Blood coagulation analysis device and method for cleaning dispensing nozzle

Abstract

The present invention provides a blood coagulation analysis device and a method for cleaning a dispensing nozzle. A control device (500) of the blood coagulation analysis device is configured to set a cleaning condition of the first nozzle (11a) for each reagent combination, wherein the reagent combination represents a combination of a reagent dispensed last time and a reagent to be dispensed this time. The control device (500) of the blood coagulation analysis device is configured to obtain a reagent combination, and when a cleaning condition of the first nozzle (11a) is set for the obtained reagent combination, the first nozzle (11a) is cleaned according to the set cleaning condition.

Description

Technical Field

[0001] The present invention relates to a blood coagulation analysis device and a method for cleaning a dispensing nozzle. Background Art

[0002] Japanese Patent Application Publication No. 2017-96760 discloses an automatic analyzer that dispenses a sample and a reagent into a reaction container and optically measures changes in color tone and turbidity caused by the reaction between the sample and the reagent. The reaction container in which the measurement was performed is cleaned after the measurement and is also used in the next measurement.

[0003] Public Content

[0004] In the automatic analyzer described in Japanese Patent Publication No. 2017-96760, after the above-mentioned dispensing is performed, the nozzle (also referred to as a "probe" in a blood coagulation analyzer) used for dispensing is cleaned in a cleaning tank. In such a method, the management of the cleaning tank takes time. In addition, if the nozzle is always cleaned in the same way regardless of the state of the nozzle after dispensing, it is sometimes impossible to fully clean the nozzle. If the nozzle cannot be fully cleaned, the analysis accuracy may be reduced due to the influence of foreign matter attached to the nozzle. For example, if the nozzle in which the reagent was dispensed (the last dispensing) was not fully cleaned is used to perform the dispensing of other reagents (this dispensing), it is possible that contamination caused by the reagent dispensed last time (hereinafter also referred to as "contamination between reagents") may occur. Contamination between reagents reduces the analysis accuracy.

[0005] The present disclosure has been made to solve the above-mentioned problems, and an object of the present disclosure is to provide a blood coagulation analysis device and a method for cleaning a dispensing nozzle that can suppress contamination between reagents.

[0006] The blood coagulation analysis device involved in the first mode of the present disclosure is configured to perform analysis by reacting a specimen and a reagent in a reaction container, and the blood coagulation analysis device is equipped with a reagent port, a first dispensing device, and a control device. The reagent port is configured to be able to provide multiple reagents. The first dispensing device has a first nozzle and a first driving device. The first driving device is configured to move the first nozzle to change the position of the first nozzle. The first dispensing device is configured to suck a specified reagent from multiple reagents at the reagent port through the first nozzle, and dispense the sucked reagent from the first nozzle into the reaction container. The control device is configured to control the first dispensing device. The control device is configured to use the first nozzle to dispense the reagent by controlling the first dispensing device, and clean the first nozzle each time the reagent is dispensed. The control device is configured to be able to set the cleaning condition of the first nozzle for each reagent combination, and the reagent combination represents the combination of the reagent dispensed last time and the reagent to be dispensed this time. The control device is configured to acquire the reagent combination, and when a cleaning condition of the first nozzle is set for the acquired reagent combination, clean the first nozzle under the set cleaning condition.

[0007] A second aspect of the present disclosure is a method for cleaning a dispensing nozzle for dispensing a reagent in a blood coagulation analyzer that performs analysis by reacting a specimen and a reagent in a reaction container. The method includes first to third steps to be described below.

[0008] In the first step, the control device of the blood coagulation analyzer acquires, with respect to the dispensing nozzle, a reagent combination indicating a combination of a reagent dispensed last time and a reagent to be dispensed this time.

[0009] In the second step, the control device determines whether a cleaning condition for the dispensing nozzle is set in advance for the reagent combination acquired in the first step.

[0010] In the third step, when it is determined in the second step that the cleaning condition of the dispensing nozzle is preset for the reagent set, the control device cleans the dispensing nozzle under the cleaning condition preset for the reagent set.

[0011] Furthermore, the control device of the blood coagulation analyzer may be constituted by a single unit or by a plurality of divided units.

[0012] The above objects, features, aspects and advantages and other objects, features, aspects and advantages of the present invention will become more apparent from the following detailed description of the present invention when read in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1This is a diagram showing a configuration for carrying out transportation and disposal of a reaction container and stirring and measuring the content of the reaction container in the blood coagulation analyzer according to the embodiment of the present disclosure.

[0014] Figure 2 It is a diagram showing the configuration of a first dispensing device and a second dispensing device and peripheral devices thereof in the blood coagulation analysis device according to an embodiment of the present disclosure.

[0015] Figure 3 It is a top view of an analysis table provided in the blood coagulation analysis apparatus according to an embodiment of the present disclosure.

[0016] Figure 4 It is used to illustrate Figure 3 A diagram showing the structure of each arm.

[0017] Figure 5 It is a diagram showing a control system of the blood coagulation analysis device according to the embodiment of the present disclosure.

[0018] Figure 6 This is a diagram showing an example of probe cleaning information.

[0019] Figure 7 This is a flowchart showing a series of analysis procedures executed by the blood coagulation analysis apparatus according to the embodiment of the present disclosure.

[0020] Figure 8 It is shown that in the execution Figure 7 The flowchart of the control related to the washing of each of the first probe and the second probe performed during the analysis is shown.

[0021] Fig. 9 is shown with Figure 8 A flowchart of a modified example of control related to probe cleaning is shown.

[0022] Fig.10 It is a figure which shows an example of the washing condition input screen. DETAILED DESCRIPTION

[0023] Hereinafter, the embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. In addition, the same reference numerals are given to the same or corresponding parts in the drawings, and their description will not be repeated.

[0024] The blood coagulation analysis device (hereinafter also referred to as "analyzer") according to this embodiment is configured to dispense a sample and a reagent into a reaction container through a dispensing nozzle, and optically measure the reaction state in the reaction container. Hereinafter, the dispensing nozzle and the sample are respectively referred to as "probe" and "sample". Examples of the sample include blood components and urine. In this embodiment, a disposable test tube (for example, a disposable test tube described below) is used as the reaction container of the analysis device. Figure 3 and Figure 4 The test tubes 100, 100A, 100B shown in the figure) are used below. Figure 1 and Figure 2 The structure of the analysis device will be described.

[0025] Figure 1 This is a diagram showing a structure for carrying out transportation and disposal of a reaction container and stirring and measuring the contents of the reaction container in an analysis device.

[0026] Reference Figure 1 The analysis device includes a test tube supply device 110, a test tube transport device 120, a stirring device 200, a measuring device 300, and a test tube waste container 400. The test tube supply device 110 and the test tube transport device 120 involved in this embodiment are respectively equivalent to an example of the "supply device" and the "transport device" involved in the present disclosure. Hereinafter, the test tube supply device 110 and the test tube transport device 120 are respectively referred to as the "supply device 110" and the "transport device 120".

[0027] The analysis device further includes a sample dispensing port P1. The supply device 110 includes a test tube storage portion 111 (hereinafter referred to as "storage portion 111") and a supply mechanism 112. The storage portion 111 is configured to store a plurality of (for example, up to 1000) test tubes. The supply mechanism 112 is configured to supply the test tubes stored in the storage portion 111 to the sample dispensing port P1. The storage portion 111 and the supply mechanism 112 will be described in detail later (see Figure 3 ).

[0028] The sample dispensing port P1 (hereinafter also referred to as "port P1") is arranged so that it can be injected by a sample dispensing device 20 (see Figure 2 When a test tube is placed at port P1, the sample is dispensed into the test tube by the sample dispensing device 20.

[0029] The transport device 120 includes an arm 121 with a clamp (hereinafter referred to as "arm 121") and a drive device 122. The arm 121 has a clamp configured to hold a test tube. The arm 121 is configured to hold the test tube detachably by the clamp. The drive device 122 is configured to move the arm 121 (and thus the clamp) to change the position of the clamp. The details of the arm 121 and the drive device 122 will be described later (see Figure 3 and Figure 4 ).

[0030] The analysis device also includes a plurality of ports capable of transporting test tubes through the transport device 120, more specifically, a stirring port P2, a scattering port P3a, a colorimetric port P3b, and a discard port P4. Sensors for detecting the presence of test tubes (hereinafter also referred to as "port sensors") are respectively provided at the sample dispensing port P1, the stirring port P2, the scattering port P3a, the colorimetric port P3b, and the discard port P4.

[0031] The stirring port P2 is disposed at a stirring position of the stirring device 200. The stirring device 200 is configured to stir the contents of the test tube under predetermined conditions (for example, stirring speed and stirring time) when the test tube is placed at the stirring port P2.

[0032] The scattering port P3a and the colorimetric port P3b are respectively arranged at the measurement position of the measurement device 300. Hereinafter, the scattering port P3a and the colorimetric port P3b are respectively described as "photometric ports P3" except for the case where they are to be distinguished.

[0033] The measuring device 300 is configured to perform a predetermined measurement on the contents of the test tube. In this embodiment, the measuring device 300 is configured to include a light source and a light detector (neither of which is shown in the figure), irradiate the light of the light source to the contents of the test tube placed at any photometric port P3, and measure the reaction state in the test tube based on the change in the amount of light detected by the light detector. The measuring device 300 is configured to include a light source and a light detector for the scattering port P3a, and a light source and a light detector for the colorimetric port P3b. As the light source and the light detector for the scattering port P3a, a light emitting diode and a photodiode can be used respectively. The light detector for the scattering port P3a is configured to detect 90° scattered light (i.e., scattered light in a direction orthogonal to the irradiation direction of the light). As the light source and the light detector for the colorimetric port P3b, a halogen lamp and a photodiode can be used respectively. The measuring device 300 can also be configured to include a plurality of halogen lamps with different wavelengths, and one halogen lamp suitable for measurement is selected from these halogen lamps for use. The light detector for the colorimetric port P3b is configured to detect the amount of transmitted light.

[0034] The waste port P4 is configured to collect used test tubes. The waste port P4 is connected to a test tube waste container 400 (hereinafter referred to as “the waste container 400 ”) via a pipe, for example. When a test tube is put into the waste port P4 , the test tube is guided to the waste container 400 .

[0035] Figure 2 1 is a diagram showing the configuration of the reagent dispensing device 10 , the sample dispensing device 20 , and their peripheral devices in the analysis device.

