Analysis device

Abstract

The present invention relates to suppressing the enlargement of an analysis device capable of performing multiple analyses. The analysis device includes: a first measurement unit, the first measurement unit holds a cuvette dispensed with a biological sample and performs a first measurement on the contents of the cuvette; a second measurement unit, the second measurement unit holds the cuvette and performs a second measurement different from the first measurement on the contents of the cuvette; and a transport unit, the transport unit holds the cuvette and transports the cuvette to a loading and unloading position of the first measurement unit or a loading and unloading position of the second measurement unit, the transport unit moves along a guide rail, and the loading and unloading position of the first measurement unit and the loading and unloading position of the second measurement unit are set on a line substantially along the guide rail.

Description

Technical Field

[0001] The present invention relates to an analytical device. Background Art

[0002] In the past, a device capable of performing a variety of analyses using different measurement methods, such as biochemical analysis and immunological analysis, has been proposed (e.g., Patent Document 1). The device includes: (1) a sample supply unit having a sample rack capable of loading a plurality of biological samples; (2) a first measurement unit capable of holding a plurality of reaction cuvettes independently of each other in a manner that allows the reaction cuvettes to be independently loaded and unloaded, and having a first optical system measurement means; (3) a sample transport means capable of transporting the biological sample from the sample supply unit to the reaction cuvette on the first measurement unit; (4) a second measurement unit capable of holding a plurality of reaction cuvettes independently of each other in a manner that allows the reaction cuvettes to be independently loaded and unloaded, and having a second optical system measurement means; (5) a colorimetric unit capable of holding a plurality of reaction cuvettes independently of each other in a manner that allows the reaction cuvettes to be independently loaded and unloaded, and having a second optical system measurement means; (a) a reaction cuvette transfer means capable of transferring the reaction cuvette on the first measuring unit to the second measuring unit; (6) a reagent supply unit having reagents used in the measurements of the first measuring unit and the measurements of the second measuring unit; and (7) a reagent delivery means capable of delivering the reaction reagents from the reagent supply unit to the reaction cuvettes on the first measuring unit and / or the second measuring unit independently of each other, wherein the reaction cuvette on the second measuring unit is transferred from the first measuring unit to the second measuring unit by the cuvette delivery means after the biological sample is dispensed on the first measuring unit, and different measurements can be performed in the first measuring unit and the second measuring unit.

[0003] Prior art literature

[0004] Patent Literature

[0005] Patent Document 1: International Publication No. 2006 / 107016 Summary of the invention

[0006] Technical problem to be solved by the invention

[0007] When a device can perform multiple analyses, the device will usually be large-scale. In addition, in the random measurements of various measurement mechanisms in the past, it is difficult to perform multiple measurements while maintaining the measurement processing capacity (the number of specimen samples performed per hour), and in order to achieve this goal, the measurement processing capacity will be reduced. Furthermore, the increase in manufacturing costs caused by large-scale is also a technical problem. Therefore, the purpose of the present technology is to suppress the large-scale device of an analysis device that can perform multiple analyses.

[0008] In addition, the coagulation time of blood varies from sample to sample. In a general automatic analyzer, a designated measurement time of the sample is set and the measurement is performed based on the required time obtained by multiple coagulation time measurements. When the measurement cannot be completed within the designated measurement time due to an abnormality such as the blood coagulation reaction not being completed within the designated measurement time, a retest mode is set and the measurement is repeated again starting from the sample collection. However, in this method, there are problems such as a large amount of sample to be prepared and low overall measurement processing efficiency due to the fact that two measurements are actually performed. On the other hand, if the designated measurement time is extended to avoid retesting, there is a disadvantage of low overall measurement processing efficiency. Therefore, another object of the present invention is to improve the measurement processing performance of a device for measuring the extent of progress of a designated reaction.

[0009] In addition, in clinical examinations, tests for pathological blood coagulation ability caused by the activity of blood coagulation factors are usually performed. Physiological hemostasis includes an exogenous coagulation system and an intrinsic coagulation system. The exogenous coagulation system is initiated by the binding of tissue factor (TF) exposed to the site of injury and active factor VII, while the intrinsic coagulation system is initiated independently of TF. Coagulation tests such as prothrombin time (PT) determination and activated partial thromboplastin time (APTT) determination reproduce the above reaction in a test tube, add reagents to the test plasma, and measure the time (coagulation time) for thrombin generated by the activation of each coagulation factor to convert fibrinogen into fibrin (fibrin formation). PT is the time until coagulation is observed after adding calcium ions at a concentration that can show blood coagulation activity to lipidated thromboplastin to the test plasma, and it is a comprehensive indicator of exogenous (factors VII, X, V, prothrombin, fibrinogen) coagulation activity. APTT is the time taken to observe coagulation after adding liposomes and activators represented by colloidal silica and oleic acid, as well as calcium ions at a concentration that can express blood coagulation activity to the test plasma. It is a comprehensive indicator of endogenous (factors XII, XI, IX, VIII, X, V, II, and fibrinogen) coagulation activity.

[0010] When the extension of clotting time is observed, in order to study the extension cause, a cross-mixing test is implemented. That is, a specimen of patient plasma and normal plasma is mixed with a specified multiple ratio modulation, and the clotting time (APTT or PT) is measured. In the cross-mixing test, for the mixed specimen, the result of the clotting time measured immediately after mixing is compared with the result of the clotting time measured after heating at a specified temperature for 2 hours. In addition, through the cross-mixing test, it can be judged whether the cause of the extension of the clotting time is the defect of the coagulation factor or the inhibitor of the coagulation factor. However, the cross-mixing test is labor-consuming and time-consuming, and is difficult to automate. Therefore, another object of the present invention is to provide a technology that supports the implementation of the cross-mixing test.

[0011] Technical means to solve technical problems

[0012] The analysis device according to the present invention includes: a first measuring unit, which holds a cuvette with a biological sample dispensed therein and performs a first measurement on the contents of the cuvette; a second measuring unit, which holds the cuvette and performs a second measurement different from the first measurement on the contents of the cuvette; and a transport unit, which holds the cuvette and transports the cuvette to a loading and unloading position of the first measuring unit or a loading and unloading position of the second measuring unit, the transport unit moves coaxially along a coaxial guide rail, and the loading and unloading position of the first measuring unit and the loading and unloading position of the second measuring unit are arranged on a coaxial line substantially parallel to the guide rail.

[0013] In this way, by moving the transport unit along a simple track, the transport unit can be miniaturized, and the overall device can be prevented from being enlarged, which can also contribute to a reduction in manufacturing costs.

[0014] In addition, a cuvette supply unit for supplying the cuvette to the supply port may be further included, and the supply port of the cuvette supply unit, the loading and unloading position of the first measuring unit, and the loading and unloading position of the second measuring unit may be coaxially arranged. In addition, a waste port for discarding the cuvette may be further included, and the waste port, the loading and unloading position of the first measuring unit, and the loading and unloading position of the second measuring unit may be coaxially arranged.

