 5B' to be pushed into each other only, while the opening area 4A' of the first connection arrangement 3A' is reliably open.

[0282] The mouth-shaped parts 5A', 5B' can be arranged in each other or pushed into each other preferably with play. Due to the arrangement of the mouth-shaped parts 5A', 5B', a gap 17 or a space is (at least partially) formed between the inner circumferential edge 15 and the outer circumferential edge 16.

[0283] In the embodiment shown in connection with the preferred variant, the mouth-shaped portions 5A', 5B' each have an elliptical cross section, in particular, at least substantially elliptical. However, in theory, other shapes are feasible, such as at least substantially square or other polygonal shapes. In theory, the range of the cross section in the main axial direction or the maximum range in the secondary axial direction (centrally and transverse to or perpendicular to the main axial direction) preferably exceeds the minimum range of the cross section by more than 1.2 times, preferably 1.3 times, in particular, 1.5 times, and / or at least or at least substantially 2 times. This allows the deformation of the connection configurations during rotation relative to each other to be strong enough so that the opening of the opening area 4A' of the first connection configuration 3A' occurs reliably.

[0284] Figures 11 to 13 The connection arrangements 3A', 3B' are shown in different rotational positions relative to each other, preferably in the second connection position.

[0285] Preferably, in the (non-releasable) connected state of the connection arrangements 3A', 3B' or when the mouth-shaped parts 5A', 5B' are inserted into each other, the connection arrangements 3A', 3B' can be turned or rotated by more than 45° and / or less than 200°, in particular less than 135° and / or at least substantially by 90° around the (common) center axis or axis of symmetry 9. This ensures that one or both mouth-shaped parts 5A', 5B' are deformed and / or the opening area 4A', 4B', in particular the opening area 4A' of the first connection arrangement 3A', is opened.

[0286] exist Figure 8In the embodiment shown, the mouth-shaped portions 5A', 5B' are similar, in particular, with reference to a radial circumference line of the central axis or axis of symmetry 9, in particular, so that after the first mouth-shaped portion 5A' has been inserted or pushed into the second mouth-shaped portion 5B', the first mouth-shaped portion 5A' and the second mouth-shaped portion 5B' remain loose or have a gap with each other or are at least partially directly connected to each other, in particular, at least at two points opposite to each other relative to the central axis or axis of symmetry 9 and / or at least 20%, preferably at least 50%, of their respective circumferences.

[0287] Due to the non-rotationally symmetrical or non-circular shape of the mouth-shaped parts 5A, 5B, the rotation indicated by the rotation arrow 11 leads to forces that produce a deformation effect on the first connection arrangement 3A', in particular, its mouth-shaped part 5A'. In the embodiment shown, the mouth-shaped parts 5A', 5B' have an elliptical cross section. This has proven to be particularly advantageous because it ensures that the mouth-shaped parts 5A', 5B' slide through each other without hindrance during the rotation and ensures that the mouth-shaped part 5B' of the second connection arrangement 3B' is at least substantially continuously deformed during the rotation of the connection arrangements 3A', 3B' relative to each other. However, other non-rotationally symmetrical or non-circular cross sections are also feasible, such as rectangular, polygonal, triangular or the like.

[0288] Fig.12 A schematic cross section through the connection system 1, in particular the connection system 1 in the second connection position, is shown, the mouth-shaped parts 5A', 5B' being rotated relative to each other through about 45° in one position. The respective mouth-shaped parts 5A', 5B' generate forces acting on each other in order to generate a deformation of the mouth-shaped part 5B' of the second connection configuration 3B' and preferably simultaneously generate a particularly corresponding deformation of the mouth-shaped part 5A' of the first connection configuration 3A'. As indicated by the broken line 12, the deformation of the mouth-shaped part 5B' leads to tensile and / or compressive stresses on the opening area 4B' and preferably thus leads to a break or an opening.

[0289] Fig.13 A schematic cross section through the proposed connection system 1 is shown, wherein the first connection configuration 3A' has been rotated through at least substantially 90° relative to the second connection configuration 3B'. Fig.12 Compared to the rotation shown in FIG. 4 through approximately 45°, increased rotation of the connecting arrangements 3A', 3B' relative to each other increases the tension or compressive stress and / or tensile stress on the opening area 4B', causing the opening area 4B' to tear, rupture, become detached (at the edges), or open in some other way.

[0290] The connection system 1 according to the second embodiment preferably comprises guides 18A, 18B (refer to Fig. 9 and Fig.10), which is used to connect the connection arrangement 3A', 3B' in a rotationally oriented position or for determining the rotational position during connection of the connection arrangement 3A', 3B'. In particular, a sliding guide or the like is provided, whereby the connection arrangement 4A', 4B' or the mouth-shaped parts 5A', 5B' can only be fitted, placed or pushed into each other in certain rotational positions (relative to the central axis or axis of symmetry 9), preferably so that the mouth-shaped parts 5A', 5B' are similarly oriented.

[0291] In particular when the main axes, longitudinal axes, transverse axes, ends, corners and / or the like at least substantially coincide with one another, the mouth-shaped portions 5A', 5B' are similarly oriented so that in particular the first mouth-shaped portion 5A' can be at least substantially pushed into the second mouth-shaped portion 5B' without any deformation of the mouth-shaped portions 5A', 5B'.

[0292] The guides 18A, 18B are preferably configured so that in the (second) connection position or after the attachment connection arrangement 3A', 3B' or after the mouth-shaped parts 5A', 5B' have been inserted or pushed into each other, they can be rotated relative to each other, in particular, around the center axis or axis of symmetry 9. In particular, the guides 18A, 18B comprise slides or parts which extend axially or parallel to the center axis or axis of symmetry 9 and which have radial extensions thereafter to cause the rotational movement described above. However, other solutions are also possible.

[0293] Aspects of the first and second embodiments may also be combined with one another. Thus, the second connection arrangement 3B, 3B' may additionally comprise a splitting element 7 which at least partially opens the opening region 4A, 4A' of the first connection arrangement 3A, 3A' when the connection arrangements 3A, 3A', 3B, 3B' are placed inside one another. The mouth-shaped portions 5A, 5A' can then be used to open, in particular, pierce, the opening region 4B, 4B' of the second connection arrangement 3B, 3B'. Subsequently, the connection arrangements 3A, 3A', 3B, 3B' are rotated relative to one another about the central axis or axis of symmetry 9 resulting in a deformation of one or both mouth-shaped portions 5A, 5A', 5B, 5B'. This results in a tensioning of one or both opening regions 4A, 4A', 4B, 4B'. In this way, further rupture and / or tearing of one or both opening regions 4A, 4A', 4B, 4B' can advantageously be achieved, whereby the fluid connection 2 can be improved or the hydraulic cross section of the fluid connection 2 can be enlarged.

[0294] The connection arrangements 3A, 3A′, 3B, 3B′ are preferably configured to open to one another and / or to complement and / or correspond to one another, such that a continuous fluid connection 2 can be produced.

[0295] The connection arrangement 3A, 3A', 3B, 3B' is preferably configured to produce a flow rate greater than 0.5 cm when the fluid connection 2 is produced. 2, preferably greater than 1 cm 2 , a hydraulic cross section. This allows rapid and complete mixing.

[0296] The connection arrangements 3A, 3A', 3B, 3B' are preferably adapted to be axially inserted into one another, to fit one another, and / or to be formed without threads. This allows the fluid connection 2 to be produced quickly and easily.

[0297] By creating a fluid connection 2 , the fluid connection 2 preferably forms a passage between the containers B1 , B2 , B3 which is isolated from the environment. This prevents the ingress of foreign substances or germs.

[0298] The second connection configuration 3B, 3B' is preferably configured to open the first connection configuration 3A, 3A' by breaking through the first opening area 4A, 4A' and / or the first connection configuration 3A, 3A' is configured to open the second connection configuration 3B, 3B' by breaking through the second opening area 4B, 4B'. An irreversible fluid connection 2 with a large diameter sufficient to allow rapid mixing can be advantageously produced by mutual destruction of the opening areas 4A, 4A', 4B, 4B'.

[0299] Due to the creation of the fluid connection 2, the connection system 1 is preferably self-sealing, in particular, at least one of the opening areas 4A, 4A', 4B, 4B' has a sealing effect due to or after the creation of the fluid connection 2, so that the continuous fluid connection 2 forms a passage isolated from the environment. Preferably, the creation of the fluid connection 2 forms a fluid passage isolated from the environment, in particular, the fluid passage is formed in a fluid-tight, antibacterial and / or airtight manner.

[0300] To this end, one of the opening areas 4A, 4A', 4B, 4B' or the device forming the respective opening area can, after being perforated or otherwise destroyed, serve as a sealing element, in particular a sealing lip, extending between the connection configurations 3A, 3A', 3B, 3B' and in this way sealing the connection configurations 3A, 3A', 3B, 3B' from each other or relative to each other.

[0301] The connection system 1 is preferably self-sealing in a sterile or sterilizable manner due to the creation of the fluid connection 2. In particular, the creation of the fluid connection 2 creates a seal that prevents the entry of germs.

[0302] Preferably, a seal, in particular a sealing ring or a sealing lip, is provided to seal the connection arrangements 3A, 3A', 3B, 3B' relative to each other.

[0303] Preferably, since or after forming the fluid connection 2, at least the opening area 4A, 4A', 4B, 4B', preferably the second opening area 4B, 4B', acts as a seal to isolate the fluid connection 2 preferably from the environment or to seal the fluid passage.

[0304] In particular, it is conceivable that at least the opening area 4A, 4A', 4B, 4B', preferably the second opening area 4B, 4B', has a sealing effect or acts as a seal at least at the edge or forms a sealing ring or a sealing lip when the fluid connection 2 has been formed. Alternatively or in addition, it is conceivable that at least the opening area 4A, 4A', 4B, 4B', preferably the second opening area 4B, 4B', sealably abuts the connection configuration 3A, 3A', 3B, 3B', preferably the first connection configuration or a corresponding connection configuration, in particular the mouth-shaped portion 5A, 5A', 5B, 5B' thereof, when it has been pierced by the mouth-shaped portion 5A, 5A', 5B, 5B', to produce the fluid connection 2.

[0305] At least the opening areas 4B, 4B', preferably at least the opening areas 4A, 4A', 4B, 4B', are preferably constructed to inhibit chipping around the edges and / or to form a seal, and / or they have a material construction or layered structure in the edge area that is different from that of the central part, so that the edge area is more stable and / or acts as a seal after the edge area has been opened.

[0306] In the initial state, the containers B1, B2, B3 of the proposed container system B have preferably been produced separately from one another and can be used separately from one another and / or are fluidically separated from one another. In the initial state, the connection arrangements 3A, 3A', 3B, 3B' are preferably each fluidically sealed independently of one another. After the fluid connection 2 has been formed between the containers B1, B2, B3, these containers are preferably not separated or unreleasably connected.

[0307] Fig.14 A further container B3 is shown which may also be or form part of the container system B. The container system B preferably comprises a container B3. This has two different corresponding and / or complementary connection configurations 3A, 3A', 3B, 3B'. Thus, this container B3 may be used as an adapter between two other containers B1, B2 and / or may be connected to different containers B1, B2 and / or may allow mixing of more than two substances S1, S2, S3.

[0308] The container B3 comprises both the first connection arrangement 3A and the second connection arrangement 3B on different sides, preferably opposite sides. Thus, the container B3 preferably comprises the first connection arrangement 3A, 3A' on a first side and the second connection arrangement 3B, 3B' on a second side remote from the first side. This container preferably has no removal openings E1, E2.

[0309] Furthermore, the further container B3 is configured to produce a fluid connection 2 on both sides by the proposed connection system 1. The further container B3 may comprise or possess another additional substance S3 different from the previous substances S1, S2, in particular a dried or freeze-dried substance (lyophilized powder).

[0310] A plurality of containers B3 can be connected to each other and / or to the first container B1 and / or the second container B2. In this way, three or more substances S1, S2, S3 can be mixed and / or a combination of three or more containers B1, B2, B3 can be formed and / or three or more containers B1, B2, B3 can be fluidly connected to each other.

[0311] If combined Figure 1 As explained, the proposed connection system 1 is preferably used for fluidly connecting bottles or bottle-like containers B1, B2, in particular for the medical field. Preferably, the opening areas 4A, 4B, 4A', 4B' should be adapted to be covered in a sterile manner during transport.

[0312] Fig.15 A schematic perspective view of a first connection arrangement 3A with a splitting element 7 arranged on an opening area 4A is shown. Fig.15 In the embodiment shown, the splitting element 7 has four or (in dashed lines) three legs, but may also have more legs 19. The legs 19 are preferably wedge-shaped at least partially or in regions or have a cutting edge that is away from the opening region 4A. The splitting element 7 preferably has a point 20 that is directed away from the opening region 4A. The point 20 preferably adjoins the leg 19, or vice versa. The shear forces can be increased by the point 20 and / or the leg 19 and the destruction or perforation of the opening region 4B can be promoted. However, other alternative embodiments of the splitting element 7 are theoretically possible.

[0313] In the embodiment shown, the splitting element 7 preferably comprises a foot-shaped connecting portion 21 with the opening area 4B. These can be configured to absorb or distribute the forces applied by the splitting element 7, in particular the point 20 or the foot 19, to the opening area 4A. Alternatively or in addition, the connecting portion 21 can be provided and configured so that when the connecting arrangements 3A, 3B are pushed into each other, the mouth-shaped portion 5B becomes supported on the connecting portion 21 or in the vicinity thereof, whereby shear forces acting on the opening area 4B can be generated or increased. This helps to keep the opening area 4A open.

[0314] The splitting element 7 is preferably configured and / or arranged to pierce, split, cut or destroy the opening area 4A, 4A' of the first connection arrangement 3A, 3A'.

[0315] The split element 7 is preferably arranged and / or fastened to the opening area 4B, 4B' of the second connection arrangement 3B, 3B', in particular, directly arranged and / or fastened to the opening area 4B, 4B' of the second connection arrangement 3B, 3B'. Alternatively or in addition, the split element 7 is arranged to concentrate a force acting on the opening area 4A, 4A' and / or to disperse a force or a counterforce acting on the opening area 4B, 4B', so that when the opening area 4A, 4A' is opened due to the destruction of the split element 7, the opening area 4B, 4B' of the second connection arrangement 3B, 3B' remains intact.

[0316] In another aspect, it is conceivable that the splitting element 7 comprises one or more connecting portions 21 to which or connected to which the splitting element 7 is connected, preferably by material engagement, which have an open area 4A, 4A′, 4B, 4B′.

[0317] The connecting portion 21 preferably forms a weak point of the opening area 4B, 4B' of the second connecting arrangement 3B, 3B'. Preferably, the connecting portion 21 is configured to correspond to the first connecting arrangement 3A, 3A', in particular, its mouth-shaped portion 5A, 5A'. Moreover, the connecting portion 21 is preferably configured so that the forces acting on the opening area 4B, 4B' of the second connecting arrangement 3B, 3B' are concentrated by the first connecting arrangement 3A, 3A'. This makes it easier for the first connecting arrangement 3A, 3A', in particular, its mouth-shaped portion 5A, 5A', to destroy and / or open the opening area 4B, 4B' of the second connecting arrangement 3B, 3B'.

[0318] Fig.16 The proposed container system is shown in a transport position or orientation. Since a portion of the container B1, B2, B3 or the bottleneck F1, F2 forming the removal opening is adapted to be held by the holding device of the cap-shaped cover device 6, the containers B1, B2, B3 are preferably releasably connected to each other during transport.

[0319] The first container B1 preferably has a cover device 6 or the first connection configuration 3A, 3A' is covered by the cover device 6. The second container B2 is received and / or held by the cover device 6, preferably received and / or held in the area of ​​its removal opening E2 or its bottleneck F2 or received and / or held by the area of ​​its removal opening E2 or its bottleneck F2. In this way or by some other components, the containers B1 and B2 of the container system can form a set or a combination that associates the containers B1 and B2 with each other. This can advantageously avoid undesirable combinations of containers B1, B2 or substances S1 and S2.

[0320] The cover device 6 can preferably be retained on the first container B1 and is configured to retain the area of ​​the removal openings E1, E2 or bottlenecks F1, F2 of both the first container B1 and the second container B2. In this way, the cover device 6 has a triple function, i.e., for providing a (sterile) cover, for forming a transport combination and as a support base. The latter will be discussed further below.

[0321] Fig.17 A longitudinal section of a first container B1 is shown, the first connection arrangement 3A being covered, preferably in a sterile manner, by a covering device 6. The covering device 6 may be removably retained on the container B1 by or using one of the fixing devices 10A, 10B or by some other means on the first container B1.

[0322] Preferably, one or both opening areas 4A, 4A', 4B, 4B' are covered in a sterile or sterilizable manner. One of the opening areas 4A, 4A', 4B, 4B' is preferably separated from the environment in a sterile manner by a cap-shaped covering device 6. The (other) opening area 4A, 4A', 4B, 4B' is preferably separated from the environment in a sterile or sterilizable manner by a removable, detachable, tearable and / or film-like closure 14.

