Liquid transfer module and liquid transfer workstation having the same

Abstract

The present invention discloses a pipetting module and a pipetting workstation having the pipetting module. The pipetting module comprises: a liquid suction cavity, a plurality of plungers slidably arranged in the liquid suction cavity, and a plurality of pipette assemblies which can be selectively installed in the liquid suction cavity and are provided with pipelines; a plurality of air guide channels for different plungers to move are provided inside the liquid suction cavity, and the gas in the air guide channels is squeezed out under the movement of the plungers, at least one air guide channel is connected to the pipeline, and different pipelines can be connected to different numbers of air guide channels, so that the medium flow rate discharged from the pipelines in different pipette assemblies is different. The above-mentioned pipetting module can quickly realize the installation and replacement of pipette assemblies of different ranges.

Description

Technical Field

[0001] The present invention relates to the technical field of liquid transfer equipment, and in particular to a liquid transfer module and a liquid transfer workstation having the liquid transfer module. Background Art

[0002] As we all know, the pipetting workstation can be used in biological, medical and scientific research experiments. It is suitable for standard workbenches and biological safety cabinets, and is suitable for universal tips of conventional handheld pipettes. It can automatically complete functions such as automatic installation and unloading of tips, pipetting, mixing, sample blowing, reverse aspiration, etc.

[0003] Generally speaking, pipetting modules and pipetting workstations often adopt a single-channel single-range setting. The pipetting modules for different ranges are set independently of each other, which makes the cost high. In addition, each range of the pipetting module needs to be debugged separately, the maintenance and calibration time is long, and the utilization efficiency is low.

[0004] In view of this, how to conveniently replace pipetting modules with different ranges is a technical issue that technicians in this field need to consider. Summary of the invention

[0005] The object of the present invention is to provide a pipetting module and a pipetting workstation having the pipetting module, which can quickly realize the installation and replacement of pipette assemblies with different ranges.

[0006] To achieve the above-mentioned object, the present invention provides a liquid transfer module, comprising: a liquid aspiration cavity, a plurality of plungers slidably arranged in the liquid aspiration cavity, and a plurality of liquid transfer tube assemblies which can be selectively installed in the liquid aspiration cavity and are provided with pipelines;

[0007] A plurality of air-guiding channels are provided inside the liquid-imbibing cavity for respectively moving different plungers. The gas in the air-guiding channels is squeezed out under the movement of the plungers. At least one air-guiding channel is connected to the pipeline, and different pipelines can be connected to different numbers of air-guiding channels, so that the medium flow rate discharged from the pipelines in different pipette assemblies is different.

[0008] Optionally, a passage is provided at the top of the pipette assembly, and both ends of the passage are respectively connected to a pipeline and an air guide channel, and the multiple plungers specifically include: a middle plunger that can extend into the passage from top to bottom and a side plunger arranged adjacent to the middle plunger.

[0009] Optionally, the plurality of pipette assemblies specifically include: a first range pipette assembly and a second range pipette assembly;

[0010] The top side wall of the first range pipette assembly is provided with an air release groove, and the gas squeezed out by the side plunger can be discharged through the air release groove;

[0011] A radial guide groove communicated with the pipeline is disposed on the top side wall of the second range pipette assembly, and the gas squeezed out by the side plunger can enter the pipeline through the radial guide groove.

[0012] Optionally, there are two side plungers, and the multiple pipette assemblies are specifically third-range pipette assemblies. The top side wall of the third-range pipette assembly is provided with an air relief groove and a radial guide groove. The gas squeezed out by one of the side plungers can be discharged through the air relief groove, and the gas squeezed out by the other side plunger can enter the pipeline through the radial guide groove.

[0013] Optionally, the pipette assembly includes a body, a pipette passing through the body, and a flange connecting the body and the pipette, the pipette is provided with pipelines and passages, the top of the pipette is located above the flange and is arranged in the liquid aspiration cavity.

[0014] Optionally, the pipette is provided with a limiting ring groove, the side wall of the liquid aspiration cavity is provided with a mounting groove located at one side of the limiting ring groove and connected to the limiting ring groove, and a limiting column rod is slidably provided in the mounting groove;

[0015] When the limiting column is fixed in the installation groove under the action of the pre-tightening force, the limiting column and the limiting ring groove are engaged and matched, so that the pipette assembly is fixed in the liquid aspiration cavity;

[0016] When the limiting column rod slides in the installation groove by overcoming the pre-tightening force, the limiting column rod and the limiting ring groove are separated from each other, so that the pipette assembly and the liquid aspiration cavity are disconnected.