[0015] In addition, it may further include: a reagent table, the reagent table holds a plurality of reagent containers for holding reagents; and a reagent nozzle unit, the reagent nozzle unit collects reagents from the reagent container at a designated collection position, and dispenses the collected reagents into a cuvette held in the first measurement unit or the second measurement unit at a designated dispensing position, the reagent nozzle unit can move coaxially along the guide rail, and the collection position and the dispensing position can be set on a coaxial line substantially parallel to the guide rail. In this way, the conveying unit and the reagent nozzle unit can share the guide rail, making it possible to efficiently use the designated measurement time and space, and to achieve a higher measurement processing capacity and suppress the enlargement of the overall device.

[0016] In addition, a reagent nozzle cleaning tank may be further included, wherein the reagent nozzle cleaning tank cleans the reagent nozzle disposed in the reagent nozzle unit, and the reagent nozzle cleaning tank, the above-mentioned collection position, and the dispensing position may be disposed on a straight line.

[0017] The analysis device according to the present invention includes: a measuring unit, which holds a cuvette into which a biological sample is dispensed and outputs data indicating the extent of a specified reaction occurring in the contents of the cuvette; and a processor, which, after a predetermined measuring time has elapsed, when it is determined based on the data output by the measuring unit that the specified reaction has not ended, extends the measuring time so that the measuring process continues.

[0018] In this way, it is not necessary to extend the measurement time of a specimen in advance for safety reasons, and the reduction in measurement processing efficiency can be suppressed. In addition, if the measurement is temporarily terminated within the reference measurement time and the specified reaction is not completed, the sample is re-measured, and the efficiency is very poor due to the time spent on the re-measurement and the waste of the specimen that has not completed the reaction. By adopting the process according to the present invention, the waste of time and specimens can be eliminated, thereby improving the measurement processing efficiency.

[0019] The designated reaction may be blood coagulation. Specifically, it can be applied to such analysis.

[0020] The mixing test support device according to the present invention includes: a dispensing mechanism, which collects a biological sample from a container containing the biological sample and dispenses it into a sample cup; a measuring unit, which holds a cuvette containing the sample dispensed from the sample cup and measures the coagulation time of the content of the cuvette; a processor, which enables the dispensing mechanism to prepare a mixed sample of a normal sample and a patient sample in the sample cup, wherein the mixed sample is obtained by mixing the normal sample and the patient sample contained in different containers in an amount of specimens that can be measured multiple times and in a specified ratio, and the processor enables the measuring unit to perform an instant coagulation time measurement on the prepared mixed sample.

[0021] When a specified amount of mixed sample for coagulation time measurement is prepared in the dispensing mechanism and a mixed test is performed, the user does not need to spend time preparing samples for measuring immediate reaction and delayed reaction. In addition, since the samples for immediate reaction and delayed reaction can be prepared at the same time, there is no error in the preparation of the samples. In addition, since the measurement of the immediate reaction can be started quickly, it is not necessary to spend time to separately arrange the measurement of the prepared samples.

[0022] In addition, an input / output device for inputting and outputting information according to the user's operation may be further included. The processor may cause the measuring unit to measure the coagulation time of the mixed sample after being heated for a specified time, and receive input of the correspondence between the mixed sample for which the immediate coagulation time is measured and the mixed sample for which the coagulation time is measured after being heated for a specified time via the input / output device, and the processor obtains information related to the coagulation time measured for the corresponding mixed sample from the measuring unit, and causes the input / output device to output the information. For example, heating is performed at 37 degrees for 2 hours. Since the APTT of both the immediate reaction and the delayed reaction can be measured in this device, the results of the immediate reaction and the delayed reaction can be output together in a manner that is easy for the user to compare.

[0023] In addition, without departing from the scope of the subject matter and technical concept of the present invention, the contents recorded in the technical means for solving the technical problem can be combined as much as possible. In addition, the contents of the technical means for solving the technical problem can be provided as a system including a device such as a computer or a plurality of devices, a method executed by a computer, or a program executed by a computer. The program can also be executed on a network. In addition, a recording medium for storing the program can also be provided.

[0024] Effects of the Invention

[0025] The device size and manufacturing cost of an analysis device capable of performing a variety of analyses can be suppressed. In addition, the measurement processing performance can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] [ Figure 1 ] is a diagram showing an embodiment of a composite analysis device.

[0027] [ Figure 2 ] is a plan view showing an embodiment of the internal structure of the measurement unit storage section of the complex analysis device.

[0028] [ Figure 3A ] is a diagram showing an embodiment of a sample rack.

[0029] [ Figure 3B ] is a diagram showing an embodiment of a sample rack.

[0030] [ Figure 4 ] is a diagram showing an embodiment of a cuvette supply unit.

[0031] [ Figure 5 ] is a diagram showing an embodiment of a sample nozzle unit.

[0032] [ Figure 6 ] is a diagram showing an embodiment of a portion of a reagent station.

[0033] [ Figure 7 ] is a diagram showing an embodiment of a reagent cover opening and closing unit.

[0034] [ Figure 8 ] is a diagram showing an embodiment of a reagent nozzle unit.

[0035] [ Fig. 9 ] is a diagram showing an embodiment of a solidification table.

[0036] [ Fig.10 ] is a diagram showing an embodiment of an LPIA station.

[0037] [ Fig.11 ] is a diagram showing an embodiment of a cuvette chuck unit.

[0038] [ Fig. 12A ] is a plan view showing an embodiment of a track.

[0039] [ Fig. 12B ] is a front view showing an embodiment of a track.

[0040] [ Fig.13 ] is a functional block diagram showing one embodiment of a computer.

[0041] [ Fig.14 ] is a processing flow chart showing an embodiment of measurement time extension processing.

[0042] [ Fig.15 ] is a functional block diagram showing one embodiment of a computer.

[0043] [ Fig.16 ] is a process flow diagram showing an embodiment of hybrid trial support processing.

[0044] [ Fig.17 ] is a diagram showing an embodiment of the output measurement results.

[0045] [ Fig.18 ] is a schematic diagram showing an embodiment of a complex analysis device having three measurement units. DETAILED DESCRIPTION

[0046] Hereinafter, a composite analysis device according to an embodiment of the present invention will be described with reference to the drawings.

[0047] <Device Structure>

[0048] Figure 11 is a diagram showing an embodiment of the appearance of a composite analysis device 1000. The composite analysis device 1000 is an analysis device that performs a variety of analyses with different measurement accuracy, such as biochemical analysis and immunological analysis. The composite analysis device 1000 can perform, for example, LPIA (Latex Photometric Immunoassay), blood coagulation time measurement, etc. In addition, the composite analysis device 1000 includes a measurement unit storage unit 1, a storage unit 2 such as a box, a monitor 3, and a status output unit 4. The measurement unit storage unit 1 stores a plurality of measurement units according to an embodiment of the present invention, etc. The storage unit 2 such as a box contains troughs for storing pure water, washing water and drainage, a waste box for collecting discarded cuvettes, a computer for controlling the processing performed by the measurement unit storage unit 1, etc. The monitor 3 is connected to the computer to output the progress and results of the measurement, etc. In addition, the monitor 3 can also be an input-output device such as a touch panel that can be input and operated by the user. The status output unit 4 is connected to a computer or the like, and when an abnormality occurs in the process executed by the measurement unit storage unit 1, the status output unit 4 flashes or lights a warning lamp to notify the user.