[0323] A double closure can be formed by the respective opening area 4A, 4A', 4B, 4B' and the respective sterile or sterilizable cover. In this way, a sterile or sterilizable or sterile sealed area or space or cavity can be formed between the sterile or sterilizable cover and the respective connection arrangement 3A, 3A', 3B, 3B'.

[0324] The sterile or sterilizable cover is preferably removable. This makes it possible to produce a (sufficiently) sterile fluid connection 2 through the connection system 1 by removing the cover and using the opening areas 4A, 4A', 4B, 4B' arranged in the sterile area to form the fluid connection 2.

[0325] In the embodiment shown, the cap-shaped cover device 6 forms the aseptic cover of the first opening area 4A, 4A' and / or the closure 14 forms the aseptic cover of the second opening area 4B, 4B' by sealing or welding or by a film tightly applied in other ways. However, in theory, aseptic cover can also be provided by other means (for example, by using a cap or (screw) closure (using a seal or the like as the case may be), replacing the film, and / or by constructing a cover device 6 that does not have a retaining member or has different retaining devices).

[0326] In the context of the present invention, sterile means in particular at least substantially free of germs or antiseptic. A sterile or sterilizable cover is preferably a device designed to prevent the penetration of germs, in particular by forming a germ-proof barrier.

[0327] From a construction point of view, the sterile or sterilizable cover is preferably tightly applied or connected to the respective connection arrangement 3A, 3A', 3B, 3B' in order to form a germ-proof barrier.

[0328] The cover is sterilizable, in particular when the cover is made of materials suitable for at least sterilization methods known in the prior art for eliminating germs or when the sterile or sterilizable cover comprises or is formed of these materials. For example, these materials can be sterilized by one of the known sterilization methods without damaging them or losing their function as a barrier to the entry of germs. These known sterilization methods include irradiation (in particular, using gamma rays or an electron beam), fumigation, treatment with hot air or autoclave sterilization. Preferably, the connection configurations 3A, 3A', 3B, 3B' are also sterile or sterilizable.

[0329] The opening areas 4A, 4A', 4B, 4B' are preferably produced independently of one another or individually from one another in the initial state and / or are covered individually from one another in a sterile or sterilizable manner. This enables the containers B1, B2, B3 to be used individually.

[0330] A space which is sterile, sterilizable and / or sealed in an aseptic manner or sealed to be airtight and / or antibacterial in the initial state is preferably formed between the opening areas 4A, 4A', 4B, 4B' and the sterile or sterilizable cover or components for the sterile cover, in particular, the cover device 6 and / or the closure 14.

[0331] According to another aspect of the invention which can also be implemented independently, substances, in particular active substances, vaccines and / or adjuvants, are arranged, attached and / or fixed in space. In particular, the substances are arranged in space as a lattice and / or are held by splitting elements 7.

[0332] In a preferred aspect, the splitting element 7 or another part of one of the connection arrangements can be dissolved, dissolved and / or suspended in the space. In this way, after the fluid connection 2 has been formed, substances from the space can form part of the mixture of substances S1, S2, S3.

[0333] The substance arranged in the space can be melted and / or dissolved and / or suspended on the connection arrangement 3A, 3B, 3A', 3B' or the opening area 4A, 4A', 4B, 4B' by one of the substances S1, S2, S3.

[0334] In a preferred aspect, the lyophilized powder is dried onto the opening area or applied to the opening area in other ways. The lyophilized powder and one or more of the substances S1, S2, S3 may contain a vaccine, an active substance and / or an adjuvant for preparing a vaccine or a combination vaccine. In this way, after the fluid connection 2 is generated, the substances disposed in the space may form a component of a substance mixture, in particular, a combination vaccine.

[0335] The components for the sterile cover, in particular the cover device 6 and / or the closure 14 , are preferably removable or detachable, in particular manually or without the use of tools, so that the opening area 4A, 4A′, 4B, 4B′ is accessible for producing the fluid connection 2 .

[0336] One of the containers B1 , B2 , B3 preferably comprises, on a side remote from the removal opening E1 , E2 , a removable cap-like covering device 6 which in the starting position preferably closes the connection arrangement 3A, 3A′, 3B, 3B′ in a sterile manner.

[0337] The cap-shaped cover device 6 preferably comprises a holding device for removing the opening E1, E2 or the bottleneck F1, F2. The holding device, in particular, the receptacle 13, is preferably configured to hold a portion of the container B1, B2, B3, in particular, the bottleneck F1, F2, to form the removal opening E1, E2, E3.

[0338] The cover device 6 preferably comprises a retaining portion shaped like a shoulder and / or shaped to correspond to or be complementary to a shoulder area of ​​the container B1 , B2 adjacent to the removal opening E1 , E2.

[0339] In the illustrated embodiment, the cover device 6 preferably includes a receptacle 13 configured to receive and / or retain the neck portions F1 , F2 of one or two containers B1 , B2 , preferably by interlocking or latching engagement.

[0340] The cover device 6 is preferably embodied as a holder or support for one or two containers B1, B2. For this purpose, the removal opening E1, E2 or the bottleneck F1, F2 can preferably be inserted into the cover device 6. In particular, the container 13 is configured to preferably clamp and / or latch and / or releasably hold one or two containers B1, B2 in the region of the removal opening E1, E2 and / or the bottleneck F1, F2. This advantageously allows reliable operation as a base or support and / or allows holding or forming a set or combination of containers B1, B2, in particular, bottles, of the container system B.

[0341] If one of the containers B1, B2, in particular, the first container B1, has its opening area 4A covered by a cover device 6, the cover device 6 is preferably used as a base or support surface of the container. It can be provided that the container 13 is arranged at the bottom in the starting position and / or can be accessed from the outside. This has the following additional advantage: the first container B1 including the cover device 6 with the container 13 can be placed on the second container B2 and the containers B1, B2 can be stacked by making the removal opening E2 or the bottleneck F2 of the second container B2 be pushed into the container 13 and preferably especially by latching and / or clamping and holding the way. In this way, a set can be produced, wherein the containers B1, B2 can be releasably engaged together to thereby help to prevent incorrect packaging and wrong mixing of substances using the connection system 1.

[0342] In order to use the proposed connection system 1, it is conceivable that the cover device 6 is first separated from the first container B1 or removed from the first container B1 (see Fig.18 ).

[0343] Then, if Fig.19 , for example, the removal opening E1, E2 or the bottleneck F1, F2 of the first container B1 (or alternatively, the second container B2) or a part thereof is preferably inserted into the receiving groove 13 of the cover device 6. For this purpose, a cover device 6 can be used, wherein the opening of the receiving groove 13 is guided upward in the use position, and the removal opening E1, E2 or the bottleneck F1, F2 is at least partially pushed into the receiving groove 13 from above in the use position. However, in theory, the containers B1, B2 can also be inserted into the receiving groove 13 in other positions. Then, preferably, the cover device 6 is used as a bracket or base or is located at the bottom in the use position. Therefore, the first connection configuration 3A or its opening area 4A can be accessed from above in the use position.

[0344] If the container B1 , B2 , B3 having the portion forming the removal opening E1 , E2 or the bottleneck F1 , F2 is held by the holding device or the receptacle 13 , the cover device 6 can be used as a supporting base for the container B1 , B2 , B3 .

[0345] Thus, the cover device 6 preferably forms a seat or base for the container B1, B2 held by the cover device 6. The dual function of the cover device advantageously saves space and material, and in addition, using the cover device 6 as a seat or base advantageously protects the connection arrangement 3A, 3A', 3B, 3B' from contamination.

[0346] The cover device 6 preferably has a cap-like outer shape and, in the starting or transport position, forms a seal together with the connecting arrangement 3A, 3A', 3B, 3B' in order to produce a sterile or sterilizable closure.

[0347] The cover device 6 preferably comprises a receiving groove 13 and a holding portion for holding the connection configuration 3A, 3A', 3B, 3B' on different sides, in particular, opposite sides. The holding portion may have a region that can be releasably fixed to the connection configuration 3A, 3A', 3B, 3B' or can be fixed to the connection configuration 3A, 3A', 3B, 3B' by clamping and / or latching action. For this purpose, the cover device 6 and the connection configuration 3A, 3A', 3B, 3B' in the holding portion may have a complementary or corresponding construction.

[0348] The cover device 6 is preferably made of plastic or contains plastic. The cover device 6 is preferably a thermoformed part or an injection molded part and / or a shaped part produced by a sheet of material. The cover device 6 preferably has a wall thickness greater than 1 mm and / or less than 2 mm. However, other solutions are also feasible here.

[0349] In the embodiment shown, the cover device 6 essentially has a W-shaped or U-shaped longitudinal section with a U-shaped recess forming the receptacle 13. However, the cover device 6 can also be formed in a different way to have a dual function as a sterile closure on the one hand and as a retaining device on the other hand.

[0350] Fig. 20 A second container B2 is shown, wherein the opening area 4B is closed by a closure 14, in particular a removable cover, a film, a sealing film or the like, in particular in a sterile manner. Preferably, the closure 14 is removable, in particular removable by peeling off, in order to use the proposed connection system 1. For this purpose, the closure 14 can have a tab.

[0351] At least one of the connection arrangements 3A, 3A', 3B, 3B', specifically the second connection arrangement 3B, 3B' in the embodiment shown, preferably has a receiving groove for the other of the connection arrangements 3A, 3A', 3B, 3B', which can preferably be formed by a sleeve ring-shaped portion 22 or alternatively or additionally by some other member. The sleeve ring-shaped portion 22 can facilitate the connection arrangements 3A, 3A', 3B, 3B' to cooperate with each other, guide the required movement, and / or protect the connection arrangements 3A, 3A', 3B, 3B' at both sides. The sleeve ring-shaped portion 22 preferably includes the fixing device 10A, 10B or a part thereof.

[0352] Preferably, one of the connection arrangements 3A, 3A′, 3B, 3B′, in particular the second connection arrangement 3B, 3B′, is surrounded by the collar-like portion 22 in the (first and / or second) connection position.

[0353] The collar-like portion 22 is preferably used to receive the (respective) further connection arrangement 3A, 3A′, 3B, 3B′ or to form a receptacle and / or a guide, preferably for this purpose, in particular a linear guide in the direction of the center axis or axis of symmetry 9 .

[0354] In the embodiment shown, the collar-like portion 22 is provided on or around the second connection arrangement 3B, 3B' or on the second container B2. However, alternatively or additionally, the collar-like portion 22 may also be provided around the first connection arrangement 3A, 3A' or on the first container B1.

[0355] Preferably, the ring-shaped portion 22 is fixedly, rigidly and / or non-rotatably connected to one or an associated connection configuration 3A, 3A', 3B, 3B', preferably by interlocking engagement (in particular, by latching) and / or by friction engagement (in particular, by clamping) and / or by material connection (in particular, by adhesive bonding or injection molding), and alternatively, by being integrally formed with the connection configuration 3A, 3A', 3B, 3B' or one of the containers B1, B2.

[0356] The ring-shaped portion 22 preferably protrudes beyond the mouth-shaped portion 5A, 5B, 5A', 5B' and / or extends at least partially parallel to the mouth-shaped portion 5A, 5B, 5A', 5B' or in the same direction and preferably thereby forms a receiving groove or linear guide for another of the connection configurations 3A, 3A', 3B, 3B'.

[0357] The collar-like portion 22 or the receptacle which can be formed thereby preferably at least partially comprises guide elements 18A, 18B, in particular slides, guide pins or the like.

[0358] The open edge of the collar-like portion 22 preferably forms a stop for the connection arrangement 3A, 3A', 3B, 3B' which, in the disconnected state of the connection arrangement 3A, 3A', 3B, 3B', does not surround and / or serve to connect the container B1 thereto. Preferably, in the second connection position, the connection arrangements 3A, 3A', 3B, 3B' butt against each other in the region of the stop.

[0359] The collar-like portion 22 is preferably closed at one end or on the open side by a closure 14 , in particular a film applied as a seal, in particular in a sterile manner.

[0360] Fig.21By way of example it is shown how containers B1, B2 can be fluidically connected to one another by means of the proposed connection system 1. For this purpose, the closure 14 is preferably removed from the second container B2 and then the second container B2 is placed from above together with the second connection arrangement 3B, 3B' onto the first connection arrangement 3A, 3A'. In the embodiment shown, the first connection arrangement 3A, 3A' extends into the receptacle formed by the collar-shaped portion 22.

[0361] Next, the opening regions 4A, 4A', 4B, 4B' are opened. The fluid connection 2 can be produced by combining the connection arrangements 3A, 3B (in particular, they form the base region of the bottle or bottle-like container B1, B2), as has been described with respect to Figures 2 to 8 Explained. Fig.21 A first embodiment is shown, but the same applies to a second embodiment and combinations of embodiments.

[0362] According to another aspect of the invention, which can also be implemented independently, the connection system 1 or the connection arrangement 3A, 3B, 3A', 3B' is dedicated to containers of a certain size.

[0363] In particular, the proposed container system B comprises containers B1, B2, B3 of different sizes, volumes and / or with specific amounts of substances S1, S2, S3 for producing a desired mixing ratio. For this purpose, it is preferred that the connection configurations 3A, 3B, 3A', 3B' are selectively configured (mechanically) so that containers B1, B2, B3 with compatible contents can be connected and containers B1, B2, B3 with incompatible contents or containers B1, B2, B3 that would lead to an undesirable or unsuitable mixing ratio when producing the fluid connection 2 have connection configurations 3A, 3B, 3A', 3B' that are mechanically incompatible with each other.

[0364] Preferably, the connection arrangements 3A, 3B, 3A', 3B' can be selectively configured relative to each other, in particular according to the lock and key principle. This can be achieved using guides 18A, 18B, guide slides, diameters or the like that are compatible or incompatible with each other, respectively.

[0365] Combination Figures 16 to 21 The aspect of the present invention described itself and its various combinations can be advantageous, preferably, completely or partially or in some details according to the sequence of explanation. Particularly, before the second connection configuration 3B is opened or unsealed, especially by removing the closure 14, preferably the cover device 6 is removed and used as a bracket or base.

[0366] and, Figures 16 to 21The connection configurations 3A, 3B of the first embodiment are shown. However, as an alternative to these, the connection configurations 3A', 3B' of the second embodiment or a combination of the first connection configuration 3A, 3A' and the second connection configuration 3B, 3B' may also be used. Next, the explained aspects are applied accordingly.

[0367] Thus, alternatively or additionally, the fluid connection 2 can be produced by deformation. In this case, the splitting element 7 is optional and the collar-like portion 22 preferably has a non-circular cross section, so that when the connection arrangements 3A, 3B, 3A', 3B' are rotated relative to each other, the fluid connection 2 is produced by shaping or deformation. For the sake of brevity, the corresponding procedure will not be repeated here.

[0368] Further aspects of the invention will be described in more detail below, which can be implemented alone and in combination with each other and / or can be implemented together with the aspects and features of the invention as explained above and which are advantageous.

[0369] One aspect of the present invention, which can be implemented independently or together with one or more of the aforementioned aspects, relates to a connection system 1 for producing a fluid connection 2, preferably a fluid connection 2 between containers B1, B2, B3, wherein the connection system 1 includes at least two connection configurations 3A, 3A', 3B, 3B' configured to form the fluid connection 2, i.e., a first connection configuration 3A, 3A' and a second connection configuration 3B, 3B', which are respectively fluid-sealed and independently sealed from each other in an initial state, and the connection configurations 3A, 3A', 3B, 3B' are capable of being inserted into each other and / or adapted to be inserted into each other, preferably by at least substantially linear and / or axial movement along a common axis, thereby allowing at least one of the connection configurations 3A, 3A', 3B, 3B' to be opened.

[0370] In particular, the fluid connection 2 is formed by an insertion process. This is advantageously implemented, for example, by producing the fluid connection 2 particularly quickly and reliably, in particular without having to repeatedly rotate the connection arrangement 3A, 3A', 3B, 3B' by means of a helix with a number of turns or by means of a thread.

[0371] Inserting the connecting configurations 3A, 3A', 3B, 3B' into one another also allows the connecting configurations 3A, 3A', 3B, 3B' to be combined together in a manner oriented relative to one another with respect to the rotational position around the (common) axis of symmetry or center axis 9, which is particularly advantageous when the mouth-shaped parts 5A, 5A', 5B, 5B' of the connecting configurations 3A, 3A', 3B, 3B' have a non-circular cross-section or when the opening of at least one of the connecting configurations 3A, 3A', 3B, 3B' is produced by deformation of the opening area 4A, 4A', 4B, 4B' and the resulting tensioning.

