A droplet transmission device

By designing a droplet transmission device, the vertical transmission of droplets is achieved by using the interval-set microfluidic module and the drive control module, the problem of cross-contamination of droplets in the prior art is solved, and the diversity of the transmission path and detection efficiency are improved.

CN113244971BActive Publication Date: 2025-03-18ZHONGSHAN POLYTECHNIC
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Patent Information

Application Number
CN202110575128.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-05-26
Publication Date
2025-03-18
Estimated Expiration
2041-05-26

AI Technical Summary

Technical Problem

In the existing planar digital microfluidic technology, droplets are prone to pass through the same path repeatedly when they move against the chip surface, resulting in cross-contamination.

Method used

A droplet transmission device is designed, including at least two microfluidic modules and a drive control module arranged at intervals. The vertical transmission of the droplets is achieved by the electrode arrays on two adjacent microfluidic modules facing each other and driven by the pulse signal to move the droplets from one microfluidic module to the other under the excitation of the pulse signal.

Benefits of technology

Through the vertical transmission of droplets, cross-contamination caused by droplets moving on a single surface is avoided, and a more diverse transmission path is provided, which improves the application efficiency of detection technology.

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Abstract

The present invention discloses a droplet transmission device, which includes at least two spaced-apart microfluidic modules and a drive control module. Each microfluidic module includes a substrate and an electrode array disposed on the substrate, the electrode arrays on two adjacent microfluidic modules face each other, the drive control module is connected to the electrode array to send a pulse signal to the electrode array, and the electrode array can drive the droplet to move from one microfluidic module to another microfluidic module under the stimulation of the pulse signal, thereby realizing the droplet detaching from the microfluidic surface for transmission, and reducing the probability of cross contamination.
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Description

Technical Field

[0001] The present invention relates to the field of microfluidic technology, and in particular to a droplet transmission device. Background Art

[0002] In the past 20 years, with the introduction of the concept of lab-on-chip (LOC), microfluidics has played a huge role in promoting the development of analytical science. Among them, digital microfluidics (DMF), represented by dielectric wetting, overcomes the limitations of components such as pipes, micropumps, microvalves and micromixers, and can directly manipulate and react tiny droplets using programming control, greatly promoting the development and application of detection technology.

[0003] The digital microfluidic module driven by dielectric wetting generally includes an electrode array, which applies voltage excitation to the droplets above the electrode array in sequence through program control, thereby driving the droplets to move along a predetermined path on the chip surface, and can achieve the generation, transmission, mixing and segmentation of droplets on a single plane. However, since the droplets will repeatedly pass through the same path when moving along the chip surface, the existing planar digital microfluidic technology inevitably produces the problem of cross-contamination. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a droplet transmission device that can realize the transmission of droplets away from the microfluidic surface, thereby reducing the probability of cross contamination.

[0005] A droplet transport device according to an embodiment of the first aspect of the present invention includes:

[0006] At least two spaced-apart microfluidic modules, each of which comprises a substrate and an electrode array disposed on the substrate, and the electrode arrays on two adjacent microfluidic modules face each other, and the electrode arrays can drive droplets to move from one microfluidic module to another microfluidic module under the stimulation of a pulse signal;

[0007] A driving control module is connected to the electrode array to send a pulse signal to the electrode array.

[0008] A droplet transmission device according to an embodiment of the present invention has at least the following beneficial effects:

[0009] According to an embodiment of the present invention, the droplet transmission device includes at least two spaced-apart microfluidic modules and a drive control module, each microfluidic module includes a substrate and an electrode array disposed on the substrate, and the electrode arrays on two adjacent microfluidic modules face each other, and the electrode arrays are connected to the drive control module. The drive control module can send a pulse signal to the electrode array of any microfluidic module, and the electrode array can generate an electric field under the excitation of the pulse signal, and then the droplets on the microfluidic module are rapidly deformed under the action of the electric field, and quickly retracted when the pulse signal ends, and the surface energy obtained when the droplets are deformed is converted into kinetic energy and causes the droplets to bounce to a certain height, so the droplets can detach from the microfluidic module and move to another spaced-apart microfluidic module, realizing the vertical transmission of droplets between different microfluidic modules, so that the droplets will not repeatedly pass through the same path due to moving along a single surface, reducing the probability of cross contamination.