[0049] Figure 21 is a plan view showing an embodiment of the internal structure of the measuring unit storage unit 1 of the composite analysis device 1000. The measuring unit storage unit 1 includes a conveying space 101 of a sample rack, a cuvette supply unit 102, a sample nozzle unit 103, a reagent table 104, a reagent cover opening and closing unit 105, a reagent nozzle unit 106, a coagulation table 107, an LPIA table 108, a cuvette chuck unit 109, a track 110, and a cuvette waste port 111. The sample rack 1011 is placed on the conveying space 101 and is conveyed on the table by a designated mechanism. The sample rack 1011 holds a plurality of blood collection tubes for accommodating biological samples such as blood specimens. The cuvette supply unit 102 supplies cuvettes of a designated shape for use in the composite analysis device 1000. In addition, the cuvettes are supplied one by one in sequence from the cuvette supply port 1021. The sample nozzle unit 103 is provided with a nozzle connected to a pump, and moves within a specified movable range based on the control of a computer, collects samples from a blood collection tube and ejects them to a cuvette of an LPIA station 108. The reagent station 104 is a disc-shaped holding portion, which holds a plurality of reagent bottles for containing reagents and rotates based on the control of a computer. The held reagent bottles are collected at a specified collection position 1041 by the reagent nozzle unit 106. The reagent cover opening and closing unit 105 is a unit for opening and closing the cover of the reagent bottle, and moves within a specified movable range based on the control of a computer. The reagent nozzle unit 106 is provided with a nozzle connected to a pump, and moves within a specified working range based on the control of a computer, collects reagents from the reagent bottle and ejects them to a cuvette. The coagulation station 107 is a holding portion provided with a plurality of holes for arranging and holding a plurality of cuvettes, so as to measure the coagulation degree of the contents of the cuvettes. In addition, the light source and the light receiving portion are configured to sandwich the held cuvettes therebetween, so as to measure the coagulation degree according to the absorbance or transmittance of the contents. LPIA platform 108 is a disc-shaped holding portion, which rotates based on the control of a computer while holding a plurality of cuvettes in a circular arrangement in a plan view, so as to measure the amount of antigen in a specimen by LPIA. The held cuvette is loaded and unloaded by a cuvette chuck unit 109 at a specified loading and unloading position 1081, and is dispensed with reagent at a specified dispensing position 1082. The cuvette chuck unit 109 moves within a specified movable range based on the control of a computer, and holds and moves the cuvette. Track 110 is a linear track. Reagent nozzle unit 106 and cuvette chuck unit 109 are connected to track 110 respectively, and move approximately parallel to track 110 along the extension direction of track 110. Cuvette waste port 111 is an opening portion communicated with a discard box contained in a storage unit 2 such as a box, and cuvettes etc. can be discarded in the cuvette waste port 111.

[0050] Figure 3A and Figure 3B1 is a diagram showing an embodiment of a sample rack. The sample rack 1011 has a plurality of brackets to hold blood collection tubes 1012 for accommodating samples. In addition, the sample rack 1011 is transported based on the control of a computer, and the desired blood collection tube 1012 can be arranged at a designated collection position. The collection position exists on a moving track of the sample nozzle unit 103 that is arc-shaped in a plan view, and the sample is dispensed by the sample nozzle unit 103 into a cuvette held in a holding hole of the LPIA station 108. In addition, the composite analysis device 1000 can also be provided with a reading device for optically reading identification information such as a barcode or a two-dimensional code attached to a label of the blood collection tube 1012, so that the desired blood collection tube can be determined. In addition, a sample cup can also be arranged on the blood collection tube, and a diluted sample and a mixed sample can be prepared in the sample cup.

[0051] Figure 4 1 is a diagram showing an embodiment of a cuvette supply unit 102. The cuvettes put into the hopper 1022 are supplied one by one from the cuvette supply port 1021 in a designated direction by the cuvette supply unit 102 through a designated mechanism. The cuvette supply port 1021 is the end of the inclined outlet of the cuvette supply unit 102.

[0052] Figure 5 1 is a diagram showing an embodiment of a sample nozzle unit. In the sample nozzle unit 103, the nozzle 1034 moves along a circular arc track in a plan view with a designated rotation axis 1033 as the center. Then, the sample nozzle unit 103 dispenses the sample from the blood collection tube 1012 of the sample rack 1011 moved to the collection position into the cuvette of the LPIA stage 108 moved to the dispensing position 1031. The sample nozzle unit 103 is also referred to as a "dispensing mechanism" according to the present invention.

[0053] Figure 6It is a plan view of an embodiment of a part of the reagent table. Reagents are, for example, latex and coagulation time reagents, but are not limited thereto. According to the type of the determination principle, the composition of the reagent table can be appropriately changed. The reagent table 104 is a disc-shaped table rotating around a specified rotation axis, in which a plurality of setting parts 1042 for holding a reagent bottle are arranged in a ring shape. And, in the present embodiment, the setting part 1042 is arranged as a double ring, but the number of the setting part 1042 and the number of the rings are not particularly limited. In addition, the reagent table 104 is provided with a rod-shaped convex part 1043 protruding toward the vertical top around the setting part 1042. In the present embodiment, each setting part 1042 is provided with a convex part 1043 on the rotation axis side. In addition, the reagent bottle according to the present embodiment is basically cylindrical, and is provided with a joint part capable of inserting the above-mentioned convex part 1043 on its side. The joint part is a through hole penetrating in the vertical direction or a recessed part opened vertically below, and the convex part 1043 is inserted into the joint part so as to fix the reagent bottle. In addition, the reagent table is controlled by a computer to rotate clockwise or counterclockwise and stop at a specified position. For example, each setting part 1042 can stop at the following positions: the reagent collection position at the intersection of the nozzle movement track of the reagent nozzle unit 106 in the plan view, the cover opening and closing position under the reagent cover opening and closing unit 105, and the loading and unloading position of the reagent bottle for the user. In addition, the composite analysis device 1000 can also be equipped with a reading device for optically reading the identification information such as the bar code or the two-dimensional code attached to the label of the reagent bottle, so that the desired reagent bottle can be determined. For example, in the plan view, the reading device can be arranged in the direction from the outside of the reagent table 104 toward the rotation axis. In addition, for a plurality of setting parts 1042 arranged in a double ring, for example, by making the setting parts 1042 on the inner circumference side and the setting parts 1042 on the outer circumference side staggered along the circumference (chidori configuration), the reagent bottles do not overlap when viewed from the reading device, so that the labels of all reagent bottles can be read by rotating the reagent table 104. In addition, the setting part 1042 can also be set to more than 3 concentric circles. When the retaining hole is set to multiple concentric circles, the reagent table can be a disk that rotates as a whole, or it can be formed by multiple annular disks that can rotate independently of each other by multiple concentric circles. When multiple annular disks are structures that rotate independently, based on the control of the computer, each ring rotates clockwise or counterclockwise independently, and stops independently of each other. Although the type and quantity of the reagent used according to the determination method are different, by rotating the reagent table 104, the setting part 1042 of the desired reagent bottle can be moved to the collection position 1041, so that it can be used according to the determination. In addition, if the composite analysis device 1000 reads the identification information pasted on the reagent bottle and automatically stores the configuration of the reagent bottle on the reagent table 104, the user only needs to set the reagent bottle required for the determination and can complete the preparation, and there is no need to care about the setting position, thereby improving convenience.Furthermore, since the reagent table 104 has the plurality of installation sections 1042 , the number of measurement items can be increased without replacing reagent bottles, thereby improving convenience.

