Applicator for water-soluble tablet preparations

Abstract

A more stable means of supplying moisture is provided, which comes from an applicator with a nozzle attached, and supplies moisture from the back side of a water-soluble sheet preparation. A nozzle for holding and dissolving a water-soluble sheet preparation, comprising a nozzle and an annular foam body, wherein the nozzle has at least one hole at the front end portion having a plane that can hold the size of the water-soluble sheet preparation, the plane other than the hole is smooth, and the annular foam body is arranged around the periphery of the front end portion of the nozzle; A nozzle for holding and dissolving a water-soluble sheet preparation, comprising a nozzle and an annular foam body, wherein the nozzle has at least one hole at the front end portion having a plane that can hold the size of the water-soluble sheet preparation, the plane other than the hole has a concave-convex portion, and the annular foam body is arranged around the periphery of the front end portion of the nozzle; and an applicator for a water-soluble sheet preparation, comprising a liquid container and the above-mentioned nozzle for holding and dissolving a water-soluble sheet preparation.

Description

Technical Field

[0001] The present invention relates to an applicator nozzle for applying a water-soluble sheet preparation to the skin and an applicator equipped with the nozzle. Background Art

[0002] As the method for drug administration to the human body, oral administration and transdermal administration are often utilized. Injection is a representative transdermal administration method, but it is cumbersome and accompanied by pain. During transdermal administration, the stratum corneum of the skin plays a role as a barrier for drug penetration. If only the drug is applied to the skin surface, the permeability may not be sufficient. In contrast, by using tiny needles, i.e., microneedles perforate the stratum corneum, thereby compared with the coating method, the drug penetration efficiency can be significantly improved. A plurality of such microneedles are integrated on a substrate to form a microneedle array. In addition, additional adhesive sheets for making the microneedle array attached to the skin, protective release sheets for protecting the adhesive sheets and as support when the microneedle array is attached to the skin, etc., make it become a product easy to use and be called a microneedle patch.

[0003] When administering a microneedle array to the skin, it is not easy to insert the microneedles into the skin if the microneedle array is simply pressed with a finger. This is because the skin is generally a soft and elastic tissue, so even if the sharp tip of the microneedle is pressed against the skin, the skin absorbs the impact and deforms, thereby preventing the microneedle from penetrating into the skin.

[0004] In order to give the microneedle array to the skin with impact absorption capacity, it is appropriate to impact the microneedle array toward the skin. As a specific method thereof, microneedle drug delivery devices (microneedle applicators) using springs (patent documents 1-6, 8), air pressure (patent document 5), magnetic force (patent document 7), etc. have been proposed so far. In order to make it easy for women and children to use the spring, it is necessary to work hard in the spring compression method and the triggering method. In addition, the use of air pressure and magnetic force may not necessarily be said to be simple. There are practical problems in the previous microneedle array giving device, and the user needs a device that is simpler and can reliably achieve puncture.

[0005] The microneedle made of water-soluble material will be dissolved by the moisture in the skin after piercing, but this requires considerable time, especially in the case of cosmetics for the purpose, so the convenience of the person being administered will be significantly damaged. If a microneedle array is made with a water-soluble material, moisture is supplied from its back side after piercing the skin, and the microneedle dissolves rapidly (patent documentation 9). In addition, the inventors have reported: the development of a cosmetic hyaluronic acid gel sheet using hyaluronic acid as a water-soluble polymer as a raw material, a small amount of water is added after being applied to the skin for massage, thus promoting the penetration of hyaluronic acid and matching components to the skin (patent documentation 10).

[0006] The present inventors have developed an applicator that can reliably administer a water-soluble sheet preparation to the skin of various sites and can supply moisture from the back side of the water-soluble sheet preparation (Patent Document 11).