[0372] One aspect of the present invention, which can also be implemented independently or together with one or more of the aforementioned aspects, relates to a connection system 1 for producing a fluid connection 2, preferably a fluid connection 2 between containers B1, B2, B3, wherein the connection system 1 includes at least two connection configurations 3A, 3A', 3B, 3B' configured to produce the fluid connection 2, namely, a first connection configuration 3A, 3A' and a second connection configuration 3B, 3B', which are fluid-sealed in an initial state, and the first connection configuration 3A, 3A' in particular has a film-like, brittle and / or unstable opening area 4A, 4A', which can be deformed outside the opening area 4A, 4A', and is configured so that the deformation causes the opening area 4A, 4A' of the first connection configuration 3A, 3A' to open.

[0373] An aspect of the invention which may also be implemented independently or together with one or more of the aforementioned aspects relates to one or more containers B1 , B2, B3 or conduits comprising a connection arrangement 3A, 3A', 3B, 3B', respectively.

[0374] One aspect of the present invention, which can also be implemented independently or together with one or more of the aforementioned aspects, relates to a connection system 1 for producing a fluid connection 2, preferably a fluid connection 2 between containers B1, B2, and B3, the connection system 1 having at least two connection configurations 3A, 3A', 3B, and 3B' configured to produce the fluid connection 2, the connection configurations 3A, 3A', 3B, and 3B' respectively including opening areas 4A, 4A', 4B, and 4B' that are fluid-sealed in an initial state, in particular, fluid-sealed in the manner of a film, or are brittle, fragile and / or unstable, and the opening areas 4A, 4A', 4B, and 4B' are each covered in a sterile or sterilizable manner.

[0375] Thus, in particular, the opening or formation of the fluid connection 2 is achieved by the fact that the opening area 4A, 4A' of the first connection configuration 3A, 3A' is or forms a weak point, so that the first connection configuration 3A, 3A', in particular by tensioning deformation, leads to tearing or rupture of the opening area 4A, 4A'. This has the following specific advantages: this opening process does not require points or other splitting elements. The splitting element 7 usually has to be sharpened and stabilized to allow the opening area 4A, 4A', 4B, 4B' to open. Therefore, by avoiding this splitting element, the process can use softer materials and / or be simpler. However, as explained above, a combination of the above-mentioned aspects of using the splitting element 7 is also feasible, and this aspect is also conducive to enlarging or extending the opening or fluid connection 2.

[0376] The sterile or sterilizable cover of the opening area 4A, 4A', 4B, 4B' can advantageously produce the fluid connection 2 while preventing the entry of germs or other foreign substances in the pharmaceutical / medical field in particular. Alternatively or in addition, the sterile or sterilizable cover of the opening area 4A, 4A', 4B, 4B' provides the possibility of using containers B1, B2, B3 with connection configurations 3A, 3A', 3B, 3B', which containers B1, B2, B3 are separated from each other in this environment and can be combined with each other as appropriate.

[0377] One aspect of the present invention, which can also be implemented independently or together with one or more of the aforementioned aspects, relates to a container system B, which has at least two containers B1, B2, B3, preferably bottles, and a connection system 1, wherein the containers B1, B2, B3 for providing a fluid connection 2 between the containers B1, B2, B3 respectively include at least one connection configuration 3A, 3A', 3B, 3B' of the connection system 1.

[0378] In this connection, the use of the proposed connection system 1 to connect the containers B1, B2, B3 has proven to be particularly advantageous, since a non-releasable and / or irreversible fluid connection 2 can be produced between the containers B1, B2, B3 to thereby ensure complete mixing of the contents of the containers B1, B2, B3.

[0379] Another aspect of the present invention, which can also be implemented independently or together with one or more of the aforementioned aspects, relates to a container system B, which has at least two containers B1, B2, B3, preferably bottles, each of the containers B1, B2, B3 including a removal opening E1, E2, which is preferably closed by a diaphragm, and the containers B1, B2, B3 preferably include a connection configuration 3A, 3A', 3B, 3B' for providing a fluid connection 2 between the containers B1, B2, B3 on one side away from the respective removal opening E1, E2, in particular, on the base of each bottle and / or are configured to provide a fluid connection 2 between the containers B1, B2, B3.

[0380] The use of two containers B1, B2, B3 (each of which includes a removal opening E1, E2 and a connecting configuration 3A, 3A', 3B, 3B') is particularly advantageous because the containers B1, B2, B3 can also be used individually from one another, but at the same time, if used in combination via the connecting configuration 3A, 3A', 3B, 3B', a fluid connection with a relatively large cross-section can be formed to quickly or accelerate mixing of the contents of the containers B1, B2, B3.

[0381] Another aspect of the present invention, which may also be implemented independently or together with one or more of the aforementioned aspects, relates to a method for providing a fluid connection 2 between connection configurations 3A, 3A', 3B, 3B' and / or providing a fluid connection 2 between containers B1, B2, B3 by means of connection configurations 3A, 3A', 3B, 3B', wherein in an initial state, the connection configurations 3A, 3A', 3B, 3B' are respectively fluid-sealed, wherein a first connection configuration 3A, 3A' is opened by another second connection configuration 3B, 3B' and the second connection configuration 3B, 3B' is opened by the first connection configuration 3A, 3A' to thereby create a continuous fluid connection 2 between the connection configurations 3A, 3A', 3B, 3B'.

[0382] This leads to corresponding advantages, namely, in particular, a rapid and reliable production of the fluid connection 2 or the mixing of the substances S1 , S2 , S3 .

[0383] Another aspect of the present invention, which can also be implemented independently or together with one or more of the aforementioned aspects, relates to the use of a container system B for preparing a mixture of substances, in particular, for preparing a combination vaccine for simultaneous immunization against different diseases, wherein a first container B1 contains a first substance S1, in particular, a second vaccine for preventing a first disease, and a second container B2 contains a second substance S2, in particular, a second vaccine for preventing a second disease different from the first disease, wherein the containers B1, B2, B3 are fluidically connected to each other by connecting arrangements 3A, 3A', 3B, 3B', so that the substances are mixed together to form a combination vaccine.

[0384] The use of the proposed connection system 1 or container system B for the preparation of a combination vaccine is advantageous, for example, because the vaccines can be used individually or in combination as desired. The proposed connection system 1 or container system B provides the flexibility to decide on the spot whether to administer the substances S1, S2, S3 or the vaccine individually or in combination. This advantageously avoids the animals being stressed by unnecessary large numbers of individual injections or always having to unnecessarily vaccinate the animals with a combination vaccine, even if one of the vaccines does not need to be administered due to an existing immunity. In this way, the invention can save materials and costs.

[0385] Another aspect of the present invention, which can also be implemented independently or together with one or more of the aforementioned aspects, relates to a method for providing a fluid connection 2 between connection configurations 3A, 3A', 3B, 3B' and / or providing a fluid connection 2 between containers B1, B2, B3 by means of connection configurations 3A, 3A', 3B, 3B' of a connection system 1, wherein preferably components for the sterile cover, in particular the cover device and / or the closure 14, are each removed from the opening areas 4A, 4A', 4B, 4B', and the thus exposed still closed opening areas 4A, 4A', 4B, 4B' are opened to form the fluid connection 2.

[0386] Another aspect of the present invention, which may also be implemented independently or together with one or more of the aforementioned aspects, relates to a method for providing a fluid connection 2 between connection configurations 3A, 3A', 3B, 3B' and / or providing a fluid connection 2 between containers B1, B2, B3 by means of connection configurations 3A, 3A', 3B, 3B', wherein in an initial state, the connection configurations 3A, 3A', 3B, 3B' are respectively fluid-sealed, while a first connection configuration 3A, 3A' is opened by another second connection configuration 3B, 3B' and the second connection configuration 3B, 3B' is opened by the first connection configuration 3A, 3A' to thereby create a continuous fluid connection 2 between the connection configurations 3A, 3A', 3B, 3B'.

[0387] In another aspect, which can therefore be implemented independently, the invention relates to a set having two of the proposed containers B1, B2, B3 or having containers B1, B2, B3 which can be fluidically connected to one another by means of a connection system 1 so that a mixture of the substances S1, S2, S3 contained in the containers B1, B2, B3 can be formed. This prevents mixing of other incompatible substances S1, S2, S3.

[0388] In the context of the present invention, a set refers in particular to a combination and / or system comprising a first container B1 and a second container B2, which form components of the set. The set may also comprise a third container B3 and / or further containers or components.

[0389] The components of the set are preferably purchased on the market as a set, in particular in a combined package or the like. However, it is also possible to form the components into a loose combination to be used together. A common or connecting component may be provided, such as a set of common instructions for use, disposal advice, text information on one or more of the components of the set or the like.

[0390] Preferably, the containers B1 , B2 , B3 form a set by being held together, preferably by means of a cover device 6 or a receptacle 13 .

[0391] The containers B1, B2, B3 are preferably designed for the preparation of a combination vaccine for simultaneous immunization against different diseases, preferably by enabling the containers B1, B2, B3 to be fluidically connected to each other via connection configurations 3A, 3A', 3B, 3B', so that the substances S1, S2, S3 located in the containers B1, B2, B3 are mixed together to form a combination vaccine, and in particular, the substances S1, S2, S3 can be removed through removal openings E1, E2 separated from each other and then used, in particular, before the fluid connection 2 is formed or when the fluid connection 2 is not formed.

[0392] Preferably, at least one of the containers B1, B2, B3 comprises a removal opening E1, E2, which is preferably closed using a diaphragm, while the containers B1, B2, B3 are preferably configured on a side away from the removal opening E1, E2, in particular, on the bottom of the bottle, for providing a fluid connection 2 between the containers B1, B2, B3 and / or include a connection configuration 3A, 3A', 3B, 3B'.

[0393] The containers B1 , B2, B3 are preferably fluidly connected to each other by means of a connection arrangement 3A, 3A', 3B, 3B' so that the substances are mixed together to preferably form a combination vaccine.

[0394] In another aspect, which can therefore be implemented independently, the invention relates to the use of the proposed connection system 1 , set or container system B for preparing or providing a medicament and / or for medical purposes to a living animal, preferably a mammal.

[0395] In another aspect, which can therefore be implemented independently, the present invention relates to the use of the proposed connection system 1, kit or container system B for preparing and / or providing a vaccine, in particular, the vaccine is used for immunizing against porcine circovirus disease "PCVD" and / or enzootic pneumonia "EP" or porcine circovirus infection and / or mycoplasma strain (in particular, Mycoplasma hyopneumoniae) infection, preferably, for immunizing against porcine circovirus disease "PCVD" and enzootic pneumonia "EP" or porcine circovirus infection and / or mycoplasma strain (in particular, Mycoplasma hyopneumoniae) infection.

[0396] For this purpose, the proposed first container B1 contains the first reactant as first substance S1 and the proposed second container B2 contains the second reactant as second substance S2. The reactants may be vaccines for the prevention of different diseases or the isolate may contain vaccines for the prevention of different diseases.

[0397] Preferably, the first reactant contains only one of the components mycoplasma vaccine or mycoplasma antigens and circovirus vaccine or circovirus antigens (and optionally other substances). Therefore, the first reactant may contain a mycoplasma vaccine or one or more mycoplasma antigens or instead contain a circovirus vaccine or one or more circovirus antigens. In particular, if the reactants are unstable together for a long time, the first reactant is preferably stored separately from the second reactant. The second reactant preferably contains only the other of the components mycoplasma vaccine or one or more mycoplasma antigens and circovirus vaccine or one or more circovirus antigens (and optionally other substances). Therefore, if the first reactant contains a mycoplasma vaccine or one or more mycoplasma antigens, the second reactant contains a circovirus vaccine or one or more circovirus antigens, or vice versa.

[0398] The mycoplasma vaccine may contain not only attenuated and / or inactivated bacteria, bacterial fragments or recombinantly prepared parts of Mycoplasma hyopneumoniae, but also at least one or more Mycoplasma hyopneumoniae antigens. Preferably, the Mycoplasma hyopneumoniae antigens are derived from Mycoplasma hyopneumoniae strain J or inactivated Mycoplasma hyopneumoniae strain J bacteria. Furthermore, the mycoplasma vaccine may be one of the following vaccines or the Mycoplasma hyopneumoniae antigen may be one or several antigens contained in one of the following vaccines: MycoFlex (Boehringer Ingelheim Vetmedica, St. Joseph, MO, USA), Porcilis M.hyo, Myco BPM、Myco BPME、Myco ME, Myco M. Myco Once, Myco MEH (all from Intervet, Millsboro, USA), Stellamune Mycoplasma (Pfizer, New York, NY, USA), Suvaxyn Mycoplasma, Suvaxyn M.hyo, Suvaxyn MH-One (all from Fort Dodge Animal Health, Overland Park, KS, USA (now Pfizer Animal Health)).

[0399] The circovirus vaccine may contain attenuated and / or inactivated porcine circovirus, preferably porcine circovirus type 2, in particular, ORF2 protein type 2. Preferably, a recombinantly expressed ORF2 protein of porcine circovirus type 2, preferably expressed in an in vitro cell culture medium and obtained from an in vitro cell culture medium, is used. Examples of ORF2 proteins of porcine circovirus type 2 are particularly described in the international patent application WO2006-072065. These examples have proven to be particularly advantageous for effective vaccination. Moreover, the circovirus vaccine may be one of the following vaccines or the circovirus antigen may be one or several antigens contained in one of the following vaccines: CircoFLEX (Boehringer Ingelheim Vetmedica, St Joseph, MO, USA), (Merial SAS, Lyon, France), CircoVent (Intervet, Millsboro, DE, USA), or Suvaxyn PCV-2One (Fort Dodge Animal Health, Kansas City, KA, USA).

[0400] If the circovirus vaccine contains ORF2 protein, the content of ORF2 protein per administered dose is preferably between 2 μg and 150 μg, preferably between 2 μg and 60 μg, more preferably between 2 μg and 50 μg, more preferably between 2 μg and 40 μg, more preferably between 2 μg and 30 μg, more preferably between 2 μg and 25 μg, more preferably between 2 μg and 20 μg, more preferably between 4 μg and 20 μg, more preferably between 4 μg and 16 μg. The circovirus vaccine is preferably prepared or formulated so that 1 ml of the vaccine corresponds to 1 dose. In particular, the circovirus vaccine may contain an ORF2 protein content of greater than 2 μg / ml (preferably greater than 4 μg / ml) and / or less than 150 μg / ml (preferably less than 60 μg / ml, 50 μg / ml, 40 μg / ml, 30 μg / ml or 25 μg / ml, in particular less than 20 μg / ml). This facilitates reliability of administration.

[0401] If the mycoplasma vaccine contains inactivated mycoplasma virus, preferably inactivated Mycoplasma hyopneumoniae, each dose preferably contains 10 3 to 10 9 Colony forming units (CFU), preferably 10 4 to 10 8 CFU, preferably 10 5 to 10 6 The Mycoplasma vaccine is preferably prepared or formulated so that 1 ml of the vaccine corresponds to 1 dose. In particular, the Mycoplasma vaccine may contain more than 10 CFU, especially before the inactivation of the bacteria. 3 CFU / ml (preferably greater than 10 4 CFU / ml, especially greater than 10 5 CFU / ml) and / or less than 10 9 CFU / ml (preferably less than 10 8 CFU / ml, especially less than 10 7 CFU / ml or 10 6 CFU / ml), preferably inactivated Mycoplasma hyopneumoniae.

[0402] At least one of the reactants and / or the vaccine or the combination vaccine may contain an adjuvant, preferably a polymeric adjuvant, in particular, carbomer. Preferably, at least one or only one of the two reactants, preferably both reactants, contains an adjuvant amount of 500 μg to 5 mg, preferably 750 μg to 2.5 mg, more preferably about 1 mg per dose. The reactants are preferably prepared or formulated so that 1 ml of each reactant corresponds to 1 dose. The use of an adjuvant (preferably a polymeric adjuvant, such as, for example, carbomer) has been shown to be beneficial to the efficacy or duration of the efficacy of immunization. However, the use of alternative and / or additional adjuvants is not excluded.

[0403] According to another aspect of the invention, the first and / or second and / or combination of first and second containers B1, B2, B3 with the provided fluid connection 2 can be configured for use in or with and / or in an injection device. In particular, it is a reusable injection device (e.g., an injection gun, a pressure syringe and / or a self-filling syringe), which, for example, is of the type used for vaccinating a large number of animals.

[0404] The set or container system B according to the invention may comprise such an injection device or may be associated with it. In particular, the removal opening E1, E2 or another opening, a flange or other connection or closure element of at least one of the containers B1, B2 and / or both containers B1, B2 may be configured so as to allow direct use in or with the injection device. Moreover, the removal device, the opening, the flange or other connection or closure element may be specifically configured for connection to a specific injection device. This can reduce the possibility of incorrect use, in particular, the wrong amount of active substance or the wrong method of administration.

[0405] One aspect of the invention, which can also be implemented independently, further relates to an injection device having an inserted combination of at least two of the proposed containers B1, B2, B3, which are fluidically connected to one another by means of a connection arrangement 3A, 3A', 3B, 3B' according to the invention. In particular, a mixture of substances S1, S2, S3 from the containers B1, B2, B3 is formed by means of a fluid connection 2 and the injection device is configured for injecting the mixture of substances S1, S2, S3.