[0017] Optionally, all plunger sleeves are provided with a sealing ring located in the liquid absorption cavity, and the liquid absorption cavity is provided with a groove located above the sealing ring and below the top of the plunger, and the groove is filled with a sealing locking plate for spacing any two adjacent plungers, and the sealing locking plate can prevent the sealing ring from moving with the plunger.

[0018] Optionally, the top of the plunger is provided with an annular convex head located above the liquid absorption cavity, a driving block is provided above the liquid absorption cavity, the driving block is provided with an accommodating cavity for accommodating the annular convex head, and a mounting through groove is provided on the bottom end surface of the accommodating cavity to connect the plunger and the driving block;

[0019] A quick lock block is slidably arranged in the accommodating cavity, and the upper and lower end surfaces of the quick lock block respectively abut against the upper and lower inner walls of the accommodating cavity. A positioning groove is arranged on the bottom end surface of the quick lock block, and the positioning groove fits the annular protrusion.

[0020] Optionally, it also includes a liquid suction drive and a liquid transfer drive that can be independently operated and arranged side by side, the output end of the liquid suction drive is connected to the plunger, the output end of the liquid transfer drive is connected to a sliding block, the liquid suction cavity is fixedly connected to a guide rail, the sliding block and the guide rail are slidably connected, and the output end of the liquid suction drive and the output end of the liquid transfer drive are arranged side by side;

[0021] When the aspiration drive is running, the plunger moves relative to the aspiration cavity. When the transfer drive is running and the position of the sliding block is fixed, the transfer cavity, the plunger, the aspiration drive, the transfer drive and the guide rail move synchronously.

[0022] The present invention also provides a liquid transfer workstation, comprising the liquid transfer module mentioned above.

[0023] Compared with the above-mentioned background technology, in the pipette module provided by the embodiment of the present invention, one of multiple pipette assemblies of different ranges can be selectively installed in the pipette cavity, and at least one air guide channel inside the pipette cavity can be connected to the pipeline of the pipette assembly, and the gas in the air guide channel is discharged into the pipeline under the movement of the plunger; that is, pipette assemblies of different ranges can be used in conjunction with the pipette cavity, and different pipelines can be connected to different numbers of air guide channels, so that the medium flow rate discharged from the pipelines in the pipette assemblies of different ranges is different; it can be seen that in the pipette module configured in this way, the pipette cavity can be adapted to pipette assemblies of different ranges, which can save production costs while reducing debugging time and improving replacement efficiency.

[0024] The embodiment of the present invention further provides a pipetting workstation having a pipetting module, which has the above-mentioned beneficial effects and will not be described in detail here. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0026] Figure 1 A schematic diagram of a first liquid transfer module provided by an embodiment of the present invention;

[0027] Figure 2-Figure 3 Schematic diagrams of different angles of the first liquid transfer module provided by an embodiment of the present invention;

[0028] Figure 4 for Figure 3 Sectional view along AA direction;

[0029] Figure 5 A side view of a first liquid transfer module provided by an embodiment of the present invention;

[0030] Figure 6 for Figure 5 Sectional view along CC direction;

[0031] Figure 7A side view of a second liquid transfer module provided by an embodiment of the present invention;

[0032] Figure 8 for Figure 7 Sectional view along EE direction;

[0033] Fig. 9 An exploded view of a third liquid transfer module provided by an embodiment of the present invention;

[0034] Fig.10 A side view of a third liquid transfer module provided by an embodiment of the present invention;

[0035] Fig.11 for Fig.10 The cross-sectional view along the GG direction;

[0036] Fig.12 A front view of a third liquid transfer module provided by an embodiment of the present invention;

[0037] Fig.13 for Fig.12 The cross-sectional view along the II direction;

[0038] Fig.14 for Fig.12 The cross-sectional view along the JJ direction;

[0039] Fig.15 Schematic diagrams of three pipette assemblies provided by embodiments of the present invention;

[0040] Fig.16 Side views of three pipette assemblies provided by embodiments of the present invention;

[0041] Fig.17 A top view of three pipette assemblies provided by embodiments of the present invention;

[0042] Fig.18 for Fig.17 The cross-sectional view along the KK axis;

[0043] Fig.19 A schematic diagram of a driving block of a liquid transfer module provided in an embodiment of the present invention;

[0044] Fig. 20 A schematic diagram of a sealing and locking piece of a liquid transfer module provided in an embodiment of the present invention;

[0045] Fig.21 A schematic diagram of a quick-lock block of a liquid transfer module provided in an embodiment of the present invention;

[0046] in:

[0047] 1-liquid suction cavity, 11-air guide channel, 12-installation slot, 13-limiting column, 14-slot, 15-pressing rod, 16-plug, 17-elastic part, 18-nut,