[0036] Reference Figure 2The analysis device includes a reagent dispensing device 10, a sample dispensing device 20, a reagent cooling box 31, a sample rack 32, a cleaning water tank 40, a monitoring unit 40a, a first switching valve 41, a second switching valve 42, a cleaning water pump 43, a waste liquid tank 50, and a monitoring unit 50a. The reagent dispensing device 10 and the sample dispensing device 20 involved in this embodiment are respectively equivalent to an example of the "first dispensing device" and the "second dispensing device" involved in the present disclosure. Hereinafter, the reagent dispensing device 10 and the sample dispensing device 20 are respectively referred to as the "dispensing device 10" and the "dispensing device 20".

[0037] The reagent cold storage box 31 contains a reagent tray. A plurality of reagent containers are placed on the reagent tray. The plurality of reagent containers contain a plurality of reagents that are different for each reagent container. The reagent cold storage box 31 is configured to have a temperature regulating device for adjusting the temperature in the cold storage box and a temperature sensor for detecting the temperature in the cold storage box (neither of which are shown in the figure), and to keep the reagent tray (and thus the reagent) cold. The reagent cold storage box 31 may also have a stirring device for stirring each reagent container placed on the reagent tray.

[0038] The dispensing device 10 includes an arm 11 with a first probe (hereinafter referred to as "arm 11"), a first injection pump 12, a pressure sensor 12a, and a first drive device 13. The arm 11 is configured to have a first probe (first nozzle) at the front end of the arm body. The arm 11 is configured to have a temperature regulating device for adjusting the temperature of the first probe and a temperature sensor for detecting the temperature of the first probe (neither of which are shown in the figure), and is capable of maintaining the temperature of the first probe at a predetermined temperature. The first drive device 13 is configured to move the arm 11 (and thus the first probe) to change the position of the first probe. The details of the arm 11 and the first drive device 13 will be described later (see Figure 3 and Figure 4 ).

[0039] The analysis device further includes ports, more specifically, a reagent suction port P11, a detergent port P12, and a first cleaning port P13, to which the first probe can be moved by the first driving device 13. In addition, the first driving device 13 can also move the first probe to the above-mentioned photometric port P3 (i.e., Figure 1 Scattering port P3a and colorimetric port P3b as shown).

[0040] The reagent suction port P11 (hereinafter also referred to as "port P11") is configured to provide a variety of reagents. The port P11 in this embodiment is located above the reagent cold storage box 31 and is configured to guide the first probe to the reagent. The analytical device involved in this embodiment has a port P11 and is configured to change the reagent located directly below the port P11. The details will be described later. The reagent cold storage box 31 has a turntable (not shown) for rotating the reagent tray. When the turntable rotates, the position of the reagent container changes. When the first probe moves to the port P11, a specified reagent container among the multiple reagent containers placed on the reagent tray is configured directly below the port P11. The first probe can suck the reagent in the reagent container through the port P11. The port P11 involved in this embodiment is equivalent to an example of the "reagent port" involved in the present disclosure. In addition, the analytical device can also be provided with multiple reagent ports for each reagent. By preparing reagents at each reagent port, multiple reagents can be provided through multiple reagent ports.

[0041] The detergent port P12 is configured to be able to provide detergent. The detergent port P12 in this embodiment is an opening configured to guide the first probe toward the detergent. Detergent is prepared directly below the detergent port P12. The first probe can suck the detergent through the detergent port P12. The detergent can always be present directly below the detergent port P12, or a specified detergent can be delivered directly below the detergent port P12 when the first probe moves to the detergent port P12. The details will be described later. In this embodiment, the detergent port P12 is located above the reagent cooling box 31, and the detergent container is placed on the above-mentioned reagent tray. The detergent container is delivered to the bottom of the detergent port P12 using the turntable of the reagent cooling box 31. In addition, Figure 3 In the embodiment, the reagent suction port P11 and the detergent port P12 are shown at different positions, but the reagent suction port and the detergent port can also be configured at the same position. That is, it is also possible that one port (for example, port P11 or detergent port P12) functions as both the reagent suction port and the detergent port. Since the reagent container and the detergent container are placed on the reagent tray, any of the reagent container and the detergent container can be moved to the position directly below the above-mentioned port by rotating the turntable.

[0042] The first cleaning port P13 is configured to recover the used cleaning liquid (e.g., pure water and detergent). The first cleaning port P13 in this embodiment is an opening configured to guide the first probe to the waste liquid tank 50. The first cleaning port P13 is connected to the waste liquid tank 50, for example, via a pipe. The cleaning liquid ejected from the first probe to the first cleaning port P13 accumulates in the waste liquid tank 50. The monitoring unit 50a is configured to include a liquid level sensor for detecting the liquid level in the waste liquid tank 50 and a notification device (e.g., a light and an alarm) (neither of which are shown in the figure). The monitoring unit 50a is configured to notify the increase of waste liquid by sound and / or display when the liquid level in the waste liquid tank 50 exceeds a specified value.

[0043] The reagent suction port P11, the detergent port P12, and the first cleaning port P13 will be described in detail later (see Figure 3 ).

[0044] The first injection pump 12 is located between the cleaning water pump 43 and the arm 11 (including the first probe). The first probe of the arm 11 and the first injection pump 12 are connected to each other via a pipe 10a. The pipe 10a passes through the inside of the arm body and is connected to the first probe (for example, see the following description). Figure 4 ). A pressure sensor 12a is provided in the middle of the piping 10a. The first injection pump 12 is configured to include: a cylindrical cylinder, a plunger configured to be able to slide on the inner wall surface of the cylinder while reciprocating (moving up and down) in the cylinder, and an actuator (such as an electric motor) for driving the plunger (none of which is shown in the figure). The first injection pump 12 is configured to be able to adjust the suction pressure and discharge pressure of the first probe by driving control of the plunger. The pressure of the first probe is detected by the pressure sensor 12a.

[0045] The washing water tank 40 contains pure water (e.g., purified water). The monitoring unit 40a is configured to include a water level sensor for detecting the water level in the washing water tank 40 and a notification device (e.g., a light and an alarm) (neither of which is shown in the figure). The monitoring unit 40a is configured to notify the user of a decrease in the amount of water by sound and / or display when the water level in the washing water tank 40 is lower than a predetermined value.

[0046] The cleaning water pump 43 is configured to draw pure water from the cleaning water tank 40. The cleaning water pump 43 is configured to be able to supply the pure water contained in the cleaning water tank 40 to the first injection pump 12 and the arm 11 (and then to the first probe). The cleaning water pump 43 is connected to the first injection pump 12 via the piping 10b. A first switching valve 41 (for example, a solenoid valve) is provided in the middle of the piping 10b. In addition, the piping 10b has a branch portion B1 at a position closer to the cleaning water pump 43 side than the first switching valve 41. The piping 10c connected to the cleaning water tank 40 is connected to the branch portion B1. The piping 10c functions as a piping (so-called return piping) for returning the water drawn by the cleaning water pump 43 to the cleaning water tank 40. In addition, each of the piping 10a to 10c may also be a resin pipe.

[0047] The control device of the analysis device (for example, the control device described below) Figure 5 The control device 500 shown in the figure operates the cleaning water pump 43 to open the first switching valve 41 before dispensing using the dispensing device 10. As a result, the pure water in the cleaning water tank 40 is supplied to the arm 11 via the piping 10b, the first injection pump 12, and the piping 10a. Then, the control device closes the first switching valve 41 while the pure water is filled from the first switching valve 41 to the front end of the arm 11 (i.e., the opening of the first probe). The control device does not stop the cleaning water pump 43 even after closing the first switching valve 41, and the water drawn by the cleaning water pump 43 is returned to the cleaning water tank 40 through the piping 10c, thereby circulating. The dispensing device 10 performs dispensing in this state.

[0048] When the first probe is used for suction, the control device lowers the plunger of the first syringe pump 12 (i.e., moves in the direction of expanding the cylinder volume). Thus, suction pressure can be generated at the opening of the first probe to perform suction using the first probe. When the first probe is used for ejection, the control device raises the plunger of the first syringe pump 12 (i.e., moves in the direction of reducing the cylinder volume). Thus, ejection pressure can be generated at the opening of the first probe to perform ejection using the first probe. The first syringe pump 12 is configured to transmit the pressure (i.e., suction pressure and ejection pressure) generated according to the change in the cylinder volume to the first probe via the water filled as described above. In addition, when the water filled in the first probe contacts the reagent sucked out from the first probe, the reagent is sometimes diluted. In order to suppress the dilution of such a reagent, the dispensing device 10 can also be configured to suck a small amount of air using the first probe before sucking the reagent using the first probe. By forming a gap (e.g., a gap formed by air) between the water and the reagent, the dilution of the reagent can be suppressed.

[0049] The dispensing device 20 includes an arm 21 with a second probe (hereinafter referred to as "arm 21"), a second injection pump 22, a pressure sensor 22a, and a second drive device 23. The arm 21 is configured to have a second probe (second nozzle) at the front end of the arm body. The second drive device 23 is configured to move the arm 21 (and thus the second probe) to change the position of the second probe. The second probe of the arm 21 and the second injection pump 22 are connected to each other via a pipe 20a. A pressure sensor 22a is provided in the middle of the pipe 20a. The second injection pump 22 is connected to the cleaning water pump 43 via a pipe 20b. A second switching valve 42 (for example, a solenoid valve) is provided in the middle of the pipe 20b. The pipe 20b has a branch portion B2 at a position closer to the cleaning water pump 43 than the second switching valve 42. The branch portion B2 is connected to a pipe 20c connected to the cleaning water tank 40.

[0050] The arm 21, the second injection pump 22, the pressure sensor 22a, the second drive device 23, the piping 20a~20c, the branch part B2 and the second switching valve 42 respectively have the same structures as the above-mentioned arm 11, the first injection pump 12, the pressure sensor 12a, the first drive device 13, the piping 10a~10c, the branch part B1 and the first switching valve 41, so their detailed description is omitted.

[0051] The dispensing device 20 further includes a CTS (Closed Tube Sampling) mechanism 24. The CTS mechanism 24 is configured to drill a hole in the cover of the sample container described later using a piercer when the cover is provided. By drilling the cover of the sample container, the sample in the sample container can be sucked by the second probe.