[0406] Further aspects of the invention will be explained below with reference to another embodiment, which only details the differences and special features compared to the embodiment described above. Therefore, unless explicitly excluded, an aspect can be combined with an aspect previously described, and vice versa. Furthermore, reference will be made to the previous explanations and definitions.

[0407] The following will refer to Fig. 22The embodiment described in the figures and the subsequent figures preferably relates to a variant of the embodiment described above, wherein the first connection arrangement 3A' can be deformed outside the opening area 4A' and is configured such that the deformation causes the first connection arrangement 3A' to open in the opening area 4A'. For further details, reference can be made to Figures 5 to 13 and related explanations.

[0408] According to an aspect of the invention which can also be implemented independently, the first connection arrangement 3A' can preferably include a rigid, hard and / or dimensionally stable closing device 23, in particular a closing plate. The closing device 23 is preferably sealingly attached to the holding portion 25 via a frangible weak point 24, in particular a thin point. Thus, the opening area 4A' of the first connection arrangement 3A' can use or be formed by the closing device 23 and / or the weak point 24.

[0409] The aspects explained previously in connection with the fragility of the opening area 4A', in particular with regard to material thickness and the like, can preferably be applied or transferred to the weak point 24. The difference therefore lies in particular in the fact that the opening area 4A' of the first connection arrangement 3A' additionally comprises a closing device 23 which stabilizes or reinforces the central part of the opening area 4A' or a part surrounded by the film-like, brittle, unstable and / or fragile area in the form of the weak point 24.

[0410] The holding portion 25 preferably corresponds to the mouth-shaped portion 5A' of the first connection configuration 3A' and / or the mouth-shaped portion 5A' comprises the holding portion 25. Therefore, in an alternative or complementary capacity, the relevant explanations in connection with the mouth-shaped portion 5A' can also apply to the holding portion 25. Therefore, if necessary, the holding portion 25 can also be designated as the mouth-shaped portion 5A' or be completely or partially formed thereby, or vice versa.

[0411] Preferably, the retaining portion 25 can be moved relative to the closing device 23 by deformation, so that the first connection configuration 3A' can be opened by tearing the weak point 24. It has been found that the use of the closing device 23 and the accompanying concentration of the forces exerted by the deformation on the fragile area (weak point 24) surrounding the closing device 23 can advantageously achieve a particularly reliable and simpler opening by deformation.

[0412] Fig. 22 An overview of a container system B is shown, in which containers B1, B2 are fluidically connected to each other via connection arrangements 3A', 3B'. For this purpose, a first connection arrangement 3A' or its opening area 4A' and a second connection arrangement 3B' or its opening area 4B' are each shown open.

[0413] For the following explanation, please refer to Figure 23 to Figure 26 ,at the same time Fig.23A longitudinal section through a first container B1 with a first connection configuration 3A' is shown in an initial state, wherein the opening area 4A' has been closed. Fig.24 An enlarged detail of a portion of the closure device 23 and the retaining portion 25 is shown, wherein the weak point 24 is located between the closure device 23 and the retaining portion 25. Fig.23 In the illustrated embodiment, the opening area 4A' is preferably covered by a cap-shaped covering device 26. Fig.25 In the embodiment shown, the cover device 26 has been removed. Fig.26 A perspective view of a first connection arrangement 3A′ as part of a first container B1 without a cover device 26 is shown.

[0414] The closure device 23 is preferably configured and / or retained by means of the weak point 24 so that the closure device 23 tilts as the retaining portion 25 deforms.

[0415] Preferably, the weak point 24 or the surface or plane 27 formed or defined by the weak point 24 is inclined relative to the central axis or axis of symmetry 9. This enables or facilitates pushing, rotating and / or further tilting of the closure device 23 during the opening process or prevents the closure device 23 from blocking the retaining portion 25.

[0416] During the opening procedure, the closing device 23 can slide on the holding portion 25 due to the deformation of the holding portion 25 , in particular when the closing device 23 is tilted.

[0417] The holding part 25 preferably comprises a frame 28 or has a frame-like construction. In the initial state, the closing device 23 is preferably tilted relative to the frame 28. Therefore, the frame 28 and the closing device 23 are each partially offset from each other, so that the offset directly adjacent to the weak point 24 can form this or an offset area. The offset is preferably aligned in opposite directions on opposite sides. The advantage of the offset is that during the deformation of the holding part 25, the closing device 23 can be slid along the frame 28 or inserted behind it. This makes the opening procedure easier, because the deformation of the holding part 25 is prevented from being blocked by the closing device 23 and thus the opening of the opening area 4A' is easier.

[0418] Preferably, a shearing action of the closure device 23 relative to the frame 28 can be generated or achieved during deformation, in particular by a gradual offset of the frame 28 relative to the edge of the closure device 23 adjacent to the weak point 24 and / or due to an inclination of the closure device 23 and / or the weak point 24 relative to the central axis 9. This shearing action can advantageously exert strong mechanical stresses on the weak point 24 relative to the deformation degree of the holding portion 25, in particular by generating tensile and / or shearing stresses, so as to facilitate the splitting or tearing of the weak point 24. Overall, this provides a comfortable and reliable way to open the opening area 4A' of the first connection arrangement 3A'.

[0419] According to another aspect of the invention, the closure device 23 is formed in a ramp shape starting from a weak point 24 provided on its edge. This can be achieved by preferably increasing the material thickness relative to a surface or plane 27 defined by or extending through the weak point 24. Alternatively or in addition, the closure device 23 is formed in a ramp shape starting from the offset area. In this way, the closure device 23 can be tilted continuously as the deformation of the holding portion 25 develops. The ramp-shaped portion of the closure device 23 can slide along the holding portion 25 and thereby produce an increasing tilt.

[0420] The closure device 23 itself preferably comprises a reinforcement 29 which will improve the mechanical stability, in the embodiment shown, in the form of ribs or some other additional material or additional material thickness. This reinforcement 29 can be formed at the edge of the closure device 23 or can be configured like a slope starting from a weak point 24 provided at the edge, in particular so that the closure device 23 tilts continuously as the deformation develops.

[0421] Such as (for example) Fig.26 As can be seen from the perspective view in FIG. 1 , the retaining portion 25 is preferably non-circular perpendicular to the central axis or axis of symmetry 9, in particular, has an elliptical shape, as previously described in connection with FIG. Figures 5 to 13 Alternatively or additionally, this also applies to the weak point 24 and / or to the surrounding edge of the closure device 23 or to this edge adjoining the weak point 24 and / or to the frame 28.

[0422] The weak point 24, in particular the thin point, is preferably fragile, so that a deformation of the retaining portion 25 can lead to tearing of the weak point 24 and thus to opening of the connecting arrangement 3A'.

[0423] In the embodiment shown, the fragile point 24 is only 10 microns thick, preferably less than 300 microns, more preferably less than 200 microns or less than 150 microns. The distance between the holding portion 25 and the closure device 23 tightly bridged by the fragile point 24 is preferably less than 3 mm, in particular, preferably less than 2 mm or 1 mm, in the embodiment shown, less than 0.5 mm. In addition, preferably, the distance between the closure device 23 and the holding portion 25 or the length of the fragile point 24 does not exceed or only slightly exceeds the corresponding value in the entire area surrounding the closure device 23. Therefore, the area of ​​the fragile point 24 around the closure device 23 preferably has at least substantially constant length and / or material thickness. Therefore, the fragile point 24 preferably at least substantially completely surrounds the closure device 23.

[0424] The holding portion 25 is preferably deformable by being inserted into a deformation device 30 of at least substantially complementary shape and subsequently rotating the holding portion 25 relative to the deformation device 30 about the central axis and / or the axis of symmetry 9. In particular, the holding portion 25 is deformable radially relative to the central axis and / or the axis of symmetry 9 and / or in the direction of the central axis or the axis of symmetry 9.

[0425] Fig. 27 shows a cross section through a second container B2 having a second connection configuration 3B' and Fig.28 Shows its enlarged detail. Fig.29 The second container B2 is shown with the cover device 6 removed and Fig.30 A perspective view showing a second connection configuration 3B'.

[0426] Preferably, the deformation means 30 is formed by the second connection arrangement 3B', in particular its mouth-shaped portion 5B'. Figures 5 to 13 The corresponding explanation and Fig. 22 And the following explanation of the second connection configuration 3B' of the embodiment shown in the subsequent figures.

[0427] The retaining portion 25 of the first connection arrangement 3A' is preferably in the shape of a neck, a collar and / or a tube having and in particular formed by a flexibly deformable wall 31. Fig. 22 In the embodiment shown in the following figures, the wall 31 preferably forms an at least substantially conical shape converging towards the frame 28, where it can form the mouth-shaped portion 5A'. However, other solutions are also theoretically possible here.

[0428] Furthermore, preferably, the retaining portion 25, in particular the frame 28, has a piercing and / or cutting edge 32 or other splitting element 7. The piercing and / or cutting edge 32 is preferably attached to the frame 28, formed by the frame 28, in particular, formed integrally with the frame 28 and / or formed by molding on the frame 28. The piercing and / or cutting edge 32 is preferably formed by an at least substantially axially extending strip, preferably formed in one point.

[0429] The piercing and / or cutting edge 32 is preferably configured to open the second connection configuration 3B', in particular due to the perforation or piercing of the opening area 4B' of the second connection configuration 3B' by the piercing and / or cutting edge 32. Preferably, during the axial movement of the connection configurations 3A', 3B' relative to each other, the opening area 4B' of the second connection configuration 3B' is first pierced by the piercing and / or cutting edge 32 protruding axially outwards relative to the opening area 4A', in particular the opening area 4A' of the closure device 23, and only thereafter, the opening area 4A' of the first connection configuration 3A' can be opened by rotating the connection configurations 3A', 3B' relative to each other in the manner described. However, in contrast to Figures 5 to 13 Compared to the embodiment in , the retaining portion 25 or the mouth-shaped portion 5A' in this case is configured to pierce the opening area 4B' of the second connection arrangement 3B'. In this regard, reference is made to the previous explanations as supplementary information.

[0430] Compared to the previous embodiment, the piercing and / or cutting edge 32 in this embodiment is provided on the mouth-shaped portion 5A', which can also be like the previous embodiment and facilitates easier opening of the opening area 4B' of the second connection arrangement 3B'.

[0431] In the present embodiment, the opening region 4B' of the second connection arrangement 3B' is closed in particular by an at least substantially rigid, dimensionally stable and / or plate-shaped closure device 33, in particular a closure plate or a disk, which is preferably held sealingly on the mouth-shaped part 5B in particular by means of a weak point 34. Other configurations are also theoretically possible here, for example in combination with Figure 7 However, using the closing device 33 in a manner similar to the use of the closing device 23 to close the first connection arrangement 3A' makes it easier to open the opening area 4B' of the second connection arrangement 3B'.

[0432] The orientation and position of the piercing and / or cutting edge 32 preferably corresponds to the weak point 34 of the second connection arrangement 3B', so that bringing the connection arrangements 3A', 3B' together results in the application of the piercing and / or cutting edge 32 to the weak point 34, whereby the weak point 34 can be split starting from the initial point of application of the piercing and / or cutting edge 32. Preferably, the connection arrangements 3A', 3B' are correspondingly guided relative to each other.

[0433] The frame 28 and / or the piercing and / or cutting edge 32 preferably have rounded and / or chamfered portions, so that when the piercing and / or cutting edge 32 acts on the fragile point 34, the fragile point 34 is partially relieved, so that after opening, the intact portion of the fragile point 34 still makes the closure device 33 preferably close to the mouth-shaped part 5B', especially in the manner of a film hinge. This ensures that the closure device 33 is not disassembled and prevents blocking of one of the removal openings E1, E2.

[0434] In the embodiment shown, in the initial state, the closure means 33 is aligned with the mouth-shaped portion 5B' at least substantially perpendicular to the central axis or axis of symmetry 9. Of course, there can be an inclined alignment, like the closure means 23 of the first connection configuration 3A', but this is not absolutely necessary, since the second connection configuration 3B' is preferably opened mainly by the piercing and / or cutting edge 32 and not by deformation of the mouth-shaped portion 5B'.

[0435] The construction and retention of the mouth-shaped part 5B' are preferably sufficiently stable so that when the connection arrangements 3A', 3B' are rotated after being inserted into each other, the deformation occurs at least substantially or in any case mainly in the area of ​​the mouth-shaped part 5A' or the retaining part 25. However, a certain degree of deformation of the mouth-shaped part 5B' and / or the deformation device 30 of the second connection arrangement 3B' is feasible.

[0436] According to another aspect of the invention, the container B1, B2 (each) is formed from a container blank BR1, BR2 and a respective connection arrangement 3A', 3B'. The same also applies to the previous embodiments.

[0437] In the embodiment shown, the container blanks BR1, BR2 are upper container or bottle parts, which are configured for connection to the respective connection arrangements 3A', 3B' on one side or end remote from or opposite to the removal openings E1, E2. In particular, the container blanks BR1, BR2 are bottomless container blanks BR1, BR2, the resulting open area being closed by the respective connection arrangements 3A', 3B' during manufacture to form the respective container B1, B2.

[0438] In particular, therefore, the container blanks BR1 , BR2 have a structure with a removal opening E1 , E2 and a further open point which can be closed by a respective connection arrangement 3A′, 3B′.

[0439] Preferably, the respective connection arrangement 3A', 3B' is tightly connected to the wall of the container blank BR1, BR2 by material joining, in particular preferably by welding, adhesive bonding, injection molding or by some other method. Thus, the connection arrangement 3A', 3B can be used in various containers B1, B2 or can also be used independently of the container B1, B2 to (for example) fluidly connect the container B1, B2 to another structure such as a pipe, a connector or the like. However, it is preferred that the containers B1, B2, B3 are connected to each other.

[0440] Preferably, the (respective) connection arrangement 3A', 3B' is configured to be connected to the container blank BR1, BR2 to form the container B1, B2. In addition, preferably, the container blank BR1, BR2 should have walls 35A', 35B' and open edges 36A', 36B' to form a receptacle of the connection arrangement 3A', 3B', into which the respective connection arrangement 3A', 3B' can be inserted and tightly connected to the container blank BR1, BR2.

[0441] In another aspect, the present invention relates to a connection system 1, which has a first connection configuration 3A' including a retaining part 25 and a fragile point 24 and a second connection configuration 3B' including a deformation device 30 corresponding to the retaining part 25, wherein the connection configurations 3A', 3B' can be sealed and inserted into each other, and when the connection configurations 3A', 3B' are rotated relative to each other, the first connection configuration 3A' can be opened to produce a fluid connection 2 due to the deformation of the retaining part 25 by the deformation device 30.

[0442] In another aspect, which can also be implemented independently, the invention further relates to one or more containers B1, B2, B3, in particular bottles, which (each) have a connection configuration 3A', 3B' according to the invention, a further connection configuration 3A', 3B' or a base, preferably on a side or end away from a container opening or removal opening E1, E2.

[0443] In another aspect which can also be implemented independently, the invention further relates to a container system B having at least two containers B1, B2, B3, wherein the first container B1 comprises a first connection configuration 3A' and the second containers B2, B3 comprise a second connection configuration 3B' corresponding to the first connection configuration 3A'.

[0444] The connection arrangements 3A', 3B' are preferably configured as described above. In particular, the first connection arrangement 3A' preferably has a piercing and / or cutting edge 32 by which the second connection arrangement 3B' can be opened.

[0445] Alternatively or additionally, the second connection arrangement 3B' comprises a mouth-shaped portion 5B' or a deformation means 30 for opening the first connection arrangement 3A' of the first container B1 by deformation of the retaining portion 25 or the mouth-shaped portion 5A'.

[0446] Furthermore, preferably, the connection arrangements 3A′, 3B′ should be able to form a fluid connection 2 by opening to each other, the first connection arrangement 3A′ opening the second connection arrangement 3B′ and the second connection arrangement 3B′ opening the first connection arrangement 3A′ to thereby form the fluid connection 2 .

[0447] In another aspect of the invention which can also be implemented independently, the connection configurations 3A', 3B' are used to prepare mixtures of substances, preferably drugs, in particular vaccines or combination vaccines, to produce fluid connections 2 and / or to mix starting materials or substances S1, S2 which have been stored separately.

[0448] The invention further relates to a method for producing one of the connection arrangements 3A', 3B' or the connection system 1 and / or the container B1, B2, B3, which can also be implemented independently, wherein the closure 23, 33, the fragile point 24, 34 and the retaining part 25 or the mouth-shaped part 5A', 5B' are injection molded in a common step. This has proven to be advantageous for the reliable production of the fragile point 24, 34.

[0449] Furthermore, in the method, in a container blank BR1, BR2 having an open end, in particular a bottle blank having a removal opening E1, E2 and an open end, the open end is preferably sealed by a separately produced connection arrangement 3A', 3B'.