[0048] 2- plunger, 21- middle plunger, 22- side plunger,

[0049] 201-Ring convex head,

[0050] 3-pipette assembly, 31-first range pipette assembly, 32-second range pipette assembly, 33-third range pipette assembly,

[0051] 301- pipeline, 302- passage, 303- air release groove, 304- radial guide groove, 305- body, 306- pipette, 307- flange, 308- limit ring groove, 309- sealing ring, 310- screw, 311- exhaust hole,

[0052] 4- Sealing ring,

[0053] 5-sealing locking piece, 51-embedded groove, 52-positioning hole, 53-positioning rod,

[0054] 6-driving block, 61-accommodating cavity, 62-mounting slot, 63-positioning rod hole,

[0055] 7-quick lock block, 71-positioning slot, 72-mounting hole,

[0056] 8-liquid suction drive, 81-mounting plate, 82-liquid suction limit block, 83-liquid suction screw, 84-liquid suction in place sensor, 85-liquid suction moving rod,

[0057] 9-pipette drive, 91-slide block, 92-guide rail, 93-pipette screw, 94-pipette in-place sensor, 95-base plate. DETAILED DESCRIPTION

[0058] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0059] In order to enable those skilled in the art to better understand the scheme of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0060] The pipetting module provided in the embodiment of the present invention is described in the attached manual. Figure 1 To Attachment Fig.21As shown, it includes: a liquid suction chamber 1, a plurality of plungers 2 and a plurality of pipette assemblies 3.

[0061] The liquid-absorbing cavity 1 can be arranged in a vertical shape, and a plurality of air-guiding channels 11 are arranged inside the cavity. Each air-guiding channel 11 can allow a plunger 2 to move, and the size of the air-guiding channel 11 matches the size of the plunger 2 so that the gas in the air-guiding channel 11 can be squeezed out under the movement of the plunger 2.

[0062] The pipetting module involved in this article includes three vertically arranged air-conducting channels 11, and three plungers 2 are arranged, and the bottom of the plunger 2 extends into the air-conducting channel 11. When the plunger 2 moves downward, the gas in the air-conducting channel 11 flows downward.

[0063] The pipette assembly 3 in this article can be specifically set as three pipette assemblies with different ranges, namely a first-range pipette assembly 31, a second-range pipette assembly 32 and a third-range pipette assembly 33. The range of the first-range pipette assembly 31 can be specifically 20 microliters, the range of the second-range pipette assembly 32 can be specifically 1250 microliters, and the range of the third-range pipette assembly 33 can be specifically 200 microliters.

[0064] The pipette assembly 3 is provided with a pipeline 301, that is, the first range pipette assembly 31, the second range pipette assembly 32 and the third range pipette assembly 33 are all provided with a pipeline 301.

[0065] At least one gas guide channel 11 is connected to the pipeline 301, and different pipelines 301 can be connected to different numbers of gas guide channels 11, so that the gas flow rates discharged from the pipelines 301 in different pipette assemblies 3 are different; it can be seen that the medium discharged from the pipeline 301 is usually gas. Of course, according to actual needs, the medium discharged from the pipeline 301 can also be liquid, etc.

[0066] As the instruction manual Figure 4 , for the case where the third range pipette assembly 33 is installed in the aspiration cavity 1, the two gas guide channels 11 are connected to the pipeline 301, that is, the gas discharged by the two plungers 2 enters the pipeline 301 of the third range pipette assembly 33; similarly, refer to the appendix of the specification Figure 8 When the second range pipette assembly 32 is installed in the aspiration cavity 1, the three gas guide channels 11 are connected to the pipeline 301, that is, the gas discharged by the three plungers 2 enters the pipeline 301 of the second range pipette assembly 32; Fig.14 , only one air guide channel 11 (attached Fig.14 The pipe 301 (not shown) is connected to the first range pipette assembly 31.

[0067] It can be seen that, for pipette assemblies 3 of different measuring ranges, the pipeline 301 thereof can be connected to different numbers of gas guide channels 11 , thereby achieving different operations.

[0068] A passage 302 is provided at the top of the pipette assembly 3. The passage 302 can be arranged vertically. The two ends of the passage 302 are respectively connected to the pipeline 301 and an air guide channel 11. The air guide channel 11 connected to the passage 302 can be regarded as an intermediate channel. The intermediate channel, the passage 302 and the pipeline 301 can be vertically arranged from top to bottom to facilitate the circulation of airflow.

[0069] The plurality of plungers 2 are specifically a middle plunger 21 and side plungers 22 . The number of the side plungers 22 may specifically be two. The bottom of the middle plunger 21 may extend into the passage 302 from top to bottom.

