Device, kit and method for repairing and fixing articular cartilage

Abstract

The present invention provides a device, a kit and a method for repairing and fixing articular cartilage, the device comprises a rib cartilage rod, an outer sleeve, a drilling component and an auxiliary implant component; the drilling component comprises a drill sleeve and a drill bit matching the inner diameter of the drill sleeve; the auxiliary implant component comprises a cartilage rod sleeve and an auxiliary propulsion member, the rib cartilage rod is a rod-shaped structure processed from rib cartilage into a diameter of 3-8mm and less than the inner diameter of the cartilage rod sleeve, and is derived from autologous, allogeneic or xenogeneic rib cartilage. The device uses rib cartilage to process the cartilage rod, which can form a good biological bonding interface with the articular cartilage to be fixed and the cancellous bone of the bone bed, and the rib cartilage that can be taken is sufficient, easy to cut and shape, and can be mass-produced; the surface of the cartilage rod can be shaped with the articular surface by cutting, and has biomechanical properties similar to articular cartilage. The method provided by the present invention is highly operable, simple and fast, and provides a new strategy for the restorative treatment of related femoral cartilage injuries.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, in particular to a device, a kit and a method for repairing and fixing articular cartilage. Background Art

[0002] Bone nails are used for fixation of human fractures, spine, etc., especially for fixing small bone fragments together. The existing patent with application number EP89305627.5 discloses a bone needle. In order to solve the technical problem that the fragments are easily dislocated after the drill bit is removed, the bone nail is designed to be inserted into the part to be fixed in the form of a bone rod. In addition, it uses a polymer material that can be absorbed in the body. However, during the implementation process, the biological histology and mechanical properties of the product provided by the patent are very different from those of articular cartilage, and it is impossible to effectively repair and fix the bone cartilage of the designed joint surface.

[0003] Costal cartilage is a hyaline cartilage with very few cells itself, and the cells are embedded in the cartilage matrix, which has an immune shielding effect; the main components, chondroitin sulfate and collagen, are safe ingredients and can be used as implant materials, and the content of other components is also very small. At present, costal cartilage transplantation has been routinely used in the reconstruction of the external ear and trachea, and the costal cartilage junction is used for the repair and reconstruction of cartilage injuries in the interphalangeal joints, metacarpophalangeal joints, mandibular joints, elbow joints and wrist joints. In addition, invention patents with application numbers 201910330808.9 and 201310192619.2 disclose the use of costal cartilage to repair articular cartilage defects. Its mechanical properties are similar to those of articular cartilage, there is almost no immune rejection reaction, and the costal cartilage can form a stable biological bond with the bone bed.

[0004] In summary, rib cartilage is suitable for repairing and fixing articular cartilage, such as fragmented or stripped articular surface osteochondral bone blocks, autologous transplantation to repair osteochondral columns, etc. However, there are currently no reports on cutting rib cartilage into cartilage rods or cartilage needles for fragmented or stripped articular surface osteochondral bone blocks, autologous transplantation to repair osteochondral columns, etc. In addition, the device to assist in the fixation of cartilage rods also needs to be improved. Summary of the invention

[0005] In view of the shortcomings of the prior art, the present invention provides a device, a kit and a method for repairing and fixing articular cartilage. The surface of the cartilage rod can be shaped with the articular surface by cutting and has similar biomechanical properties to articular cartilage; the deep part of the cartilage rod forms a biological osteochondral interface with the cancellous bone of the bone bed, achieving stable long-term biological fixation. This method greatly improves the biological properties of the articular surface cartilage fixation material and can avoid the phenomenon of osteochondral dislocation during the operation.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] A first aspect of the present invention provides a device for repairing and fixing articular cartilage, comprising a rib cartilage rod, an outer sleeve, a drilling component and an auxiliary implant component;

[0008] The drilling component comprises a drill sleeve and a drill bit matching the inner diameter of the drill sleeve;

[0009] The auxiliary implant component includes a cartilage rod sleeve and an auxiliary propulsion member.

[0010] Furthermore, the above-mentioned rib cartilage rod is a rod-shaped structure processed from rib cartilage into a diameter of 3-8 mm and smaller than the inner diameter of the cartilage rod sleeve.

[0011] Furthermore, the above-mentioned costal cartilage is derived from autologous costal cartilage, allogeneic costal cartilage or xenogeneic costal cartilage.

[0012] Furthermore, the bottom end of the outer sleeve is provided with saw teeth to prevent sliding.

[0013] Furthermore, the outer diameters of the drill sleeve and the cartilage rod sleeve are the same as the inner diameter of the outer sleeve.