[0450] The connection configuration 3A', 3B' preferably comprises a set of annular and / or tubular portions 37A', 37B' which delimit the (respective) connection configuration 3A', 3B' radially outward and corresponding to the wall 35A', 35B' of the respective container B1, B2 or container blank BR1, BR2 for insertion therein and connection to the container blank BR1, BR2.

[0451] Another aspect of the invention, which can also be implemented independently, relates to a sealing concept based on connection arrangements 3A′, 3B′ in combination with one another or one of the connection arrangements 3A′, 3B′ in combination with one of the preferably cap-shaped cover devices 6 , 26 .

[0452] It can be provided that a container B1, B2, B3 has a connection arrangement 3A', 3B' for producing a fluid connection arrangement 2 of the container B1, B2, B3 with another container B1, B2, B3. In the initial state, the connection arrangement 3A', 3B' can be fluid-tight in the opening area 4A', 4B' and can be opened to form the fluid connection 2. The opening area 4A', 4B' is covered by a cap-shaped cover device 6, 26 and / or a further connection arrangement 3A', 3B'. Therefore, this aspect particularly relates to an individual container B1, B2, B3 of the container system B or its connection arrangement in combination with a cap-shaped cover 6, 26 and / or a (corresponding) connection arrangement 3A', 3B'.

[0453] In another aspect, which can also be implemented independently, it is conceivable that the cover device 6, 26 or other connection arrangement 3A', 3B' is kept sealingly on the proposed container B1, B2, B3 to thereby form a sealed chamber 38A, 38B, 38C. Moreover, the proposed container B1, B2, B3 comprises a sealing arrangement 39 surrounding its opening area 4A', 4B', which seals the volume 40A, 40B, 40C of the chamber 38A, 38B, 38C in direct contact with the opening area 4A', 4B'. Preferably, the sealing arrangement 39 isolates the inner volume 40A, 40B, 40C from the outer volume 41A, 41B, 41C of the chamber 38A, 38B, 38C. This advantageously covers the opening area 4A', 4B' in particular by double closure. This enhances the barrier against the entry of substances, in particular germs.

[0454] In particular, it can be provided that foreign matter can only reach the inner volume 40A, 40B, 40C by passing through the outer volume 41A, 41B, 41C. The sealing arrangement 39 is preferably mechanically separated from the environment by an outer seal of one of the cover devices 6, 26, so that any force acting on the cover device 6, 26 can affect the tight seal of the outer volume 41A, 41B, 41C, but even in this case, the inner volume 40A, 40B, 40C will remain sealed, preferably in an airtight manner, in particular in an antibacterial or antimicrobial manner. In this way, a sterile environment at the opening area 4A', 4B' can be guaranteed.

[0455] Alternatively or in addition, when the cover device 6, 26 or other connection arrangement 3A', 3B' is continuously moved relative to the connection arrangement 3A', 3B' of the proposed container B1, B2, B3, the sealing arrangement 39 seals the inner volume 40A, 40B, 40C surrounding the opening area 4A', 4B' by the cover device 6, 26 or other connection arrangement 3A', 3B'. In this way, during the process of inserting the connection arrangements 3A', 3B' into each other and / or during the assembly or removal of the cover device 6, 26, the opening area 4A', 4B' can be prevented from entering foreign matter, in particular, germs.

[0456] Preferably, both aspects are combined, i.e., a chamber 38A, 38B, 38C is formed which is divided by a sealing arrangement 39 into an internal volume 40A, 40B, 40C and an external volume 41A, 41B, 41C, the sealing arrangement 39 being configured to prevent foreign matter, in particular, pathogens, from entering the internal volume 40A, 40B, 40C, especially during axial movement of the cover device 6, 26 or other connecting arrangements 3A', 3B'.

[0457] The sealing configuration 39 preferably includes sealing parts 42A, 42B, 43A, 43B corresponding to each other, the first sealing parts 42A, 42B are associated with the connection configurations 3A', 3B' and the second sealing parts 43A, 43B are arranged on the cover device 6, 26 and / or another connection configuration 3A', 3B', in particular, are integrated with the cover device 6, 26 and / or another connection configuration 3A', 3B'.

[0458] The sealing parts 42A, 42B, 43A, 43B preferably include sealing surfaces 44A, 44B, 45A, 45B corresponding to each other. When the cover devices 6, 26 are placed on the connecting configurations 3A', 3B' or the connecting configurations 3A', 3B' are matched with each other, the sealing surfaces 44A, 44B, 45A, 45B are tightly connected to each other.

[0459] The sealing surfaces 44A, 44B, 45A, 45B preferably have similar cross-sectional shapes (perpendicular to the central axis or axis of symmetry 9 ) and / or are circular and / or rotationally symmetrical about a common axis of symmetry and / or central axis 9 .

[0460] Preferably, the sealing portions 44A, 44B, 45A, 45B are configured and / or correspond to each other such that the cover arrangement 6, 26 and / or other connection arrangement 3A', 3B' can be rotated relative to the container B1, B2, B3.

[0461] Preferably, one of the connection configurations 3A', 3B' includes sealing surfaces 44A, 44B, which correspond to the two sealing surfaces 44A, 44B of the other connection configuration 3A', 3B' and the sealing surfaces 45A, 45B of the cover device 6, 26 corresponding to the connection configuration 3A', 3B'. Therefore, the sealing configuration 39 can be formed together with the corresponding cover device 6, 26 and the other connection configuration 3A', 3B' based on the connection configuration 3A', 3B'. In this way, the same component can be used or the same component can be reused to achieve the sealing on the cover device 6, 26 during transportation and the sealing on the other connection configuration 3A', 3B' during use.

[0462] Another aspect of the present invention, which can also be implemented independently, relates to a connection system 1 and / or a container B3 for producing a fluid connection 2 between containers B1, B2, and B3, the connection system 1 or the container B3 having at least two connection configurations 3A', 3B' configured to produce a fluid connection 2, i.e., a first connection configuration 3A' and a second connection configuration 3B', which in an initial state respectively fluid-tightly or fluidly close the containers B1, B2, and B3 and can be opened in opening areas 4A', 4B' to produce a fluid connection 2.

[0463] In another aspect, provision can be made that the connection arrangement 3A', 3B' forms a sealed chamber 38C and comprises a sealing arrangement 39, while a volume 40C in direct contact with the opening area 4A', 4B' is isolated from a volume 41C of the chamber 38C separated from the opening area 4A', 4B' by the sealing arrangement 39.

[0464] Alternatively or additionally, the connection system 1 comprises a sealing arrangement 39 which uninterruptedly seals the volume 40C in direct contact with the opening areas 4A', 4B' when the connection arrangements 3A', 3B' are moved relative to each other.

[0465] Furthermore, preferably, the connection arrangements 3A', 3B' comprise at least two positions connected to one another, which are occupied successively in time and position when the connection arrangements 3A', 3B' are pushed into one another or engage one another. In a first connection position, a non-releasable connection between the connection arrangements 3A', 3B' is formed, and in a second connection position, only a fluid connection 2 is produced or can be produced. For further details, reference may be made to the previous embodiments.

[0466] Preferably, the sealing arrangement 39 uninterruptedly seals or closes the interior volume 40C and / or uninterruptedly isolates or separates the interior volume 40C from the exterior volume 41C in the first connection position, in the second connection position, and between the first connection position and the second connection position.

[0467] For further details on the connection system 1 in combination with the sealing arrangement 39, reference is made to the previous discussion, in particular, with regard to the connection system 1 in combination with, for example, Fig.16 , Fig.17 and Fig. 20 And / or in conjunction with the previous discussion of the sterile or sterilizable closures of the proposed containers B1 , B2 , B3 with the sealing arrangement 39 .

[0468] Another aspect of the invention, which can also be implemented independently, relates to a connection arrangement 3A', 3B' and / or a container B1, B2, B3 having such a connection arrangement 3A', 3B', wherein the opening area 4A', 4B' of the connection arrangement 3A', 3B' is fluidically closed in the initial state and can be opened to form the fluid connection 2. In this aspect, the connection arrangement 3A', 3B' comprises a cover device 6, 26, which can preferably be latched to the container B1, B2, B3 or the connection arrangement 3A', 3B' and / or is in the form of a cap and / or is removable and covers the opening area 4A', 4B'.

[0469] The cover device 6, 26 according to this aspect preferably includes a support portion 46, which corresponds to the opening area 4A', 4B' and is directly or closely adjacent to the opening area 4A', 4B', so that the force FS acting on the opening area 4A', 4B' in the direction of the support portion 46 is absorbed by the opening area 4A', 4B' at least partially contacting the support portion 46 to prevent the opening area 4A', 4B' from opening.

[0470] In accordance with Fig.23 In the embodiment of the embodiment, the cover device 26 closes the connection configuration 3A' in a corresponding manner. The support portion 46A is configured here to be directly adjacent to the closure device 23. When the force FS acts on the closure device 23 from the inside of the container B1, for example, when the container B1 suddenly opens the area of ​​the cover device 26 when it is inverted or the like and the substance S1 present in the container thus suddenly applies the force FS to the opening area 4A', in particular, the closure device 23, the closure device 23 can be supported by the support portion 46A, while in any case, the force FS is partially absorbed, captured and / or transferred by the support portion 46A. In this way, the opening area 4A' is prevented from being accidentally opened, in particular, the opening area 4A' is prevented from being accidentally opened due to impact or inversion.

[0471] refer to Fig. 27 , a corresponding mechanism for preferential operation by the support portion 46B of the cover device 6 combined with the opening area 4B' or the closure device 33. In addition, the prevention of opening provided by the support portions 46A, 46B (as described) can also be applied to the previous embodiments and aspects by using the cover devices 6, 26 with support portions 46A, 46B to replace the cover devices 6 or the closure 14 respectively.

[0472] The support portion 46 preferably at least substantially holds or can hold on the wall of the container B1, B2, B3 and / or the connecting arrangement 3A', 3B'. In this way, a force FS introduced into the support portion 46A, 46B can be transferred. Preferably, the support portion 46A is at least substantially rigidly connected to the mouth-shaped portion 5A', 5B' or the holding portion 25 by the connecting arrangement 3A', 3B' and / or the container B1, B2, B3, by its construction, or by mechanical means.

[0473] Thus, the opening area 4A', 4B' is preferably held on the wall of the container B1, B2, B3 or containers B1, B2, B3 via the mouth-shaped portion 5A' or the holding portion 25 and the support portion 46A, 46B is at least substantially rigidly held on the same container B1, B2, B3 or containers B1, B2, B3 on the same wall. Thus, a force FS directed outwardly to the opening area 4A', 4B' or the closure device 23, 33 in the direction of the support portion 46A, 46B or relative to the container volume can be absorbed and transferred by the support portion 46A, 46B. Thus, the force FS does not have to be transferred through or via the fragile point 24, 34 or is not transferred only through or via the fragile point 24, 34. An accidental opening of the respective connection arrangement 3A', 3B' is prevented by removing the load from the fragile point 24, 34 when any force FS is applied.

[0474] The support portions 46A, 46B preferably correspond to the closure means of the respective opening area 4A', 4B', in particular the respective closure means 23, 33, and / or are arranged adjacent to the closure means of the respective opening area 4A', 4B'. The support portions 46A, 46B may form a platform, which is arranged and / or aligned to be at least substantially parallel to and / or to correspond to one side of the closure means 23, 33 facing the support portions 46A, 46B. Furthermore, preferably, the movement of the closure means 23, 33 towards the support portions 46A, 46B results in a flat contact and / or a contact that counteracts the tilting of the closure means, in particular in combination with a force exerted on the closure means by an impact or a reversal.

[0475] The support portion 46A, 46B is preferably formed by the recess 47 of the cover device 6, 26 or the base of the container 13, which can be accessed from the outside when the cover device 6, 26 is installed or connected to the container B1, B2, B3 or the connection configuration 3A', 3B'. Regarding the container 13, reference is also made to the description of the previous embodiment as supplementary information. In particular, it is conceivable that the container 6, the recess 26 or the recess corresponds to the removal opening E1, E2 or the bottleneck F1, F2 of the container B1, B2, B3, so that the removal opening E1, E2 or the bottleneck F1, F2 of the container B1, B2, B3 can be accommodated in the container 6, the recess 26 or the recess, especially during transportation and / or as a supporting base.

[0476] The cover device 6 preferably includes a rib-shaped reinforcing element 48 that preferably helps to support the support portion 46B or stabilize the support portion 46B. Alternatively or in addition, the reinforcing element 48 corresponds to the bottleneck portion F1, F2 so as to accommodate, maintain and / or stabilize the bottleneck portion F1, F2. Even if the reinforcing element 48 is not provided in this embodiment, the cover device 26 may also include a corresponding or similar reinforcing element 48 in principle.

[0477] Preferably, the support portions 46A, 46B are supported by an inclined surface or at least substantially conical strip 49 to resist movement or deformation in the axial direction or along the central axis or in a direction parallel to the central axis and / or the axis of symmetry 9.

[0478] In addition, preferably, cover device 6,26 is sealed to container and / or connection configuration 3A ', 3B ' by sealing arrangement 39. Sealing device 39 preferably closes one side of support portion 46A, 46B facing opening area 4A ', 4B '. Alternatively or in addition, sealing arrangement 39 is also provided on the wall of provided container B1, B2, B3 except sealing and / or latch installation cover device 6,26. In this way, chamber 38A, 38B, internal volume 40A, 40B and / or volume 40A, 40B, 41A, 41B separated from each other can be formed in cover device 6,26 attached to or can be attached to container B1, B2, B3 or connection configuration 3A ', 3B '.

[0479] In another aspect that can also be implemented independently, the present invention further relates to a cap-shaped cover device 6, 26 itself and / or its combination with one of a connection configuration 3A', 3B' to form a fluid connection 2, in particular, a fluid connection 2 between containers B1, B2, B3, the cover device 6, 26 having a side wall 50A, 50B and a base 51A, 51B adjacent to the side wall 50A, 50B.

[0480] Retaining means for releasably retaining the cover means 6, 26 by interlocking and / or frictional engagement are provided on the side walls 50A, 50B. In particular, this is in the form of beads or by one or more areas of some other components, which are configured to seal and / or otherwise attach one or more (preferably one) surrounding connections to the container B1, B2, B3 by interlocking and / or frictional engagement, in particular, to seal and / or otherwise attach one or more surrounding connections to the container B1, B2, B3 uninterruptedly.

[0481] Preferably, the base 50 comprises a receiving groove 13, a notch 47 or a recess into which the bottleneck-shaped removal opening E1, E2 of the container B1, B2, B3 can be inserted.

[0482] Alternatively or additionally, the base area of ​​the receptacle 13, recess 47 or recess leading to the opening of the cover device 6, 26 comprises a platform-like supporting portion 46A, 46B for supporting the opening area 4A', 4B' of the connection arrangement 3A', 3B', the container B1, B2, B3 or a part thereof.

[0483] Alternatively or in addition, the base 51A, 51B of the cover device 6, 26 includes a surrounding strip sealing portion 43A, 43B, which is configured to form a plurality of enclosed volumes 40A, 40B, 40C, 41A, 41B, 41C and / or subdivided chambers 38A, 38B and / or a supporting base 51A, 51B.

[0484] The support portions 46A, 46B are preferably supported or reinforced, in particular by rib-like reinforcing elements 48, preferably such that the cover device 6, 26 is hardened for transferring the force FS acting on the support portions 46A, 46B into the wall of the container B1, B2, B3.

[0485] In another aspect that can also be implemented independently, the present invention relates to the use of a cap-shaped cover device 6, 26 including a support portion 46A, 46B, the cover device 6, 26 being configured to be directly adjacent to the opening area 4A', 4B' of the container B1, B2, B3 or to be separated from the opening area 4A', 4B' of the container B1, B2, B3 by a small interval, so that the force FS acting on the opening area 4A', 4B' in the direction of the support portion 46A, 46B is absorbed by the flat contact of at least part of the opening area 4A', 4B' with the support portion 46A, 46B to prevent accidental opening under the action of external forces (preferably acceleration forces), in particular, accidental opening due to impact or inversion of the container B1, B2, B3 connected or connectable to the cover device 6, 26 and / or the connection configuration 3A', 3B' provided to the container B1, B2, B3 or forming a part thereof.

[0486] refer to Figure 31 to Figure 34 , we will explain again how the containers B1, B2, and B3 are connected by (for example) Fig.26 and Fig.30 The first connection arrangement 3A' and the second connection arrangement 3B' shown in FIG. 3 are connected to each other to form a fluid connection 2. The process at least substantially corresponds to the combined Figures 5 to 13 procedures described, or vice versa.

[0487] Preferably, the cover means 6, 26 are first removed to thereby expose the connection arrangements 3A', 3B'. The cover means 6 may act as a support.