[0054] Figure 7 It is a figure showing an embodiment of a reagent cover opening and closing unit. The reagent cover opening and closing unit 105 opens and closes the cover of the reagent bottle by its front end 1051. The cover of the reagent bottle according to the present embodiment is hinged, and is opened and closed by applying a moment on the cover along the specified opening and closing direction. A convex portion protruding in a direction substantially perpendicular to the cover is provided on the cover of the reagent bottle, so that the front end 1051 applies a force. If the force in the specified opening direction is applied to the convex portion, the moment acts on the hinge, and the moment causes the cover to rotate along the opening direction with the hinge as a fulcrum. The front end 1051 of the reagent cover opening and closing unit 105 moves along the radial direction of the reagent table 104 in the plan view, and contacts with the convex portion protruding from the cover while being displaced on the moving track of the reagent bottle by the rotation of the reagent table 104, and then opens the cover. In addition, the front end 1051 of the reagent cover opening and closing unit 105 is also displaced in the vertical direction by specifying a driving mechanism. The front end portion 1051 applies a force in the cap closing direction opposite to the cap opening direction to the cap, while pressing the cap vertically downward, so that the reagent bottle is capped.

[0055] Figure 8 1 is a diagram showing an embodiment of a reagent nozzle unit. The reagent nozzle unit 106 according to the present embodiment has two nozzles 1062 for collecting and ejecting reagent. The two nozzles 1062 can move up and down in the vertical direction independently of each other, collect and eject reagent. In addition, the reagent nozzle unit 106 moves along the track 110 under the control of the computer, takes reagent from the reagent bottle at the reagent bottle collection position on the reagent table 104, and ejects reagent to the cuvette at the dispensing position of the cuvette on the LPIA table 108. Like this, the reagent nozzle unit 106 can move in a straight line between the designated position on the reagent table 104 and the designated position on the LPIA table 108 along the track 110. In addition, in the plan view, the collection position is arranged at the intersection of the path of the linear movement of a nozzle 1062 of the reagent nozzle unit 106 according to the present embodiment and the track of the outer peripheral side of the cuvette of the double annular configuration of the reagent table 104, and can also be arranged at the intersection of the path of the linear movement of another nozzle 1062 of the two reagent nozzle units 106 according to the present embodiment and the track of the inner peripheral side. Furthermore, in a plan view, the dispensing positions are respectively provided at intersections of the paths along which the two reagent nozzle units 106 move in a straight line and the orbit of the cuvette arranged in a ring shape in the LPIA stage 108 when rotating.

[0056] Fig. 91 is a diagram showing an embodiment of a coagulation table. The coagulation table 107 is, for example, a table for placing a cuvette when measuring the blood coagulation time. The coagulation table 107 has a plurality of holding holes 1072 that are linear in a direction substantially perpendicular to the extension direction of the track 110, for holding the cuvette. In addition, a light source 1073 is arranged on one side of the cuvette, and a light receiving unit 1074 is arranged on the other side in such a manner that the cuvette held in the holding holes 1072 is sandwiched therebetween. Then, the coagulation degree of the contents in the cuvette is measured based on the light absorbance or transmittance of the contents in the cuvette to a specified wavelength. In addition, the coagulation table 107 has a driving unit 1075 that slides the coagulation table in a direction substantially perpendicular to the extension direction of the track 110. Thus, the desired holding hole 1072 can be moved to a loading and unloading position 1071 located at the intersection with the moving track of the cuvette chuck unit 109. In addition, the cuvette chuck unit 109 can hold the cuvette in the holding hole 1072 at the designated loading and unloading position 1071, or remove the cuvette from the holding hole 1072. The cuvette into which the sample is dispensed in the holding hole of the LPIA stage 108 is transported to the holding hole 1072 of the solidification stage 107 by the cuvette chuck unit 109. In addition, the light source 1073 and the light receiving unit 1074 are provided only in the number of the holding holes 1072, and the holding holes 1072, the light source 1073, and the light receiving unit 1074 move as a whole. Therefore, the absorbance of each cuvette can be continuously measured even during the stage movement.

[0057] Fig.10 A diagram showing an embodiment of an LPIA stage. The LPIA stage 108 is, for example, a stage for placing a cuvette when performing an antigen quantity determination based on a latex agglutination method. The LPIA stage 108 is a disk-shaped stage that rotates around a designated rotation axis 1083, and is provided with a plurality of holding holes 1084 for holding the cuvette in a ring shape along the circumference. Based on computer control, the LPIA stage rotates clockwise or counterclockwise and stops at a designated position. In addition, a spring 1085 for pressing the cuvette is provided in each holding hole 1084.

[0058] Fig.11 A diagram showing an embodiment of a cuvette chuck unit is shown. The cuvette chuck unit 109 is a unit having a two-finger gripper 1091 at its front end and holding and conveying a cuvette. In addition, the cuvette chuck unit 109 moves in a straight line in the horizontal direction along the track 110, and holds or drops the cuvette at the loading and unloading position of the reagent table 104 and the LPIA table 108, the cuvette supply port 1021, the cuvette waste port 111, etc.