[0014] Furthermore, a limiting component is fixed to the upper ends of the drill sleeve and the cartilage rod sleeve.

[0015] Furthermore, the outer sleeve, the drill sleeve and the cartilage rod sleeve are made of metal.

[0016] Furthermore, the auxiliary propulsion member is a metal cylinder, the diameter of which is less than or equal to the diameter of the costal cartilage rod.

[0017] Furthermore, a handle is provided at the top of the metal cylinder; the handle is in the shape of a round pancake or a rectangular parallelepiped.

[0018] The second aspect of the present invention provides a kit for repairing and fixing articular cartilage, which includes the device provided in the first aspect and parts for fixing and engaging the various components in the above-mentioned device.

[0019] Furthermore, the above-mentioned kit also includes a gradient cartilage rod; the gradient cartilage rod is prepared by mixing chitosan and HA.

[0020] The third aspect of the present invention is to provide a method for repairing and fixing articular cartilage using the kit provided in the second aspect, comprising the following steps:

[0021] Step 1: Apply force to fix the outer sleeve to the articular cartilage to be fixed, insert the drill bit into the drill sleeve, and then embed the drill sleeve into the outer sleeve to drill according to the required depth;

[0022] Step 2: After the drilling is completed, the drill sleeve is removed, and the rib cartilage rod with the cartilage rod sleeve is inserted into the outer sleeve, and the rib cartilage rod is implanted into the drilled hole using an auxiliary pusher;

[0023] Step 3: Remove the device and cut the costal cartilage rod until it is flush with the joint surface.

[0024] Further, the depth of entry of the drill bit is greater than or equal to the length of the costal cartilage rod retained in the articular cartilage to be fixed.

[0025] Furthermore, the above method also includes using a gradient cartilage rod to perform auxiliary fixation in the non-load-bearing area of ​​the articular cartilage to be fixed.

[0026] The present invention adopts the above technical solution, and has the following technical effects compared with the prior art:

[0027] The device provided by the present invention uses rib cartilage to process into a cartilage rod, which can form a good biological bonding interface with the articular cartilage and bone bed to be fixed, and the available rib cartilage is sufficient, easy to cut and shape, and can be mass-produced. In addition, the surface of the cartilage rod can be shaped with the articular surface by cutting, and has similar biomechanical properties as articular cartilage; the deep part of the cartilage rod forms a biological osteochondral interface with the cancellous bone of the bone bed, achieving stable long-term biological fixation. The method provided by the present invention is highly operable, simple and rapid, and provides a new strategy for the restorative treatment of related femoral cartilage injuries. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic structural diagram of an outer sleeve in a device for repairing and fixing articular cartilage in one embodiment of the present invention;

[0029] Figure 2 It is a schematic diagram of the assembly of the drilling component in the device for repairing and fixing articular cartilage in one embodiment of the present invention;

[0030] Figure 3 It is a schematic structural diagram of an auxiliary implant component (without and with a rib cartilage rod inserted) in a device for repairing and fixing articular cartilage in one embodiment of the present invention;

[0031] Figure 4 It is a schematic structural diagram of an auxiliary propulsion member in a device for repairing and fixing articular cartilage in one embodiment of the present invention;

[0032] Figure 5 It is a schematic diagram of the assembly of a rib cartilage rod when an auxiliary propulsion member is used to implant the rib cartilage rod in one embodiment of the present invention;

[0033] Figure 6 A flow chart of a method for repairing and fixing articular cartilage in one embodiment of the present invention;

[0034] Among them, 1-outer sleeve, 11-saw teeth, 2-drill sleeve, 21-first limiting component, 3-drill bit, 4-cartilage rod sleeve, 41-second limiting component, 5-rib cartilage rod, 6-auxiliary propulsion member. DETAILED DESCRIPTION

[0035] Animal experiments in the inventor's previous research have confirmed that after transplantation, the costal cartilage can form a stable biological combination with the bone bed, and the absorbable material finally leaves a cavity. In addition, based on the fact that the costal cartilage is similar in mechanics and histology, is not easy to cause osteoarthritis, has an immune shielding type, is not easy to cause immune rejection, and is easy to cut and shape, and has a wide range of sources, the present invention provides a device for repairing and fixing articular cartilage. The device includes a costal cartilage rod 5, an outer sleeve 1, a drilling component, and an auxiliary implant component;

[0036] The drilling component comprises a drill sleeve 2 and a drill bit 3 matching the inner diameter of the drill sleeve;

[0037] The auxiliary implant component includes a cartilage rod sleeve 4 and an auxiliary propulsion member 6;

[0038] The outer diameters of the drill sleeve 2 and the cartilage rod sleeve 4 are both the same as the inner diameter of the outer sleeve 1 .