[0488] Next, the connection arrangements 3A', 3B' are brought axially close to each other and inserted into each other, e.g. Figure 31 to Figure 33 As shown in .

[0489] Depending on the situation, arrival Fig.32 As a first connection position, the preliminary latching stage shown in FIG. 1 is a first connection position, in which the connection arrangement 3A', 3B' or its opening area 4A', 4B' is still closed or remains closed, but the connection arrangement 3A', 3B' or the container B1, B2, B3 is already held on each other, in particular by an interlocking engagement, in particular a non-releasable interlocking engagement. For details of this, reference is made to the corresponding explanations of the previous embodiments.

[0490] Fig.33 It is shown how the first connection configuration 3A opens the opening region 4B' of the second connection configuration 3B', in which case preferably a piercing and / or cutting edge 32 or some other splitting element 7 is used. To this end, the piercing and / or cutting edge 32 is applied axially to the fragile point 34 of the retaining closure device 33. As the movement continues, the fragile point 34 is split, in particular, the fragile point 34 is cut or torn by the piercing and / or cutting edge 32. Thus, the opening region 4B' of the second connection configuration 3B' is first opened.

[0491] In the following step, the connection arrangements 3A', 3B' or the containers B1, B2, B3 are rotated relative to each other about the common center axis or axis of symmetry 9, thereby deforming the retaining portion 25 or the mouth-shaped portion 5A' of the first connection arrangement 3A' and thus also opening the opening area 4A' of the first connection arrangement 3A', such as in the final open position. Fig. 22 and Fig.34 As shown in .

[0492] The connecting arrangements 3A', 3B' can preferably be connected to each other by a bayonet action, wherein, after the connecting arrangements 3A', 3B' have been pushed into each other, at least substantially or purely axial movement along the center axis or axis of symmetry 9 is supplemented by a rotational movement of the connecting arrangements 3A', 3B' relative to each other around the center axis or axis of symmetry 9.

[0493] This bayonet movement is preferably guided by the connection arrangement 3A', 3B'. In particular, as (for example) Fig.26 The first connection configuration 3A' and Fig.30 As can be seen in the perspective view of the second connection configuration 3B' in FIG, corresponding guide means or guides 18A, 18B are provided, which preferably guide the bayonet-type movement described above. In particular, the first connection configuration comprises a strip-shaped guide means or guide 18A, which preferably extends at least substantially in a plane perpendicular to the center axis or axis of symmetry 9 or at least substantially along a plane perpendicular to the center axis or axis of symmetry 9. The guide means or guide 18B of the second connection configuration 3B' preferably has a corresponding, preferably complementary construction. The guide means or guide 18B may comprise a guide groove in which the corresponding guide means or guide 18A can be guided.

[0494] The guide means or guides 18A, 18B may also be configured to predefine an alignment around the central axis or axis of symmetry 9 when the connection arrangements 3A', 3B' are brought closer to each other. This alignment is preferably selected so that the opening areas 4A', 4B' (which are, for example, elliptical in the embodiment shown) correspond to each other or are positioned in a similar orientation to each other.

[0495] The guide means or guides 18A, 18B are preferably configured to prevent the connection arrangements 3A', 3B' from rotating about the central axis or axis of symmetry 9 by means of an interlocking engagement when the connection arrangements 3A', 3B' are moved towards each other. Once the connection arrangements 3A', 3B' have been inserted into each other, in particular to thereby open the opening area 4B' of the second connection arrangement 3B', the guide means 18A, 18B enable the connection arrangements 3A', 3B' to be moved in rotation relative to each other about the common central axis or axis of symmetry 9. This rotation results in the above-mentioned deformation of the mouth-shaped portion 5A' or the retaining portion 25 of the first connection arrangement 3A' and thus in the opening of the opening area 4A of the first connection arrangement 3A to thus form the fluid connection 2.

[0496] The guiding device or guide 18A, 18B is also preferably embodied to block the relative position of the connecting configurations 3A', 3B' in the axial direction (i.e. in the direction of the center axis or symmetry axis 9), in particular by interlocking engagement, by the connecting configurations 3A', 3B' rotating relative to each other, or after the connecting configurations 3A', 3B' are rotated relative to each other.

[0497] Alternatively or additionally, securing means can be provided which prevent reverse rotation. This ensures that after the fluid connection 2 has been produced, the connection arrangements 3A′, 3B′ cannot be separated again in order in particular to ensure the sterility of the fluid connection 2 .

[0498] In another aspect, which can also be implemented independently, the present invention relates to a container system B having two containers B1, B2, B3, B4, which are fluidly separated from each other in an initial state and can be fluidly connected to each other by moving the containers B1, B2, B3, B4 relative to each other, while in the initial state, the fixing device 52 in particular prevents partial and / or initial axial movement of the containers B1, B2, B3, B4 or their connection configurations 3A', 3B' relative to each other.

[0499] exist Fig.35 In the embodiment shown, the figure shows, for example, a first container B1 and a further container B4 and a fixing device 52. In the embodiment shown, the further container B4 has only one possible inlet formed by the second opening device 4B'. However, other solutions are also possible, for example, using the containers B2 and B3 described above.

[0500] Fig.35The fixture 52 is shown in an initial state, wherein the containers B1, B4 are not connected to each other. In this initial state, the fixture 52 prevents the containers B1, B4 from moving relative to each other to open or create a connection between the containers B1, B4 as required. In this example, the fixture 52 supports the containers B1, B4 from each other to thereby prevent the containers from moving axially toward each other.

[0501] Fig.36 Display from according to Fig.35 , wherein the fixing device 52 has been activated or actuated. In this state, the containers B1, B4 are free to move relative to each other so that the fluid connection 2 can be formed. To this end, preferably, the opening areas 4A, 4B, 4A', 4B' are opened based on the connection configurations 3A, 3A', 3B, 3B' described above by initially axially or temporarily and then rotationally moving the containers B1, B4 relative to one of each other.

[0502] Fig.37 Display the state after the relative movement has occurred according to Fig.35 An enlarged detail of an embodiment.

[0503] Fig.38 A perspective view of the fixing device 52 is shown.

[0504] In this respect, the containers B1 , B4 can preferably be connected to one another by means of the proposed connection arrangements 3A′, 3B′. However, other connection methods are also conceivable in principle.

[0505] The container system B preferably comprises a receptacle 53 for the fixing device 52 , in particular a pocket, into which the fixing device 52 can be received, in particular by pushing the fixing device 52 in, as a result of or during the relative movement.

[0506] In particular, in the embodiment shown, the connection arrangements 3A′, 3B′ are axially moved relative to each other to open the second connection arrangement 3B′. This relative axial movement is prevented by the fixing device 52 in the initial state and can be permitted by the fixing device 52 .

[0507] The receptacle 53 is preferably provided behind a wall 35A', 36A' of one of the containers B1, B4 and / or behind a collar-shaped and / or tubular portion 37A', 37B' of one of the connection arrangements 3A', 3B', viewed from the outside. In the embodiment shown, this wall is a wall of the container B1, which preferably forms a tubular or collar-shaped extension of the wall of the container B1 delimiting an internal chamber, more particularly aligned with the internal chamber.

[0508] In the embodiment shown, the groove 53 is formed between the wall 35A', 36A' or the collar-like portion 37A, 37B and the mouth-shaped portion 5A', 5B' or the opening area 4A', 4B' of the container B1. However, alternatively or additionally, this may also be applicable to other containers B2, B3, B4.

[0509] The container system B is preferably configured such that during, due to or after actuation, the fixing device 52 can protrude into the receptacle 53 in an axial direction based on the central axis and / or the axis of symmetry 9 of the container system B or be aligned with the receptacle 53 .

[0510] In addition, preferably, the fixing device 52 is configured in the starting position between the edges 36A', 36B' of the containers B1, B2, B3, B4 or the connecting configurations 3A', 3B', in particular, the edges 36A', 36B' are opposite to or correspond to each other, so that the edges 36A', 36B' are supported on each other by the fixing device 52.

[0511] The fixing device 52 is preferably at least partially deformable, thereby allowing relative movement. In particular, it can be provided that the interlocking engagement can be released by actuating the fixing device 52, so that the containers B1, B2, B3, B4 are no longer supported on each other to thereby allow relative movement to occur.

[0512] In the embodiment shown, the fixing device 52 is annular or ring-shaped, in particular, is formed by a ring, in particular a fixing ring, or comprises a fixing ring that is at least partially deformable or deformable in certain areas to release the connection. However, this is not essential and can also be achieved by some other method, but the use of a ring has advantages from the point of view of manufacturing and assembly.

[0513] The fixing device 52 preferably comprises or is formed by at least one blocking member 54, preferably in the shape of a fin or wing. In the starting position, the blocking member 54 prevents the connection configurations 3A', 3B' from moving relative to each other by interlocking engagement. Moreover, the blocking member 54 is preferably deformable or depressible so as to release the blockage and allow relative movement.

[0514] In the embodiment shown, one or several blocking members 54 include an edge 55, which forms an interlocking engagement and is movable, preferably deformable, at least substantially in a radial direction (relative to the central axis or axis of symmetry 9 or in the direction of the central axis or axis of symmetry 9) to release the blockage. In particular, the blocking member 54 is molded on one end of the fixing device 52, is formed integrally with the fixing device 52, and / or has a wing-shaped configuration.

[0515] The housing 53 preferably corresponds to the shape of the fixing device 52 or vice versa and can therefore comprise or be formed by a cavity or a recess, in particular also in the form of an annular or ring-shaped structure complementary to the fixing device 52. This cavity or recess preferably comprises an opening towards the fixing device 52 or towards the connection arrangement 3A', 3B' relative to the housing 53.

[0516] The fixing device 52 is preferably formed of plastic, in particular a thermoplastic material. Thus, the fixing device 52 can be a plastic ring. The blocking member 54 is preferably elastically deformable. Alternatively, the release can also be affected by the plastic deformation of the blocking member 54.

[0517] In the initial state, the fixing device 52 is preferably arranged between the containers B1, B2, B3, and B4 in such a manner that relative movement in the axial direction relative to the center axis and / or the axis of symmetry 9 of the container system B is prevented and the relative movement can be released by radial partial deformation of the fixing device 52 in the direction of the center axis and / or the axis of symmetry 9 of the container system B.

[0518] The fixing device 52 is preferably not able to be stripped and / or removed. On the contrary, the fixing device 52 is received in the receptacle 53 during or after actuation and therefore advantageously does not result in a separate part that must be handled separately to thereby improve handling and operational reliability.

[0519] In the embodiment shown, the fixing device 52 is rotatable, in particular, is mounted rotatably about the center axis and / or the axis of symmetry 9. The fixing device 52 is held on the tapered portion and / or on the container system B by means of an interlocking engagement.

[0520] In another aspect, which can also be implemented independently, the present invention relates to a method for preparing a mixture of substances, in particular a vaccine, wherein starting substances in the form of a first substance S1 and a second substance S2 are provided separately from each other in two fluidically connected containers B1, B2, B3, B4 and the containers B1, B2, B3, B4 can be fluidically connected by moving relative to each other, preferably axially relative to a central axis and / or an axis of symmetry of the container system B.

[0521] Preferably, during the procedure, a groove 53 is provided and a fixture 52 is configured or formed between the containers B1, B2, B3, B4 to prevent the containers B1, B2, B3, B4 from moving relative to each other in the initial state. In the procedure, the fixture 52 is actuated and pushed into the groove 53 due to actuation and / or relative movement.

[0522] For example, in the embodiment shown, the fixing device 52 is disposed between the first container B1 and the fourth container B4. However, these containers can theoretically be replaced by other types of containers, especially as described above. Therefore, during the formation of the container 53, the fixing device 52 can theoretically also be arranged in the same manner as according to Figures 22 to 33 The embodiment of the invention is used according to Fig.32 in the first connection position.

[0523] Fig.37 An enlarged detail of the area of ​​the fixture 52 and the receptacle 53 is shown, in which the relative movement has taken place. Thus, the fixture 52 or one or more blocking members 54 have each been partially or at least substantially pushed into the receptacle 53. In particular, the edge 55 has been pushed into the receptacle 53. Preferably, this prevents the fixture 52 from entering into another interlocking engagement. In the embodiment shown, the fixture 52 is arranged between the tubular or skirt-shaped extension of the wall 35A' of the first container B1 in the receptacle 53 and the first connection arrangement 3A'.

[0524] Fig.38 A schematic perspective view of the proposed fixing device 52 itself is shown. This figure clearly shows the wing-shaped blocking element 54 which is formed in the manner of a film hinge or is hinged to the fixing device 52 by a film hinge-like connection. Fig.39 In the embodiment shown, the pivot axis of the blocking member 54 lies at least substantially in the plane formed by the fixing device 52 .

[0525] Fig.39 A schematic cross section through a container system B with a fixing device 52 according to a second embodiment is shown. The second embodiment is functionally similar to the first embodiment and reference is therefore made to the description of the Figures 35 to 38 Therefore, only the differences from the previous embodiment will be explained below.

[0526] Fig.39 The container system B or the fixing device 52 is shown in a starting or blocking position. In this position, the blocking member 54 acts between the containers B1 , B4 so that the containers B1 , B4 are supported on each other and in this way prevented from relative movement.

[0527] Fig.40 The container system B with the actuated fixing device 52 is shown, while a relative movement is achieved. To this end, one or several blocking members 54 are deformed or displaced so that the blocking member 54 or the fixing device 52 can be accommodated in the receiving groove 53, in particular by pushing them into the receiving groove 53.

[0528] Fig.41The container system B or a part thereof is shown during or after a relative movement, during or as a result of which the fixing device 52 has been pushed into the receiving groove 53 .

[0529] Fig.42 A perspective view of the fixture 52 of the second embodiment is shown. One or more blocking members 54 have a wing-shaped configuration. The blocking member 54 in the initial state at least substantially protrudes tangentially along a circumference of the fixture 52 or the container B1, B4. In other words, the blocking member 54 can be bent around one or more axes extending at least substantially parallel to the central axis or axis of symmetry 9 and / or can be deformed by winding it into a shape corresponding to the receptacle 53 or a shape that allows relative movement.

[0530] The purpose of both embodiments is to achieve unlocking by forming the blocking member 54 into a shape and / or bringing the blocking member 54 into a position in which the fixing device 52 corresponds to the groove 53 and can move relative to it, so that the fixing device 52 can be pushed into the groove 53 due to the relative movement or during the relative movement.

[0531] In accordance with Figures 35 to 42 In the embodiment of the present invention, the fixing device 52 is realized as a different part separated from the connection arrangement 3A, 3A', 3B, 3B' and / or the container B1, B2. Thereby, the fixing device 52 can be arranged between the connection arrangement 3A, 3A', 3B, 3B' or the container B1, B4 as needed during assembly.

[0532] Alternatively or additionally, the fixing arrangement 52 may be formed by the container B1 , B4 and / or the connecting arrangement 3A, 3A', 3B, 3B' or may be connected in a fixed and / or permanent manner to the container B1 , B4 and / or the connecting arrangement 3A, 3A', 3B, 3B'.

[0533] In this case, the receptacle 53 and the fixing device 52, in particular one or more blocking elements 54, are preferably provided opposite each other at different containers B1, B4 or connection arrangements 3A, 3A', 3B, 3B'. By this measure, the fixing device 52 and / or one or more blocking elements 54 can be displaced into the receptacle 53 during or after the actuation of the fixing device 52.

[0534] The fixing device 52, in particular one or more blocking members 54, can be connected to the container B1, B4 or the connection arrangement 3A, 3A', 3B, 3B' by positive locking, friction connection and / or bonding or can be integrally formed with the container B1, B4 or the connection arrangement 3A, 3A', 3B, 3B'. Preferably, the fixing device 52 and / or the blocking member 54 are matched, injection molded and / or formed together with the container B1, B4 or the connection arrangement 3A, 3A', 3B, 3B' in a common production step, in particular by injection molding. However, the fixing device 52 can be retained at the container B1, B4 or the connection arrangement 3A, 3A', 3B, 3B' by a bayonet fit or by other measures.

[0535] The blocking element 54 is preferably held in a film hinge-like manner at the container B1, B4 or the connection arrangement 3A, 3A', 3B, 3B'. Alternatively or in addition, the blocking element 54 can be configured and / or fixed in a deformable manner. This also enables the blocking element 54 to be operated without a separately implemented fixing device 52. Here, the blocking element 54 can be similar to Fig.38 and / or Fig.42 may be configured as depicted in or configured in a different manner.

[0536] In another aspect, which can also be implemented independently, the present invention relates to a use for mixing viscous liquids, in particular connection arrangements and / or containers for vaccines, preferably, these viscous liquids are stable at 23° C. and 1 s -1 The viscosity specified above within the scope of the present invention can be determined in particular by the method according to EN ISO 2884-1:2006. In particular, the viscous liquid has the advantage that it has a larger hydraulic minimum connection cross section than the known solution.