[0007] Prior art literature

[0008] Patent Literature

[0009] Patent Document 1: Japanese Patent Publication No. 2004-510530 (Patent No. 4198985)

[0010] Patent Document 2: Japanese Patent Publication No. 2004-510534 (Patent No. 4104975)

[0011] Patent Document 3: Japanese Patent Publication No. 2004-510535 (Patent No. 4659332)

[0012] Patent Document 4: Japanese Patent Application No. 2005-533625

[0013] Patent Document 5: Japanese Patent Application No. 2006-500973

[0014] Patent Document 6: Japanese Patent Publication No. 2007-509706 (Patent No. 4682144)

[0015] Patent Document 7: Japanese Patent Application Publication No. 2011-078711

[0016] Patent Document 8: Japanese Patent Application Publication No. 2014-42788

[0017] Patent Document 9: Japanese Patent Application Publication No. 2011-194189 (Japanese Patent Application No. 5408592)

[0018] Patent Document 10: Japanese Patent Application Publication No. 2014-024828 (Japanese Patent Application No. 5840107)

[0019] Patent Document 11: Japanese Patent Application Publication No. 2018-164688 Summary of the invention

[0020] Problems to be solved by the invention

[0021] In order to improve the adhesion to the skin, microneedle arrays and cosmetic gel sheets made of water-soluble polymers are flexible sheet preparations with a thickness of about hundreds of μm. When applied to the skin, the water-soluble sheet preparation absorbs moisture from the fingertips and adheres to the fingers more than the target skin, or when applied to the scalp, the hair hinders the adhesion and peels off before being absorbed from the scalp. Therefore, the inventors have developed a nozzle that allows the water-soluble sheet preparation to be easily attached and detached, and have successfully developed an applicator that can instantly apply and dissolve the water-soluble sheet preparation to the skin by installing the nozzle in various liquid containers (Patent Document 11).

[0022] However, when water is supplied from the back of a water-soluble sheet preparation using an applicator equipped with the above-mentioned nozzle, if the degree of contact between the nozzle and the skin is not properly adjusted, water may not be supplied properly. More specifically, if the nozzle is pressed against the skin too much, water may not be supplied sufficiently to the skin, and if the angle of the nozzle toward the skin is not appropriate, water may flow along the skin.

[0023] An object of the present invention is to provide a more stable means for supplying moisture from an applicator with a nozzle attached, which supplies moisture from the back side of a water-soluble sheet preparation.

[0024] Here, the water-soluble sheet preparation in the present invention includes not only microneedle arrays, but also sheet preparations for the purpose of being quickly dissolved in water and absorbed by the skin after being applied to the skin, such as water-soluble gel sheets for cosmetics. The water-soluble sheet preparation is prepared with a water-soluble polymer as a base, and the thickness is about 1 mm or less. As water-soluble polymers, hyaluronic acid (or its sodium salt) and its derivatives, collagen, hydroxypropyl cellulose, chondroitin sulfate, dextran, proteoglycan, etc., and mixtures thereof, etc. can be cited. The back side of the water-soluble sheet preparation refers to the side opposite to the skin surface that is closely attached.

[0025] Means for solving problems

[0026] In order to solve the above-mentioned problems, the present inventors have conducted intensive research and successfully developed a nozzle that allows water-soluble sheet preparations to be easily attached and detached. The inventors found that the nozzle can provide a more stable supply of water to the skin by surrounding the outer periphery of the nozzle tip, which is the liquid outlet, with a foam body, and developed a device that can attach the nozzle to various liquid containers and properly and accurately apply and dissolve the water-soluble sheet preparation to the skin, thereby completing the present invention.

[0027] The present invention is as follows.

[0028] [1] A nozzle for holding and dissolving a water-soluble sheet preparation, comprising a nozzle and an annular foam body, wherein the nozzle has at least one hole at the front end portion of a plane having a size capable of holding the water-soluble sheet preparation, and the plane except for the hole is smooth, and the annular foam body is arranged around the periphery of the front end portion of the nozzle.

[0029] [2] A nozzle for holding and dissolving a water-soluble sheet preparation, comprising a nozzle and an annular foam body, wherein the nozzle has at least one hole at the front end portion of a plane having a size capable of holding the water-soluble sheet preparation, and the plane excluding the hole has a concave-convex portion, and the annular foam body is arranged around the periphery of the front end portion of the nozzle.

[0030] [3] The nozzle for retaining and dissolving a water-soluble sheet preparation according to [2], wherein the depth of the concavoconvex portion is 0.1 mm to 3.0 mm.

[0031] [4] The nozzle for retaining and dissolving a water-soluble sheet-form preparation according to [2] or [3], wherein the concavo-convex portion is formed with a groove extending from the hole toward the peripheral edge of the front end portion.

