Sample needle cleaning station and sample needle cleaning system for biochemical immunoassay

Abstract

The present invention discloses a sample needle cleaning station and a sample needle cleaning system for a biochemical immunometer, wherein the sample needle cleaning system comprises a sample needle cleaning station, the sample needle cleaning station comprises a cleaning container and a cleaning unit, a liquid discharge unit, an overflow unit and an anti-hanging liquid unit arranged on the cleaning container, the upper part of the overflow unit is connected with the cleaning unit and discharges the cleaning liquid overflowing from the cleaning unit; the anti-hanging liquid unit is connected with the upper part of the cleaning unit. The present invention arranges an overflow unit on the cleaning container, and uses the overflow unit and the liquid discharge unit to discharge the cleaning waste liquid together, thereby improving the waste discharge capacity; the upper part of the cleaning container is provided with an anti-hanging liquid unit, and the anti-hanging liquid unit is located above the liquid inlet hole, and the negative pressure provided by the liquid pump on the second liquid discharge pipeline draws away the cleaning liquid remaining on the outer wall of the sample needle, effectively avoiding the cleaning liquid from hanging on the wall, ensuring the cleaning effect of the sample needle, reducing the probability of cross contamination between samples, and improving the reliability and repeatability of the detection results.

Description

Technical Field

[0001] The invention relates to a biochemical immunometer, in particular to a sample adding needle cleaning station used for the biochemical immunometer, and also to a sample adding needle cleaning system having the sample adding needle cleaning station. Background Art

[0002] The cleaning effect of the sample needle directly affects the accuracy, reliability and repeatability of the sample, so the cleaning operation of the sample needle is an indispensable and important part of the detection operation of the automated biochemical immunoassay (such as the fully automatic chemiluminescence immunoassay analyzer). The cleaning station equipped on the existing biochemical immunoassay is a cleaning container with a cleaning chamber. The upper part of the cleaning container has a liquid inlet hole connected to the cleaning chamber and the lower part has a waste liquid hole connected to the cleaning chamber. The waste liquid hole is connected to the waste liquid pipeline of the biochemical immunoassay, and the liquid pump on the waste liquid pipeline is used to extract the cleaning waste liquid in the cleaning chamber. However, after cleaning, there is often liquid remaining on the outer wall and needle tip of the sample needle, that is, the sample needle is not cleaned thoroughly, which not only has the risk of cross-contamination of the sample, but also has the risk of residual cleaning liquid diluting the sample, thereby affecting the reliability and repeatability of the test results. Therefore, how to design a cleaning station that can hang liquid on the outer wall of the sample needle is a technical problem that biochemical immunoassay manufacturers need to overcome. Summary of the invention

[0003] The present invention aims to provide a sample needle cleaning station for a biochemical immunoassay instrument, and also provides a sample needle cleaning system including the sample needle cleaning station, which can utilize negative pressure and an anti-hanging liquid unit to remove droplets remaining on the outer wall of the sample needle, avoid liquid hanging on the outer wall of the sample needle, and effectively ensure the cleaning effect.

[0004] To achieve the above object, the present invention adopts the following technical solutions:

[0005] The sample needle cleaning station for a biochemical immunoassay instrument described in the present invention includes a cleaning container and a cleaning unit and a liquid discharge unit opened on the cleaning container; it also includes an overflow unit and an anti-hanging liquid unit opened on the cleaning container, the upper part of the overflow unit is connected to the cleaning unit to discharge the cleaning liquid overflowed from the cleaning unit, and the anti-hanging liquid unit is connected to the upper part of the cleaning unit.

[0006] In a preferred embodiment of the present invention, the cleaning unit comprises a first overflow trough opened from top to bottom at the upper part of the cleaning container and a cleaning cavity opened along the length direction of the cleaning container, and the upper part of the cleaning cavity extends upward into the first overflow trough.

[0007] In a preferred embodiment of the present invention, the cleaning unit further comprises at least two liquid inlet holes horizontally opened at the upper portion of the cleaning container, and each of the liquid inlet holes is connected to the upper portion of the cleaning chamber via an inclined first connecting channel.