[0537] Aspects of the invention can be combined with each other. In particular, Figures 1 to 20 The aspects of the embodiments of the present invention can also be used according to Figures 21 to 37 In embodiments of the present invention, and vice versa.

[0538] For example, aspects of the sealing arrangement 39 and / or the support portions 46A, 46B may also be present in Figures 1 to 20In the embodiment of the cover device 6 in the embodiment. The cover device 6, 26 can especially obtain a repeated or multi-stage sterile and / or sterilizable closure, while combining Fig.17 The explained aspects can be combined with Figures 22 to 34 The described aspects of the sealing arrangement 39 are combined. Alternatively or additionally, the aspects of the deformation-based opening (such as in combination with Figures 6 to 15 The embodiments of the present invention may be combined with the aspects of the closure device 33, or vice versa. These examples show that there are many preferred combinations of aspects that may form the subject matter of the present invention, even if the combination is not explicitly described.

[0539] More specifically, the present application provides the following:

[0540] 1. A connection system (1) for providing a fluid connection (2), preferably a connection system (1) for a fluid connection (2) between containers (B1, B2, B3), wherein the connection system (1) comprises at least two connection configurations (3A, 3B, 3A', 3B') configured for preparing the fluid connection (2), namely a first connection configuration (3A, 3A') and a second connection configuration (3B, 3B'), in an initial state, the at least two connection configurations (3A, 3B, 3A', 3B') are respectively fluid-tight,

[0541] Features:

[0542] The first connection configuration (3A, 3A') particularly has a film-like, brittle and / or unstable opening area (4A, 4A'), which can be deformed outside the opening area (4A, 4A') and is configured so that the deformation causes the first connection configuration (3A, 3A') to open in the opening area (4A, 4A').

[0543] 2. A connection system according to claim 1, wherein the opening is caused by at least substantially radial tensioning and / or stretching the opening region (4A, 4A'); and / or

[0544] The second connection configuration (3B, 3B') is configured to open the first connection configuration (3A, 3A'), wherein preferably, the second connection configuration (3B, 3B') is configured to open the opening area (4A, 4A') of the first connection configuration (3A, 3A') by deforming the first connection configuration (3A, 3A').

[0545] 3. A connection system according to item 1 or 2, wherein the deformation is produced and / or the opening area (4A, 4A') of the first connection configuration (3A, 3A') is opened by rotating these connection configurations (3A, 3B, 3A', 3B') relative to each other, in particular around a common axis (9).

[0546] 4. A connection system as in any of the preceding items, wherein the connection arrangements (3A, 3B, 3A', 3B') comprise mutually corresponding non-circular parts which implement the deformation and / or the opening when they are rotated relative to each other.

[0547] 5. A connection system as described in any of the preceding items, wherein the deformation causes tensioning of the opening area (4A, 4A'), the tensioning extending at least substantially radially or at right angles to the central axis or axis of symmetry (9) or along the opening area (4A, 4A'), thereby tearing, breaking or disassembling the opening area (4A, 4A') and / or leaving the opening area (4A, 4A') open.

[0548] 6. A connection system as described in any of the preceding items, wherein the second connection configuration (3B, 3B') particularly includes a film-like, brittle and / or unstable opening area (4B, 4B'), wherein preferably, the first connection configuration (3A, 3A') is configured to leave the second connection configuration (3B, 3B') open.

[0549] 7. A connection system according to item 6, wherein the first connection configuration (3A, 3A') is configured to open the second connection configuration (3B, 3B') by breaking through the opening area (4B, 4B') of the second connection configuration (3B, 3B').

[0550] 8. A connection system as in any of the preceding items, wherein the fluid connection (2) is produced by opening the two connection arrangements (3A, 3B, 3A', 3B') or their opening areas (4A, 4B, 4A', 4B'), preferably to one another.

[0551] 9. A connection system as described in any of the preceding items, wherein the first connection configuration (3A, 3A') includes a mouth-shaped portion (5A, 5A') adjacent to the opening area (4A, 4A') or surrounding the opening area (4A, 4A'), wherein the mouth-shaped portion (5A, 5A') is deformable so that the deformation enables the opening area (4A, 4A') to open.

[0552] 10. A connection system according to item 9, wherein the mouth-shaped part (5A, 5A') is mesh-shaped, neck-shaped, wall-shaped, thin-walled, elastic and / or flexible; and / or the mouth-shaped part (5A, 5A') is more elastic, flexible and / or stable than the opening area (4A, 4A'), preferably so that when the mouth-shaped part (5A, 5A') is deformed, the opening area (4A, 4A') is opened, especially by tearing, breaking or disassembling.

[0553] 11. A connection system according to item 9 or 10, wherein the second connection configuration (3B, 3B') is configured to deform the mouth-shaped portion (5A, 5A') of the first connection configuration (3A, 3A') so that the deformation causes the opening area (4A, 4A') of the first connection configuration (3A, 3A') to open.

[0554] 12. A connection system according to any one of items 9 to 11, wherein the mouth-shaped portion (5A, 5A') has a non-circular cross-section, in particular an elliptical and / or polygonal cross-section, and preferably, the second connection configuration (3B, 3B') has a corresponding cross-section, so that the rotation of these connection configurations (3A, 3B, 3A', 3B') relative to each other causes the deformation and / or the opening of the first connection configuration (3A, 3A') in its opening area (4A, 4A'); and / or

[0555] wherein the two connection arrangements (3A, 3B, 3A', 3B') have mouth-shaped parts (5A, 5B, 5A', 5B') which can be arranged on each other in a directional manner or pushed into each other, and preferably, the rotation of these connection arrangements (3A, 3B, 3A', 3B') or these mouth-shaped parts (5A, 5B, 5A', 5B') relative to each other causes the deformation of the first mouth-shaped part (5A, 5A') and preferably the second mouth-shaped part (5B, 5B'), and / or

[0556] The first connection configuration (3A') is configured according to any one of items 16 to 26.

[0557] 13. A method for providing a fluid connection between separate containers (B1, B2, B3), in particular bottles, wherein a first container (B1, B1') comprises a first connection configuration (3A, 3A') having a first opening area (4A, 4A'), and wherein, to provide the fluid connection (2), the first opening area (4A, 4A') is opened by deforming the first connection configuration outside the first opening area (4A, 4A'), thereby generating mechanical tension in the opening area (4A, 4A'), causing the opening area (4A, 4A') to tear.

[0558] 14. A container system (B) comprising at least two containers (B1, B2, B3), preferably bottles, and a connection system (1) according to any one of items 10 to 14, wherein these containers (B1, B2, B3) respectively include at least one connection configuration (3A, 3B, 3A', 3B'), and preferably, at least one of these containers (B1, B2) includes a removal opening (E1, E2) and / or these containers (B1, B2, B3) are configured to use these connection configurations (3A, 3B, 3A', 3B') to provide the fluid connection (2) between these containers (B1, B2, B3).

[0559] 15. Use of a container system (B) according to claim 14, wherein the first container (B1) comprises a first substance (S1), in particular, a first vaccine for preventing a first disease, wherein the second container (B2) comprises a second substance (S2), in particular, a second vaccine for preventing a second disease different from the first disease, wherein at least one of the containers (B1, B2) comprises a removal opening (E1, E2) and the containers (B1, B2) respectively comprise a connection configuration (3A, 3B, 3A', 3B') for providing a fluid connection between the containers (B1, B2), the container system (B) is used to prepare a mixture of substances, in particular, for preparing a combination vaccine for simultaneous immunization against different diseases, wherein the containers are fluidically connected to each other by means of the connection configurations (3A, 3B, 3A', 3B') so that the substances (S1, S2) are mixed to form in particular the combination vaccine.

[0560] 16. A connection arrangement (3A') for providing a fluid connection (2) between containers (B1, B2, B3), in particular for a connection system (1) according to any one of items 1 to 12 and / or for a container system (B) according to item 14, which is referred to as the first connection arrangement (3A') hereinafter, wherein the first connection arrangement (3A') preferably comprises a rigid closure device (23), in particular a closure plate, which in an initial state is sealingly held on a retaining portion (25) of the connection arrangement (3A, 3A') by a fragile point / line (24), in particular a fine point / line, and the fragile point / line (24) preferably forms an opening area (4A') or a part thereof,

[0561] Features:

[0562] The retaining portion (25) is movable by deformation relative to the closure device (23), whereby the first connection arrangement (3A, 3A') is opened by tearing the weak point / line (24).

[0563] 17. A connection configuration according to item 16, wherein the weak point / line (24) or the area bounded by the weak point / line (24), in particular the plane (27), is inclined relative to the central axis (9) of the first connection configuration (3A').

[0564] 18. A connection configuration according to item 16 or 17, wherein the first connection configuration (3A') and / or the closure device (23) are configured and / or wherein the closure device (23) is retained by the weak point / line (24) in such a manner that the closure device (23) is tilted during deformation of the retaining portion (25).

[0565] 19. A connection configuration according to any one of items 16 to 18, wherein the retaining portion (25) includes a frame (28), and in the initial state, the closing device (23) is tilted relative to the frame (28) so that in the offset area directly adjacent to the fragile point / line (24), the frame (28) is gradually offset relative to the closing device (23).

[0566] 20. A connection configuration according to item 19, wherein due to the gradual offset, during deformation, the closing device (23) protrudes behind the frame (28) and / or a shear movement of the closing device (23) occurs relative to the frame (28).

[0567] 21. A connection configuration according to any one of items 16 to 20, wherein the closure device (23) is configured to be in the shape of a slope starting from the weak point / line (24) provided at the edge, preferably so that the closure device (23) continues to tilt as the deformation progresses.

[0568] 22. A connection configuration according to any one of items 16 to 21, wherein the closure device (23) comprises a reinforcement (29), in particular, one or more ribs, wherein preferably, the reinforcement (29) is configured in the shape of a slope starting from the weak point / line (24) provided at the edge.

[0569] 23. A connection configuration according to any one of items 16 to 22, wherein the retaining portion (25) is non-circular and perpendicular to the central axis and / or the axis of symmetry (9), so that due to the insertion of the retaining portion (25) into a deformation device (30) of at least substantially complementary shape and the subsequent rotation of the retaining portion (25) around the central axis and / or the axis of symmetry (9) relative to the deformation device (30), the deformation of the retaining portion (25) preferably occurs radially relative to the central axis and / or the axis of symmetry (9) or in the direction of the central axis and / or the axis of symmetry (9).

[0570] 24. A connection configuration according to any one of items 16 to 23, wherein the retaining portion (25) is configured in the shape of a neck or a collar and / or is a pipe with flexible deformable walls and / or wherein the retaining portion (25) is or forms part of the mouth-shaped portion (5A').

[0571] 25. A connection configuration according to any one of items 16 to 24, wherein the retaining portion (25), in particular the frame (28), has a piercing and / or cutting edge.

[0572] 26. A connection configuration (3A', 3B'), in particular, a connection configuration according to any one of items 16 to 25, characterized in that: the connection configuration (3A', 3B') is configured to be connected to a container blank (BR1, BR2) to form a container (B1, B2), and preferably, the container blank (BR1, BR2) has an opening with a wall (35A', 35B'), and the connection configuration (3A', 3B') can be inserted into the opening and can be tightly connected to the container blank (BR1, BR2), in particular by welding, adhesive bonding or by some other method, preferably by material engagement.

[0573] 27. A connection system, in particular, a connection system according to any one of items 1 to 12, which has a first connection configuration (3A') according to any one of items 16 to 26 and a second connection configuration 3B') comprising a deformation device (30) corresponding to the retaining part (25), wherein these connection configurations (3A', 3B') can be sealed and inserted into each other and when these connection configurations (3A', 3B') are rotated relative to each other, due to the deformation of the retaining part (25), the first connection configuration (3A') can be opened to form the fluid connection (2).

[0574] 28. A container (B1, B2, B3), in particular a bottle, having a connection configuration (3A', 3B') according to any one of items 16 to 26, and preferably, the container (B1, B2, B3) includes the connection configuration (3A') on the side away from the extraction and / or removal opening (E1, E2).

[0575] 29. A container system (B), in particular, a container system according to item 14, having at least two containers (B1, B2, B3), wherein the first container (B1) has a connection configuration (3A') according to any one of items 16 to 26 and the second container (B2) has a second connection configuration (3B') corresponding to the first connection configuration (3A'), wherein preferably,

[0576] a) the first connection arrangement (3A') comprises splitting means (7), in particular a piercing and / or cutting edge (32), by means of which the second connection arrangement (3B') can be opened; and / or

[0577] b) the second connection arrangement (3B') comprises deformation means (30) for opening the first container (B1) by the first connection arrangement (3A') by deformation of the retaining portion (25); and / or

[0578] c) wherein these connection configurations (3A', 3B') can produce the fluid connection (2) by opening each other, the first connection configuration (3A') opening the second connection configuration (3B') and the second connection configuration (3B') opening the first connection configuration (3A'), so that the fluid connection (2) can be produced.

[0579] 30. Use of a connection configuration (3A') according to any one of items 16 to 26, a connection system according to item 27, a container (B1, B2, B3) according to item 28 and / or a container system (B) according to item 29, wherein the connection configuration (3A'), the connection system, the container (B1, B2, B3) and / or the container system (B) are used to prepare a mixture of substances, preferably a drug, in particular, a vaccine or a combination vaccine, by creating a fluid connection (2) and mixing substances (S1, S2) that have been stored separately.

[0580] 31. A method for producing a connection configuration (3A', 3B') according to any one of items 16 to 26, a connection system (1) according to item 27, a container (B1, B2, B3) according to item 28 and / or a container system (B) according to item 29, wherein the closing device (23, 33), the fragile point / line (24, 34) and the retaining portion (25) or the mouth-shaped portion (5B') are injection molded in a common step, preferably starting from the closing device (23, 33).

[0581] 32. A method according to claim 31, wherein in a container blank (BR1, BR2) having an open side, in particular in a bottle blank having an extraction and / or removal opening (E1, E2) in addition to the open side, the open side is closed by the connection configuration (3A', 3B').

[0582] Explanation of symbols

[0583] 1 Connecting the system

[0584] 2 Fluid connections

[0585] 3A, 3A' First connection configuration

[0586] 3B, 3B' Second connection configuration

[0587] 4A, 4A' Opening area of ​​the first connection configuration

[0588] 4B, 4B' Opening area of ​​the second connection configuration

[0589] 5A, 5A' Mouth-shaped portion of the first connection configuration

[0590] 5B, 5B' Mouth-shaped portion of the second connection configuration

[0591] 6 Cover device

[0592] 7 Splitting Elements

[0593] 8 Arrows indicating movement

[0594] 9 Central axis or axis of symmetry

[0595] 10A, 10B Fixing device

[0596] 11 Rotation Arrow

[0597] 12 Fault Line

[0598] 13 Container

[0599] 14 Closure

[0600] 15 Inner circumference edge

[0601] 16 Outer circumferential edge

[0602] 17 Gap

[0603] 18A Lead for first connection configuration

[0604] 18B Guide for the second connection configuration

[0605] 19 feet

[0606] 20 points

[0607] 21 Connection part

[0608] 22 Ring-shaped part

[0609] 23 Closure device (first connection configuration)

[0610] 24 Vulnerabilities (First Connection Configuration)

[0611] 25 Keep part

[0612] 26 Cover device

[0613] 27 Plane

[0614] 28 Frame

[0615] 29 Reinforcement

[0616] 30 Transformation Device

[0617] 31 wall

[0618] 32 Piercing and / or cutting edges

[0619] 33 Closure device (second connection configuration)

[0620] 34 Vulnerability (Second Connection Configuration)

[0621] 35A', 35B' wall (container / container blank)

[0622] 36A', 36B' edge (container / container blank)

[0623] 37A', 37B' Ring-shaped and / or tubular portion

[0624] Chambers 38A to 38C

[0625] 39 Seal Configuration

[0626] 40A to 40C Internal volume

[0627] 41A to 41C External volume

[0628] 42A to 42C Sealing part

[0629] 43A to 43C Sealing part

[0630] 44A, 44B Sealing surface

[0631] 45A, 45B Sealing surface

[0632] 46A, 46B Supporting part

[0633] 47 Notch

[0634] 48 Reinforcement elements

[0635] 49A, 49B strips

[0636] 50A, 50B side wall

[0637] 51A, 51B base

[0638] 52 Fixtures

[0639] 53 tank

[0640] 54 Blocking parts

[0641] 55 Edge

[0642] B Container System

[0643] B1 First container

[0644] B2 Second container

[0645] B3 Third container

[0646] B4 Fourth container

[0647] BR1 container blank

[0648] BR2 container blank

[0649] E1 Removal opening of first container

[0650] E2 Removal opening of the second container

[0651] F1 Bottle neck of the first container

[0652] F2 Bottle neck of the second container

[0653] FS Force

[0654] S1 Substance in first container

[0655] S2 Second container of material

[0656] S3 Third container substances

[0657] V1 Closure element of the first container

[0658] V2 Closure element of the second container

Claims

1. A connection arrangement for providing a fluid connection (2) between containers (B1, B2, B3), hereinafter referred to as a first connection arrangement, wherein the first connection arrangement comprises a rigid closure device (23) which, in an initial state, is sealingly held on a holding portion (25) of the first connection arrangement by means of a weak point / line (24), Features: The retaining portion (25) is deformable relative to the closure device (23) to thereby open the first connection configuration by tearing the weak point / line (24); tilting the area defined by the weak point / line (24) relative to the central axis (9) of the first connection configuration; and The retaining portion (25) is non-circular and perpendicular to the central axis (9) of the first connection configuration, so that the retaining portion (25) is deformed by inserting the retaining portion (25) into a deformation device (30) of at least substantially complementary shape and then rotating the retaining portion (25) around the central axis (9) relative to the deformation device (30).