[0052] The analysis device further includes ports, more specifically, a sample suction port P21, an S port P22, and a second cleaning port P23, to which the second probe can be moved by a second driving device 23. In addition, the second driving device 23 can also move the second probe to the sample dispensing port P1 ( Figure 1 ).

[0053] A plurality of sample containers are placed on the sample rack 32. The plurality of sample containers include, for example, a sample container holding blood components (e.g., plasma) and a sample container holding urine. The blood components and urine are equivalent to samples, respectively. The sample suction port P21 (hereinafter also referred to as "port P21") is configured to provide a plurality of samples. The port P21 in this embodiment is an opening located above the sample rack 32 and configured to guide the second probe to the sample. The analysis device involved in this embodiment is configured to have a port P21 and to be able to change the sample located directly below the port P21. The details will be described later. The sample rack 32 is movable and is configured to be able to change the position of the sample container. When the second probe moves to the port P21, a predetermined sample container among the plurality of sample containers placed on the sample rack 32 is arranged directly below the port P21. The second probe can suck the sample in the sample container through the port P21. The port P21 involved in this embodiment is equivalent to an example of the "specimen port" involved in the present disclosure. In addition, the analysis device can also be provided with a plurality of specimen ports for each specimen. By preparing samples at each sample port, a variety of samples can be provided through the plurality of sample ports.

[0054] The S port P22 is configured to include a plurality of ports. In this embodiment, the S port P22 includes: a plurality of detergent ports for providing a plurality of detergents, a plurality of diluent ports for providing a plurality of sample diluents (hereinafter also referred to as "diluents"), and a plurality of buffer ports for providing a plurality of sample buffers (hereinafter also referred to as "buffers"). Detergents are prepared directly below the detergent port, diluents are prepared directly below the diluent port, and buffers are prepared directly below the buffer port. The second probe can respectively draw detergents, diluents, and buffers through the detergent port, diluent port, and buffer port included in the S port P22.

[0055] The second cleaning port P23 is configured to recover the used cleaning liquid (e.g., pure water and detergent). The second cleaning port P23 in this embodiment is an opening configured to guide the second probe to the waste liquid tank 50. The second cleaning port P23 is connected to the waste liquid tank 50, for example, via a pipe. The cleaning liquid ejected from the second probe to the second cleaning port P23 is accumulated in the waste liquid tank 50.

[0056] The sample suction port P21, the S port P22, and the second cleaning port P23 will be described in detail later (see Figure 3 ).

[0057] Figure 3 FIG. 1 is a top view of an analysis table included in the analysis device according to this embodiment. Figure 3, three mutually orthogonal axes (X-axis, Y-axis, and Z-axis) are shown. Among the X-axis, Y-axis, and Z-axis, the X-axis represents the width direction of the analysis device, the Y-axis represents the depth direction of the analysis device, and the Z-axis represents the vertical direction (i.e., the up and down direction). The direction indicated by the arrow of the Z-axis is equivalent to "up", and the opposite direction is equivalent to "down (i.e., the direction of gravity)".

[0058] Reference Figure 1 and Figure 2 And refer to Figure 3 The storage section 111 stores a plurality of (for example, 500) test tubes 100. The user can replenish the test tubes 100 into the storage section 111 from the input port (not shown) of the storage section 111. The material of the test tube 100 is arbitrary, and in this embodiment, the test tube 100 made of acrylic is used. The supply mechanism 112 takes out the test tube 100 from the storage section 111 and supplies the test tube 100 one by one to the port P1. The conveying method of the supply mechanism 112 for conveying the test tube 100 is arbitrary, for example, it can be any method including a slide method (self-weight method), a conveyor belt method, a roller method, and a sliding method. The supply mechanism 112 receives the detection result of the port sensor of the port P1, and if the port P1 is idle, it supplies the next test tube 100 to the port P1. However, not limited to this case, the supply mechanism 112 can also be configured to be controlled in accordance with the control device 500 described later (refer to Figure 5 ) is indicated by supplying the test tube 100 to the port P1.

[0059] The arm 21 includes a second probe 21a and an arm body 21b. The second driving device 23 ( Figure 2 ) is composed of: a rotating shaft 23a connected to the arm body 21b, a rotating actuator (not shown) that rotates the rotating shaft 23a, and a lifting actuator (not shown) that moves the arm 21 up and down. When the rotating shaft 23a rotates, the arm 21 (and then the second probe 21a) rotates integrally with the rotating shaft 23a. Through the rotation of the rotating shaft 23a, the second probe 21a rotates around the rotating shaft 23a and moves in a manner that describes an arc-shaped track L2 on the XY plane. The second drive device 23 can move the second probe 21a to the port P1, port P21, S port P22 (more specifically, ports P22a to P22i) and the second cleaning port P23 respectively provided on the track L2. In the S port P22, ports P22a and P22b are detergent ports, ports P22c, P22d and P22e are buffer / diluent ports, ports P22f and P22g are diluent / normal plasma / deficient plasma ports, and ports P22h and P22i are normal plasma / deficient plasma ports.

[0060] Although in Figure 3 , but is loaded into (mounted on) a sample rack 32 ( Figure 2) is located below the port P21. The sample rack 32 is configured to movably hold the sample container, and before the sample is dispensed, the sample container to be dispensed is arranged directly below the port P21. In the sample rack 32, the mechanism for moving the sample container to be dispensed to directly below the port P21 may be either a rotating mechanism (for example, a turntable mechanism) or a sliding mechanism. The CTS mechanism 24 is located near the port P21, and is configured to drill a hole in the cover using a drill when the sample container to be dispensed is provided with a cover.

[0061] The reagent cold storage box 31 is located below the port P11 and the detergent port P12. A reagent tray 31a in which a plurality of reagent containers 1 and a plurality of detergent containers 1a are placed is accommodated in the reagent cold storage box 31. The plurality of detergent containers 1a contain a plurality of detergents that are different for each detergent container 1a. The reagent cold storage box 31 is constructed as follows: it includes a disc-shaped turntable and an actuator (e.g., an electric motor) that rotates the turntable (neither of which is shown in the figure). The reagent tray is fixed (e.g., latched) on the turntable, and when the turntable rotates, the positions of the reagent container 1 and the detergent container 1a are changed. The port P11 and the detergent port P12 are respectively located on the rotating track of the turntable. By driving the turntable, the reagent cold storage box 31 can arrange the reagent container 1 directly below the port P11 and arrange the detergent container 1a directly below the detergent port P12.

[0062] The arm 11 includes a first probe 11a and an arm body 11b. The first driving device 13 ( Figure 2 ) is composed of: a rotating shaft 13a connected to the arm body 11b, a rotating actuator (not shown) for rotating the rotating shaft 13a, and a lifting actuator (not shown) for vertically displacing the arm 11. When the rotating shaft 13a rotates, the arm 11 (and then the first probe 11a) rotates integrally with the rotating shaft 13a.

[0063] The arm 121 includes a clamp 121a and an arm body 121b. The clamp 121a may hold the test tube 100 in any manner. The clamp 121a may be a mechanical clamp, a magnetic clamp, or a vacuum clamp. Figure 1 ) includes: a rotating shaft 122a connected to the arm body 121b, a rotating actuator (not shown) for rotating the rotating shaft 122a, and a lifting actuator (not shown) for moving the arm 121 up and down. When the rotating shaft 122a rotates, the arm 121 (and thus the clamp 121a) rotates integrally with the rotating shaft 122a.

[0064] The rotation center of each of the rotating shaft 13a and the rotating shaft 122a is the same. The first probe 11a and the fixture 121a are respectively driven to rotate as described above, thereby moving in the XY plane in a manner of describing a circular track L1. The first driving device 13 can move the first probe 11a to each port arranged on the track L1. The driving device 122 can move the fixture 121a to each port arranged on the track L1. Port P1, stirring port P2, multiple scattering ports P3a, multiple colorimetric ports P3b, discard port P4, port P11, detergent port P12 and the first cleaning port P13 are provided on the track L1.

[0065] Figure 4 It is used to illustrate Figure 3 A diagram showing the configuration of arm 11 and arm 121. Figure 4 The X-axis, Y-axis, and Z-axis in Figure 3 The X-axis, Y-axis, and Z-axis correspond to each other.

[0066] Reference Figure 3 And refer to Figure 4 , the arm 11 and the arm 121 are arranged staggered in the vertical direction. In this embodiment, the arm 11 is arranged at a higher position than the arm 121. The first probe 11a is connected to the front end E1 of the arm body 11b, and the rotating shaft 13a is connected to the base end E2 of the arm body 11b. The first probe 11a has an opening OP at the front end. The lifting actuator (not shown) of the first drive device 13 moves the arm 11 and the rotating shaft 13a in the vertical direction as a whole, thereby shifting the arm 11 (and then the first probe 11a) up and down. For example, the first probe 11a moves in the vertical direction. Figure 4 The test tube 100B shown (ie, the test tube 100 placed at the scattering port P3a) descends to approach the test tube 100B when the reagent is dispensed, and when the reagent dispensing is completed, the first probe 11a ascends to leave the test tube 100B.

[0067] like Figure 4 As shown, the above-mentioned piping 10a (refer to Figure 2 ) is connected to the first probe 11a via pipes provided inside the rotating shaft 13a and the arm body 11b. The cleaning water pump 43 ( Figure 2 ) can supply the cleaning water tank 40 to the first probe 11a through such piping ( Figure 2 ) in the arm. In addition, the first syringe pump 12 can eject the liquid filled in the arm 11 (ie, the first probe 11a and the arm body 11b) from the opening OP of the first probe 11a by applying ejection pressure to the first probe 11a.

[0068] The clamp 121a is connected to the front end E3 of the arm body 121b, and the rotation shaft 122a is connected to the base end E4 of the arm body 121b. The base end E4 of the arm body 121b is held on the rotation shaft 122a in a manner that allows it to be displaced in the up-down direction. The lifting actuator (not shown) of the driving device 122 moves the arm 121 in the up-down direction, thereby displacing the arm 121 (and thus the clamp 121a) up-down. For example, the clamp 121a is used for conveying Figure 4 The arm 121 is rotated by the driving device 122, and the gripper 121a reaches the port (more specifically, the port) that is the destination of the transport. Figure 3 After the test tube 100a is placed on the port, the clamp 121a releases the test tube 100a (i.e., releases the clamp) and rises again.