[0008] In a preferred embodiment of the present invention, the anti-hanging liquid unit includes at least one liquid extraction hole opened on the upper part of the cleaning container, the liquid extraction hole is connected to the upper part of the cleaning chamber through a horizontally arranged second connecting channel, and the height of the liquid extraction hole is higher than the height of the liquid inlet hole and lower than the bottom wall of the first overflow tank. In actual processing, the liquid extraction hole is a threaded hole to facilitate the installation of the liquid extraction pipeline.

[0009] In a preferred embodiment of the present invention, the drainage unit includes a waste liquid hole and a third connecting channel horizontally opened at the lower part of the cleaning container, one end of the third connecting channel is connected to the waste liquid hole and the other end is connected to the bottom of the cleaning chamber. During cleaning, waste liquid is discharged through the third connecting channel and the waste liquid hole.

[0010] In a preferred embodiment of the present invention, the cleaning chamber includes an upper expansion section, a truncated cone connecting section that gradually retracts from top to bottom, and a lower cleaning section that extends vertically downward from the bottom of the truncated cone connecting section, and the upper portion of the upper expansion section extends into the first overflow trough. More preferably, a notch with an arc-shaped structure is provided on the upper edge of the upper expansion section, so that the cleaning liquid in the cleaning chamber flows into the first overflow trough through the notch.

[0011] In a preferred embodiment of the present invention, the outlet of the first connecting channel is located on the truncated cone connecting section, and the outlet of the second connecting channel is located on the upper expansion section, thereby ensuring the cleaning effect of the sample addition needle.

[0012] In a preferred embodiment of the present invention, the overflow unit includes a second overflow groove opened on the wall of the first overflow groove, and an overflow cavity opened along the length direction of the cleaning container, the top of the overflow cavity is connected to the second overflow groove and the bottom thereof is connected to the overflow hole opened at the bottom of the cleaning container.

[0013] In a preferred embodiment of the present invention, the cleaning container is formed by connecting an upper cylindrical section and a lower cylindrical section, the diameter of the upper cylindrical section is larger than the diameter of the lower cylindrical section, and a pair of mounting planes are provided on the outer wall of the lower cylindrical section.

[0014] The present invention also provides a sample needle cleaning system, comprising the sample needle cleaning station described in the present invention, and also comprising an injection pipeline connected to the cleaning unit, a first discharge pipeline connected to the overflow unit, a second discharge pipeline connected to the anti-hanging liquid unit, and a third discharge pipeline connected to the discharge unit, the outlets of the first discharge pipeline, the second discharge pipeline and the third discharge pipeline are all connected to a waste liquid container, and the inlet of the injection pipeline is connected to a cleaning liquid storage container.

[0015] The advantage of the present invention is that an overflow unit is provided on the cleaning container, and the overflow unit and the liquid discharge unit are used to discharge the cleaning waste liquid together, thereby improving the waste discharge capacity; at the same time, an anti-hanging liquid unit is provided on the upper part of the cleaning container, and the anti-hanging liquid unit is located above the liquid inlet hole. The negative pressure provided by the liquid pump on the second liquid discharge pipeline can draw away the cleaning liquid remaining on the outer wall of the sampling needle, effectively avoiding the cleaning liquid from hanging on the wall, ensuring the cleaning effect of the sampling needle, thereby reducing the probability of cross contamination between samples, and improving the reliability and repeatability of the detection result. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a structural schematic diagram of the sample adding needle cleaning station of the present invention.

[0017] Figure 2 yes Figure 1 BB section view.

[0018] Figure 3 yes Figure 1 CC section view.

[0019] Figure 4 yes Figure 1 AA section view.

[0020] Figure 5 yes Figure 4 DD section view.

[0021] Figure 6 It is an axonometric diagram of the sample needle cleaning station of the present invention.

[0022] Figure 7 Schematic diagram of the sample needle cleaning station of the present invention.

