A biomagnetic quantum detection system and detection method thereof and probe bracket

Abstract

The invention discloses a biomagnetic quantum detection system and a detection method thereof and a probe bracket. An atomic magnetic sensor group for measuring the biomagnetic field is composed of a plurality of atomic magnetic sensors, and the atomic magnetic sensor comprises a sensor probe and a sensor controller; the sensor probe comprises a first magnetic sensor probe for collecting background noise and background magnetic field gradient information and a plurality of second magnetic sensor probes for receiving the biomagnetic field; the scheme calculates the common mode magnetic noise at any position in space by collecting the background magnetic noise and its gradient, so as to improve the signal quality at the measuring position, reduce the measurement error, and further improve the accuracy and sensitivity of the biomagnetic detection.

Description

Technical Field

[0001] The invention relates to the technical fields of atomic magnetometers and biomagnetic detection, and in particular to a biomagnetic quantum detection system and a detection method thereof and a probe bracket. Background Art

[0002] During the life activities of the human body, the transfer of electrons or the movement of ions occurs inside or between cells, forming bioelectric current. Human organs such as the heart, brain, and muscles have regular bioelectric current flows, and bioelectric current is accompanied by biomagnetic field. Studies have shown that abnormalities in certain organs or tissues of the human body will lead to changes in bioelectric current. By detecting the biomagnetic field, the characteristics of bioelectric current can be inferred, thereby judging the health status of these organs or tissues.

[0003] The heart magnetic field, brain magnetic field, nerve magnetic field, muscle magnetic field, etc. are all biomagnetic fields. The strength of the biomagnetic field of these organs or tissues in the human body is between 10 -14 ~10 -11 Tesla level. Compared with the Earth's magnetic field strength (10 -5 Tesla level), the human body's biomagnetic field signal is extremely weak. To measure such a weak magnetic field, conventional magnetic field measurement technologies, such as fluxgate and magnetoresistance technology, cannot meet such high precision requirements. The most cutting-edge modern quantum magnetic measurement technologies, including low-temperature superconducting interferometer (SQUID) technology and atomic magnetic measurement technology, can theoretically reach 10 -15 The Tesla level can meet the accuracy requirements of human biomagnetic detection.

[0004] In the past two or three decades, the detection technology and clinical application of human biomagnetic field have developed rapidly. At present, magnetocardiographs and magnetoencephalograms have been put into research and clinical application. Because SQUID engineering technology matured earlier, most of these human biomagnetic field diagnostic equipment use SQUID technology. The core components of this technology need to work in an ultra-low temperature environment of 4K. Usually, liquid helium is filled in a Dewar flask for cooling, resulting in high equipment cost and bulky size. In addition, liquid helium will continue to evaporate and escape during use, and liquid helium needs to be continuously replenished. Therefore, the operation and maintenance costs of the SQUID system are very high, which greatly affects the market application of such equipment.

[0005] Atomic magnetism measurement technology uses alkali metal atoms in a specific quantum state, whose quantum state can sensitively sense the environmental magnetic field and undergo certain changes accordingly. By detecting the changes in the quantum state, the magnetic field strength information can be obtained. Atomic magnetism measurement technology is divided into different implementation methods such as Mx atomic magnetometer, Mz atomic magnetometer, and spin-free relaxation exchange (SERF) magnetometer.

[0006] The engineering difficulty of atomic magnetism measurement technology lies in laser technology. With the mature application of laser technology in the past 20 years, the application of atomic magnetism detection technology has also matured. Because atomic magnetism measurement technology has ultra-high sensitivity and accuracy, it does not require a low-temperature working environment like SQUID, and its size is also developing in the direction of miniaturization, becoming the mainstream direction of current weak magnetic field measurement and application.

[0007] The detection and clinical application of human biomagnetism has always been a cutting-edge technology in the medical field, but it has been limited to weak magnetic field detection technology and has not been widely used. At present, the more mature human biomagnetism detection technology is the detection of heart magnetism and brain magnetism, and it has been put into actual clinical use.

[0008] Patent document with publication number CN109998519 discloses a system for magnetocardiography measurement and magnetocardiography generation based on SERF atomic magnetometer, including: magnetic shielding barrel (room), SERF atomic magnetometer, data acquisition and magnetocardiography generation module. The magnetic shielding barrel (room) is used to shield the earth's environmental magnetic field, so that the SERF atomic magnetometer can work in a zero magnetic environment. The magnetic shielding barrel is made of three layers of Permalloy, which has extremely high weak magnetic field permeability and good plasticity. The SERF atomic magnetometer includes components such as a laser, a collimating lens, a combined lens system, a reflector, an alkali metal gas chamber, a photodetector (PD), and a non-magnetic electric heating system and a magnetic compensation coil system. The light with a wavelength of 795nm output by the laser is introduced into the optical path through an optical fiber, and a beam of parallel light is emitted through a collimating lens, and then converted into circularly polarized light through a combined lens system, namely a polarizer and a 1 / 4 wave plate, and incident on the alkali metal gas chamber through a reflector. The emitted light is then incident on the photodetector PD through a reflector. The alkali metal gas chamber contains alkali metal and inert gas. The alkali metal gas chamber is a sensitive element for sensing the size of the external magnetic field. The circularly polarized light incident on the alkali metal gas chamber polarizes the outermost electrons of the alkali metal in the zero magnetic field. When the external magnetic field is disturbed, the size of the external magnetic field is determined by the output change of the photodetector PD. Alkali metals need to be in a high temperature and non-magnetic environment to obtain a spin-free exchange relaxation state. Therefore, the SERF atomic magnetometer includes a non-magnetic heating system and a magnetic shielding coil system. The non-magnetic heating system heats the gas chamber to raise its temperature to 150 degrees Celsius. The magnetic shielding coil system is used to compensate for the residual magnetism in the magnetic shielding barrel (room). The volume of the SERF atomic magnetometer is 1.8cm×3.15cm×10cm. Its axial direction is its sensitive axis Z axis, which is used to simultaneously measure the cardiac magnetism in the normal direction of the chest surface, and can be close to the skin to achieve shorter distance measurements. The data acquisition module comprises a 6*6 array type magnetocardiographic measurement board, a transmission line and an NI acquisition board, and is specifically implemented as follows: when measuring magnetocardiography, a hard non-magnetic magnetocardiographic measurement board is used, and the magnetocardiographic measurement board has 6*6 SERF atomic magnetometer probe jacks, and the jacks are spaced 1 cm apart; the height of the SERF atomic magnetometer inserted into the jack is adjusted according to the chest height of the subject, so that the SERF atomic magnetometer is closely attached to the surface skin of the chest; the measurement board is tied to the chest of the subject, with the center about a fist distance to the left, so that the center of the measurement board is located directly above the heart; according to the existing number X of SERF atomic magnetometers, X position points on the 6*6 array magnetocardiographic measurement board are measured each time, and the measurement time is about 2 minutes; the NI acquisition board is used to simultaneously collect the Z-axis data of X SERF atomic magnetometers, that is, a total of X data is output each time, and the positions of X probes are changed, and the 36 measurement points on the magnetocardiographic measurement board are traversed in turn through multiple measurements to obtain the magnetocardiographic signals of all position points, i.e., 36 channels.The magnetocardiogram generation module is placed outside the magnetic shielding barrel (room), and includes data bad segment deletion, data preprocessing, single-channel average magnetocardiogram cycle extraction, and magnetocardiogram drawing.

[0009] Biomagnetic detection technology belongs to weak magnetic detection technology, and one of its difficulties is to effectively suppress background noise. In the above-mentioned prior art, although a magnetic shielding barrel (room) is used to shield the earth's environmental magnetic field, it is still impossible to effectively suppress background noise, which has a great impact on the accuracy and sensitivity of biomagnetic detection. In the prior art, there is also a method of collecting the magnetic field information of a point as the background magnetic field and performing differential calculation, but this method cannot extract the background gradient information of the magnetic field. Because of the existence of the magnetic field gradient, the common mode noise of the magnetic field at different positions is different, and the gradient will change over time, which also leads to a large error in this method. Summary of the invention

[0010] In order to solve the above-mentioned technical problems, the purpose of the present invention is to provide a biomagnetic quantum detection system, a detection method and a probe holder, which can calculate the common-mode magnetic noise at any position in space by collecting background magnetic noise and its gradient, so as to improve the signal quality at the measurement position, reduce measurement errors, and further improve the accuracy and sensitivity of biomagnetic detection.