[0010] According to some embodiments of the present invention, the microfluidic module further includes a dielectric layer, and the dielectric layer is disposed on the electrode array.

[0011] According to some embodiments of the present invention, the dielectric layer includes one or more of parylene, circuit board ink, photoresist and metal oxide.

[0012] According to some embodiments of the present invention, the microfluidic module further comprises a hydrophobic layer, wherein the hydrophobic layer is disposed on the dielectric layer.

[0013] According to some embodiments of the present invention, the hydrophobic layer includes one or more of paraffin, polytetrafluoroethylene, fluororesin, octafluorocyclobutane and a super hydrophobic layer.

[0014] According to some embodiments of the present invention, the microfluidic module also includes a capacitance detection module, which is connected to the electrode array to detect capacitance changes, and the drive control module is connected to the capacitance detection module to send a pulse signal to the electrode array according to the capacitance changes.

[0015] According to some embodiments of the present invention, the electrode array includes driving electrodes and reference electrodes, and the driving electrodes and the reference electrodes are cross-arranged on the substrate; the driving control module is connected to the driving electrodes to send a pulse signal to the driving electrodes, so that a potential difference is generated between the driving electrodes and the reference electrodes.

[0016] According to some embodiments of the present invention, the driving electrode is made of one or more of copper foil, chromium, indium tin oxide and conductive polymer, and the reference electrode is made of transparent conductive material.

[0017] According to some embodiments of the present invention, the drive control module includes a pressure supply unit and a control unit, the pressure supply unit is connected to the drive electrode, the pressure supply unit can generate a pulse signal, and the control unit is connected to the pressure supply unit to control the operation of the pressure supply unit.

[0018] According to some embodiments of the present invention, there are multiple driving electrodes, and the driving control module also includes an electrode selection unit, which is respectively connected to the pressure supply unit and each of the driving electrodes to control the on and off between the pressure supply unit and each of the driving electrodes, and the control unit is connected to the electrode selection unit to control the operation of the electrode selection unit.

[0019] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0021] Figure 1 This is a principle structural block diagram of a droplet transmission device in an embodiment of the present invention;

[0022] Figure 2 Schematic diagram of vertical transfer of droplets between adjacent microfluidic modules in an embodiment of the present invention;

[0023] Figure 3 This is a schematic diagram of the application of the microfluidic module driving droplet bouncing in an embodiment of the present invention;

[0024] Figure 4 This is a schematic structural diagram of a droplet transmission device in an embodiment of the present invention;

[0025] Figure 5 A schematic diagram of the structure and circuit connection of a microfluidic module in an embodiment of the present invention;

[0026] Figure 6 This is an application schematic diagram of a change in capacitance generated when a droplet contacts a microfluidic module in an embodiment of the present invention;

[0027] Figure 7 Schematic diagram of the relationship between droplet bounce height and pulse signal length in an embodiment of the present invention.

[0028] Reference numerals:

[0029] Microfluidic module 100 , substrate 110 , electrode array 120 , drive electrode 121 , reference electrode 122 , electrode spacing 123 , dielectric layer 130 , hydrophobic layer 140 , drive control module 200 , pressure supply unit 210 , control unit 220 and electrode selection unit 230 . DETAILED DESCRIPTION

[0030] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0031] In the description of the present invention, it should be understood that descriptions involving orientation, such as the orientations or positional relationships indicated by terms such as “upper”, “lower”, “front”, “back”, “left”, “right”, “vertical”, “horizontal”, “top”, “bottom”, “inside” and “outside” are based on the orientations or positional relationships shown in the accompanying drawings and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0032] In the description of the present invention, "several" means one or more, "more" means more than two, "greater than", "less than", "exceed" etc. are understood as not including the number itself, and "above", "below", "within" etc. are understood as including the number itself. If there is a description of "first" or "second", it is only used for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0033] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0034] like Figure 1-7As shown, a droplet transport device according to an embodiment of the present invention includes at least two spaced-apart microfluidic modules 100 and a drive control module 200. Each microfluidic module 100 includes a substrate 110 and an electrode array 120 disposed on the substrate 110, the electrode arrays 120 on two adjacent microfluidic modules 100 face each other, the drive control module 200 is connected to the electrode array 120 to send a pulse signal to the electrode array 120, and the electrode array 120 can drive the droplet to move from one microfluidic module 100 to another microfluidic module 100 under the stimulation of the pulse signal.