[0069] Figure 5 2 is a diagram showing a control system of the analysis device according to this embodiment. Figure 5 The analysis device includes a control device 500. The control device 500 is configured to include a processor 510, a RAM (Random Access Memory) 520, a storage device 530, and an input / output buffer (not shown) for inputting and outputting various signals. As the processor 510, for example, a CPU (Central Processing Unit) can be used. The RAM 520 functions as a working memory for temporarily storing data processed by the processor 510. The storage device 530 is configured to be able to save written information. The storage device 530 includes, for example, a ROM (Read Only Memory) and a rewritable non-volatile memory. The storage device 530 may also include at least one of a hard disk drive and an SSD (solid state drive). In addition to pre-storing control programs used in various controls in the storage device 530, information used in the program (for example, various parameters) is also pre-stored. Various processes performed by the control device 500 can also be performed by dedicated hardware (electronic circuit) instead of software. The number and arrangement of processors included in the analysis device are arbitrary. A processor may be prepared for each predetermined control, or a plurality of processors may be mounted in a plurality of units.

[0070] The control device 500 is configured to control the dispensing device 10 (eg Figure 2The first injection pump 12 and the first driving device 13 shown in the figure), the dispensing device 20 (for example Figure 2 The second injection pump 22, the second drive device 23 and the CTS mechanism 24 shown in the figure), the first switching valve 41, the second switching valve 42, the cleaning water pump 43, the conveying device 120 (for example Figure 1 and Figure 4 The fixture 121a and driving device 122) and the measuring device 300 are shown.

[0071] The analysis device includes a sensor 503 for detecting the state of the analysis device. Output signals of various sensors included in the sensor 503 (i.e., signals indicating the detection results) are input to the control device 500. In this embodiment, the sensor 503 includes pressure sensors 12a, 22a ( Figure 2 ), temperature sensors of the first probe and the second probe (not shown) and sensors of each port (not shown).

[0072] The analysis device further includes an input device 501 and a notification device 504. The input device 501 is a device for receiving input from a user. The input device 501 is operated by a user and outputs a signal corresponding to the user's operation to the control device 500. The notification device 504 is configured to perform a specified notification process to the user when there is a request from the control device 500. In this embodiment, a touch panel display integrating the input device 501 and the notification device 504 is used. However, it is not limited to this, and the input device 501 and the notification device 504 can also be prepared separately. For example, various pointing devices (mouse, touch pad, etc.), keyboards, etc. can also be used as the input device 501. In addition, the input device 501 can also be an operating unit of a portable device (such as a smart phone). In addition, the notification process performed to the user is an arbitrary process, and the notification can be performed by displaying on a display device (such as display of text or images), or by using a speaker to notify with sound (including voice), or by lighting a specified light (including flashing).

[0073] In this embodiment, a label 32a is provided for each sample container placed on the sample rack 32. The analysis device also includes a reader 502 that reads information from the label 32a. The reader 502 is configured to output information obtained from the label 32a to the control device 500. The label 32a is configured to provide information of the sample in the sample container (for example, sample ID and analysis items, etc.). The label 32a displays a specified code (for example, a QR code (registered trademark)). However, it is not limited to this, and the label 32a can be an IC tag or can be configured to send sample information using radio waves. The reading method of the reader 502 can be either a non-contact method or a contact method. As the reader 502 that reads the code displayed on the label 32a, a well-known code reader can also be used. The reader 502 can be fixed at a position where the label 32a can be read, or it can be a movable reader controlled by the control device 500.

[0074] The reagent cooling box 31 ( Figure 2 ) in the reagent tray (e.g., reagent ID, reagent type, and expiration date, etc.). The reagent information may also be registered in the control device 500 by the user. However, it is not limited thereto, and it may also be configured as follows: a label is provided for each reagent container, a reader is provided on the reagent tray, and the control device 500 controls the reader to read the reagent information from the label. In such a structure, the information of each reagent placed on the reagent tray is automatically registered in the control device 500. The registered reagent information is stored in the storage device 530. The reagent information is managed by each reagent ID (and then by each reagent container).

[0075] The analysis device analyzes multiple samples simultaneously. For example, the analysis device performs measurement preparation for a certain sample (for example, dispensing at port P11 or P21) while performing measurement of other samples (more specifically, optical measurement at photometric port P3). In order to efficiently analyze all the samples that have been reserved, the analysis device determines the analysis schedule for each sample based on sample information (for example, analysis items of each sample) and the idle status of each port, and performs analysis according to the analysis schedule. The analysis schedule includes, for example, the timing of dispensing and the timing of measurement, the sample and reagent that are the objects of dispensing, and the photometric port P3 for measurement. The analysis schedule is stored in the storage device 530. The analysis schedule is managed for each sample ID (and thus for each sample container).

[0076] When the analysis starts, an ID (test tube ID) is assigned to the test tube used in the analysis. Then, when the analysis is performed, the analysis history records including those passed in the middle are saved in the storage device 530. The analysis history records are updated sequentially as the analysis proceeds. The analysis history records include, for example, the movement path of the test tube (including the current position), the sample and reagent dispensed into the test tube, the photometric port P3 where the measurement was performed, and the measurement results. The analysis history records are managed for each test tube ID (and thus for each test tube). The control device 500 and the user can each confirm whether the analysis has been performed (progress has been made) according to the analysis schedule by referring to the analysis history records.

[0077] The control device 500 controls the movable sample rack 32 while referring to the analysis schedule and reagent information to arrange the specified sample (i.e., the sample to be dispensed) directly below the port P21, and controls the actuator for driving the turntable of the reagent cold storage box 31 to arrange the specified reagent (i.e., the reagent to be dispensed) directly below the port P11. The temperature of the first probe 11a is adjusted according to the ambient temperature of the analysis device (e.g., the temperature of the room where the analysis device is placed). For example, when the ambient temperature of the analysis device is low, the temperature of the first probe 11a is increased. Whenever the control device 500 uses a probe (i.e., the first probe 11a or the second probe 21a) for dispensing, the probe that has been dispensed is cleaned.

[0078] In addition, if the probe is not fully cleaned, the analysis accuracy may be reduced due to the influence of foreign matter attached to the probe. For example, if the probe that has been dispensed (last dispensing) of a reagent is used to dispense other reagents (this dispensing) without being fully cleaned, contamination caused by the reagent dispensed last time (i.e., inter-reagent contamination) may occur. Inter-reagent contamination reduces the analysis accuracy. Therefore, the analysis device involved in this embodiment suppresses inter-reagent contamination by having a structure to be described below.

[0079] In the analysis device involved in this embodiment, the control device 500 is configured to set the cleaning condition (hereinafter referred to as the "first cleaning condition") for the first probe 11a according to each combination of the reagent dispensed last time and the reagent to be dispensed this time. Hereinafter, the combination of the reagent dispensed last time by the first probe 11a and the reagent to be dispensed this time by the first probe 11a is referred to as the "reagent combination". In addition, the control device 500 is configured to set the cleaning condition (hereinafter referred to as the "second cleaning condition") for the second probe 21a according to each combination of the sample dispensed last time and the sample to be dispensed this time. Hereinafter, the combination of the sample dispensed last time by the second probe 21a and the sample to be dispensed this time by the second probe 21a is referred to as the "specimen combination". The first cleaning condition and the second cleaning condition are respectively equivalent to the cleaning condition of the first probe 11a and the cleaning condition of the second probe 21a.

[0080] The user can set the first cleaning condition and the second cleaning condition in the control device 500 through the input device 501 (e.g., a touch panel). When the first cleaning condition and the second cleaning condition are set in the control device 500, information indicating the first cleaning condition and the second cleaning condition (hereinafter referred to as "probe cleaning information") is stored in the storage device 530. The first cleaning condition and the second cleaning condition are conditions for cleaning performed during analysis, respectively, and are different from the conditions for cleaning performed when the analysis device is started (e.g., when the power is turned on) and when the analysis device is stopped (e.g., when the power is turned off).

[0081] When the control device 500 performs dispensing using the first probe 11a or the second probe 21a (equivalent to the dispensing of the above-mentioned "last dispensing"), before performing the next dispensing using the probe (equivalent to the dispensing of the above-mentioned "this dispensing"), the probe is cleaned using a prescribed cleaning liquid (for example, the cleaning liquid shown in the first cleaning condition or the second cleaning condition). The control device 500 fills the cleaning liquid into the probe that has been dispensed, and sprays the filled cleaning liquid from the probe, thereby cleaning the probe. The control device 500 can perform multiple cleanings by repeatedly filling and spraying the cleaning liquid. In this embodiment, pure water and detergent are used as cleaning liquids. The control device 500 is configured to perform pure water-based cleaning (hereinafter also referred to as "pure water cleaning") and detergent-based cleaning (hereinafter also referred to as "detergent cleaning") in the manner to be described below.

[0082] When using pure water to clean the probe (the first probe 11a or the second probe 21a), the control device 500 controls the injection pump (the first injection pump 12 or the second injection pump 22) to supply and fill the probe with pure water (i.e., pure water previously supplied to the injection pump and the arm body from the cleaning water tank 40 by the cleaning water pump 43) filled in the injection pump and the arm body, and ejects the filled pure water from the probe to the cleaning port (the first cleaning port P13 or the second cleaning port P23) at a specified ejection pressure. Hereinafter, the above-mentioned specified ejection pressure is referred to as the "ejection pressure during pure water cleaning". Thereafter, the control device 500 controls the switching valve (the first switching valve 41 or the second switching valve 42) and the cleaning water pump 43 to supply the amount of pure water that is insufficient due to the above-mentioned ejection from the cleaning water tank 40 to the injection pump and the arm (arm 11 or 21).

[0083] When the probe (the first probe 11a or the second probe 21a) is cleaned with detergent, the control device 500 controls the injection pump (the first injection pump 12 or the second injection pump 22), thereby filling the probe with detergent by causing the probe to suck the detergent provided by the detergent port (ports P22a, P22b or detergent port P12), and after holding for a specified time, the filled detergent is ejected from the probe to the cleaning port (the first cleaning port P13 or the second cleaning port P23) at a specified ejection pressure. Hereinafter, the above-mentioned specified time and the above-mentioned specified ejection pressure are respectively referred to as "holding time" and "ejection pressure during detergent cleaning". Thereafter, the control device 500 supplies pure water from the cleaning water tank 40 to the injection pump and the arm (arm 11 or 21) by controlling the switching valve (the first switching valve 41 or the second switching valve 42) and the cleaning water pump 43, thereby flushing away the detergent attached to the probe and filling the injection pump and the arm with pure water. The action of flushing out the detergent may be always the same, or may be changed according to the type of detergent.