[0011] In order to achieve the above-mentioned purpose, the present invention adopts the following technical solutions:

[0012] A biomagnetic quantum detection system, comprising:

[0013] An atomic magnetic sensor group for measuring biomagnetic field, composed of a plurality of atomic magnetic sensors, wherein the atomic magnetic sensor includes a sensor probe and a sensor controller;

[0014] A magnetic shielding device (5) for shielding external magnetic fields and electromagnetic noise;

[0015] A supporting and positioning mechanical device comprises a base (1), an examination bed assembly (2) for fixing a human body to be examined, and a probe bracket (4) for fixing a sensor probe;

[0016] System control and data processing unit;

[0017] and a system operating unit;

[0018] Wherein, the sensor probe comprises:

[0019] At least three first magnetic sensor probes (41) for collecting background noise and background magnetic field gradient information,

[0020] and a plurality of second magnetic sensor probes (42) for receiving biological magnetic fields;

[0021] The first magnetic sensor probe (41) and the second magnetic sensor probe (42) are both fixed on the probe bracket (4), and the second magnetic sensor probe (42) is located below the first magnetic sensor probe (41).

[0022] Preferably, the probe holder (4) is arranged in the magnetic shielding device (5), and the sensor probe mounted on the probe holder (4) is connected to the sensor controller mounted outside the magnetic shielding device (5) via the sensor cable (6). In this way, the sensor probe is close to the human organ or tissue to receive the human biomagnetic field, and the sensor controller is at a suitable distance from the sensor probe to reduce the interference with the measured biomagnetic field.

[0023] Preferably, three first magnetic sensor probes (41) are arranged on the probe bracket (4), namely probe A, probe B and probe C. Probe A and probe B are arranged up and down along the Z direction, and probe A and probe C are arranged front to back along the Y direction. The plurality of second magnetic sensor probes (42) are located below the first magnetic sensor probes (41) and are arranged in a row front to back along the Y direction. The three first magnetic sensor probes (41) and the plurality of second magnetic sensor probes (42) are located in the same YZ plane. In this way, the coordinates of each probe are known; the measured value of probe B minus the measured value of probe A divided by the distance between AB can be used to obtain the gradient of the magnetic field in the z direction. Similarly, the measured value of probe C minus the measured value of probe A divided by the distance between AC can be used to obtain the gradient of the magnetic field in the y direction; then according to the z projection distance of the multiple probes below from A, and the y projection distance, combined with the calculated gradients in the z and y directions, the background magnetic field at the position of each second magnetic sensor probe below can be calculated; subtracting the calculated background magnetic field from the measured value is equivalent to suppressing the background noise at the measurement position, thereby improving the quality of the signal to be measured. The preferred solution is that multiple second magnetic sensor probes are evenly arranged in a row along the Y direction, and the length of the probe arrangement covers the Y direction scale of the area to be measured. The preferred solution for detecting magnetic cardio signals is to configure 6 to 12 atomic magnetic sensors with a distance of 30 to 50 mm between the probes.

[0024] Preferably, four first magnetic sensor probes (41) are arranged on the probe bracket (4), namely probe A, probe B, probe C and probe D, probe A and probe B are arranged up and down along the Z direction, probe A and probe C are arranged front and back along the Y direction, probe A and probe D are arranged left and right along the X direction, and at least four second magnetic sensor probes (42) are arranged in an array in the same detection plane. In this way, the four atomic magnetic sensor probes for collecting environmental noise and its gradient are arranged in different directions in space, and the coordinates of each probe are known. The measured value of probe B minus the measured value of probe A divided by the distance between AB can be obtained to obtain the gradient of the magnetic field in the z direction. Similarly, the measured value of probe C minus the measured value of probe A divided by the distance between AC can be obtained to obtain the gradient of the magnetic field in the y direction. Similarly, the measured value of probe D minus the measured value of probe A divided by the distance between AD can be obtained to obtain the gradient of the magnetic field in the x direction. Based on the z-projected distance, x-projected distance, and y-projected distance of each second magnetic sensor probe from A, combined with the calculated gradients in the x-, y-, and z-directions, the background magnetic field at each probe position below can be calculated. Subtracting the calculated background magnetic field from the measured value is equivalent to suppressing the background noise at the measurement position, thereby improving the quality of the measured signal.

[0025] A preferred solution is that a plurality of second magnetic sensor probes are arranged into an array according to the shape and area of ​​the measured target, covering the entire measured area.

[0026] Preferably, the magnetic shielding device (5) is made of a material with high magnetic permeability and has an internal space capable of accommodating the probe holder and the human body to be measured. The magnetic shielding device (5) is a cylindrical magnetic shielding tube with one end closed and the other end open.

[0027] Preferably, the supporting and positioning mechanical device comprises a base (1), an inspection bed assembly (2) and a probe support (4); the inspection bed assembly (2) is mounted on the base and can move linearly on the base (1) along the X direction; the probe support (4) is mounted on the inspection bed assembly (2) and can move linearly on the inspection bed assembly (2) along the X direction; a part of the base (1) is fixed inside the magnetic shielding device (5), and another part of the base (1) is fixed outside the magnetic shielding device (5). Preferably, the inspection bed assembly is driven to move by a motor, and the motor is located outside the magnetic shielding device.

[0028] Preferably, the relative position between the examination bed assembly (2) and the base (1) is fixed by a first locking device.

[0029] Preferably, the examination bed assembly (2) comprises an upper bed board and a lower bed board, wherein the upper bed board can move linearly along the X direction on the lower bed board; the upper bed board and the lower bed board are fixed relative to each other by a positioning device; the probe bracket (4) is installed on the lower bed board of the examination bed assembly (2), and the probe bracket (4) and the examination bed assembly (2) are fixed relative to each other by a second locking device. Preferably, the probe bracket can move linearly along the Z direction to adjust the distance between the sensor probe and the measured body.

[0030] Preferably, the probe support (4) is provided with a laser emitting device, which can emit a visible laser beam downward in the Z direction for indicating the measurement position. In this way, the visible laser beam is used to indicate the measurement area, and assists in adjusting the position between the sensor probe and the measured body in the X direction and the Y direction. Preferably, the shape of the laser beam is point-shaped or line-shaped in the XY plane; the number of beams is 1 to 4; and the laser color is red or green.

[0031] The system control and data processing unit includes several modules including sensor control, system control, data acquisition, data processing and data communication, as well as auxiliary equipment such as power supply, and an optional ECG signal module. Among them, the sensor control, system control, data acquisition and data processing parts also include programs to realize their respective functions.

[0032] The system operation unit is composed of intelligent electronic devices such as computers or tablet computers and programs, and is connected to the system control and information processing unit through a high-speed data channel. It is further preferred to support multiple system operation units to operate and use the system simultaneously.

[0033] The signal of the ECG module is connected to the data acquisition unit of the system, and the obtained data is used to assist the system signal processing to obtain better magnetic heart signal processing results.

[0034] A biomagnetic quantum detection method adopts the biomagnetic quantum detection system as described above to implement biomagnetic field measurement.

[0035] A probe holder for a biomagnetic quantum detection system, comprising at least three first magnetic sensor probes (41) for collecting background noise and background magnetic field gradient information and a plurality of second magnetic sensor probes (42) for receiving biomagnetic fields, wherein the first magnetic sensor probes (41) and the second magnetic sensor probes (42) are both fixed on the probe holder (4), and the second magnetic sensor probes (42) are located below the first magnetic sensor probes (41).