[0059] Fig. 12A 1 is a plan view showing an embodiment of a track including a cuvette chuck unit and a reagent nozzle unit. Fig. 12B1 is a front view showing an embodiment of a track having a cuvette chuck unit and a reagent nozzle unit. The track 110 is a track-shaped component, which is connected to the reagent nozzle unit 106 and the cuvette chuck unit 109, and serves as a guide when the reagent nozzle unit 106 and the cuvette chuck unit 109 move. That is, in the composite analysis device 1000, the loading and unloading positions of the reagent table 104, the solidification table 107 and the LPIA table 108, the cuvette supply port 1021, and the cuvette waste port 111 are arranged on a straight line roughly parallel to the track 110. In addition, the collection position 1041 of the reagent table 104, the reagent dispensing position 1076 of the solidification table 107, and the reagent dispensing position 1082 of the LPIA table 108 are also arranged on a straight line roughly parallel to the track 110. In addition, the nozzle 1062 of the reagent nozzle unit 106 and the two-finger clamp 1091 of the cuvette chuck unit 109 move up and down in the vertical direction. However, it is not necessary to move in the front-to-back (front or depth) direction. The reagent nozzle unit 106 and the cuvette chuck unit 109 are connected to the front side of the track 110 and move with the common track 110. For example, after the cuvette chuck unit 109 is retreated to the left side in the front view and the front view, the nozzle 1062 of the reagent nozzle unit 106 can be moved to the dispensing position 1082 of the LPIA station 108. In addition, for example, after the reagent nozzle unit 106 is retreated to the right side in the plan view and the front view, the two-finger gripper 1091 of the cuvette chuck unit 109 can be moved to the cuvette supply port 1021 of the cuvette supply unit 102.

[0060] In addition, the cuvette waste port 111 is an inlet into which the cuvette is placed by the cuvette chuck unit 109 so that the cuvette can be collected in a waste box contained in a storage unit 2 such as a box. A tube for guiding the discarded cuvette from the cuvette waste port 111 toward the top of the waste box can also be provided in the storage unit 2 such as a box.

[0061] The sensor for measuring the contents of the coagulation stage 107 and the cuvette set in the coagulation stage, and the sensor for measuring the contents of the cuvette set in the LPIA stage 108 and the cuvette set in the LPIA stage are one embodiment of the measurement unit for respectively performing designated measurements. In the present invention, one is referred to as a "first measurement unit" and the other is referred to as a "second measurement unit". In addition, the cuvette chuck unit 109 is also referred to as a "transport unit".

[0062] <Effect>

[0063] According to this embodiment, in the case of a random measurement in which the order of the test items to be measured can be freely specified by a composite analysis device having a plurality of measurement units, by setting the movement of the cuvette chuck unit 109 and the reagent nozzle unit 106 to a simple linear motion, the transfer mechanism can be miniaturized and power saving can be achieved while suppressing the overall cost of the device. In addition, the track 110 can be shared by the cuvette chuck unit 109 and the reagent nozzle unit 106, thereby suppressing the enlargement of the overall device. In addition, it is possible to use it efficiently within the specified measurement time and space, thereby achieving a high measurement processing capacity.

[0064] <Analysis Processing>

[0065] When performing, for example, latex agglutination assay, the LPIA stage 108 is rotated and stopped after the designated holding hole is moved to the loading and unloading position. In addition, the cuvette chuck unit 109 grasps a cuvette from the cuvette supply port 1021, moves it to the holding hole at the loading and unloading position of the LPIA stage 108, and holds it in the holding hole. Then, the holding hole holding the cuvette moves to the designated dispensing position. In addition, the loading and unloading position and the dispensing position can be the same. In addition, the sample rack 1011 is transported so that the desired blood collection tube moves to the designated collection position. Then, the sample nozzle unit 103 collects the sample from the blood collection tube pre-retained on the sample rack 1011 at the collection position, and ejects it into the cuvette at the dispensing position of the LPIA stage 108. In addition, while the reagent stage 104 rotates, the front end of the reagent cover opening and closing unit 105 moves at a designated time to contact the cover of the reagent bottle, and opens the designated reagent bottle pre-stored in the reagent stage 104. Then, the uncapped reagent bottle moves to the designated collection position. At this time, the reagent nozzle unit 106 collects the reagent at the designated collection position, and sprays the reagent into the cuvette at the dispensing position of the LPIA platform 108. Then, while the reagent platform 104 rotates, the lid of the reagent bottle is closed by the front end of the reagent cover opening and closing unit 105. In addition, the reagent cover opening and closing unit 105 presses the lid downward from the vertical upper part of the reagent bottle to achieve closed lid. In addition, the LPIA platform 108 rotates to move the cuvette to the designated stirring position. At the stirring position, the stirring rod is inserted into the recessed portion arranged at the bottom of the cuvette from the vertical lower part, and the front end of the stirring rod is displaced in a circle on the horizontal plane, thereby stirring the contents of the cuvette. In addition, multiple reagents can also be dispensed. When using multiple reagents, the first reagent can be sprayed into the cuvette before dispensing the sample, or it can be sprayed after dispensing the sample. The second reagent can be sprayed into the cuvette after dispensing the sample, for example. Furthermore, by the rotation of the LPIA stage 108, the cuvette passes through the optical measurement section formed by the light source and the light receiving section, and the optical measurement section measures changes based on the reaction of the content based on the transmittance, absorbance, scattered light, etc. of a specific wavelength. When the specified measurement is completed, the cuvette is taken out from the holding hole by the cuvette chuck unit 109 at the loading and unloading position of the LPIA stage 108. In addition, the cuvette chuck unit 109 transports the taken out cuvette to the cuvette disposal port 111 and discards it. This processing can be performed in parallel on a plurality of cuvettes held in the LPIA stage 108.

[0066] In addition, when performing, for example, a coagulation time measurement, the coagulation stage 107 slides and stops after the designated holding hole moves to the loading and unloading position. In addition, the cuvette chuck unit 109 holds a cuvette from the cuvette supply port 1021, moves it to the holding hole at the loading and unloading position of the LPIA stage 108, and holds it in the holding hole. Then, the holding hole holding the cuvette moves to the designated dispensing position. In addition, the loading and unloading position and the dispensing position may also be the same. In addition, the sample rack 1011 is transported so that the desired blood collection tube moves to the designated collection position. Then, the sample nozzle unit 103 collects the sample from the blood collection tube pre-held in the sample rack 1011 at the collection position, and ejects it into the cuvette at the dispensing position of the LPIA stage 108. Then, the holding hole holding the cuvette moves to the loading and unloading position of the LPIA stage 108, and the cuvette is held by the cuvette chuck unit 109 and transferred to the loading and unloading position of the coagulation stage 107. In addition, while the reagent table 104 rotates, the front end of the reagent cover opening and closing unit 105 moves at a specified time to contact the cover of the reagent bottle, and opens the specified reagent bottle stored in advance in the reagent table 104. Then, the uncapped reagent bottle moves to the specified collection position. In addition, the reagent nozzle unit 106 collects reagent at the specified collection position, and sprays reagent into the cuvette at the dispensing position of the solidification table 107. Then, while the reagent table 104 rotates, the front end of the reagent cover opening and closing unit 105 closes the cover of the reagent bottle. And, the reagent cover opening and closing unit 105 presses the cover downward from the vertical upper part of the reagent bottle, thereby realizing the closed cover. In addition, the solidification table 107 slides, and the cuvette moves to the specified stirring position. At the stirring position, the stirring rod is inserted into the recessed portion arranged at the bottom of the cuvette from the vertical lower part, and the front end of the stirring rod is displaced in a circular manner on the horizontal plane, thereby stirring the contents of the cuvette. In addition, multiple reagents can also be dispensed. When using multiple reagents, the first reagent can be ejected into the cuvette before dispensing the sample, or it can be ejected after dispensing the sample. The second reagent can be ejected into the cuvette after dispensing the sample, for example. In addition, an optical measuring unit formed by a light source and a light receiving unit is provided in each holding hole of the solidification table 107, and the light source and the light receiving unit clamp the cuvette. The optical measuring unit measures the changes based on the coagulation of the contents based on the transmittance and absorbance of a specific wavelength. When the specified measurement is completed, the cuvette is taken out from the holding hole by the cuvette chuck unit 109 at the loading and unloading position of the solidification table 107. In addition, the cuvette chuck unit 109 transports the removed cuvette to the cuvette waste port 111 and discards it. This process can be performed in parallel on multiple cuvettes held in the solidification table 107.