[0070] During operation, the bottom of the middle plunger 21 passes through the air guide channel 11 (middle channel) and then extends into the passage 302, so that the airflow in the air guide channel 11 (middle channel) and the passage 302 can flow into the pipeline 301. Of course, since there may be a certain gap between the air guide channel 11 (middle channel) and the passage 302, most of the airflow is generated by the middle plunger 21 extending into the passage 302, but it does not affect the part of the airflow in the air guide channel 11 (middle channel) being squeezed into the pipeline 301.

[0071] The cross-sectional dimensions of the three plungers 2 can be set to be different. In this article, the cross-sectional dimension of the middle plunger 21 can be set to the smallest, and the cross-sectional dimensions of the two side plungers 22 are larger than the cross-sectional dimension of the middle plunger 21, and the cross-sectional dimensions of the two side plungers 22 are different; in this way, the requirements for different measuring ranges can be met.

[0072] The three plungers 2 can move synchronously, and the top side wall of the first range pipette assembly 31 is provided with two air release grooves 303; Fig.14 The middle plunger 21 extends into the passage 302, and the two side plungers 22 are located on the outside of the pipette assembly 3. The three plungers 2 move downward synchronously, and the airflow squeezed by the two side plungers 22 is discharged through the two air release grooves 303 respectively, and does not enter the pipeline 301.

[0073] The top side wall of the second range pipette assembly 32 is provided with two radial guide grooves 304 connected to the pipeline 301, and the two radial guide grooves 304 are respectively located on both sides. Figure 8 The middle plunger 21 extends into the passage 302, the two side plungers 22 are located outside the pipette assembly 3, and the three plungers 2 move downward synchronously. The airflow squeezed by the two side plungers 22 enters different radial guide grooves 304 and enters the pipeline 301 respectively.

[0074] Since the three air guide channels 11 can be arranged vertically, in order to guide the air guide channels 11 on both sides toward the direction of the pipette assembly 3, the air guide channels 11 on both sides should be provided with transverse guide channels so as to guide the gas into the gas relief groove 303 and the radial guide groove 304. The two radial guide grooves 304 are located at different positions in the axial direction, and correspondingly, the transverse guide channel should also have a certain drop in the height direction so that the radial guide groove 304 and the transverse guide channel correspond one to one; plugs 16 can also be provided at the bottom of the air guide channels 11 on both sides to block the air guide channels 11. When the side plunger 22 moves downward, the gas will enter the transverse guide channel from the air guide channel 11, and finally flow into the gas relief groove 303 and the radial guide groove 304.

[0075] For the third range pipette assembly 33, the top side wall thereof is provided with an air release groove 303 and a radial guide groove 304. Figure 4 Taking the orientation shown as an example, the gas squeezed out by the side plunger 22 on the left side passes through the air guide channel 11 and enters the air discharge groove 303, and is finally discharged out of the pipette assembly 3; the gas squeezed out by the side plunger 22 on the right side passes through the air guide channel 11 and enters the radial guide groove 304, and finally enters the pipeline 301.

[0076] In summary, it can be seen that the internal structure of the pipette cavity 1 in this article can adapt to the use of three pipette assemblies 3 of different ranges, and the top structure of each pipette assembly 3 of different ranges is different; when four or even five plungers 2 are set in the pipette cavity 1, the pipette cavity 1 can inevitably adapt to more pipette assemblies 3 of different ranges, and the structures of pipette assemblies 3 of different ranges should also be improved accordingly, which will not be elaborated in this article.

[0077] For the structure of the pipette assembly 3, refer to the attached manual. Fig.15 To Attachment Fig.18 Whether it is the first range pipette assembly 31, the second range pipette assembly 32 or the third range pipette assembly 33, they all include a body 305, a pipette 306 and a flange 307. The pipette 306 passes through the body 305. The pipette 306 is provided with a pipeline 301 and a passage 302. The top of the pipette 306 is located outside the body 305. The flange 307 is sleeved on the body 305. The flange 307 has a threaded hole. After the screw 310 is inserted into the threaded hole, the pipette 306 can be fixed to the body 305.

[0078] When the pipette assembly 3 needs to be installed in the liquid pipetting cavity 1, the portion above the flange 307 should extend into the liquid pipetting cavity 1. The liquid pipetting cavity 1 may be provided with a socket groove for the pipette 306 to extend into. The pipette 306 may also be provided with a sealing ring 309. The sealing ring 309 and the liquid pipetting cavity 1 are fitted together to maintain an airtight seal.