[0036] The present invention adopts the above technical solution, collects the background magnetic noise and its gradient, calculates the common mode magnetic noise of each measurement position in space, suppresses the data noise of the measurement position by calculation, improves the signal quality of the measurement position, reduces the measurement error, and further improves the accuracy and sensitivity of biomagnetic detection. The system is used to complete the biomagnetic data collection of human organs and local tissues at dense dot arrays under normal temperature conditions, and diagnoses abnormal changes in related organs and tissues. A special application is the detection and feature extraction of the human heart magnetic field for the diagnosis of heart disease. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The drawings in the specification, which constitute a part of the present application, are used to provide a further understanding of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute a limitation on the present application.

[0038] Figure 1 It is a structural schematic diagram of the system of the present invention;

[0039] Figure 2 This is a schematic diagram of the position change of the examination bed moving along the x direction in the system of the present invention;

[0040] Figure 3 This is a schematic diagram of the first arrangement of magnetic sensor probes;

[0041] Figure 4 This is a schematic diagram of the second arrangement of magnetic sensor probes;

[0042] Figure 5 This is a schematic diagram of measurement positioning of the first arrangement of magnetic sensor probes;

[0043] Figure 6 It is a schematic diagram of the system control and data processing flow of the present invention;

[0044] Figure 7 Schematic diagram of the biomagnetic detection grid points of the human heart.

[0045] Among them, 1. base; 2. examination bed assembly; 21. lower bed; 3. human body to be measured; 4. probe bracket; 41. first magnetic sensor probe; 42. second magnetic sensor probe; 5. magnetic shielding device; 6. sensor cable; 7. system cabinet; 8. data cable; 9. system operation unit. DETAILED DESCRIPTION

[0046] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0047] It should be noted that the following detailed descriptions are illustrative and are intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present application belongs.

[0048] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention.

[0049] In the description of the present invention, unless the context clearly indicates otherwise, the singular form is intended to include the plural form. In addition, it should be understood that when the terms "include" and / or "comprises" are used in this specification, they indicate the presence of features, steps, operations, devices, components and / or their combinations.

[0050] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0051] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, "plurality" means two or more, unless otherwise clearly specified.

[0052] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0053] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0054] Embodiment 1:

[0055] like Figure 1 The biological magnetic quantum detection system comprises:

[0056] An atomic magnetic sensor group for measuring biomagnetic field, composed of a plurality of atomic magnetic sensors, wherein the atomic magnetic sensor includes a sensor probe and a sensor controller;

[0057] A magnetic shielding device 5 for shielding external magnetic fields and electromagnetic noise;

[0058] A supporting and positioning mechanical device, comprising a base 1, an examination bed assembly 2 for fixing a human body to be tested, and a probe bracket 4 for fixing a sensor probe;

[0059] System control and data processing unit;

[0060] and a system operating unit;

[0061] Wherein, the sensor probe comprises:

[0062] At least three first magnetic sensor probes 41 for collecting background noise and background magnetic field gradient information,

[0063] and a plurality of second magnetic sensor probes 42 for receiving biological magnetic fields;

[0064] The first magnetic sensor probe 41 and the second magnetic sensor probe 42 are both fixed on the probe bracket 4 , and the second magnetic sensor probe 42 is located below the first magnetic sensor probe 41 .

[0065] In this embodiment, the probe holder 4 is arranged in the magnetic shielding device 5, and the sensor probe mounted on the probe holder 4 is connected to the sensor controller mounted outside the magnetic shielding device 5 via the sensor cable 6. In this way, the sensor probe is close to the human organ or tissue to receive the human biomagnetic field, and the sensor controller is at a suitable distance from the sensor probe to reduce the interference to the measured biomagnetic field.

[0066] In one embodiment, three first magnetic sensor probes 41 are arranged on the probe bracket 4, namely probe A, probe B and probe C. Probe A and probe B are arranged up and down along the Z direction, probe A and probe C are arranged front and back along the Y direction, and multiple second magnetic sensor probes 42 are located below the first magnetic sensor probe 41 and arranged in a row front and back along the Y direction. The three first magnetic sensor probes 41 and the multiple second magnetic sensor probes 42 are in the same YZ plane. In this way, the coordinates of each probe are known; the measured value of probe B minus the measured value of probe A divided by the distance between AB can be obtained to obtain the gradient of the magnetic field in the z direction. Similarly, the measured value of probe C minus the measured value of probe A divided by the distance between AC can be obtained to obtain the gradient of the magnetic field in the y direction; then, according to the z projection distance of the multiple probes below from A, and the y projection distance, combined with the calculated gradients in the z direction and y direction, the background magnetic field at the position of each second magnetic sensor probe below can be calculated; subtracting the calculated background magnetic field from the measured value is equivalent to suppressing the background noise at the measurement position, thereby improving the quality of the signal to be measured. The preferred solution is that multiple second magnetic sensor probes are evenly arranged in a row along the Y direction, and the length of the probe arrangement covers the Y-direction dimension of the area to be measured. The preferred solution for detecting the cardiomagnetic signal is to configure 6 to 12 atomic magnetic sensors, with a distance of 30 to 50 mm between the probes.

[0067] In another embodiment, four first magnetic sensor probes 41 are arranged on the probe bracket 4, namely probe A, probe B, probe C and probe D, probe A and probe B are arranged up and down along the Z direction, probe A and probe C are arranged front and back along the Y direction, probe A and probe D are arranged left and right along the X direction, and at least four second magnetic sensor probes 42 are arranged in an array in the same detection plane. In this way, the four atomic magnetic sensor probes used to collect environmental noise and its gradient are arranged in different directions in space, and the coordinates of each probe are known. The measured value of probe B minus the measured value of probe A divided by the distance between AB can obtain the gradient of the magnetic field in the z direction. Similarly, the measured value of probe C minus the measured value of probe A divided by the distance between AC can obtain the gradient of the magnetic field in the y direction. Similarly, the measured value of probe D minus the measured value of probe A divided by the distance between AD can obtain the gradient of the magnetic field in the x direction. Then, according to the z projection distance, x and y projection distance of each second magnetic sensor probe from A, combined with the calculated gradients in the x, y and z directions, the background magnetic field at each probe position below can be calculated. Subtracting the calculated background magnetic field from the measured value is equivalent to suppressing the background noise at the measurement position, thereby improving the quality of the measured signal. The preferred solution is to arrange multiple second magnetic sensor probes into an array according to the shape and area of ​​the measured target, covering the entire measured area.

[0068] The above two implementations can be used not only for biomagnetic field measurement, but also for other weak magnetic field measurement fields. Therefore, this embodiment also discloses:

[0069] A magnetic field detection method, comprising a plurality of magnetic sensors for measuring a magnetic field, wherein the magnetic sensors comprise a sensor probe and a sensor controller; the sensor probe comprises three first magnetic sensor probes 41 for collecting background magnetic field and gradient information thereof and a plurality of second magnetic sensor probes 42 for collecting signals of a magnetic field to be measured, wherein the plurality of second magnetic sensor probes 42 are arranged close to a measured area and distributed in the same detection plane, and the first magnetic sensor probe 41 is arranged away from the measured area; the three first magnetic sensor probes 41 are probe A, probe B and probe C, respectively, wherein probe A and probe B are arranged up and down along the Z direction, and probe A and probe C are arranged front and back along the Y direction, wherein the detection plane is an XY plane, and the plurality of second magnetic sensor probes are arranged in a row along the Y direction, wherein each of the first magnetic sensor probes 41 and the second magnetic sensor probes 42 are in the same YZ plane; the detection comprises the following steps: measuring probe B The measured value of probe A is subtracted from the measured value of probe C and divided by the distance between the two to obtain the gradient of the background magnetic field in the Z direction; the measured value of probe C is subtracted from the measured value of probe A and divided by the distance between the two to obtain the gradient of the background magnetic field in the Y direction; the background magnetic field at the position of each second magnetic sensor probe is calculated according to the Z projection distance and Y projection distance of each second magnetic sensor probe 42 from probe A, combined with the calculated gradients of the background magnetic field in the Z direction and the Y direction; the background magnetic field is subtracted from the measured value obtained from each second magnetic sensor probe to obtain the magnetic field signal of the measured magnetic field at the position of each second magnetic sensor probe; all measurement data of the measured area are obtained by synchronously moving the first magnetic sensor probe 41 and the second magnetic sensor probe 42 to traverse each measurement point in the measured area.