[0067] <Measurement time extension processing>

[0068] Fig.13FIG. 1 is a diagram showing an example of a block diagram of a function of a composite analysis device for measuring the coagulation time of blood. The composite analysis device 1000 measures the coagulation time of blood using a coagulation table 107. Figure 1 The computer 21 in the storage unit 2 such as a box is connected to the sensor provided in the coagulation stage 107 via a signal line. Then, the computer 21 measures the coagulation degree of the blood in the cuvette based on the absorbance of a specified frequency band, for example.

[0069] like Fig.13 As shown, the computer 21 includes a processor 211 and a storage device 212, and is connected to a sensor provided on the coagulation stage 107 via an input / output interface. The coagulation stage 107 includes a light source 1073 that emits light of a specified wavelength, and a light receiving unit 1074 that receives light that has passed through a cuvette held by a cuvette holding hole 1072, and outputs, for example, a voltage or current corresponding to the intensity of the incident light.

[0070] The processor 211 is a computing device such as a CPU (Central Processing Unit), and performs the processing according to the present embodiment by executing a program. Fig.13 The example also shows a functional block in the processor 211. That is, the processor 211 functions as a device control unit 2111, a data acquisition unit 2112, a coagulation determination unit 2113, and an extension determination unit 2114. The device control unit 2111 controls the composite analysis device 1000 so that a designated analysis is performed on the sample based on the user's operation. The data acquisition unit 2112 acquires data output from a unit of the composite analysis device 1000 such as a sensor provided in the coagulation table 107, etc., via a designated input / output interface. The coagulation determination unit 2113 determines the coagulation degree of the blood in the cuvette based on the absorbance of each cuvette obtained from the light receiving unit 1074 of the coagulation table 107. The extension determination unit 2114 determines whether to terminate or extend the measurement of each cuvette based on the determination of the coagulation determination unit 2113 at a designated timing.

[0071] The storage device 212 is, for example, a main storage device such as RAM (Random Access Memory), ROM (Read Only Memory), or an auxiliary storage device such as HDD (Hard-disk Drive), SSD (Solid State Drive), eMMC (embedded Multi Media Card), flash memory, etc. The main storage device is responsible for the working area of ​​the processor 211 and stores raw data output by the sensor, etc. In addition, the auxiliary storage device stores the program according to the present embodiment and the data output by the sensor and other data.

[0072] Fig.14 1 is a processing flow chart showing an embodiment of the measurement time extension process. The data acquisition unit 2112 of the composite analysis device 1000 acquires information indicating the absorbance of each cuvette held in the coagulation stage 107 and stores it in the storage device 212 ( Fig.14:S1). In addition, the coagulation determination unit 2113 and the extension determination unit 2114 determine whether the specified measurement time has passed and determine whether the specimen in the cuvette has coagulated (S2). In the present embodiment, for example, the specified measurement time is set to 210 seconds. In addition, whether coagulation has occurred is determined based on the magnitude relationship between the absorbance and the specified threshold value. When it is determined that the specified measurement time has not passed or the specimen in the cuvette has coagulated (S2: No), the coagulation determination unit 2113 and the extension determination unit 2114 determine whether it is at the specified determination time point and whether coagulation has occurred (S3). In addition, in the present embodiment, for example, the specified determination time point is set to 30 seconds, 60 seconds, 120 seconds, 180 seconds, or 210 seconds. When it is determined that it is not the specified determination time point or the specimen in the cuvette has not coagulated (S3: No), the process returns to S1 and the recording of absorbance continues. On the other hand, when it is determined that it is the designated judgment time point and the specimen in the cuvette has solidified (S3: Yes), the measurement of the cuvette is completed and the process is transferred to S7. On the other hand, in S2, when it is determined that the designated measurement time has passed and the specimen in the cuvette has not solidified (S2: Yes), the measurement time is extended (S4) and the process is transferred to the re-test mode. In the re-test mode, the measurement end time is extended to 360 seconds, and the measurement after 210 seconds is continued (S5). Then, the data acquisition unit 2112 determines whether the measurement is completed (S6). In this step, it is determined whether the extended measurement end time of 360 seconds has passed since the start of the measurement. When it is determined that the measurement end time has not passed (S6: No), the process returns to S5 and the measurement is continued. On the other hand, when it is determined in S6 that the measurement end time has passed (S6: Yes), or when it is determined in S3 that it is the judgment time point and solidified (S3: Yes), the device control unit 2111 discards the cuvette (S7). In this step, the solidification stage 107 slides to move the cuvette after the measurement to the loading and unloading position, and the cuvette chuck unit 109 grasps the cuvette, transfers it to the cuvette disposal port 111, and puts it down.

[0073] In the case of a normal specimen, the time PT required for blood coagulation is about 10 to 12 seconds, and the APTT is about 25 to 40 seconds. In the measurement time extension process, the measurement time (for example, 210 seconds) at the end of the specified reaction is generally used as a reference to determine the replacement schedule of the cuvette placed on the measurement unit, and the measurement time is extended to continue the measurement process when the reference time is exceeded but not yet completed. In this way, there is no need to extend the measurement time of a specimen in advance for safety, thereby suppressing the reduction in the measurement process efficiency. In addition, if the measurement is completed within the reference measurement time and the specified reaction is not completed, the specimen is re-measured, and the efficiency is very poor due to the time spent on the re-measurement and the waste of the specimen that has not completed the reaction. In the case where the reaction has not ended after the initial measurement end time, by adopting the process of continuing the measurement, this embodiment can eliminate the waste of time and the waste of the specimen, thereby improving the processing efficiency. This extension process is not limited to blood coagulation, and can also be applied to the process of judging the degree of progress of a certain reaction. Furthermore, when the reaction is determined to be finished at the designated judgment time point 30 seconds, 60 seconds, 120 seconds, 180 seconds, or 210 seconds before the above-mentioned measurement end time, for example, the storage device 212 may store the result, or the monitor 3 may output the result. In this way, the user can quickly understand the analysis result.