[0023] Figure 8 It is a pipeline diagram of the sample adding needle cleaning system of the present invention. DETAILED DESCRIPTION

[0024] The following is a detailed description of an embodiment of the present invention in conjunction with the accompanying drawings. This embodiment is implemented on the premise of the technical solution of the present invention, and a detailed implementation method and a specific operation process are given, but the protection scope of the present invention is not limited to the following embodiment.

[0025] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0026] It should also be noted that in the present invention, the descriptions of "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" or "second" may explicitly or implicitly include at least one of the features.

[0027] like Figure 1 As shown, the sample needle cleaning station for biochemical immunoassay instrument of the present invention comprises a cleaning container 1 and a cleaning unit, a drainage unit, an overflow unit and an anti-hanging liquid unit provided on the cleaning container 1, the upper part of the overflow unit is connected to the cleaning unit, and the anti-hanging liquid unit is connected to the upper part of the cleaning unit. During the cleaning process, the internal cleaning waste liquid of the cleaning unit is discharged by the drainage unit, and the cleaning liquid overflowing from the cleaning unit overflows into the overflow unit and is discharged through its overflow hole 5.3, effectively ensuring the cleaning effect of the sample needle; when the needle is pulled upward, the anti-hanging liquid unit draws away the liquid on the outer wall of the sample needle, ensuring the cleaning effect of the sample needle;

[0028] like Figure 4 and Figure 7 As shown, the cleaning unit includes a first overflow trough 2.1 opened from top to bottom on the upper part of the cleaning container 1 and a cleaning chamber opened along the length direction of the cleaning container 1, the cleaning chamber includes an upper expansion section 2.2, a truncated cone connecting section 2.3 gradually contracting from top to bottom, and a lower cleaning section 2.4 extending vertically downward from the bottom of the truncated cone connecting section 2.3, the cross section of the cleaning chamber is larger at the top and smaller at the bottom, which improves the drainage rate of the cleaning waste liquid; the upper part of the upper expansion section 2.2 extends into the first overflow trough 2.1, ensuring that the cleaning waste liquid overflowing from the cleaning chamber can fall into the first overflow trough 2.1, and the bottom of the lower cleaning section 2.4 is connected to the drainage unit;

[0029] like Figure 7 As shown, an arc-shaped notch 2.5 is provided on the upper edge of the upper expansion section 2.2, so that the cleaning waste liquid in the cleaning chamber overflows through the notch 2.5 to the first overflow groove 2.1 below, and then is discharged through the overflow unit, thereby preventing the cleaning waste liquid from overflowing outward and improving the drainage capacity of the cleaning container 1;

[0030] like Figure 1-2 and Figure 6-7 As shown, the cleaning unit further comprises two liquid inlet holes 2.6 horizontally opened on the upper part of the cleaning container 1, each of the liquid inlet holes 2.6 is connected to the truncated cone connecting section 2.3 through an inclined first connecting channel 2.7, the outlet of the inner end of the first connecting channel 2.7 is located on the side wall of the truncated cone connecting section 2.3 and its height is lower than its outer end, and the included angle between the center line of the first connecting channel and the center line of the cleaning container is 80°, so that the cleaning liquid flows into the cleaning chamber from high to low;

[0031] like Figure 4-5As shown, the drainage unit includes a waste liquid hole 3.1 and a third connecting channel 3.2 horizontally opened at the lower part of the cleaning container 1. One end of the third connecting channel 3.2 is connected to the waste liquid hole 3.1 and the other end is connected to the bottom of the lower cleaning section 2.4. The waste liquid in the cleaning chamber is discharged through the third connecting channel 3.2 and the waste liquid hole 3.1.

[0032] like Figure 3 As shown, the anti-hanging liquid unit includes a liquid extraction hole 4.1 horizontally opened on the upper part of the cleaning container 1, and the liquid extraction hole 4.1 is connected to the upper expansion section 2.2 of the cleaning chamber through a horizontally arranged second connecting channel 4.2. The height of the liquid extraction hole 4.1 is higher than the height of the liquid inlet hole 2.6 and lower than the bottom wall of the first overflow groove 2.1, ensuring that the droplets on the sample addition needle can be extracted to ensure the cleaning effect of the sample addition needle.