[0070] In this embodiment, 6 to 12 second magnetic sensor probes 42 are further included, and the distance between two adjacent second magnetic sensor probes 42 is 30 to 50 mm. The length of the plurality of second magnetic sensor probes 42 is arranged to cover the Y-direction dimension of the area to be measured. The first magnetic sensor probe 41 and the second magnetic sensor probe 42 move synchronously along the X-direction.

[0071] A magnetic field detection method includes a plurality of magnetic sensors for measuring a magnetic field, wherein the magnetic sensors include a sensor probe and a sensor controller; the sensor probe includes four first magnetic sensor probes 41 for collecting background magnetic field and gradient information thereof and a plurality of second magnetic sensor probes 42 for collecting measured magnetic field signals, wherein the plurality of second magnetic sensor probes 42 are arranged close to a measured area, and the first magnetic sensor probes 41 are arranged away from the measured area; the four first magnetic sensor probes 41 are probe A, probe B, probe C and probe D, respectively, wherein probe A and probe B are arranged vertically along the Z direction, and probe A and probe C are arranged vertically along the Y direction. The probes A and D are arranged front to back in the X direction, and the probes A and D are arranged left to right in the X direction. A plurality of second magnetic sensor probes 42 are distributed in an array in the same detection plane, and the detection plane is the XY plane. The detection includes the following steps: the measured value of probe B is subtracted from the measured value of probe A and divided by the distance between the two to obtain the gradient of the background magnetic field in the Z direction, the measured value of probe C is subtracted from the measured value of probe A and divided by the distance between the two to obtain the gradient of the background magnetic field in the Y direction, and the measured value of probe D is subtracted from the measured value of probe A and divided by the distance between the two to obtain the gradient of the background magnetic field in the X direction; the background magnetic field at the position of each second magnetic sensor probe is calculated according to the Z projection distance, X projection distance and Y projection distance of each second magnetic sensor probe 42 from probe A, combined with the calculated gradients of the background magnetic field in the Z direction, X direction and Y direction; the background magnetic field is subtracted from the measured value obtained from each second magnetic sensor probe to obtain the magnetic field signal of the measured magnetic field at the position of each second magnetic sensor probe.

[0072] In this embodiment, preferably, a plurality of second magnetic sensor probes are arranged into an array capable of covering the entire measured area. The second magnetic sensor probe (42) can also be moved to traverse each measuring point in the measured area to obtain all measurement data of the measured area.

[0073] A magnetic field detection system adopts the magnetic field detection method as described above.

[0074] In this embodiment, the magnetic shielding device 5 is made of a high magnetic permeability material and has an internal space capable of accommodating the probe bracket and the human body to be measured. The magnetic shielding device 5 is a cylindrical magnetic shielding tube with one end closed and the other end open.

[0075] In this embodiment, the supporting and positioning mechanical device includes a base 1, an inspection bed assembly 2 and a probe bracket 4. The inspection bed assembly 2 is mounted on the base and can move linearly on the base 1 along the X direction; the probe bracket 4 is mounted on the inspection bed assembly 2 and can move linearly on the inspection bed assembly 2 along the X direction; a part of the base 1 is fixed inside the magnetic shielding device 5, and another part of the base 1 is fixed outside the magnetic shielding device 5. Preferably, the inspection bed assembly is driven to move by a motor, and the motor is located outside the magnetic shielding device. Preferably, the relative position between the inspection bed assembly 2 and the base 1 is fixed by a first locking device.

[0076] In this embodiment, the inspection bed assembly 2 includes an upper bed board and a lower bed board, wherein the upper bed board can move linearly along the X direction on the lower bed board; the upper bed board and the lower bed board are fixed relative to each other by a positioning device; the probe bracket 4 is installed on the lower bed board of the inspection bed assembly 2, and the probe bracket 4 and the inspection bed assembly 2 are fixed relative to each other by a second locking device. Preferably, the probe bracket can move linearly along the Z direction to adjust the distance between the sensor probe and the human body being measured.

[0077] In this embodiment, a laser emitting device is provided on the probe holder 4, and the laser emitting device can emit a visible laser beam downward in the Z direction for indicating the measurement position. In this way, the visible laser beam is used to indicate the measurement area, and assists in adjusting the position between the sensor probe and the measured body in the X direction and the Y direction. Preferably, the shape of the laser beam is point-shaped or line-shaped in the XY plane; the number of beams is 1 to 4; and the laser color is red or green.

[0078] The system control and data processing unit includes several modules including sensor control, system control, data acquisition, data processing and data communication, as well as auxiliary equipment such as power supply, and an optional ECG signal module. Among them, the sensor control, system control, data acquisition and data processing parts also include programs to realize their respective functions. The system operation unit is composed of intelligent electronic devices such as computers or tablet computers and programs, and is connected to the system control and information processing unit through a high-speed data channel. It is further preferred to support multiple system operation units to operate and use the system at the same time. The signal of the ECG module is connected to the data acquisition unit of the system, and the obtained data is used to assist the system signal processing to obtain better cardiomagnetic signal processing results. These are all prior art.

[0079] The various parts of the system are further elaborated as follows:

[0080] 1. Atomic magnetic sensor group

[0081] The atomic magnetic sensor detects the change of atomic energy level under the action of magnetic field based on the interaction between light and atoms, so as to achieve accurate magnetic field measurement. It includes laser light source, optical prism and lens, atomic gas chamber, and photoelectric conversion module. The laser light source uses a miniaturized laser chip, whose wavelength corresponds to the selected atom. The optical prism and lens shape the laser and control its polarization state, and then inject it into the atomic gas chamber. The atomic gas chamber is a highly transparent sealed glass container with a sufficient amount of a certain alkali metal. In some examples, rubidium atoms are placed in the atomic gas chamber; in other examples, cesium atoms are placed in the atomic gas chamber. Under low pressure and appropriate heating conditions, a certain concentration of alkali metal atomic vapor is formed in the atomic gas chamber. In some examples, appropriate nitrogen or inert gas is added to the atomic gas chamber to limit the movement of gaseous alkali metals to obtain better measurement results. According to the needs of actual engineering, in some examples, the atomic gas chamber adopts a square (rectangular) cube shape; in other examples, the atomic gas chamber adopts a cylindrical or spherical shape. The size of the atomic gas chamber is usually less than 30 mm.

[0082] By setting the appropriate temperature and magnetic field environment for the atomic gas chamber and providing a specific pump laser, the alkali metal vapor in the atomic gas chamber is polarized and enters a certain quantum state, becoming a working medium that can sensitively sense the magnetic field strength. The detection laser passes through the atomic gas chamber and acts on the polarized alkali metal atoms, thereby carrying the quantum state information of the alkali metal atoms. The outgoing light is converted into an electrical signal through the photoelectric conversion module and transmitted to the control unit through a cable to realize the analysis and extraction of the magnetic field. According to different implementation methods, atomic magnetic measurement technology is divided into Mx optical pumping, Mz optical pumping, spin-free relaxation exchange (SERF) and other sub-technologies.

[0083] In different implementation schemes, the pump laser and the detection laser may be two different laser beams or the same laser beam.

[0084] One implementation scheme is that the atomic magnetic sensor includes an atomic magnetic sensor probe, an atomic magnetic sensor controller and a sensor cable. Among them, the atomic gas chamber is installed in the atomic magnetic sensor probe to detect the magnetic field at its own location. The sensor probe is also equipped with a laser generator, a magnetic field generator and a temperature control device, as well as a detection laser detection device. The sensor controller provides the control signals required by these working devices of the sensor probe, and receives and processes the output signals of the laser detection device. These input and output signals are transmitted through the sensor cable.