[0035] The electrode array 120 may include a plurality of electrodes arranged in an array on the substrate 110, and the electrode array 120 may be a printed electrode array 120, which is not limited thereto. Figure 2 As shown, the electrode array 120 of the upper microfluidic module 100 can be arranged on the lower surface of the upper substrate 110, and the electrode array 120 of the lower microfluidic module 100 can be arranged on the upper surface of the lower substrate 110. Therefore, the electrode arrays 120 of the two microfluidic modules 100 are relatively oriented, so that droplets can maintain reciprocating motion between the two microfluidic modules 100 under the action of the relatively oriented electrode arrays 120, thereby realizing the controllability of the vertical transmission of droplets between the two microfluidic modules 100.

[0036] In addition, the distance between two adjacent microfluidic modules 100 can be adjusted according to actual needs, and then the two adjacent microfluidic modules 100 can be bonded together using a viscous medium (such as glue). Figure 3 As shown, two adjacent microfluidic modules 100 are parallel to each other and spaced apart, so that a droplet motion space is formed between the two microfluidic modules 100. Specifically, a filling medium for filling the droplet motion space may be encapsulated between the two microfluidic modules 100, and the filling medium may be air or a liquid medium such as silicone oil, without specific limitation.

[0037] like Figure 3As shown, when the electrode array 120 does not receive the pulse signal excitation, the droplet is located on the electrode array 120, the contact area between the droplet and the electrode array 120 is small, and the surface energy is low. When the electrode array 120 receives the pulse signal excitation, the electrowetting drives the droplet to expand and deform, so that the center of mass of the droplet decreases and the surface area increases. When the pulse signal to the electrode array 120 ends, the droplet shrinks and deforms and the center of mass rises. The surface energy is converted into kinetic energy to drive the droplet to bounce to a certain height, so the droplet can be separated from the microfluidic module 100. Furthermore, when the bounce height of the droplet reaches the spacing between two adjacent microfluidic modules 100, the droplet can move from one microfluidic module 100 to another microfluidic module 100. It can be seen that the droplet transmission device in the embodiment of the present invention can realize the vertical transmission of droplets between different microfluidic modules 100, so the droplet will not repeatedly pass through the same path due to the movement against a single surface, and the probability of cross contamination can be reduced without introducing a transmission pipeline.

[0038] In addition, the drive control module 200 can also send pulse signals to different electrodes in the drive array in sequence, so that the droplets move along the surface path of the microfluidic module 100 under the driving action of different electrodes. Figure 4 Take this as an example to illustrate: Figure 4 As shown, the drive control module 200 first sends a pulse signal of a certain length to an electrode on the lower electrode array 120, and the droplets on the electrode will bounce upward to the upper electrode array 120 when the pulse signal ends. After that, the drive control module 200 sends pulse signals to the three electrodes arranged from left to right on the upper electrode array 120 in sequence, and the droplets can move along the corresponding right path under the action of the electric field of these three electrodes. Finally, when the pulse signals input to the upper electrode array 120 are all ended, the droplets can bounce to the lower electrode array 120 through deformation.

[0039] It can be seen that the droplet transport device simultaneously realizes the vertical transport of droplets between different microfluidic modules 100, and the two-dimensional plane transport of droplets on the same microfluidic module 100, thus providing a more diverse three-dimensional transport path and reducing the repeatability of the droplet transport path. Moreover, in applications involving heat transfer and temperature control, the microfluidic module 100 with three-dimensional transport function can also achieve more efficient heat exchange, thereby shortening the reaction time and test time.

[0040] In some embodiments of the present invention, Figure 5As shown, the microfluidic module 100 may further include a dielectric layer 130, which is disposed on the electrode array 120. Optionally, the dielectric layer 130 may include one or more of parylene, circuit board ink, photoresist, and metal oxide. Specifically, when a droplet contacts the surface of the microfluidic module 100, the bottom surface of the droplet, the dielectric layer 130, and the electrode array 120 may constitute a capacitive sensor, and as the overlapping area of ​​the bottom surface of the droplet and the electrode array 120 changes, the capacitance changes, thereby achieving the effect of variable area capacitive sensing.