2. The connection arrangement according to claim 1, characterized in that The closure device (23) is held by the weak point / line (24) in such a way that the closure device (23) is tilted during deformation of the holding portion (25).

3. The connection arrangement according to claim 1 or 2, characterized in that: The closure means (23) is configured in the shape of a slope starting from the weak point / line (24) provided at the edge.

4. The connection arrangement according to claim 3, characterized in that The closure device (23) is configured such that the closure device (23) is continuously tilted as the deformation progresses.

5. The connection arrangement according to claim 1 or 2, characterized in that: The retaining portion (25) is configured in the shape of a neck or a collar and / or in which the retaining portion (25) is or forms a portion of a mouth-shaped portion.

6. The connection arrangement according to claim 1 or 2, characterized in that: The retaining portion (25) is configured in the shape of a tube having a flexibly deformable wall.

7. The connection arrangement according to claim 1 or 2, characterized in that: The rigid closing device is a closing plate.

8. The connection arrangement according to claim 1 or 2, characterized in that: The weak point / line is a thin point / line, and / or the weak point / line forms an open area or a part thereof.

9. A connection configuration according to claim 1 or 2, characterized in that the connection configuration is configured to be connected to a container blank (BR1, BR2) to form a container (B1, B2), and the container blank (BR1, BR2) has an opening with a wall (35A', 35B'), and the connection configuration can be inserted into the opening and tightly connected to the container blank (BR1, BR2).

10. The connection arrangement according to claim 9, characterized in that The connection arrangement may be tightly connected to the container blank (BR1, BR2) by welding, adhesive bonding or by some other method.

11. A connection arrangement for providing a fluid connection (2) between containers (B1, B2, B3), hereinafter referred to as a first connection arrangement, wherein the first connection arrangement comprises a rigid closure device (23) which, in an initial state, is sealingly held on a holding portion (25) of the connection arrangement by means of a weak point / line (24), Features: The retaining portion (25) is deformable relative to the closure device (23) to thereby open the first connection configuration by tearing the weak point / line (24); The holding portion (25) comprises a frame (28) and in the initial state the closure device (23) is tilted relative to the frame (28) so that in the deflection area directly adjacent to the weak point / line (24), the frame (28) is gradually deflected relative to the closure device (23); as well as The retaining portion (25) is non-circular and perpendicular to the central axis (9) of the first connection configuration, so that the retaining portion (25) is deformed by inserting the retaining portion (25) into a deformation device (30) of at least substantially complementary shape and then rotating the retaining portion (25) around the central axis (9) relative to the deformation device (30).

12. The connection arrangement according to claim 11, characterized in that Due to the stepwise deflection, during deformation, the closing device (23) protrudes behind the frame (28) and / or a shearing movement of the closing device (23) relative to the frame (28) occurs.

13. The connection arrangement according to claim 11 or 12, characterized in that The closure means (23) is configured in the shape of a slope starting from the weak point / line (24) provided at the edge.

14. The connection arrangement according to claim 13, characterized in that The closure device (23) is configured such that the closure device (23) is continuously tilted as the deformation progresses.

15. The connection arrangement according to claim 11 or 12, characterized in that The retaining portion (25) is configured in the shape of a neck or a collar and / or in which the retaining portion (25) is or forms a portion of a mouth-shaped portion.

16. The connection arrangement according to claim 11 or 12, characterized in that The retaining portion (25) is configured in the shape of a tube having a flexibly deformable wall.

17. The connection arrangement according to claim 11 or 12, characterized in that: The connection configuration is configured to connect to a container blank (BR1, BR2) to form a container (B1, B2), while the container blank (BR1, BR2) has an opening of a wall (35A', 35B'), and the connection configuration is inserted into the opening and tightly connected to the container blank (BR1, BR2).

18. The connection arrangement according to claim 17, characterized in that: The connection arrangement is tightly connected to the container blank (BR1, BR2) by welding, adhesive bonding or by material engagement.

19. The connection arrangement according to claim 17, characterized in that The connection arrangement may be tightly connected to the container blank (BR1, BR2) by welding, adhesive bonding or by some other method.

20. The connection arrangement according to claim 11 or 12, characterized in that The rigid closing device is a closing plate.

21. The connection arrangement according to claim 11 or 12, characterized in that The weak point / line is a thin point / line, and / or the weak point / line forms an open area or a part thereof.

22. A connection arrangement for providing a fluid connection (2) between containers (B1, B2, B3), hereinafter referred to as a first connection arrangement, wherein the first connection arrangement comprises a rigid closure device (23) which, in an initial state, is sealingly held on a holding portion (25) of the connection arrangement by means of a weak point / line (24), Features: The retaining portion (25) is deformable relative to the closure device (23) to thereby open the first connection configuration by tearing the weak point / line (24); The closure device (23) includes a reinforcement member (29); and The retaining portion (25) is non-circular and perpendicular to the central axis (9) of the first connection configuration, so that the retaining portion (25) is deformed by inserting the retaining portion (25) into a deformation device (30) of at least substantially complementary shape and then rotating the retaining portion (25) around the central axis (9) relative to the deformation device (30).

23. The connection arrangement according to claim 22, characterized in that The retaining portion (25) is configured in the shape of a neck or a collar and / or in which the retaining portion (25) is or forms a portion of a mouth-shaped portion.

24. The connection arrangement according to claim 22, characterized in that The retaining portion (25) is configured in the shape of a tube having a flexibly deformable wall.

25. A connection arrangement according to claim 22 or 23, characterised in that: The connection configuration is configured to connect to a container blank (BR1, BR2) to form a container (B1, B2), and the container blank (BR1, BR2) has an opening of a wall (35A', 35B'), and the connection configuration can be inserted into the opening and tightly connected to the container blank (BR1, BR2).

26. The connection arrangement according to claim 25, characterized in that The connection arrangement may be tightly connected to the container blank (BR1, BR2) by welding, adhesive bonding or by some other method.

27. A connection arrangement according to claim 22 or 23, characterized in that The rigid closing device is a closing plate.

28. A connection arrangement according to claim 22 or 23, characterised in that The weak point / line is a thin point / line, and / or the weak point / line forms an open area or a part thereof.

29. A connection arrangement according to claim 22 or 23, characterised in that The reinforcement (29) is formed by one or more ribs and / or the reinforcement (29) is configured in a sloped shape starting from the weak point / line (24) provided at the edge.

30. A connection arrangement for providing a fluid connection (2) between containers (B1, B2, B3), hereinafter referred to as a first connection arrangement, wherein the first connection arrangement comprises a rigid closure device (23) which, in an initial state, is sealingly retained on a retaining portion (25) of the connection arrangement by means of a weak point / line (24), Features: The retaining portion (25) is deformable relative to the closure device (23) to thereby open the first connection configuration by tearing the weak point / line (24); as well as The retaining portion (25) is non-circular and perpendicular to the central axis (9) of the first connection configuration, so that the retaining portion (25) is deformed by inserting the retaining portion (25) into a deformation device (30) of at least substantially complementary shape and then rotating the retaining portion (25) around the central axis (9) relative to the deformation device (30).

31. A connection arrangement according to claim 30, wherein the retaining portion (25) is configured in the shape of a neck or a collar and / or wherein the retaining portion (25) is or forms part of a mouth-shaped portion.

32. The connection arrangement according to claim 30, characterized in that The retaining portion (25) is configured in the shape of a tube having a flexibly deformable wall.

33. A connection arrangement according to claim 30 or 31, characterised in that: The connection configuration is configured to connect to a container blank (BR1, BR2) to form a container (B1, B2), and the container blank (BR1, BR2) has an opening of a wall (35A', 35B'), and the connection configuration can be inserted into the opening and tightly connected to the container blank (BR1, BR2).

34. A connection arrangement according to claim 33, characterised in that The connection arrangement may be tightly connected to the container blank (BR1, BR2) by welding, adhesive bonding or by some other method.

35. The connection arrangement according to claim 33, characterized in that The rigid closing device is a closing plate.

36. The connection arrangement according to claim 33, characterized in that The weak point / line is a thin point / line, and / or the weak point / line forms an open area or a part thereof.

37. The connection arrangement according to claim 33, characterized in that The deformation of the retaining portion (25) occurs radially relative to the central axis (9) or in the direction of the central axis (9).

38. A connection arrangement for providing a fluid connection (2) between containers (B1, B2, B3), hereinafter referred to as a first connection arrangement, wherein the first connection arrangement comprises a rigid closure device (23) which, in an initial state, is sealingly held on a holding portion (25) of the connection arrangement by means of a weak point / line (24), Features: The retaining portion (25) is deformable relative to the closure device (23) to thereby open the first connection configuration by tearing the weak point / line (24); The retaining portion (25) has a piercing and / or cutting edge; and The retaining portion (25) is non-circular and perpendicular to the central axis (9) of the first connection configuration, so that the retaining portion (25) is deformed by inserting the retaining portion (25) into a deformation device (30) of at least substantially complementary shape and then rotating the retaining portion (25) around the central axis (9) relative to the deformation device (30).

39. A connection arrangement according to claim 38, characterised in that: The connection configuration is configured to connect to a container blank (BR1, BR2) to form a container (B1, B2), and the container blank (BR1, BR2) has an opening of a wall (35A', 35B'), and the connection configuration can be inserted into the opening and tightly connected to the container blank (BR1, BR2).

40. The connection arrangement according to claim 39, characterized in that The connection arrangement may be tightly connected to the container blank (BR1, BR2) by welding, adhesive bonding or by some other method.

41. A connection arrangement according to claim 38 or 39, characterised in that The closing device is a rigid and / or closed plate.

42. A connection arrangement according to claim 38 or 39, characterised in that The weak point / line is a thin point / line, and / or the weak point / line forms an open area or a part thereof.

43. A method for providing a fluid connection (2) between separation containers (B1, B2, B3), wherein a first container (B1, B1') comprises a first connection arrangement having a first opening area (4A, 4A') and a first mouth-shaped portion (5A, 5A') adjacent to or surrounding the first opening area (4A, 4A'), wherein the first mouth-shaped portion (5A, 5A') is deformable so that the deformation enables the first opening area (4A, 4A') to be opened, wherein the second container (B2, B3) comprises a second connection configuration, The method comprises, to provide the fluid connection (2): interconnecting the first connection configuration and the second connection configuration, The second connection configuration deforms the mouth-shaped portion (5A, 5A') of the first connection configuration outside the first opening area (4A, 4A') to open the first opening area (4A, 4A') of the first connection configuration, thereby generating mechanical tension in the first opening area (4A, 4A') to tear the first opening area (4A, 4A'), and the deformation causes the first opening area (4A, 4A') of the first connection configuration to open; and The first mouth-shaped part (5A, 5A') of the first connection configuration and the second mouth-shaped part (5B, 5B') of the second connection configuration are non-circular and perpendicular to the central axis (9) of the first connection configuration and the second connection configuration. The first connection configuration and the second connection configuration are arranged in a directional manner within each other or pushed into each other's mouth-shaped parts. At the same time, the first connection configuration and the second connection configuration or the first mouth-shaped part (5A, 5A') and the second mouth-shaped part (5B, 5B') rotate relative to each other, thereby causing the first mouth-shaped part (5A, 5A') of the first connection configuration to deform outside the first opening area (4A, 4A'), thereby making the first opening area (4A, 4A') open.

44. The method according to claim 43, characterized in that The containers (B1, B2, B3) are bottles.

45. A container system (B) comprising at least two containers (B1, B2, B3), and a connection system (1), wherein the containers (B1, B2, B3) respectively comprise at least one of a first connection configuration and a second connection configuration, and at least one of the containers (B1, B2) comprises a removal opening (E1, E2) and / or the containers (B1, B2, B3) are configured to provide a fluid connection (2) between the containers (B1, B2, B3) using the first connection configuration and the second connection configuration; The connection system (1) comprises at least two connection configurations configured for preparing the fluid connection (2), namely, a first connection configuration and a second connection configuration, wherein in an initial state, the first connection configuration and the second connection configuration are respectively fluid-tight, wherein the first connection configuration has a first opening area (4A, 4A'), and wherein the first connection configuration can be deformed outside the first opening area (4A, 4A') and is configured such that the deformation causes the first connection configuration to open in the first opening area (4A, 4A'); wherein the first connection configuration comprises a first mouth-shaped portion (5A, 5A') adjacent to or surrounding the first opening area (4A, 4A'), wherein the first mouth-shaped portion (5A, 5A') is deformable such that the deformation enables the first opening area (4A, 4A') to be opened; wherein the mouth-shaped portion (5A, 5A') is mesh-shaped, neck-shaped, wall-shaped, and / or flexible; and / or the first mouth-shaped portion (5A, 5A') is more flexible and / or stable than the first opening area (4A, 4A'), so that when the first mouth-shaped portion (5A, 5A') is deformed, the first opening area (4A, 4A') opens; and The first mouth-shaped part (5A, 5A') of the first connection configuration and the second mouth-shaped part (5B, 5B') of the second connection configuration are non-circular and perpendicular to the central axis (9) of the first connection configuration and the second connection configuration. The first connection configuration and the second connection configuration are arranged in a directional manner within each other or pushed into each other's mouth-shaped parts. At the same time, the first connection configuration and the second connection configuration or the first mouth-shaped part (5A, 5A') and the second mouth-shaped part (5B, 5B') rotate relative to each other, thereby causing the first mouth-shaped part (5A, 5A') of the first connection configuration to deform outside the first opening area (4A, 4A'), thereby making the first opening area (4A, 4A') open.

46. ​​The container system according to claim 45, characterized in that The containers (B1, B2, B3) are bottles.

47. The container system according to claim 45, characterized in that The first opening area (4A, 4A') is opened by tearing.

48. The container system (B) according to claim 45, characterized in that The opening is caused by at least substantially radially tensioning and / or stretching the first opening region (4A, 4A') to fracture; and / or The second connection configuration is configured to open the first connection configuration, wherein the second connection configuration is configured to open the first opening area (4A, 4A') of the first connection configuration by deforming the first connection configuration.

49. The container system (B) according to claim 45, characterized in that By rotating the first connection arrangement and the second connection arrangement relative to each other around a central axis (9), the deformation is produced by the rotation and / or the first opening area (4A, 4A') of the first connection arrangement is opened.

50. A use of a container system (B) according to claim 45, wherein the first container (B1) comprises a first substance (S1), wherein the second container (B2) comprises a second substance (S2), wherein at least one of these containers (B1, B2) comprises a removal opening (E1, E2) and these containers (B1, B2) respectively comprise a first connection configuration and a second connection configuration for providing a fluid connection between these containers (B1, B2), and the container system (B) is used to prepare a mixture of substances, wherein these containers are fluidically connected to each other via the first connection configuration and the second connection configuration so that these substances (S1, S2) are mixed.

51. The use according to claim 50, wherein the first substance (S1) is a first vaccine for preventing a first disease, wherein the second substance (S2) is a second vaccine for preventing a second disease different from the first disease, wherein the mixture of these substances (S1, S2) is a combination vaccine for simultaneous immunization against different diseases, and wherein these substances (S1, S2) are mixed to form the combination vaccine.

52. The use according to claim 50 or 51, wherein the first connection configuration and the second connection configuration are respectively fluid-tight in an initial state, and The first connection configuration has a first opening area (4A, 4A'), and the first connection configuration can be deformed outside the first opening area (4A, 4A'), and is configured so that the deformation causes the first connection configuration to open in the first opening area (4A, 4A').

53. Use according to claim 52, wherein the first opening area (4A, 4A') is unstable.

54. Use according to claim 52, wherein the first opening area (4A, 4A') is film-like and / or brittle.

55. The use according to claim 50 or 51, characterized in that The opening is caused by at least substantially radially tensioning and / or stretching the first opening region (4A, 4A') to fracture; and / or The second connection configuration is configured to open the first connection configuration, wherein the second connection configuration is configured to open the first opening area (4A, 4A') of the first connection configuration by deforming the first connection configuration.

56. The use according to claim 50 or 51, characterized in that By rotating the first connection arrangement and the second connection arrangement relative to each other around a central axis (9), the deformation is produced by the rotation and / or the first opening area (4A, 4A') of the first connection arrangement is opened.

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