[0032] [5] The nozzle for retaining and dissolving a water-soluble sheet-form preparation according to any one of [2] to [4], wherein the peripheral edge of the front end portion is surrounded by a convex portion that is higher than the concavoconvex portion.

[0033] [6] A nozzle for maintaining and dissolving a water-soluble sheet preparation according to any one of [1] to [5], wherein when the front end of the nozzle is directed upward and the periphery of the front end is in a horizontal direction, the upper end of the foam is 0.1 mm to 10 mm higher than the periphery of the front end of the nozzle.

[0034] [7] A nozzle for holding and dissolving a water-soluble sheet preparation according to any one of [1] to [6], wherein the nozzle is made of a synthetic resin selected from the group consisting of polyethylene resin, polypropylene resin, soft polyolefin resin, polyurethane resin, polyvinyl chloride, soft polyvinyl chloride resin, and silicone resin.

[0035] [8] The nozzle for retaining and dissolving a water-soluble sheet preparation according to any one of [1] to [7], wherein the nozzle is made of a self-adhesive synthetic resin.

[0036] [9] A nozzle for holding and dissolving a water-soluble sheet preparation according to any one of [1] to [8], wherein the nozzle is made of a self-adhesive synthetic resin selected from soft polyolefin resins, polyurethane resins, soft polyvinyl chloride resins, and silicone resins.

[0037]

[10] The nozzle for holding and dissolving a water-soluble sheet preparation according to any one of [1] to [9], wherein the material of the foam is selected from polyurethane, polyolefin, phenolic resin, polyvinyl chloride, urea-formaldehyde resin, and a mixture thereof.

[0038]

[11] An applicator for a water-soluble sheet preparation, comprising a liquid container and a nozzle for holding and dissolving the water-soluble sheet preparation according to any one of [1] to

[10] .

[0039]

[12] The applicator according to

[11] , wherein the nozzle is attached to the opening of the liquid container.

[0040]

[13] The applicator according to

[11] or

[12] , wherein a water-soluble sheet preparation is held at the front end of the nozzle and applied to the skin, and liquid is supplied to the back of the preparation by pressing the liquid container.

[0041]

[14] The applicator according to

[11] , wherein the liquid container is equipped with a spray device, and the nozzle is mounted on the front end opening of the spray device.

[0042]

[15] The applicator according to

[14] , wherein a water-soluble sheet preparation is held at the front end of the nozzle and applied to the skin, and liquid is supplied to the back side of the preparation by the spray device.

[0043]

[16] The applicator according to

[11] , wherein the liquid container is equipped with a pump, and the nozzle is mounted on the front end opening of the pump.

[0044]

[17] The applicator according to

[16] , wherein a water-soluble sheet preparation is held at the front end of the nozzle and applied to the skin, and the pump is pressed to discharge the liquid to the back of the preparation.

[0045] Effects of the Invention

[0046] The nozzle for maintaining and dissolving the water-soluble sheet preparation of the present invention (hereinafter, abbreviated as "the nozzle with a foam ring edge of the present invention") can quickly dissolve the preparation by pressing the front end of the nozzle against the water-soluble sheet preparation attached to the skin and supplying water from the hole of the nozzle. The present invention is characterized in that there is an annular edge made of a foam around the nozzle. The ring edge is made of a continuous bubble foam, and when water is supplied from the nozzle hole, the air between the nozzle and the skin can be discharged smoothly to the outside. Therefore, compared with the case without the ring edge, the water supplied to the skin by the nozzle with a foam ring edge of the present invention can reach the back of the microneedle patch more easily and smoothly. The front end of the nozzle preferably has a concave-convex portion, but in the nozzle with a ring edge of the present invention, the concave-convex portion is not necessarily required.