[0079] For pipette assemblies 3 of different measuring ranges, the position of the sealing ring 309 can be set to be different. Fig.18 The two sealing rings 309 of the first range pipette assembly 31 can be arranged on the outer periphery of the passage 302. In view of the fact that the first range pipette assembly 31 is not provided with a radial guide groove 304 and the gas needs to be discharged by using the air discharge groove 303, the two sealing rings 309 are arranged in an upper position to maintain the sealing of the intermediate plunger 21 and the passage 302.

[0080] The two sealing rings 309 of the second range pipette assembly 32 can be arranged on the lower side of the radial guide groove 304. Since the two radial guide grooves 304 are connected to the pipeline 301, in order to achieve reliable sealing between the pipette 306 and the sleeve groove, the two sealing rings 309 are arranged on the lower side of the radial guide groove 304.

[0081] The two sealing rings 309 of the third range pipette assembly 33 can be respectively arranged on the upper and lower sides of the radial guide groove 304. Since the third range pipette assembly 33 is provided with an air relief groove 303 and a radial guide groove 304, the two sealing rings 309 respectively located on the upper and lower sides of the radial guide groove 304 can seal different axial positions to improve sealing reliability.

[0082] Reference Manual Attached Fig.18 For the first-range pipette assembly 31 and the third-range pipette assembly 33, both are provided with an air relief groove 303. In order to discharge the gas in the air relief groove 303, the main body 305 is provided with an exhaust hole 311. The air relief groove 303 is connected with the exhaust hole 311 after passing through the flange 307, that is, the gas squeezed out by the side plunger 22 passes through the air relief groove 303 and is discharged from the exhaust hole 311. It can be considered that the gas in the air guide channel 11 is discharged to the outside of the liquid aspiration cavity 1 through the exhaust hole 311.

[0083] Regarding the fixing method of the pipette assembly 3 and the liquid aspiration chamber 1, the pipette 306 can be provided with a limiting ring groove 308, and the side wall of the liquid aspiration chamber 1 is provided with a mounting groove 12, which is located on one side of the limiting ring groove 308, and the mounting groove 12 and the limiting ring groove 308 are connected.

[0084] A limiting column 13 is slidably provided in the mounting groove 12, and an elastic member 17 such as a spring may also be provided in the mounting groove 12, one end of the elastic member 17 abuts against the inner wall of the mounting groove 12, and the other end of the elastic member 17 abuts against the limiting column 13, so as to provide a certain pre-tightening force to the limiting column 13; of course, the limiting column 13 can also be set as an elastic rod, which can maintain a certain pre-tightening force itself.

[0085] Under the action of the preload force, when the limiting column 13 is fixed to the mounting groove 12, the limiting column 13 and the limiting ring groove 308 are engaged with each other, so that the position of the limiting ring groove 308 is fixed by the limiting column 13, that is, the pipette assembly 3 and the liquid aspiration cavity 1 are fixed.

[0086] When the limiting column 13 overcomes the pre-tightening force and slides in the installation groove 12, the limiting column 13 and the limiting ring groove 308 are disengaged, and the pipette assembly 3 and the liquid aspiration cavity 1 are disconnected.

[0087] In order to facilitate the touch control of the limiting column rod 13, the installation groove 12 can be set as a stepped groove, the groove body with a smaller step groove is close to the outside, that is, the outer groove, and the groove body with a larger step groove is close to the inside, that is, the inner groove; the limiting column rod 13 can be specifically a stepped rod, the rod body with a larger step rod size is located in the inner groove, and the rod body with a smaller step rod size passes through the inner groove and extends out of the liquid suction cavity 1.

[0088] Instructions attached Figure 6 A schematic diagram of the limiting column 13 under the action of preload is shown, wherein the rod body of the limiting column 13 located outside the liquid aspiration chamber 1 can be sleeved with a nut 18, and the limiting column 13 and the nut 18 form a pressing rod 15; when the nut 18 is pressed, the elastic member 17 is compressed, and the limiting column 13 moves inward along the mounting groove 12, the limiting column 13 and the limiting ring groove 308 are out of contact, and the pipette assembly 3 and the liquid aspiration chamber 1 are disconnected.

[0089] For pipette assemblies 3 of different measuring ranges, the length of the pipette 306 above the flange 307 is set to be the same, and the limiting ring groove 308 is at the same position compared to the pipette 306. In addition, the length of the passage 302 can also be set to be the same. In this way, no matter what range the pipette assembly 3 is, it can be quickly installed in the liquid aspiration cavity 1 and is easy to disassemble, thereby improving operating efficiency.

[0090] All plungers 2 are sleeved with sealing rings 4 , which are located in the liquid aspiration cavity 1 . When the plunger 2 slides relative to the liquid aspiration cavity 1 , the sealing rings 4 can always keep the plunger 2 and the liquid aspiration cavity 1 sealed.