[0074] <Cross-mixing test>

[0075] Fig.15 1 is a diagram showing an embodiment of a functional block diagram supporting the implementation of a cross-mixing test of a complex analysis device. The complex analysis device 1000 uses the sample nozzle unit 103 to prepare a designated sample in the sample cup 1013. And, the coagulation time of the designated sample is measured using the coagulation table 107. In addition, Figure 1 The computer 21 in the storage unit 2 such as a box is connected to the sensor provided in the coagulation stage 107 via a signal line. Then, the computer 21 measures the coagulation degree of the blood in the cuvette based on the absorbance of a specified frequency band, for example.

[0076] The structure of computer 21 Fig.13 The example is basically the same. Fig.15 In, with Fig.13 The same symbols are used for corresponding structures, and the description is omitted. Fig.15Function blocks are also shown in the processor 211. That is, the processor 211 functions as a device control unit 2111, a data acquisition unit 2112, and an output control unit 2115. The device control unit 2111 controls the complex analysis device 1000 based on the user's operation to prepare a specified specimen in the sample cup 1013 using a sample, or to perform a specified analysis on the prepared specimen. The data acquisition unit 2112 obtains data output from a unit of the complex analysis device 1000 such as a sensor provided in the coagulation table 107, etc., via a specified input / output interface. The output control unit 2115 draws, for example, a table and a graph using the acquired data, and outputs it to the monitor 3, etc.

[0077] Fig.16 1 is a processing flow chart showing an embodiment of cross-mixing test support processing. The device control unit 2111 of the complex analysis device 1000 uses the sample nozzle unit 103 to collect samples from the blood collection tube 1012 holding the patient sample and the blood collection tube 1012 holding the normal sample of a healthy person, respectively, and prepares a mixed specimen in a specified ratio in the sample cup 1013 (S11). In this step, the mixed specimen is prepared by mixing in multiple ratios used in general cross-mixing tests. Specifically, the patient sample and the normal sample are prepared into mixed specimens of 9 to 1, 8 to 2, 5 to 5, and 2 to 8. In addition, specimens of 10 to 0, 9 to 1, 8 to 2, 5 to 5, 2 to 8, and 0 to 10 are used in the cross-mixing test. In addition, in this step, the amount that can be used for multiple specimen measurements can be modulated, for example, the amount of specimen required for use in the coagulation time measurement of immediate reaction and delayed reaction can be modulated. For example, in the case of performing a coagulation time measurement of an immediate reaction and a coagulation time measurement of a delayed reaction, at least two test portions (two test pieces) are prepared. Then, the test pieces are used for the "immediate reaction" and the "delayed reaction". The "immediate reaction" is to measure the coagulation time quickly after mixing, and the "delayed reaction" is to measure the coagulation time after incubating the mixed sample at 37 degrees for 2 hours. In the present invention, as the measurement of the coagulation time, the measurement of PT (Prothrombin Time) and / or APTT (Activated Partial Thromboplastin Time) is performed.

[0078] In addition, the data acquisition unit 2112 measures the coagulation time of the immediate reaction (S12). In this step, the mixed sample for the immediate reaction held in the sample cup 1013 in the LPIA station 108 is dispensed into a cuvette, and the cuvette is transferred to the coagulation station 107 to measure the coagulation time. In addition, the above-mentioned measurement time extension process can also be performed during the measurement of the coagulation time.

[0079] In addition, for the mixed sample for delayed reaction, the user heats it at 37 degrees for 2 hours, for example, by using other devices or a temperature adjustment device (not shown) provided by the composite analysis device 1000. In addition, when the sample cup 1013 holding the heated mixed sample is placed on the conveying space 101, the equipment control unit 2111 moves the sample cup 1013 to the collection position of the sample nozzle unit 103 (S13). In addition, in this step, based on the user's operation, the input of identification information of the same mixed sample used in the immediate reaction corresponding to the heated mixed sample is received, and the identification information is associated. From the mixed sample prepared in the sample cup and having an amount that can be used for multiple sample measurements, by using the remaining part after the immediate reaction as the sample for delayed reaction, the dead volume required for aliquoting into the cuvette can be reduced, thereby reducing the amount of sample used.

[0080] In addition, the data acquisition unit 2112 measures the coagulation time of the delayed reaction (S14). In this step, the mixed specimen held in the sample cup 1013 for the immediate reaction is dispensed into a cuvette in the LPIA station 108, and the cuvette is transferred to the coagulation station 107 to measure the coagulation time. In this step, the above-mentioned measurement time extension process can also be performed during the measurement of the coagulation time.

[0081] Then, the output control unit 2115 outputs the immediate reaction coagulation time and the delayed reaction coagulation time (S15). In this step, a graph or a table may be drawn and output to the monitor 3, other computers, the storage device 212, etc.

[0082] Fig.17 FIG. 1 is a diagram showing an example of output measurement results. Fig.17 In the graph, the vertical axis represents the coagulation time, and the horizontal axis represents the mixing ratio of the patient's plasma and normal plasma. In addition, the solid line line graph plots the coagulation time of the immediate reaction, and the dotted line line graph plots the coagulation time of the delayed reaction. In S15, the graph can be output, and a table representing these contents can also be output. In addition, these contents can also be output to the storage device 212 in the form of CSV (Comma-Separated Values) and a file for processing with a specified extended table (table calculation) program.

[0083] In the cross-mixing test support process, the amount of mixed sample required for the immediate reaction and delayed reaction measurements is automatically modulated. The amount that can be used for multiple sample measurements can be modulated, for example, the amount of sample required for use in the clotting time measurement of the immediate reaction and the delayed reaction is modulated. For example, in the case of performing one clotting time measurement of the immediate reaction and one clotting time measurement of the delayed reaction, at least the amount of sample (two samples) for two measurements is modulated. Therefore, it is not necessary for the user to take the trouble to modulate the samples for the immediate reaction and the delayed reaction measurements. In addition, since the samples used for the immediate reaction and the delayed reaction can be modulated together, no error will occur in the preparation of the samples. In addition, since the clotting time measurements of the immediate reaction and the delayed reaction can be performed in the composite analysis device 1000, for example Fig.17 The output results shown are in a form that is easily comparable by the user and thus are useful.

[0084] In addition, the mixing mode is not limited to 10:0, 9:1, 8:2, 5:5, 2:8, and 0:10. For example, it can also be 7 points of 1:0, 9:1, 3:1, 1:1, 1:3, 1:9, and 0:1. In addition, it can also be 5 points of 1:0, 3:1, 1:1, 1:3, and 0:1. In addition, it can also be 3 points of 1:0, 1:1, and 0:1. The graphs in these modes can also show whether they are convex or concave, which can serve as clues to determine the cause of the prolonged coagulation time. By presetting and selecting these modes, the user can easily sort the measurements. In addition, by automatically calculating and displaying the amount of specimen required for each mode, the user can select a mode according to the remaining amount of the specimen.

[0085] <Modification>

[0086] The above embodiments and modifications are merely exemplary, and the present invention is not limited to the above structures. In addition, the contents described in the embodiments and modifications can be combined as much as possible without departing from the scope of the subject and technical idea of ​​the present invention.