[0041] like Figure 6 As shown, when the droplet does not contact the surface of the microfluidic module 100, the bottom surface of the droplet does not overlap with the electrode array 120, and the capacitance is zero. When the droplet contacts the surface of the microfluidic module 100, the overlapping area of ​​the bottom surface of the droplet and the electrode array 120 ( Figure 6 As the droplet (black part in the middle) increases, the capacitance also increases, and the capacitance reaches its maximum value when the droplet reaches the maximum expansion radius.

[0042] Furthermore, in some embodiments of the present invention, the microfluidic module 100 may also include a capacitance detection module, which is connected to the electrode array 120 to detect capacitance changes, and the drive control module 200 is connected to the capacitance detection module to send a pulse signal to the electrode array 120 according to the capacitance changes. In other words, by detecting the capacitance changes on the electrode array 120, the contact state between the droplet and the microfluidic module 100 can be accurately identified, and the pulse signal excitation to the electrode array 120 can be triggered in time, thereby driving the droplet to detach from the microfluidic module 100, or adsorbing the droplet on the surface of the microfluidic module 100 for subsequent control operations.

[0043] In one implementation, the capacitance detection module may include a resistor and a pulse counter, and the electrode array 120, the resistor and the pulse counter are connected in series. When the droplet contacts the surface of the microfluidic module 100, the electrode array 120, the resistor and the pulse counter connected in series constitute a resistor-capacitance circuit (RC circuit), which can determine the basic oscillation frequency. However, the capacitance change of the RC circuit can cause the oscillation frequency to change, and the oscillation frequency of the RC circuit decreases with the increase of capacitance. Based on this, the pulse counter is used to measure the frequency difference when the droplet is not in contact with and contacts the surface of the microfluidic module 100, and the corresponding capacitance value when the droplet contacts the surface of the microfluidic module 100 can be determined. In other implementations, the capacitance detection module can also use a capacitance measurement circuit based on the capacitor discharge amount or the discharge time ratio, without specific limitation.

[0044] In some embodiments of the present invention, Figure 5As shown, the microfluidic module 100 further includes a hydrophobic layer 140, and the hydrophobic layer 140 is disposed on the dielectric layer 130. Optionally, the hydrophobic layer 140 includes one or more of paraffin, polytetrafluoroethylene, fluororesin, octafluorocyclobutane and a super hydrophobic layer 140. Also optionally, the hydrophobic layer 140 may be related to the filling medium in contact with the hydrophobic layer 140. For example, if the filling medium is a liquid medium, the hydrophobic layer 140 may include one or more of paraffin, polytetrafluoroethylene, fluororesin, and octafluorocyclobutane; if the filling medium is air, the hydrophobic layer 140 may be a super hydrophobic layer 140, so that droplets in the air can be separated from the surface of the microfluidic module 100.

[0045] Specifically, the super-hydrophobic layer 140 can be obtained by increasing the physical roughness and surface hydrophobic modification of the hydrophobic coating, the size of the physical roughness can be 0.5 microns to 10 microns, and the thickness of the hydrophobic coating can be 100 nanometers to 500 nanometers. In addition, since the droplets are easy to slide on the surface of the super-hydrophobic layer 140, the minimum voltage value of the pulse signal input to the electrode array 120 must exceed the preset voltage value (slightly greater than 0V), thereby ensuring that the electric field generated by the electrode array 120 can play a role in adsorbing the droplets.

[0046] In some embodiments of the present invention, Figure 5 As shown, the electrode array 120 includes a driving electrode 121 and a reference electrode 122, and the driving electrode 121 and the reference electrode 122 are arranged crosswise on the substrate 110. The number of the driving electrode 121 and the reference electrode 122 can be one or more, and there is an electrode spacing 123 between two adjacent driving electrodes and reference electrodes 122, and there is no specific numerical limit on the number of electrodes and the spacing. The driving control module 200 is connected to the driving electrode 121 to send a pulse signal to the driving electrode 121, so that a potential difference is generated between the driving electrode 121 and the reference electrode 122. Among them, the reference electrode 122 can be grounded, thereby adopting a coplanar reference electrode 122 composite design, and there is no need to set up a ground electrode panel separately. Optionally, the driving electrode 121 can be made of one or more of copper foil, chromium, indium tin oxide and conductive polymer, and the reference electrode 122 can be made of transparent conductive material.