[0085] The atomic magnetic sensor controller further provides an external interface for receiving instructions from external devices and providing detection signals or data to the external devices.

[0086] According to the sensor installation density requirements and the equipment installation space limitations, there are certain restrictions on the size of the sensor probe. In the present invention, the projection of the sensor probe on the measurement plane is required to be less than 30mm*30mm and the length is less than 100mm. The preferred embodiment is that the sensor probe is made into a 20mm*20mm*60mm cuboid, in which the 20mm*20mm surface faces the object to be measured.

[0087] In order to detect the spatial distribution of the human body magnetic field, a plurality of the above-mentioned atomic magnetic sensors are arranged in the system. The human body magnetic field is very weak. Taking the heart magnetic field as an example, its peak-to-peak value is usually less than 100pT, and the earth's magnetic field is usually 50000000pT. Therefore, the drift and change of the environmental magnetic field during measurement will seriously affect the measured results. It is worth noting that the environmental magnetic field is not uniform, but there is a magnetic field gradient. Therefore, at different measurement positions, the impact of the change of the environmental magnetic field is also different, which introduces measurement noise. The noise caused by this change in the environmental magnetic field may even be much greater than the biomagnetic field signal to be measured, so that the measured biomagnetic signal has a low signal-to-noise ratio and is even submerged in the background noise. The introduction of a magnetic shielding device, such as the magnetic shielding barrel described below, will reduce the environmental noise and improve this problem to a certain extent, but it cannot completely solve it. In order to further improve the measurement level, the present invention divides the above-mentioned atomic magnetic sensor into two groups, one group is a first magnetic sensor probe group 41 for collecting the background magnetic noise and its gradient information of the measurement environment, and the other group is a second magnetic sensor probe group 42 for collecting biomagnetic signals.

[0088] like Figure 3 A preferred arrangement shown in FIG. 4 , wherein the first magnetic sensor probe 41 used to collect background noise and its gradient includes three probes ABC, probes A and B are arranged up and down along the Z direction, probes A and C are arranged front and back along the Y direction, and the second magnetic sensor probe 42 used to collect biomagnetic signals is located below the first magnetic sensor probe 41 and arranged in a row front and back along the Y direction, and the three probes ABC and the seven probes below are in the same YZ plane. The coordinates of each probe are known. The measured value of probe B minus the measured value of probe A divided by the distance between AB can be used to obtain the gradient of the magnetic field in the z direction. Similarly, the measured value of probe C minus the measured value of probe A divided by the distance between AC can be used to obtain the gradient of the magnetic field in the y direction. Then, according to the z projection distance of the seven probes below from A, and the y projection distance, combined with the calculated gradients in the z direction and y direction, the background magnetic field at the positions of the seven probes below can be calculated. Subtracting the calculated background magnetic field from the measured value is equivalent to suppressing the background noise at the measurement position, thereby improving the quality of the signal to be measured. In this way, the magnetic field gradients in two directions can be calculated, and the magnetic field common mode noise at all positions in the plane formed by these two directions can be deduced.

[0089] The above arrangement only considers the measurement in the yz plane. Similarly, another preferred solution is to add an atomic magnetic sensor probe D. Probe D and probe A are arranged left and right along the X direction. Then, the magnetic field gradient in the x direction can be calculated, and then the magnetic field noise at all measurement positions below can be calculated, such as Figure 4 shown.

[0090] The specific mathematical calculation process is as follows.

[0091] Assume that A is at (0,0,0) and its measurement value is V0. B is at (0,0,lz) and its measurement value is Vz. C is at (0,ly,0) and its measurement value is Vy. D is at (lx,0,0) and its measurement value is Vx.

[0092] Then, the common-mode magnetic field noise V at any position (x, y, z) in space is:

[0093]

[0094] The collected magnetic field signal is subtracted from the calculated common mode noise and then used for subsequent data processing.

[0095] In this way, the magnetic field gradient in the y direction can be calculated from the detection data at positions A and B. Similarly, the magnetic field gradient in the Z direction can be calculated from the detection data at positions A and C. Similarly, the magnetic field gradient in the X direction can be calculated from positions A and B. The detection data at position A can be regarded as environmental noise. Based on the three-axis gradient information of the background magnetic field and the magnetic field noise at a point, the common-mode magnetic field noise at any position in space can be calculated for common-mode noise suppression at the measurement position.

[0096] 2. Magnetic shielding device

[0097] The biomagnetic signal of the human body is extremely weak. If it is not controlled, the earth's magnetic field and environmental electromagnetic waves will have a serious impact on the measurement. The magnetic shielding device shields the external magnetic field and electromagnetic noise to prevent the internal device from external interference. For some atomic magnetic technologies, such as SERF, the sensor probe needs to work in an environment close to zero magnetic field.

[0098] The magnetic shielding device is made of high magnetic permeability alloy material. Commonly used high magnetic permeability materials are Permalloy and silicon steel. The magnetic shielding device uses a certain thickness of the high magnetic permeability alloy plate to make a closed or semi-closed cavity. The size of the cavity must at least be able to accommodate the sensor probe and its accessories, and part or all of the human body being measured. The magnetic field strength of the entire or local area in the cavity is less than a specified value, such as 50nT (the earth's magnetic field is 45000nT to 60000nT). The size of this area must at least cover all the measurement points.

[0099] The thickness of the high magnetic permeability alloy plate is usually in the range of 0.1 mm to 10 mm. Using multiple layers of alloy plates to make a magnetic shielding device can achieve a better shielding effect and achieve the required shielding performance. In this embodiment, 3 to 5 layers of Permalloy are used to make a magnetic shielding device; in other embodiments, 8 to 10 layers of silicon steel alloy can be used to make a magnetic shielding device.

[0100] The magnetic shielding device can be a rectangular (square) magnetic shielding room, or a cylindrical magnetic shielding tube. A fully enclosed magnetic shielding device can achieve better shielding performance. In this case, the shielding room or shielding tube needs to have an openable door or cover device to facilitate the entry or removal of the sensor probe and the target to be measured.

[0101] In this embodiment, a semi-enclosed magnetic shielding cylinder device is preferably used, such as Figure 1 As shown. The main body of the magnetic shielding tube is made of four layers of Permalloy, with an inner diameter of Φ3: 850mm, an outer diameter of Φ2: 1000, and a length of L: 2m. A 10mm thick aluminum alloy cylinder shell is added to the outside of the main body of the magnetic shielding tube to support and protect the main body of the magnetic shielding tube. Four Permalloy covers are used at one end of the shielding tube to cover the four-layer Permalloy cylinder in turn, and an aluminum alloy cover is used to cover the aluminum alloy shell. The other end of the shielding tube is open to facilitate the entry and exit of the sensor probe device and the person being measured.

[0102] 3. Support and positioning mechanical device

[0103] The supporting and positioning mechanical device includes a base 1, an examination bed assembly 2 and a probe bracket 4. Figure 1 The supporting and positioning mechanical device is used to fix the atomic magnetic sensor probe and the measured human body, and can adjust the relative position between the probe and the measured human body part, so that the probe is positioned at a suitable position for measurement.

[0104] The base is divided into two parts, one part is fixed inside the magnetic shielding device, and the other part is fixed to the ground outside the shielding tube. The two parts of the base are closely connected, and the upper surface forms a solid platform with the same plane.

[0105] The examination bed assembly consists of two layers of bed boards, upper and lower. Slide wheels and slideways are installed between the upper and lower bed boards, so that the upper bed board can move linearly along the X direction on the lower bed board. The pulley can be installed on the upper bed board or the lower bed board. The person being tested lies flat on the upper bed board and moves with the upper bed board, such as Figure 2 shown.