[0084] Alternatively, the ejection pressures during pure water cleaning and detergent cleaning may be variable depending on the situation, but in this embodiment, the ejection pressure is set to a fixed value (e.g., the maximum pressure that can be set). The ejection volume each time corresponds to the ejection pressure, and the higher the ejection pressure, the greater the ejection volume.

[0085] In this embodiment, the first cleaning condition and the second cleaning condition that can be set in the control device 500 include the type of cleaning liquid, the number of cleaning times, and the holding time. The types of cleaning liquid that can be set in the control device 500 include pure water and detergent. The number of cleaning times is the number of times the filling and spraying of the cleaning liquid are repeated. The holding time is the time from the probe sucking the detergent to the detergent spraying.

[0086] The probe cleaning information in the storage device 530 indicates the first cleaning condition and the second cleaning condition set in the control device 500 . Figure 6 FIG. 1 is a diagram showing an example of probe cleaning information. Figure 6 In the above, reagents X1, X2 and X3 are reagents of different types, and detergents Y1, Y2 and Y3 are detergents of different types. Hereinafter, the reagent dispensed by the first probe 11a last time is referred to as the "last reagent", the reagent to be dispensed by the first probe 11a this time is referred to as the "current reagent", the sample dispensed by the second probe 21a last time is referred to as the "last sample", and the sample to be dispensed by the second probe 21a this time is referred to as the "current sample".

[0087] Reference Figure 6 , the probe cleaning information indicates the cleaning conditions as described below. Under the cleaning conditions when the last reagent and the reagent this time are both reagent X1, the cleaning liquid is pure water, and the number of cleanings is twice. Under the cleaning conditions when the last reagent was reagent X1 and the reagent this time is reagent X3, the cleaning liquid is detergent Y1, the number of cleanings is once, and the holding time is five seconds. Under the cleaning conditions when the last reagent was reagent X2 and the reagent this time is reagent X3, the cleaning liquid is detergent Y1, the number of cleanings is twice, and the holding time is one second. Under the cleaning conditions when the last reagent was reagent X3 and the reagent this time is other than reagent X3, the cleaning liquid is detergent Y2, the number of cleanings is five times, and the holding time is one second.

[0088] Under the cleaning conditions when the last reagent was AT3 (antithrombin III)-1 and the reagent this time was APTT reagent, the cleaning liquid was an alkaline detergent, the number of cleanings was once, and the holding time was one second. Under the cleaning conditions when the last reagent was AT3-1 and the reagent this time was CaCl2 (calcium chloride), the cleaning liquid was an alkaline detergent, the number of cleanings was once, and the holding time was one second. Under the cleaning conditions when the last reagent was AT3-1 and the reagent this time was PT reagent, the cleaning liquid was an alkaline detergent, the number of cleanings was once, and the holding time was one second. Under the cleaning conditions when the last reagent was Fbg (fibrinogen) and the reagent this time was PT reagent, APTT reagent or CaCl2, the cleaning liquid was an alkaline detergent, the number of cleanings was three times, and the holding time was one second. In addition, APTT (activated partial thromboplastin time) reagent is a reagent containing an active substance (foreign component) such as ellagic acid. PT (prothrombin time) reagent is a reagent containing tissue factor (TF: tissue factor), for example. AT3-1 refers to the first reagent of the two reagents used in the measurement of AT3. In addition, the first reagent of the two reagents used in the measurement of APTT is APTT, and the second reagent is CaCl2. If APTT or CaCl2 is dispensed into the test tube immediately after the AT3-1 reagent is dispensed and contamination occurs, the coagulation reaction of APTT performed in the test tube will be affected by the AT3-1 reagent.

[0089] Under the cleaning conditions when the previous sample was a blood component (e.g., plasma) and the current sample was urine, the cleaning liquid was pure water and the number of cleanings was three times. Under the cleaning conditions when the previous sample was urine and the current sample was a blood component (e.g., plasma), the cleaning liquid was detergent Y3, the number of cleanings was two times, and the holding time was one second.

[0090] Since the cleaning power of detergent is stronger than that of pure water, detergent cleaning is easier to remove the attachments of the probe than pure water cleaning. In addition, there is the following tendency: the longer the holding time in detergent cleaning, the easier it is to remove the attachments of the probe. In addition, there is the following tendency: the more times of cleaning, the higher the cleanliness of the probe. On the other hand, compared with detergent cleaning, pure water cleaning can be performed more simply. In addition, if the holding time is extended or the number of cleanings is increased, the cleaning process becomes complicated or the cleaning time becomes longer. Therefore, in the analytical device involved in this embodiment, the cleaning solution, the number of cleanings and the holding time are changed according to the reagent combination and the specimen combination.

[0091] exist Figure 6In the probe cleaning information shown, when the previous reagent is the same as the current reagent (i.e., when reagent contamination is not likely to occur), the probe is cleaned with pure water, and when the previous reagent is different from the current reagent (i.e., when reagent contamination is likely to occur), the probe is cleaned with detergent. Probe stains caused by plasma are easily washed off even with pure water, so when the previous sample was plasma and the current sample was urine, the probe is cleaned with pure water. Figure 6 In the probe cleaning information shown, the cleaning conditions (more specifically, the cleaning solution, the number of cleaning times, and the holding time) are changed according to the reagent combination and the sample combination to achieve the appropriateness of the cleaning degree. In this way, excessive cleaning can be suppressed and contamination of the probe can be suppressed.

[0092] The control device 500 is configured to obtain a reagent combination, and when a first cleaning condition is set for the obtained reagent combination, the first probe 11a is cleaned with the set first cleaning condition. In addition, the control device 500 is configured to obtain a sample combination, and when a second cleaning condition is set for the obtained sample combination, the second probe 21a is cleaned with the set second cleaning condition.

[0093] The control device 500 is configured to clean the probe (first probe 11a or second probe 21a) under specified standard conditions when no cleaning conditions (first cleaning conditions or second cleaning conditions) are set for the acquired combination (reagent combination or sample combination). In the cleaning of the first probe 11a and the cleaning of the second probe 21a, different standard conditions can be set or common standard conditions can be set. In this embodiment, common standard conditions are used. The standard conditions are stored in the storage device 530. Although the standard conditions can be set arbitrarily, under the standard conditions involved in this embodiment, the cleaning liquid is pure water and the number of cleaning times is once.

[0094] Figure 7 1 is a flowchart showing a series of analysis processes performed by the analysis device involved in this embodiment. The control device 500 performs the analysis according to the above-mentioned analysis schedule. In addition, each time Figure 7 When the processing steps shown are performed, the above-mentioned analysis history record is updated.

[0095] Main reference Figure 3 and Figure 7 In step (hereinafter referred to as "S") 1, the supply mechanism 112 takes out the test tube 100 from the storage portion 111 and supplies one test tube 100 to the port P1. If the supply mechanism 112 knows that the port P1 is idle based on the output of the port sensor of the port P1, it supplies the next test tube 100 to the port P1.

[0096] In S2, the sample is dispensed into the test tube 100. More specifically, the control device 500 controls the movable sample rack 32 ( Figure 2 ) to place the specified sample (more specifically, the sample specified by the analysis schedule) directly below the port P21. Next, the control device 500 controls the second drive device 23 ( Figure 2 ) to move the second probe 21a to the port P21, and use the second probe 21a to suck the sample. Next, the control device 500 controls the second drive device 23 ( Figure 2 ) to move the second probe 21a to the port P1, and dispense the sample from the second probe 21a into the test tube 100 (more specifically, the test tube 100 supplied to the port P1 in S1). Figure 8 The second probe 21a is cleaned by the treatment.

[0097] In S3, the test tube 100 is transported to the photometric port P3 for heating. Specifically, the control device 500 controls the driving device 122 ( Figure 1 ), the test tube 100 is transported from port P1 to photometry port P3 using arm 121.

[0098] In S4, the test tube 100 is transported to the stirring port P2. Specifically, the control device 500 controls the driving device 122 ( Figure 1 ), the test tube 100 is transported from the photometric port P3 to the stirring port P2 by the arm 121. However, when the analysis item is a coagulation item, S4 and S6 described later are omitted. In this case, in S5 described later, the test tube 100 located at the photometric port P3 is dispensed, and stirring after the dispensing is not performed. The contents of the test tube 100 are mixed by the momentum of the reagent ejection in S5.

[0099] In S5, the reagent is dispensed. Specifically, the control device 500 controls the actuator for driving the turntable of the reagent cold storage box 31 to place the specified reagent (more specifically, the reagent specified by the analysis schedule) directly below the port P11. Next, the control device 500 controls the first drive device 13 ( Figure 2 ) to move the first probe 11a to the port P11, and the first probe 11a is used to suck the reagent. Next, the control device 500 controls the first drive device 13 ( Figure 2 ) to move the first probe 11a to the stirring port P2, and the reagent is dispensed from the first probe 11a into the test tube 100. After the dispensing, the contents of the test tube 100 are stirred by the stirring device 200. In addition, after the dispensing, the reagent is dispensed by the stirring device 200 described below. Figure 8 The first probe 11a is cleaned by the treatment.

[0100] After the dispensing of the reagents is completed, in S6, the test tube 100 is transported to the photometric port P3. In the case where the analysis item is a colorimetric item of two reagents, the above-mentioned processes of S3 to S5 are repeated to perform the dispensing of the first reagent and the second reagent. For example, in S3, the test tube 100 is placed on the scattering port P3a and heated, and after the dispensing of all the reagents is completed, in S6, the test tube 100 is transported to the colorimetric port P3b. Thereafter, in S7, the control device 500 controls the measuring device 300 to perform the measurement to be described below.

[0101] For example, when the sample is plasma and the analysis item is coagulation, the coagulation time of the sample is measured at the scattering port P3a. As coagulation proceeds, the intensity of scattered light increases, and when the coagulation reaction is completed, the intensity of scattered light hardly changes, so the coagulation time can be obtained based on the intensity of scattered light.