[0047] like Figure 6 As shown, when the bottom surface of the droplet contacts the driving electrode 121 and the reference electrode 122 at the same time, the droplet, the driving electrode 121 and the reference electrode 122 form a series capacitor. Specifically, the calculation formula of the series capacitor can satisfy:

[0048]

[0049] Among them, A d is the overlapping area between the bottom surface of the droplet and the driving electrode 121, A ris the overlapping area between the bottom surface of the droplet and the reference electrode 122, A t is the total overlapping area between the bottom surface of the droplet and the electrode array 120, C0 is the overlapping area between the droplet and the single electrode A t Optional, when A d =A r =A t , C=0.25C0.

[0050] In some embodiments of the present invention, the drive control module 200 includes a pressure supply unit 210 and a control unit 220, the pressure supply unit 210 is connected to the drive electrode 121, the pressure supply unit 210 can generate a pulse signal, and the control unit 220 is connected to the pressure supply unit 210 to control the operation of the pressure supply unit 210. Among them, the control unit 220 can be composed of a microcontroller unit 220 (MCU) or a central processing unit (CPU) and its peripheral circuits, without specific limitation. Specifically, the control unit 220 is connected to the capacitance detection module, the control unit 220 obtains the capacitance sensing signal from the capacitance detection module, and generates a control instruction, and then sends the control instruction to the pressure supply unit 210, so that the pressure supply unit 210 generates an AC pulse signal according to the pulse length indicated by the control instruction.

[0051] Further, the droplet has a decaying sinusoidal oscillation under the stimulation of the AC pulse signal, and the AC pulse stimulation of the droplet may correspond to a specific deformation of the droplet, that is, to the surface energy that drives the droplet to be vertically transmitted. In some implementations, the length of the AC pulse signal is related to the droplet bounce height. Figure 7 As shown, the y-axis represents the droplet bounce height, and the positive direction of the y-axis represents an increase in the droplet bounce height; the x-axis represents the pulse signal length, and the positive direction of the x-axis represents an increase in the pulse signal length. Figure 7 In the figure, the original droplet is deformed to shape a by applying a pulse length corresponding to shape a to the original droplet, and the droplet can be transported to a specified height y1; the original droplet is deformed to shape b by applying a pulse length corresponding to shape b to the original droplet, and the droplet can be transported to a specified height y2. Similarly, shapes c, d, e, and f correspond to specified heights y3, y4, y5, and y6, respectively. It can be seen that the droplet bounce height can be controlled by controlling the length of the AC pulse signal.

[0052] It should be noted that the droplet bounce height can meet the following requirements:

[0053]

[0054] Where h is the droplet bounce height, E kis the kinetic energy obtained by the droplet at the end of the AC pulse signal, mg is the droplet gravity, h0 is the vertical height of the initial center of gravity of the droplet, ΔE 界面 is the interface energy, E 粘性耗散 is the energy loss caused by viscous dissipation, E 接触线 is the energy loss caused by contact line friction, E 吸附 is the energy loss caused by interface adsorption, ΔE 界面 、E 粘性耗散 、E 接触线 and E 吸附 All of them can be calculated by established methods and will not be described in detail.

[0055] Specifically, the control unit 220 can determine the droplet bounce height according to the distance between two adjacent microfluidic modules 100, and then calculate the AC pulse signal length based on the droplet bounce height to generate a control instruction, thereby achieving precise control of the droplet bounce height and ensuring that the droplet moves to another microfluidic module 100. The droplet bounce height can be greater than or equal to the distance between two adjacent microfluidic modules 100, and the droplet bounce height and the AC pulse signal length meet the following conditions:

[0056]

[0057] Among them, H is the droplet bounce height, h0 is the bounce height reached by the droplet under the DC voltage excitation of the same amplitude, β is the calculation coefficient, τ is the AC signal pulse length, τ0 is the initial pulse length that causes the droplet to bounce, and T0 is the natural oscillation period of the droplet.