[0047] The applicator of the present invention comprises a nozzle with a foam ring edge of the present invention and a liquid container. As long as the opening of the liquid container and the nozzle can be fitted, any liquid container can be used. In the case of applying a water-soluble microneedle array using the applicator of the present invention, the microneedles are reliably pierced into the skin by pressing the front end of the nozzle against the microneedle array and leaving it for an appropriate time. In addition, water is evenly and comprehensively supplied from the liquid container to the back of the array by pressing the front end of the nozzle against the microneedle array, thereby rapidly dissolving the microneedle array. At this time, with the help of the foam ring edge, water is accurately and evenly supplied to the back of the microneedle array, and there is no inconvenience such as water flowing down the skin. In the case of using the applicator of the present invention to apply a water-soluble gel sheet for cosmetics, the gel sheet is rapidly dissolved and diffused to the skin surface by pressing the front end of the nozzle against the gel sheet and supplying water in the liquid container from the back, promoting the skin's moisturizing and the absorption of active ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] [ Figure 1 ] Figure 1 1 and 2 are a cross-sectional view and a bottom view of the nozzle of Example 1.

[0049] [ Figure 2 ] Figure 2 This is a diagram of an applicator in which the nozzle of Example 1 is mounted on a polyethylene liquid container.

[0050] [ Figure 3 ] Figure 3 Examples of nozzles (A, B, C). The left side shows a bottom view, and the right side shows a cross-sectional view. For simplicity, the annular foam is omitted.

[0051] [ Figure 4 ] Figure 4 These are examples of applicators in which a nozzle is attached to a liquid container (A, B, C). DETAILED DESCRIPTION

[0052] The nozzle with a foam ring edge of the present invention comprises a nozzle (hereinafter sometimes abbreviated as "the nozzle in the present invention") and an annular foam (hereinafter sometimes abbreviated as "the foam in the present invention"), wherein the nozzle has at least one hole at the front end portion of a plane having a size capable of holding a water-soluble sheet preparation, and the plane except the hole is smooth or has concave-convex portions, and the annular foam is arranged around the periphery of the front end portion of the nozzle.

[0053] The nozzle of the present invention is a water supply member for the purpose of dissolving a water-soluble sheet preparation. The front end of the nozzle has a plane that can keep the size of the water-soluble sheet preparation. The nozzle of the present invention can change the shape of the plane of the front end according to the size of the water-soluble sheet preparation, and can also be a polygon such as a circle, an ellipse, a jade-shaped, a triangle, a quadrangle, a pentagon, a hexagon, etc. The main body of the nozzle of the present invention can also be a cylindrical, an elliptical cylindrical, or a multi-prism in accordance with the shape of the plane of the front end. In order to be able to fit with the opening of various liquid containers, a cylindrical shape is preferred.

[0054] Preferably, the peripheral edge of the tip of the nozzle in the present invention is surrounded by a convex portion higher than the above-mentioned smooth plane or the above-mentioned concavoconvex portion so that the supplied water does not overflow. The convex portion of the peripheral edge acts as a weir to prevent the water diffused on the above-mentioned smooth plane or the water diffused through the grooves formed by the above-mentioned concavoconvex portion from escaping to the outside of the water-soluble sheet preparation.

[0055] The front end of the nozzle in the present invention has at least one hole. In order to introduce water from the liquid container to the back of the water-soluble sheet preparation, the holes may be two or more, and the size of the holes is not particularly limited. The position of the hole may be the center of the plane of the front end or the peripheral part. The arrangement and spacing of the plurality of holes are also not particularly limited.

[0056] The plane of the front end of the nozzle in the present invention can be smooth. However, in order to further uniformly supply water to the front end of the nozzle, it is preferred that a concave-convex portion is formed on the plane in addition to the above-mentioned hole. The concave-convex portion can be in any shape such as spiral, dot, radial, etc. as long as the water-soluble sheet preparation can be installed and removed from the front end of the nozzle and a groove can be formed so that water can be supplied from the hole to the entire front end. Typically, the degree of concave-convex is preferably a depth of 0.1mm to 3.0mm, more preferably 0.1mm to 2.0mm. If the depth is less than 0.1mm, the water supplied through the hole lacks rapidity in supplying to the surface. In addition, if the depth is more than 3.0mm, a large amount of water supplied through the hole is required to cover the entire surface.

[0057] The area ratio of the convex part or plane part to the groove part or recessed part is preferably 20:1 or more. If the area ratio of the recessed part is too small, the groove part is small, and it is difficult to supply water to the entire bottom surface. In addition, if the area of ​​the groove part is too large, the plane of the nozzle plane part becomes small, and even if the water-soluble sheet is pressed against the skin by the nozzle, the closeness with the plane part is not sufficient, and it may not be fully attached to the nozzle. Therefore, the area ratio of the convex part or plane part to the groove part or recessed part is preferably 1:10 or less.