[0102] When the sample is plasma and the analysis item is a colorimetric item, the concentration and activity value of the sample are measured at the colorimetric port P3b. After the sample is placed in the test tube 100 and a prescribed time has passed, the first reagent is dispensed into the test tube 100, and then, after a prescribed time has passed since the first reagent was dispensed, the second reagent (more specifically, a reagent different from the first reagent) is dispensed into the test tube 100. By placing the second reagent in the test tube 100, the sample and the reagent begin to react, and the absorbance of the contents of the test tube 100 changes. The concentration and activity value of the sample can be determined based on this shift in absorbance. In such a measurement, after the first reagent and the second reagent are dispensed, the following method is used to determine the concentration and activity value of the sample. Figure 8 The first probe 11a is cleaned by the treatment.

[0103] When the sample is urine, for example, a change in absorbance due to a reaction between the sample and the reagent is optically measured at the colorimetric port P3b.

[0104] When the above measurement is completed, in S8, the control device 500 controls the driving device 122 ( Figure 1 ), the test tube 100 is transported from the photometric port P3 to the waste port P4 by the arm 121, and the grip of the arm 121 is released to put the test tube 100 into the waste port P4. When the test tube 100 is put into the waste port P4, the test tube 100 (i.e., the used reaction container) is recovered into the waste container 400 ( Figure 1 )middle.

[0105] Figure 8 11a and 21a. When dispensing is performed using either the first probe 11a or the second probe 21a, the control device 500 executes Figure 8 processing.

[0106] Main reference Figure 8 In S11, the control device 500 refers to the analysis schedule in the storage device 530 to obtain the combination of the component dispensed by the probe last time (i.e., the component dispensed previously) and the component to be dispensed by the probe this time (i.e., the component to be dispensed next). For example, in the cleaning of the first probe 11a, the control device 500 obtains the reagent combination. In addition, in the cleaning of the second probe 21a, the control device 500 obtains the specimen combination. The control device 500 can also obtain the component dispensed last time (the last reagent or the last sample) from the analysis history record.

[0107] In S12, the control device 500 refers to the probe cleaning information ( Figure 5 ) to determine whether the combination obtained in the above S11 has been registered in the probe cleaning information.

[0108] When the combination acquired in S11 has been registered in the probe cleaning information ("Yes" in S12), in S13, the control device 500 cleans the probe (the first probe 11a or the second probe 21a) according to the cleaning conditions indicated by the probe cleaning information. More specifically, the above-mentioned pure water cleaning or detergent cleaning is performed. In addition, the fact that the combination acquired in S11 has been registered in the probe cleaning information means that a cleaning condition (the first cleaning condition or the second cleaning condition) is set in advance for the combination (reagent combination or sample combination) acquired in S11.

[0109] On the other hand, when the combination acquired in S11 is not registered in the probe cleaning information (No in S12), in S10, the control device 500 performs the operation according to the standard condition ( Figure 5 ) to clean the probe (first probe 11a or second probe 21a). More specifically, for example, a pure water cleaning is performed once. In addition, the combination obtained in the above S11 is not registered in the probe cleaning information, which means that no cleaning condition (first cleaning condition or second cleaning condition) is pre-set for the combination (reagent combination or sample combination) obtained in the above S11.

[0110] S11 , S12 , and S13 according to this embodiment correspond to examples of the “first step,” “second step,” and “third step,” respectively, according to the present disclosure.

[0111] [Modifications]

[0112] In the above embodiment, before cleaning the probe (the first probe 11a or the second probe 21a), the control device 500 obtains the reagent combination or the sample combination ( Figure 8In S11), when no cleaning condition of the probe is set for the acquired combination (in Figure 8 The probe is cleaned under the specified standard conditions ( Figure 8 S10 of FIG. 5 ). However, the control device 500 is not limited thereto. The control device 500 may also be configured to request the user to set the cleaning condition when the cleaning condition of the probe is not set for the acquired combination (reagent combination or sample combination).

[0113] Fig. 9 is shown with Figure 8 The control device 500 may also be configured to execute Fig. 9 Instead of processing Figure 8 In addition, Fig. 9 S11~S13 of Figure 8 S11~S13 are the same.

[0114] Reference Figure 5 And refer to Fig. 9 In this modification, when the combination acquired in S11 is not registered in the probe cleaning information ("No" in S12), in S131, the control device 500 causes the notification device 504 (e.g., a touch panel display) to display a cleaning condition input screen to request the user to set the cleaning condition. In S132, the control device 500 determines whether the cleaning condition is set by the user. During the period before the user sets the cleaning condition (the period determined as "No" in S132), S131 and S132 are repeated.

[0115] Fig.10 2 is a diagram showing an example of a cleaning condition input screen. Fig.10 , the cleaning condition input screen displays a table M1, a message M2, and a confirmation button M3. Table M1 shows the reagent combination that is not set in the control device 500 (last reagent: reagent X5, this reagent: reagent X1) and the cleaning conditions that can be set in the control device 500 (input item M10). Message M2 includes instructions related to the cleaning condition input screen and a message prompting the user to set the cleaning conditions. The user can set the cleaning conditions in the control device 500 by operating the input device 501 (such as a touch panel). For example, when the user touches an item of the cleaning condition in table M1 in the cleaning condition input screen (input item M10), an option or a keypad for the cleaning conditions is displayed on the screen, allowing the user to enter the cleaning conditions. After entering the cleaning conditions, when the user presses the confirmation button M3, the input cleaning conditions are set in the control device 500 (and then registered in the probe cleaning information), and Fig. 9 The judgment in S132 is "yes". Fig. 9In S13, the probe is cleaned under the cleaning conditions set as described above.

[0116] Furthermore, the control device 500 may be configured to execute a first mode (for example, executing a first mode) of cleaning the probe under predetermined standard conditions when no cleaning conditions for the probe are set for the reagent combination or the sample combination. Figure 8 and a second mode requiring the user to set the cleaning conditions (e.g., Fig. 9 The control device 500 may be configured to execute the first mode or the second mode set by the user. Such a control device 500 receives input from the user and executes either the first mode or the second mode according to the input from the user (i.e., mode setting). The user can switch the mode as needed to make the control device 500 execute the mode that suits the situation.

[0117] The control device 500 may also be configured to, when the analysis schedule is referred to before the start of analysis and a reagent combination or a sample combination for which the washing conditions are not set in the control device 500 is to be dispensed during the analysis, display a washing condition input screen (e.g., referring to the washing condition input screen) before the start of analysis. Fig.10 ) to ask the user to set the cleaning conditions.

[0118] The cleaning conditions of the probe that can be set in the control device 500 are not limited to Figure 6 The conditions shown can be changed appropriately. For example, the holding time can be set to a fixed value so that the holding time is not included in the settable cleaning conditions. In addition, pure water cleaning and detergent cleaning can be arbitrarily combined to perform cleaning under more complex conditions, such as performing a pure water cleaning after a first detergent cleaning, and then performing a second detergent cleaning (for example, a detergent cleaning performed using a detergent different from the first detergent cleaning).

[0119] The structures of the devices of the blood coagulation analyzer (for example, the test tube supply device 110, the test tube transport device 120, the measuring device 300, and the dispensing devices 10 and 20) and the arrangement of the ports are not limited to Figure 3 and Figure 4 The structure and configuration shown can be changed appropriately. For example, the CTS mechanism 24 can be omitted appropriately. In addition, in order to suppress the mixing of foreign matter into the port, a cover (for example, a sliding cover) that can be opened and closed can be provided at least one of the reagent port, the specimen port, and the detergent port, and the cover is opened only when in use.

[0120] The number of probes (dispensing nozzles) is arbitrary. One arm (e.g., arm 11) may also have two or more nozzles (first nozzles) for dispensing reagents. One arm (e.g., arm 21) may also have two or more nozzles (second nozzles) for dispensing specimens. In a structure in which one arm has two or more dispensing nozzles, information is managed for each dispensing nozzle, and cleaning conditions are set for each dispensing nozzle.

[0121] The number of ports can also be changed appropriately. For example, in the above-mentioned embodiment, cleaning ports (first cleaning port P13 and second cleaning port P23) are prepared for the first nozzle and the second nozzle, respectively, but a common cleaning port can also be prepared for the first nozzle and the second nozzle. In addition, in the above-mentioned embodiment, a plurality of photometric ports P3 are prepared on the analysis table, but the number of photometric ports P3 can also be one. The blood coagulation analysis device can also be configured to sequentially transport the reaction containers prepared for the measurement to the photometric port P3. The arm for transporting the reaction container (for example, the arm 121 with a clamp) can also be omitted, and the reaction container can be transported by a conveyor belt. The reaction container is not limited to a disposable test tube made of acrylic acid, and any container can be used as the reaction container.

[0122] In the above-mentioned embodiment, a blood coagulation analyzer that analyzes a plurality of specimens (blood components and urine) is exemplified. However, the blood coagulation analyzer may analyze only one specimen (for example, blood components).

[0123] [Way]

[0124] It will be understood by those skilled in the art that the above-described multiple exemplary embodiments and their modifications are specific examples of the following aspects.

[0125] (Item 1) A blood coagulation analysis device according to one embodiment is configured to perform analysis by reacting a specimen and a reagent in a reaction container, and the blood coagulation analysis device comprises a reagent port, a first dispensing device, and a control device. The reagent port is configured to provide a plurality of reagents. The first dispensing device comprises a first nozzle and a first driving device. The first driving device is configured to move the first nozzle to change the position of the first nozzle. The first dispensing device is configured to suck a prescribed reagent from a plurality of reagents at the reagent port through the first nozzle, and dispense the sucked reagent from the first nozzle into the reaction container. The control device is configured to control the first dispensing device. The control device is configured to dispense the reagent using the first nozzle by controlling the first dispensing device, and to clean the first nozzle each time the reagent is dispensed. The control device is configured to be able to set the cleaning condition of the first nozzle for each reagent combination, wherein the reagent combination represents a combination of the reagent dispensed last time and the reagent to be dispensed this time. The control device is configured to acquire the reagent combination, and when a cleaning condition of the first nozzle is set for the acquired reagent combination, clean the first nozzle under the set cleaning condition.

[0126] According to the blood coagulation analysis device described in the first item, the first nozzle can be cleaned under the conditions set in advance for each reagent combination for the first nozzle used for dispensing the reagent, wherein the reagent combination represents the combination of the reagent dispensed last time and the reagent to be dispensed this time. Therefore, the first nozzle is cleaned under the conditions suitable for each reagent combination, and contamination between reagents in the first nozzle is suppressed.

