Preparation method of 17[alpha]-hydroxyprogesterone

By drying, finely grinding and screening the activated carbon in the preparation method of 17α-hydroxyprogesterone, the problem of slow reaction after adding activated carbon in the prior art is solved, the reaction rate and product purity are improved, and the production cost is reduced.

CN112898367AInactive Publication Date: 2021-06-04HEBEI JINSHUI BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEBEI JINSHUI BIOTECHNOLOGY CO LTD
Filing Date
2021-03-08
Publication Date
2021-06-04
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

⚠Technical Problem

In the existing preparation method of 17α-hydroxyprogesterone, the addition of activated carbon is not carefully processed, resulting in slow reaction and long reflux decolorization time, which affects production efficiency and cost.

⚗Method used

By drying, finely grinding and screening the activated carbon, and accurately weighing and screening, the reaction rate of the activated carbon is increased and the reflux decolorization time is shortened. The drying temperature is 60~85°C and the drying time is 10-15 minutes. Fine grinding Afterwards, 0.05W activated carbon ash was screened and decolorized by refluxing for 0.5 to 1 hour to obtain commercial grade 17α-hydroxyprogesterone with an HPLC content of >99.5%.

🎯Benefits of technology

It effectively increases the reaction rate, shortens the reflux decolorization time, reduces the production cost, and improves the yield and purity of the product.

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Abstract

The invention discloses a preparation method of 17[alpha]-hydroxyprogesterone, wherein the preparation method comprises the steps: refining: step 1, dissolving 1 W of a crude product into a mixed solution of 4-5 V dichloromethane and 6-8 V ethanol, and heating to dissolve the crude product; step 2, weighing activated carbon exceeding a preset amount, then putting the activated carbon into a drying device for drying, controlling the drying temperature to be 60-85 DEG C, and controlling the drying time to be 10-15 minutes; and step 3, taking out the activated carbon dried in the step 2, and then placing the activated carbon in a grinding device for fine grinding. According to the scheme, activated carbon in the refining process in an original scheme is finely processed and then added, so that the reaction rate is effectively increased, the time of reflux decoloration is shortened, large-scale production and processing are facilitated, and the production cost is further reduced.
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