[0106] In some embodiments, the area to be measured is larger than the configured sensor coverage area, and the upper bed board needs to be moved to change the relative position of the human body and the sensor probe. Figure 5As shown, R marking lines are arranged on the lower bed board 21, marked as 1, 2, ..., R, and the upper bed board is moved so that its outer edge is aligned with a marking line to locate a sub-position of a measurement. The distance between the marking lines is the distance of the measurement sub-position, and the specific value is determined according to the spatial density requirements of the measurement. Preferably, the marking lines are evenly distributed, with a distance of 30mm to 50mm.

[0107] Furthermore, a locking device is installed between the upper bed board and the lower bed board. When the locking device is activated, the position between the upper bed board and the lower bed board can be fixed. During the detection process, locking the positions of the two can make the measurement position accurate; in the detection preparation stage, locking the positions of the two can facilitate the person being tested to get on and off the inspection bed.

[0108] The probe holder 4 is mounted on the lower bed board 21 of the examination bed assembly 2 and can be moved in the X direction to adjust the relative position between the probe holder and the examination bed assembly. In the preparation stage of the test, after the person to be tested lies on the upper bed board, the position of the probe holder is adjusted to the target position of the person to be tested, and then the position between the probe holder and the lower bed board is locked.

[0109] The examination bed assembly 2 is mounted on the base 1. There are sliding wheels and slideways between the examination bed assembly and the base, so that the examination bed assembly can move linearly along the X direction on the base. There is a locking device between the examination bed assembly and the base to fix the relative position between the two when adjusted to a suitable position.

[0110] The motion mechanism in the supporting positioning mechanical device includes the sensor probe bracket and the examination bed assembly, the examination bed assembly and the base, and the space between the two bed boards of the examination bed assembly. These motion mechanisms can be manually pushed and moved, or driven by a motor, or a combination of the two. In the specific implementation example, several moving methods can be combined as needed.

[0111] The support positioning mechanism sets two optimal positions, namely the initial position and the measurement position. In the initial position, the two bed boards of the inspection bed assembly are at the farthest position outside the shielding tube, and the sensor probe bracket is at the end close to the shielding tube. Figure 2 As shown in B; in the measurement state, the two layers of the bed board of the inspection bed assembly are at the innermost position in the shielding tube, and the sensor probe bracket is adjusted to the appropriate measurement position, such as Figure 2 As shown in A.

[0112] During the measurement preparation and end stages, the support and positioning mechanical device is adjusted to the initial state to facilitate the person being measured to get on and off the examination bed.

[0113] During the measurement process, the support and positioning mechanism is in the measurement position, and the sensor probe is locked with the lower bed board of the examination bed assembly. If necessary, the upper bed board of the examination bed assembly is moved, and the measured body moves with the upper bed board to change the measurement point. This design of the support and positioning mechanism allows the sensor to remain stationary throughout the measurement process, which helps to quickly and accurately measure.

[0114] In a preferred embodiment, a laser beam can also be used to assist in adjusting the sensor probe. A laser emitting device is installed on the probe holder to emit a visible laser beam downward in the Z direction to indicate the measurement area, so that the system operator can adjust the position between the sensor probe and the measured body in the X and Y directions to make the measurement position accurate. The laser beam can indicate the human heart biomagnetic detection area with a rectangular area, a cross line or a single point.

[0115] More preferably, the shape of the laser beam is point-shaped or line-shaped in the XY plane, the number of beams is 1 to 4, and the color of the laser is red or green.

[0116] In this embodiment, a rectangular area is preferably used to indicate the detection position of the sensor probe. The rectangular area is surrounded by four planar linear light beams. Specifically, the laser emitting device emits four planar linear light beams downward along the Z direction, forming a rectangle on the surface of the human body, and the rectangular area indicates the effective position detected by the sensor probe. Taking the heart biomagnetic detection as an example, the operator can adjust the relative position of the probe holder and the human body according to the indication of this rectangular frame, so that the human heart magnetic field measurement area is aligned with the rectangular frame.

[0117] In other embodiments, two planar linear laser beams may be used to form a cross line to indicate the center position detected by the sensor probe.

[0118] In other embodiments, a planar point laser beam may be used to form a light spot to indicate the center position detected by the sensor probe.

[0119] 3.1 Probe Arrangement and Dense Array Acquisition Method

[0120] Biomagnetic detection applications usually require high-density measurement and collection in one area. Taking the human heart biomagnetic detection application as an example, a plane area above the chest close to the human body (about 1 cm away) with the human heart as the center is preferably used as the measurement area. In this area, a uniform grid of N columns and R rows is determined, and magnetic field data is measured for a period of time (for example, 30 seconds) at each grid point. Figure 7As shown in the figure, a small square is the measurement position of a sensor probe, and the center of the square corresponds to the detection center of the sensor probe; the area size is preferably 20 to 25 cm in both the X and Y directions; the measurement grid point density is preferably 30 to 50 mm from the center position of adjacent measurement points;

[0121] Taking a grid point of 7 columns*7 rows as an example, the preferred grid point size is 3.5cm*3.5cm, and the coverage range of the measurement is calculated to be an area of ​​24.5cm*24.5cm.

[0122] In this embodiment, Figure 4 As shown, a sensor probe array of 7 columns*7 rows is preferably configured, with a total of 49 atomic magnetic sensors.

[0123] In other implementations, if the number of sensors is less than the number of grid points to be measured, multiple acquisitions are required to cover the area to be measured.

[0124] For example, 7 atomic magnetic sensors are configured, and the probes of the 7 sensors are arranged in a row along the Y direction, and the center distance between adjacent probes is 3.5 cm. Figure 3 The testing process of the cardiac biomagnetic detection system of this configuration is described.

[0125] Before the measurement begins, the atomic magnetic sensor probe is adjusted to the measurement position ① and locked, and then data collection begins to obtain data for a row of 7 measurement points at the measurement position ①. Then the upper bed board of the examination bed assembly is moved along the X direction, that is, the human body position is moved, or the detection plane position is detected, to the measurement position ②, and the 7 measurement points in the ②th row are collected; the above process is repeated until all 7 rows of measurement point data are collected, and all measurement data of the 7*7 grid is obtained. The center distance between adjacent measurement positions is 3.5cm. It should be noted that the measurement can start from any position of the measurement positions ① to ⑦; the order of measurement can also be arbitrary, as long as all 7 positions are finally measured.

[0126] 4. System control and data processing unit

[0127] The system control and data processing unit is an electronic information system composed of electronic components and programs, including sensor control, system control, data acquisition, data processing and data communication modules, as well as auxiliary equipment such as power supply, and an optional ECG signal module. Among them, the sensor control, system control, data acquisition, data processing and other modules also include programs to automatically manage and control the electronic and mechanical components inside the system, as well as process the business data in the system, all of which are existing technologies.

[0128] The working principle of the system control and data processing unit mainly includes the transfer relationship of business data and the role relationship of control information, such as Figure 6As shown, the solid line represents the business data flow and the dotted line represents the control information flow.

[0129] The system business data flow describes the processing process of the magnetic field strength information of the measured target after entering the system. The sensor controller receives the abstract information signal of the magnetic field strength from the sensor probe, and obtains the specific electrical signal representing the magnitude of the magnetic field after analysis and processing. The data acquisition module converts it into digital data, and then sends it to the data processing module through the data communication module for digital signal processing, magnetic image analysis, clinical parameter analysis, data storage, etc. The data communication module also provides an external interface to provide data services to external devices.

[0130] The system control information flow is centered on the system control module. The system control module manages all modules in the system, including opening and closing, operating status monitoring, and parameter settings. At the same time, the system control module also controls the operation of the system business data flow, including configuring business and managing access rights.

[0131] Figure 1 The system operation unit in the system can obtain business data from the data processing unit by requesting services from the system control module.

[0132] 4.1 Data Processing

[0133] Data processing mainly includes two steps: digital signal processing and biomagnetic model analysis.

[0134] Digital signal processing is to optimize the signal field of the collected sensor signals (including atomic magnetic sensor signals and optional ECG signals), remove noise and unnecessary information, and leave the required high signal-to-noise ratio information. The magnetic field waveform data of each grid point is filtered, synchronized, averaged, etc. in turn to obtain clear waveform data of a heartbeat cycle. In some embodiments, the biomagnetic detection system is equipped with an ECG module for signal synchronization to obtain better processing effects. These are all prior art.