[0033] In actual processing, the liquid extraction hole 4.1 is a threaded hole to facilitate the installation of a quick-connect plug.

[0034] like Figure 1 and Figure 3 As shown, the overflow unit includes a second overflow groove 5.1 opened on the wall of the first overflow groove 2.1, and an overflow cavity 5.2 opened along the length direction of the cleaning container 1. The top of the overflow cavity 5.2 is connected to the second overflow groove 5.1 and the bottom is connected to the overflow hole 5.3 opened at the bottom of the cleaning container 1, so that the cleaning liquid is discharged through the overflow cavity 5.2 and the overflow hole 5.3.

[0035] In another embodiment of the present invention, this embodiment provides a sample needle cleaning system, such as Figure 8 As shown, the sample needle cleaning system includes the sample needle cleaning station, and also includes a liquid injection pipeline 6.1 connected to the liquid inlet hole 2.6 (the other end of the liquid injection pipeline 6.1 is connected to the cleaning liquid container 6.2, and the liquid injection pipeline 6.1 is provided with a liquid injection pump 6.3), a first liquid discharge pipeline 7.1 connected to the overflow hole 5.3 of the overflow unit (the first liquid discharge pipeline 7.1 is provided with a first liquid extraction pump 7.2), a second liquid discharge pipeline 8.1 connected to the anti-hanging liquid unit (that is, connected to the liquid extraction hole 4.1) (the second liquid discharge pipeline 8.1 is provided with a second liquid extraction pump 7.2), and a liquid injection pipeline 6.1 connected to the liquid injection hole 2.6. The first liquid pump 7.2 and the third liquid pump 8.2 are connected to the liquid discharge unit (i.e., connected to the waste liquid hole 3.1), and the third liquid discharge pipeline 9.1 (the third liquid discharge pipeline 9.1 has a third liquid pump 9.2). The outlets of the first liquid discharge pipeline 7.1, the second liquid discharge pipeline 8.1 and the third liquid discharge pipeline 9.1 are all connected to the waste liquid container F. The first liquid pump 7.2 and the third liquid pump 9.2 can discharge the cleaning waste liquid into the waste liquid container F. The second liquid pump 8.2 can provide negative pressure for the liquid pumping hole 4.1, thereby sucking away the droplets on the outer wall of the sample needle, effectively avoiding the droplets from hanging on the wall.

[0036] When cleaning the inner wall of the sample needle, the sample needle is moved and inserted into the cleaning cavity. The liquid path module of the biochemical immunoassay instrument pumps the cleaning liquid into the inner cavity of the sample needle to clean the inner wall of the sample needle. The waste liquid generated by the cleaning is discharged from the cleaning container 1 through the cleaning cavity and the waste liquid hole 3.1 under the action of the third liquid pump 9.2. If the amount of cleaning liquid used for the inner wall of the sample needle is large, the cleaning waste liquid may overflow from the upper edge of the cleaning cavity during the cleaning process. The overflowed cleaning waste liquid is discharged from the cleaning container 1 through the second overflow groove 5.1, the overflow cavity 5.2 and the overflow hole 5.3 under the action of the first liquid pump 7.2. , effectively preventing the washing waste liquid from overflowing to the outside of the washing container 1, ensuring the normal operation of the instrument; when cleaning the outer wall of the sample adding needle, the liquid injection pipeline 6.1 injects the washing liquid into the washing cavity through the liquid inlet hole 2.6 to clean the outer wall of the sample adding needle, and the waste liquid generated by the washing is discharged from the washing container 1 through the washing cavity and the waste liquid hole 3.1 under the action of the third liquid pump 9.2; the washing waste liquid overflowing from the upper edge of the washing cavity during the washing process is discharged from the washing container 1 through the second overflow groove 5.1, the overflow cavity 5.2 and the overflow hole 5.3 under the action of the first liquid pump 7.2, ensuring the normal operation of the instrument;