[0091] The liquid suction cavity 1 is provided with a groove 14, which is located above the sealing ring 4 and below the top of the plunger 2. In order to prevent the sealing ring 4 from moving synchronously with the plunger 2, a sealing locking piece 5 is filled in the groove 14. The sealing locking piece 5 can not only limit the upward movement of the sealing ring 4, but also serve as a spacing for any two adjacent plungers 2.

[0092] The thickness of the sealing locking piece 5 and the height of the groove 14 can be set to be the same, the sealing locking piece 5 and the liquid suction chamber 1 remain in a fixed position, the sealing ring 4 is sleeved on the plunger 2, and when the plunger 2 moves relative to the liquid suction chamber 1, the plunger 2 and the sealing locking piece 5 move relative to each other, and the sealing ring 4 moves synchronously with the plunger 2 within a certain range. When the sealing ring 4 moves upward and abuts against the sealing locking piece 5, since the sealing locking piece 5 is in a fixed position, the sealing locking piece 5 will prevent the sealing ring 4 from continuing to move upward, thereby ensuring the sealing reliability between the plunger 2 and the liquid suction chamber 1.

[0093] Reference Manual Attached Fig.21 The sealing locking sheet 5 is in sheet shape and is provided with a snap-fitting groove 51. The snap-fitting groove 51 is semicircular and its size matches the plunger 2 so as to space any two adjacent plungers 2. The sealing locking sheet 5 can also be provided with a positioning hole 52 in the thickness direction. A positioning rod 53 vertically penetrates the positioning hole 52. The bottom end of the positioning rod 53 abuts against the upper end surface of the flange 307. The top end of the positioning rod 53 can abut against a fixed position. In this way, the sealing locking sheet 5 can be fixed in the horizontal direction by the positioning rod 53, thereby improving the sealing effect of the plunger 2 and the liquid suction cavity 1.

[0094] An annular boss 201 is provided on the top of all plungers 2. The plunger 2 can be integrally formed. The annular boss 201 is located above the liquid absorption cavity 1. A driving block 6 can also be provided above the liquid absorption cavity 1. The driving block 6 has a receiving cavity 61, and the annular boss 201 is located in the receiving cavity 61.

[0095] The bottom end surface of the accommodating cavity 61 is provided with a mounting groove 62 to connect the plunger 2 and the driving block 6; obviously, the size of the mounting groove 62 should match the size of the plunger 2 so that each plunger 2 can enter a different mounting groove 62.

[0096] A quick lock block 7 is slidably disposed in the accommodating cavity 61 , and the upper and lower end surfaces of the quick lock block 7 respectively abut against the upper and lower inner walls of the accommodating cavity 61 . A positioning groove 71 is disposed on the bottom end surface of the quick lock block 7 , and the positioning groove 71 fits the annular protrusion 201 .

[0097] Reference Manual Attached Fig.19 and attached Fig. 20 When the plunger 2 and the driving block 6 are installed, the annular protrusion 201 of the plunger 2 is located in the accommodating cavity 61, and then the quick lock block 7 is installed in the accommodating cavity 61, and the positioning groove 71 can fit with the annular protrusion 201.

[0098] The quick lock block 7 may also be provided with a mounting hole 72, and the accommodating chamber 61 may also be provided with a fastening hole coaxial with the mounting hole 72. When the quick lock block 7 is installed in the accommodating chamber 61, the mounting hole 72 and the fastening hole are coaxial, and the quick lock block 7 and the driving block 6 can be fixed by bolts, etc., that is, the connection between the plunger 2 and the driving block 6 is completed. The bottom end surface of the accommodating chamber 61 may also be provided with a positioning rod through hole 63 for the top of the positioning rod 53 to pass through and then be fixed.

[0099] The pipetting module of this article also includes independently operable liquid suction driving component 8 and liquid transfer driving component 9, which can be installed on the mounting plate 81, and the output end of the liquid suction driving component 8 is connected to the plunger 2. When the liquid suction driving component 8 is running, the plunger 2 moves relative to the liquid suction chamber 1.

[0100] The output end of the liquid transfer drive 9 is connected to a sliding block 91, the sliding block 91 is slidably connected to the guide rail 92, and the output end of the liquid suction drive 8 and the output end of the liquid transfer drive 9 are arranged side by side. When the liquid transfer drive 9 is running and the position of the sliding block 91 is fixed, the liquid transfer cavity 1, the plunger 2, the liquid suction drive 8, the liquid transfer drive 9 and the guide rail 92 move synchronously.