[0127] (Second Item) In the blood coagulation analysis device described in the first Item, a cleaning condition in which the reagent dispensed last time is the same as the reagent to be dispensed this time (hereinafter referred to as "same-reagent condition") and a cleaning condition in which the reagent dispensed last time is different from the reagent to be dispensed this time (hereinafter referred to as "different-reagent condition") may be set for the first nozzle in the control device. The cleaning liquid indicated by the same-reagent condition may be pure water. The cleaning liquid indicated by the different-reagent condition may be a detergent.

[0128] Since the cleaning power of detergent is stronger than that of pure water, detergent cleaning is easier to remove stains from the first nozzle than pure water cleaning. On the other hand, compared with detergent cleaning, pure water cleaning can be performed more simply. In the case where the reagent dispensed last time is the same as the reagent to be dispensed this time, since it is not easy to produce inter-reagent contamination (i.e., contamination caused by the reagent dispensed last time), it is believed that even pure water cleaning can achieve sufficient cleanliness for the first nozzle. On the other hand, in the case where the reagent dispensed last time is different from the reagent to be dispensed this time, inter-reagent contamination is likely to occur. In such a case, by cleaning the first nozzle with detergent, it is possible to more reliably achieve sufficient cleanliness for the first nozzle. According to the blood coagulation analysis device described in the second item, it is possible to suppress contamination of the first nozzle while suppressing excessive cleaning.

[0129] (Item 3) In the blood coagulation analysis device described in Item 1 or Item 2, the control device may be configured to fill the first nozzle that has been dispensed with a cleaning liquid, and clean the first nozzle by causing the filled cleaning liquid to be ejected from the first nozzle. The cleaning conditions of the first nozzle may also include the type of cleaning liquid and the number of cleaning times, where the number of cleaning times indicates the number of times the filling and ejection of the cleaning liquid are repeated. The control device may also be configured to be able to set pure water and detergent as the type of cleaning liquid.

[0130] Detergent cleaning is easier to remove the attachments on the first nozzle than pure water cleaning. In addition, there is a tendency that the more times the first nozzle is cleaned, the higher the cleanliness of the first nozzle. On the other hand, if detergent cleaning is performed, it is troublesome to rinse off the detergent after the detergent cleaning is completed. In addition, if the number of times the first nozzle is cleaned is increased, the cleaning process becomes complicated or the cleaning time becomes longer. According to the blood coagulation analysis device described in the third item, by distinguishing between the use of pure water and detergent according to the reagent combination, or changing the number of cleaning times according to the reagent combination, the appropriateness of the cleaning degree can be achieved for each reagent combination. Therefore, it is possible to suppress contamination of the first nozzle while suppressing excessive cleaning.

[0131] (Item 4) In the blood coagulation analysis device described in Item 3, the following cleaning conditions may be set in the control device for at least one of the first to sixth combinations shown below. In the first combination, the reagent dispensed last time is AT3-1, the reagent to be dispensed this time is APTT reagent, and under the cleaning conditions of the first combination, the cleaning liquid is an alkaline detergent, and the number of cleaning times is one or more. In the second combination, the reagent dispensed last time is AT3-1, the reagent to be dispensed this time is CaCl2, and under the cleaning conditions of the second combination, the cleaning liquid is an alkaline detergent, and the number of cleaning times is one or more. In the third combination, the reagent dispensed last time is AT3-1, the reagent to be dispensed this time is PT reagent, and under the cleaning conditions of the third combination, the cleaning liquid is an alkaline detergent, and the number of cleaning times is one or more. In the fourth combination, the reagent dispensed last time is Fbg, the reagent to be dispensed this time is PT reagent, and under the cleaning conditions of the fourth combination, the cleaning liquid is an alkaline detergent, and the number of cleaning times is three or more. In the fifth combination, the reagent dispensed last time is Fbg, the reagent to be dispensed this time is APTT reagent, under the cleaning conditions of the fifth combination, the cleaning liquid is an alkaline detergent, and the number of cleanings is more than three times. In the sixth combination, the reagent dispensed last time is Fbg, the reagent to be dispensed this time is CaCl2, under the cleaning conditions of the sixth combination, the cleaning liquid is an alkaline detergent, and the number of cleanings is more than three times.

[0132] According to the blood coagulation analysis apparatus described in the fourth aspect, the first nozzle can be cleaned under conditions suitable for each reagent combination.

[0133] (Item 5) The blood coagulation analysis device described in any one of Items 1 to 4 may further include: a cleaning water tank for storing pure water; a cleaning water pump controlled by the control device to draw pure water from the cleaning water tank; a detergent port configured to supply detergent; and a cleaning port for recovering the cleaning liquid. The first dispensing device may further include a first injection pump located between the cleaning water pump and the first nozzle. The cleaning water pump may also be configured to supply the pure water stored in the cleaning water tank to the first injection pump and the first nozzle. The first injection pump may also be configured to be controlled by the control device to adjust the suction pressure and discharge pressure of the first nozzle. The control device may also be configured to: when the first nozzle is cleaned with pure water, control the first injection pump to supply and fill the pure water supplied from the cleaning water tank to the first injection pump to the first nozzle, and cause the first nozzle to discharge the filled pure water to the cleaning port; when the first nozzle is cleaned with detergent, control the first injection pump to cause the first nozzle to suck the detergent supplied from the detergent port, thereby filling the first nozzle with detergent, and cause the first nozzle to discharge the filled detergent to the cleaning port.

[0134] In the blood coagulation analysis device described in the fifth item, pure water is supplied to the first nozzle from the cleaning water tank via the first injection pump (i.e., a pump for adjusting the pressure of the first nozzle) by a cleaning water pump. When performing pure water cleaning, the first nozzle does not contact the pure water in the cleaning water tank, so it is easy to maintain the pure water in the cleaning water tank at a sufficient cleanliness. On the other hand, the detergent is provided by the detergent port and sucked by the first nozzle. Therefore, the detergent can be selectively attached to the vicinity of the opening of the first nozzle that is easily contaminated (i.e., the opening for suction and ejection). By performing detergent cleaning in this way, it is easy to remove the detergent from the first nozzle after the detergent cleaning is completed. In addition, in the blood coagulation analysis device described in the fifth item, a cleaning port for recovering the used cleaning liquid (e.g., pure water and detergent) is prepared separately from the cleaning water tank and the detergent port for providing the cleaning liquid. By having such a cleaning port, it is possible to suppress contamination caused by the used cleaning liquid (e.g., contamination of the cleaning water tank and the detergent port, respectively). As described above, according to the blood coagulation analysis apparatus described in the fifth aspect, the first nozzle can be easily cleaned while suppressing contamination of the first nozzle.

[0135] (Item 6) In the blood coagulation analysis device described in any one of Items 1 to 5, the control device can also be configured to: obtain a reagent combination, and when no cleaning conditions for the first nozzle are set for the obtained reagent combination, clean the first nozzle under specified standard conditions.

[0136] According to the blood coagulation analysis apparatus described in item 6, when the cleaning condition of the first nozzle is not set for the reagent set, even if the user does not set the cleaning condition, the first nozzle can be cleaned under the predetermined standard condition.

[0137] (Item 7) In the blood coagulation analysis device described in any one of Items 1 to 5, the control device may be configured to: obtain a reagent combination, and when a cleaning condition of the first nozzle is not set for the obtained reagent combination, request the user to set the cleaning condition.

[0138] According to the blood coagulation analysis apparatus described in item 7, when the cleaning condition of the first nozzle is not set for the reagent set, the control device requests the user to set the cleaning condition. The user can set the cleaning condition in response to the request from the control device.

[0139] (Item 8) The blood coagulation analysis device described in any one of Items 1 to 7 may further include a specimen port and a second dispensing device. The specimen port may also be configured to be able to provide a plurality of specimens. The second dispensing device may also include a second nozzle and a second driving device, the second driving device being configured to move the second nozzle to change the position of the second nozzle. The second dispensing device may also be configured to aspirate a predetermined specimen among a plurality of specimens at the specimen port and dispense the aspirated specimen from the second nozzle into the reaction container. The control device may also be configured to control the second dispensing device to dispense the specimen using the second nozzle, and to clean the second nozzle each time the specimen is dispensed. The control device may also be configured to be able to set a cleaning condition for the second nozzle for each specimen combination, the specimen combination indicating a combination of a specimen dispensed last time and a specimen to be dispensed this time. The control device may also be configured to obtain a specimen combination, and when a cleaning condition for the second nozzle is set for the acquired specimen combination, clean the second nozzle with the set cleaning condition.

[0140] According to the blood coagulation analysis device described in the eighth item, the second nozzle can be cleaned under the conditions pre-set for each sample combination for the second nozzle used for dispensing the sample, and the sample combination represents the combination of the sample dispensed last time and the sample to be dispensed this time. Therefore, the second nozzle can be cleaned under the conditions suitable for each sample combination. Thus, contamination between samples in the second nozzle is suppressed.

[0141] (Item 9) The blood coagulation analysis device described in Item 8 may also include a supply device, a conveying device, a measuring device, and a discard port. The supply device may also be configured to have a storage portion capable of accommodating a plurality of reaction containers, and the reaction containers are supplied from the storage portion. The conveying device may also be configured to be controlled by the control device to convey the reaction container. The measuring device may also be configured to be controlled by the control device to perform a prescribed measurement on the contents of the reaction container. The discard port may also be configured to be used to recover the reaction container. The control device may also be configured to dispense the specimen and the reagent into the reaction container supplied from the storage portion by the first dispensing device and the second dispensing device, and perform a prescribed measurement by the measuring device, and discard the reaction container subjected to the prescribed measurement to the discard port by the conveying device.

[0142] When the specimen and the reagent are dispensed into the reaction container, the specimen reacts with the reagent in the reaction container to generate a reaction product. It is difficult to completely remove foreign matter attached to such a reaction container by automatic cleaning. In this regard, in the blood coagulation analysis device described in the ninth item, a disposable reaction container is used. After the above-mentioned dispensing and measurement are performed on a new reaction container (i.e., an unused reaction container) supplied from the receiving portion of the supply device, the measured reaction container is discarded to the discard port. By using a new reaction container with high cleanliness for the above-mentioned dispensing and measurement, the analysis accuracy can be improved.