[0058] In order to smoothly supply an appropriate amount of water to the entire water-soluble sheet preparation, the nozzle of the present invention preferably has a groove extending from the hole to the periphery of the front end portion in the concave-convex portion. Here, the groove refers to a lowland formed by two adjacent convex portions and a concave portion surrounded by the two convex portions. The shape of the groove is not particularly limited. As a specific example, there can be cited: Figure 1 The front end of the nozzle shown has concentric elongated grooves in the concave-convex part 3 extending concentrically around the hole 2 in the center, and radial (fan-shaped) grooves 5 directly connected to the hole 2. The nozzle also has a convex part 4 formed on the periphery.

[0059] Another aspect of the nozzle of the present invention is shown in Figure 3 .exist Figure 3 In A, the plane of the front end portion of the nozzle is smooth, and neither concavo-convex portions nor grooves are formed. Figure 3 The C in the figure is formed with radial grooves 5 and concentric grooves. Figure 3 In B, the concavo-convex portion 3 is formed by a plurality of dots, and a dot-shaped groove 5 is formed from the hole 2 toward the periphery.

[0060] The material of the nozzle in the present invention is not particularly limited, and various materials such as metal, ceramic, and plastic can be used. If the ease of manufacture, convenience of use, etc. are taken into consideration, plastic is preferred, among which polyolefin resins such as polyethylene resin and polypropylene resin, polyvinyl chloride, polyurethane resin, and synthetic resins such as silicone resin are more preferred. If the fit with liquid containers of various materials and the good contact feel of the nozzle to the skin are taken into consideration, soft polymer substances are preferred. The scale of the hardness of the nozzle material, i.e., the Young's modulus, is preferably 500Pa~5MPa. The glass transition temperature of this soft polymer is below room temperature, and it is in a rubbery state at room temperature, and has self-adhesiveness and adhesion to the back of the microneedle patch. Here, room temperature refers to 20°C~25°C. Such a property is called self-adhesiveness. Even if the polymer itself is hard, it can also be a synthetic resin that is soft and self-adhesive as a resin composition containing a plasticizer. As specific materials, soft polyolefin resins, polyurethane resins, soft vinyl chloride resins, and silicone resins are preferred, and silicone resins are further preferred. The nozzle has the advantage of self-adhesiveness that the adhesion to the water-soluble sheet preparation is improved, the sheet preparation is adhered to the nozzle by weak contact, and the sheet preparation is pressed against the skin in this state, thereby having the advantage of being able to apply the sheet preparation to the skin.

[0061] The synthetic resin nozzle can be produced by a known method, for example, by injecting a raw material resin into a mold and molding it.

[0062] Regarding the nozzle with a foam ring edge of the present invention, an edge made of an annular foam is arranged around the periphery of the front end of the nozzle in the present invention. The annular foam is arranged so as to be higher than the above-mentioned smooth plane or the above-mentioned concavo-convex part, and then the convex part of the periphery, so that the supplied water flows evenly to the front end of the nozzle without overflowing. The annular foam of the periphery acts as a weir to prevent the water spread to the front end from escaping to the outside of the water-soluble sheet preparation.

[0063] As the foam in the present invention, all resin foams can be formed and used. The resin foam used is a continuous bubble type. The continuous bubble type is preferred because it has open bubbles that are connected and communicated. If the bubble diameter is too small, air is difficult to penetrate, and if the bubble diameter is too large, water is also easy to penetrate, so the bubble diameter is preferably 0.1 mm or more and 5 mm or less.

[0064] The foam body in the present invention is arranged around the periphery of the front end portion of the nozzle in the present invention. The shape of the foam body is an annular shape having a hollow in the center that matches the periphery of the front end portion of the nozzle. The outer periphery of the annular shape is typically circular, but it can also be elliptical or polygonal. The shape of the central hollow can be appropriately set according to the shape of the plane of the front end portion of the nozzle, and can be circular, elliptical, or jade-shaped; it can also be a polygon such as a triangle, quadrilateral, pentagon, hexagon, or octagon.