[0039] In a preferred embodiment of the present invention, the costal cartilage rod 5 is a rod-shaped structure processed from costal cartilage into a diameter of 3-8 mm and smaller than the inner diameter of the cartilage rod sleeve 4 .

[0040] In a preferred embodiment of the present invention, the costal cartilage is derived from one of autologous costal cartilage, allogeneic costal cartilage or xenogeneic costal cartilage. When autologous costal cartilage is used, the costal cartilage is from 5 to 7 ribs, preferably the 6th costal cartilage on the right side; when allogeneic or xenogeneic costal cartilage is used, the cartilage is costal cartilage at any level.

[0041] In a preferred embodiment of the present invention, the bottom end of the outer sleeve 1 is provided with saw teeth 11 evenly arranged around a circle to prevent sliding.

[0042] In a preferred embodiment of the present invention, a limiting component is fixed to the upper end of the drill sleeve 2 and the cartilage rod sleeve 4 to prevent overextension of the drill sleeve 2 and the cartilage rod sleeve 4 during operation from causing unnecessary load-bearing and damage to the bone joints, and also to facilitate force application and observation when there is only one medical staff member.

[0043] In a preferred embodiment of the present invention, the outer sleeve 1, the drill sleeve 2 and the cartilage rod sleeve 4 are made of metal.

[0044] In a preferred embodiment of the present invention, the auxiliary propulsion member 6 is a metal cylinder, the diameter of which is equal to or slightly smaller than the diameter of the costal cartilage rod 5 .

[0045] The present invention also provides a kit for repairing and fixing articular cartilage, which comprises the above device and parts for fixing and engaging various components in the device.

[0046] In a preferred embodiment of the present invention, the kit further comprises a gradient cartilage rod; the gradient cartilage rod is prepared by mixing chitosan and HA.

[0047] In addition, the present invention also provides a method for repairing and fixing articular cartilage using the above device or kit.

[0048] The present invention is described in detail and specifically below through specific embodiments and drawings to provide a better understanding of the present invention, but the following embodiments do not limit the scope of the present invention.

[0049] Example 1

[0050] like Figure 1-5 As shown, this embodiment provides a device for repairing and fixing articular cartilage, which includes a rib cartilage rod 5, an outer sleeve 1, a drilling component and an auxiliary implant component;

[0051] like Figure 1 As shown, the bottom end of the outer sleeve 1 is provided with uniformly arranged serrations 11 to prevent sliding; the outer sleeve 1 is made of metal;

[0052] like Figure 2 As shown, the drilling component includes a drill sleeve 2 whose length is slightly less than or equal to that of the outer sleeve 1 and a drill bit 3 matching the inner diameter of the drill sleeve; a first limiting component 21 is provided at the upper end of the drill sleeve 2, and the limiting component 21 is a raised collar structure, which can be integrally formed with the drill sleeve 2, and both are made of metal; the length of the drill bit 3 is greater than that of the drill sleeve 2, and the diameter of the drill bit 3 is equal to the inner diameter of the drill sleeve 2;

[0053] like Figures 3 to 5 As shown, the auxiliary implant component includes a cartilage rod sleeve 4 and an auxiliary propulsion member 6, the length of which is slightly less than or equal to that of the outer sleeve 1; wherein, a second limiting component 41 is provided at the upper end of the cartilage rod sleeve 4, and the limiting component 41 is a raised collar structure, which can be integrally formed with the cartilage rod sleeve 4, and both are made of metal; the length of the rib cartilage rod 5 is less than or equal to the length of the cartilage rod sleeve 4, and the diameter is equal to slightly less than the inner diameter of the cartilage rod sleeve 4 and equal to the diameter of the drill bit 3, and the rib cartilage rod 5 is made of rib cartilage (selected from one of autologous rib cartilage, allogeneic rib cartilage and xenogeneic rib cartilage) and is cut into a rod-shaped structure with a diameter of 3-8 mm, and its diameter and length can be processed according to actual needs;

[0054] In addition, the auxiliary propulsion member 6 is a metal cylinder, the diameter of which is slightly smaller than or equal to the diameter of the costal cartilage rod 5, and a handle is provided at the top thereof; the handle is in the shape of a round pancake or a rectangular parallelepiped.