[0143] (Item 10) A method for cleaning a dispensing nozzle according to one embodiment is used to clean a dispensing nozzle used for dispensing a reagent in a blood coagulation analysis device that performs analysis by reacting a specimen and a reagent in a reaction container, and the method for cleaning a dispensing nozzle includes the first to third steps shown below. In the first step, a control device of the blood coagulation analysis device obtains a reagent combination representing a combination of a reagent dispensed last time and a reagent to be dispensed this time for the dispensing nozzle. In the second step, the control device determines whether a cleaning condition for the dispensing nozzle is pre-set for the reagent combination obtained in the first step. In the third step, when it is determined in the second step that a cleaning condition for the dispensing nozzle is pre-set for the reagent combination, the control device cleans the dispensing nozzle using the cleaning condition pre-set for the reagent combination.

[0144] According to the method for cleaning a dispensing nozzle as described in the tenth item, the dispensing nozzle can be cleaned under the conditions pre-set for each reagent combination for the dispensing nozzle used for dispensing the reagent, wherein the reagent combination represents the combination of the reagent dispensed last time and the reagent to be dispensed this time. Therefore, the dispensing nozzle is cleaned under the conditions suitable for each reagent combination, and contamination between reagents in the dispensing nozzle is suppressed.

[0145] Although the embodiments of the present invention have been described, the embodiments disclosed this time should be considered to be illustrative in all aspects and not restrictive. The scope of the present invention is indicated by the claims, and all modifications within the meaning and scope equivalent to the claims are included.

Claims

1. A blood coagulation analysis device for performing analysis by reacting a sample and a reagent in a reaction container, the blood coagulation analysis device comprising: a reagent port configured to provide a plurality of reagents; The first dispensing device is configured to include a first nozzle and a first driving device, and sucks a predetermined reagent from among the plurality of reagents at the reagent port through the first nozzle, and dispenses the sucked reagent from the first nozzle into the reaction container, wherein: The first driving device is configured to move the first nozzle to change the position of the first nozzle; and a control device, which controls the first dispensing device, The control device is configured to control the first dispensing device to dispense the reagent using the first nozzle, and clean the first nozzle each time the reagent is dispensed. The control device is configured to set a cleaning condition for the first nozzle for each reagent combination, wherein the reagent combination indicates a combination of a reagent dispensed last time and a reagent to be dispensed this time. The control device is configured to: acquire the reagent combination, and when the cleaning condition of the first nozzle is set for the acquired reagent combination, clean the first nozzle according to the set cleaning condition; Wherein, in the control device, the cleaning condition is set for at least one of the first combination, the second combination, the third combination, the fourth combination, the fifth combination and the sixth combination, Among them, in the first combination, the reagent dispensed last time is AT3-1, and the reagent to be dispensed this time is APTT reagent, In the second combination, the reagent dispensed last time is AT3-1, and the reagent to be dispensed this time is CaCl2. In the third combination, the reagent dispensed last time is AT3-1, and the reagent to be dispensed this time is PT reagent. In the fourth combination, the reagent dispensed last time is Fbg, and the reagent to be dispensed this time is PT reagent. In the fifth combination, the reagent dispensed last time is Fbg, and the reagent to be dispensed this time is APTT reagent. In the sixth combination, the reagent dispensed last time is Fbg, and the reagent to be dispensed this time is CaCl2. Under the first combination of cleaning conditions, the cleaning liquid is an alkaline detergent, the cleaning times are more than one, Under the cleaning conditions of the second combination, the cleaning liquid is an alkaline detergent, the cleaning times are more than one, Under the cleaning conditions of the third combination, the cleaning liquid is an alkaline detergent, the cleaning times are more than one, Under the cleaning conditions of the fourth combination, the cleaning liquid is an alkaline detergent, the cleaning times are three or more, Under the cleaning conditions of the fifth combination, the cleaning liquid is an alkaline detergent, the cleaning times are three or more, Under the cleaning conditions of the sixth combination, the cleaning liquid is an alkaline detergent, and the number of cleaning times is more than three times.

2. The blood coagulation analysis device according to claim 1, characterized in that: In the control device, a same-reagent condition and a different-reagent condition are set for the first nozzle, wherein the same-reagent condition is a cleaning condition when the reagent dispensed last time is the same as the reagent to be dispensed this time, and the different-reagent condition is a cleaning condition when the reagent dispensed last time is different from the reagent to be dispensed this time, The cleaning solution represented by the same reagent conditions is pure water, The heterologous reagent conditions indicate that the cleaning solution is a detergent.

3. The blood coagulation analysis device according to claim 1, characterized in that: The control device is configured to fill the first nozzle that has been dispensed with the cleaning liquid, and clean the first nozzle by ejecting the filled cleaning liquid from the first nozzle. The cleaning condition of the first nozzle includes the type of the cleaning liquid and the number of cleaning times, wherein the number of cleaning times indicates the number of times the filling and ejection of the cleaning liquid are repeated. The control device is configured to be able to set pure water and detergent as the type of the cleaning liquid.

4. The blood coagulation analysis device according to any one of claims 1 to 3, characterized in that: Also available: A cleaning water tank, which is used to contain pure water; a cleaning water pump, which is controlled by the control device to draw the pure water from the cleaning water tank; a detergent port configured to provide detergent; as well as Cleaning port, which is used to recover cleaning fluid, The first dispensing device also has a first injection pump located between the cleaning water pump and the first nozzle. The cleaning water pump is configured to supply the pure water contained in the cleaning water tank to the first injection pump and the first nozzle. The first injection pump is configured to be controllable by the control device to adjust the suction pressure and discharge pressure of the first nozzle. The control device is configured as follows: when the first nozzle is cleaned with pure water, the first injection pump is controlled to supply the pure water supplied from the cleaning water tank to the first injection pump and fill it into the first nozzle, and the first nozzle is caused to spray the filled pure water toward the cleaning port; when the first nozzle is cleaned with detergent, the first injection pump is controlled to cause the first nozzle to suck the detergent provided by the detergent port, thereby filling the first nozzle with the detergent, and the first nozzle is caused to spray the filled detergent toward the cleaning port.

5. The blood coagulation analysis device according to any one of claims 1 to 3, characterized in that: The control device is configured to acquire the reagent combination, and, when the cleaning condition of the first nozzle is not set for the acquired reagent combination, clean the first nozzle under a predetermined standard condition.

6. The blood coagulation analysis device according to any one of claims 1 to 3, characterized in that: The control device is configured to acquire the reagent combination and, when the cleaning condition of the first nozzle is not set for the acquired reagent combination, request a user to set the cleaning condition.

7. The blood coagulation analysis device according to any one of claims 1 to 3, characterized in that: Also available: a sample port configured to provide a plurality of samples; and The second dispensing device is configured to include a second nozzle and a second driving device, and sucks a specified specimen from the plurality of specimens at the specimen port through the second nozzle, and dispenses the sucked specimen from the second nozzle into the reaction container, wherein the second driving device is configured to move the second nozzle to change the position of the second nozzle, The control device is configured to: control the second dispensing device to dispense the sample using the second nozzle, and clean the second nozzle each time the sample is dispensed. The control device is configured to set a cleaning condition for the second nozzle for each sample combination, wherein the sample combination indicates a combination of a sample dispensed last time and a sample to be dispensed this time. The control device is configured to acquire the sample combination, and when the cleaning condition of the second nozzle is set for the acquired sample combination, clean the second nozzle under the set cleaning condition.

8. The blood coagulation analysis device according to claim 7, characterized in that: Also available: a supply device having a receiving portion capable of receiving a plurality of the reaction containers, and supplying the reaction containers from the receiving portion; a conveying device configured to be controlled by the control device to convey the reaction container; a measuring device configured to be controlled by the control device to perform a predetermined measurement on the content of the reaction container; as well as a waste port for recovering the reaction vessel, The control device is configured to dispense the specimen and the reagent into the reaction container supplied from the storage portion through the first dispensing device and the second dispensing device, perform the specified measurement through the measuring device, and discard the reaction container subjected to the specified measurement to the disposal port through the transport device.

9. A method for cleaning a dispensing nozzle, for cleaning a dispensing nozzle for dispensing a reagent in a blood coagulation analysis device that performs analysis by reacting a specimen and a reagent in a reaction container, the method comprising: In a first step, the control device of the blood coagulation analyzer acquires a reagent combination indicating a combination of a reagent dispensed last time and a reagent to be dispensed this time for the dispensing nozzle; In a second step, the control device determines whether a cleaning condition of the dispensing nozzle is pre-set for the reagent combination acquired in the first step; as well as In a third step, when it is determined in the second step that a cleaning condition for the dispensing nozzle is pre-set for the reagent combination, the control device cleans the dispensing nozzle using the cleaning condition pre-set for the reagent combination. The cleaning condition is set for at least one of the first combination, the second combination, the third combination, the fourth combination, the fifth combination and the sixth combination, Among them, in the first combination, the reagent dispensed last time is AT3-1, and the reagent to be dispensed this time is APTT reagent, In the second combination, the reagent dispensed last time is AT3-1, and the reagent to be dispensed this time is CaCl2. In the third combination, the reagent dispensed last time is AT3-1, and the reagent to be dispensed this time is PT reagent. In the fourth combination, the reagent dispensed last time is Fbg, and the reagent to be dispensed this time is PT reagent. In the fifth combination, the reagent dispensed last time is Fbg, and the reagent to be dispensed this time is APTT reagent. In the sixth combination, the reagent dispensed last time is Fbg, and the reagent to be dispensed this time is CaCl2. Under the first combination of cleaning conditions, the cleaning liquid is an alkaline detergent, the cleaning times are more than one, Under the cleaning conditions of the second combination, the cleaning liquid is an alkaline detergent, the cleaning times are more than one, Under the cleaning conditions of the third combination, the cleaning liquid is an alkaline detergent, the cleaning times are more than one, Under the cleaning conditions of the fourth combination, the cleaning liquid is an alkaline detergent, the cleaning times are three or more, Under the cleaning conditions of the fifth combination, the cleaning liquid is an alkaline detergent, the cleaning times are three or more, Under the cleaning conditions of the sixth combination, the cleaning liquid is an alkaline detergent, and the number of cleaning times is more than three times.

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