[0065] Regarding the relationship between the annular foam and the nozzle, the upper end of the foam needs to be higher than the peripheral edge of the front end of the nozzle. When the front end of the nozzle is directed upward and the peripheral edge of the front end is in a horizontal direction, the upper end of the foam is preferably 0.1 mm to 10 mm higher than the peripheral edge of the front end of the nozzle, and more preferably 0.3 mm to 5 mm higher.

[0066] The raw material of the foam in the present invention is not particularly limited, and examples thereof include synthetic resins, such as polyurethane, polyolefin (polyethylene, polypropylene, etc.), phenolic resin, polyvinyl chloride, urea resin, and mixtures thereof.

[0067] The size of the foam in the present invention can be set to any size according to the shape of the configured nozzle. In the case of a concentric donut-shaped foam with a circular hole in the center, the difference between the radii of the two circles, that is, the size of the portion surrounding the nozzle, is usually about 5 mm to 30 mm, preferably 7 mm to 20 mm. Foams of other shapes can also be set in the same way as the concentric donut-shaped foam.

[0068] The foam of the present invention may be produced by producing a foam block having interconnected cells by a known chemical foaming method or a physical foaming method, and then molding the produced foam block by slicing, slitting, punching, or the like.

[0069] The annular foam body produced as described above can be made into a nozzle with a foam body of the present invention by placing the front end of the nozzle in the present invention into the central hollow portion and fixing it at a predetermined position. When the front end of the nozzle is directed upward and the peripheral edge of the front end is in a horizontal direction, the fixing position of the annular foam body is preferably such that the upper end of the annular foam body is 0.1 mm to 10 mm higher than the peripheral edge of the front end of the nozzle, and more preferably 0.3 mm to 5 mm higher.

[0070] Examples of the fixing method include fixing with an adhesive or the like, fixing with a stopper provided at a position rearward of the tip of the nozzle by the thickness of the annular foam, and the like.

[0071] In the case of a fixing method using an adhesive or the like, the annular foam body is replaced together with the nozzle, and in the case of a fixing method using a stopper, only the annular foam body can be replaced. In the latter case, the annular foam body can be removed from the nozzle each time it is used, and the annular foam body can be cleaned and dried to maintain the cleanliness of the foam body. In addition, in the case where only the annular foam body is deteriorated, the foam body can be partially replaced.

[0072] The applicator of the present invention comprises a liquid container and a nozzle with a foam ring edge of the present invention. The above-mentioned liquid container and the nozzle with a foam ring edge can be a separate combination. In this case, the nozzle with a foam ring edge is installed in the opening of the liquid container when in use. The liquid container can be pre-filled with liquid, or the liquid can be injected immediately before use. In the present invention, the liquid is typically water, but as long as it can dissolve the water-soluble sheet preparation, it can also be a mixed liquid with a solvent other than water. In addition, it can also be an aqueous solution containing a medicinal ingredient or an active ingredient suitable for skin as needed.

[0073] The material of the liquid container is not particularly limited, and various materials such as metal, ceramic, and plastic can be used in consideration of the fit with the nozzle. If the ease of manufacture and the convenience of use are taken into consideration, plastic is preferred, and polyolefin resins such as polyethylene resin and polypropylene resin, and synthetic resins such as polyvinyl chloride, polyurethane resin, and silicone resin are more preferred.

[0074] The applicator of the present invention has a nozzle with a foam ring edge of the present invention. For example, Figure 4 The applicator shown in C in FIG. In this case, the water-soluble sheet preparation can be held at the front end of the nozzle and applied to the skin, and the liquid can be supplied to the back of the preparation by pressing the above-mentioned liquid container. The amount of liquid supplied can be appropriately set according to the size (area, thickness) of the water-soluble sheet preparation. The amount of liquid can be adjusted by the size of the nozzle hole, the pressure applied to the liquid container, the number of presses, etc.

[0075] In the case where the liquid container is equipped with a spray device, the applicator of the present invention is provided with a nozzle at the front end opening of the spray device. Figure 4 In this case, the water-soluble sheet preparation can be held at the front end of the nozzle and applied to the skin, and the liquid can be supplied to the back of the preparation by the spray device. The amount of liquid supplied can be appropriately set according to the size (area, thickness) of the water-soluble sheet preparation. The amount of liquid can be adjusted by the size of the nozzle hole, the discharge capacity of the spray device, the number of shots, etc.