[0101] The liquid suction drive component 8 can be specifically a motor or other components, which can be connected to a vertically arranged liquid suction screw 83. The end of the liquid suction screw 83 is connected to the drive block 6 through a screw nut. When the liquid suction drive component 8 is running, the liquid suction screw 83 rotates, and the drive block 6 can be driven to move through the screw nut, that is, the drive block 6 and the plunger 2 move synchronously to realize the liquid suction and discharge operation.

[0102] A liquid suction limit block 82 may also be provided below the mounting plate 81 to limit the movement of the driving block 6. When the driving block 6 moves upward to the limit position, the driving block 6 and the liquid suction limit block 82 abut against each other, and the driving block 6 cannot continue to drive the plunger 2 to move upward.

[0103] A liquid suction moving rod 85 can also be installed under the driving block 6. The liquid suction moving rod 85 is vertically arranged. The liquid suction moving rod 85 can move synchronously with the driving block 6. The relative position of the liquid suction in place sensor 84 is fixed and is used in conjunction with the liquid suction moving rod 85. The moving position of the driving block 6 is judged by the position change of the liquid suction moving rod 85 compared to the liquid suction in place sensor 84.

[0104] A guide rail 92 may be provided below the mounting plate 81 , the driving block 6 and the guide rail 92 are slidably connected, the guide rail 92 and the liquid suction chamber 1 are fixed, the liquid suction limit block 82 may be fixed to the guide rail 92 , and the liquid suction in place sensor 84 may also be fixed to the guide rail 92 .

[0105] A substrate 95 can be set at the bottom end of the guide rail 92, and the substrate 95 and the pipetting cavity 1 can be set as an integral whole. The pipetting drive 9 can be specifically a motor and other components. The pipetting drive 8 and the pipetting drive 9 are preferably arranged side by side. The pipetting drive 9 can be connected to a vertically arranged pipetting screw 93, and the end of the pipetting screw 93 can be connected to the sliding block 91 through a screw nut. When the pipetting drive 9 is running, the pipetting screw 93 rotates, and the sliding block 91 can be fixedly connected to other components. When the sliding block 91 is controlled to be stationary, the pipetting screw 93 moves along the sliding block 91, that is, the pipetting cavity 1, the plunger 2, the pipetting drive 8, the pipetting drive 9 and the guide rail 92 move synchronously, thereby realizing the up and down movement of the entire pipetting module; a pipetting in-place sensor 94 can also be set at the bottom of the substrate 95 to detect the position of the entire pipetting module.

[0106] It can be seen that in this article, the aspiration screw 83 and the pipetting screw 93 are respectively arranged on both sides of the guide rail 92, and the guide rail 92 can be embedded in the front and rear ends of the vertical body, which greatly saves assembly and use space, makes the structure of the pipetting module compact, improves space utilization, and facilitates subsequent use and maintenance.

[0107] The present invention provides a pipetting workstation with a pipetting module, which includes the pipetting module described in the above specific embodiment; other parts of the pipetting workstation can refer to the prior art and will not be elaborated in this article.

[0108] The above is a detailed introduction to the pipetting module and the pipetting workstation having the pipetting module provided by the present invention. Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. It should be pointed out that for ordinary technicians in this technical field, without departing from the principles of the present invention, the present invention can also be improved and modified in a number of ways, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.

Claims

1. A pipetting module, characterized in that: include: A liquid aspiration cavity (1), a plurality of plungers (2) slidably inserted into the liquid aspiration cavity (1), and a plurality of pipette assemblies (3) which can be selectively installed in the liquid aspiration cavity (1) and are provided with pipelines (301); The liquid-absorbing cavity (1) is provided with a plurality of air-guiding channels (11) for respectively facilitating the movement of different plungers (2), and the gas in the air-guiding channels (11) is squeezed out under the action of the movement of the plungers (2); A passage (302) is provided at the top of the pipette assembly (3), and the two ends of the passage (302) are respectively connected to the pipeline (301) and one of the air guide channels (11), and the plurality of plungers (2) specifically include: an intermediate plunger (21) that can extend from top to bottom into the passage (302) and a side plunger (22) disposed adjacent to the intermediate plunger (21); A top side wall of at least one of the pipette assemblies (3) is provided with an air release groove (303), through which the gas squeezed out by the side plunger (22) can be discharged; A radial guide groove (304) communicating with the pipeline (301) is provided on the top side wall of at least one of the pipette assemblies (3), and the gas squeezed out by the side plunger (22) can enter the pipeline (301) through the radial guide groove (304); A transverse guide channel is provided in the gas guide channel (11) so as to allow gas to be introduced into the gas relief groove (303) and the radial guide groove (304); At least one of the air guide channels (11) is in communication with the pipeline (301), and different pipelines (301) can be connected to different numbers of air guide channels (11), so that the medium flow rates discharged by the pipelines (301) in different pipette assemblies (3) are different.