[0058] Furthermore, in some embodiments of the present invention, there are multiple driving electrodes 121, and the driving control module 200 may also include an electrode selection unit 230, which is respectively connected to the pressure supply unit 210 and each driving electrode 121 to control the on-off between the pressure supply unit 210 and each driving electrode 121, and the control unit 220 is connected to the electrode selection unit 230 to control the operation of the electrode selection unit 230. Therefore, the control unit 220 can simultaneously control the pulse excitation state of multiple driving electrodes 121, and flexibly select and control the driving electrode 121 to send a pulse signal to at least one designated driving electrode 121. Optionally, the electrode selection unit 230 may include multiple controllable switches, and the multiple controllable switches correspond one-to-one to the multiple driving electrodes 121. Figure 3 As shown, the control unit 220 can control the controllable switch to switch between a first position and a second position. When the controllable switch is in the first position, the pressure supply unit 210 is connected to the driving electrode 121 corresponding to the controllable switch, and when the controllable switch is in the second position, the pressure supply unit 210 is not connected to the driving electrode 121 corresponding to the controllable unit.

[0059] In one implementation, the control unit 220 can first locate the driving electrode 121 that generates capacitance change on the electrode array 120 through the capacitance detection module, and then control the driving electrode 121 that generates capacitance change to be connected to the pressure supply unit 210 through the electrode selection unit 230, while the driving electrode 121 that does not generate capacitance change is disconnected from the pressure supply unit 210, so that the pressure supply unit 210 sends an AC pulse signal to the driving electrode 121 that generates capacitance change, so that the position of the electric field excitation matches the contact position of the droplet on the surface of the microfluidic module 100, thereby achieving precise droplet drive control.

[0060] In another implementation, the control unit 220 may also control other driving electrodes 121 not contacted by the droplet to be connected to the pressure supply unit 210 through the electrode selection unit 230, so that the droplet moves toward the direction of the other driving electrodes 121 under the electric field excitation of the other driving electrodes 121.

[0061] The microfluidic module 100 and the control unit 200 can be integrated into a chip to obtain a microfluidic chip and a control chip, and the microfluidic chip and the pressure supply unit, as well as the pressure supply unit and the control chip can be electrically connected through a chip pin array. Furthermore, at least two microfluidic modules 100 can also be integrated into a whole digital microfluidic chip, which is convenient for practical application.

[0062] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0063] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A droplet transmission device, characterized in that: include: At least two spaced-apart microfluidic modules, each of which comprises a substrate and an electrode array disposed on the substrate, and the electrode arrays on two adjacent microfluidic modules face each other, and the electrode arrays can drive droplets to move from one microfluidic module to another microfluidic module under the stimulation of a pulse signal; A driving control module connected to the electrode array to send a pulse signal to the electrode array; The electrode array includes driving electrodes and reference electrodes, and the driving electrodes and the reference electrodes are cross-arranged on the substrate; The driving control module is connected to the driving electrode to send a pulse signal to the driving electrode, so that a potential difference is generated between the driving electrode and the reference electrode; the driving electrode is made of one or more of copper foil, chromium, indium tin oxide and conductive polymer, and the reference electrode is made of transparent conductive material; The driving control module includes a pressure supply unit and a control unit, the pressure supply unit is connected to the driving electrode, the pressure supply unit can generate a pulse signal, and the control unit is connected to the pressure supply unit to control the operation of the pressure supply unit; there are multiple driving electrodes, and the driving control module also includes an electrode selection unit, the electrode selection unit is respectively connected to the pressure supply unit and each of the driving electrodes to control the connection and disconnection between the pressure supply unit and each of the driving electrodes, and the control unit is connected to the electrode selection unit to control the operation of the electrode selection unit.

2. The droplet transport device according to claim 1, characterized in that: The microfluidic module further includes a dielectric layer, and the dielectric layer is disposed on the electrode array.

3. The droplet transport device according to claim 2, characterized in that: The dielectric layer includes one or more of parylene, circuit board ink, photoresist and metal oxide.

4. The droplet transport device according to claim 2, characterized in that: The microfluidic module further includes a hydrophobic layer, and the hydrophobic layer is disposed on the dielectric layer.

5. The droplet transport device according to claim 4, characterized in that: The hydrophobic layer includes one or more of paraffin, polytetrafluoroethylene, fluororesin, octafluorocyclobutane and a super hydrophobic layer.

6. The droplet transport device according to claim 2, characterized in that: The microfluidic module further comprises a capacitance detection module, which is connected to the electrode array to detect capacitance changes, and the drive control module is connected to the capacitance detection module to send a pulse signal to the electrode array according to the capacitance changes.

Citation Information

Patent Citations

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    CN216172410U