[0087] Fig.18 FIG. 1 is a schematic diagram showing an embodiment of a composite analysis device 1000 having three measurement units. The number of the measurement units is not limited to two. Fig.18In the example of , a third measuring unit 112 is added to the left side of the LPIA stage 108 in the plan view. When there are more than three measuring units, the cuvette chuck unit 109 and the reagent nozzle unit 106 move in a straight line along the track 110, and the three measuring units are arranged on a straight line roughly parallel to the track. In this way, the movement of the cuvette chuck unit 109 and the reagent nozzle unit 106 is a simple linear motion, and power saving can be achieved. In addition, the track 110 can be shared by the cuvette chuck unit 109 and the reagent nozzle unit 106, so that the overall device can be miniaturized.

[0088] Furthermore, the present invention includes a method for executing the above-mentioned processing, a computer program, and a computer-readable recording medium recording the program. The recording medium recording the program enables the above-mentioned processing to be performed by causing a computer to execute the program.

[0089] In this article, a computer-readable recording medium refers to a recording medium that can store information such as data and programs and read them from a computer through electrical, magnetic, optical, mechanical or chemical effects. Among such recording media, those that can be taken out of a computer include a floppy disk, a magneto-optical disk, an optical disk, a magnetic tape, a memory card, etc. In addition, recording media fixed to a computer include HDD, SSD (Solid State Drive), ROM, etc.

[0090] Explanation of symbols

[0091] 1000: Composite analysis device

[0092] 1: Measurement unit storage unit

[0093] 101: Transport Space

[0094] 1011: Sample rack

[0095] 1012: Sample container

[0096] 102: Cuvette supply unit

[0097] 1021: Cuvette supply port

[0098] 1022: Hopper

[0099] 103: Sample nozzle unit

[0100] 1031: betting position

[0101] 1032: Nozzle cleaning tank

[0102] 1033: Rotation axis

[0103] 1034: Nozzle

[0104] 104: Reagent table

[0105] 1041: Collection location

[0106] 1042: Setting Department

[0107] 1043: convex part

[0108] 105: Reagent cover opening and closing unit

[0109] 1051: Front end

[0110] 106: Reagent nozzle unit

[0111] 1061: Nozzle cleaning tank

[0112] 1062: Nozzle

[0113] 107: Solidification table

[0114] 1071: Loading and unloading position

[0115] 1072: Keep hole

[0116] 1073: Light Source

[0117] 1074: Light Receiving Department

[0118] 1075: Drive unit

[0119] 1076: betting position

[0120] 108: LPIA

[0121] 1081: Loading and unloading position

[0122] 1082: betting position

[0123] 1083: Rotation axis

[0124] 1084: Keep hole

[0125] 1085: Spring

[0126] 109: Cuvette chuck unit

[0127] 1091: Two-finger gripper

[0128] 110: Track

[0129] 111: Cuvette waste port

[0130] 112: The third measurement unit

[0131] 2: A storage unit such as a box

[0132] 3: Monitor

[0133] 4: Status output unit

Claims

1. An analysis device, comprising: a sample nozzle unit, which collects the biological sample from a container containing the biological sample at a designated sample collection position and dispenses the sample into a cuvette at a designated sample dispensing position; a first measurement unit, the first measurement unit holding a cuvette dispensed with the biological sample and performing a first measurement on the content of the cuvette; a second measurement unit that holds the cuvette and performs a second measurement different from the first measurement on the contents of the cuvette; a transport unit, the transport unit holding the cuvette and transporting the cuvette to a loading and unloading position of the first measuring unit or a loading and unloading position of the second measuring unit; a reagent table holding a plurality of reagent containers for holding reagents; as well as a reagent nozzle unit that collects the reagent from the reagent container at a designated reagent collection position and dispenses the collected reagent into the cuvette held in the first measuring unit or the second measuring unit at a designated reagent dispensing position, The conveying unit moves along a guide rail, and in a plan view, a loading and unloading position of the first measuring unit and a loading and unloading position of the second measuring unit are arranged on a line along the guide rail. The reagent nozzle unit moves along the guide rail, and the reagent collection position and the reagent dispensing position are arranged on a line parallel to the guide rail. The reagent nozzle unit and the transport unit are connected to one of the guide rails and move by sharing the guide rail. The sample nozzle unit moves the nozzle along a circular arc track in a plan view with a designated rotation axis as the center. The analysis device further includes a supply unit for supplying the cuvette from a supply port, the supply unit including: a hopper for storing the cuvette; and the supply port is the end of the inclined outlet, The supply port of the supply unit, the attachment and detachment position of the first measurement unit, and the attachment and detachment position of the second measurement unit are arranged on the line.

2. The analysis device according to claim 1, further comprising a waste port for discarding the cuvette, The disposal port, the attachment and detachment position of the first measurement unit, and the attachment and detachment position of the second measurement unit are arranged on the line.

3. The analysis device according to claim 1 or 2, further comprising a reagent nozzle cleaning tank for cleaning the reagent nozzle disposed in the reagent nozzle unit. Like the reagent collecting position and the reagent dispensing position, the reagent nozzle cleaning tank is arranged on a line parallel to the guide rail. The analysis device according to claim 1 or 2, wherein the guide rail is arranged in a straight line.

5. The analysis device according to claim 1 or 2, wherein the first measuring unit outputs data indicating the progress of a specified reaction occurring in the contents of the cuvette, The analysis device further includes a processor that, when it is determined based on data output from the measurement unit that the designated reaction has not been completed after a predetermined measurement time has elapsed, extends the measurement time to continue the measurement process.

6. The analysis device according to claim 5, wherein the designated reaction is blood coagulation.

7. The analysis device according to claim 1 or 2, further comprising a dispensing mechanism and a processor, wherein the dispensing mechanism collects the biological sample from a container containing the biological sample and dispenses the biological sample into a sample cup; The first measuring unit holds a cuvette containing the sample dispensed from the sample cup, and measures the coagulation time of the content of the cuvette; The processor causes the dispensing mechanism to prepare a mixed sample of a normal sample and a patient sample in the sample cup, wherein the mixed sample is obtained by mixing the normal sample and the patient sample contained in different containers in an amount that can be used for multiple specimen measurements and in a specified ratio, and the processor causes the first measurement unit to use the prepared mixed sample to perform an immediate coagulation time measurement.

8. The analysis device according to claim 7, further comprising an input / output device, wherein the input / output device inputs and outputs information based on user operation. The processor causes the first measuring unit to measure the coagulation time using the mixed sample heated for a specified time, and receives, via the input-output device, an input of a correspondence between the mixed sample for which the immediate coagulation time measurement was performed and the mixed sample for which the coagulation time measurement was performed after being heated for a specified time, and the processor obtains information related to the coagulation time measured for the corresponding mixed sample from the first measuring unit, and causes the input-output device to output the information.

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