[0135] In signal processing, some noise components, especially low-frequency noise, are difficult to process. In this embodiment, N+M (N≥4, M≥3) sensors are configured, wherein the probes of N sensors are close to the human body to detect the biomagnetic signals of the human organs or tissues under test, and the probes of M sensors are installed at a suitable position away from the human organs or tissues under test, and are used to collect the background magnetic field inside the shielding tube, assist in signal estimation and processing, and obtain better processing results. Specifically, it is assumed that the magnetic field data in the Z direction obtained by the N sensors used to measure the biomagnetic signals are: B Z1 , B Z2 , …, B ZN The magnetic field data in the Z direction obtained by the M sensors for measuring biomagnetic signals are: DZ1 , D Z2 , …, D ZM ; Determination coefficient matrix {c nm}, (n=1,2,…N;m=1,2,…,M), then

[0136]

[0137] B' zn (n=1, 2, ..., N) is the estimated signal with some background noise components removed. The coefficient matrix {c nm}The results are obtained by testing and analyzing zero input and some special training signal input. Actual tests show that using three sensors to collect background noise can achieve good processing results.

[0138] After completing the digital signal processing step, the biomagnetic signal is further analyzed by the biomagnetic model to extract the biomagnetic characteristic value and make a disease diagnosis. This process needs to be combined with clinical experiments to determine the effective characteristic value through a large amount of clinical data.

[0139] The research on cardiac biomagnetism has a history of more than 20 years, and magnetocardiogram products are currently in clinical application. A preferred approach is to take the cardiac biomagnetic data at certain special time points in a heart cycle, improve the spatial high resolution through interpolation, and draw the magnetic field map with contour lines; at the same time, the pseudo-current map is calculated from the magnetic field data analysis. These special time points are usually taken as the R peak, T peak, the beginning of the ST phase, and the stages before and after the T peak. Based on their magnetic field maps and pseudo-current maps, certain heart diseases can be diagnosed. At present, myocardial ischemia is a relatively mature clinical diagnosis application.

[0140] 5. System operation unit

[0141] The system operation unit is composed of intelligent electronic devices such as computers or tablet computers and programs. The equipment of the system operation unit is connected to the system control and information processing unit through a high-speed data channel. These are all existing technologies.

[0142] The system operation unit provides users with operation and maintenance equipment. For medical personnel, the system operation unit provides functions such as logging into the system, performing biomagnetic detection operations, and viewing patient historical data; for maintenance technicians, the system operation unit provides functions such as system configuration and system diagnosis. The system operation unit preferably provides a graphical interface for user convenience and supports multi-user operation, that is, multiple system operation units operate and use the system at the same time. In the event of an operation conflict, the system control and data processing unit will arbitrate based on the logged-in operator's authority and other conditions and select the appropriate operation.

[0143] The following is an explanation of the biomagnetic detection process based on different arrangements of sensor probes and specific examples:

[0144] In one embodiment, the first magnetic sensor probe and the second magnetic sensor probe are arranged in the same plane, and the human heart biomagnetic detection system includes:

[0145] 1) A set of atomic magnetic sensors, consisting of 10 atomic magnetic sensors. Figure 3 As shown, 7 probes of atomic magnetic sensors (second magnetic sensor probes 42) are evenly installed on the probe bracket in a straight line along the Y direction, and the center distance between adjacent probes is 3.5 cm, which is used to receive the biomagnetic field signal of the human body under test; the 8th to 10th atomic magnetic probes (first magnetic sensor probes 41) are installed on the upper part of the probe bracket, at least 10 cm away from the detection surface. The controller of the atomic magnetic sensor is installed in the system cabinet and connected to the sensor probe through a cable.

[0146] 2) A set of dual-lead ECG modules, the ECG module body is installed in the system cabinet, and the ECG electrodes are placed on the examination bed assembly of the supporting positioning device for standby use. The ECG electrodes are connected to the ECG module body through cables.

[0147] 3) A magnetic shielding tube, consisting of four layers of Permalloy cylinders and a 10mm thick aluminum alloy cylinder shell, with an inner diameter of Φ850mm, an outer diameter of Φ1000, and a length of 2m. One end of the shielding tube is closed with four Permalloy covers and one aluminum alloy cover, and the other end is open.

[0148] 4) A set of supporting and positioning mechanical devices, including a probe bracket, an examination bed assembly and a base, wherein a rectangular laser positioning device is arranged on the probe bracket; the examination bed assembly is provided with 7 measuring sub-position marks, and the distance between adjacent positions is 3.5 cm.

[0149] 5) A set of system control and data processing units, including a data sensor control module, a system control module, a data acquisition and processing module, a data communication module, and a power supply module; wherein the sensor control module, the system control module, and the data acquisition and processing module include respective control programs.

[0150] 6) A system operating unit consisting of a computer and the software running on the computer.

[0151] The probe adopts the above-mentioned planar arrangement of the human heart biomagnetic detection method, and the steps are as follows:

[0152] 1) Open the system control and data processing unit, open the system operation unit program and log in to the system;

[0153] 2) Move the examination bed assembly to the initial position outside the shielding tube and adjust the probe bracket to the initial position, such as Figure 2 B. Adjust the examination bed assembly to the measuring sub-position 4 (i.e., the middle measuring sub-position).

[0154] 3) The person being tested lies flat on the upper bed board, and the body position is adjusted so that the body is at the center of the upper bed board in the Y-axis direction, and the head is close to the end of the shielding tube in the X-axis direction of the upper bed board. Fix the electrodes of the dual-lead ECG module at the wrists and ankles of the person;

[0155] 4) Move the probe holder in the X direction to the position above the human heart; turn on the laser of the laser positioning device, and adjust the probe holder so that the rectangular area indicated by the laser covers the human heart magnetic field detection area (roughly put the heart in the center of the rectangular area, which requires personnel with certain medical knowledge to operate); adjust the probe holder in the Z direction to a suitable height position so that it is about 10mm away from the human body during the entire measurement process; then lock the X and Z positions of the probe holder;

[0156] 5) Push the double-layer examination bed, the probe bracket, and the person being measured together into the shielding tube along the X direction to the measurement position. Figure 2 As shown in A;

[0157] 6) Start the measurement program in the system operation unit program, initialize the sensor to the working state, and then collect data from the measurement sub-position 4;

[0158] 7) Move the upper bed board of the double-layer examination bed, and move the human body position to the 3rd, 2nd, 1st, 5th, 6th, 7th and other measurement sub-positions in turn to complete data collection of all sub-positions;

[0159] 8) The system control and data processing unit automatically processes and analyzes data in the background, and the time to complete data processing is no more than 10 seconds. The user can view the processing and analysis results in the system operation unit.

[0160] Another embodiment is that the first magnetic sensor probe and the second magnetic sensor probe are arranged in a three-dimensional space, and the human heart biomagnetic detection system includes:

[0161] 1) A set of atomic magnetic sensors, consisting of 53 atomic magnetic sensors. Figure 4As shown, 49 atomic magnetic sensor probes (second magnetic sensor probes 42) are evenly distributed in a 7*7 measurement point array on a probe holder, with a center distance of 3.5 cm between adjacent probes, for receiving the measured human heart magnetic biomagnetic field signal, and the detection plane formed by the second magnetic sensor probe covers the entire measured area of ​​the human heart; and 4 atomic magnetic sensor probes (first magnetic sensor probes 41) are installed on the upper part of the probe holder, at least 10 cm away from the detection surface. The controller of the atomic magnetic sensor is installed in the system cabinet and connected to the sensor probe through a sensor cable.

[0162] 2) A set of dual-lead ECG modules, the ECG module body is installed in the system cabinet, and the ECG electrodes are placed on the examination bed assembly of the supporting positioning device for standby use. The ECG electrodes are connected to the ECG module body through cables.