[0076] When the liquid container is equipped with a pump, the applicator of the present invention is provided with a nozzle at the front end opening of the pump. Figure 4 The applicator shown in A in FIG. In this case, the water-soluble sheet preparation can be held at the front end of the nozzle and applied to the skin, and the pump can be pressed to discharge the liquid to the back of the preparation. The amount of liquid discharged can be appropriately set according to the size (area, thickness) of the water-soluble sheet preparation. The amount of liquid can be adjusted by the size of the nozzle hole, the discharge capacity of the pump, the number of discharges, etc.

[0077] In this way, the present invention uses various liquid containers, and by installing the nozzle with a foam ring edge of the present invention in a manner that can be fitted into the opening of the liquid container, it is possible to provide various types of applicators. Therefore, the nozzle and the liquid container can be freely combined according to the shape, application purpose, application frequency, application site, etc. of the water-soluble sheet preparation. In addition, the nozzle with a foam ring edge of the present invention can be mass-produced inexpensively, so it can be replaced and used for each subject and each application day. After use, the applicator can also remove the nozzle with a foam ring edge, seal the opening with a cover, etc., refrigerate and store the liquid remaining in the liquid container, and use it again within the service life. In addition, the applicator of the present invention can also be installed with a liquid container filled with one amount of liquid and a nozzle with a foam ring edge, and used as a disposable device that is used up once.

[0078] Hereinafter, the embodiments of the present invention will be described based on examples. However, the present invention is not limited to the contents of the examples.

[0079] Example

[0080] Example 1

[0081] Make as Figure 1 The nozzle is shown in FIG. It is made by injection molding using silicone resin (one-component RTV rubber, Shin-Etsu Chemical Co., Ltd.). The diameter of the plane of the nozzle tip 1 is 12 mm, the depth of the concentric concave and convex parts 3 is 0.5 mm, and the interval between the concave and convex parts is 1 mm. The cross section of the entire nozzle is shown in FIG. Figure 1The top view of the nozzle is shown in Figure 1 The hole 2 passes through the center of the nozzle body 10 and can be seen in the center of the front end. The liquid comes out of the hole 2, spreads to the groove 5, and then spreads to the entire plane through the concave-convex part 3. The polyurethane foam sheet (Daban Co., Ltd., special order product, foaming ratio 5 times, thickness 2.0 cm) is cut and punched into a circle with an outer shape of 3.0 cm, and then an annular foam with a hole with a central inner diameter of 1.5 cm is made. The annular foam is fixed around the front end of the nozzle and is set 1.0 mm higher than the plane of the front end of the nozzle.

[0082] The nozzle with the foam ring is mounted on a polyethylene container (see Figure 2 ), 0.1 g of Limuveil HV (aqueous solution containing 1.2% fucoidan, produced by Tanglewood Co., Ltd.) was dissolved in 200 g of water, and the extract containing fucoidan was filled into the applicator to prepare an applicator.

[0083] The microneedle patch is manufactured as follows. 5 g of hyaluronic acid (FCH-80, derived from culture, Kikkoman Biochemifa Co., Ltd.) and 5 g of Limuveil HV are added to 90 g of water to make a uniform solution. The aqueous solution is cast on a mold, dried at room temperature for 24 hours, and extracted from the mold to obtain a microneedle array sheet. The sheet is cut to obtain a microneedle array with a diameter of 1 cm. The fucoidan content of each microneedle is 25 μg. This microneedle patch and extract are preparations for the purpose of hair growth.

[0084] Before use, the back of the microneedle array was pressed with the nozzle of the applicator to keep it attached. The fucoidan extract was supplied from the back of the microneedle array by pressing the container on the forehead of the volunteer. This test was conducted on 10 volunteers. The forehead of the 10 volunteers was observed when the applicator was pressed, and no water flowed out from the nozzle surface.

[0085] Comparative Example 1

[0086] The same test as in Example 1 was conducted using the same nozzle as in Example 1 except that the nozzle had no ring edge. The fucoidan extract was supplied from the back of the microneedle array by pressing the container. This test was conducted on 10 volunteers. When the forehead was pressed on the applicator, water flowed out from the nozzle surface in 3 of the 10 volunteers.