[0055] Example 2

[0056] refer to Figure 6This embodiment provides a method for fixing a stripped articular surface osteochondral bone block using the device provided in Example 1, comprising the following steps:

[0057] Step 1: Apply force to fix the outer sleeve 1 on the articular cartilage to be fixed, insert the drill bit 3 into the drill sleeve 2, and then embed the drill sleeve 2 into the outer sleeve 1 to drill a hole according to the required depth;

[0058] Step 2: After drilling, remove the drill sleeve 2, insert the rib cartilage rod 5 with the cartilage rod sleeve 4 into the outer sleeve 1, use the auxiliary pusher 6 to align the rib cartilage rod 5, and apply force to implant the rib cartilage rod 5 into the drilled hole;

[0059] Step 3, remove the device and cut the portion of the costal cartilage rod 5 outside the articular surface to make it flush with the articular surface.

[0060] Example 3

[0061] This embodiment provides a kit for repairing and fixing articular cartilage, which includes the device provided in Example 1 (such as Figure 1-5 ) also includes parts for fixing and engaging the various components in the device and a plurality of gradient cartilage rods, wherein the gradient cartilage rods are prepared by mixing chitosan and HA.

[0062] Example 4

[0063] This embodiment uses the kit provided in Example 3 to fix the fragmented articular surface osteochondral bone fragment, comprising the following steps:

[0064] Step 1: Apply force to fix the outer sleeve 1 on the load-bearing part of the articular cartilage to be fixed, insert the drill bit 3 into the drill sleeve 2, and then embed the drill sleeve 2 into the outer sleeve 1 to drill the articular cartilage to be fixed according to the required depth;

[0065] Step 2: After drilling, remove the drill sleeve 2, insert the rib cartilage rod 5 with the cartilage rod sleeve 4 into the outer sleeve 1, align the auxiliary propulsion member 6 with the rib cartilage rod 5, and apply force to implant the rib cartilage rod 5 into the drilled hole;

[0066] Step 3, remove the device, and cut the portion of the costal cartilage rod 5 outside the articular surface to make it flush with the articular surface;

[0067] Step 4: Using the operating methods of steps 1 to 3 above, the costal cartilage rod 5 is replaced with a gradient cartilage rod to assist in reinforcing the articular cartilage at the non-load-bearing position.

[0068] The specific embodiments of the present invention are described in detail above, but they are only examples, and the present invention is not limited to the specific embodiments described above. For those skilled in the art, any equivalent modifications and substitutions made to the present invention are also within the scope of the present invention. Therefore, the equalization changes and modifications made without departing from the spirit and scope of the present invention should be included in the scope of the present invention.

Claims

1. A device for repairing and fixing articular cartilage, It is characterized in that It comprises a rib cartilage rod (5), an outer sleeve (1), a drilling component, an auxiliary implant component, and a gradient cartilage rod; Wherein, the costal cartilage rod (5) is used to fix the load-bearing area of ​​the articular cartilage; The drilling component comprises a drill sleeve (2) and a drill bit (3) matching the inner diameter of the drill sleeve; The auxiliary implant component comprises a cartilage rod sleeve (4) and an auxiliary propulsion member (6); The auxiliary propulsion member (6) is a metal cylinder, the diameter of which is less than or equal to the diameter of the costal cartilage rod (5); The gradient cartilage rod is prepared by mixing chitosan and HA, and is used to assist in fixing the non-load-bearing area of ​​the articular cartilage.

2. The device according to claim 1, It is characterized in that The costal cartilage rod (5) is a rod-shaped structure made from costal cartilage processed into a diameter of 3-8 mm and smaller than the inner diameter of the cartilage rod sleeve (4).

3. The device according to claim 2, It is characterized in that The costal cartilage is derived from autologous costal cartilage, allogeneic costal cartilage or xenogeneic costal cartilage.

4. The device according to claim 1, It is characterized in that The bottom end of the outer sleeve (1) is provided with saw teeth (11) for preventing sliding.

5. The device according to claim 1, It is characterized in that The outer diameters of the drill sleeve (2) and the cartilage rod sleeve (4) are both the same as the inner diameter of the outer sleeve (1).

6. The device according to claim 1, It is characterized in that A limiting component is fixed to the upper ends of the drill sleeve (2) and the cartilage rod sleeve (4).

7. The device according to claim 1, It is characterized in that The outer sleeve (1), the drill sleeve (2) and the cartilage rod sleeve (4) are made of metal.

8. A kit for repairing and fixing articular cartilage, It is characterized in that It comprises the device as described in any one of claims 1 to 7 and parts for fixing and engaging various components in the device.

Images