[0163] 3) A magnetic shielding tube, consisting of four layers of Permalloy cylinders and a 10mm thick aluminum alloy cylinder shell, with an inner diameter of Φ850mm, an outer diameter of Φ1000, and a length of 2m. One end of the shielding tube is closed with four Permalloy covers and one aluminum alloy cover, and the other end is open.

[0164] 4) A set of supporting and positioning mechanical devices, including a probe bracket, an examination bed assembly and a base, wherein a rectangular laser positioning device is arranged on the probe bracket.

[0165] 5) A set of system control and data processing units, including a data sensor control module, a system control module, a data acquisition and processing module, a data communication module, and a power supply module; wherein the sensor control module, the system control module, and the data acquisition and processing module include respective control programs.

[0166] 6) A system operating unit consisting of a computer and the software running on the computer.

[0167] The probe adopts the above-mentioned spatial arrangement of the human heart biomagnetic detection method, and the method steps are as follows:

[0168] 1) Open the system control and data processing unit, open the system operation unit program and log in to the system;

[0169] 2) Move the examination bed assembly to the initial position outside the shielding tube and adjust the probe bracket to the initial position, such as Figure 2 As shown in B.

[0170] 3) The person being tested lies flat on the upper bed board, and the body position is adjusted so that the body is at the center of the upper bed board in the Y-axis direction, and the head is close to the end of the shielding tube in the X-axis direction of the upper bed board. Fix the electrodes of the dual-lead ECG module at the wrists and ankles of the person;

[0171] 4) Move the probe holder in the X direction to the position above the human heart; turn on the laser of the laser positioning device, and adjust the probe holder so that the rectangular area indicated by the laser covers the human heart magnetic field detection area (roughly put the heart in the center of the rectangular area, which requires personnel with certain medical knowledge to operate); adjust the probe holder in the Z direction to a suitable height position so that it is about 10mm away from the human body during the entire measurement process; then lock the X and Z positions of the probe holder;

[0172] 5) Push the double-layer examination bed, the probe bracket, and the person being measured together into the shielding tube along the X direction to the measurement position. Figure 2 As shown in A;

[0173] 9) Start the measurement program in the system operation unit program, initialize the sensor to the working state, and then collect the data of each measurement point in the detection plane at one time;

[0174] 10) The system control and data processing unit automatically processes and analyzes data in the background, and the time to complete data processing is no more than 10 seconds. Users can view the processing and analysis results in the system operation unit.

[0175] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "an implementation", "specific implementation", "other implementations", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment, implementation or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described above may also be combined in a suitable manner in any one or more embodiments, implementations or examples. The technical solutions recorded in the present invention also include technical solutions formed by any one or more of the specific features, structures, materials or characteristics described above in a separate or combined manner.

[0176] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limiting the present invention. Ordinary technicians in the field can change, modify, replace, modify, delete some features, add features or re-combine features to form a technical solution in the above embodiments without departing from the principles and purpose of the present invention. Any simple modifications, equivalent changes and modifications made to the above embodiments based on the innovative principles of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A biomagnetic quantum detection system, characterized in that: include: An atomic magnetic sensor group for measuring biomagnetic field, composed of a plurality of atomic magnetic sensors, wherein the atomic magnetic sensor includes a sensor probe and a sensor controller; A magnetic shielding device (5) for shielding external magnetic fields and electromagnetic noise; A supporting and positioning mechanical device comprises a base (1), an examination bed assembly (2) for fixing a human body to be examined, and a probe bracket (4) for fixing a sensor probe; System control and data processing unit; and a system operating unit; Wherein, the sensor probe comprises: At least three first magnetic sensor probes (41) for collecting background noise and background magnetic field gradient information, and a plurality of second magnetic sensor probes (42) for receiving biological magnetic fields; the first magnetic sensor probes (41) and the second magnetic sensor probes (42) are both fixed on a probe bracket (4), and the second magnetic sensor probes (42) are located below the first magnetic sensor probes (41); The probe bracket (4) is arranged in the magnetic shielding device (5), and the sensor probe installed on the probe bracket (4) is connected to a sensor controller installed outside the magnetic shielding device (5) via a sensor cable (6); The probe bracket (4) is provided with three first magnetic sensor probes (41), namely probe A, probe B and probe C. Probe A and probe B are arranged up and down along the Z direction, and probe A and probe C are arranged front to back along the Y direction. A plurality of second magnetic sensor probes (42) are located below the first magnetic sensor probes (41) and are arranged in a row front to back along the Y direction. The three first magnetic sensor probes (41) and the plurality of second magnetic sensor probes (42) are located in the same YZ plane.

2. A biomagnetic quantum detection system according to claim 1, characterized in that: Four first magnetic sensor probes (41) are arranged on the probe bracket (4), namely probe A, probe B, probe C and probe D. Probe A and probe B are arranged up and down along the Z direction, probe A and probe C are arranged front and back along the Y direction, and probe A and probe D are arranged left and right along the X direction. At least four second magnetic sensor probes (42) are distributed in an array manner in the same detection plane.

3. A biomagnetic quantum detection system according to claim 1, characterized in that: The magnetic shielding device (5) is made of a high magnetic permeability material and has an internal space capable of accommodating a probe bracket and a human body to be measured. The magnetic shielding device (5) is a cylindrical magnetic shielding cylinder with one end closed and the other end open.

4. A biomagnetic quantum detection system according to claim 1, characterized in that: The supporting and positioning mechanical device comprises a base (1), an inspection bed assembly (2) and a probe bracket (4); the inspection bed assembly (2) is mounted on the base and can move linearly on the base (1) along the X direction; the probe bracket (4) is mounted on the inspection bed assembly (2) and can move linearly on the inspection bed assembly (2) along the X direction; a part of the base (1) is fixed inside the magnetic shielding device (5), and another part of the base (1) is fixed outside the magnetic shielding device (5).

5. A biomagnetic quantum detection system according to claim 1, characterized in that: The examination bed assembly (2) comprises an upper bed board and a lower bed board, wherein the upper bed board can move linearly along the X direction on the lower bed board; the upper bed board and the lower bed board are fixed in relative position with each other by a positioning device; the probe bracket (4) is mounted on the lower bed board of the examination bed assembly (2), and the probe bracket (4) and the examination bed assembly (2) are fixed in relative position with each other by a second locking device.

6. A biomagnetic quantum detection system according to claim 1, characterized in that: The probe bracket (4) is provided with a laser emitting device, which can emit a visible laser beam downward in the Z direction for indicating the measurement position; the visible laser beam indicates the measurement area, and assists in adjusting the position between the sensor probe and the measured body in the X direction and the Y direction; the shape of the laser beam is point-shaped or line-shaped in the XY plane; the number of beams is 1 to 4; and the laser color is red or green.

7. A biomagnetic quantum detection method, characterized in that: A biomagnetic quantum detection system as claimed in any one of claims 1 to 6 is used to implement biomagnetic field measurement.

8. A probe holder for a biomagnetic quantum detection system, characterized in that: The invention comprises at least three first magnetic sensor probes (41) for collecting background noise and background magnetic field gradient information, and a plurality of second magnetic sensor probes (42) for receiving biological magnetic fields; the first magnetic sensor probe (41) and the second magnetic sensor probe (42) are both fixed on a probe bracket (4), and the second magnetic sensor probe (42) is located below the first magnetic sensor probe (41); the probe bracket (4) is arranged in a magnetic shielding device (5), and the sensor probe installed on the probe bracket (4) is connected to a sensor controller installed outside the magnetic shielding device (5) through a sensor cable (6); three first magnetic sensor probes (41) are arranged on the probe bracket (4), namely probe A, probe B and probe C, respectively; probe A and probe B are arranged up and down along the Z direction, and probe A and probe C are arranged front and back along the Y direction; a plurality of second magnetic sensor probes (42) are located below the first magnetic sensor probe (41) and are arranged in a row front and back along the Y direction; the three first magnetic sensor probes (41) and the plurality of second magnetic sensor probes (42) are located in the same YZ plane.

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