2. The liquid transfer module according to claim 1, characterized in that: The plurality of pipette assemblies (3) specifically include: a first range pipette assembly (31) and a second range pipette assembly (32); The top side wall of the first range pipette assembly (31) is provided with an air release groove (303), and the gas squeezed out by the side plunger (22) can be discharged through the air release groove (303); The top side wall of the second range pipette assembly (32) is provided with a radial guide groove (304) in communication with the pipeline (301), and the gas squeezed out by the side plunger (22) can enter the pipeline (301) through the radial guide groove (304).

3. The liquid transfer module according to claim 1, characterized in that: The number of the side plungers (22) is two, and the plurality of pipette assemblies (3) are specifically third-range pipette assemblies (33). The top side wall of the third-range pipette assembly (33) is provided with an air discharge groove (303) and a radial guide groove (304). The gas squeezed out by one of the side plungers (22) can be discharged through the air discharge groove (303), and the gas squeezed out by the other side plunger (22) can enter the pipeline (301) through the radial guide groove (304).

4. The liquid transfer module according to any one of claims 1 to 3, characterized in that: The pipette assembly (3) comprises a body (305), a pipette (306) passing through the body (305), and a flange (307) connecting the body (305) and the pipette (306); the pipette (306) is provided with the pipeline (301) and the passage (302); the top of the pipette (306) is located above the flange (307) and is arranged in the liquid aspiration cavity (1).

5. The liquid transfer module according to claim 4, characterized in that: The pipette (306) is provided with a limiting ring groove (308), and the side wall of the liquid aspiration cavity (1) is provided with a mounting groove (12) located on one side of the limiting ring groove (308) and connected to the limiting ring groove (308), and a limiting column rod (13) is slidably provided in the mounting groove (12); When the limiting column (13) is fixed to the mounting groove (12) under the action of a pre-tightening force, the limiting column (13) and the limiting ring groove (308) are engaged with each other so that the pipette assembly (3) is fixed to the liquid aspiration cavity (1); When the limiting column rod (13) slides in the installation groove (12) by overcoming the pre-tightening force, the limiting column rod (13) and the limiting ring groove (308) are disengaged from each other, so that the pipette assembly (3) and the liquid aspiration cavity (1) are disconnected.

6. The liquid transfer module according to any one of claims 1 to 3, characterized in that: All the plungers (2) are sleeved with a sealing ring (4) located in the liquid suction cavity (1); the liquid suction cavity (1) is provided with a groove (14) located above the sealing ring (4) and below the top of the plunger (2); the groove (14) is filled with a sealing locking piece (5) for spacing any two adjacent plungers (2); the sealing locking piece (5) can prevent the sealing ring (4) from moving with the plunger (2).

7. The liquid transfer module according to any one of claims 1 to 3, characterized in that: The top of the plunger (2) is provided with an annular convex head (201) located above the liquid suction cavity (1); a driving block (6) is provided above the liquid suction cavity (1); the driving block (6) is provided with a receiving cavity (61) for receiving the annular convex head (201); a mounting through groove (62) is provided on the bottom end surface of the receiving cavity (61) so as to connect the plunger (2) and the driving block (6); A quick-locking block (7) is slidably disposed in the accommodating cavity (61), and the upper and lower end surfaces of the quick-locking block (7) respectively abut against the upper and lower inner walls of the accommodating cavity (61). A positioning through groove (71) is disposed on the bottom end surface of the quick-locking block (7), and the positioning through groove (71) and the annular protrusion (201) are in contact with each other.

8. The liquid transfer module according to any one of claims 1 to 3, characterized in that: It also comprises a liquid suction drive (8) and a liquid transfer drive (9) which can be independently operated and arranged side by side, the output end of the liquid suction drive (8) is connected to the plunger (2), the output end of the liquid transfer drive (9) is connected to a sliding block (91), the liquid suction cavity (1) is fixedly connected to a guide rail (92), the sliding block (91) and the guide rail (92) are slidably connected, and the output end of the liquid suction drive (8) and the output end of the liquid transfer drive (9) are arranged side by side; When the liquid suction drive (8) is in operation, the plunger (2) moves relative to the liquid suction chamber (1); when the liquid transfer drive (9) is in operation and the position of the sliding block (91) is fixed, the liquid suction chamber (1), the plunger (2), the liquid suction drive (8), the liquid transfer drive (9) and the guide rail (92) move synchronously.

9. A liquid transfer workstation, characterized in that: Comprising a pipetting module as described in any one of claims 1-8.

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