[0087] Description of Reference Numerals

[0088] 1: The front end of the nozzle

[0089] 2: Hole

[0090] 3: Concave and convex part

[0091] 4: The convex part of the peripheral edge

[0092] 5: Slot

[0093] 6: Annular foam

[0094] 10: Nozzle body

[0095] 20: Liquid container

[0096] 21: Opening

[0097] 22: Pump

[0098] 23: Spray device

Claims

1. A nozzle for holding and dissolving a water-soluble sheet-like preparation, comprising a nozzle and an annular foam body, wherein the nozzle has a hole at a front end portion of a plane having a size capable of holding a water-soluble sheet-like preparation, the plane has a concave-convex portion extending concentrically with the hole at a center portion as a center, the concave-convex portion is formed with a groove extending from the hole to the peripheral edge of the front end portion, and the annular foam body is arranged around the peripheral edge of the front end portion of the nozzle, The depth of the concave-convex portion is 0.1 mm to 3.0 mm, The peripheral edge of the front end portion is surrounded by a convex portion that is higher than the concavo-convex portion.

2. The nozzle for retaining and dissolving a water-soluble sheet preparation according to claim 1, wherein: When the front end of the nozzle is directed upward and the peripheral edge of the front end is in a horizontal direction, the upper end of the foam body is 0.1 mm to 10 mm higher than the peripheral edge of the front end of the nozzle.

3. The nozzle for holding and dissolving a water-soluble sheet preparation according to claim 1 or 2, wherein: The nozzle is made of a synthetic resin selected from polyethylene resin, polypropylene resin, polyurethane resin and polyvinyl chloride.

4. The nozzle for holding and dissolving a water-soluble sheet preparation according to claim 1 or 2, wherein: The nozzle is made of a synthetic resin selected from soft polyolefin resin and silicone resin.

5. The nozzle for retaining and dissolving a water-soluble sheet preparation according to claim 1 or 2, wherein: The nozzle is made of soft polyvinyl chloride resin.

6. The nozzle for holding and dissolving a water-soluble sheet preparation according to claim 1 or 2, wherein: The nozzle is made of a synthetic resin having self-adhesiveness.

7. The nozzle for retaining and dissolving a water-soluble sheet preparation according to claim 1 or 2, wherein: The nozzle is made of a self-adhesive synthetic resin selected from soft polyolefin resins and polyurethane resins.

8. The nozzle for retaining and dissolving a water-soluble sheet preparation according to claim 1 or 2, wherein: The nozzle is made of a self-adhesive synthetic resin selected from soft polyvinyl chloride resin and organic silicon resin.

9. The nozzle for retaining and dissolving a water-soluble sheet preparation according to claim 1 or 2, wherein: The material of the foam is selected from polyurethane, polyolefin, phenolic resin, urea-formaldehyde resin and a mixture thereof.

10. The nozzle for retaining and dissolving a water-soluble sheet preparation according to claim 1 or 2, wherein: The material of the foam is selected from polyurethane, phenolic resin, polyvinyl chloride, urea-formaldehyde resin and a mixture thereof. 11 . An applicator for a water-soluble sheet preparation, comprising a liquid container and a nozzle for holding and dissolving the water-soluble sheet preparation according to claim 1 .

12. The applicator according to claim 11, wherein The nozzle is mounted on the opening of the liquid container.

13. An applicator according to claim 11 or 12, wherein The water-soluble sheet preparation is held at the front end of the nozzle and applied to the skin, and the liquid is supplied to the back of the preparation by pressing the liquid container.

14. The applicator of claim 11, wherein: The liquid container is equipped with a spray device, and the nozzle is mounted on the front end opening of the spray device.

15. An applicator according to claim 14, wherein A water-soluble sheet preparation is held at the front end of the nozzle and applied to the skin, and liquid is supplied to the back of the preparation by the spray of the spray device.

16. The applicator of claim 11, wherein: The liquid container is equipped with a pump, and the nozzle is mounted on the front end opening of the pump.

17. An applicator according to claim 16, wherein The water-soluble sheet preparation is held at the tip of the nozzle and applied to the skin, and the pump is pressed to discharge the liquid to the back of the preparation.

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