[0037] When the inner and outer walls of the sampling needle are cleaned, the sampling needle is lifted upward. During the lifting process, the second liquid extraction pump 8.2 provides negative pressure for the liquid extraction hole 4.1. The negative pressure in the liquid extraction hole 4.1 extracts the droplets on the outer wall of the sampling needle (during the lifting process of the sampling needle, the sampling needle can be lifted and rinsed while the outer wall of the sampling needle is subjected to negative pressure extraction according to actual needs), thereby avoiding droplets from sticking to the wall, improving the cleaning effect of the sampling needle, reducing cross contamination or sample dilution caused by incomplete cleaning of the sampling needle, and improving the reliability and repeatability of the test results.

[0038] It should be emphasized that the above embodiments are only specific implementations of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of various equivalent modifications, replacements and improvements within the technical scope of the present invention, and these modifications and improvements should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention shall be based on the protection scope of the claims.

Claims

1. A sample needle cleaning station for a biochemical immunoassay instrument, comprising a cleaning container and a cleaning unit and a liquid discharge unit disposed on the cleaning container, characterized in that: It also includes an overflow unit and an anti-hanging liquid unit opened on the cleaning container, the anti-hanging liquid unit is connected to the upper part of the cleaning unit; the cleaning unit includes a first overflow trough opened on the upper part of the cleaning container from top to bottom and a cleaning chamber opened along the length direction of the cleaning container, the cleaning chamber includes an upper expansion section, a truncated cone connecting section that gradually retracts from top to bottom, and a lower cleaning section that extends vertically downward from the bottom of the truncated cone connecting section, and the upper part of the upper expansion section extends into the first overflow trough; the cleaning unit also includes at least two liquid inlet holes horizontally opened on the upper part of the cleaning container, each of the liquid inlet holes is connected to the upper part of the cleaning chamber through an inclined first connecting channel; The anti-hanging liquid unit includes a liquid extraction hole opened on the upper part of the cleaning container, and the liquid extraction hole is connected with the upper part of the cleaning chamber through a horizontally arranged second connecting channel. The height of the liquid extraction hole is higher than the height of the liquid inlet hole and lower than the bottom wall of the first overflow groove; the upper part of the overflow unit is connected with the cleaning unit and discharges the cleaning liquid overflowing from the cleaning unit. The overflow unit includes a second overflow groove opened on the wall of the first overflow groove and an overflow chamber opened along the length direction of the cleaning container. The top of the overflow cavity is connected with the second overflow groove and the bottom thereof is connected with the overflow hole opened at the bottom of the cleaning container.

2. The sample needle cleaning station for biochemical immunoassay instrument according to claim 1, characterized in that: The drainage unit comprises a waste liquid hole horizontally opened at the lower part of the cleaning container and a third connecting channel, one end of the third connecting channel is connected to the waste liquid hole and the other end thereof is connected to the lower part of the cleaning chamber.

3. The sample needle cleaning station for biochemical immunoassay instrument according to claim 1, characterized in that: The upper edge of the upper expansion section is provided with a notch in an arc-shaped structure.

4. The sample needle cleaning station for biochemical immunoassay instrument according to claim 2, characterized in that: The cleaning container is formed by connecting an upper cylindrical section and a lower cylindrical section. The diameter of the upper cylindrical section is greater than the diameter of the lower cylindrical section. A pair of mounting planes are provided on the outer wall of the lower cylindrical section.

5. A sample needle cleaning system, characterized in that: It comprises the sample needle cleaning station as described in any one of claims 1 to 4, an injection pipeline connected to the cleaning unit, a first discharge pipeline connected to the overflow unit, a second discharge pipeline connected to the anti-hanging liquid unit and a third discharge pipeline connected to the discharge unit, the outlets of the first discharge pipeline, the second discharge pipeline and the third discharge pipeline are all connected to a waste liquid container, and the inlet of the injection pipeline is connected to a cleaning liquid container.

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